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Critical stress management

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https://www.readbyqxmd.com/read/29040553/longitudinal-depression-or-anxiety-in-mothers-and-offspring-asthma-a-swedish-population-based-study
#1
Bronwyn K Brew, Cecilia Lundholm, Alexander Viktorin, Paul Lichtenstein, Henrik Larsson, Catarina Almqvist
Background: Previous research has found that maternal stress during pregnancy increases the risk of offspring asthma. However, whether this association is consistent with a causal interpretation has never been tested. The objective is to determine whether there is a critical exposure period for maternal depression or anxiety on offspring asthma or whether cumulative exposure is most important, and to investigate evidence of confounding. Methods: The study population included all children born in Sweden from July 2006 to December 2009 (n = 360 526)...
September 23, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29040214/untreated-relative-hypotension-measured-as-perfusion-pressure-deficit-during-management-of-shock-and-new-onset-acute-kidney-injury-a-literature-review
#2
Rakshit Panwar
Maintaining an optimal blood pressure (BP) during shock is a fundamental tenet of critical care. Optimal BP targets maybe different for different patients. In current practice, too often, uniform BP targets are pursued which may result in inadvertently accepting a degree of untreated relative hypotension i.e., the deficit between patients' usual pre-morbid basal BP and the achieved BP, during vasopressor support. Relative hypotension is a common but an under-recognized and an under-treated sign among patients with potential shock state...
October 16, 2017: Shock
https://www.readbyqxmd.com/read/29033540/assay-development-and-high-throughput-screening-for-small-molecule-inhibitors-of-a-vibrio-cholerae-stress-response-pathway
#3
Laura Stanbery, Jyl S Matson
Antibiotics are important adjuncts to oral rehydration therapy in cholera disease management. However, due to the rapid emergence of resistance to the antibiotics used to treat cholera, therapeutic options are becoming limited. Therefore, there is a critical need to develop additional therapeutics to aid in the treatment of cholera. Previous studies showed that the extracytoplasmic stress response (σ(E)) pathway of Vibrio cholerae is required for full virulence of the organism. The pathway is also required for bacterial growth in the presence of ethanol...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29031841/management-of-post-radical-prostatectomy-urinary-incontinence-a-review
#4
REVIEW
Kushan D Radadia, Nicholas J Farber, Brian Shinder, Charles F Polotti, Lee J Milas, Hari Tunuguntla
Post-prostatectomy urinary incontinence (PPUI) has significant impact on the quality of life of patients who undergo radical prostatectomy. Stress and overflow incontinence may result from the procedure, with sphincteric incompetence and detrusor hypocontractility implicating their development, respectively. In many cases, treatment begins with conservative approaches, including pelvic floor muscle training/biofeedback. Pharmacotherapy can be used to treat overactive bladder. For stress incontinence, transurethral bulking agents are utilized in select patients, however AUS and male slings are the most efficacious options with good success rates...
October 11, 2017: Urology
https://www.readbyqxmd.com/read/28994362/perceived-workplace-interpersonal-support-among-workers-of-the-fukushima-daiichi-nuclear-power-plants-following-the-2011-accident-the-fukushima-nuclear-energy-workers-support-news-project-study
#5
Sho Takahashi, Jun Shigemura, Yoshitomo Takahashi, Soichiro Nomura, Aihide Yoshino, Takeshi Tanigawa
OBJECTIVE: The 2011 Fukushima Daiichi nuclear accident was the worst nuclear disaster since Chernobyl. The Daiichi workers faced multiple stressors (workplace trauma, victim experiences, and public criticism deriving from their company's post-disaster management). Literatures suggest the importance of workplace interpersonal support (WIS) in enhancing psychological health among disaster workers. We sought to elucidate the role of their demographics, disaster-related experiences, and post-traumatic stress symptoms on perceived WIS...
October 10, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28987864/food-stories-unraveling-the-mechanisms-underlying-healthful-eating
#6
Emily Swan, Laura Bouwman, Noelle Aarts, Leah Rosen, Gerrit Jan Hiddink, Maria Koelen
The biomedical model of health (BMH) studies the causes and origins of disease. When applied to nutrition research, eating is studied as a behavior that supports physical health. However, the lack of attention the BMH pays to social and historical circumstances in which health behaviors are constructed has been widely addressed in literature. When people are studied without considering contextual influences, the relevance to everyday life is limited. As a result, how individuals actively deal with their context to manage healthful eating is poorly understood...
October 4, 2017: Appetite
https://www.readbyqxmd.com/read/28986259/inhibition-of-constitutive-nf-%C3%AE%C2%BAb-activity-induces-platelet-apoptosis-via-er-stress
#7
Manoj Paul, Kempaiah Kemparaju, Kesturu S Girish
Platelets are anucleate cells, known for their pivotal roles in hemostasis, inflammation, immunity, and disease progression. Being anuclear, platelets are known to express several transcriptional factors which exert nongenomic functions, including the positive and negative regulation of platelet activation. NF-κB is one such transcriptional factor involved in the regulation of genes for survival, proliferation, inflammation and immunity. Although, the role NF-κB in platelet activation and aggregation is partially known, its function in management of platelet survival and apoptosis remain unexplored...
October 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28985025/multidisciplinary-approach-to-cardiac-and-pulmonary-vascular-disease-risk-assessment-in-liver-transplantation-an-evaluation-of-the-evidence-and-consensus-recommendations
#8
Lisa B VanWagner, Matthew E Harinstein, James R Runo, Christopher Darling, Marina Serper, Shelley Hall, Jon A Kobashigawa, Laura L Hammel
Liver transplant (LT) candidates today are older, have greater medical severity of illness, and have more cardiovascular comorbidities than ever before. In addition, there are specific cardiovascular responses in cirrhosis that can be detrimental to the LT candidate. Cirrhotic cardiomyopathy, a condition characterized by increased cardiac output and a reduced ventricular response to stress, is present in up to 30% of patients with cirrhosis thus challenging perioperative management. Current noninvasive tests that assess for subclinical coronary and myocardial disease have low sensitivity, and altered hemodynamics during the LT surgery can unmask latent cardiovascular disease either intraoperatively or in the immediate postoperative period...
October 6, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28979041/endothelial-glycocalyx-and-cardiopulmonary-bypass
#9
REVIEW
Gerard J Myers, Julie Wegner
On the outer surface of a human cell there is a dense layer of complex carbohydrates called glycocalyx, also referred to as glycans or the sugar coating on the cell surface, which is composed of a complex array of oligosaccharide and polysaccharide glucose chains that are covalently bonded to proteoglycans and lipids bound to the cell membrane surface. Studies of an intact endothelial glycocalyx layer (EGL) have revealed a number of critical functions that relate the importance of this protective layer to vascular integrity and permeability...
September 2017: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/28974953/poly-adp-ribose-polymerase-1-in-lung-inflammatory-disorders-a-review
#10
REVIEW
Gurupreet S Sethi, Vivek Dharwal, Amarjit S Naura
Asthma, acute lung injury (ALI), and chronic obstructive pulmonary disease (COPD) are lung inflammatory disorders with a common outcome, that is, difficulty in breathing. Corticosteroids, a class of potent anti-inflammatory drugs, have shown less success in the treatment/management of these disorders, particularly ALI and COPD; thus, alternative therapies are needed. Poly(ADP-ribose)polymerases (PARPs) are the post-translational modifying enzymes with a primary role in DNA repair. During the last two decades, several studies have reported the critical role played by PARPs in a good of inflammatory disorders...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28973481/arsenite-induces-vascular-endothelial-cell-dysfunction-by-activating-ire1%C3%AE-xbp1s-hif1%C3%AE-dependent-angii-signaling
#11
Xiuduan Xu, Shasha Liu, Qimuge Aodeng, Hongli Wang, Meiru Hu, Chen Xing, Lun Song
Chronic arsenic exposure is associated with the development of several cardiovascular (CV) diseases, including hypertension, carotid atherosclerosis and microvascular abnormalities. Upregulation of systemic and aortic angiotensin II (ANGII) signaling has been proposed to contribute to arsenic-induced vascular dysfunction. However, the underlying mechanisms of ANGII signaling augmentation and of the attendant pathological effects on the CV system induced by arsenic remain largely unknown. Here, we reported that exposure of human umbilical vein endothelial cells (HUVECs) to arsenite resulted in elevation of angiotensinogen (AGT, the precursor of ANGII), angiotensin-converting enzyme (ACE, the enzyme critical for ANGII generation) and ANGII type I receptor (AT1R) synthesis as well as increased ANGII production...
September 4, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28973008/effects-of-biotic-and-abiotic-factors-on-resistance-versus-resilience-of-douglas-fir-to-drought
#12
Gunnar Carnwath, Cara Nelson
Significant increases in tree mortality due to drought-induced physiological stress have been documented worldwide. This trend is likely to continue with increased frequency and severity of extreme drought events in the future. Therefore, understanding the factors that influence variability in drought responses among trees will be critical to predicting ecosystem responses to climate change and developing effective management actions. In this study, we used hierarchical mixed-effects models to analyze drought responses of Pseudotsuga menziesii in 20 unmanaged forests stands across a broad range of environmental conditions in northeastern Washington, USA...
2017: PloS One
https://www.readbyqxmd.com/read/28972997/egg-white-hydrolysate-shows-insulin-mimetic-and-sensitizing-effects-in-3t3-f442a-pre-adipocytes
#13
Forough Jahandideh, Subhadeep Chakrabarti, Sandra T Davidge, Jianping Wu
Insulin resistance and inflammation in adipose tissue is a key mechanism underlying metabolic syndrome, a growing health problem characterized by diabetes, obesity and hypertension. Previous work from our research group has demonstrated the potential of egg white ovotransferrin derived bioactive peptides against hypertension, oxidative stress and inflammation in vitro and in vivo. Egg white hydrolysate (EWH) has also shown anti-hypertensive effects in spontaneously hypertensive rats. Given the interplay among hypertension, inflammation, oxidative stress and metabolic syndrome, the objective of the study was to test the EWH on differentiation, insulin signaling and inflammatory responses in 3T3-F442A pre-adipocytes...
2017: PloS One
https://www.readbyqxmd.com/read/28971306/care-coordination-and-provider-stress-in-primary-care-management-of-high-risk-patients
#14
Adeyemi Okunogbe, Lisa S Meredith, Evelyn T Chang, Alissa Simon, Susan E Stockdale, Lisa V Rubenstein
BACKGROUND: Care coordination is a critical component of managing high-risk patients, who tend to have complex and multiple medical and psychosocial problems and are typically at high risk for increased hospitalization and incur high health care expenditures. Primary care models such as the patient-centered medical homes (PCMHs) are designed to improve care coordination and reduce care fragmentation. However, little is known about how the burden of care coordination for high-risk patients influences PCMH team members' stress...
October 2, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28965157/the-effect-of-listening-to-holy-quran-recitation-on-weaning-patients-receiving-mechanical-ventilation-in-the-intensive-care-unit-a-pilot-study
#15
Mohammad Yadak, Khalid Aziz Ansari, Hatem Qutub, Hajed Al-Otaibi, Omar Al-Omar, Nawal Al-Onizi, Faraz Ahmed Farooqi
Mechanical ventilation (MV) causes high level of stress in hospitalized patients. Weaning is the gradual process of decreasing ventilator support that in turn lead to termination of MV and increased respiratory effort, which may exacerbate symptoms and prolong MV. This study aimed to investigate the effect of listening to Holy Quran recitation (HQR) as a non-pharmacological intervention in patients during weaning from mechanical ventilation. This is a randomized controlled trial in which 55 patients admitted in the intensive care unit (ICU) and on mechanical ventilation were recruited...
September 30, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/28961516/the-role-of-biomechanics-in-aortic-aneurysm-management-requirements-open-problems-and-future-prospects
#16
REVIEW
Dario Farotto, Patrick Segers, Bart Meuris, Jos Vander Sloten, Nele Famaey
Wall stress estimation through biomechanical simulations represents a promising tool to support aneurysm risk stratification and has the potential to provide a more individual risk assessment. Accurate computation of the stress field necessitates the use of robust and biofidelic models based on patient-specific information. A multidisciplinary approach is required to obtain this information, which comprises geometry, boundary conditions, and material properties. The entire workflow encompasses many aspects, ranging from data collection to clinical interpretation of the obtained biomarkers...
August 18, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28951067/the-role-of-health-volunteers-in-training-women-regarding-coping-strategies-using-self-efficacy-theory-barriers-and-challenges-faced-by-health-volunteers-in-empowerment-of-women
#17
Mohammad Hossein Kaveh, Moslem Rokhbin, Arash Mani, Ahmad Maghsoudi
Introduction: Psychological distress is among physical and mental health threats, and health volunteers can play a critical role in empowerment of women. However, evidence has revealed a decline in health volunteers’ activities. Therefore, the present study aimed to investigate the challenges faced by health volunteers in empowerment of women. Methods: The participants’ knowledge level was assessed using a written test. Their perceived skills were also measured using Coping Inventory for Stressful Situations by Endler and Parker and Chesney’s Coping Self-efficacy Scale, respectively...
September 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28939950/anatomy-of-autophagy-from-the-beginning-to-the-end
#18
REVIEW
Xiaoyong Zhi, Wenzhi Feng, Yueguang Rong, Rong Liu
Autophagy is a highly regulated process in eukaryotes to maintain homeostasis and manage stress responses. Understanding the regulatory mechanisms and key players involved in autophagy will provide critical insights into disease-related pathogenesis and potential clinical treatments. In this review, we describe the hallmark events involved in autophagy, from its initiation, to the final destruction of engulfed targets. Furthermore, based on structural and biochemical data, we evaluate the roles of key players in these processes and provide rationale as to how they control autophagic events in a highly ordered manner...
September 22, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28933807/recognizing-and-managing-adrenal-disorders-in-the-emergency-department-digest
#19
Amy Cutright, Stephen Ducey, Claudia L Barthold, Jeremy Kim
Primary and secondary adrenal insufficiency are underrecognized conditions among emergency department patients, affecting an estimated 10% to 20% of critically ill patients. The signs and symptoms of cortisol deficit can be nonspecific and wide-ranging, and identification and swift treatment with stress-dosing of hydrocortisone is vital to avoid life-threatening adrenal crisis. Laboratory evaluation focuses on identification of electrolyte abnormalities typical of adrenal insufficiency, and while additional testing may depend on the type and severity of symptoms, it should not delay corticosteroid replacement...
September 22, 2017: Emergency Medicine Practice
https://www.readbyqxmd.com/read/28926391/medical-team-training-improves-team-performance-aoa-critical-issues
#20
James E Carpenter, James P Bagian, Rebecca G Snider, Kyle J Jeray
Effective teamwork and communication can decrease medical errors in environments where the culture of safety is enhanced. Health care can benefit from programs that are based on teamwork, as in other high-stress industries (e.g., aviation), with crew resource management programs, simulator use, and utilization of checklists. Medical team training (MTT) with a strong leadership commitment was used at our institution to focus specifically on creating open, yet structured, communication in operating rooms. Training included the 3 phases of the World Health Organization protocol to organize communication and briefings: preoperative verification, preincision briefing, and debriefing at or near the end of the surgical case...
September 20, 2017: Journal of Bone and Joint Surgery. American Volume
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