keyword
MENU ▼
Read by QxMD icon Read
search

Neuropeptide

keyword
https://www.readbyqxmd.com/read/28920040/parasympathetic-cholinergic-and-neuropeptide-mechanisms-of-migraine
#1
REVIEW
Nikita Mikhailov, Oleg V Mamontov, Alexei A Kamshilin, Rashid Giniatullin
CONTEXT: Migraine mechanisms remain largely uncovered for various reasons including a very high complexity of the neurophysiological mechanisms implicated in this disorder and a plethora of endogenous biologically active compounds involved in the pathological process. The functional role of parasympathetic innervation of meninges and cholinergic mechanisms of migraine are among little explored issues despite multiple evidence indirectly indicating the role of acetylcholine (ACh) and its analogues in migraine and other types of headache...
February 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/28917449/highly-potent-antiobesity-effect-of-a-short-length-peptide-yy-analog-in-mice
#2
Naoki Nishizawa, Ayumu Niida, Yusuke Adachi, Yoko Kanematsu-Yamaki, Yasushi Masuda, Satoshi Kumano, Kotaro Yokoyama, Yoko Noguchi, Tomoko Asakawa, Hideki Hirabayashi, Nobuyuki Amano, Shiro Takekawa, Tetsuya Ohtaki, Taiji Asami
Continuous administration of a 14-amino acid peptide YY (PYY) analog, Ac-[d-Pro(24),Pya(4)(26),Cha(27,36),Aib(28,31),Lys(30)]PYY(23-36) (4), which has a high binding affinity and agonist activity for the neuropeptide Y2 receptor (Y2R), has previously shown an antiobesity effect in a 2-week diet-induced obesity (DIO) study in mice. However, there remained a possibility to obtain more potent analogs by further improving its pharmacokinetic profile. A combination of the N-terminal 4-imidazolecarbonyl moiety and three amino acid substitutions, trans-4-hydroxy-d-proline (d-Hyp)(24), isovaline (Iva)(25), and γ-methylleucine (γMeLeu)(28), not only improved the binding affinity of the peptide for Y2R but also increased its anorectic activity in lean mice...
September 1, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28917185/ghrelin-and-hypothalamic-npy-agrp-expression-in-mice-are-affected-by-chronic-early-life-stress-exposure-in-a-sex-specific-manner
#3
K Y Yam, S R Ruigrok, I Ziko, S N De Luca, P J Lucassen, S J Spencer, A Korosi
Early-life stress (ES) is a risk factor for metabolic disorders (e.g. obesity) with a notoriously higher prevalence in women compared to men. However, mechanisms underlying these effects remain elusive. The development of the hypothalamic feeding and metabolic regulatory circuits occurs mostly in the early sensitive postnatal phase in rodents and is tightly regulated by the metabolic hormones leptin and ghrelin. We have previously demonstrated that chronic ES reduces circulating leptin and alters adipose tissue metabolism early and later in life similarly in both sexes...
September 7, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28916209/towards-new-strategies-to-manage-livestock-reproduction-using-kisspeptin-analogs
#4
M Beltramo, C Decourt
The discovery of the hypothalamic neuropeptide kisspeptin and its receptor (KISS1R) have dramatically improved our knowledge about the central mechanisms controlling reproduction. Kisspeptin neurons could be considered the hub where internal and external information controlling reproduction converge. The information is here elaborated and the command dispatched to GnRH neurons, the final output of the brain system controlling reproduction. Several studies have shown that in mammals administration of kisspeptin could finely modulate many aspects of reproduction from puberty to ovulation...
September 12, 2017: Theriogenology
https://www.readbyqxmd.com/read/28916197/invertebrate-neuropeptides-xvi
#5
EDITORIAL
Ronald J Nachman, Young Joon Kim
No abstract text is available yet for this article.
September 12, 2017: Peptides
https://www.readbyqxmd.com/read/28916169/the-large-and-small-spen-family-proteins-stimulate-axon-outgrowth-during-neurosecretory-cell-remodeling-in-drosophila
#6
Tingting Gu, Tao Zhao, Uday Kohli, Randall S Hewes
Split ends (SPEN) is the founding member of a well conserved family of nuclear proteins with critical functions in transcriptional regulation and the post-transcriptional processing and nuclear export of transcripts. In animals, the SPEN proteins fall into two size classes that perform either complementary or antagonistic functions in different cellular contexts. Here, we show that the two Drosophila representatives of this family, SPEN and Spenito (NITO), regulate metamorphic remodeling of the CCAP/bursicon neurosecretory cells...
September 12, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28915981/transcutaneous-electrical-acupoint-stimulation-improves-the-outcomes-of-in-vitro-fertilization-a-prospective-randomized-and-controlled-study
#7
Fan Qu, Fang-Fang Wang, Yan Wu, Jue Zhou, Nicola Robinson, Paul J Hardiman, Jie-Xue Pan, Yi-Jing He, Yu-Hang Zhu, Han-Zhi Wang, Xiao-Qun Ye, Ke-Lin He, Long Cui, Hong-Li Zhao, Ying-Hui Ye
OBJECTIVES: To explore whether transcutaneous electrical acupoint stimulation (TEAS) can improve the outcomes of in vitro fertilization (IVF). DESIGN: A prospective, randomized, and controlled study. SETTING: IVF center in a university hospital. PARTICIPANTS: Four hundred and eighty-one infertile patients with bilateral tubal blockage who were referred for IVF. Patients were randomized into four groups. INTERVENTION: TEAS was administered for 30min, respectively, at 24h before TVOR and two hours before ET...
September 2017: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/28915382/oxytocin-modulates-human-communication-by-enhancing-cognitive-exploration
#8
Miriam de Boer, Idil Kokal, Mark Blokpoel, Rui Liu, Arjen Stolk, Karin Roelofs, Iris van Rooij, Ivan Toni
Oxytocin is a neuropeptide known to influence how humans share material resources. Here we explore whether oxytocin influences how we share knowledge. We focus on two distinguishing features of human communication, namely the ability to select communicative signals that disambiguate the many-to-many mappings that exist between a signal's form and meaning, and adjustments of those signals to the presumed cognitive characteristics of the addressee ("audience design"). Fifty-five males participated in a randomized, double-blind, placebo controlled experiment involving the intranasal administration of oxytocin...
September 8, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28914594/salivary-neuropeptides-stress-and-periodontitis
#9
Hady Haririan, Oleh Andrukhov, Michael Böttcher, Eleonore Pablik, Gernot Wimmer, Andreas Moritz, Xiaohui Rausch-Fan
BACKGROUND: Scientific evidence for psychological stress as a risk factor for periodontitis is fragmentary relying mostly on either questionnaire-based or biomarker studies. The aim of this study was to investigate Brain Derived Neurotrophic Factor, Substance P, Vasoactive Intestinal Peptide (VIP), Neuropeptide Y (NPY), Calcitonin Gene Related Peptide and Adrenomedullin as well as cortisol in saliva and serum in periodontal health and disease combined with different aspects of stress and possible associations with clinical parameters...
September 15, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28914170/the-investigation-of-the-effects-of-topiramate-on-the-hypothalamic-levels-of-fat-mass-obesity-associated-protein-and-neuropeptide-y-in-obese-female-rats
#10
Işınsu Alkan, Berrin Zuhal Altunkaynak, Gamze Altun, Erkan Erener
OBJECTIVE: The aim of the present study is to investigate the effects of topiramate on the fat mass/obesity-associated protein (FTO) and on the neuropeptide Y (NPY) level in the hypothalamus depending on the recently increased prevalence of obesity. METHOD: In this study, twenty-four female rats were divided into four equal groups: Non-obese control, obese control, non-obese topiramate, and obese topiramate. Obese groups were fed with a 40% high-fat diet. At the end of the 9th week, the drug treatment started and the subjects were treated with topiramate once a day for 6 weeks...
September 15, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28913358/central-modulation-of-neuroinflammation-by-neuropeptides-and-energy-sensing-hormones-during-obesity
#11
REVIEW
Roger Maldonado-Ruiz, Lizeth Fuentes-Mera, Alberto Camacho
Central nervous system (CNS) senses energy homeostasis by integrating both peripheral and autonomic signals and responding to them by neurotransmitters and neuropeptides release. Although it is previously considered an immunologically privileged organ, we now know that this is not so. Cells belonging to the immune system, such as B and T lymphocytes, can be recruited into the CNS to face damage or infection, in addition to possessing resident immunological cells, called microglia. In this way, positive energy balance during obesity promotes an inflammatory state in the CNS...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28912554/oxytocin-stimulates-hippocampal-neurogenesis-via-oxytocin-receptor-expressed-in-ca3-pyramidal-neurons
#12
Yu-Ting Lin, Chien-Chung Chen, Chiung-Chun Huang, Katsuhiko Nishimori, Kuei-Sen Hsu
In addition to the regulation of social and emotional behaviors, the hypothalamic neuropeptide oxytocin has been shown to stimulate neurogenesis in adult dentate gyrus; however, the mechanisms underlying the action of oxytocin are still unclear. Taking advantage of the conditional knockout mouse model, we show here that endogenous oxytocin signaling functions in a non-cell autonomous manner to regulate survival and maturation of newly generated dentate granule cells in adult mouse hippocampus via oxytocin receptors expressed in CA3 pyramidal neurons...
September 14, 2017: Nature Communications
https://www.readbyqxmd.com/read/28912494/oxytocin-receptor-polymorphisms-are-differentially-associated-with-social-abilities-across-neurodevelopmental-disorders
#13
Danielle A Baribeau, Annie Dupuis, Tara A Paton, Stephen W Scherer, Russell J Schachar, Paul D Arnold, Peter Szatmari, Rob Nicolson, Stelios Georgiades, Jennifer Crosbie, Jessica Brian, Alana Iaboni, Jason Lerch, Evdokia Anagnostou
Oxytocin is a pituitary neuropeptide that affects social behaviour. Single nucleotide polymorphisms (SNPs) in the oxytocin receptor gene (OXTR) have been shown to explain some variability in social abilities in control populations. Whether these variants similarly contribute to the severity of social deficits experienced by children with neurodevelopmental disorders is unclear. Social abilities were assessed in a group of children with autism spectrum disorder (ASD, n = 341) or attention deficit hyperactivity disorder (ADHD, n = 276) using two established social measures...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28910447/orexin-a-suppresses-signal-transmission-to-dopaminergic-amacrine-cells-from-outer-and-inner-retinal-photoreceptors
#14
Sheng-Nan Qiao, Wei Zhou, Lei-Lei Liu, Dao-Qi Zhang, Yong-Mei Zhong
Purpose: The neuropeptides orexin-A and orexin-B are widely expressed in the vertebrate retina; however, their role in visual function is unclear. This study investigates whether and how orexins modulate signal transmission to dopaminergic amacrine cells (DACs) from both outer retinal photoreceptors (rods and cones) and inner retinal photoreceptors (melanopsin-expressing intrinsically photosensitive retinal ganglion cells [ipRGCs]). Methods: A whole-cell voltage-clamp technique was used to record light-induced responses from genetically labeled DACs in flat-mount mouse retinas...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28904207/two-kinesins-drive-anterograde-neuropeptide-transport
#15
Angeline Lim, Andreas Rechtsteiner, William M Saxton
Motor-dependent anterograde transport, a process that moves cytoplasmic components from sites of biosynthesis to sites of use within cells, is crucial in neurons with long axons. Evidence has emerged that multiple anterograde kinesins can contribute to some transport processes. To test the multi-kinesin possibility for a single vesicle type, we studied the functional relationships of axonal kinesins to dense core vesicles (DCVs) that were filled with a GFP-tagged neuropeptide in the Drosophila nervous system...
September 13, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28904199/calcitonin-gene-related-peptide-induces-hiv-1-proteasomal-degradation-in-mucosal-langerhans-cells
#16
Morgane Bomsel, Yonatan Ganor
The neuro-immune dialogue between peripheral neurons and Langerhans cells (LCs) within mucosal epithelia protects against incoming pathogens. LCs rapidly internalize human immunodeficiency virus type 1 (HIV-1) upon its sexual transmission and then trans-infect CD4+ T-cells. We recently found that the neuropeptide calcitonin gene-related peptide (CGRP), secreted mucosally from peripheral neurons, inhibits LCs-mediated HIV-1 trans-infection. Herein, we investigated the mechanism of CGRP-induced inhibition, focusing on HIV-1 degradation in LCs and its interplay with trans-infection...
September 13, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28902842/the-neuropeptide-nmu-amplifies-ilc2-driven-allergic-lung-inflammation
#17
Antonia Wallrapp, Samantha J Riesenfeld, Patrick R Burkett, Raja-Elie E Abdulnour, Jackson Nyman, Danielle Dionne, Matan Hofree, Michael S Cuoco, Christopher Rodman, Daneyal Farouq, Brian J Haas, Timothy L Tickle, John J Trombetta, Pankaj Baral, Christoph S N Klose, Tanel Mahlakõiv, David Artis, Orit Rozenblatt-Rosen, Isaac M Chiu, Bruce D Levy, Monika S Kowalczyk, Aviv Regev, Vijay K Kuchroo
Type 2 innate lymphoid cells (ILC2s) both contribute to mucosal homeostasis and initiate pathologic inflammation in allergic asthma. However, the signals that direct ILC2s to promote homeostasis versus inflammation are unclear. To identify such molecular cues, we profiled mouse lung-resident ILCs using single-cell RNA sequencing at steady state and after in vivo stimulation with the alarmin cytokines IL-25 and IL-33. ILC2s were transcriptionally heterogeneous after activation, with subpopulations distinguished by expression of proliferative, homeostatic and effector genes...
September 13, 2017: Nature
https://www.readbyqxmd.com/read/28902709/effect-of-food-deprivation-on-the-hypothalamic-gene-expression-of-the-secretogranin-ii-derived-peptide-em66-in-rat
#18
Fatima Trebak, Isabelle Dubuc, Marie Picot, Abdelilah Alaoui, Jérôme Leprince, Gaëtan Prévost, Youssef Anouar, Rabia Magoul, Nicolas Chartrel
EM66 is a peptide derived from the chromogranin, secretogranin II (SG-II). Recent findings in mice indicate that EM66 is a novel anorexigenic neuropeptide that regulates hypothalamic feeding behavior, at least in part, by activating the POMC neurons of the arcuate nucleus. The present study aimed to investigate the mechanism of action of EM66 in the control of feeding behavior and, more specifically, its potential interactions with the NPY and POMC systems in rat. We analyzed by Q-PCR the gene expression of the EM66 precursor, SG-II, in hypothalamic extracts following 2, 3, or 4 days of food deprivation and compared it with the expression levels of the two major neuropeptidergic systems, that is, POMC and NPY, modulating feeding behavior...
September 11, 2017: Neuroreport
https://www.readbyqxmd.com/read/28901800/changes-in-expression-of-neuropeptides-and-their-receptors-in-the-hypothalamus-and-gastrointestinal-tract-of-calorie-restricted-hens
#19
Ádám Simon, János Oláh, István Komlósi, András Jávor, József Németh, Zoltán Szilvássy, Dóra Reglődi, Andrea Tamás, Levente Czeglédi
The list of orexigenic and anorexigenic peptides, those are known to alter feed intake, is continuously growing. However, most of them are studied in mammalian species. We aimed to investigate plasma level and mRNA expression of the pituitary adenylate cyclase-activating polypeptide (PACAP), gene expression of its receptor (PAC1), furthermore the gene expression of galanin (GAL), neuromedin U (NMU), and its two receptors (NMUR1 and NMUR2) in the hypothalamus, proventriculus, and jejunum of hens exposed to 40% calorie restriction...
September 2017: Acta Biologica Hungarica
https://www.readbyqxmd.com/read/28901728/gaba-type-a-receptor-trafficking-and-the-architecture-of-synaptic-inhibition
#20
REVIEW
Joshua M Lorenz-Guertin, Tija C Jacob
Ubiquitous expression of GABA type A receptors (GABAA R) in the central nervous system establishes their central role in coordinating most aspects of neural function and development. Dysregulation of GABAergic neurotransmission manifests in a number of human health disorders and conditions that in certain cases can be alleviated by drugs targeting these receptors. Precise changes in the quantity or activity of GABAA Rs localized at the cell surface and at GABAergic postsynaptic sites directly impact the strength of inhibition...
September 13, 2017: Developmental Neurobiology
keyword
keyword
19690
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"