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https://www.readbyqxmd.com/read/28732781/immunoglobulin-and-b-cell-disturbances-in-patients-with-chronic-idiopathic-neutropenia
#1
Irene Mavroudi, Aristides G Eliopoulos, Charalampos Pontikoglou, Katerina Pyrovolaki, Athina Damianaki, Helen Koutala, Maria I Zervou, Maria Ximeri, Semeli Mastrodemou, Peggy Kanellou, George N Goulielmos, Helen A Papadaki
Chronic idiopathic neutropenia (CIN) is a granulocytic disorder associated with presence of activated, myelosuppressive T-lymphocytes. In the present study we have evaluated constituents of humoral immunity in CIN patients (n=48) compared to healthy controls (n=52). CIN patients displayed lower serum IgG levels due to a reduction in IgG1, IgG3, IgG4 but not IgG2, lower IgA and increased IgM levels compared to controls. The proportion of CD19(+) cells did not differ between patients and controls; however the proportion of the naïve IgD(+)/CD27(-) B-cells was increased and the proportion of class-switched memory IgD(-)/CD27(+) B-cells was decreased in the patients...
July 18, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28720860/altered-hippocampal-volume-and-functional-connectivity-in-males-with-internet-gaming-disorder-comparing-to-those-with-alcohol-use-disorder
#2
Eun Jin Yoon, Jung-Seok Choi, Heejung Kim, Bo Kyung Sohn, Hee Yeon Jung, Jun-Young Lee, Dai-Jin Kim, Sun-Won Park, Yu Kyeong Kim
Internet gaming disorder (IGD) has been conceptualized as a behavioral addiction and shares clinical, neuropsychological, and personality characteristics with alcohol use disorder (AUD), but IGD dose not entail brain exposure to toxic agents, which renders it different from AUD. To achieve a clear understanding of the neurobiological features of IGD, we aimed to identify morphological and functional changes in IGD and compare them with those in AUD. Individuals with IGD showed larger volume in the hippocampus/amygdala and precuneus than healthy controls (HCs)...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28715266/associations-of-social-support-friends-only-known-through-the-internet-and-health-related-quality-of-life-with-internet-gaming-disorder-in-adolescence
#3
Lutz Wartberg, Levente Kriston, Rudolf Kammerl
Internet Gaming Disorder (IGD) has been included in the current edition of the Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (DSM-5). In the present study, the relationship among social support, friends only known through the Internet, health-related quality of life, and IGD in adolescence was explored for the first time. For this purpose, 1,095 adolescents aged from 12 to 14 years were surveyed with a standardized questionnaire concerning IGD, self-perceived social support, proportion of friends only known through the Internet, and health-related quality of life...
July 2017: Cyberpsychology, Behavior and Social Networking
https://www.readbyqxmd.com/read/28694074/memory-b-cell-resurgence-requires-repeated-rituximab-in-myasthenia-gravis
#4
Kohei Muto, Naoko Matsui, Yuki Unai, Waka Sakai, Shotaro Haji, Kengo Udaka, Hirokazu Miki, Takahiro Furukawa, Masahiro Abe, Ryuji Kaji
The immunologic effects of rituximab (RTX) in myasthenia gravis (MG) remain to be explored. We aimed to clarify immunologic reactions and their association with response to RTX in MG. Regulatory T cell and B cell profiles of MG patients were monitored. Two patients presenting with generalized MG with anti-acetylcholine receptor antibodies were treated with RTX. The treatment led to sustained clinical improvement, discontinuation of intravenous immunoglobulin or plasma exchange, and reduction of prednisolone and other drugs...
June 21, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/28690849/altered-regulatory-t-cell-fractions-and-helios-expression-in-clinically-isolated-syndrome-clues-to-the-development-of-multiple-sclerosis
#5
Anderson P Jones, Stephanie Trend, Scott N Byrne, Marzena J Fabis-Pedrini, Sian Geldenhuys, David Nolan, David R Booth, William M Carroll, Robyn M Lucas, Allan G Kermode, Prue H Hart
Development of multiple sclerosis (MS) is frequently preceded by an acute or subacute neurological disturbance referred to as clinically isolated syndrome (CIS). The specific immunological disturbances present in CIS remain underexamined. This study analysed peripheral blood mononuclear cells from n=18 treatment-naive individuals with recently diagnosed CIS (<120 days) for disturbances in the phenotype of T regulatory (Treg), follicular T regulatory (Tfr), T helper (Th), follicular T helper (Tfh) and B cells...
May 2017: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/28690578/unconscious-processing-of-facial-expressions-in-individuals-with-internet-gaming-disorder
#6
Xiaozhe Peng, Fang Cui, Ting Wang, Can Jiao
Internet Gaming Disorder (IGD) is characterized by impairments in social communication and the avoidance of social contact. Facial expression processing is the basis of social communication. However, few studies have investigated how individuals with IGD process facial expressions, and whether they have deficits in emotional facial processing remains unclear. The aim of the present study was to explore these two issues by investigating the time course of emotional facial processing in individuals with IGD. A backward masking task was used to investigate the differences between individuals with IGD and normal controls (NC) in the processing of subliminally presented facial expressions (sad, happy, and neutral) with event-related potentials (ERPs)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28683852/the-prevalence-and-psychosocial-correlates-of-internet-gaming-disorder
#7
Lutz Wartberg, Levente Kriston, Rainer Thomasius
BACKGROUND: Internet gaming disorder (IGD) is the problematic use of computer games (whether online or offline) Its prevalence throughout Germany among children, adolescents, and young adults has not yet been estimated. METHODS: A representative sample of 1531 12- to 25-yearolds in Germany was studied in September 2016 with a standardized instrument (Internet Gaming Disorder Scale, IGDS). Sociodemographic and psychosocial data about the participants were also obtained...
June 23, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28679445/coculture-of-bovine-cartilage-with-synovium-and-fibrous-joint-capsule-increases-aggrecanase-and-matrix-metalloproteinase-activity
#8
Per Swärd, Yang Wang, Maria Hansson, L Stefan Lohmander, Alan J Grodzinsky, André Struglics
BACKGROUND: A hallmark of osteoarthritis is increased proteolytic cleavage of aggrecan. Cross talk between cartilage and the synovium + joint capsule (SJC) can drive cartilage degradation by activating proteases in both tissues. We investigated aggrecan proteolysis patterns in cartilage explants using a physiologically relevant explant model of joint injury combining cartilage mechanical compression and coincubation with SJC. METHODS: Bovine cartilage explants were untreated; coincubated with SJC; or subjected to mechanical injury and coincubated with SJC, mechanical injury alone, or mechanical injury and incubated with tumor necrosis factor-α (TNF-α)...
July 5, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28662619/dsm-5-diagnosis-of-internet-gaming-disorder-some-ways-forward-in-overcoming-issues-and-concerns-in-the-gaming-studies-field
#9
Daria J Kuss, Mark D Griffiths, Halley M Pontes
Background and aims The current DSM-5 diagnosis of Internet Gaming Disorder (IGD; American Psychiatric Association [APA], 2013) has led to a number of issues and concerns that we highlighted in our recent paper (Kuss, Griffiths, & Pontes, 2017). Experts in the field responded to our evaluation of these issues resulting in six commentaries. Methods In this paper, we offer responses to the six commentaries to move the scientific field forward. All of the responses to our original paper highlighted many conceptual, theoretical, and/or methodological problems with the proposed IGD diagnosis as outlined in the DSM-5...
June 1, 2017: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/28662617/both-sides-of-the-story-addiction-is-not-a-pastime-activity
#10
Kai W Müller, Klaus Wölfling
The proposed inclusion of Internet gaming disorder (IGD) into the upcoming ICD-11 has caused mixed reactions. Having a sound diagnostic framework for defining this new phenomenon has been applauded but concerns have risen regarding overpathologizing a mere pastime activity. The review by Aarseth et al. (2016) provides a fine but one-sided impression on IGD. What has been totally left out in the argumentation is the clinical perspective. Although the concerns depicted must not be ignored, the conclusion provided by the authors is reflecting quite subjective speculations while objectivity would rather be needful...
June 1, 2017: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/28658960/the-influence-of-game-genre-on-internet-gaming-disorder
#11
Euihyeon Na, Inyoung Choi, Taek-Ho Lee, Hyeseon Lee, Mi Jung Rho, Hyun Cho, Dong Jin Jung, Dai-Jin Kim
Background and aims Although Internet gaming disorder (IGD) has been investigated in detail, minimal research has been conducted regarding the influence of different game genres on IGD. The aim of this study is to compare the characteristics of members of game genre-specific groups with IGD and to identify factors associated with IGD status in each group in a large sample of adults. Methods Internet games were categorized into four genres: real-time strategy games, massive multiplayer online role-playing games (MMORPG), sport games, and first-person shooter (FPS) games...
June 29, 2017: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/28646731/the-adaptive-decision-making-risky-decision-and-decision-making-style-of-internet-gaming-disorder
#12
C-H Ko, P-W Wang, T-L Liu, C-S Chen, C-F Yen, J-Y Yen
BACKGROUND: Persistent gaming, despite acknowledgment of its negative consequences, is a major criterion for individuals with Internet gaming disorder (IGD). This study evaluated the adaptive decision-making, risky decision, and decision-making style of individuals with IGD. METHODS: We recruited 87 individuals with IGD and 87 without IGD (matched controls). All participants underwent an interview based on the Diagnostic and Statistical Manual of Mental Disorders (5th Edition) diagnostic criteria for IGD and completed an adaptive decision-making task; the Preference for Intuition and Deliberation Scale, Chen Internet Addiction Scale, and Barratt Impulsivity Scale were also assessed on the basis of the information from the diagnostic interviews...
May 25, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28638818/effects-of-anakinra-on-health-related-quality-of-life-in-a-patient-with-1129g-a-928g-a-mutations-in-mvk-gene-and-heterozygosity-for-the-mutation-2107c-a-in-cias1-gene
#13
Gianluigi Laccetta, Maria Tutera, Mario Miccoli, Rita Consolini
Mevalonate kinase deficiency impairs several aspects of the patient's quality of life, thus early diagnosis and treatment are required to improve health-related quality of life (HRQOL). A 15-year-old patient with double heterozygosity for the mutations 1129G>A and 928G>A in MVK gene, heterozygosity for the mutation 2107C>A in CIAS1 gene and hyper-IgD syndrome phenotype, has been treated with anakinra with a reduction of 50% in the number of fever episodes per month, a reduction of 33% in the days of fever for each attack and normal blood tests in the intercritical phase...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28626947/pharmacokinetic-study-of-bortezomib-administered-intravenously-in-taiwanese-patients-with-multiple-myeloma
#14
Shang-Yi Huang, Cheng-Shyong Chang, Ta-Chih Liu, Po-Nan Wang, Su-Peng Yeh, Ching-Liang Ho, Ming-Chung Kuo, Hsuan-Yu Lin, Jan de Jong, Jia-Yi Chen, Ya-Wen Yang
This phase 4, single-arm, non-randomized, open-label, post approval commitment study evaluated the pharmacokinetics and safety of bortezomib in Taiwanese patients with multiple myeloma. Patients (≥20 years) with measurable secretory multiple myeloma (serum monoclonal IgG ≥10, IgA/IgE ≥5, IgD ≥0.5 g/L, IgM present [regardless of level], and urine M protein of ≥200 mg/24 h) received intravenous bortezomib 1.3 mg/m(2) , twice weekly for 2 weeks, followed by a 10-day resting phase (days 12 to 21)...
June 19, 2017: Hematological Oncology
https://www.readbyqxmd.com/read/28626065/metabolic-reprogramming-commits-differentiation-of-human-cd27-igd-b-cells-to-plasmablasts-or-cd27-igd-cells
#15
Masataka Torigoe, Shigeru Iwata, Shingo Nakayamada, Kei Sakata, Mingzeng Zhang, Maiko Hajime, Yusuke Miyazaki, Manabu Narisawa, Koji Ishii, Hirotaka Shibata, Yoshiya Tanaka
B cells play a crucial role in the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus (SLE). However, the relevance of the metabolic pathway in the differentiation of human B cell subsets remains unknown. In this article, we show that the combination of CpG/TLR9 and IFN-α markedly induced the differentiation of CD27(+)IgD(+) unswitched memory B cells into CD27(hi)CD38(hi) plasmablasts. The response was accompanied by mammalian target of rapamycin complex 1 (mTORC1) activation and increased lactate production, indicating a shift to glycolysis...
June 16, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28625807/evidence-for-altered-levels-of-immunoglobulin-d-in-the-nasal-airway-mucosa-of-patients-with-chronic-rhinosinusitis
#16
Jin-Young Min, Jayakar V Nayak, Kathryn E Hulse, Whitney W Stevens, Paul A Raju, Julia H Huang, Lydia A Suh, Griet A Van Roey, James E Norton, Roderick G Carter, Caroline P E Price, Ava R Weibman, Ali R Rashan, Eliver E Ghosn, Zara M Patel, Tetsuya Homma, David B Conley, Kevin C Welch, Stephanie Shintani-Smith, Anju T Peters, Leslie C Grammer, Kathleen E Harris, Atsushi Kato, Peter H Hwang, Robert C Kern, Leonore A Herzenberg, Robert P Schleimer, Bruce K Tan
BACKGROUND: Immunoglobulin D (IgD) is an enigmatic antibody isotype best known when co-expressed with IgM on naïve B cells. However, elevated soluble IgD (sIgD) and increased IgD(+)IgM(-) B cell populations have been described in the human upper respiratory mucosa. OBJECTIVE: We assessed whether levels of sIgD and IgD(+) B cells are altered in nasal tissue from patients with chronic rhinosinusitis (CRS). We further characterized IgD(+) B cell populations and explored clinical and local inflammatory factors associated with tissue sIgD levels...
June 15, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28622030/age-of-initiation-and-internet-gaming-disorder-the-role-of-self-esteem
#17
Charlotte L Beard, Amie L Haas, Robert E Wickham, Vasileios Stavropoulos
The link between early initiation and problematic use has been observed for substance use disorders; however, this link has not been as clearly established for Internet gaming disorder (IGD). Available studies indicate that individuals who initiate Internet use at younger ages exhibit an increased risk for general Internet addiction. Prior research also suggests unique cognitive processes in online gaming, such that an individual's overall sense of self-worth can become contingent upon self-esteem derived from the gaming environment...
June 2017: Cyberpsychology, Behavior and Social Networking
https://www.readbyqxmd.com/read/28621910/allospecific-memory-b-cell-responses-are-dependent-on-autophagy
#18
M Fribourg, J Ni, F Nina Papavasiliou, Z Yue, P S Heeger, J S Leventhal
Long-lived, donor-reactive memory B cells (Bmems) can produce alloantibodies that mediate transplant injury. Autophagy, an intrinsic mechanism of cell organelle/component recycling, is required for Bmem survival in infectious and model antigen systems, but whether autophagy affects alloreactive Bmem is unknown. We studied mice with an inducible yellow fluorescent protein (YFP) reporter expressed under the activation-induced cytidine deaminase (AID) promoter active in B cells undergoing germinal center reactions...
June 16, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28605137/peripheral-immunophenotyping-identifies-three-subgroups-based-on-t-cell-heterogeneity-in-lupus-patients
#19
Satoshi Kubo, Shingo Nakayamada, Maiko Yoshikawa, Yusuke Miyazaki, Kei Sakata, Kazuhisa Nakano, Kentaro Hanami, Shigeru Iwata, Ippei Miyagawa, Kazuyoshi Saito, Yoshiya Tanaka
OBJECTIVE: To elucidate the diversity of systemic lupus erythematosus (SLE), we stratified active SLE patients based on immunophenotyping. METHODS: Peripheral blood mononuclear cells were obtained from 143 SLE patients and 49 healthy individuals. Circulating B, T and dendritic cells were defined based on flow cytometric analysis for human immune system termed "the Human Immunology Project". Based on these results, the immunophenotype was visualized by principal component analysis and SLE patients classified into subgroups by cluster analysis...
June 12, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28603204/a-6-year-old-girl-diagnosed-with-mevalonate-kinase-deficiency-who-had-hydrops-fetalis-and-neonatal-onset-cholestasis
#20
Yuriko Yamashita, Shinsuke Matsumoto, Ryugo Hiramoto, Isao Komori, Takayuki Tanaka, Ryuta Nishikomori, Toshio Heike, Shuichiro Umetsu, Ayano Inui
  We experienced a 6-year-old girl diagnosed with mevalonate kinase deficiency (MKD) who had cholestasis, anemia, and elevated inflammatory markers in neonatal period. She was admitted to our hospital because of fever and elevated inflammatory markers at 5 years 11months of age. Without using antibiotics, the fever and the inflammatory markers were spontaneously resolved. MKD was suspected from elevated serum IgD level and the recurrent febrile attacks. The genetic test revealed heterozygous mutation of p...
2017: Nihon Rinshō Men'eki Gakkai Kaishi, Japanese Journal of Clinical Immunology
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