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https://www.readbyqxmd.com/read/28095073/preclinical-and-potential-applications-of-common-western-herbal-supplements-as-complementary-treatment-in-parkinson-s-disease
#1
Luke A Morgan, Oliver Grundmann
Parkinson's disease (PD) is a neurological disorder with a complex pathological etiology, which is not fully understood. Progression of PD may be the result of a buildup of iron in the substantia nigra, microglia-mediated neuroinflammation, dysfunctional mitochondria, or abnormal protein handling. Dopamine is the main neurotransmitter affected, but as the disease progresses, a decrease in all the brain's biogenic amines occurs. Current medication used in the treatment of PD aims to prevent the breakdown of dopamine or increase dopaminergic neurotransmission in the central nervous system...
January 17, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28081284/analysis-of-the-relationship-between-ribosomal-dna-its-sequences-and-active-components-in-rhodiola-plants
#2
D J Zhang, W T Yuan, M T Li, Y H Zhang
Rhodiola plants are a valuable resource in traditional Chinese medicine. The objective of this study was to evaluate the correlation between ribosomal DNA internal transcribed spacer (ITS) sequences and the three active components in Rhodiola plants. For this, we determined ITS sequence polymorphisms and the concentrations of active components salidroside, tyrosol, and gallic acid in different Rhodiola species from the Tibetan Plateau. In a total of 23 Rhodiola samples, 16 different haplotypes were defined based on their ITS sequences...
December 23, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28073099/golden-root-a-wholesome-treat-of-immunity
#3
REVIEW
Kunjan Khanna, K P Mishra, Lilly Ganju, Shashi Bala Singh
Rhodiola is native to the high altitude regions of Asia, Europe and Northern Hemisphere. It has a long history of use as a medicinal plant in various ailments, boosting immunity, increasing energy and mental capacity. It is also known as "Adaptogen" to help the body to adapt and resist stress. The part of the plant, which is used for medicinal values, is rhizome, which is an underground stem. The rhizome contains mainly salidroside, rosin, rosavin and p-tyrosol. There are many studies, which have reported the effects of Rhodiola spp...
January 7, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28061780/rhodiola-crenulata-extract-counteracts-the-effect-of-hypobaric-hypoxia-in-rat-heart-via-redirection-of-the-nitric-oxide-and-arginase-1-pathway
#4
Shih-Wei Hsu, Tsu-Chung Chang, Yu-Kuan Wu, Kuen-Tze Lin, Li-Shian Shi, Shih-Yu Lee
BACKGROUND: Rhodiola crenulata is traditionally used as a folk medicine in Tibet for preventing high-altitude illnesses, including sudden cardiac death (SCD). The cardio-protective effects of Rhodiola crenulata root extract (RCE) against hypoxia in vivo have been recently confirmed. However, the way in which RCE produces these effects remains unclear. The present study is designed to confirm the protective effects of RCE on the heart in acute hypobaric hypoxia exposure and examine the mechanisms by which this occurs...
January 7, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28054637/salidroside-promotes-peripheral-nerve-regeneration-based-on-tissue-engineering-strategy-using-schwann-cells-and-plga-in-vitro-and-in-vivo
#5
Hui Liu, Peizhen Lv, Yongjia Zhu, Huayu Wu, Kun Zhang, Fuben Xu, Li Zheng, Jinmin Zhao
Salidriside (SDS), a phenylpropanoid glycoside derived from Rhodiola rosea L, has been shown to be neuroprotective in many studies, which may be promising in nerve recovery. In this study, the neuroprotective effects of SDS on engineered nerve constructed by Schwann cells (SCs) and Poly (lactic-co-glycolic acid) (PLGA) were studied in vitro. We further investigated the effect of combinational therapy of SDS and PLGA/SCs based tissue engineering on peripheral nerve regeneration based on the rat model of nerve injury by sciatic transection...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28028844/improved-tlc-bioautographic-assay-for-qualitative-and-quantitative-estimation-of-tyrosinase-inhibitors-in-natural-products
#6
Jinge Zhou, Qingjiu Tang, Tao Wu, Zhihong Cheng
INTRODUCTION: TLC bioautography for tyrosinase inhibitors has made recent progress; however, an assay with a relative low consumption of enzyme and quantitative capability would greatly advance the efficacy of related TLC bioautographic assays. OBJECTIVE: An improved TLC bioautographic assay for detecting tyrosinase inhibitors was developed and validated in this study. METHODS: L-DOPA (better water-solubility than L-tyrosine) was used as the substrate instead of reported L-tyrosine...
December 28, 2016: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/27976225/comparison-of-different-rhodiola-species-using-nmr-metabolomics-and-hptlc-techniques
#7
A Booker, L Zhai, C Gkouva, S Li, D Frommenwiler, E Reich, A Slater, M Heinrich
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27976214/biotransformation-capacity-of-rhodiola-rosea-callus-culture-for-biosynthesis-of-rosavins
#8
I Mirmazloum, O González López, M Ladányi, Z György
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27975740/anti-fatigue-effects-of-rhodiola-rosea-extract
#9
S Y Choi
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27975550/rhodiola-rosea-a-potential-chinese-herbal-medicine-prevents-alzheimer-s-disease
#10
C H Wang, Y F Lin, C K Lee
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27955927/structure-activity-relationship-of-the-inhibitory-effects-of-flavonoids-on-nitric-oxide-production-in-raw264-7-cells
#11
Wen-Jun Jiang, Akihiro Daikonya, Mitsuyoshi Ohkawara, Takashi Nemoto, Ryusuke Noritake, Tomoko Takamiya, Susumu Kitanaka, Hiroshi Iijima
We isolated flavonoids from herbal specimens from the Tibetan region (Sophora yunnanensis and Rhodiola sacra) that suppress nitric oxide (NO) production in macrophages stimulated by lipopolysaccharide and interferon-γ. The isolated flavonoids carry symmetric substitutions in the B ring (R3'=R5'). We analyzed the quantitative structure-activity relationship of the inhibitory activity by comparative molecular field analysis (CoMFA) using this series of flavonoids. Use of flavonoids with symmetrical substitutions in the B ring made it simpler to align molecules because it was not necessary to consider a huge number of combinations due to the B-ring conformation...
January 15, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27942852/salidroside-accelerates-fracture-healing-through-cell-autonomous-and-non-autonomous-effects-on-osteoblasts
#12
Xiao Qin Guo, Lin Qi, Jing Yang, Yue Wang, Chuan Wang, Zong Min Li, Ling Li, Ye Qu, Dan Wang, Ze Min Han
Salidroside (SAL), a major active component of Rhodiola rosea L., exhibits diverse pharmacological effects. However, the direct roles of SAL in fracture healing remain largely unknown. Here, we demonstrate that SAL significantly promotes proliferation by altering the cell-cycle distribution of osteoblastic cells. SAL also greatly stimulates osteoblast differentiation and mineralization by inducing the expression of Runx2 and Osterix. In addition to its osteoblast-autonomous effects, SAL can activate the HIF-1α pathway coupling of angiogenesis and osteogenesis through cell-non-autonomous effects...
December 10, 2016: Cell and Tissue Research
https://www.readbyqxmd.com/read/27935764/morphofunctional-renal-alterations-in-progeny-of-mice-fed-rhodiola-kirilowii-extracts-or-epigallocatechin-during-pregnancy-and-lactation
#13
Sławomir Lewicki, Ewa Skopińska-Różewska, Barbara Joanna Bałan, Bolesław Kalicki, Janusz Patera, Jacek Wilczak, Aleksander Wasiutyński, Robert Zdanowski
Treating infections in pregnant patients is potentially dangerous even when herbal medicines are used. Many herbal medicines, among them extracts from plants of Rhodiola genus, have antimicrobial, anti-inflammatory, and immunostimulatory properties owing to their polyphenol content; they may, however, affect fetal development due to their antiangiogenic properties. The aim of this study was to explain whether daily feeding pregnant and lactating mice with 20 mg/kg Rhodiola kirilowii aqueous (RKW) or 50% hydro-alcoholic (RKW-A) extracts, or 0...
January 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/27933142/salidroside-reduces-tau-hyperphosphorylation-via-up-regulating-gsk-3%C3%AE-phosphorylation-in-a-tau-transgenic-drosophila-model-of-alzheimer-s-disease
#14
Bei Zhang, Qiongqiong Li, Xingkun Chu, Suya Sun, Shengdi Chen
BACKGROUND: Alzheimer's disease (AD) is an age-related and progressive neurodegenerative disease that causes substantial public health care burdens. Intensive efforts have been made to find effective and safe treatment against AD. Salidroside (Sal) is the main effective component of Rhodiola rosea L., which has several pharmacological activities. The objective of this study was to investigate the efficacy of Sal in the treatment of AD transgenic Drosophila and the associated mechanisms...
2016: Translational Neurodegeneration
https://www.readbyqxmd.com/read/27882178/modulatory-effects-of-feeding-pregnant-and-lactating-mice-rhodiola-kirilowii-extracts-on-the-immune-system-of-offspring
#15
Sławomir Lewicki, Barbara Joanna Bałan, Ewa Skopińska-Różewska, Robert Zdanowski, Marta Stelmasiak, Łukasz Szymański, Wanda Stankiewicz
Plants of Rhodiola genus are medicinal herbs that have a number of therapeutic properties, including anti-inflammatory and immunomodulatory activity. The present study aimed to determine whether the use Rhodiola kirilowii as an immunostimulant during pregnancy has an adverse effect on the development of the offspring immune system. Following mating, pregnant mice were placed in three groups that were fed during pregnancy and lactation with R. kirilowii aqueous extract (RKW; 20 mg/kg), R. kirilowii 50% hydro-alcoholic extract (RKW-A; 20 mg/kg) or water (control group), receiving water...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27854435/-rhodiola-rosea-and-its-neuropsychotropic-effects
#16
Jan Juřica, Tereza Koupá
The paper reviews the neuropsychotropic effects of Rhodiola rosea, a succulent perennial plant which is native to dry, high-altitude regions of the northern hemisphere. The most valued part of the plant is its rhizome, which has a rose-like fragrance. In the available literature, there is a large number of mentions of its healing properties; nonetheless, only few of them are based on reliable scientific evidence. Of the neuropsychotropic effects, there are mentions of anxiolytic, antidepressant, neuroprotective and pro- cognitive properties and nonspecific "adaptogenic" effects...
2016: Ceská a Slovenská Farmacie
https://www.readbyqxmd.com/read/27848900/antioxidative-effects-of-rhodiola-genus-phytochemistry-and-pharmacological-mechanisms-against-the-diseases
#17
Yongmei Li, Jue Wu, Ruixiu Shi, Na Li, Zhice Xu, Miao Sun
Rhodiola as one of traditional medicines has been used for clinical treatments due to their strong antioxidant properties. Phytochemical analysis revealed the presence of flavonoids, phenylpropanoids, phenylethanol/benzyl alcohol derivatives, cyanogenic glycosides and terpenoids. The bioactive compounds had been demonstrated to be effective at scavenging reactive oxygen species (ROS). The structures contain phenolic hydroxyl groups and unsaturated bonds. This article reviews antioxidant capacities of the extracts and bioactive components derived from Rhodiola plants...
November 16, 2016: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/27809414/salidroside-protects-against-homocysteine-induced-injury-in-human-umbilical-vein-endothelial-cells-via-the-regulation-of-endoplasmic-reticulum-stress
#18
Lin Zhu, Fang Jia, Jiang Wei, Yang Yu, Tianhong Yu, Yanjun Wang, Jianhui Sun, Guanghua Luo
INTRODUCTION: Previous studies showed that homocysteine (Hcy) could injure vascular endothelial cells via several mechanisms, including its promotion of oxidative stress pathway and endoplasmic reticulum stress (ER stress) pathway. Salidroside (SAL) is an active component of Rhodiola rosea with documented antioxidative properties. Emerging evidence conformed that SAL attenuated Hcy-induced endothelial dysfunction by reducing oxidative stress. However, its role in ER stress pathway remains unclarified...
February 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/27794583/comparative-study-on-the-protective-effects-of-salidroside-and-hypoxic-preconditioning-for-attenuating-anoxia-induced-apoptosis-in-pheochromocytoma-pc12-cells
#19
Yao Hu, Xiumei Lv, Jing Zhang, Xianli Meng
BACKGROUND Hypoxia is an important sign that can result from body injuries or a special condition such as being at a high altitude or deep water diving. In the current studies, hypoxic preconditioning (HPC) plays a key role in reducing hypoxia-induced apoptosis. We aimed to study the pharmacologic preconditioning effects of salidroside versus those of HPC in hypoxia-/anoxia-induced apoptosis in PC12 cells (pheochromocytoma). MATERIAL AND METHODS PC12 cells were treated by different experimental conditions: control condition, hypoxia condition, HPC condition, low-/middle-/high-dose condition of salidroside, cyclosporine A (CsA), and oratractyloside (ATR)...
October 30, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27779653/anti-inflammatory-effect-of-salidroside-on-phorbol-12-myristate-13-acetate-plus-a23187-mediated-inflammation-in-hmc-1-cells
#20
Da-Wun Yang, Ok-Hwa Kang, Young-Seob Lee, Sin-Hee Han, Sang-Won Lee, Seon-Woo Cha, Yun-Soo Seo, Su-Hyun Mun, Ryong Gong, Dong-Won Shin, Dong-Yeul Kwon
Salidroside [2-(4-hydroxyphenyl)ethyl β-D-gluco-pyranoside (SAS)] has been identified as the most potent ingredient of the plant Rhodiola rosea L. Previous studies have demonstrated that it possesses a number of pharmacological properties, including anti-aging, anti-fatigue, antioxidant, anticancer and anti-inflammatory properties. In this study, to ascertain the molecular mechanisms responsible for the anti-inflammatory activity of SAS, we used phorbol-12-myristate-13-acetate (PMA) plus A23187 to induce inflammation in human mast cell line-1 (HMC-1)...
December 2016: International Journal of Molecular Medicine
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