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Sarfaraz Ahmad Ejazi, Pradyot Bhattacharya, Md Asjad Karim Bakhteyar, Aquil Ahmad Mumtaz, Krishna Pandey, Vidya Nand Ravi Das, Pradeep Das, Mehebubar Rahaman, Rama Prosad Goswami, Nahid Ali
BACKGROUND: Visceral Leishmaniasis (VL), a severe parasitic disease, could be fatal if diagnosis and treatment is delayed. Post kala-azar dermal leishmaniasis (PKDL), a skin related outcome, is a potential reservoir for the spread of VL. Diagnostic tests available for VL such as tissue aspiration are invasive and painful although they are capable of evaluating the treatment response. Serological tests although less invasive than tissue aspiration are incompetent to assess cure. Parasitological examination of slit-skin smear along with the clinical symptoms is routinely used for diagnosis of PKDL...
October 2016: PLoS Neglected Tropical Diseases
Kerstin Jost, Mike Wendt, Aquiles Luna-Rodriguez, Andreas Löw, Thomas Jacobsen
In choice reaction time (RT) tasks, performance is often influenced by the presence of nominally irrelevant stimuli, referred to as distractors. Recent research provided evidence that distractor processing can be adjusted to the utility of the distractors: Distractors predictive of the upcoming target/response were more attended to and also elicited stronger motor responses. In an event-related potential (ERP) study, we investigated whether not only the extent of distractor processing (as suggested by these previous results), but also the timing of distractor-based response activation is subject to strategic control...
October 10, 2016: Journal of Experimental Psychology. Learning, Memory, and Cognition
C L Errando-Oyonarte, C Moreno-Sanz, P Vila-Caral, J C Ruiz de Adana-Belbel, E Vázquez-Alonso, J M Ramírez-Rodríguez, G Veiga-Ruiz, E Guasch-Arévalo, J I Lora-Tamayo D'Ocón
INTRODUCTION: Neuromuscular blockade enables airway management, ventilation and surgical procedures. However there is no national consensus on its routine clinical use. The objective was to establish the degree of agreement among anaesthesiologists and general surgeons on the clinical use of neuromuscular blockade in order to make recommendations to improve its use during surgical procedures. METHODS: Multidisciplinary consensus study in Spain. Anaesthesiologists experts in neuromuscular blockade management (n=65) and general surgeons (n=36) were included...
September 28, 2016: Revista Española de Anestesiología y Reanimación
Javier Moncayo-Arlandi, Eduard Guasch, Maria Sanz, Marta Casado, Nahuel Aquiles García, Lluis Mont, Marta Sitges, Ralph Knöll, Byambajav Buyandelger, Campuzano Oscar, Antonio Diez-Juan, Ramon Brugada
Arrhythmogenic cardiomyopathy (ACM) is a disorder characterized by a progressive ventricular myocardial replacement by fat and fibrosis which lead to ventricular arrhythmias and sudden cardiac death. Mutations in the desmosomal gene Plakophilin-2 (PKP2) accounts for >40% of all known mutations, generally causing a truncated protein. In a PKP2 truncated mouse model, we hypothesize that content of transgene, endurance training and aging will be determinant in disease progression. In addition, we investigated the molecular defects associated with the phenotype in this model...
July 12, 2016: Human Molecular Genetics
Bruno Prata Martinez, Anne Karine Menezes Santos Batista, Isis Resende Ramos, Júlio Cesar Dantas, Isabela Barboza Gomes, Luiz Alberto Forgiarini, Fernanda Rosa Warken Camelier, Aquiles Assunção Camelier
OBJECTIVE: The gait speed test (GST) is a physical test that can predict falls and aid in the diagnosis of sarcopenia in the elderly. However, to our knowledge, there have been no studies evaluating its reproducibility in hospitalized elderly patients. The objective of this study was to evaluate the safety and reproducibility of the six-meter GST (6GST) in hospitalized elderly patients. METHODS: This repeated measures study involved hospitalized elderly patients (≥ 60 years of age) who underwent the 6GST by the fifth day of hospitalization, were able to walk without assistance, and presented no signs of dyspnea or pain that would prevent them from performing the test...
May 2016: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
Akif Ahsan, Kush Manna, Gajraj S Yadav, Arsalan Moinuddin, Aquil Ahmad, R C Gupta, Sana Alam
BACKGROUND: >33% of the hypertensive Indians develops nephropathy. Proteinuria is an early indicator of nephropathy. Gold standard for determining proteinuria is 24-hour urinary protein excretion which is a troublesome task with poor patient compliance. Protein creatinine index (PCI) in a random urine sample has been advocated by some researchers as an alternative approach. Aim of this study was to evaluate the association of PCI with the severity and duration of hypertension, in North Indian population...
September 1, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
Aquiles Carattino, Saumyakanti Khatua, Michel Orrit
Single gold nanorods exhibit great opportunities for bio-sensing, enhanced spectroscopies and photothermal therapy. A key property of these particles is the surface plasmon resonance, that is strongly dependent on their shape. Methods for tuning this resonance after the synthesis of the particles are of great interest for many applications. In this work we show that, through very well known chemistry between gold atoms and cyanide ions, it is possible to tune the surface plasmon of single 25 × 50 nm rods by more than 100 nm towards longer wavelengths...
June 21, 2016: Physical Chemistry Chemical Physics: PCCP
Raúl Rojas, Aquiles Iglesias, Ferenc Bunta, Brian Goldstein, Claude Goldenberg, Leslie Reese
PURPOSE: The primary objective of this study was to investigate the relationship between language use with different interlocutors, maternal education level and the expressive language skills of US English learners (ELs) in Spanish and English. METHOD: Two hundred and twenty-four Spanish-speaking ELs in kindergarten provided narrative language samples in Spanish and English. Parents completed a questionnaire of maternal education level and language use with parents, older siblings and peers...
April 2016: International Journal of Speech-language Pathology
Jocélia P C Oliveira, Natália Salazar, Marcelo B Zani, Lucas R de Souza, Silvia G Passos, Aquiles M Sant'Ana, Regiane A de Andrade, Arlei Marcili, Marcia A Sperança, Luciano Puzer
Serine peptidase inhibitor (serpin) is the name given to the superfamily of proteins with wide range of biological functions, and that the main feature is the inhibition of serine proteases. Here we describe the inhibitory characterization of a serpin from Gloeobacter violaceus that we named vioserpin. The serpin presented a high specificity to inhibit trypsin-like enzymes with a rapid inhibition rate constant (2.1 × 10(6) M(-1) s(-1)). We also demonstrated that the inhibitory activity of the vioserpin is influenced by the concentration of heparin, and this finding may throw a new light on understanding the molecular evolution of serpins...
August 2016: Biochimie
A Matthew Prina, Daisy Acosta, Isaac Acostas, Mariella Guerra, Yueqin Huang, A T Jotheeswaran, Ivonne Z Jimenez-Velazquez, Zhaorui Liu, Juan J Llibre Rodriguez, Aquiles Salas, Ana Luisa Sosa, Joseph D Williams, Martin Prince
No abstract text is available yet for this article.
May 6, 2016: International Journal of Epidemiology
Aquiles Salas, Daisy Acosta, Cleusa P Ferri, Mariella Guerra, Yueqin Huang, K S Jacob, Ivonne Z Jimenez-Velazquez, Juan J Llibre Rodriguez, Ana L Sosa, Richard Uwakwe, Joseph D Williams, A T Jotheeswaran, Zhaorui Liu, A M Lopez Medina, Rosa Maria Salinas-Contreras, Martin J Prince
BACKGROUND: Little is known of the epidemiology of diabetes among older people in low and middle income countries. We aimed to study and compare prevalence, social patterning, correlates, detection, treatment and control of diabetes among older people in Latin America, India, China and Nigeria. METHODS: Cross-sectional surveys in 13 catchment area sites in nine countries. Diagnosed diabetes was assessed in all sites through self-reported diagnosis. Undiagnosed diabetes was assessed in seven Latin American sites through fasting blood samples (glucose > = 7 mmol/L)...
2016: PloS One
Aquil Ahmad, Arsalan Moinuddin, Akif Ahsan, Ashish Goel
INTRODUCTION: Neuropathy is one of the most troublesome complication affecting individuals with diabetes. The resultant loss of function in peripheral nerves causes loss of protective sensations and impairs patient's ability to perceive incipient or even apparent ulcerations in the feet. AIM: This study was undertaken to test the hypothesis of alteration in electrophysiological parameters of nerve before actual manifestations of neuropathy in type 2 diabetic patients and to analyse the effect of smoking on Sensory Nerve Conduction Velocity (SNCV) of diabetic subjects...
January 2016: Journal of Clinical and Diagnostic Research: JCDR
Mohammed S Al-Marhoon, Allal Ouhtit, Aisha O Al-Abri, Krishna P Venkiteswaran, Qassim Al-Busaidi, Josephkunju Mathew, Ibrahim Al-Haddabi, Omar Shareef, Shahid Aquil, Khalid Rahman, Intisar Al-Hashmi, Ishita Gupta, Shyam S Ganguly
OBJECTIVES: To determine whether Helicobacter pylori (H. pylori) is detectable in both benign prostatic hyperplasia (BPH) and prostate cancer (PCa). Epidemiological studies have shown significant associations between infective chronic prostatitis and prostatic carcinoma. Many bacteria have been found in the prostate of patients with chronic prostatitis, BPH, and PCa. METHODS: One hundred consecutive patients with prostate diseases were enrolled in the study. Detection of H...
September 2015: Current Urology
Arnoldo Aquino-Gálvez, Georgina González-Ávila, Javier Delgado-Tello, Manuel Castillejos-López, Criselda Mendoza-Milla, Joaquín Zúñiga, Marco Checa, Héctor Aquiles Maldonado-Martínez, Axel Trinidad-López, José Cisneros, Luz María Torres-Espíndola, Claudia Hernández-Jiménez, Bettina Sommer, Carlos Cabello-Gutiérrez, Luis H Gutiérrez-González
Hypoxic tumor cells are known to be more resistant to conventional chemotherapy and radiation than normoxic cells. However, the effects of 2-methoxyestradiol (2-ME), an anti-angiogenic, antiproliferative and pro-apoptotic drug, on hypoxic lung cancer cells are unknown. The aim of the present study was to compare the effects of 2-ME on cell growth, apoptosis, hypoxia-inducible factor 1α (HIF-1α) and HIF-2α gene and protein expression in A549 cells under normoxic and hypoxic conditions. To establish the optimal 2-ME concentration with which to carry out the apoptosis assay and to examine mRNA and protein expression of HIFs, cell growth analysis was carried out through N-hexa-methylpararosaniline staining assays in A549 cell cultures treated with one of five different 2-ME concentrations at different times under normoxic or hypoxic growth conditions...
January 2016: Oncology Reports
José Paz Marcelo Jiménez-Cruz, Jorge Elías Montoya-Pérez, Aquiles Valdespino-Estrada, Arturo Campos-Santaolalla, Luis Manuel Álvarez-Sánchez, Joaquín Gómez-León, Juan Francisco Arreguín-Porras
An aneurysm of the sinus of Valsalva is a rare cardiac anomaly (0.09% of cases in autopsy studies) . This article describes the case of a male patient, 58 years old with a history of smoking and surgery for the correction of sinus of Valsalva aneurysm 31 years before, with no record of approach or type of surgery. His condition began five months before his admission with atypical chest pain. Echocardiographic diagnosis of severe aortic regurgitation, finding recurrent aneurysm of sinus of Valsalva. Surgery was performed with primary closure of the defect and aortic valve replacement with mechanical prosthesis, issuing a favorable postoperative...
November 2015: Revista Médica del Instituto Mexicano del Seguro Social
John J Heilmann, Raúl Rojas, Aquiles Iglesias, Jon F Miller
BACKGROUND: Language sampling, recognized as a gold standard for expressive language assessment, is often elicited using wordless picture storybooks. A series of wordless storybooks, commonly referred to as 'Frog' stories, have been frequently used in language-based research with children from around the globe. AIMS: To examine the impact that differences in stories have on narrative output by comparing narrative productions across a series of five storybooks produced by 831 bilingual (Spanish-English) children in kindergarten through third grade...
May 2016: International Journal of Language & Communication Disorders
Aquiles Gareiso, Pedro Osvaldo Sagreras, Alejandro Petre
No abstract text is available yet for this article.
June 2015: Archivos Argentinos de Pediatría
Aquil Mirza Mohammed, Shuai Li
Redundancy resolution is a critical problem in the control of parallel Stewart platform. The redundancy endows us with extra design degree to improve system performance. In this paper, the kinematic control problem of Stewart platforms is formulated to a constrained quadratic programming. The Karush-Kuhn-Tucker conditions of the problem is obtained by considering the problem in its dual space, and then a dynamic neural network is designed to solve the optimization problem recurrently. Theoretical analysis reveals the global convergence of the employed dynamic neural network to the optimal solution in terms of the defined criteria...
July 2016: IEEE Transactions on Cybernetics
Jotheeswaran At, Renata Bryce, Matthew Prina, Daisy Acosta, Cleusa P Ferri, Mariella Guerra, Yueqin Huang, Juan J Llibre Rodriguez, Aquiles Salas, Ana Luisa Sosa, Joseph D Williams, Michael E Dewey, Isaac Acosta, Zhaorui Liu, John Beard, Martin Prince
BACKGROUND: In countries with high incomes, frailty indicators predict adverse outcomes in older people, despite a lack of consensus on definition or measurement. We tested the predictive validity of physical and multidimensional frailty phenotypes in settings in Latin America, India, and China. METHODS: Population-based cohort studies were conducted in catchment area sites in Cuba, Dominican Republic, Venezuela, Mexico, Peru, India, and China. Seven frailty indicators, namely gait speed, self-reported exhaustion, weight loss, low energy expenditure, undernutrition, cognitive, and sensory impairment were assessed to estimate frailty phenotypes...
2015: BMC Medicine
Bruno Prata Martinez, Isabela Barboza Gomes, Carolina Santana de Oliveira, Isis Resende Ramos, Mônica Diniz Marques Rocha, Luiz Alberto Forgiarini Júnior, Fernanda Warken Rosa Camelier, Aquiles Assunção Camelier
OBJECTIVES: The ability of the Timed Up and Go test to predict sarcopenia has not been evaluated previously. The objective of this study was to evaluate the accuracy of the Timed Up and Go test for predicting sarcopenia in elderly hospitalized patients. METHODS: This cross-sectional study analyzed 68 elderly patients (≥60 years of age) in a private hospital in the city of Salvador-BA, Brazil, between the 1st and 5th day of hospitalization. The predictive variable was the Timed Up and Go test score, and the outcome of interest was the presence of sarcopenia (reduced muscle mass associated with a reduction in handgrip strength and/or weak physical performance in a 6-m gait-speed test)...
May 2015: Clinics
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