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https://www.readbyqxmd.com/read/28938229/prevalence-and-correlates-of-comorbid-depression-in-a-nonclinical-online-sample-with-dsm-5-internet-gaming-disorder
#1
Hee Ryung Wang, Hyun Cho, Dai-Jin Kim
BACKGROUND: We investigated the prevalence and correlates of comorbid depression among patients with internet gaming disorder using the Internet Gaming Disorder scale (IGD-9) and the Patient Health Questionnaire-9 (PHQ-9) among nonclinical online survey respondents. METHODS: Korean adolescents and adults from 14 to 39 years of age were selected. We compared internet gaming use patterns and sociodemographic and clinical variables between patients with internet gaming disorder who had depression and those without depression...
August 10, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28932581/catch-me-if-you-can-how-to-make-the-best-use-of-pleural-effusion
#2
Lianjun Lin, Qian Han, Zhonghui Liu, Huiying Xu, Yanping Wu, Jixin Zhang, Xinmin Liu
Etiology diagnosis of pleural effusion is a commonly encountered yet challenging problem. How to make the best use of pleural effusion evokes thinking. Myelomatous pleural effusion (MPE) is a rare condition and has been reported sporadically. We report an extremely rare case of multiple myeloma (MM) [IgD-lambda (λ) type, stage III B] with MPE as initial presentation and complicated with massive pericardial effusions during the progression of the disease. Cytological identification of malignant plasma cells in pleural effusion is the most direct method to diagnose MPE...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28931676/protective-humoral-immunity-in-the-cns-requires-peripheral-cd19-dependent-germinal-center-formation-following-coronavirus-encephalomyelitis
#3
Jeffrey R Atkinson, Cornelia C Bergmann
B cell subsets with phenotypes characteristic of naïve, non-isotype-switched, memory (Bmem), and antibody-secreting cells (ASC) accumulate in various models of central nervous system (CNS) inflammation, including viral encephalomyelitis. During neurotropic coronavirus JHMV infection infiltration of protective ASC occurs after T cell mediated viral control, and is preceded by accumulation of non-isotype switched IgD(+) and IgM(+) B cells. However, the contribution of peripheral activation events in cervical lymph nodes (CLN) in driving humoral immune responses in the infected CNS is poorly defined...
September 20, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28928744/ccctc-binding-factor-locks-premature-igh-germline-transcription-and-restrains-class-switch-recombination
#4
Ester Marina-Zárate, Arantxa Pérez-García, Almudena R Ramiro
In response to antigenic stimulation B cells undergo class switch recombination (CSR) at the immunoglobulin heavy chain (IgH) to replace the primary IgM/IgD isotypes by IgG, IgE, or IgA. CSR is initiated by activation-induced cytidine deaminase (AID) through the deamination of cytosine residues at the switch (S) regions of IgH. B cell stimulation promotes germline transcription (GLT) of specific S regions, a necessary event prior to CSR because it facilitates AID access to S regions. Here, we show that CCCTC-binding factor (CTCF)-deficient mice are severely impaired in the generation of germinal center B cells and plasma cells after immunization in vivo, most likely due to impaired cell survival...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28922523/mature-b-cells-accelerate-wound-healing-after-acute-and-chronic-diabetic-skin-lesions
#5
Ruxandra F Sîrbulescu, Chloe K Boehm, Erin Soon, Moses Q Wilks, Iulian Ilieş, Hushan Yuan, Ben Maxner, Nicolas Chronos, Charalambos Kaittanis, Marc D Normandin, Georges El Fakhri, Dennis P Orgill, Ann E Sluder, Mark C Poznansky
Chronic wounds affect 12-15% of patients with diabetes and are associated with a drastic decrease in their quality of life. Here we demonstrate that purified mature naïve B220(+) /CD19(+) /IgM(+) /IgD(+) B cells improve healing of acute and diabetic murine wounds after a single topical application. B cell treatment significantly accelerated acute wound closure by 2-3 days in wild-type mice and 5-6 days in obese diabetic mice. The treatment led to full closure in 43% of chronic diabetic wounds, as compared to only 5% in saline-treated controls...
September 18, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28921996/treatments-for-internet-gaming-disorder-and-internet-addiction-a-systematic-review
#6
Kristyn Zajac, Meredith K Ginley, Rocio Chang, Nancy M Petry
Problems related to excessive use of the Internet and video games have recently captured the interests of both researchers and clinicians. The goals of this review are to summarize the literature on treatment effectiveness for these problems and to determine whether any treatments meet the minimum requirement of an evidence-based treatment as defined by Chambless et al. (1998). Studies of treatments for Internet gaming disorder (IGD) and Internet addiction were examined separately, as past studies have linked IGD to more severe outcomes...
September 18, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/28886017/b-cell-phenotype-and-igd-cd27-memory-b-cells-are-affected-by-tnf-inhibitors-and-tocilizumab-treatment-in-rheumatoid-arthritis
#7
Rita A Moura, Cláudia Quaresma, Ana R Vieira, Maria J Gonçalves, Joaquim Polido-Pereira, Vasco C Romão, Nádia Martins, Helena Canhão, João E Fonseca
BACKGROUND: The use of TNF-inhibitors and/or the IL-6 receptor antagonist, tocilizumab, in rheumatoid arthritis (RA) have pleiotropic effects that also involve circulating B-cells. The main goal of this study was to assess the effect of TNF-inhibitors and tocilizumab on B-cell phenotype and gene expression in RA. METHODS: Blood samples were collected from untreated early RA (ERA) patients, established RA patients under methotrexate treatment, established RA patients before and after treatment with TNF-inhibitors and tocilizumab, and healthy donors...
2017: PloS One
https://www.readbyqxmd.com/read/28885359/sustained-dysfunctional-information-processing-in-patients-with-internet-gaming-disorder-6-month-follow-up-erp-study
#8
Minkyung Park, Yeon Jin Kim, Dai Jin Kim, Jung-Seok Choi
Internet gaming disorder (IGD), defined as an inability to control Internet-based game play, leads to serious impairment in psychological and social functioning, but few studies have identified the neurophysiological characteristics of patients with IGD. The aim of this study was to determine neurophysiological markers of P300 components associated with changes in symptoms after outpatient management with pharmacotherapy in patients with IGD. The present prospective longitudinal study included 18 patients with IGD and 29 healthy controls...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28884950/abnormal-gray-matter-volume-and-impulsivity-in-young-adults-with-internet-gaming-disorder
#9
Deokjong Lee, Kee Namkoong, Junghan Lee, Young-Chul Jung
Reduced executive control is one of the central components of model on the development and maintenance of Internet gaming disorder (IGD). Among the various executive control problems, high impulsivity has consistently been associated with IGD. We performed voxel-based morphometric analysis with diffeomorphic anatomical registration by using an exponentiated Lie algebra algorithm (DARTEL) to investigate the relationship of gray matter abnormalities to impulsivity in IGD. Thirty-one young male adults whose excessive Internet gaming began in early adolescence, and 30 age-matched male healthy controls were examined...
September 8, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28877365/molecular-cloning-characterization-and-expression-of-immunoglobulin-d-igd-on-pathogen-challenge-and-pamps-stimulation-in-freshwater-carp-catla-catla
#10
Rajanya Banerjee, Bhakti Patel, Madhubanti Basu, Saswati S Lenka, Mahismita Paicha, Mrinal Samanta, Surajit Das
The primordial immunoglobulin class, IgD is the first non-IgM isotype discovered in teleosts. The crucial role of IgM and IgZ in imparting systemic and mucosal immunity respectively has been widely established in various fish species. However, the putative function of unique IgD isotype during pathogenic invasions has not been explored much. The present study reports the existence of IgD ortholog in freshwater carp, Catla catla and further evaluates its differential expression profile in response to bacterial, parasitic, viral antigenic exposure and (pathogen associated molecular patterns) PAMPs stimulations...
September 6, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/28872550/methionine-pet-might-be-reliable-for-the-detection-of-low-m-protein-producing-myelomas
#11
Osamu Imataki, Shumpei Uchida, Shigeyuki Yokokura, Makiko Uemura, Norimitsu Kadowaki
C-methionine (MET) positron emission tomography (PET) is more sensitive than F-fluorodeoxyglucose (FDG)-PET for detecting myeloma lesion. Many clinical studies support this evidence mainly for multiple myeloma cases of IgG or IgA subtypes. However, this is not confirmed for low monoclonal protein-producing myelomas, such as IgD, IgE, and nonsecretory type. We encountered a 71-year-old man with IgD λ-type myeloma. In this patient, FDG-PET did not reveal any abnormal uptake lesions, whereas MET-PET revealed diffuse bone marrow uptake that relieved after initial chemotherapy...
September 1, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28857427/the-extent-of-b-cell-activation-and-dysfunction-preceding-lymphoma-development-in-hiv-positive-people
#12
L Shepherd, Á H Borges, R Harvey, M Bower, A Grulich, M Silverberg, J Weber, M Ristola, J-P Viard, J R Bogner, P Gargalianos-Kakolyris, C Mussini, K Mansinho, I Yust, D Paduta, D Jilich, T Smiatacz, R Radoi, J Tomazic, P Plomgaard, R Frikke-Schmidt, J Lundgren, A Mocroft
OBJECTIVES: B-cell dysfunction and activation are thought to contribute to lymphoma development in HIV-positive people; however, the mechanisms are not well understood. We investigated levels of several markers of B-cell dysfunction [free light chain (FLC)-κ, FLC-λ, immunoglobulin G (IgG), IgA, IgM and IgD] prior to lymphoma diagnosis in HIV-positive people. METHODS: A nested matched case-control study was carried out within the EuroSIDA cohort, including 73 HIV-positive people with lymphoma and 143 HIV-positive lymphoma-free controls...
August 31, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28846748/plasmacytoid-dendritic-cells-and-rna-containing-immune-complexes-drive-expansion-of-peripheral-b-cell-subsets-with-an-sle-like-phenotype
#13
Olof Berggren, Niklas Hagberg, Andrei Alexsson, Gert Weber, Lars Rönnblom, Maija-Leena Eloranta
BACKGROUND: Hyperactive B cells and a continuous interferon (IFN)-α production by plasmacytoid dendritic cells (pDCs) play a key role in systemic lupus erythematosus (SLE). We asked whether the interaction between B cells and pDCs stimulated with RNA-containing immune complexes affects peripheral B cell subsets. METHODS: B cells and pDCs were isolated from blood of healthy individuals and stimulated with immune complexes consisting of SLE-IgG and U1snRNP (RNA-IC)...
2017: PloS One
https://www.readbyqxmd.com/read/28845377/an-extremely-rare-manifestation-of-multiple-myeloma-an-immunoglobulin-d-secreting-testicular-plasmacytoma
#14
Ashish Sharma, Tina Binazir, Alexandre Sintow, Chi Chan Lee, Sameer Shaharyar, Jason Tache
Multiple myelomas (MM) of the immunoglobulin D (IgD) subtype is rare amongst plasma cell malignancies. It can present a diagnostic challenge because of the low amount of immunoglobulin in the serum. The amount of monoclonal (M)-protein is often undetectable on electrophoresis. Historically, survival in these patients was typically shorter compared to the immunoglobulin A (IgA) and immunoglobulin G (IgG) subtypes due to advanced disease upon presentation. With the advent of better diagnostic techniques, the prognosis of this disease is changing...
June 27, 2017: Curēus
https://www.readbyqxmd.com/read/28842185/early-diagnosis-of-pi3k%C3%AE-syndrome-in-a-2-years-old-girl-with-recurrent-otitis-and-enlarged-spleen
#15
F Saettini, M A Pelagatti, D Sala, D Moratto, S Giliani, R Badolato, A Biondi
Heterozygous gain of function mutations in the gene encoding p110δ subunit of PI3K have been recently associated with activated PI3K-δ syndrome (APDS), a novel combined immune deficiency characterized by recurrent sinopulmonary infections, lymphopenia, reduced class-switched memory B cells, lymphadenopathy, CMV and/or EBV viremia and EBV-related lymphoma. Here we report a dominant gain of function PIK3CD mutation (E1021K) in a patient presenting with recurrent otitis media, massive splenomegaly, and persistent EBV-viraemia...
August 31, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28841491/video-game-addiction-in-emerging-adulthood-cross-sectional-evidence-of-pathology-in-video-game-addicts-as-compared-to-matched-healthy-controls
#16
Laura Stockdale, Sarah M Coyne
BACKGROUND: The Internet Gaming Disorder Scale (IGDS) is a widely used measure of video game addiction, a pathology affecting a small percentage of all people who play video games. Emerging adult males are significantly more likely to be video game addicts. Few researchers have examined how people who qualify as video game addicts based on the IGDS compared to matched controls based on age, gender, race, and marital status. METHOD: The current study compared IGDS video game addicts to matched non-addicts in terms of their mental, physical, social-emotional health using self-report, survey methods...
August 18, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28837939/measurement-invariance-of-the-internet-gaming-disorder-scale-short-form-igds9-sf-between-the-united-states-of-america-india-and-the-united-kingdom
#17
Halley M Pontes, Vasileios Stavropoulos, Mark D Griffiths
The Internet Gaming Disorder Scale-Short-Form (IGDS9-SF) has been extensively used worldwide to assess Internet Gaming Disorder (IGD) behaviors. Therefore, investigating cultural limitations and implications in its applicability is necessary. The cross-cultural feasibility of a test can be psychometrically evaluated with measurement invariance analyses. Thus, the present study used Multigroup Confirmatory Factor Analysis (MGCFA) to examine the IGDS9-SF measurement invariance across gamers from the United States of America (USA), India, and the United Kingdom (UK)...
August 12, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28832642/the-remnant-of-the-european-rabbit-oryctolagus-cuniculus-igd-gene
#18
Dennis K Lanning, Pedro J Esteves, Katherine L Knight
Although IgD first appeared, along with IgM, in the cartilaginous fishes and has been retained throughout subsequent vertebrate evolution, it has been lost in a diverse group of vertebrate species. We previously showed that, unlike vertebrates that express IgD, the rabbit lacks an IgD (Cδ) gene within 13.5 kb downstream of the IgM gene. We report here that, by conducting BLAST searches of rabbit Ig heavy chain genomic DNA with known mammalian IgD exons, we identified the remnant of the rabbit Cδ gene approximately 21 kb downstream of the IgM gene...
2017: PloS One
https://www.readbyqxmd.com/read/28831146/differential-neurophysiological-correlates-of-information-processing-in-internet-gaming-disorder-and-alcohol-use-disorder-measured-by-event-related-potentials
#19
Minkyung Park, Yeon Jin Kim, Dai Jin Kim, Jung-Seok Choi
Internet gaming disorder (IGD) shares clinical and neuropsychological features with alcohol use disorder (AUD), but few studies have identified the neurophysiological characteristics of IGD. We investigated the N100 and P300 event-related potentials (ERPs) in patients with IGD to compare them with those of patients with AUD and healthy controls (HCs). Twenty-six patients with IGD, 22 patients with AUD, and 29 HCs participated in this study. ERPs were acquired from young male adults during an auditory oddball task...
August 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28828214/diffusion-tensor-imaging-of-the-structural-integrity-of-white-matter-correlates-with-impulsivity-in-adolescents-with-internet-gaming-disorder
#20
Xin Du, Linlin Liu, Yongxin Yang, Xin Qi, Peihong Gao, Yang Zhang, Jiyu Zhu, Guijin Du, Shouping Dai, Xiaodong Li, Quan Zhang
INTRODUCTION: Internet gaming disorder (IGD) is usually defined as the inability of an individual to control internet gaming resulting in serious negative consequences, and trait impulsivity has been viewed as a hallmark feature of IGD. Recent studies have suggested that the structural integrity of the white matter (WM) plays an important role in the neuromediation of an individual's impulsivity. However, no study has examined the association between WM integrity and impulsivity in IGD adolescents...
August 2017: Brain and Behavior
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