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https://www.readbyqxmd.com/read/20100881/the-slit-robo-pathway-a-regulator-of-cell-function-with-implications-for-the-reproductive-system
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Rachel E Dickinson, W Colin Duncan
The secreted SLIT glycoproteins and their Roundabout (ROBO) receptors were originally identified as important axon guidance molecules. They function as a repulsive cue with an evolutionarily conserved role in preventing axons from migrating to inappropriate locations during the assembly of the nervous system. In addition the SLIT-ROBO interaction is involved in the regulation of cell migration, cell death and angiogenesis and, as such, has a pivotal role during the development of other tissues such as the lung, kidney, liver and breast...
April 2010: Reproduction: the Official Journal of the Society for the Study of Fertility
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