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https://www.readbyqxmd.com/read/28198750/relentless-placoid-chorioretinitis-successful-long-term-treatment-with-intravitreal-triamcinolone
#1
Daniel B Roth, Sheila Ballintine, Dimosthenis Mantopoulos, Jonathan Prenner, Howard F Fine
PURPOSE: To report a case of relentless placoid chorioretinitis (ampiginous choroiditis) treated with intravitreal triamcinolone acetonide (IVTA). METHODS: Interventional case report. RESULTS: A 34-year-old pregnant woman with a history of poor visual acuity in her left eye, secondary to an undetermined cause, developed an acute painless central scotoma and blurred vision in the right eye. The examination revealed decreased visual acuity, active inflammatory placoid choroidal lesions in the posterior pole, and mid-periphery with sharp disk margins and normal-appearing vasculature...
February 14, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28191383/minimally-invasive-direct-lateral-interbody-fusion-mis-dlif-proof-of-concept-and-perioperative-results
#2
Hamid Abbasi, Ali Abbasi
BACKGROUND: Minimally invasive direct lateral interbody fusion (MIS-DLIF) is a novel approach for fusions of the lumbar spine. In this proof of concept study, we describe the surgical technique and report our experience and the perioperative outcomes of the first nine patients who underwent this procedure. STUDY DESIGN/SETTING: In this study we establish the safety and efficacy of this approach. MIS-DLIF was performed on 15 spinal levels in nine patients who failed to respond to conservative therapy for the treatment of a re-herniated disk, spondylolisthesis, or other severe disk disease of the lumbar spine...
January 14, 2017: Curēus
https://www.readbyqxmd.com/read/28182054/design-formulation-and-physicochemical-evaluation-of-periodontal-propolis-mucoadhesive-gel
#3
Abolfazl Aslani, Negar Malekpour
BACKGROUND: Periodontitis is a disease of tooth supporting tissues, and Gram-negative Bacteria are the main cause of this. Propolis has antibacterial, anti-inflammatory, and antioxidant effects due to its high polyphenol and flavonoids content. The aim of this study is the formulation of a mucoadhesive gel containing concentrated extract of propolis for treatment of periodontitis. MATERIALS AND METHODS: Formulations containing carbopol 940, sodium carboxymethylcellulose (NaCMC), hydroxypropyl methylcellulose K4M, and propolis extract were prepared...
November 2016: Dental Research Journal
https://www.readbyqxmd.com/read/28149515/bloodstream-infections-and-antimicrobial-sensitivity-patterns-in-a-tertiary-care-hospital-of-india
#4
Nikita Vasudeva, Prem Singh Nirwan, Preeti Shrivastava
BACKGROUND: Invasion of the bloodstream by microorganisms constitutes one of the most serious situations in infectious disease. Microorganisms present in circulating blood whether continuously, intermittently, or transiently are a threat to every organ in the body. Prevalence and antimicrobial susceptibility of microorganisms vary depending upon the geography and the use of antibiotics. METHODS: A cross-sectional study to determine the prevalent organisms causing bloodstream infection was conducted...
October 2016: Therapeutic Advances in Infectious Disease
https://www.readbyqxmd.com/read/28146002/development-of-the-ibd-disk-a-visual-self-administered-tool-for-assessing-disability-in-inflammatory-bowel-diseases
#5
Subrata Ghosh, Edouard Louis, Laurent Beaugerie, Peter Bossuyt, Guillaume Bouguen, Arnaud Bourreille, Marc Ferrante, Denis Franchimont, Karen Frost, Xavier Hebuterne, John K Marshall, Ciara OʼShea, Greg Rosenfeld, Chadwick Williams, Laurent Peyrin-Biroulet
BACKGROUND: The Inflammatory bowel disease (IBD) Disability Index is a validated tool that evaluates functional status; however, it is used mainly in the clinical trial setting. We describe the use of an iterative Delphi consensus process to develop the IBD Disk-a shortened, self-administered adaption of the validated IBD Disability Index-to give immediate visual representation of patient-reported IBD-related disability. METHODS: In the preparatory phase, the IBD CONNECT group (30 health care professionals) ranked IBD Disability Index items in the perceived order of importance...
January 31, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28141749/thickness-of-the-macula-retinal-nerve-fiber-layer-and-ganglion-cell-inner-plexiform-layer-in-the-age-related-macular-degeneration-the-repeatability-study-of-spectral-domain-optical-coherence-tomography
#6
Il-Hwan Shin, Woo-Hyuk Lee, Jong-Joo Lee, Young-Joon Jo, Jung-Yeul Kim
PURPOSE: To determine the repeatability of measuring the thickness of the central macula, retinal nerve fiber layer, and ganglion cell-inner plexiform layer (GC-IPL) using spectral domain optical coherence tomography (Cirrus HD-OCT) in eyes with age-related macular degeneration. METHODS: One hundred and thirty-four eyes were included. The measurement repeatability was assessed by an experienced examiner who performed two consecutive measurements using a 512 × 128 macular cube scan and a 200 × 200 optic disk cube scan...
January 30, 2017: Retina
https://www.readbyqxmd.com/read/28140641/preliminary-evaluation-of-the-effects-of-photobiomodulation-therapy-and-physical-rehabilitation-on-early-postoperative-recovery-of-dogs-undergoing-hemilaminectomy-for-treatment-of-thoracolumbar-intervertebral-disk-disease
#7
Michael Bennaim, Mathilde Porato, Astrid Jarleton, Martin Hamon, James D Carroll, Kris Gommeren, Marc Balligand
OBJECTIVE To evaluate the effects of postoperative photobiomodulation therapy and physical rehabilitation on early recovery variables for dogs after hemilaminectomy for treatment of intervertebral disk disease. ANIMALS 32 nonambulatory client-owned dogs. PROCEDURES Dogs received standard postoperative care with photobiomodulation therapy (n = 11), physical rehabilitation with sham photobiomodulation treatment (11), or sham photobiomodulation treatment only (10) after surgery. Neurologic status at admission, diagnostic and surgical variables, duration of postoperative IV analgesic administration, and recovery grades (over 10 days after surgery) were assessed...
February 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28137565/integrated-and-quantitative-proteomics-of-human-tumors
#8
Y Yakkioui, Y Temel, E Chevet, L Negroni
Quantitative proteomics represents a powerful approach for the comprehensive analysis of proteins expressed under defined conditions. These properties have been used to investigate the proteome of disease states, including cancer. It has become a major subject of studies to apply proteomics for biomarker and therapeutic target identification. In the last decades, technical advances in mass spectrometry have increased the capacity of protein identification and quantification. Moreover, the analysis of posttranslational modification (PTM), especially phosphorylation, has allowed large-scale identification of biological mechanisms...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28125786/ct-abnormalities-in-the-sacroiliac-joints-of-patients-with-diffuse-idiopathic-skeletal-hyperostosis
#9
Naama Leibushor, Einat Slonimsky, Dvora Aharoni, Merav Lidar, Iris Eshed
OBJECTIVE: The purpose of this study is to characterize sacroiliac joints (SIJs) findings at CT of patients with diffuse idiopathic skeletal hyperostosis (DISH), a condition characterized (using the Resnick classification criteria) by ossification of at least four contiguous vertebrae in the thoracic spine and preserved disk space, but without radiographic evidence of intraarticular SIJ abnormalities. MATERIALS AND METHODS: Pelvic CT examinations of 104 patients with DISH (fulfilling the Resnick criteria on spinal CT) and 106 age- and sex-matched control subjects whose entire spine lacked CT evidence of DISH (total, 149 men and 61 women; mean [± SD] age, 72...
January 26, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28107234/comparison-between-acrylic-cage-and-polyetheretherketone-peek-cage-in-single-level-anterior-cervical-discectomy-and-fusion-a-randomized-clinical-trial
#10
Majid R Farrokhi, Zahra Nikoo, Mehrnaz Gholami, Khadijeh Hosseini
STUDY DESIGN: Prospective, single-blind randomized-controlled clinical study. OBJECTIVE: To compare polyetheretherketone (PEEK) cage with a novel Acrylic cage to find out which fusion cage yielded better clinical outcomes following single-level anterior cervical discectomy and fusion (ACDF). SUMMARY OF BACKGROUND DATA: ACDF is considered a standard neurosurgical treatment for degenerative diseases of cervical intervertebral disks. There are many options, including bone grafts, bone cement, and spacers made of titanium, carbon fiber, and synthetic materials, used to restore physiological disk height and enhance spinal fusion, but the ideal device, which would provide immediate structural support and subsequent osteointegration and stability, has not been identified yet...
February 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28106379/sustainable-release-of-vancomycin-from-silk-fibroin-nanoparticles-for-treating-severe-bone-infection-in-rat-tibia-osteomyelitis-model
#11
Negar Hassani Besheli, Fatemeh Mottaghitalab, Masoud Eslami, Mahdi Gholami, Subhas C Kundu, David L Kaplan, Mehdi Farokhi
The successful treatment of bone infections is a major challenge in the field of orthopedics. There are some common methods for treating bone infections, including systemic antibiotic administration, local nondegradable drug vehicles, and surgical debridement, and each of these approaches has advantages and disadvantages. In the present study, the antibiotic vancomycin (VANCO) was loaded in silk fibroin nanoparticles (SFNPs) and the complexes were then entrapped in silk scaffolds to form sustained drug delivery systems...
February 6, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28102477/potential-new-mechanisms-of-pro-arrhythmia-in-arrhythmogenic-cardiomyopathy-focus-on-calcium-sensitive-pathways
#12
REVIEW
C J M van Opbergen, M Delmar, T A B van Veen
Arrhythmogenic cardiomyopathy, or its most well-known subform arrhythmogenic right ventricular cardiomyopathy (ARVC), is a cardiac disease mainly characterised by a gradual replacement of the myocardial mass by fibrous and fatty tissue, leading to dilatation of the ventricular wall, arrhythmias and progression towards heart failure. ARVC is commonly regarded as a disease of the intercalated disk in which mutations in desmosomal proteins are an important causative factor. Interestingly, the Dutch founder mutation PLN R14Del has been identified to play an additional, and major, role in ARVC patients within the Netherlands...
January 19, 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/28099107/case-238-spontaneous-pneumothorax-secondary-to-intrapulmonary-necrobiotic-rheumatoid-nodule
#13
Ammar A Chaudhry, Maryam Gul, Abbas A Chaudhry, William Moore
History A 54-year-old white woman with a history of rheumatoid arthritis who was taking glucocorticoids and methotrexate presented to the emergency department in December with worsening shortness of breath and chest heaviness for 1 week. She reported additional symptoms of weakness, headache, and arthralgia primarily involving her bilateral hands, wrist, ankles, and feet. She denied experiencing fevers, syncope or presyncope, focal neurologic deficits, chest pain, nausea, vomiting, unintentional weight loss, or recent trauma...
February 2017: Radiology
https://www.readbyqxmd.com/read/28072493/patterns-of-infections-aetiological-agents-and-antimicrobial-resistance-at-a-tertiary-care-hospital-in-northern-tanzania
#14
Happiness Houka Kumburu, Tolbert Sonda, Blandina Theophil Mmbaga, Michael Alifrangis, Ole Lund, Gibson Kibiki, Frank M Aarestrup
OBJECTIVE: To determine the causative agents of infections and their antimicrobial susceptibility at a tertiary care hospital in Moshi, Tanzania, to guide optimal treatment. METHODS: A total of 590 specimens (stool (56), sputum (122), blood (126) and wound swabs (286)) were collected from 575 patients admitted in the medical and surgical departments. The bacterial species were determined by conventional methods, and disc diffusion was used to determine the antimicrobial susceptibility pattern of the bacterial isolates...
January 10, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28064562/new-interpretive-criteria-for-danofloxacin-antibacterial-susceptibility-testing-against-mannheimia-haemolytica-and-pasteurella-multocida-associated-with-bovine-respiratory-disease
#15
Michael T Sweeney, Mark G Papich, Jeffrey L Watts
Danofloxacin is a fluoroquinolone antibacterial agent approved for use in veterinary medicine to treat and control bovine respiratory disease caused by Mannheimia haemolytica or Pasteurella multocida. Susceptible minimal inhibitory concentration (MIC) breakpoint (≤0.25 µg/mL) and disk diffusion interpretive criteria (≥22 mm) values for danofloxacin against M. haemolytica and P. multocida were first approved by the Clinical and Laboratory Standards Institute (CLSI) in 2003. However, intermediate and resistant breakpoint values were not established because only susceptible wild-type populations were evident at the time of breakpoint approvals...
January 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28059946/comparative-study-of-the-difference-of-perioperative-complication-and-radiologic-results-mis-dlif-minimally-invasive-direct-lateral-lumbar-interbody-fusion-versus-mis-olif-minimally-invasive-oblique-lateral-lumbar-interbody-fusion
#16
Jie Jin, Kyeong-Sik Ryu, Jung-Woo Hur, Ji-Hoon Seong, Jin-Sung Kim, Hyun-Jin Cho
STUDY DESIGN: Retrospective observatory analysis. OBJECTIVE: The purpose of this study was to compare the incidence of perioperative complication, difference of cage location, and sagittal alignment between minimally invasive oblique lateral lumbar interbody fusion (MIS-OLIF) and MIS-direct lateral lumbar interbody fusion (DLIF) in the cases of single-level surgery at L4-L5. SUMMARY OF BACKGROUND DATA: MIS-DLIF using tubular retractor has been used for the treatment of lumbar degenerative diseases; however, blunt transpsoas dissection poses a risk of injury to the lumbar plexus...
January 4, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28045017/protective-effects-of-intercalated-disk-protein-afadin-on-chronic-pressure-overload-induced-myocardial-damage
#17
Dimitar P Zankov, Akio Shimizu, Miki Tanaka-Okamoto, Jun Miyoshi, Hisakazu Ogita
Adhesive intercellular connections at cardiomyocyte intercalated disks (IDs) support contractile force and maintain structural integrity of the heart muscle. Disturbances of the proteins at IDs deteriorate cardiac function and morphology. An adaptor protein afadin, one of the components of adherens junctions, is expressed ubiquitously including IDs. At present, the precise role of afadin in cardiac physiology or disease is unknown. To explore this, we generated conditional knockout (cKO) mice with cardiomyocyte-targeted deletion of afadin...
January 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28039377/detection-of-serotype-distribution-and-drug-resistance-of-streptococcus-pneumoniae-isolated-from-pediatric-patients
#18
Junrong Wang, Fenqin Liu, Peiran Ao, Xianneng Li, Haixiao Zheng, Di Wu, Nina Zhang, Junping Yu, Junhui Yuan, Xiuying Wu
OBJECTIVE: To analyze the serotype distribution and drug resistance of Streptococcus pneumoniae isolated from pediatric patients in a Chinese hospital. METHODS: From October 2011 to May 2014, we collected 284 isolates (including 217 noninvasive and 67 invasive strains). We tested the antimicrobial susceptibility of these specimens using the Epsilomer test and disk diffusion method, and the expression of macrolide resistant genes ermB and mefA by polymerase chain reaction...
December 29, 2016: Laboratory Medicine
https://www.readbyqxmd.com/read/28025450/application-of-fiber-tractography-and-diffusion-tensor-imaging-to-evaluate-spinal-cord-diseases-in-dogs
#19
Yuko Konishi, Hiroyuki Satoh, Yasuyoshi Kuroiwa, Mizuki Kusaka, Atsushi Yamashita, Yujiro Asada, Taketoshi Asanuma
Fiber tractography is a technique capable of depicting the three-dimensional structure and connectivity of nerve fibers using serial magnetic resonance diffusion tensor imaging (DTI). To establish fiber tractography and DTI methods in veterinary clinical medicine, we evaluated fiber tractography and DTI parameters: apparent diffusion coefficient (ADC) values and fractional anisotropy (FA) values, in various spinal cord diseases. Spinal cord DTI was examined in 28 dogs with spinal cord diseases. The ADC and FA values were measured at lesion sites and cranial normal sites on spinal cords, and both values of lesion sites were compared with normal sites...
December 23, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28005616/five-year-reoperation-rates-of-2-level-lumbar-total-disk-replacement-versus-fusion-results-of-a-prospective-randomized-clinical-trial
#20
Kris Radcliff, Jeffrey Spivak, Bruce Darden, Michael Janssen, Thierry Bernard, Jack Zigler
STUDY DESIGN: Long-term analysis of prospective randomized clinical trial data. SUMMARY OF BACKGROUND DATA: Lumbar total disk replacement (TDR) has been found to have equivalent or superior clinical outcomes compared with fusion and decreased radiographic incidence of adjacent level degeneration in single-level cases. OBJECTIVE: The purpose of this particular analysis was to determine the incidence and risk factors for secondary surgery in patients treated with TDR or circumferential fusion at 2 contiguous levels of the lumbar spine...
December 21, 2016: Clinical Spine Surgery
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