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Jie Wang, Yan-Ling Zhang, Nan Zhuang
Salidroside is the major bioactive component of Rhodiola sachalinensis. Studies have shown that salidroside has anti-inflammatory effects. In the present study, we examined whether salidroside inhibited inflammatory reaction in BV-2 microglial cells and thereby inhibited PC12 apoptosis. BV-2 cells were induced by lipopolysaccharides (LPS, 100 μg/L) and/or salidroside (10 mg/L), and then the conditioned medium was collected. Real time-PCR was used to detect IL-6 and TNF-α mRNA expression. The contents of IL-6 and TNF-α in medium were detected by ELSIA...
June 25, 2018: Sheng Li Xue Bao: [Acta Physiologica Sinica]
Tao Li, Chen Su
Rhodiola is an increasingly widely used traditional Tibetan medicine and traditional Chinese medicine in China. The composition profiles of bioactive compounds are somewhat jagged according to different species, which makes it crucial to identify authentic Rhodiola species accurately so as to ensure clinical application of Rhodiola. In this paper, a nondestructive, rapid, and efficient method in classification of Rhodiola was developed by Fourier transform near-infrared (FT-NIR) spectroscopy combined with chemometrics analysis...
June 2, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Cai-Yun Zhao, Guo-Fu Jia, Zheng-Jun He, Qing-Fang Luo, Gang Fan, Yi Zhang, Wen-Ji Zhao
This study is aimed to explore the effect of nitrogen, phosphorus and potassium combined application on the active components of Rhodiola crenulata. R. crenulata was used as the research object, "3414" fertilization experiment were conducted with regular fertilization of NPK(N 60 kg·hm⁻², P₂O₅ 100 kg·hm⁻²,KCl 160 kg·hm⁻²) to study the effect of different rates of NPK fertilization on the total amount of 4 phenolic constituents of gallic acid, salidroside, tyrol and ethyl gallate through field test...
May 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Fang-Fang Fan, Fei-Fei Guo, Wen Zhang, Yi Zhang, Hong-Jun Yang, Yi Zhang, De-Feng Li, Jing Zhang, Jing-Jing Zhang
In this study, a computer-based network pharmacology approach was applied to investigate the potential mechanism and important components of Rhodiola crenulata in the protection of H9c2 cells against hydrogen peroxide (H₂O₂)-induced oxidative stress. The intestinal absorption liquid of R. crenulata enhanced the cell viability, maintained cell morphology and inhibited cell apoptosis in the H₂O₂-induced oxidative stress in H9c2. Then, computer-based network pharmacology was used to analyze the relevant mechanism...
May 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Dong Young Kang, Nipin Sp, Doh Hoon Kim, Youn Hee Joung, Hyo Gun Lee, Young Min Park, Young Mok Yang
The major hallmarks of tumor progression are angiogenesis, migration and metastasis. Among the components of Rhodiola rosea, salidroside (p‑hydroxyphenethyl-β‑d-glucoside) is one of the most potent, and is present in all Rhodiola species. Recent data have revealed the anticancer effects of salidroside; however, the mechanism underlying its ability to inhibit tumor angiogenesis remains unknown. The present study aimed to analyze how salidroside affects major factors involved in breast cancer, and to elucidate its ability to inhibit angiogenesis and invasion...
June 5, 2018: International Journal of Oncology
Wilfried Dimpfel, Leonie Schombert, Alexander G Panossian
Rhodiola rosea L. roots and rhizome extracts are active ingredients in adaptogenic herbal medicinal products (HMP) and dietary supplements for temporary relief of symptoms of stress, such as fatigue and weakness. R. rosea extract has a stimulating effect on the CNS, suggesting potential benefits on cognitive functions, memory, learning, and attention. The reproducible efficacy and quality of preparations of the underground parts of R. rosea depend on the highly variable content of the active markers, salidroside and rosavin, which affect the quality of HMP and dietary supplements...
2018: Frontiers in Pharmacology
Kaitlyn E Wong, Maria C Mora, Nazneen Sultana, Kevin P Moriarty, Richard B Arenas, Nagendra Yadava, Sallie S Schneider, Michael V Tirabassi
Outcomes of children with high grade neuroblastoma remain poor despite multi-agent chemotherapy regimens. Rhodiola crenulata extracts display anti-neoplastic properties against several cancers including breast cancer, melanoma, and glioblastoma. In this study, we evaluated the anti-neoplastic potential of Rhodiola crenulata extracts on human neuroblastoma cells. Through this work, cell viability and proliferation were evaluated following treatments with ethanol (vehicle control) or Rhodiola crenulata extract in neuroblastoma, NB-1691 or SK-N-AS cells, in vitro...
June 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Akiko Hashimoto-Hachiya, Gaku Tsuji, Mika Murai, Xianghong Yan, Masutaka Furue
Rhodiola species are antioxidative, salubrious plants that are known to inhibit oxidative stress induced by ultraviolet and γ-radiation in epidermal keratinocytes. As certain phytochemicals activate aryl hydrocarbon receptors (AHR) or OVO-like 1 (OVOL1) to upregulate the expression of epidermal barrier proteins such as filaggrin (FLG), loricrin (LOR), and involucrin (IVL), we investigated such regulation by Rhodiola crenulata root extract (RCE). We demonstrated that RCE induced FLG and LOR upregulation in an AHR-OVOL1-dependent fashion...
June 4, 2018: International Journal of Molecular Sciences
D Anheyer, H Haller, P Klose, H Cramer, G Dobos
BACKGROUND: In Germany herbal medicines are traditionally frequently used. They represent an important therapeutic option, especially in self-medication. METHODS: Current systematic review articles and meta-analyses were evaluated and summarized with respect to the evidence of phytotherapeutic drugs for selected psychiatric indications. RESULTS: Apart from the use of St. John's wort for depression, no other herb has so far shown convincing evidence...
May 30, 2018: Der Nervenarzt
Jiao Feng, Peiqin Niu, Kan Chen, Liwei Wu, Tong Liu, Shizan Xu, Jingjing Li, Sainan Li, Wenwen Wang, Xiya Lu, Qiang Yu, Ning Liu, Ling Xu, Fan Wang, Weiqi Dai, Yujing Xia, Xiaoming Fan, Chuanyong Guo
Salidroside (Sal) is a glycoside extract from Rhodiola rosea L. with anti-inflammatory, antioxidant, anticancer and cardioprotective properties. The present study explored the protective effects and the possible mechanisms of Sal on concanavalin A (ConA)-induced liver injury in mice. Balb/C mice were divided into five groups: Normal control (injected with normal saline), ConA (25 mg/kg), Sal (10 mg/kg) +ConA, Sal (20 mg/kg) + ConA (Sal injected 2 h prior to ConA injection) and Sal (20 mg/kg) only. The serum levels of liver enzymes, pro-inflammatory cytokines, and apoptosis- and autophagy-associated marker proteins were determined at 2, 8 and 24 h after ConA injection...
June 2018: Experimental and Therapeutic Medicine
Yao Xu, Huiyan Jiang, Congyong Sun, Michael Adu-Frimpong, Wenwen Deng, Jiangnan Yu, Ximing Xu
In this study, two polysaccharide fractions (RRP1: Mw = 5.5 kDa, and RRP2: Mw = 425.7 kDa) were isolated from Rhodiola rosea to investigate their antioxidation and hepatoprotective effects. Physicochemical analysis showed that RRP1 was composed of mannose, rhamnose, galacturonic acid, glucose, galactose and arabinose with a relative molar ratio of 0.69:0.11:0.15:1:0.51:7.5 and RRP2 was consisted of mannose, rhamnose, galacturonic acid, glucose, galactose and arabinose (relative molar ratio = 0...
May 23, 2018: International Journal of Biological Macromolecules
Zhilin Qi, Tuo Tang, Lili Sheng, Yunfei Ma, Yinhua Liu, Liang Yan, Shimei Qi, Liefeng Ling, Yao Zhang
Salidroside, an active ingredient extracted from the Rhodiola rosea plant, has potential anti‑tumor effects. However, the effects of salidroside on gastric cancer cell proliferation and migration remain unclear. In the present study, the inhibitory effects of salidroside on gastric cancer cell proliferation, migration and invasion and the molecular mechanisms underlying these effects were investigated. The human gastric cancer cell line, BGC‑823, was treated with different concentrations of salidroside (200, 400 and 600 µg/ml)...
May 3, 2018: Molecular Medicine Reports
Sahil Kapoor, Rinky Raghuvanshi, Pushpender Bhardwaj, Hemant Sood, Shweta Saxena, Om Prakash Chaurasia
Rhodiola imbricata is a rare medicinal herb well-known for its adaptogenic and antioxidant properties due to the presence of a diverse array of secondary metabolites, including phenylethanoids and phenylpropanoids. These secondary metabolites are generating considerable interest due to their potential applications in pharmaceutical and nutraceutical industries. The present study investigated the influence of light quality on growth, production of industrially important secondary metabolites and antioxidant activity in callus cultures of Rhodiola imbricata...
April 24, 2018: Journal of Photochemistry and Photobiology. B, Biology
Tao Li, Yang Feng, Ruixin Yang, Leitao Wu, Ruru Li, Lu Huang, Qian Yang, Jianzong Chen
Parkinson's disease (PD) is characterized by the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc) and the presence of Lewy bodies (LBs) in the surviving SNc neurons. LBs formation is caused by the accumulation of α-synuclein (α-syn) or phosphorylated α-syn at serine-129 (pSer129-α-syn), which is implicated in the pathological progression of PD. Salidroside (Sal), the main active ingredient of the root of Rhodiola rosea L ., has been reported to have potent neuroprotective properties in our previous investigations...
2018: Frontiers in Pharmacology
Jian-Qiang Zhang, Da-Lv Zhong, Wei-Jie Song, Ruo-Wei Zhu, Wei-Yue Sun
How geological events and climate oscillations in the Pleistocene glaciation shaped the geographic distribution of genetic variation of species on the Qinghai-Tibetan Plateau (QTP) and its adjacent areas has been extensively studied. However, little studies have investigated whether closely related species in the same genus with similar physiological and life history traits responded similarly to the glacial climatic oscillations. If this is not the case, we would expect that the population histories of studied species were not driven by extrinsic environmental changes alone...
2018: Frontiers in Plant Science
Ruo-Wei Zhu, Yuan-Cong Li, Da-Lv Zhong, Jian-Qiang Zhang
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
April 25, 2018: Scientific Reports
Ying-Hui Kong, Su-Ping Xu
Salidroside (SR) is a main component of Rhodiola rosea L. and exhibits a variety of pharmacologic properties. The present study was carried out to explore the potential effect of SR against skin cancer induced by 7,12-dimethylbenz(a)anthracene (DMBA) and 12-O-tetradecanoylphorbol-13‑acetate (TPA) in female Institute for Cancer Research (ICR) mice and to reveal the underlying molecular targets regulated by SR. The mice were randomly divided into 4 groups: control, DMBA/TPA, DMBA/TPA+SR (20 mg/kg) and DMBA/TPA+SR (40 mg/kg)...
June 2018: Oncology Reports
Peng Zhang, Yuanmin Li, Rong Guo, Wangfu Zang
BACKGROUND Salidroside, the major active compound in Rhodiola, has been reported to provide beneficial effects on cardiovascular diseases, but its effects on diabetes-induced vascular endothelial dysfunction are less known. Here, we examined the protective effects of salidroside on endothelial function in diabetes and explored the potential underlying mechanism. MATERIAL AND METHODS First, we assessed the endothelium-dependent relaxation response to acetylcholine, with or without salidroside treatment, in aortas isolated from Sprague-Dawley rats...
April 21, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Jianling You, Xiaoping Qin, Sailesh Ranjitkar, Stephen C Lougheed, Mingcheng Wang, Wen Zhou, Dongxin Ouyang, Yin Zhou, Jianchu Xu, Wenju Zhang, Yuguo Wang, Ji Yang, Zhiping Song
Climate change profoundly influences species distributions. These effects are evident in poleward latitudinal range shifts for many taxa, and upward altitudinal range shifts for alpine species, that resulted from increased annual global temperatures since the Last Glacial Maximum (LGM, ca. 22,000 BP). For the latter, the ultimate consequence of upward shifts may be extinction as species in the highest alpine ecosystems can migrate no further, a phenomenon often characterized as "nowhere to go". To predict responses to climate change of the alpine plants on the Qinghai-Tibetan Plateau (QTP), we used ecological niche modelling (ENM) to estimate the range shifts of 14 Rhodiola species, beginning with the Last Interglacial (ca...
April 12, 2018: Scientific Reports
Ge Yu, Na Li, Yan Zhao, Wei Wang, Xiao-Ling Feng
Salidroside is one of the most potent compounds extracted from the plant Rhodiola rosea , and its cardiovascular protective effects have been studied extensively. However, the role of salidroside in human ovarian carcinoma remains unknown. The aim of the current study was to investigate the effects of salidroside on the proliferation and apoptosis of SKOV3 and A2780 cells using MTT assay and acridine orange/ethidium bromide staining. Salidroside activated caspase-3 and upregulated the levels of apoptosis-inducing factor, Bcl-2-associated X and Bcl-2-associated death promoter (Bad) proteins...
May 2018: Oncology Letters
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