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https://www.readbyqxmd.com/read/29925105/developmental-changes-in-isometric-strength-longitudinal-study-in-adolescent-soccer-players
#1
Joao P Duarte, João Valente-Dos-Santos, Manuel J Coelho-E-Silva, R M Malina, Dieter Deprez, Renaat Philippaerts, Matthieu Lenoir, Roel Vaeyens
This study aimed to examine longitudinal changes in isometric strength of the knee extensors (ImKE) and knee flexors (ImKF) at 30° and 60°. The sample was composed of 67 players aged 11.0-13.9 years at baseline over five years. Stature, body mass, skinfolds, and isometric strength (ImKE30°, ImKF30°, ImKE60° and ImKF60°) were measured. Fat mass and fat-free mass (FFM) were derived from skinfolds. Skeletal age was obtained using TW2 RUS. Multilevel random effects regression analyses extracted developmental polynomial models...
June 20, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29925104/right-tkr-patients-treated-with-enhanced-pain-and-rehabilitation-protocols-can-drive-at-2-weeks
#2
David F Dalury, Danielle M Chapman
An important milestone in the recovery following total knee replacement (TKR) is the ability to return to driving. With advances in pain control and the widespread introduction of rapid rehab programs, we hypothesized that the ability to drive would also return sooner than had been traditionally observed. In our group of consecutive right TKR patients, using a driving simulator, we showed that at the 2-week mark, 36 of the 40 patients tested had returned to their preoperative driving capabilities and the other 4 had reached baseline at 3 weeks...
June 20, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29925084/evaluation-of-stop-smoking-in-its-tracks-an-intensive-smoking-cessation-program-for-pregnant-aboriginal-women-incorporating-contingency-based-financial-rewards
#3
Megan E Passey, Janelle M Stirling
BACKGROUND: Smoking during pregnancy is three times as common among Aboriginal women as non-Aboriginal women, with consequent higher rates of adverse health outcomes. Effective interventions to support Aboriginal women to quit smoking have not yet been identified. OBJECTIVES: To assess the feasibility and acceptability of implementing a culturally tailored, intensive smoking cessation program, including contingency-based financial rewards (CBFR), for pregnant Aboriginal women...
June 14, 2018: Public Health Research & Practice
https://www.readbyqxmd.com/read/29925083/adapting-to-sydney-s-local-government-boundaries-changes-a-population-health-perspective
#4
Hassan Assareh, Helen M Achat, Shopna Bag, Leendert Moerkerken, Salwa Gabriel
The territory of a Local Health District (LHD) comprises multiple local government areas (LGAs). The recent amalgamation of several LGAs in metropolitan Sydney has resulted in two new LGAs being expanded across multiple LHDs, resulting in nonconcordance of boundaries. Here, we discuss the implications for planning health activities and service delivery, and ways to address them.
June 14, 2018: Public Health Research & Practice
https://www.readbyqxmd.com/read/29925070/osmoregulation-in-polycystic-kidney-disease-relationship-with-cystogenesis-and-hypertension
#5
Conor F Underwood, Jacqueline K Phillips, Cara M Hildreth
Polycystic kidney disease (PKD) is a group of monogenetic conditions characterised by the progressive accumulation of multiple renal cysts and hypertension. One of the earliest features of PKD is a reduction in urinary concentrating capacity that impairs extracellular fluid conservation. Urinary concentrating impairment predisposes PKD patients to periods of hypohydration when fluid loss is not adequately compensated by fluid intake. The hypohydrated state provides a blood hyperosmotic stimulus for vasopressin release to minimise further water loss...
2018: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29925063/targeting-shp-1-2-and-ship-pathways-a-novel-strategy-for-cancer-treatment
#6
REVIEW
Wolfram C M Dempke, Peter Uciechowski, Klaus Fenchel, Timothy Chevassut
Well-balanced levels of tyrosine phosphorylation, maintained by the reversible and coordinated actions of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs), are critical for a wide range of cellular processes including growth, differentiation, metabolism, migration, and survival. Aberrant tyrosine phosphorylation, as a result of a perturbed balance between the activities of PTKs and PTPs, is linked to the pathogenesis of numerous human diseases, including cancer, suggesting that PTPs may be innovative molecular targets for cancer treatment...
June 20, 2018: Oncology
https://www.readbyqxmd.com/read/29925054/influence-of-interspecific-interactions-on-avoidance-response-to-contamination
#7
Daniel C V R Silva, Cristiano V M Araújo, Rodrigo J Marassi, Sheila Cardoso-Silva, Morun B Neto, Gilmar C Silva, Rui Ribeiro, Flávio T Silva, Teresa C B Paiva, Marcelo L M Pompêo
An increasing number of studies have shown the ability of organisms to escape from toxic effects due to contamination, by moving spatially towards less contaminated habitats. However, this issue has been investigated in monospecific scenarios, without considering possible interactions between species during the contamination avoidance process. It is widely known that the spatial distribution of one species can be affected by another one, in different ways. Therefore, the main question addressed in the present study was as follows: Might interspecific interaction between the freshwater fish Danio rerio (zebrafish) and Poecilia reticulata (guppy) change their behavior patterns in terms of avoidance in the presence of a copper gradient? Zebrafish and guppies exposed to a copper gradient were tested for avoidance responses in a free-choice, non-forced, static, multi-compartmented exposure system, using two distinct approaches: (1) monospecific tests, in which only one species was exposed to the copper gradient, at two different population densities; and (2) multispecific tests, in which both species were tested simultaneously...
June 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29925049/anionic-and-cationic-drug-sorption-on-interpolyelectrolyte-complexes
#8
C R M de Lima, D N Gomes, J R de Morais Filho, M R Pereira, J L C Fonseca
Interpolyelectrolyte complexes of chitosan and poly(sodium 4-styrenesulfonate) [NaPSS] were synthesized and obtained in the form of solid particles, with two different sulfonate to aminium molar ratios: 0.7, resulting in particles with positive zeta potential (IPEC+ ), and 1.4, yielding particles with negative zeta potential (IPEC- ). Both particles were characterized as potential drug sorbents using differently charged drugs: sodium cromoglycate (negatively charged), and tetracycline hydrochloride (positively charged)...
June 15, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29925026/cargos-rotate-at-microtubule-intersections-during-intracellular-trafficking
#9
Yuan Gao, Stephen M Anthony, Yanqi Yu, Yi Yi, Yan Yu
Intracellular cargos are transported by molecular motors along actin and microtubules, but how their dynamics depends on the complex structure of the cytoskeletal network remains unclear. In this study, we investigated this longstanding question by measuring simultaneously the rotational and translational dynamics of cargos at microtubule intersections in living cells. We engineered two-faced particles that are fluorescent on one hemisphere and opaque on the other and used their optical anisotropy to report the rotation of cargos...
June 19, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29925022/fscs-reveals-the-complexity-of-lipid-domain-dynamics-in-the-plasma-membrane-of-live-cells
#10
Philip R Nicovich, Joanna M Kwiatek, Yuanqing Ma, Aleš Benda, Katharina Gaus
The coexistence of lipid domains with different degrees of lipid packing in the plasma membrane of mammalian cells has been postulated, but direct evidence has so far been challenging to obtain because of the small size and short lifetime of these domains in live cells. Here, we use fluorescence spectral correlation spectroscopy in conjunction with a probe sensitive to the membrane environment to quantify spectral fluctuations associated with dynamics of membrane domains in live cells. With this method, we show that membrane domains are present in live COS-7 cells and have a lifetime lower bound of 5...
June 19, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29925006/notch-signaling-facilitates-in-vitro-generation-of-cross-presenting-classical-dendritic-cells
#11
Margaret E Kirkling, Urszula Cytlak, Colleen M Lau, Kanako L Lewis, Anastasia Resteu, Alireza Khodadadi-Jamayran, Christian W Siebel, Hélène Salmon, Miriam Merad, Aristotelis Tsirigos, Matthew Collin, Venetia Bigley, Boris Reizis
The IRF8-dependent subset of classical dendritic cells (cDCs), termed cDC1, is important for cross-priming cytotoxic T cell responses against pathogens and tumors. Culture of hematopoietic progenitors with DC growth factor FLT3 ligand (FLT3L) yields very few cDC1s (in humans) or only immature "cDC1-like" cells (in the mouse). We report that OP9 stromal cells expressing the Notch ligand Delta-like 1 (OP9-DL1) optimize FLT3L-driven development of cDC1s from murine immortalized progenitors and primary bone marrow cells...
June 19, 2018: Cell Reports
https://www.readbyqxmd.com/read/29925005/piwi-nuclear-localization-and-its-regulatory-mechanism-in-drosophila-ovarian-somatic-cells
#12
Ryu Yashiro, Yukiko Murota, Kazumichi M Nishida, Haruna Yamashiro, Kaede Fujii, Asuka Ogai, Soichiro Yamanaka, Lumi Negishi, Haruhiko Siomi, Mikiko C Siomi
In Drosophila ovarian somatic cells (OSCs), Piwi represses transposons transcriptionally to maintain genome integrity. Piwi nuclear localization requires the N terminus and PIWI-interacting RNA (piRNA) loading of Piwi. However, the underlying mechanism remains unknown. Here, we show that Importinα (Impα) plays a pivotal role in Piwi nuclear localization and that Piwi has a bipartite nuclear localization signal (NLS). Impα2 and Impα3 are highly expressed in OSCs, whereas Impα1 is the least expressed. Loss of Impα2 or Impα3 forces Piwi to be cytoplasmic, which is rectified by overexpression of any Impα members...
June 19, 2018: Cell Reports
https://www.readbyqxmd.com/read/29924995/age-related-decline-in-primary-cd8-t-cell-responses-is-associated-with-the-development-of-senescence-in-virtual-memory-cd8-t-cells
#13
Kylie M Quinn, Annette Fox, Kim L Harland, Brendan E Russ, Jasmine Li, Thi H O Nguyen, Liyen Loh, Moshe Olshanksy, Haroon Naeem, Kirill Tsyganov, Florian Wiede, Rosela Webster, Chantelle Blyth, Xavier Y X Sng, Tony Tiganis, David Powell, Peter C Doherty, Stephen J Turner, Katherine Kedzierska, Nicole L La Gruta
Age-associated decreases in primary CD8+ T cell responses occur, in part, due to direct effects on naive CD8+ T cells to reduce intrinsic functionality, but the precise nature of this defect remains undefined. Aging also causes accumulation of antigen-naive but semi-differentiated "virtual memory" (TVM ) cells, but their contribution to age-related functional decline is unclear. Here, we show that TVM cells are poorly proliferative in aged mice and humans, despite being highly proliferative in young individuals, while conventional naive T cells (TN cells) retain proliferative capacity in both aged mice and humans...
June 19, 2018: Cell Reports
https://www.readbyqxmd.com/read/29924993/single-molecule-characterization-of-the-interactions-between-extracellular-chaperones-and-toxic-%C3%AE-synuclein-oligomers
#14
Daniel R Whiten, Dezerae Cox, Mathew H Horrocks, Christopher G Taylor, Suman De, Patrick Flagmeier, Laura Tosatto, Janet R Kumita, Heath Ecroyd, Christopher M Dobson, David Klenerman, Mark R Wilson
The aberrant aggregation of α-synuclein is associated with several human diseases, collectively termed the α-synucleinopathies, which includes Parkinson's disease. The progression of these diseases is, in part, mediated by extracellular α-synuclein oligomers that may exert effects through several mechanisms, including prion-like transfer, direct cytotoxicity, and pro-inflammatory actions. In this study, we show that two abundant extracellular chaperones, clusterin and α2 -macroglobulin, directly bind to exposed hydrophobic regions on the surface of α-synuclein oligomers...
June 19, 2018: Cell Reports
https://www.readbyqxmd.com/read/29924990/hif1%C3%AE-deletion-limits-tissue-regeneration-via-aberrant-b-cell-accumulation-in-experimental-pancreatitis
#15
Kyoung Eun Lee, Michelle Spata, Richard Maduka, Robert H Vonderheide, M Celeste Simon
Pancreatitis is an inflammatory disease of the exocrine pancreas and ranks among the most common gastrointestinal disorders. Inflamed tissues frequently experience conditions of insufficient oxygen availability, or hypoxia. Here, we demonstrate that hypoxia and consequent stabilization of the hypoxia-inducible factor 1α (HIF1α) transcription factor occur in murine and human pancreatitis. Mice lacking pancreas-specific HIF1α expression display markedly impaired pancreatic regeneration following cerulein-induced pancreatitis, which is associated with excessive intrapancreatic B cell accumulation...
June 19, 2018: Cell Reports
https://www.readbyqxmd.com/read/29924977/transcription-factor-pu-1-represses-and-activates-gene-expression-in-early-t-cells-by-redirecting-partner-transcription-factor-binding
#16
Hiroyuki Hosokawa, Jonas Ungerbäck, Xun Wang, Masaki Matsumoto, Keiichi I Nakayama, Sarah M Cohen, Tomoaki Tanaka, Ellen V Rothenberg
Transcription factors normally regulate gene expression through their action at sites where they bind to DNA. However, the balance of activating and repressive functions that a transcription factor can mediate is not completely understood. Here, we showed that the transcription factor PU.1 regulated gene expression in early T cell development both by recruiting partner transcription factors to its own binding sites and by depleting them from the binding sites that they preferred when PU.1 was absent. The removal of partner factors Satb1 and Runx1 occurred primarily from sites where PU...
June 19, 2018: Immunity
https://www.readbyqxmd.com/read/29924974/why-innate-lymphoid-cells
#17
REVIEW
Maya E Kotas, Richard M Locksley
Innate lymphoid cells (ILCs) are positioned in tissues perinatally, constitutively express receptors responsive to their organ microenvironments, and perform an arsenal of effector functions that overlap those of adaptive CD4+ T cells. Based on knowledge regarding subsets of invariant-like lymphocytes (e.g., natural killer T [NKT] cells, γδ T cells, mucosal-associated invariant T [MAIT] cells, etc.) and fetally derived macrophages, we hypothesize that immune cells established during the perinatal period-including, but not limited to, ILCs-serve intimate roles in tissue that go beyond classical understanding of the immune system in microbial host defense...
June 19, 2018: Immunity
https://www.readbyqxmd.com/read/29924957/a-survey-of-canine-respiratory-pathogens-in-new-zealand-dogs
#18
H R Sowman, N J Cave, M Dunowska
AIMS: To determine which of the common canine respiratory pathogens circulate among selected populations of healthy and diseased dogs in New Zealand. METHODS: Coagulated blood samples for serology and oropharyngeal swabs for virology were collected from healthy dogs (n=47) and from dogs with acute respiratory disease (n=49). For diseased dogs a convalescent blood sample was also collected 3-4 weeks later. Oropharyngeal swabs were subjected to virus isolation and tested for canine parainfluenza virus (CPIV), canine adenovirus (CAdV) 2, canine herpesvirus (CHV), canine respiratory coronavirus (CRCoV), canine influenza virus (CIV), canine distemper virus (CDV), Bordetella bronchiseptica, Streptococcus equi subsp...
June 20, 2018: New Zealand Veterinary Journal
https://www.readbyqxmd.com/read/29924955/sodium-thiosulfate-for-protection-from-cisplatin-induced-hearing-loss
#19
Penelope R Brock, Rudolf Maibach, Margaret Childs, Kaukab Rajput, Derek Roebuck, Michael J Sullivan, Véronique Laithier, Milind Ronghe, Patrizia Dall'Igna, Eiso Hiyama, Bénédicte Brichard, Jane Skeen, M Elena Mateos, Michael Capra, Arun A Rangaswami, Marc Ansari, Catherine Rechnitzer, Gareth J Veal, Anna Covezzoli, Laurence Brugières, Giorgio Perilongo, Piotr Czauderna, Bruce Morland, Edward A Neuwelt
Background Cisplatin chemotherapy and surgery are effective treatments for children with standard-risk hepatoblastoma but may cause considerable and irreversible hearing loss. This trial compared cisplatin with cisplatin plus delayed administration of sodium thiosulfate, aiming to reduce the incidence and severity of cisplatin-related ototoxic effects without jeopardizing overall and event-free survival. Methods We randomly assigned children older than 1 month and younger than 18 years of age who had standard-risk hepatoblastoma (≤3 involved liver sectors, no metastatic disease, and an alpha-fetoprotein level of >100 ng per milliliter) to receive cisplatin alone (at a dose of 80 mg per square meter of body-surface area, administered over a period of 6 hours) or cisplatin plus sodium thiosulfate (at a dose of 20 g per square meter, administered intravenously over a 15-minute period, 6 hours after the discontinuation of cisplatin) for four preoperative and two postoperative courses...
June 21, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29924942/deficient-neurotrophic-factors-of-cspg4-type-neural-cell-exosomes-in-alzheimer-disease
#20
Edward J Goetzl, Carlos Nogueras-Ortiz, Maja Mustapic, Roger J Mullins, Erin L Abner, Janice B Schwartz, Dimitrios Kapogiannis
Exosomes derived from chondroitin sulfate proteoglycan (CSPG) 4 type neural precursor cells (CSPG4Es) were purified from human plasma by sequential immunoabsorption with anti-CSPG4 and anti-platelet growth factor receptor α mAb to characterize the potential in vivo roles of CSPG4 cells in neuronal repair. Hepatocyte growth factor, fibroblast growth factors (FGFs)-2 and -13, and type 1 insulin-like growth factor (IGF-1), which enhance neuronal survival and functions, were quantified in CSPG4E extracts. For CSPG4Es of 24 healthy control subjects, mean levels of hepatocyte growth factor, FGF-13, and IGF-1, but not FGF-2, were significantly higher by up to 7-fold than in their neuronal-derived exosomes, and mean levels of all 4 growth factors were significantly higher by up to 8-fold than in their astrocyte-derived exosomes...
June 20, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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