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https://www.readbyqxmd.com/read/29353393/131i-induced-graves-disease-in-patients-treated-for-toxic-multinodular-goitre-systematic-review-and-descriptive-analysis
#1
REVIEW
C Roque, C A Vasconcelos
BACKGROUND: Graves' disease (GD) arising after the treatment of toxic multinodular goitre (TMNG) with radioiodine has long been described but it remained unclear whether GD was in fact iodine induced, its incidence, risk factors, natural history and treatment outcomes. METHODS: A systematic search using The Cochrane Library, Medline and PubMed Central allowed the pooling of data from 3633 patients with thyroid autonomy, 1340 patients with TMNG, to fill gaps in knowledge, regarding the clinical expression of iodine-induced GD (131I-IGD) in adults...
January 20, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29346434/cognitive-distortions-and-gambling-near-misses-in-internet-gaming-disorder-a-preliminary-study
#2
Yin Wu, Guillaume Sescousse, Hongbo Yu, Luke Clark, Hong Li
Increased cognitive distortions (i.e. biased processing of chance, probability and skill) are a key psychopathological process in disordered gambling. The present study investigated state and trait aspects of cognitive distortions in 22 individuals with Internet Gaming Disorder (IGD) and 22 healthy controls. Participants completed the Gambling Related Cognitions Scale as a trait measure of cognitive distortions, and played a slot machine task delivering wins, near-misses and full-misses. Ratings of pleasure ("liking") and motivation to play ("wanting") were taken following the different outcomes, and gambling persistence was measured after a mandatory phase...
2018: PloS One
https://www.readbyqxmd.com/read/29343447/altered-b-lymphocyte-homeostasis-and-functions-in-systemic-sclerosis
#3
REVIEW
Alexandra Forestier, Thomas Guerrier, Mathieu Jouvray, Jonathan Giovannelli, Guillaume Lefèvre, Vincent Sobanski, Carine Hauspie, Eric Hachulla, Pierre-Yves Hatron, Hélène Zephir, Patrick Vermersch, Myriam Labalette, David Launay, Sylvain Dubucquoi
Beyond the production of autoantibodies, B-cells are thought to play a role in systemic sclerosis (SSc) by secreting proinflammatory/profibrotic cytokines. B-cells are a heterogeneous population with different subsets distinguished by their phenotypes and cytokine production. Data about B-cell subsets, cytokine production and intracellular pathways leading to this production are scarce in SSc. The aim of our study was to describe B-cell homeostasis, activation, proliferation, cytokine production in B-cells and serum and B-cell intracellular signaling pathways in SSc...
January 14, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29335579/the-effects-of-antibody-engineering-ch-and-cl-in-trastuzumab-and-pertuzumab-recombinant-models-impact-on-antibody-production-and-antigen-binding
#4
Wai-Heng Lua, Wei-Li Ling, Joshua Yi Yeo, Jun-Jie Poh, David Philip Lane, Samuel Ken-En Gan
Current therapeutic antibodies such as Trastuzumab, are typically of the blood circulatory IgG1 class (Cκ/ CHγ1). Due to the binding to Her2 also present on normal cell surfaces, side effects such as cardiac failure can sometimes be associated with such targeted therapy. Using antibody isotype swapping, it may be possible to reduce systemic circulation through increased tissue localization, thereby minimising unwanted side effects. However, the effects of such modifications have yet to be fully characterized, particularly with regards to their biophysical properties in antigen binding...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29325751/a-difficult-diagnosis-of-coeliac-disease-repeat-duodenal-histology-increases-diagnostic-yield-in-patients-with-concomitant-causes-of-villous-atrophy
#5
Gaetano Cristian Morreale, Luigi Maria Montalbano, Maria Cappello, Emanuele Sinagra, Aroldo Rizzo, Antonio Carroccio
Villous atrophy in absence of coeliac disease (CD)-specific antibodies represents a diagnostic dilemma. We report a case of a woman with anaemia, weight loss and diarrhoea with an initial diagnosis of seronegative CD and a histological documented villous atrophy who did not improve on gluten-free diet due to the concomitant presence of common variable immunodeficiency (CVID) and Giardia lamblia infection. This case report confirms that CD diagnosis in CVID patients is difficult; the combination of anti-endomysial antibodies (EmA-IgA), anti-tissue transglutaminase antibodies (tTG-IgAb) antibodies and total IgA is obligatory in basic diagnostic of CD but in CVID are negative...
January 8, 2018: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/29319177/characterization-of-ectopic-lymphoid-structures-in-different-types-of-acute-renal-allograft-rejection
#6
Kitty de Leur, Marian C Clahsen-van Groningen, Thierry P P van den Bosch, Gretchen N de Graav, Dennis A Hesselink, Janneke N Samsom, Carla C Baan, Karin Boer
BACKGROUND: We hypothesize that T cells such as IL-21+BCL6+ T follicular helper cells can regulate B cell mediated immunity within the allograft during acute T-cell mediated rejection, this process may feed chronic allograft rejection on long term. To investigate this mechanism we determined the presence and activation status of organized T and B cells in so-called ectopic lymphoid structures (ELSs) in different types of acute renal allograft rejection. METHODS: Biopsies showing the following primary diagnosis were included: acute/active antibody-mediated rejection, C4d+ (a/aABMR), acute T cell-mediated rejection grade I (aTCMRI), and acute T cell-mediated rejection grade II (aTCMRII)...
January 10, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29313730/the-immediate-and-long-term-effects-of-time-perspective-on-internet-gaming-disorder
#7
Kateřina Lukavská
Backgrounds and aims This study focuses on the role of time perspective (TP) in Internet gaming disorder (IGD). An inventory-based study on 377 massive multiplayer online role playing game players was conducted, followed by a 3-year-follow-up in which 48 active players from the original sample participated. We proposed that TP factors (negative TP and future positive TP) will influence either the current presence of IGD symptoms or the further development of IGD over time. In other words, the effect of TP is stable...
January 9, 2018: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/29306994/association-between-maternal-and-infantile-markers-of-cobalamin-status-during-the-first-month-post-delivery
#8
Sümeyra Çoban, Ebru Yılmaz Keskin, Mahir İğde
OBJECTIVE: Exclusively breast-fed infants born to vitamin B12 (cobalamin, cbl)-deficient mothers can develop symptoms within a few months following delivery. The authors aimed to assess the relationship between maternal and infantile markers of cbl status. METHODS: In 240 full-term infants (age, 2-30 d) admitted to Samsun Maternity and Child Health Hospital and their mothers, complete blood count testing and serum cbl, folate and plasma total homocysteine (tHcy) measurements were performed...
January 6, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29304199/intestinal-immune-responses-to-type-2-oral-polio-vaccine-opv-challenge-in-infants-previously-immunized-with-bivalent-opv-and-either-high-dose-or-standard-inactivated-polio-vaccine
#9
Elizabeth B Brickley, Carolyn B Strauch, Wendy F Wieland-Alter, Ruth I Connor, Shu Lin, Joshua A Weiner, Margaret E Ackerman, Minetaro Arita, M Steven Oberste, William C Weldon, Xavier Sáez-Llorens, Ananda S Bandyopadhyay, Peter F Wright
Background: The impact of inactivated polio vaccines (IPVs) on intestinal mucosal immune responses to live poliovirus is poorly understood. Methods: In a 2014 phase 2 clinical trial, Panamanian infants were immunized at 6, 10, and 14 weeks of age with bivalent oral polio vaccine (bOPV) and randomized to receive either a novel monovalent high-dose type 2-specific IPV (mIPV2HD) or a standard trivalent IPV at 14 weeks. Infants were challenged at 18 weeks with a monovalent type 2 oral polio vaccine (mOPV2)...
January 3, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29301261/detection-of-craving-for-gaming-in-adolescents-with-internet-gaming-disorder-using-multimodal-biosignals
#10
Hodam Kim, Jihyeon Ha, Won-Du Chang, Wanjoo Park, Laehyun Kim, Chang-Hwan Im
The increase in the number of adolescents with internet gaming disorder (IGD), a type of behavioral addiction is becoming an issue of public concern. Teaching adolescents to suppress their craving for gaming in daily life situations is one of the core strategies for treating IGD. Recent studies have demonstrated that computer-aided treatment methods, such as neurofeedback therapy, are effective in relieving the symptoms of a variety of addictions. When a computer-aided treatment strategy is applied to the treatment of IGD, detecting whether an individual is currently experiencing a craving for gaming is important...
January 1, 2018: Sensors
https://www.readbyqxmd.com/read/29300896/a-competitive-alphascreen-assay-for-detection-of-hyaluronan
#11
Xiayun Huang, Tannin A Schmidt, Claire Shortt, Shivani Arora, Akira Asari, Thorsten Kirsch, Mary K Cowman
A method for specific quantification of hyaluronan (HA) concentration using AlphaScreen® (Amplified Luminescent Proximity Homogeneous Assay) technology is described. Two types of hydrogel-coated and chromophore-loaded latex nanobeads are employed. The proximity of the beads in solution is detected by excitation of the donor bead leading to the production of singlet oxygen, and chemiluminescence from the acceptor bead upon exposure to singlet oxygen. In the HA assay, the donor bead is modified with streptavidin, and binds biotin-labeled HA...
December 29, 2017: Glycobiology
https://www.readbyqxmd.com/read/29296635/proinflammatory-b-cell-profile-in-the-early-phases-of-ms-predicts-an-active-disease
#12
Thomas Guerrier, Myriam Labalette, David Launay, Catalina Lee-Chang, Olivier Outteryck, Guillaume Lefèvre, Patrick Vermersch, Sylvain Dubucquoi, Hélène Zéphir
Objective: To assess whether any alteration of B-cell subset distribution and/or the cytokine production capacities of B cells could be associated with any stage of MS and could be predictive of MS evolution. Methods: We prospectively enrolled radiologically isolated syndrome (RIS), clinically isolated syndrome (CIS), naive patients with relapsing remitting MS (RRMS) of any disease modifying drug, and healthy controls (HCs). Peripheral blood B-cell subset distributions and the interleukin (IL)-6/IL-10-producing B-cell ratio were assessed by flow cytometry to evaluate their proinflammatory and anti-inflammatory functional properties...
March 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29295597/emotional-regulation-in-young-adults-with-internet-gaming-disorder
#13
Ju-Yu Yen, Yi-Chun Yeh, Peng-Wei Wang, Tai-Ling Liu, Yun-Yu Chen, Chih-Hung Ko
People diagnosed with Internet gaming disorder (IGD) have been frequently reported to experience depression, anxiety, and hostility. Emotional regulation contributes to these mood symptoms. This study evaluated emotional regulation in subjects with IGD and examined relationships between emotional regulation, depression, anxiety, and hostility in young adults with IGD. We recruited 87 people with IGD and a control group of 87 people without a history of IGD. All participants underwent a diagnostic interview based on the IGD criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, and they completed a questionnaire on emotional regulation, depression, anxiety, and hostility...
December 25, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29280953/risk-factors-for-internet-gaming-disorder-psychological-factors-and-internet-gaming-characteristics
#14
Mi Jung Rho, Hyeseon Lee, Taek-Ho Lee, Hyun Cho, Dong Jin Jung, Dai-Jin Kim, In Young Choi
Background: Understanding the risk factors associated with Internet gaming disorder (IGD) is important to predict and diagnose the condition. The purpose of this study is to identify risk factors that predict IGD based on psychological factors and Internet gaming characteristics; Methods: Online surveys were conducted between 26 November and 26 December 2014. There were 3568 Korean Internet game users among a total of 5003 respondents. We identified 481 IGD gamers and 3087 normal Internet gamers, based on Diagnostic and Statistical Manual for Mental Disorders (DSM-5) criteria...
December 27, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29280398/association-between-internet-gaming-disorder-and-generalized-anxiety-disorder
#15
Chao-Yang Wang, Yu-Chen Wu, Chen-Hsiang Su, Pai-Cheng Lin, Chih-Hung Ko, Ju-Yu Yen
Introduction This study evaluates the association between generalized anxiety disorder (GAD) and Internet gaming disorder (IGD) and the role of behavior inhibition in young adults. Methods We recruited 87 people with IGD and a control group of 87 people without a history of IGD. All participants underwent a diagnostic interview based on the fifth edition of Diagnostic and Statistical Manual of Mental Disorders, IGD and GAD criteria, and completed a questionnaire on behavior inhibition, depression, and anxiety...
December 1, 2017: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/29280397/measures-of-behavioral-function-predict-duration-of-video-game-play-utilization-of-the-video-game-functional-assessment-revised
#16
Frank D Buono, Mark D Griffiths, Matthew E Sprong, Daniel P Lloyd, Ryan M Sullivan, Thomas D Upton
Background Internet gaming disorder (IGD) was introduced in the DSM-5 as a way of identifying and diagnosing problematic video game play. However, the use of the diagnosis is constrained, as it shares criteria with other addictive orders (e.g., pathological gambling). Aims Further work is required to better understand IGD. One potential avenue of investigation is IGD's relationship to the primary reinforcing behavioral functions. This study explores the relationship between duration of video game play and the reinforcing behavioral functions that may motivate or maintain video gaming...
December 1, 2017: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/29280393/internet-gaming-disorder-and-online-gambling-disorder-clinical-and-personality-correlates
#17
Nuria Mallorquí-Bagué, Fernando Fernández-Aranda, María Lozano-Madrid, Roser Granero, Gemma Mestre-Bach, Marta Baño, Amparo Del Pino-Gutiérrez, Mónica Gómez-Peña, Neus Aymamí, José M Menchón, Susana Jiménez-Murcia
Background and aims The recent growth of Internet use has led to an increase of potentially problematic behaviors that can be engaged online, such as online gambling or Internet gaming. The aim of this study is to better conceptualize Internet gaming disorder (IGD) by comparing it with gambling disorder (GD) patients who only gamble online (online GD). Methods A total of 288 adult patients (261 online GD and 27 IGD) completed self-reported questionnaires for exploring psychopathological symptoms, food addiction (FA), and personality traits...
December 1, 2017: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/29249989/the-2d-4d-marker-and-different-forms-of-internet-use-disorder
#18
Marko Müller, Matthias Brand, Julia Mies, Bernd Lachmann, Rayna Yordanova Sariyska, Christian Montag
Internet use disorder (IUD) presents a growing problem worldwide. Among others, it manifests in loss of control over Internet usage and social problems due to problematic Internet use. Although IUD currently is not an official diagnosis in DSM-5 or ICD-10, mounting evidence suggests that IUD indeed could be categorized as a behavioral addiction. On a systemic neuroscientific level, IUD is well characterized and dysfunctions in the fronto-striatal-limbic loop have been observed in persons being afflicted with IUD...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29242101/epigenetic-silencing-of-evl-mir-342-in-multiple-myeloma
#19
Zhenhai Li, Kwan Yeung Wong, Godfrey Chi-Fung Chan, Wee-Joo Chng, Chor Sang Chim
miR-342-3p, localized to 14q32, is a tumor suppressor miRNA implicated in multiple cancers. As the promoter region of its host gene, EVL, is embedded in a CpG island, we postulated that miR-342-3p is an intronic miRNA co-regulated with its host gene by promoter DNA methylation in multiple myeloma (MM). By methylation-specific polymerase chain reaction, verified by quantitative bisulfite pyrosequencing, methylation of EVL/miR-342 was absent in all healthy controls (n = 10) and 12 of 15 (80%) human myeloma cell lines (HMCLs), but partially methylated in 3 of 15 (20%) HMCLs, including KMS-12-PE, OCI-MY5, and RPMI-8226R...
November 23, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/29240768/the-association-between-the-nicotinic-acetylcholine-receptor-%C3%AE-4-subunit-gene-chrna4-rs1044396-and-internet-gaming-disorder-in-korean-male-adults
#20
Jo-Eun Jeong, Je-Keun Rhee, Tae-Min Kim, Su-Min Kwak, Sol-Hee Bang, Hyun Cho, Young-Hoon Cheon, Jung Ah Min, Gil Sang Yoo, Kyudong Kim, Jung-Seok Choi, Sam-Wook Choi, Dai-Jin Kim
The primary aim of this study was to investigate the genetic predisposition of Internet gaming disorder (IGD), and the secondary aim was to compare the results to those of alcohol dependence (AD). Two independent case-control studies were conducted. A total of 30 male participants with IGD, diagnosed according to the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria, and 30 sex-matched controls participated in study 1. We designed targeted exome sequencing (TES) to test for 72 candidate genes that have been implicated in the pathogenesis of addiction...
2017: PloS One
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