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Critical stress management

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https://www.readbyqxmd.com/read/28286784/the-influence-of-metabolic-imbalances-and-oxidative-stress-on-the-outcome-of-critically-ill-polytrauma-patients-a-review
#1
REVIEW
Alexandru Florin Rogobete, Dorel Sandesc, Marius Papurica, Emil Robert Stoicescu, Sonia Elena Popovici, Lavinia Melania Bratu, Corina Vernic, Adriana Mariana Sas, Adrian Tudor Stan, Ovidiu Horea Bedreag
The critically ill polytrauma patient presents with a series of associated pathophysiologies secondary to the traumatic injuries. The most important include systemic inflammatory response syndrome (SIRS), sepsis, oxidative stress (OS), metabolic disorders, and finally multiple organ dysfunction syndrome (MODS) and death. The poor outcome of these patients is related to the association of the aforementioned pathologies. The nutrition of the critically ill polytrauma patient is a distinct challenge because of the rapid changes in terms of energetic needs associated with hypermetabolism, sepsis, SIRS, and OS...
2017: Burns and trauma
https://www.readbyqxmd.com/read/28280912/identifying-critical-habitat-for-australian-freshwater-turtles-in-a-large-regulated-floodplain-implications-for-environmental-water-management
#2
J F Ocock, G Bino, S Wassens, J Spencer, R F Thomas, R T Kingsford
Freshwater turtles face many threats, including habitat loss and river regulation reducing occupancy and contributing to population decline. Limited knowledge of hydrological conditions required to maintain viable turtle populations in large floodplain wetlands hinders effective adaptive management of environmental water in regulated rivers. We surveyed three turtle species over 4 years across the Lower Murrumbidgee River floodplain, a large wetland complex with a long history of water resource development...
March 9, 2017: Environmental Management
https://www.readbyqxmd.com/read/28279415/proteasome-inhibitors-as-a-potential-cause-of-heart-failure
#3
REVIEW
Georgios Koulaouzidis, Alexander R Lyon
Proteasome inhibitors have become an important drug class in the treatment of multiple myeloma. In addition to its role in myeloma cells, the proteasome plays a critical role in the myocardium, particularly in the context of cardiac stress. The growing awareness of the cardiovascular toxicity of proteasome inhibitors is emerging following the phase 3 trials and the transition into real-world practice. This article reviews the background to this problem and the incidence of the problem in phase 3 trials and subsequent phase 2 trials in new patient cohorts and discusses the strategy to detect and manage this emerging problem...
April 2017: Heart Failure Clinics
https://www.readbyqxmd.com/read/28274956/natriuretic-peptides-in-the-evaluation-and-management-of-degenerative-mitral-regurgitation-a-systematic-review
#4
REVIEW
Michael M Johl, Pankaj Malhotra, Devin W Kehl, Florian Rader, Robert J Siegel
Progression of degenerative mitral regurgitation (MR) leads to irreversible cardiac damage. Therefore, longitudinal follow up to determine the optimal timing of surgery is critical. Current data indicates that in addition to the standard of care-assessing for symptoms and signs of left ventricular (LV) decompensation with routine echocardiography-serial measurement of natriuretic peptides offers a quantitative means to identify patients who may benefit from closer supervision, if not surgery. Natriuretic peptide levels, and specifically changes from baseline, identify both symptomatic patients and others likely to develop cardiac dysfunction...
March 8, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28271917/what-can-medical-educators-learn-from-the-rio-2016-olympic-games
#5
Helen Church, Deborah Murdoch-Eaton, Rakesh Patel, John Sandars
Medical Educators face an ongoing challenge in optimizing preparedness for practice for newly qualified doctors. Junior doctors have highlighted specific areas in which they do not feel adequately equipped to undertake their duties, including managing the acutely unwell patient. In these highly stressful, time-critical scenarios it might be assumed that a lack of knowledge underpins these feelings of apprehension from junior medics; however, having studied, trained and passed examinations to demonstrate such knowledge, perhaps other factors should be considered...
February 28, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28264720/improving-and-sustaining-delivery-of-cpt-for-ptsd-in-mental-health-systems-a-cluster-randomized-trial
#6
Shannon Wiltsey Stirman, Erin P Finley, Norman Shields, Joan Cook, Rachel Haine-Schlagel, James F Burgess, Linda Dimeff, Kelly Koerner, Michael Suvak, Cassidy A Gutner, David Gagnon, Tasoula Masina, Matthew Beristianos, Kera Mallard, Vanessa Ramirez, Candice Monson
BACKGROUND: Large-scale implementation of evidence-based psychotherapies (EBPs) such as cognitive processing therapy (CPT) for posttraumatic stress disorder can have a tremendous impact on mental and physical health, healthcare utilization, and quality of life. While many mental health systems (MHS) have invested heavily in programs to implement EBPs, few eligible patients receive EBPs in routine care settings, and clinicians do not appear to deliver the full treatment protocol to many of their patients...
March 6, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28247459/shifting-paradigms-in-restoration-of-the-world-s-coral-reefs
#7
Madeleine J H van Oppen, Ruth D Gates, Linda L Blackall, Neal Cantin, Leela J Chakravarti, Wing Y Chan, Craig Cormick, Angela Crean, Katarina Damjanovic, Hannah Epstein, Peter L Harrison, Thomas A Jones, Margaret Miller, Rachel J Pears, Lesa M Peplow, David A Raftos, Britta Schaffelke, Kristen Stewart, Gergely Torda, David Wachenfeld, Andrew R Weeks, Hollie M Putnam
Many ecosystems around the world are rapidly deteriorating due to both local and global pressures, and perhaps none so precipitously as coral reefs. Management of coral reefs through maintenance (e.g., marine-protected areas, catchment management to improve water quality), restoration, as well as global and national governmental agreements to reduce greenhouse gas emissions (e.g., the 2015 Paris Agreement) is critical for the persistence of coral reefs. Despite these initiatives, the health and abundance of corals reefs are rapidly declining and other solutions will soon be required...
March 1, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28244581/work-related-stress-and-blood-glucose-levels
#8
A Sancini, S Ricci, F Tomei, C Sacco, A Pacchiarotti, N Nardone, P Ricci, A Suppi, D P De Cesare, V Anzelmo, R Giubilati, B Pimpinella, M V Rosati, G Tomei
AIM: The aim of the study is to evaluate work-related subjective stress in a group of workers on a major Italian company in the field of healthcare through the administration of a valid "questionnaire-tool indicator" (HSE Indicator Tool), and to analyze any correlation between stress levels taken from questionnaire scores and blood glucose values. MATERIAL AND METHODS: We studied a final sample consisting of 241 subjects with different tasks. The HSE questionnaire - made up of 35 items (divided into 7 organizational dimensions) with 5 possible answers - has been distributed to all the subjects in occasion of the health surveillance examinations provided by law...
March 2017: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/28243070/improving-adherence-and-outcomes-in-diabetic-patients
#9
Renu Joshi, Disha Joshi, Pramil Cheriyath
OBJECTIVE: Nonadherence in diabetes is a problem leading to wasted resources and preventable deaths each year. Remedies for diminishing nonadherence are many but marginally effective, and outcomes remain suboptimal. AIM: The aim of this study was to test a new iOS "app", PatientPartner. Derived from complexity theory, this novel technology has been extensively used in other fields; this is the first trial in a patient population. METHODS: Physicians referred patients who were "severely non-adherent" with HbA1c levels >8...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28224109/timing-method-and-discontinuation-of-hydrocortisone-administration-for-septic-shock-patients
#10
Miguel A Ibarra-Estrada, Quetzalcóatl Chávez-Peña, Claudia I Reynoso-Estrella, Jorge Rios-Zermeño, Pável E Aguilera-González, Miguel A García-Soto, Guadalupe Aguirre-Avalos
AIM: To characterize the prescribing patterns for hydrocortisone for patients with septic shock and perform an exploratory analysis in order to identify the variables associated with better outcomes. METHODS: This prospective cohort study included 59 patients with septic shock who received stress-dose hydrocortisone. It was performed at 2 critical care units in academic hospitals from June 1(st), 2015, to July 31(st), 2016. Demographic data, comorbidities, medical management details, adverse effects related to corticosteroids, and outcomes were collected after the critical care physician indicated initiation of hydrocortisone...
February 4, 2017: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28183438/cardiac-imaging-for-assessing-low-gradient-severe-aortic-stenosis
#11
REVIEW
Marie-Annick Clavel, Ian G Burwash, Philippe Pibarot
Up to 40% of patients with aortic stenosis (AS) harbor discordant Doppler-echocardiographic findings, the most common of which is the presence of a small aortic valve area (≤1.0 cm(2)) suggesting severe AS, but a low gradient (<40 mm Hg) suggesting nonsevere AS. The purpose of this paper is to present the role of multimodality imaging in the diagnostic and therapeutic management of this challenging entity referred to as low-gradient AS. Doppler-echocardiography is critical to determine the subtype of low-gradient AS: that is, classical low-flow, paradoxical low-flow, or normal-flow...
February 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28183072/alternative-therapies-for-excoriation-skin-picking-disorder-a-brief-update
#12
REVIEW
Julio Torales, Iván Barrios, Jorge Villalba
Context • Excoriation (skin picking) disorder is characterized by the need or urge to pick, scratch, pinch, touch, rub, scrub, squeeze, bite, or dig the skin, and it can be a perplexing condition for the inexperienced physician. Treatments include pharmacotherapy, psychotherapy, and alternative therapies. Alternative therapies for excoriation disorder and other body-focused repetitive behaviors include yoga, aerobic exercise, acupuncture, biofeedback, hypnosis, and inositol and N-acetylcysteine, among others...
January 2017: Advances in Mind-body Medicine
https://www.readbyqxmd.com/read/28178022/the-impact-of-essential-fatty-acid-b-vitamins-vitamin-c-magnesium-and-zinc-supplementation-on-stress-levels-in-women-a-systematic-review
#13
Delia McCabe, Karolina Lisy, Craig Lockwood, Marc Colbeck
BACKGROUND: Women juggling multiple roles in our complex society are increasingly experiencing psychological stress. Dietary supplementation to manage stress is widespread despite limited supporting evidence. A systematic review of the available literature was undertaken to investigate the efficacy of specific dietary supplements in managing female stress and anxiety. OBJECTIVES: To identify the impact of essential fatty acids (EFAs), B vitamins, vitamin C, magnesium and/or zinc, consumed as dietary supplements to the daily diet, on female stress and anxiety levels...
February 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28168021/refuge-or-predation-risk-alternate-ways-to-perceive-hiker-disturbance-based-on-maternal-state-of-female-caribou
#14
Frédéric Lesmerises, Chris J Johnson, Martin-Hugues St-Laurent
Human presence in natural environments is often a source of stress that is perceived by large ungulates as an increased risk of predation. Alternatively, disturbance induced by hikers creates a relatively predator-free space that may serve as a refuge. We measured the behavioral responses of female caribou to disturbance associated with the presence of hikers during summer in the Gaspésie National Park. We used those data to determine whether caribou responded negatively to human activity (i.e., the predation risk hypothesis) or whether human activity resulted in a decrease in the magnitude of perceived risk (i...
February 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28164521/using-the-expression-of-damage-associated-molecular-pattern-damp-for-the-evaluation-and-monitoring-of-the-critically-ill-polytrauma-patient
#15
REVIEW
Marius Papurica, Alexandru F Rogobete, Dorel Sandesc, Carmen A Cradigati, Mirela Sarandan, Raluca Dumache, Florin G Horhat, Lavinia M Bratu, Razvan Nitu, Dan C Crisan, Delia I Horhat, Elena S Popovici, Sonia Tanasescu, Vlad Daliborca, Ovidiu Boruga, Ovidiu H Bedreag
BACKGROUND: The critically ill polytrauma patient continues to be one of the most complex cases in the intensive care unit (ICU). The molecular damage is closely connected with the severe, specific pathophysiological imbalances, such as severe inflammation, infections, hypermetabolism, oxidative stress, and ultimately multiple organ dysfunction syndrome (MODS). METHODS: The literature available on PubMed and Scopus was analysed for this study. The key words used in the search were "biomarkers in critically ill patients", "molecular damage", "sepsis biomarkers", "miRNAs biomarkers", and "oxidative stress"...
October 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28159664/young-adults-use-of-emotional-food-memories-to-build-resilience
#16
Elisabeth von Essen, Fredrika Mårtensson
The overall aim of this study is to specifically investigate how young adults make use of emotional-relational food memories related to "significant others" during childhood when trying to build resilience and solve developmental tasks in this period of life. A theoretical sample of three semi-structured interviews drawn from a larger sample of 30 interviews with young adults in Sweden formed the basis for analysis, guided by the steps of a phenomenologically oriented critical narrative analysis. The results illustrate three different overall directions in how the relationship to food can evolve throughout life among young adults: a relationship dominated by 1) positive emotional food memories associated with the use of food as a secure base and 2) negative emotional food memories associated with either a) being emotionally preoccupied with food or b) dismissing food...
January 31, 2017: Appetite
https://www.readbyqxmd.com/read/28144160/association-between-lymphocyte-expression-of-the-apoptotic-receptor-fas-and-pain-in-critically-ill-patients
#17
Elizabeth DE Papathanassoglou, Meropi DA Mpouzika, Margarita Giannakopoulou, Evangelos Bozas, Nicos Middleton, George Tsiaousis, Andreas Karabinis
OBJECTIVE: Lymphocyte apoptosis in critical illness is associated with immunosuppression. We explored for the first time the associations between pain ratings and expression of the apoptotic receptor Fas on B and T cells in critically ill patients and the potential mediating effects of adrenocorticotropic hormone (ACTH), cortisol, and substance P (SP). DESIGN: This is an exploratory correlational study with repeated measurements (14 days followup) and cross-sectional comparisons...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28125983/fathers-views-and-experiences-of-their-own-mental-health-during-pregnancy-and-the-first-postnatal-year-a-qualitative-interview-study-of-men-participating-in-the-uk-born-and-bred-in-yorkshire-baby-cohort
#18
Z Darwin, P Galdas, S Hinchliff, E Littlewood, D McMillan, L McGowan, S Gilbody
BACKGROUND: The prevalence of fathers' depression and anxiety in the perinatal period (i.e. from conception to 1 year after birth) is approximately 5-10%, and 5-15%, respectively; their children face increased risk of adverse emotional and behavioural outcomes, independent of maternal mental health. Critically, fathers can be protective against the development of maternal perinatal mental health problems and their effects on child outcomes. Preventing and treating paternal mental health problems and promoting paternal psychological wellbeing may therefore benefit the family as a whole...
January 26, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28116619/hdac6-regulates-sensitivity-to-cell-death-in-response-to-stress-and-post-stress-recovery
#19
Hyun-Wook Ryu, Hye-Rim Won, Dong Hoon Lee, So Hee Kwon
Histone deacetylase 6 (HDAC6) plays an important role in stress responses such as misfolded protein-induced aggresomes, autophagy, and stress granules. However, precisely how HDAC6 manages response during and after cellular stress remains largely unknown. This study aimed to investigate the effect of HDAC6 on various stress and post-stress recovery responses. We showed that HIF-1α protein levels were reduced in HDAC6 knockout (KO) MEFs compared to wild-type (WT) MEFs in hypoxia. Furthermore, under hypoxia, HIF-1α levels were also reduced following rescue with either a catalytically inactive or a ubiqiutin-binding mutant HDAC6...
January 23, 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/28115381/adaptive-evolution-of-extreme-acidophile-sulfobacillus-thermosulfidooxidans-potentially-driven-by-horizontal-gene-transfer-and-gene-loss
#20
Xian Zhang, Xueduan Liu, Yili Liang, Xue Guo, Yunhua Xiao, Liyuan Ma, Bo Miao, Hongwei Liu, Deliang Peng, Wenkun Huang, Yuguang Zhang, Huaqun Yin
Recent phylogenomic analysis has suggested that three strains isolated from different copper mine tailings around the world were taxonomically affiliated with Sulfobacillus thermosulfidooxidans Here, we present a detailed investigation of their genomic features, particularly with respect to metabolic potentials and stress tolerance mechanisms. Comprehensive analysis of the Sulfobacillus genomes identified a core set of essential genes with specialized biological functions in the survival of acidophiles in their habitats, despite differences in their metabolic pathways...
January 23, 2017: Applied and Environmental Microbiology
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