Read by QxMD icon Read

Appetite supressant

S Nymo, S R Coutinho, J Jørgensen, J F Rehfeld, H Truby, B Kulseng, C Martins
BACKGROUND/OBJECTIVE: Diet-induced weight loss (WL) leads to increased hunger and reduced fullness feelings, increased ghrelin and reduced satiety peptides concentration (glucagon-like peptide-1 (GLP-1), cholecystokinin (CCK) and peptide YY (PYY)). Ketogenic diets seem to minimise or supress some of these responses. The aim of this study was to determine the timeline over which changes in appetite occur during progressive WL with a ketogenic very-low-energy diet (VLED). SUBJECTS/METHODS: Thirty-one sedentary adults (18 men), with obesity (body mass index: 37±4...
August 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
M S M Wee, R G Lentle, K K T Goh, L Matia-Merino
We examined the effect of gavage of 4 ml of a viscous shear-thickening polysaccharide solution (15% w/w) extracted from the fronds of the mamaku tree fern (Cythea medullaris) in reducing appetite and delaying gastric emptying in twenty six Sprague Dawley rats. After two weeks habituation to a pelleted chow, the rats were gavaged on alternate days with either the mamaku extract or with the same volume of deionised water for a total of five times over a period of two weeks. The body mass and food intake of each rat were determined daily and the weights of their stomach contents determined on euthanasia two hours after the final gavage...
December 22, 2016: Food & Function
David J Clayton, Lewis J James
The belief that breakfast is the most important meal of day has been derived from cross-sectional studies that have associated breakfast consumption with a lower BMI. This suggests that breakfast omission either leads to an increase in energy intake or a reduction in energy expenditure over the remainder of the day, resulting in a state of positive energy balance. However, observational studies do not imply causality. A number of intervention studies have been conducted, enabling more precise determination of breakfast manipulation on indices of energy balance...
August 2016: Proceedings of the Nutrition Society
Aisling M Lynch, Nupur Pathak, Yasmin E Flatt, Victor A Gault, Finbarr P M O'Harte, Nigel Irwin, Peter R Flatt
Oxyntomodulin (Oxm) possesses beneficial biological actions for the potential treatment of obesity-diabetes. However, rapid inactivation by dipeptidyl peptidase-4 (DPP-4) results in a short half-life, hindering therapeutic applicability. In the present study, six Oxm analogues namely, (Thr(2))Oxm, (Asp(3))Oxm, (Aib(2))Oxm, (d-Ser(2))Oxm, (N-acetyl)Oxm and (d-Ser(2))Oxm-Lys-γ-glutamyl-PAL were synthesised and tested for DPP-4 stability and biological activity. Native Oxm, (Thr(2))Oxm and (Asp(3))Oxm were rapidly degraded by DPP-4, while (Aib(2))Oxm, (d-Ser(2))Oxm, (N-acetyl)Oxm and (d-Ser(2))Oxm-Lys-γ-glutamyl-PAL were resistant to degradation...
November 15, 2014: European Journal of Pharmacology
Graeme Milligan, Trond Ulven, Hannah Murdoch, Brian D Hudson
It is becoming evident that nutrients and metabolic intermediates derived from such nutrients regulate cellular function by activating a number of cell-surface G-protein coupled receptors (GPCRs). Until now, members of the GPCR family have largely been considered as the molecular targets that communicate cellular signals initiated by hormones and neurotransmitters. Recently, based on tissue expression patterns of these receptors and the concept that they may elicit the production of a range of appetite- and hunger-regulating peptides, such nutrient sensing GPCRs are attracting considerable attention due to their potential to modulate satiety, improve glucose homeostasis and supress the production of various pro-inflammatory mediators...
June 2014: British Journal of Nutrition
Alan R Mackie, Hameed Rafiee, Paul Malcolm, Louise Salt, George van Aken
The aim of this study was to determine the extent to which gastric layering and retention of a meal could be used to reduce appetite using the same caloric load. Liquid (control) and semi-solid (active) meals were produced with the same protein, fat, carbohydrate, and mass. These were fed to 10 volunteers on separate days in a crossover study, and subjective appetite ratings, gastric contents, and plasma cholecystokinin (CCK) were assessed over a period of 3 h. The active meal showed food boluses in the stomach persisting for ~45 min, slower emptying rates, and lower plasma CCK levels over the first hour...
June 1, 2013: American Journal of Physiology. Gastrointestinal and Liver Physiology
Jéssica Sereno Peixoto, Jurandir Fernando Comar, Caroline Tessaro Moreira, Andréia Assunção Soares, Andrea Luiza de Oliveira, Adelar Bracht, Rosane Marina Peralta
The fruit extracts of Citrus aurantium (bitter orange) are traditionally used as weight-loss products and as appetite supressants. An important fruit component is p-synephrine, which is structurally similar to the adrenergic agents. Weight-loss and adrenergic actions are always related to metabolic changes and this work was designed to investigate a possible action of the C. aurantium extract on liver metabolism. The isolated perfused rat liver was used to measure catabolic and anabolic pathways, including oxygen uptake and perfusion pressure...
2012: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
A Balcioglu, R J Wurtman
OBJECTIVE: To measure the effects of phentermine, an appetite supressant, on the release of brain dopamine (DA) and serotonin (5-HT) into striatal dialysates of freely moving rats. DESIGN: Microdialysis and high performance liquid chromatography. SUBJECTS: Unanesthetized rats. MEASUREMENTS: Samples collected every 20 min were assayed for both neurotransmitters in a single run, using high performance liquid chromatography with electrochemical detection...
April 1998: International Journal of Obesity and related Metabolic Disorders
(no author information available yet)
No abstract text is available yet for this article.
November 6, 1970: Drug and Therapeutics Bulletin
E R Evans, M G Wallace
In a multi-centre trial of mazindol ('Teronac'), a new anorectic agent unrelated to amphetamine, 274 male and female patients were treated by 53 investigators in Eire. All patients were overweight according to the Metropolitan Life Assurance Company Tables, and 166 patients completed the treatment regime of one 2 mg. tablet daily and a 100 calorie diet for 12 weeks. The average weight loss was 18.8 lbs. (8.5 kg.); 85% of patients reported good appetite supression and good ability to adhere to their diet, and the attending physicians rated mazindol as being of considerable help in 92% of the patients...
1975: Current Medical Research and Opinion
E Abraham
Autopsy findings of an infant with sacral agenesis and multiple anomalies of the lower half of the body which fit the description of the caudal regression syndrome are reported. The lumbosacral plexus of nerves was more abundant on one side despite symmetrical lumbar vertebral dysgenesis with agenesis below S1. The presence of intrathecal kidney tissue has not been previously reported in this syndrome. Diethylopropion hydrochloride, an appetite supressant, which was ingested by the patient's mother during the first month of pregnancy, was cited as a possible etiologic agent...
November 1979: Clinical Orthopaedics and related Research
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"