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Critical stress management

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https://www.readbyqxmd.com/read/28821727/grace-satellite-observations-reveal-the-severity-of-recent-water-over-consumption-in-the-united-states
#1
Kurt C Solander, John T Reager, Yoshihide Wada, James S Famiglietti, Richard S Middleton
Changes in the climate and population growth will critically impact the future supply and demand of water, leading to large uncertainties for sustainable resource management. In the absence of on-the-ground measurements to provide spatially continuous, high-resolution information on water supplies, satellite observations can provide essential insight. Here, we develop a technique using observations from the Gravity Recovery and Climate Experiment (GRACE) satellite to evaluate the sustainability of surface water and groundwater use over the continental United States...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28820232/recognizing-and-managing-adrenal-disorders-in-the-emergency-department
#2
Amy Cutright, Stephen Ducey, Claudia L. Barthold
Primary and secondary adrenal insufficiency are underrecognized conditions among emergency department patients, affecting an estimated 10% to 20% of critically ill patients. The signs and symptoms of cortisol deficit can be nonspecific and wide-ranging, and identification and swift treatment with stress-dosing of hydrocortisone is vital to avoid life-threatening adrenal crisis. Laboratory evaluation focuses on identification of electrolyte abnormalities typical of adrenal insufficiency, and while additional testing may depend on the type and severity of symptoms, it should not delay corticosteroid replacement...
September 2017: Emergency Medicine Practice
https://www.readbyqxmd.com/read/28819083/the-forgotten-realm-of-the-new-and-emerging-psychosocial-risk-factors
#3
Francesco Chirico
In Europe, employers of all private and public enterprises have a legal obligation to protect their employers by all the different types of workplace hazards to the safety and health of workers. The most important methods developed for the work-related stress risk assessment are based on the Cox's research commissioned by European Agency for Safety and Health at Work (EU-OSHA) and are the Management Standard HSE for work-related stress in United Kingdom, the START method in Germany, the Screening, Observation, Analysis, Expertise (SOBANE) in Belgium, and the National Institute for Prevention and Safety at Work (INAIL-ISPESL) model in Italy, the latter based on the British Management Standard...
August 17, 2017: Journal of Occupational Health
https://www.readbyqxmd.com/read/28816059/atherothrombosis-and-oxidative-stress-mechanisms-and-management-in-elderly
#4
Francesco Violi, Lorenzo Loffredo, Roberto Carnevale, Pasquale Pignatelli, Daniele Pastori
SIGNIFICANCE The incidence of cardiovascular events increases by aging, representing the main cause of death in old population. Aging is associated with over-production of reactive oxygen species (ROS), which may affect clotting and platelet activation, and impair endothelial function so predisposing elderly patients to thrombotic complications. RECENT ADVANCES There are increasing evidences to suggest that aging is associated with an imbalance between oxidative stress and antioxidant status. Thus, up-regulation of ROS-producing enzymes such as nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and myeloperoxidase, along with down-regulation of antioxidant enzymes, such as superoxide dismutase and glutathione peroxidase, occur during aging...
August 17, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28813439/comparative-ecophysiology-of-a-critically-endangered-cr-ectotherm-implications-for-conservation-management
#5
Andrea F T Currylow, Angelo Mandimbihasina, Paul Gibbons, Ernest Bekarany, Craig B Stanford, Edward E Louis, Daniel E Crocker
Captive breeding is a vital conservation tool for many endangered species programs. It is often a last resort when wild animal population numbers drop to below critical minimums for natural reproduction. However, critical ecophysiological information of wild counterparts may not be well documented or understood, leading to years of minimal breeding successes. We collected endocrine and associated ecological data on a critically endangered ectotherm concurrently in the wild and in captivity over several years...
2017: PloS One
https://www.readbyqxmd.com/read/28801400/protein-misfolding-amyotrophic-lateral-sclerosis-and-guanabenz-protocol-for-a-phase-ii-rct-with-futility-design-promise-trial
#6
Eleonora Dalla Bella, Irene Tramacere, Giovanni Antonini, Giuseppe Borghero, Margherita Capasso, Claudia Caponnetto, Adriano Chiò, Massimo Corbo, Roberto Eleopra, Massimiliano Filosto, Fabio Giannini, Enrico Granieri, Vincenzo La Bella, Christian Lunetta, Jessica Mandrioli, Letizia Mazzini, Sonia Messina, Maria Rosaria Monsurrò, Gabriele Mora, Nilo Riva, Romana Rizzi, Gabriele Siciliano, Vincenzo Silani, Isabella Simone, Gianni Sorarù, Paolo Volanti, Giuseppe Lauria
INTRODUCTION: Recent studies suggest that endoplasmic reticulum stress may play a critical role in the pathogenesis of amyotrophic lateral sclerosis (ALS) through an altered regulation of the proteostasis, the cellular pathway-balancing protein synthesis and degradation. A key mechanism is thought to be the dephosphorylation of eIF2α, a factor involved in the initiation of protein translation. Guanabenz is an alpha-2-adrenergic receptor agonist safely used in past to treat mild hypertension and is now an orphan drug...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28799488/environment-and-neurodegenerative-diseases-an-update-on-mirna-role
#7
Margherita Ferrante, Gea Oliveri Conti
INTRODUCTION: The importance of neurodegenerative diseases on the management of public health is growing and the real role of the environment and miRNA in their occurrence is still unclear. miRNA can affect significantly the regulatory network. The complex variety and gene-regulatory capacity of miRNAs is particularly valuable in the brain, being a very complex organ with a functional specialization of neurons highly adaptable to environmental stimuli. In particular a miRNAs role is demonstrated in neurological diseases as the effect to toxic and mutagenic substances exposure by the environment...
August 11, 2017: MicroRNA
https://www.readbyqxmd.com/read/28795775/interventions-to-reduce-perceived-stress-among-graduate-students-a-systematic-review-with-implications-for-evidence-based-practice
#8
Susan B Stillwell, Amber L Vermeesch, Jane G Scott
BACKGROUND: Stress is a part of daily life for graduate students, including graduate nursing students. Contemporary graduate nursing students are facing unprecedented challenges to meet rigorous academic standards as they prepare for their advanced professional role to meet the demands of the nation's complex and ever-changing healthcare system. Empowering graduate nursing students to ease their perceived stress and minimize undesirable health effects may benefit their capacity to adapt and successfully manage perceived stress in their future healthcare role...
August 10, 2017: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/28793382/transitioning-into-new-clinical-areas-of-practice-an-integrative-review-of-the-literature
#9
REVIEW
Grant R Kinghorn, Elizabeth J Halcomb, Terry Froggatt, Stuart Dm Thomas
AIMS AND OBJECTIVES: This review aims to critically synthesise research related to the transition of Registered Nurses into new areas of clinical practice. BACKGROUND: Global workforce shortages and rising health care demands have encouraged Registered Nurses to move into new clinical settings. While a body of literature reports on the transition of newly qualified nurses, evidence surrounding the transition of more experienced Registered Nurses to new clinical areas remains poorly explored...
August 9, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28777812/workplace-social-support-in-job-satisfaction-among-veterans-with-posttraumatic-stress-symptoms-a-preliminary-correlational-study
#10
J I Harris, Thad Q Strom, Amanda G Ferrier-Auerbach, Matthew E Kaler, Lucas P Hansen, Christopher R Erbes
For Veterans managing PTSD symptoms, returning to vocational functioning is often challenging; identifying modifiable variables that can contribute to positive vocational adjustment is critical to improved vocational rehabilitation services. Workplace social support has proven to be important in vocational adjustment in both general population and vocational rehabilitation samples, but this area of inquiry has received little attention among Veterans with PTSD symptoms. In this small correlational study, employed Veterans (N = 63) presenting for outpatient PTSD treatment at a VA Health Care System completed surveys assessing demographic variables, PTSD symptoms, workplace social support, and job satisfaction...
2017: PloS One
https://www.readbyqxmd.com/read/28777112/the-relationship-between-professional-quality-of-life-and-caring-ability-in-critical-care-nurses
#11
Marzieh Mohammadi, Hamid Peyrovi, Mahmood Mahmoodi
BACKGROUND: Critical care nursing has some features that may affect the ability of critical care nurses to provide care. Professionals as critical care nurses who deal with peoples' health and life often experience some levels of stress that affects their quality of life. OBJECTIVE: This study examined the relationship between professional quality of life and caring ability of critical care nurses. METHOD: In this descriptive correlational study, 253 critical care nurses working in the medical and surgical intensive care units of Tehran University of Medical Sciences were recruited by convenience sampling method...
September 2017: Dimensions of Critical Care Nursing: DCCN
https://www.readbyqxmd.com/read/28774015/an-integrated-health-monitoring-method-for-structural-fatigue-life-evaluation-using-limited-sensor-data
#12
Jingjing He, Yibin Zhou, Xuefei Guan, Wei Zhang, Yanrong Wang, Weifang Zhang
A general framework for structural fatigue life evaluation under fatigue cyclic loading using limited sensor data is proposed in this paper. First, limited sensor data are measured from various sensors which are preset on the complex structure. Then the strain data at remote spots are used to obtain the strain responses at critical spots by the strain/stress reconstruction method based on empirical mode decomposition (REMD method). All the computations in this paper are directly performed in the time domain...
November 4, 2016: Materials
https://www.readbyqxmd.com/read/28763733/finding-the-sweet-spot-developing-implementing-and-evaluating-a-burn-out-and-compassion-fatigue-intervention-for-third-year-medical-trainees
#13
Tara Tucker, Maryse Bouvette, Shauna Daly, Pamela Grassau
Medical trainees are at high risk for developing burnout. Introducing trainees to the risks of burnout and supporting identification and proactive responses to their 'warning' signs of compassion fatigue (CF) is critical in building resiliency. The authors developed and evaluated a burnout and CF program for third year trainees at a Canadian Medical School. Of 165 medical trainees who participated in the burnout and CF program, 59 (36%) provided evaluation and feedback of the program and its impact throughout their year...
July 22, 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/28757318/new-treatment-option-for-copd-two-long-acting-bronchodilators-in-a-single-metered-dose-inhaler
#14
REVIEW
Timothy H Self, Samantha Ellingson
Combination long-acting inhaled bronchodilators are central to the management of moderate to very severe chronic obstructive pulmonary disease (COPD) patients. Glycopyrrolate is a long-acting muscarinic antagonist (LAMA), and formoterol fumarate is a long-acting beta2 agonist (LABA). In randomized controlled trials, this LAMA/LABA combination in a metered dose inhaler (MDI) was shown to be effective in improving pulmonary function and quality of life. Clinicians now have the availability of three delivery systems for LAMA/LABA therapy, including MDI, dry-powder inhaler, and Soft Mist inhaler...
July 27, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28756878/heme-oxygenase-1-a-new-druggable-target-in-the-management-of-chronic-and-acute-myeloid-leukemia
#15
REVIEW
Loredana Salerno, Giuseppe Romeo, Maria N Modica, Emanuele Amata, Valeria Sorrenti, Ignazio Barbagallo, Valeria Pittalà
Heme oxygenase-1 (HO-1) is the enzyme catalyzing the rate-limiting oxidative degradation of cellular heme into free iron, carbon monoxide (CO), and biliverdin, which is then rapidly converted into bilirubin. By means of these catabolic end-products and by removal of pro-oxidant heme, HO-1 exerts antioxidant, antiapoptotic, and immune-modulating effects, leading to overall cytoprotective and beneficial functions in mammalian cells. Therefore, HO-1 is considered a survival molecule in various stress-related conditions...
July 20, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28753109/anticipation-and-response-pandemic-influenza-in-malawi-2009
#16
Evanson Z Sambala, Lenore Manderson
BACKGROUND: In 2006, Malawi developed a national influenza plan to mitigate, prevent and manage the burden of infection should an outbreak occur. In 2009, it translated its contingency plan to respond to the unfolding influenza pandemic. However, little is known of how Malawi translated its national influenza plan into response actions, or the success of these responses. OBJECTIVE: To investigate how Malawi translated its preparedness plan and so broaden our understanding of the outcomes of the responses...
2017: Global Health Action
https://www.readbyqxmd.com/read/28738687/critical-incident-stress-debriefing-after-adverse-patient-safety-events
#17
Reema Harrison, Albert Wu
Adverse events (AEs) are common, estimated to occur in around 10% internationally. Although preventable harm can be minimized, when AEs occur it is important that they be managed appropriately. AEs can be traumatic not only for patients, their friends, and relatives, but also for the involved clinicians, who have been referred to as "second victims" in a growing body of international research. Despite the frequency with which AEs occur, organizational mechanisms for supporting staff in these circumstances are not routinely embedded in healthcare settings...
May 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28735096/lipid-droplet-functions-beyond-energy-storage
#18
REVIEW
Michael A Welte, Alex P Gould
Lipid droplets are cytoplasmic organelles that store neutral lipids and are critically important for energy metabolism. Their function in energy storage is firmly established and increasingly well characterized. However, emerging evidence indicates that lipid droplets also play important and diverse roles in the cellular handling of lipids and proteins that may not be directly related to energy homeostasis. Lipid handling roles of droplets include the storage of hydrophobic vitamin and signaling precursors, and the management of endoplasmic reticulum and oxidative stress...
July 19, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28729348/a-new-target-for-caffeine-in-the-developing-lung-endoplasmic-reticulum-stress
#19
Philipp Rath, Claudio Nardiello, Rory E Morty
The utility of caffeine to manage apnea of prematurity is widely accepted, however, much controversy surrounds the potential for caffeine to drive post-natal lung maturation in settings of arrested lung development. Many studies have reported pathways relevant to lung injury and lung development are modulated by caffeine in vitro and in vivo, leading to the application of caffeine in experimental animal models of bronchopulmonary dysplasia (BPD). These studies have generated exciting, but at times confusing data...
July 20, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28721596/central-adrenal-insufficiency-following-traumatic-brain-injury-a-missed-diagnosis-in-the-critically-injured
#20
Eileen Fan, Peter W Skippen, Michael A Sargent, David D Cochrane, Jean-Pierre Chanoine
BACKGROUND: High-dose steroid administration is no longer recommended in the treatment of acute traumatic brain injury (TBI) as it failed to prove beneficial in improving patients' outcome. However, a masked benefit of steroid administration in TBI management was that it provided corticosteroid replacement therapy in patients with TBI-related central adrenal insufficiency. CASE PRESENTATION: We report the case of a 12-year-old boy who suffered a severe TBI from a motor vehicle accident that resulted in complete deficiency of anterior pituitary function...
July 18, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
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