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https://www.readbyqxmd.com/read/28266625/inhibition-of-phd3-by-salidroside-promotes-neovascularization-through-cell-cell-communications-mediated-by-muscle-secreted-angiogenic-factors
#1
Jing Zhang, Vivi Kasim, Yu-Dan Xie, Can Huang, Julita Sisjayawan, Agnes Dwi Ariyanti, Xue-Song Yan, Xiao-Yan Wu, Cai-Ping Liu, Li Yang, Makoto Miyagishi, Shou-Rong Wu
Therapeutic angiogenesis has been considered as a potential strategy for treating peripheral artery diseases including hind-limb ischemia (HLI); however, no effective drug-based treatment is currently available. Here we showed that intramuscular administration of salidroside, an active compound of Chinese herb Rhodiola, could robustly enhance blood perfusion recovery by promoting neovascularization in HLI mice. We revealed that salidroside promoted skeletal muscle cell migration and paracrine function through inhibiting the transcriptional level of prolyl-hydroxylase domain 3 (PHD3) without affecting PHD1 and PHD2...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28242935/trans-himalayan-rhodiola-imbricata-edgew-root-a-novel-source-of-dietary-amino-acids-fatty-acids-and-minerals
#2
Amol B Tayade, Priyanka Dhar, Jatinder Kumar, Manu Sharma, Om P Chaurasia, Ravi B Srivastava
Roots of Rhodiola imbricata Edgew from Indian trans-Himalayan cold desert known for their nutritional and medicinal attributes were evaluated for the dietary amino acids, fatty acids and mineral composition. Nine essential and twelve non-essential amino acids were quantified. The contents ranged between 91.33 and 1640.67 µg/g. Histidine (1434.33 µg/g), lysine (1329.33 µg/g) and threonine (1015.67 μg/g) were dominant essential amino acids, while glycine (1640.67 µg/g), proline (1263.67 µg/g), alanine (1142...
February 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28229589/production-of-cinnamyl-alcohol-glucoside-from-glucose-in-escherichia-coli
#3
Wei Zhou, Huiping Bi, Yibin Zhuang, Qinglin He, Hua Yin, Tao Liu, Yanhe Ma
Rosin, a cinnamyl alcohol glucoside, is one of the important ingredients in Rhodiola rosea, which is a valuable medicinal herb used for centuries. Rosin displayed multiple biological activities. The traditional method for producing rosin and derivatives is direct extraction from R. rosea, which suffers from limited availability of natural resources and complicated purification procedure. This work achieved de novo biosynthesis of rosin in Escherichia coli. First, a biosynthetic pathway of aglycon cinnamyl alcohol from phenylalanine was constructed...
March 1, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28219059/rhodiola-rosea-in-subjects-with-prolonged-or-chronic-fatigue-symptoms-results-of-an-open-label-clinical-trial
#4
Yevgeniya Lekomtseva, Irina Zhukova, Anna Wacker
BACKGROUND: Rhodiola rosea roots and rhizomes are a herbal medicine for temporary relief of stress symptoms such as fatigue and sensed weakness. A daily dosage of 400 mg is recommended. METHODS: A dry ethanolic extract of R. rosea (WS® 1375) was studied in 100 subjects with prolonged or chronic fatigue symptoms. In an uncontrolled, open-label multicenter clinical trial, the subjects were administered 2 × 200 mg WS® 1375 over 8 weeks. Outcome measures were scales and tests related to fatigue...
2017: Complement Med Res
https://www.readbyqxmd.com/read/28182623/evaluation-of-dna-barcodes-in-codonopsis-campanulaceae-and-in-some-large-angiosperm-plant-genera
#5
De-Yi Wang, Qiang Wang, Ying-Li Wang, Xiao-Guo Xiang, Lu-Qi Huang, Xiao-Hua Jin
DNA barcoding is expected to be one of the most promising tools in biological taxonomy. However, there have been no agreements on which core barcode should be used in plants, especially in species-rich genera with wide geographical distributions. To evaluate their discriminatory power in large genera, four of the most widely used DNA barcodes, including three plastid regions (matK, rbcL, trnH-psbA) and nuclear internal transcribed spacer (nrITS), were tested in seven species-rich genera (Ficus, Pedicularis, Rhodiola, Rhododendron,Viburnum, Dendrobium and Lysimachia) and a moderate size genus, Codonopsis...
2017: PloS One
https://www.readbyqxmd.com/read/28133891/the-effects-of-hydroporation-on-melasma-with-anti-aging-cocktail
#6
Je Byeong Chae, Seung Hye Yang, Sang Young Byun, Hye-Ryung Choi, Jung-Won Shin, Kyoung-Chan Park
BACKGROUND: Jet-M is a device for epidermal peeling and is used to deliver substances by spraying air and microdroplets. Previously, a case was treated with a mixed solution of copper-GHK, oligo-hyaluronic acid, Rhodiola extract, tranexamic acid, and β-glucan. The results showed significant improvement of aged skin. AIMS: This study was conducted to evaluate the effects of hydroporation on melasma with the formulation in a small group of volunteers. METHODS: Clinical effects were evaluated by both subjective and objective methods including melanin index (MI) and erythema index (EI) measurement...
January 29, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28106808/anti-fatigue-effects-of-the-unique-polysaccharide-marker-of-dendrobium-officinale-on-balb-c-mice
#7
Wei Wei, Zhi-Peng Li, Tong Zhu, Hau-Yee Fung, Tin-Long Wong, Xin Wen, Dik-Lung Ma, Chung-Hang Leung, Quan-Bin Han
Dendrobium officinale extract shows potent anti-fatigue effects; however, the active substance responsible for these effects remains undetermined. A glucomannan with a huge molecular size of 730 kDa, called DOP, was identified as the unique authentication marker of this expensive herb. DOP exhibited immunomodulating effects on macrophages and lymphocytes in our previous study. Clinical reports also showed that people with fatigue syndrome have a disturbed immune system. Because DOP is the unique and dominant component of D...
January 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28095073/preclinical-and-potential-applications-of-common-western-herbal-supplements-as-complementary-treatment-in-parkinson-s-disease
#8
Luke A Morgan, Oliver Grundmann
Parkinson's disease (PD) is a neurological disorder with a complex pathological etiology, which is not fully understood. Progression of PD may be the result of a buildup of iron in the substantia nigra, microglia-mediated neuroinflammation, dysfunctional mitochondria, or abnormal protein handling. Dopamine is the main neurotransmitter affected, but as the disease progresses, a decrease in all the brain's biogenic amines occurs. Current medication used in the treatment of PD aims to prevent the breakdown of dopamine or increase dopaminergic neurotransmission in the central nervous system...
July 4, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28081284/analysis-of-the-relationship-between-ribosomal-dna-its-sequences-and-active-components-in-rhodiola-plants
#9
D J Zhang, W T Yuan, M T Li, Y H Zhang
Rhodiola plants are a valuable resource in traditional Chinese medicine. The objective of this study was to evaluate the correlation between ribosomal DNA internal transcribed spacer (ITS) sequences and the three active components in Rhodiola plants. For this, we determined ITS sequence polymorphisms and the concentrations of active components salidroside, tyrosol, and gallic acid in different Rhodiola species from the Tibetan Plateau. In a total of 23 Rhodiola samples, 16 different haplotypes were defined based on their ITS sequences...
December 23, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28073099/golden-root-a-wholesome-treat-of-immunity
#10
REVIEW
Kunjan Khanna, K P Mishra, Lilly Ganju, Shashi Bala Singh
Rhodiola is native to the high altitude regions of Asia, Europe and Northern Hemisphere. It has a long history of use as a medicinal plant in various ailments, boosting immunity, increasing energy and mental capacity. It is also known as "Adaptogen" to help the body to adapt and resist stress. The part of the plant, which is used for medicinal values, is rhizome, which is an underground stem. The rhizome contains mainly salidroside, rosin, rosavin and p-tyrosol. There are many studies, which have reported the effects of Rhodiola spp...
March 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28061780/rhodiola-crenulata-extract-counteracts-the-effect-of-hypobaric-hypoxia-in-rat-heart-via-redirection-of-the-nitric-oxide-and-arginase-1-pathway
#11
Shih-Wei Hsu, Tsu-Chung Chang, Yu-Kuan Wu, Kuen-Tze Lin, Li-Shian Shi, Shih-Yu Lee
BACKGROUND: Rhodiola crenulata is traditionally used as a folk medicine in Tibet for preventing high-altitude illnesses, including sudden cardiac death (SCD). The cardio-protective effects of Rhodiola crenulata root extract (RCE) against hypoxia in vivo have been recently confirmed. However, the way in which RCE produces these effects remains unclear. The present study is designed to confirm the protective effects of RCE on the heart in acute hypobaric hypoxia exposure and examine the mechanisms by which this occurs...
January 7, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28054637/salidroside-promotes-peripheral-nerve-regeneration-based-on-tissue-engineering-strategy-using-schwann-cells-and-plga-in-vitro-and-in-vivo
#12
Hui Liu, Peizhen Lv, Yongjia Zhu, Huayu Wu, Kun Zhang, Fuben Xu, Li Zheng, Jinmin Zhao
Salidriside (SDS), a phenylpropanoid glycoside derived from Rhodiola rosea L, has been shown to be neuroprotective in many studies, which may be promising in nerve recovery. In this study, the neuroprotective effects of SDS on engineered nerve constructed by Schwann cells (SCs) and Poly (lactic-co-glycolic acid) (PLGA) were studied in vitro. We further investigated the effect of combinational therapy of SDS and PLGA/SCs based tissue engineering on peripheral nerve regeneration based on the rat model of nerve injury by sciatic transection...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28028844/improved-tlc-bioautographic-assay-for-qualitative-and-quantitative-estimation-of-tyrosinase-inhibitors-in-natural-products
#13
Jinge Zhou, Qingjiu Tang, Tao Wu, Zhihong Cheng
INTRODUCTION: TLC bioautography for tyrosinase inhibitors has made recent progress; however, an assay with a relative low consumption of enzyme and quantitative capability would greatly advance the efficacy of related TLC bioautographic assays. OBJECTIVE: An improved TLC bioautographic assay for detecting tyrosinase inhibitors was developed and validated in this study. METHODS: L-DOPA (better water-solubility than L-tyrosine) was used as the substrate instead of reported L-tyrosine...
March 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/27976225/comparison-of-different-rhodiola-species-using-nmr-metabolomics-and-hptlc-techniques
#14
A Booker, L Zhai, C Gkouva, S Li, D Frommenwiler, E Reich, A Slater, M Heinrich
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27976214/biotransformation-capacity-of-rhodiola-rosea-callus-culture-for-biosynthesis-of-rosavins
#15
I Mirmazloum, O González López, M Ladányi, Z György
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27975740/anti-fatigue-effects-of-rhodiola-rosea-extract
#16
S Y Choi
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27975550/rhodiola-rosea-a-potential-chinese-herbal-medicine-prevents-alzheimer-s-disease
#17
C H Wang, Y F Lin, C K Lee
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27955927/structure-activity-relationship-of-the-inhibitory-effects-of-flavonoids-on-nitric-oxide-production-in-raw264-7-cells
#18
Wen-Jun Jiang, Akihiro Daikonya, Mitsuyoshi Ohkawara, Takashi Nemoto, Ryusuke Noritake, Tomoko Takamiya, Susumu Kitanaka, Hiroshi Iijima
We isolated flavonoids from herbal specimens from the Tibetan region (Sophora yunnanensis and Rhodiola sacra) that suppress nitric oxide (NO) production in macrophages stimulated by lipopolysaccharide and interferon-γ. The isolated flavonoids carry symmetric substitutions in the B ring (R3'=R5'). We analyzed the quantitative structure-activity relationship of the inhibitory activity by comparative molecular field analysis (CoMFA) using this series of flavonoids. Use of flavonoids with symmetrical substitutions in the B ring made it simpler to align molecules because it was not necessary to consider a huge number of combinations due to the B-ring conformation...
January 15, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27942852/salidroside-accelerates-fracture-healing-through-cell-autonomous-and-non-autonomous-effects-on-osteoblasts
#19
Xiao Qin Guo, Lin Qi, Jing Yang, Yue Wang, Chuan Wang, Zong Min Li, Ling Li, Ye Qu, Dan Wang, Ze Min Han
Salidroside (SAL), a major active component of Rhodiola rosea L., exhibits diverse pharmacological effects. However, the direct roles of SAL in fracture healing remain largely unknown. Here, we demonstrate that SAL significantly promotes proliferation by altering the cell-cycle distribution of osteoblastic cells. SAL also greatly stimulates osteoblast differentiation and mineralization by inducing the expression of Runx2 and Osterix. In addition to its osteoblast-autonomous effects, SAL can activate the HIF-1α pathway coupling of angiogenesis and osteogenesis through cell-non-autonomous effects...
December 10, 2016: Cell and Tissue Research
https://www.readbyqxmd.com/read/27935764/morphofunctional-renal-alterations-in-progeny-of-mice-fed-rhodiola-kirilowii-extracts-or-epigallocatechin-during-pregnancy-and-lactation
#20
Sławomir Lewicki, Ewa Skopińska-Różewska, Barbara Joanna Bałan, Bolesław Kalicki, Janusz Patera, Jacek Wilczak, Aleksander Wasiutyński, Robert Zdanowski
Treating infections in pregnant patients is potentially dangerous even when herbal medicines are used. Many herbal medicines, among them extracts from plants of Rhodiola genus, have antimicrobial, anti-inflammatory, and immunostimulatory properties owing to their polyphenol content; they may, however, affect fetal development due to their antiangiogenic properties. The aim of this study was to explain whether daily feeding pregnant and lactating mice with 20 mg/kg Rhodiola kirilowii aqueous (RKW) or 50% hydro-alcoholic (RKW-A) extracts, or 0...
January 2017: Journal of Medicinal Food
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