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Vaginal atrophy

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https://www.readbyqxmd.com/read/29347848/role-of-topical-oxytocin-in-improving-vaginal-atrophy-in-postmenopausal-women-a-randomized-controlled-trial
#1
H A Torky, A Taha, H Marie, E El-Desouky, O Raslan, A A Moussa, A M Ahmad, A Abo-Louz, S Zaki, T Fares, A Eesa
OBJECTIVE AND DESIGN: Prospective randomized controlled trial to test the effectiveness of topical oxytocin gel to improve vaginal atrophy in postmenopausal women. PATIENTS AND METHODS: A total of 140 postmenopausal women presenting with vaginal atrophy and who satisfied the inclusion and exclusion criteria were randomized into two groups each of 70 patients; they received intravaginal oxytocin gel or placebo gel for 30 days. Serum estrogen level, visual, colposcopic and histological vaginal examination were performed before and after treatment...
January 19, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29344000/visible-near-infrared-spectroscopic-assessment-of-urogenital-tissue-in-premenopausal-and-postmenopausal-women
#2
Miranda A Farage, Tom Cambron, Kan-Zhi Liu
Background: A clinical study was conducted to evaluate the feasibility of using visible and near-infrared (NIR) spectroscopy as a potential noninvasive measure of genital skin health in premenopausal and postmenopausal women. Methods: A total of 45 female subjects (aged 21-70 years), all of whom gave fully informed consent to participate, were enrolled in the study and assigned to 1 of 3 groups: 15 premenopausal (Pre-M), 15 postmenopausal receiving hormone replacement therapy (Post-M HRT), and 15 postmenopausal receiving no form of hormone replacement therapy (Post-M non-HRT)...
2018: Clinical Medicine Insights. Women's Health
https://www.readbyqxmd.com/read/29315133/vaginal-health-of-postmenopausal-women-on-nutraceutical-containing-equol
#3
Salvatore Caruso, Stefano Cianci, Valentina Fava, Agnese M C Rapisarda, Silvia Cutello, Antonio Cianci
OBJECTIVE: The aim of the study was to evaluate the effects of nutraceuticals containing equol on vaginal health of postmenopausal women with vulvovaginal symptoms and dyspareunia. METHODS: One hundred twenty-six natural postmenopausal women on +1b +1c (2 and 3-6 y after the final menstrual period, respectively) of the Stages of Reproductive Aging Workshop were enrolled in a nonrandomized trial. Of these, 72 women accepted to use nutraceutical (group A). The remaining 54 women refused the treatment and participated as the control group (group B)...
January 8, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29290210/the-most-bothersome-symptom-of-vaginal-atrophy-evidence-from-the-observational-agata-study
#4
Federica Palma, Anjeza Xholli, Angelo Cagnacci
OBJECTIVES: Vaginal atrophy (VA) is a chronic medical condition. It is managed unsatisfactorily, despite its high prevalence and negative impact on female quality of life. In order to meet their needs, it would be useful to know what women perceive to be the most bothersome symptom (MBS) of VA. STUDY DESIGN: Cross-sectional, multicenter study of 913 postmenopausal women consulting 22 gynecological outpatient services. MAIN OUTCOME MEASURES: Prevalence of the MBS perceived by postmenopausal women of different age and vaginal condition...
February 2018: Maturitas
https://www.readbyqxmd.com/read/29286987/a-systematic-review-of-intravaginal-testosterone-for-the-treatment-of-vulvovaginal-atrophy
#5
Robin J Bell, Farwa Rizvi, Rakabul M Islam, Susan R Davis
OBJECTIVES: Intravaginal testosterone has emerged as a potential treatment for vulvovaginal atrophy (VVA) in women, in general, and women taking an aromatase inhibitor (AI). A systematic review of the literature was undertaken to determine whether available clinical trial data support efficacy and safety of intravaginal testosterone for the treatment of VVA. METHODS: Scopus, MEDLINE, EMBASE, and the Cochrane Library databases were systematically searched on July 26, 2017, for human studies published in English of clinical trials of intravaginal testosterone...
December 28, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29286986/fractional-microablative-co2-laser-in-breast-cancer-survivors-affected-by-iatrogenic-vulvovaginal-atrophy-after-failure-of-nonestrogenic-local-treatments-a-retrospective-study
#6
Tiziana Pagano, Pasquale De Rosa, Roberta Vallone, Francesco Schettini, Grazia Arpino, Mario Giuliano, Rossella Lauria, Irene De Santo, Alessandro Conforti, Alessandra Gallo, Giovanni Nazzaro, Sabino De Placido, Mariavittoria Locci, Giuseppe De Placido
OBJECTIVE: Vulvovaginal atrophy (VVA) is a condition frequently observed in menopause. Its symptoms can significantly affect the quality of life of patients. Since VVA is related to estrogen deficiency, chemotherapy and hormone therapy for breast cancer (BC) might cause VVA by inducing menopause. Given the lack of effective treatment for VVA in BC survivors, we retrospectively evaluated the efficacy and tolerability of fractional microablative CO2 laser therapy in these patients. METHODS: We treated 82 BC survivors with three cycles of CO2 laser after failure of topical nonestrogenic therapy...
December 28, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29239462/isoflavones-derived-from-glycine-max-l-merr-in-the-treatment-of-vaginal-atrophy-a-new-frontier
#7
Sônia Maria Rolim Rosa Lima, Adriana Bittencourt Campaner, Antonio Pedro Flores Auge
No abstract text is available yet for this article.
September 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29234255/influence-of-orally-administered-probiotic-lactobacillus-strains-on-vaginal-microbiota-in-women-with-breast-cancer-during-chemotherapy-a-randomized-placebo-controlled-double-blinded-pilot-study
#8
Julian Marschalek, Alex Farr, Marie-Louise Marschalek, Konrad J Domig, Wolfgang Kneifel, Christian F Singer, Herbert Kiss, Ljubomir Petricevic
Background: Due to chemotherapy and estrogen deprivation therapy, genitourinary syndrome of menopause is a common condition in breast cancer patients. We aimed to determine the effect of an orally administered Lactobacillus preparation on the vaginal microbiota in breast cancer patients. Methods: Postmenopausal breast cancer patients receiving chemotherapy, with vaginal atrophy and an intermediate vaginal microbiota (Nugent score 4-6), were either randomized to the intervention group receiving probiotic capsules of 4 Lactobacillus species or to the control group receiving placebo twice daily for 2 weeks...
October 2017: Breast Care
https://www.readbyqxmd.com/read/29227723/interventions-to-address-sexual-problems-in-people-with-cancer-american-society-of-clinical-oncology-clinical-practice-guideline-adaptation-of-cancer-care-ontario-guideline
#9
Jeanne Carter, Christina Lacchetti, Barbara L Andersen, Debra L Barton, Sage Bolte, Shari Damast, Michael A Diefenbach, Katherine DuHamel, Judith Florendo, Patricia A Ganz, Shari Goldfarb, Sigrun Hallmeyer, David M Kushner, Julia H Rowland
Purpose The adaptation of the Cancer Care Ontario (CCO) guideline Interventions to Address Sexual Problems in People With Cancer provides recommendations to manage sexual function adverse effects that occur as a result of cancer diagnosis and/or treatment. Methods ASCO staff reviewed the guideline for developmental rigor and updated the literature search. An ASCO Expert Panel ( Table A1 ) was assembled to review the guideline content and recommendations. Results The ASCO Expert Panel determined that the recommendations from the 2016 CCO guideline are clear, thorough, and based upon the most relevant scientific evidence...
December 11, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29202940/genitourinary-syndrome-of-menopause-management-strategies-for-the-clinician
#10
REVIEW
Stephanie S Faubion, Richa Sood, Ekta Kapoor
Genitourinary syndrome of menopause (GSM), previously known as atrophic vaginitis or vulvovaginal atrophy, affects more than half of postmenopausal women. Caused by low estrogen levels after menopause, it results in bothersome symptoms, including vaginal dryness, itching, dyspareunia, urinary urgency and increased frequency, and urinary tract infections. Even though women with GSM can have sexual dysfunction that interferes with partner relationships, women are often embarrassed to seek treatment, and health care professionals do not always actively screen for GSM...
December 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29193980/a-randomized-multicenter-double-blind-study-to-evaluate-the-safety-and-efficacy-of-estradiol-vaginal-cream-0-003-in-postmenopausal-women-with-vaginal-dryness-as-the-most-bothersome-symptom
#11
David F Archer, Thomas D Kimble, F D Yuhua Lin, Simona Battucci, Vilma Sniukiene, James H Liu
BACKGROUND: Vulvovaginal atrophy (VVA) is characterized by vaginal/vulvar dryness, irritation, dyspareunia, or dysuria. The objective of this study was to examine the efficacy and safety of a very low-dose estradiol vaginal cream (0.003%) applied twice per week in postmenopausal women with VVA-related vaginal dryness. MATERIALS AND METHODS: In this phase 3, randomized, double-blind, placebo-controlled, multicenter study, postmenopausal women with moderate-severe vaginal dryness as the most bothersome VVA symptom were randomized (1:1) to estradiol cream 0...
December 1, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/29188324/total-vaginectomy-and-urethral-lengthening-at-time-of-neourethral-prelamination-in-transgender-men
#12
Carlos A Medina, Lydia A Fein, Christopher J Salgado
INTRODUCTION AND HYPOTHESIS: For transgender men (TGM), gender-affirmation surgery (GAS) is often the final stage of their gender transition. GAS involves creating a neophallus, typically using tissue remote from the genital region, such as radial forearm free-flap phalloplasty. Essential to this process is vaginectomy. Complexity of vaginal fascial attachments, atrophy due to testosterone use, and need to preserve integrity of the vaginal epithelium for tissue rearrangement add to the intricacy of the procedure during GAS...
November 29, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/29170793/clinical-predictors-and-risk-factors-for-vaginal-mesh-extrusion
#13
Usah Khrucharoen, Patkawat Ramart, Judy Choi, Diana Kang, Ja-Hong Kim, Shlomo Raz
PURPOSES: Our study aims to enhance the accuracy of the clinical diagnosis in patients with vaginal mesh extrusion following transvaginal mesh placement for pelvic organ prolapse using significant clinical parameters and risk factors. METHODS: All patients who underwent vaginal mesh removal were retrospectively reviewed from January 2000 to May 2014. Eligible patients were divided into two groups according to the presence of vaginal mesh extrusion. RESULTS: A total of 862 patients, 798 were included...
November 24, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29140150/radiotherapy-for-cervical-cancer-impact-on-the-vaginal-epithelium-and-sexual-function
#14
Alexandra Hofsjö, Karin Bergmark, Bo Blomgren, Helen Jahren, Nina Bohm-Starke
BACKGROUND: Women who have been treated for cervical cancer have persistent changes in their sexual function, which result in considerable distress. The aim of this study was to investigate the morphology of the vaginal epithelium in cervical cancer survivors treated with radiotherapy and its correlation to serum levels of sex steroid hormones and sexual function. MATERIAL AND METHODS: We included 34 patients treated for cervical cancer with radiotherapy and 37 healthy age-matched control women scheduled for benign gynecological surgery...
November 15, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29104812/evaluation-of-the-co2-laser-therapy-on-vulvo-vaginal-atrophy-vva-in-oncological-patients-preliminary-results
#15
Isabella Pagano, Stefania Gieri, Francesca Nocera, Giuseppe Scibilia, Filippo Fraggetta, Antonio Galia, Mauro Gioè, Basilio Pecorino, Paolo Scollo
Objective: To evaluate the impact of fractionated CO2 laser therapy on vaginal atrophy and mild/moderate stress urinary incontinence (SUI) symptoms in patients with physiological or surgically-induced menopause. Materials and Methods: Post-menopausal patients (n = 33) presenting vaginal atrophy and/or SUI, underwent three vaginal CO2 laser treatment sessions, performed at 1-month intervals. Vaginal symptoms were evaluated using the Vaginal Health Index Score (VHI-S), Visual Analogue Scales (VAS) for dyspareunia and global patient satisfaction...
May 2017: Journal of Cancer Therapy
https://www.readbyqxmd.com/read/29064335/overall-safety-of-ospemifene-in-postmenopausal-women-from-placebo-controlled-phase-2-and-3-trials
#16
James A Simon, Corrado Altomare, Susannah Cort, Wei Jiang, JoAnn V Pinkerton
OBJECTIVE: To evaluate the safety of daily oral ospemifene 60 mg, estrogen agonist/antagonist, used to treat moderate-to-severe dyspareunia due to postmenopausal vulvovaginal atrophy, which is part of genitourinary syndrome of menopause. METHODS: Post hoc analysis of safety data (treatment-emergent adverse events [TEAEs]) pooled from six phase 2 and 3 randomized, double-blind, multicenter placebo-controlled studies, evaluating the effects of ospemifene 60 mg on the breast, cardiovascular system, and bone in postmenopausal women...
October 24, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/29061288/co2-laser-treatment-is-effective-for-symptoms-of-vaginal-atrophy-no
#17
Ekene A Enemchukwu
No abstract text is available yet for this article.
December 2017: Journal of Urology
https://www.readbyqxmd.com/read/29061287/co2-laser-treatment-is-effective-for-symptoms-of-vaginal-atrophy
#18
Jennifer T Anger
No abstract text is available yet for this article.
December 2017: Journal of Urology
https://www.readbyqxmd.com/read/29057583/a-medical-device-containing-purified-bovine-colostrum-monurelle-biogel-in-the-treatment-of-vulvovaginal-atrophy-in-postmenopausal-women-retrospective-analysis-of-urinary-symptoms-sexual-function-and-quality-of-life
#19
M C Schiavi, C Di Tucci, V Colagiovanni, P Faiano, A Giannini, O D'Oria, G Prata, G Perniola, M Monti, M A Zullo, L Muzii, P Benedetti Panici
OBJECTIVE: This study assessed the effectiveness and safety of a medical device containing purified bovine colostrum (Monurelle Biogel; Zambon, Bresso, Italy) in improving vulvovaginal atrophy (VVA), sexual function, urinary symptoms, and quality of life (QoL) in postmenopausal women. METHODS: In all, 172 postmenopausal women with VVA were included in the study. All women were treated with vaginal Monurelle Biogel daily for 12 weeks. Patients underwent clinical examinations, completed a 3-day voiding diary, and had VVA graded using the Vaginal Health Index (VHI) at baseline and 12 weeks...
October 23, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/29044352/-sulphurous-vaginal-douching-and-vulvovaginal-atrophy
#20
M Costantino, V Conti, M B Marongiu, G Napolano, A Filippelli
OBJECTIVE: During climacteric the reduction or interruption of estrogenic stimulus determines a gradual atrophy of the tissues of the urogenital tract.Vulvovaginal atrophy can be cause of dryness, itch, burning, and dyspareunia. Vulvovaginal atrophy is associated also with depression. Hence the importance of an appropriate treatment of the vulvovaginal atrophy. Between therapeutic options we can add, particularly for women who suffer only from vaginal symptoms, the spa therapy that uses mineral waters with benefic effects on vaginal tissue wellness and health...
September 2017: La Clinica Terapeutica
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