Diane L Downie, Preetika Rao, Corinne David-Ferdon, Sean Courtney, Justin S Lee, Shannon Kugley, Pia D M MacDonald, Keegan Barnes, Shelby Fisher, Joanne L Andreadis, Jasmine Chaitram, Matthew R Mauldin, Reynolds M Salerno, Jarad Schiffer, Adi V Gundlapalli
To better identify emerging or reemerging pathogens in patients with difficult-to-diagnose infections, it is important to improve access to advanced molecular testing methods. This is particularly relevant for cases where conventional microbiologic testing has been unable to detect the pathogen and the patient's specimens test negative. To assess the availability and utility of such testing for human clinical specimens, a literature review of published biomedical literature was conducted. From a corpus of more than 4,000 articles, a set of 34 reports was reviewed in detail for data on where the testing was being performed, types of clinical specimens tested, pathogen agnostic techniques and methods used, and results in terms of potential pathogens identified...
April 12, 2024: Health Security