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Botulinum toxin

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https://www.readbyqxmd.com/read/29332140/identification-of-cross-reactive-antigens-of-c-botulinum-types-a-b-e-f-by-immunoproteomic-approach
#1
Arti Sharma, Sarkaraisamy Ponmariappan, Rani Sarita, Syed Imtiaz Alam, Dev Vrat Kamboj, Sangeeta Shukla
Diseases triggered by microorganisms can be controlled by vaccines, which need neutralizing antigens. Hence, it is very crucial to identify extremely efficient immunogens for immune prevention. Botulism, a fatal neuroparalytic disease, is caused by botulinum neurotoxins produced by the anaerobic, Gram-positive spore-forming bacteria, Clostridium botulinum. Food-borne botulism and iatrogenic botulism are caused by botulinum toxin. Wound botulism, infant botulism, and adult intestinal botulism are caused by primarily C...
January 13, 2018: Current Microbiology
https://www.readbyqxmd.com/read/29329897/-botulinium-toxin-and-idiopathic-overactive-bladder-multicentric-contempory-management-in-bourgogne
#2
A Schneider, B Tourlonias, L Cormier, E Mourey, N Koutlidis, E Delorme, J Pasquale, I Kermarec, A-D Foahom-Kamwa, V Bonniaud
INTRODUCTION: Since 2014, OnabotulinumtoxinA Botox® (Allergan, Inc., Irvine, USA) represents a new therapeutic option for second-line treatment of idiopathic overactive bladder. The purpose of the current study was to evaluate practices of surgeons using onabotulinium toxin (BoNTA) in this indication. MATERIAL AND METHODS: All urogynecology centers of the country were asked in order to list all patients who were treated since marketing autorisation. Patient symptoms, previous treatments, paraclinic evaluations, data of surgery and the characteristics of the follow up were collected and analyzed...
January 9, 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/29327957/unusual-outbreak-of-fatal-clostridiosis-in-a-group-of-captive-brown-pelicans-pelecanus-occidentalis
#3
Imke Lueders, Carsten Ludwig, Johanna Kasberg, Christoph Georg Baums, Kerstin Klimke, Martin B Dorner, Dana Ströse, Volker Schmidt
Fatal clostridial infections and clostridial toxicoses are common in birds. Most fatalities are associated with toxin production and progress rapidly, often within 24 hours of infection. We describe an unusual and protracted course of disease in 6 captive brown pelicans ( Pelecanus occidentalis), which was believed to result from toxicosis by toxovar A produced by a mixed infection with Clostridium sordellii and Clostridium perfringens. Although the first death in the group occurred 3 days after signs of illness were documented, the remaining birds died over a 38-day period despite aggressive antibiotic and supportive therapy...
December 2017: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/29325384/-diagnosis-and-treatment-of-strabismus-caused-by-nasal-endoscopic-surgery
#4
L K Ai, X Wu, J N Wang, J Li, Y Wu, J Zhou, W X Song, R L Guo
Objective: Strabismus with diplopia is the main orbital complication of functional endoscopic sinus surgery (FESS). This study was to analyze clinical findings, treatment and outcomes of such cases. Methods: Retrospective case series. Twenty-three cases were divided into 3 groups based on the disease severity: group A, partial transection of the medial rectus muscle, group B, complete transection of the medical rectus, group C, transection of the medial rectus combined with the other orbital injuries. Complete ophthalmology examinations, including eye alignment, eye motility, force duction test, force generation test, general eye exam, and medical imaging (orbital CT or MRI), were performed for each case...
December 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29322963/botulinum-toxin-in-meige-s-syndrome-a-video-based-case-series
#5
Sanjay Pandey, Soumya Sharma
CONTEXT: Despite being the most common cause of cranial dystonia, Meige's syndrome remains a rare clinical entity. Characterized by blepharospasm and orofacial dystonia, patients suffering from Meige's syndrome benefit from the injection of botulinum toxin (BTX). AIMS: As the majority of the studies tend to discuss Meige's syndrome with blepharospasm patients, there is a paucity of case-based studies dealing exclusively with this syndrome. Hence, we intended to characterize and define the evolution of this syndrome and objectively determine the response of the patients suffering from this entity to BTX therapy...
January 2018: Neurology India
https://www.readbyqxmd.com/read/29322953/botulinum-toxin-in-patients-with-meige-s-syndrome
#6
Nirosen Vijiaratnam, Tissa Wijeratne
No abstract text is available yet for this article.
January 2018: Neurology India
https://www.readbyqxmd.com/read/29322885/analysis-of-a-15-years-experience-in-including-shoulder-muscles-when-treating-upper-limb-spasticity-post-stroke-with-botulinum-toxin-type-a
#7
Maria Pais de Carvalho, Daniela Pinto, Melissa Gorayeb, Jorge Jacinto
Background Botulinum toxin type-A (BoNTA) is a recognized treatment for upper limb spasticity (ULS) after stroke, but there aren't many studies analyzing its effect in shoulder muscles. Objective To evaluate the efficacy of BoNTA injections for ULS, when shoulder muscles are included. Methods A cross-sectional study. Data from clinical forms of outpatients, treated at a Rehabilitation Center (2001-2016). Analyzes: goals of treatment; demographic characteristics/goal; treatment success, using Goal Attainment Scaling...
January 11, 2018: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/29322402/laser-treatment-of-primary-axillary-hyperhidrosis-a-review-of-the-literature
#8
Jessica Cervantes, Marina Perper, Ariel E Eber, Raymond M Fertig, John P Tsatalis, Keyvan Nouri
Hyperhidrosis o`ccurs when the body produces sweat beyond what is essential to maintain thermal homeostasis. The condition tends to occur in areas marked by high-eccrine density such as the axillae, palms, and soles and less commonly in the craniofacial area. The current standard of care is topical aluminum chloride hexahydrate antiperspirant (10-20%), but other treatments such as anticholinergics, clonidine, propranolol, antiadrenergics, injections with attenuated botulinum toxin, microwave technology, and surgery have been therapeutically implicated as well...
January 11, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29320672/position-statement-a-clinical-approach-to-the-management-of-adult-non-neurogenic-overactive-bladder
#9
Eric Chung, Dominic Lee, Johan Gani, Michael Gillman, Christopher Maher, Janelle Brennan, Lydia Johns Putra, Laura Ahmad, Lewis Lw Chan
Overactive bladder (OAB) is a highly prevalent medical condition that has an adverse impact on various health-related quality-of-life domains, including a significant psychosocial and financial burden. This position statement, formulated by members of the Urological Society of Australia and New Zealand and the UroGynaecological Society of Australasia, summarises the current recommendations for clinical diagnosis and treatment strategies in patients with non-neurogenic OAB, and guides clinicians in the decision-making process for managing the condition using evidence-based medicine...
January 15, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/29320549/assessing-adverse-effects-of-intra-articular-botulinum-toxin-a-in-healthy-beagle-dogs-a-placebo-controlled-blinded-randomized-trial
#10
Helka M Heikkilä, Tarja S Jokinen, Pernilla Syrjä, Jouni Junnila, Anna Hielm-Björkman, Outi Laitinen-Vapaavuori
OBJECTIVE: To investigate the clinical, cytological, and histopathological adverse effects of intra-articularly injected botulinum toxin A in dogs and to study whether the toxin spreads from the joint after the injection. METHODS: A longitudinal, placebo-controlled, randomized clinical trial was conducted with six healthy laboratory Beagle dogs. Stifle joints were randomized to receive either 30 IU of onabotulinum toxin A or placebo in a 1:1 ratio. Adverse effects and spread of the toxin were examined by evaluating dynamic and static weight-bearing of the injected limbs, by assessing painless range of motion and pain on palpation of joints, and by performing synovial fluid analysis, neurological examination, and electrophysiological recordings at different examination time-points in a 12-week period after the injections...
2018: PloS One
https://www.readbyqxmd.com/read/29320379/botulinum-toxin-as-a-treatment-for-depression-in-a-real-world-setting
#11
Sanjay Chugh, Anjali Chhabria, Stefanie Jung, Tillmann H C Kruger, M Axel Wollmer
OBJECTIVES: A series of randomized controlled trials have shown the efficacy of glabellar botulinum toxin (BTX) injection as a treatment for depression in women. We wanted to extend these findings and assess how they may be translated to a real-world setting. METHODS: For that purpose, 42 patients with severe, in most cases chronic and treatment-resistant depression received adjunctive treatment with BTX in private practice. Depression severity was rated before and 3 weeks after the treatment using the Hamilton Depression Rating Scale, the Montgomery Åsberg Depression Rating Scale, and the Beck Depression Inventory...
January 2018: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/29319155/economic-evaluation-and-cost-of-interventions-for-cerebral-palsy-a-systematic-review
#12
REVIEW
Sophy T F Shih, Utsana Tonmukayakul, Christine Imms, Dinah Reddihough, H Kerr Graham, Liz Cox, Rob Carter
AIM: Economic appraisal can help guide policy-making for purchasing decisions, and treatment and management algorithms for health interventions. We conducted a systematic review of economic studies in cerebral palsy (CP) to inform future research. METHOD: Economic studies published since 1970 were identified from seven databases. Two reviewers independently screened abstracts and extracted data following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines...
January 10, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29315143/predictive-techniques-for-neurotoxin-outcomes
#13
Liza Brown, Drew Taylor, Eduardo Weiss
BACKGROUND: Botulinum-derived neurotoxins have become a substantial tool in dermatologists' armamentarium for facial/neck rejuvenation. Current literature discusses anatomical "danger zones" to avoid during neurotoxin injection to prevent brow ptosis, blepharoptosis, and lower facial ptosis. OBJECTIVE: The aim of this study was to determine whether lidocaine 1% local anesthetic can be used to predict botulinum toxin treatment outcomes and prevent adverse effects of unwanted paralysis...
January 8, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29309744/differential-endopeptidase-activity-of-different-forms-of-type-a-botulinum-neurotoxin-a-unique-relationship-between-the-size-of-the-substrate-and-activity-of-the-enzyme
#14
Ghuncha Ambrin, Raj Kumar, Bal Ram Singh
Botulinum neurotoxins (BoNTs; serotypes A-G) are metalloproteases, which cleave and inactivate cellular proteins essential for neurotransmitter release. In bacterial cultures, BoNTs are secreted as a complex of the neurotoxin and a group of neurotoxin associated proteins (NAPs). Under physiological condition (pH 7.4), this complex is believed to be dissociated to separate the neurotoxin from NAPs. BoNT consists of a 50 kDa light (L) chain (LC or catalytic domain) and a 100 kDa heavy (H) chain (or HC) linked through a disulfide bond and other non-covalent interactions...
January 5, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29309344/commentary-on-the-cellular-response-of-keloids-and-hypertrophic-scars-to-botulinum-toxin-a-a-comprehensive-literature-review
#15
Alastair Carruthers
No abstract text is available yet for this article.
January 5, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29307768/multidose-botulinum-toxin-a-for-intralaryngeal-injection-a-cost-analysis
#16
Mark R Gilbert, VyVy N Young, Libby J Smith, Clark A Rosen
OBJECTIVES: Botulinum toxin A (BtxA) injection is the mainstay treatment for laryngeal dystonias. BtxA product labeling states that reconstituted toxin should be used within 4 hours on a single patient despite several studies that have demonstrated multidose BtxA to be safe and effective. Many insurance carriers mandate the use of an outside pharmacy which necessitates a single-use approach. This study compares the cost savings of multidose BtxA for laryngeal dystonia compared to single-use...
January 4, 2018: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29307733/safety-and-feasibility-of-intravesical-instillation-of-botulinum-toxin-a-in-hydrogel-based-slow-release-delivery-system-in-interstitial-cystitis-bladder-pain-syndrome-patients-a-pilot-study
#17
Yishai H Rappaport, Amnon Zisman, Michal Jeshurun-Gutshtat, Tami Gerassi, Gil Hakim, Yuri Vinshtok, Kobi Stav
OBJECTIVE: To assess feasibility and safety of a mixture instillation of TC-3 Gel, a novel reverse-thermal gelation hydrogel, and botulinum toxin-A (BTX-A) for the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS). TC-3 Gel/BTX-A mix is instilled into the bladder as liquid, solidifies due to body heat and gradually dissolves to release BTX-A for several hours. METHODS: A single intravesical instillation of 200U BTX-A premixed with 40ml TC-3 Gel was delivered to the bladder...
January 4, 2018: Urology
https://www.readbyqxmd.com/read/29307477/enhancing-toxin-based-vaccines-against-botulism
#18
Amanda Przedpelski, William H Tepp, Madison Zuverink, Eric A Johnson, Sabine Pellet, Joseph T Barbieri
Botulinum neurotoxins (BoNT) are the most toxic proteins for humans. BoNTs are single chain proteins with an N-terminal light chain (LC) and a C-terminal heavy chain (HC). HC comprises a translocation domain (HCN) and a receptor binding domain (HCC). Currently, there are no approved vaccines against botulism. This study tests a recombinant, full-length BoNT/A1 versus LCHCN/A1 and HCC/A1 as vaccine candidates against botulism. Recombinant, full-length BoNT/A1 was detoxified by engineering 3-amino acid mutations (E224A/R363A/Y366F) (M-BoNT/A1) into the LC to eliminate catalytic activity, which reduced toxicity in a mouse model of botulism by >106-fold relative to native BoNT/A1...
January 4, 2018: Vaccine
https://www.readbyqxmd.com/read/29304876/a-systematic-review-efficacy-of-botulinum-toxin-in-walking-and-quality-of-life-in-post-stroke-lower-limb-spasticity
#19
Anupam Datta Gupta, Wing Hong Chu, Stuart Howell, Subhojit Chakraborty, Simon Koblar, Renuka Visvanathan, Ian Cameron, David Wilson
BACKGROUND: Improved walking is one of the highest priorities in people living with stroke. Post-stroke lower limb spasticity (PSLLS) impedes walking and quality of life (QOL). The understanding of the evidence of improved walking and QOL following botulinum toxin (BoNTA) injection is not clear. We performed a systematic review of the randomized control trials (RCT) to evaluate the effectiveness of BoNTA injection on walking and QOL in PSLLS. METHODS: We searched PubMed, Web of Science, Embase, CINAHL, ProQuest Thesis and Dissertation checks, Google Scholar, WHO International Clinical Trial Registry Platform, ClinicalTrials...
January 5, 2018: Systematic Reviews
https://www.readbyqxmd.com/read/29304272/botulinum-toxin-for-motor-and-phonic-tics-in-tourette-s-syndrome
#20
REVIEW
Sanjay Pandey, Prachaya Srivanitchapoom, Richard Kirubakaran, Brian D Berman
BACKGROUND: Gilles de la Tourette syndrome, or Tourette's syndrome, is defined as the presence of both motor and vocal (phonic) tics for more than 12 months, that manifest before the age of 18 years, in the absence of secondary causes. Treatment of motor and phonic tics is difficult and challenging. OBJECTIVES: To determine the safety and effectiveness of botulinum toxin in treating motor and phonic tics in people with Tourette's syndrome, and to analyse the effect of botulinum toxin on premonitory urge and sensory tics...
January 5, 2018: Cochrane Database of Systematic Reviews
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