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https://www.readbyqxmd.com/read/29472919/in-the-absence-of-central-pre-b-cell-receptor-selection-peripheral-selection-attempts-to-optimize-the-antibody-repertoire-by-enriching-for-cdr-h3-y101
#1
Mohamed Khass, Tessa Blackburn, Ada Elgavish, Peter D Burrows, Harry W Schroeder
Sequential developmental checkpoints are used to "optimize" the B cell antigen receptor repertoire by minimizing production of autoreactive or useless immunoglobulins and enriching for potentially protective antibodies. The first and apparently most impactful checkpoint requires μHC to form a functional pre-B cell receptor (preBCR) by associating with surrogate light chain, which is composed of VpreB and λ5. Absence of any of the preBCR components causes a block in B cell development that is characterized by severe immature B cell lymphopenia...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29472590/elevated-serum-interleukin-34-level-in-patients-with-systemic-lupus-erythematosus-is-associated-with-disease-activity
#2
Huan Huan Xie, Hui Shen, Li Zhang, Mei Ying Cui, Li Ping Xia, Jing Lu
We measured the interleukin-34 (IL-34) level in sera from patients with systemic lupus erythematosus (SLE) and discoid lupus erythematosus (DLE) using an enzyme-linked immunosorbent assay (ELISA). Blood tests, including assays to determine C-reactive protein (CRP), complement (C) 3, C4, immunoglobulin (Ig) A, IgG, IgM, anti-double-stranded DNA antibody (Anti-dsDNA Ab) and hemoglobin (Hb) levels and white blood cell (WBC) and platelet (PLT) counts, were performed using standard methods. Lupus nephritis (LN) was diagnosed according to the American College of Rheumatology (ACR) renal criteria...
February 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29472568/lack-of-galectin-3-modifies-differentially-notch-ligands-in-bone-marrow-and-spleen-stromal-cells-interfering-with-b-cell-differentiation
#3
Felipe Leite de Oliveira, Sofia Nascimento Dos Santos, Lauremilia Ricon, Thayse Pinheiro da Costa, Jonathas Xavier Pereira, Camila Brand, Marise Lopes Fermino, Roger Chammas, Emerson Soares Bernardes, Márcia Cury El-Cheikh
Galectin-3 (Gal-3) is a β-galactoside binding protein that controls cell-cell and cell-extracellular matrix interactions. In lymphoid organs, gal-3 inhibits B cell differentiation by mechanisms poorly understood. The B cell development is dependent on tissue organization and stromal cell signaling, including IL-7 and Notch pathways. Here, we investigate possible mechanisms that gal-3 interferes during B lymphocyte differentiation in the bone marrow (BM) and spleen. The BM of gal-3-deficient mice (Lgals3-/- mice) was evidenced by elevated numbers of B220+ CD19+ c-Kit+ IL-7R+ progenitor B cells...
February 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29469761/schnitzler-syndrome-in-a-patient-with-a-family-history-of-monoclonal-gammopathy
#4
Kelly Wilmas, Alexander Aria, Carlos A Torres-Cabala, Huifang Lu, Madeleine Duvic
Schnitzler syndrome is a rare disease characterized by chronic urticaria and a monoclonal gammopathy, most commonly IgM with light chains of the kappa type. There are currently no known risk factorsassociated with development of the disease. We report a case of Schnitzler syndrome in a 48-year-old man with a family history of monoclonal gammopathies. The patient's disease has been well controlled with anakinra therapy. Our case may contribute to a better understanding of the etiology of Schnitzler syndrome as his history could suggest a hereditarypredisposition for the disease...
January 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469699/mycophenolate-mofetil-as-a-successful-therapy-for-idiopathic-granulomatous-mastitis
#5
Fan Di Xia, Amy Ly, Gideon P Smith
Idiopathic granulomatous mastitis (IGM) is a benign chronic inflammatory breast disease of unknown etiology. No consensus exists as to the best therapeutic approach, though treatment choices include antibiotics, drainage, surgical excision, steroids, methotrexate, and observation. Herein we report a case of idiopathic granulomatous mastitis that was refractory to methotrexate and intralesional and systemic steroids but responded well to mycophenolate mofetil 1500mg twice daily. To our knowledge, this is the first report of the effective use of mycophenolate mofetil in idiopathic granulomatous mastitis...
July 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469352/-survey-of-epidemic-status-of-paragonimiasis-in-western-mountainous-areas-in-hubei-province
#6
Dong Xiao-Rong, Zhang Hua-Xun, Cao Mu-Min, Wu Dong-Ni, Xia Jing
OBJECTIVE: To understand the current status of paragonimiasis epidemic in western mountain areas in Hubei Province. METHODS: Four counties (cities) of Western Hubei Province (Xingshan, Enshi, Yunxi, Baokang) were selected as the investigation sites for active surveillance. Crabs were captured and the metacercariae of Paragonimus were detected. Meanwhile, the blood samples were collected from the residents in the surveillance sites and the unique IgG and IgM antibodies against Paragonimus in the sera were detected by ELISA...
July 5, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29469330/-serological-survey-of-toxoplasma-gondii-infection-in-women-with-adverse-pregnancy-outcomes-in-longhua-region-hebei-province
#7
Zhang Li-Hong, Liu Gui-Fen, Liu Dong-Mei
OBJECTIVE: To understand the status of Toxoplasma gondii infection in women with adverse pregnancy outcomes in Longhua region, Hebei Province. METHODS: A total of 393 women with adverse pregnancy outcomes were chosen as respondents in the Longhua County Maternal and Child Health Care Center between January 2013 and June 2016 and were divided into an acute infection group, a previous infection group, and an active infection group according to the test results. Totally 256 women without adverse pregnancy outcomes were selected as a control group...
March 17, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29466521/prolonged-zika-virus-viremia-in-a-patient-with-guillain-barr%C3%A3-syndrome-in-trinidad-and-tobago
#8
Gabriel Gonzalez-Escobar, Anne Marie Valadere, Rosmond Adams, Karen Polson-Edwards, Avery Q J Hinds, Akenath Misir, C James Hospedales
An emerging mosquito-borne flavivirus, Zika virus (ZIKV) is a significant public health concern because of the syndromes associated with the infection. In addition, ZIKV is considered a major problem due to large-scale spread of the disease and the possible clinical complications for the central nervous system, especially Guillain-Barré syndrome (GBS) and microcephaly. Since the introduction of ZIKV in the Caribbean, molecular detection of the viral RNA has been utilized as a more specific and sensitive approach to demonstrating acute infection...
February 19, 2018: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/29466282/sea-buckthorn-pomace-supplementation-in-the-diet-of-growing-pigs-effects-on-fatty-acid-metabolism-hpa-activity-and-immune-status
#9
Dirk Dannenberger, Margret Tuchscherer, Gerd Nürnberg, Marion Schmicke, Ellen Kanitz
There is evidence that sea buckthorn, as a source of n -3 polyunsaturated fatty acids ( n -3 PUFA), possesses health-enhancing properties and may modulate neuroendocrine and immune functions. In the present study, we investigated the effect of sea buckthorn pomace (SBP) supplementation in the diet of growing German Landrace pigs on fatty acids in the blood and hypothalamus, peripheral immune parameters and mRNA expression of corticotropin-releasing hormone (CRH), mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) in the hypothalamus and spleen...
February 21, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29465612/patient-with-2-hematologic-malignancies-presenting-as-neurolymphomatosis
#10
Ahmad Daher, Carlos Kamiya-Matsuoka, Karin Woodman
Peripheral nervous system damage from hematologic malignancies is related to neoplastic cells infiltration of peripheral nerves or to monoclonal antibody production cross-reacting with peripheral nerves' antigens. Neurolymphomatosis (NL), a rare manifestation of hematologic malignancies, occurs when malignant cells invade the peripheral nerves leading to various manifestations. Here, we report a case of NL with 2 hematologic malignancies in a 79-year-old woman presenting with lower extremity pain/weakness. Investigation revealed anemia, IgM kappa monoclonal gammopathy, and elevated anti-MAG titer...
March 2018: Journal of Clinical Neuromuscular Disease
https://www.readbyqxmd.com/read/29465373/anti-alpha-enolase-antibodies-in-beh%C3%A3-et-s-disease-a-marker-of-mucocutaneous-and-articular-disease-activity
#11
Leandro L Prado, Celio R Goncalves, Vilma T Viana, Carla G S Saad, Eloisa Bonfa
OBJECTIVES: To assess IgM anti-alpha-enolase antibodies (AAEA) in systemic Behçet's disease (BD) and its possible association with clinical manifestations and disease activity. METHODS: Ninety-seven consecutively selected BD patients were compared to 36 enteropathic spondyloarthritis (ESpA) [24 Crohn's disease (CD) and 12 ulcerative colitis (UC)] patients and 87 healthy controls. IgM AAEA was detected by immunoblotting. Disease activity was assessed by standardised indexes, Brazilian BD Current Activity Form (BR-BDCAF) for BD and Harvey-Bradshaw Index (HBI) for CD and UC patients...
February 7, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29465360/serum-soluble-interleukin-2-receptor-is-a-useful-biomarker-for-disease-activity-but-not-for-differential-diagnosis-in-igg4-related-disease-and-primary-sj%C3%A3-gren-s-syndrome-adults-from-a-defined-population
#12
Mitsuhiro Akiyama, Takanori Sasaki, Yuko Kaneko, Hidekata Yasuoka, Katsuya Suzuki, Kunihiro Yamaoka, Tsutomu Takeuchi
OBJECTIVES: To identify biomarkers for disease activity in IgG4-related disease (IgG4-RD) and primary Sjögren's syndrome (pSS). METHODS: Forty-three consecutive treatment-naïve patients with IgG4-RD, 62 patients with pSS, and 5 patients with sicca syndrome were enrolled. IgG4-RD and pSS disease activity was assessed based on the IgG4-RD responder index (IgG4-RD RI) and EULAR Sjögren's Syndrome Disease Activity Index (ES- SDAI), respectively. The associations of biomarkers with disease activity were examined...
February 15, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29465353/serum-igg-acpa-igm-rf-immune-complexes-were-detected-in-rheumatoid-arthritis-patients-positive-for-igm-acpa
#13
Akihisa Haraguchi, Hisakata Yamada, Masakazu Kondo, Ken Okazaki, Jun-Ichi Fukushi, Akiko Oyamada, Yasunobu Yoshikai, Yasuharu Nakashima
OBJECTIVES: Since the presence of IgM antibodies is a hallmark of ongoing immune response, we aimed to identify immunologically active rheumatoid arthritis (RA) patients by detecting IgM anti-citrullinated protein antibody (ACPA) levels. METHODS: IgM ACPA levels were determined in the serum of 176 RA patients by enzyme-linked immunosorbent assay, in which parameters of reactivity against citrullinated and non-citrullinated peptides were compared to ensure the specificity...
February 14, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29462748/dietary-administration-effects-of-fenugreek-seeds-on-skin-mucosal-antioxidant-and-immunity-status-of-gilthead-seabream-sparus-aurata-l
#14
F A Guardiola, A Bahi, A M Jiménez-Monreal, M Martínez-Tomé, M A Murcia, M A Esteban
Improving fish defense through the preventive administration of immunostimulants has an important role in controlling the outbreak of the disease in aquaculture. As a continuity of our previous studies, this paper describes the effects of dietary fenugreek (Trigonella foenum graecum) seeds on the skin mucosal antioxidant status and immune response of gilthead seabream (Sparus aurata L.). Fish were fed with four experimental diets: one a basal diet (control) and three diets with powdered fenugreek seeds incorporated in the fish feed at 1%, 5%, and 10%...
February 17, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29462689/a-hydroxyl-peg-version-of-pegylated-liposomes-and-its-impact-on-anti-peg-igm-induction-and-on-the-accelerated-clearance-of-pegylated-liposomes
#15
Taro Shimizu, Amr S Abu Lila, Risako Fujita, Mizuki Awata, Munehira Kawanishi, Yosuke Hashimoto, Keiichiro Okuhira, Yu Ishima, Tatsuhiro Ishida
Surface decoration of liposomes with polyethylene glycol (PEG), PEGylation, is recognized as a method to bestow liposomes with a prolonged circulation time following intravenous administration. However, many reports have emphasized that a first dose of PEGylated liposomes (PL) elicits an anti-PEG IgM antibody response that can trigger a rapid systemic clearance of a second dose of PL via a phenomenon that is referred to as "accelerated blood clearance (ABC)." Such a phenomenon is usually observed with PL that has been modified with methoxy-PEG...
February 17, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29462595/simultaneous-detection-of-mycoplasma-pneumoniae-igg-and-igm-using-dual-label-time-resolved-fluoroimmunoassay
#16
Yi Zhang, Xue Yang, Jun Qian, Xiaohong Gu, Jue Zhang, Jie Liu, Zhigang Hu
Anti-Mycoplasma pneumoniae (MP) IgM and IgG are useful serological markers for detection of MP infection. In this study, a simultaneous quantification of MP IgM and IgG was performed by time-resolved fluoroimmunoassay (TRFIA). The europium-labeled anti-human IgM and samarium-labeled anti-human IgG were used as tracers, and MP IgM and IgG were recognized in serum samples. After dissociating europium and samarium ions from the immune complex, their fluorescence intensity was recorded and used to calculate the concentrations...
February 17, 2018: Analytical Biochemistry
https://www.readbyqxmd.com/read/29462421/suppression-of-the-igm-response-by-aryl-hydrocarbon-receptor-activation-in-human-primary-b-cells-involves-impairment-of-immunoglobulin-secretory-processes
#17
Jiajun Zhou, Joseph Henriquez, Robert Crawford, Norbert Kaminski
Aryl hydrocarbon receptor (AHR) activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is well established at suppressing humoral immunity. Previous studies in mouse B cells revealed that decreased IgM production was due to a significant suppression in the mRNA levels of the immunoglobulin M components (IgH, IgJ and Igκ chains) and subsequent decrease in IgM synthesis. By contrast, the current study shows that activation of AHR in human B cells also results in a significant suppression of the number of IgM secreting cells, but this is not due to a decrease in the transcription or translation of IgH, IgJ and Igκ chains...
February 16, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29462146/prospective-evaluation-of-accuracy-and-clinical-utility-of-the-dual-path-platform-dpp-assay-for-the-point-of-care-diagnosis-of-leptospirosis-in-hospitalized-patients
#18
Scott A Nabity, José E Hagan, Guilherme Araújo, Alcinéia O Damião, Jaqueline S Cruz, Nivison Nery, Elsio A Wunder, Mitermayer G Reis, Albert I Ko, Guilherme S Ribeiro
Early detection of leptospirosis with field-ready diagnostics may improve clinical management and mitigate outbreaks. We previously validated the point-of-care Dual Path Platform (DPP) for leptospirosis with sera in the laboratory. This prospective study compares the diagnostic accuracy and clinical utility of the DPP using finger stick blood (FSB) against the serum DPP, venous whole blood (VWB) DPP, IgM-ELISA, and clinical impression. We sequentially enrolled 98 patients hospitalized for acute febrile illnesses, of which we confirmed 32 by leptospirosis reference tests...
February 20, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29460894/-the-clinical-and-morphological-characteristics-of-c1q-glomerulopathy
#19
V A Varshavsky, A N Grishina, N V Chebotareva, E I Gudkova
C1q glomerulopathy is a rare variety of chronic glomerulonephritis manifested as C1q deposition revealed by immunofluorescence microscopy. The pathogenesis and etiology of the disease have not been studied. The paper deals with the results of clinical, morphological, immunofluorescence, and electron microscopic examinations in 13 patients with C1q glomerulopathy. Light microscopy more commonly revealed membranous nephropathy, mesangioproliferative glomerulonephritis, and nephrosclerosis. Immunofluorescence microscopy detected a C1q fraction in association with other deposits, more frequently IgM and IgG ones...
2018: Arkhiv Patologii
https://www.readbyqxmd.com/read/29460860/aetiology-of-acute-encephalitis-syndrome-in-uttar-pradesh-india-from-2014-to-2016
#20
Parul Jain, Shantanu Prakash, Danish N Khan, Ravindra Kumar Garg, Rashmi Kumar, Amit Bhagat, V Ramakrishna, Amita Jain
Background & objectives: It is imperative to know the aetiology of acute encephalitis syndrome (AES) for patient management and policy making. The present study was carried out to determine the prevalence of common aetiological agents of AES in Uttar Pradesh (UP) state of India. Methods: Serum and/or CSF samples were collected from AES patients admitted at Gandhi Memorial and Associated Hospital, King George's Medical University, Lucknow, a tertiary care centre, UP during 2014-16...
October 2017: Journal of Vector Borne Diseases
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