keyword
https://read.qxmd.com/read/38534512/the-effect-of-mechanical-circulatory-support-on-blood-flow-in-the-ascending-aorta-a-combined-experimental-and-computational-study
#1
JOURNAL ARTICLE
Sapir Hazan Shenberger, Idit Avrahami
Percutaneous mechanical circulatory support (MCS) devices are designed for short-term treatment in cases of acute decompensated heart failure as a bridge to transplant or recovery. Some of the known complications of MCS treatments are related to their hemodynamics in the aorta. The current study investigates the effect of MCS on the aortic flow. The study uses combined experimental and numerical methods to delineate complex flow structures. Particle image velocimetry (PIV) is used to capture the vortical and turbulent flow characteristics in a glass model of the human aorta...
February 28, 2024: Bioengineering
https://read.qxmd.com/read/38531697/modified-screening-and-management-strategies-for-chronic-rhinosinusitis-in-hematologic-patients-receiving-hematopoietic-stem-cell-transplantation
#2
JOURNAL ARTICLE
Yen-Hui Lee, Chih-Feng Lin, Te-Huei Yeh, Huai-Hsuan Huang, Yi-Tsen Lin
OBJECTIVES: Given the lack of consensus on the screening and treatment for chronic rhinosinusitis (CRS) in the patients undergoing hematopoietic stem cell transplantation (HSCT), we reviewed the risk factors for CRS to improve the efficiency of sinonasal screening and analyzed the effect of treating CRS in search of guidance for modifying current management strategies for rhinosinusitis in HSCT patients. METHODS: We conducted a nested case-control study in a retrospective cohort of hematologic patients receiving HSCT from April 2011 to April 2021 and collected data on demographics, smoking/atopic status, hematological diseases, and features of rhinosinusitis for analysis...
March 25, 2024: Journal of the Formosan Medical Association
https://read.qxmd.com/read/38527841/-single-non-blood-related-umbilical-cord-blood-transplantation-using-a-reduced-intensity-conditioning-regimen-for-the-treatment-of-severe-aplastic-anemia
#3
JOURNAL ARTICLE
Y Wu, B L Tang, K D Song, G Y Sun, T Z Pan, A J Huang, B B Yan, X Y Zhu
Objective: To evaluated the clinical efficacy of a reduced-intensity preconditioning regimen for single non-blood-related umbilical cord blood transplantation (sUCBT) in the treatment of severe aplastic anemia (SAA) . Methods: The clinical data of 63 patients with SAA who underwent sUCBT from January 2021 to July 2023 at the Department of Hematology of the First Affiliated Hospital of USTC were retrospectively analyzed. Fifty-two patients received total body irradiation/total bone marrow irradiation (TMI) combined with fludarabine or a cyclophosphamide- conditioning regimen (non-rATG group) , while 11 patients received rabbit anti-human thymocyte immunoglobulin (rATG) combined with TMI, fludarabine, or the cyclophosphamide-conditioning regimen (rATG group) ...
January 14, 2024: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://read.qxmd.com/read/38526652/covid-19-associated-secondary-sclerosing-cholangitis-with-liver-transplantation
#4
JOURNAL ARTICLE
Anne Kristin Fischer, Dirk Stippel, Ali Canbay, Dirk Nierhoff, Michael Thomas, Jan Best, Reinhard Büttner, Uta Drebber
We report on two cases of orthotopic liver transplantation (OLTX) due to SARS-Cov2-associated secondary sclerosing cholangitis (SSC) following long-term artificial respiration and extra-corporal membrane oxygenation in intensive care. Under these conditions, SSC is a rapidly progredient biliary disease featuring degenerative cholangiopathy, loss of bile ducts, ductular and parenchymal cholestasis, biliary fibrosis, and finally cirrhosis. Reduced perfusion and oxygenation of the peribiliary plexus, severe concurrent infections, and secondary medico-toxic effects appear to play a crucial role in the pathogenesis of the disease...
March 25, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38516468/recurrent-acute-upper-gastrointestinal-bleed-due-to-diffuse-b-cell-lymphoma-of-the-duodenum-in-a-renal-transplant-patient-a-case-report-and-literature-review
#5
Michael Ladna, John George, Christopher E Forsmark
A patient status post (s/p) renal transplantation in 2014 presented with an upper gastrointestinal bleed (UGIB). The source of the bleed was found to be a large mass in the duodenum with histopathology from biopsies obtained during esophagogastroduodenoscopy revealing diffuse large B-cell lymphoma (DLBCL) of the duodenum. His mycophenolate was stopped, and the tacrolimus dose was reduced due to active malignancy. He was discharged and completed one cycle of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) before presenting back to ED with hemorrhagic shock from a large upper GI bleed requiring admission to the medical intensive care unit...
February 2024: Curēus
https://read.qxmd.com/read/38516258/nature-based-virtual-reality-intervention-to-manage-stress-in-family-caregivers-of-allogeneic-hematopoietic-stem-cell-transplant-recipients-a-two-phase-pilot-study-protocol
#6
JOURNAL ARTICLE
Lena J Lee, Elisa H Son, Nicole Farmer, Chantal Gerrard, Ralph Thadeus Tuason, Li Yang, Julie Kohn-Godbout, Cory Stephens, Eun-Shim Nahm, Leslie Smith, Steve Risch, Gwenyth R Wallen
UNLABELLED: Millions of family members and/or friends in the U.S. serve as unpaid caregivers for individuals with chronic conditions, such as cancer. Caregiving for someone undergoing an intense allogeneic hematopoietic stem cell transplant (HSCT) is particularly demanding, with accompanying physical and psychological stress. Increased stress and stress-related symptoms could make it difficult for caregivers to fulfill their roles and could negatively impact the health status and quality of life of themselves and the recipients...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38515576/photodynamic-therapy-with-paclitaxel-encapsulated-indocyanine-green-modified-liposomes-for-breast-cancer
#7
JOURNAL ARTICLE
Mariko Ishizuka, Masaki Kaibori, Fusao Sumiyama, Yoshiharu Okamoto, Akiko Suganami, Yutaka Tamura, Kengo Yoshii, Tomoharu Sugie, Mitsugu Sekimoto
BACKGROUND: Photodynamic therapy (PDT) involves the administration of a photosensitizing agent and irradiation of light at an excitation wavelength that damages tumor cells without causing significant damage to normal tissue. We developed indocyanine green (ICG)-modified liposomes in which paclitaxel (PTX) was encapsulated (ICG-Lipo-PTX). ICG-Lipo-PTX accumulates specifically in tumors due to the characteristics of the liposomes. The thermal and photodynamic effects of ICG and the local release of PTX by irradiation are expected to induce not only antitumor effects but also cancer immunity...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38514166/gestational-alloimmune-liver-disease-with-alpha-thalassaemia-in-a-neonate
#8
JOURNAL ARTICLE
Nishant Banait, Sai Vamshi Varanasi, Abinash Nayak, Kushal Talukder
A term baby presented with cholestatic jaundice since birth. She was diagnosed as gestational alloimmune liver disease-neonatal haemochromatosis (GALD-NH) on evaluation. The baby received intravenous immunoglobulin (IVIG) and recovered gradually from the illness. She was also diagnosed with alpha thalassaemia during the course of evaluation, confirmed by genetic testing. NH is a very rare disorder that results in fetal loss or neonatal death due to liver failure. NH is now known to be a phenotypic expression of GALD...
March 21, 2024: BMJ Case Reports
https://read.qxmd.com/read/38511645/current-status-of-conditioning-regimens-in-haploidentical-hematopoietic-cell-transplantation
#9
REVIEW
Junichi Sugita, Masamitsu Yanada
The development of effective prophylaxis strategies against graft-versus-host disease (GVHD) has contributed to the widespread use of haploidentical related hematopoietic cell transplantation (Haplo-HCT). Currently, GVHD prophylaxis containing posttransplant cyclophosphamide (PTCY) is considered the standard of care in Haplo-HCT, and recent studies have shown comparable results for PTCY-based Haplo-HCT and HCT from other donor sources. The conditioning regimen plays an important role in eradicating tumor cells to prevent disease relapse and suppressing the recipient's immune system to facilitate engraftment...
December 2024: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/38504697/pretreated-mscs-with-ironq-transplantation-attenuate-microglia-neuroinflammation-via-the-cgas-sting-signaling-pathway
#10
JOURNAL ARTICLE
Guoqiang Yang, Jiraporn Kantapan, Maryam Mazhar, Qiongdan Hu, Xue Bai, Yuanxia Zou, Honglian Wang, Sijin Yang, Li Wang, Nathupakorn Dechsupa
BACKGROUND: Intracerebral hemorrhage (ICH), a devastating form of stroke, is characterized by elevated morbidity and mortality rates. Neuroinflammation is a common occurrence following ICH. Mesenchymal stem cells (MSCs) have exhibited potential in treating brain diseases due to their anti-inflammatory properties. However, the therapeutic efficacy of MSCs is limited by the intense inflammatory response at the transplantation site in ICH. Hence, enhancing the function of transplanted MSCs holds considerable promise as a therapeutic strategy for ICH...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38503942/allogeneic-hematopoietic-stem-cell-transplantation-for-patients-with-richter-transformation-a-retrospective-study-on-behalf-of-the-chronic-malignancies-working-party-of-the-ebmt
#11
JOURNAL ARTICLE
Romain Guièze, Diderik-Jan Eikema, Linda Koster, Johannes Schetelig, Henrik Sengeloev, Jakob Passweg, Jürgen Finke, Mutlu Arat, Annoek E C Broers, Friedrich Stölzel, Jenny Byrne, Cristina Castilla-Llorente, Peter Dreger, Matthias Eder, Tobias Gedde-Dahl, Nicolaus Kröger, Josep Maria Ribera Santasusana, Deborah Richardson, Alessandro Rambaldi, Lucrecia Yañez, Michel Van Gelder, Joanna Drozd-Sokolowska, Kavita Raj, Ibrahim Yakoub-Agha, Olivier Tournilhac, Donal P McLornan
Management of Richter transformation (RT) is particularly challenging, with survival estimates <1 year. We report on outcomes of 66 RT patients undergoing allogeneic-HCT (allo-HCT) between 2008 and 2018 registered with the EBMT. Median age at allo-HCT was 56.2 years (interquartile range (IQR), 51.3-63.1). Median time from RT to allo-HCT was 6.9 months (IQR, 4.9-11) and 28 (42.4%) were in complete remission (CR). The majority underwent reduced intensity conditioning (66.2%) using peripheral blood derived stem cells...
March 19, 2024: Bone Marrow Transplantation
https://read.qxmd.com/read/38503525/-daratumumab-maintenance-after-autologous-hematopoietic-stem-cell-transplantation-for-newly-diagnosed-multiple-myeloma
#12
JOURNAL ARTICLE
Y Ma, X B Xiao, X L Chen, S Z Yuan, Y Lu, S H Zhao, J L Chen, G N Shi, Y Q Wang, N N Cheng, P Feng, M S Ding, W R Huang
Objective: This study aimed to evaluate the efficacy and safety of daratumumab as a maintenance treatment after autologous hematopoietic stem cell transplantation (auto-HSCT) in patients with newly diagnosed multiple myeloma (NDMM) . Methods: The clinical data, hematological and renal response, and safety of 15 post-transplant patients with NDMM who had received daratumumab maintenance between May 1, 2022 and June 30, 2023 were retrospectively analyzed. Results: Fifteen patients (11 males and 4 females) with a median age of 58 (41-72) years were included...
December 14, 2023: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://read.qxmd.com/read/38494399/the-use-of-a-high-flow-picc-catheter-for-stem-cell-and-lymphocyte-apheresis-the-initial-experience-of-a-pediatric-oncology-center-in-brazil
#13
JOURNAL ARTICLE
Vilani Kremer, Andréia Rheinheimer, Ana Luiza Rodrigues, Andressa Taborda, Robson Coelho, Antonella Zanette
BACKGROUND: Autologous hematopoietic stem cell transplant (HSCT), characterized by high intensity chemotherapy followed by the infusion of HSC previously collected from the peripheral blood, is a procedure used in the treatment of several malignancies. In pediatrics, the apheresis procedure represents a challenge, due to the need for insertion of a rigid central venous catheter (CVC) in small children. The CVC is usually used for stem cell collection and then removed. Later, the patient will need a new device for cell infusion...
February 24, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38476903/risk-factors-and-predictive-model-for-mortality-in-patients-undergoing-allogeneic-hematopoietic-stem-cell-transplantation-admitted-to-the-intensive-care-unit
#14
JOURNAL ARTICLE
Peihua Wu, Wenxuan Huo, Huiying Zhao, Jie Lv, Shan Lv, Youzhong An
Hematological malignant tumors represent a group of major diseases carrying a substantial risk to the lives of affected patients. Risk factors for mortality in critically ill patients have garnered substantial attention in recent research endeavors. The present research aimed to identify factors predicting intensive care unit (ICU) mortality in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Furthermore, the present study analyzed and compared the mortality rate between patients undergoing haploidentical hematopoietic stem cell transplantation (Haplo-SCT) and those undergoing identical sibling donor (ISD) transplantation...
April 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38462360/-effect-of-sirolimus-combined-with-anti-cd20-monoclonal-antibody-desensitization-on-the-prognosis-of-patients-underwent-haploidentical-stem-cell-transplantation
#15
JOURNAL ARTICLE
N Ma, Z D Wang, Y Q Sun, C H Yan, F R Wang, X D Mo, M Lyu, X Y Zhao, X S Zhao, W Han, H Chen, Y Y Chen, Y Wang, L P Xu, Y F Cheng, X H Zhang, K Y Liu, X J Huang, Y J Chang
Objective: To investigate the effects of sirolimus combined with anti-CD20 monoclonal antibody desensitization on the prognosis of patients with haploidentical stem cell transplantation (haplo-SCT). Methods: Fifteen consecutive patients who received haplo-SCT and pre-transplant donor specific anti-human leukocyte antigen (HLA) antibody (DSA) positive [mean fluorescence intensity (MFI)≥2 000] in the Institute of Hematological Diseases from November 2021 to March 2023 were retrospectively recruited into the desensitized group...
March 19, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38460729/phase-ii-study-of-allogeneic-hematopoietic-stem-cell-transplantation-for-children-with-high-risk-neuroblastoma-using-a-reduced-intensity-conditioning-regimen-results-from-the-aieop-trial
#16
JOURNAL ARTICLE
Arcangelo Prete, Edoardo Lanino, Francesco Saglio, Alessandra Biffi, Elisabetta Calore, Maura Faraci, Roberto Rondelli, Claudio Favre, Marco Zecca, Gabriella Casazza, Fulvio Porta, Roberto Luksch, Simone Cesaro, Marco Rabusin, Rosanna Parasole, Rosa Maria Mura, Luca Lo Nigro, Davide Leardini, Daria Pagliara, Franco Locatelli, Franca Fagioli
Despite aggressive multimodal treatment, the outcome of pediatric patients affected by high-risk (HR) neuroblastoma (NB) remains poor. The rational of use of allogeneic hematopoietic stem cell transplantation (allo-HCT) for NB was based on the possible graft versus tumor effect; however, toxicity represents a limitation to its efficacy. We sought to prospectively assess the feasibility and efficacy of allo-HCT using a reduced intensity conditioning regimen in pediatric patients with HR NB in a multicenter phase II trial...
March 7, 2024: Transplantation and cellular therapy
https://read.qxmd.com/read/38460728/nutritional-strategies-to-improve-vre-control
#17
JOURNAL ARTICLE
Enrico Morello, Sara Roversi, Giulia Brambilla, Liana Signorini, Marianna Lorenzoni, Marco Andreoli, Simona Bernardi, Michele Malagola, Mirko Farina, Vera Radici, Gabriele Magliano, Simona Fiorentini, Arnaldo Caruso, Domenico Russo
The rise of Vancomycin-resistant enterococci (VRE) strains among cellular therapy recipients raises concerns due to increased morbidity, mortality, and hospitalization costs, particularly impacting transplanted patients with diminished survival expectations. Recent research linking lactose to Enterococcus growth and graft-versus-host disease (GVHD) emphasizes the need for data on reducing lactose in the diets of VRE-carrying patients, especially in cellular therapy contexts like CAR-T or allogeneic hematopoietic stem cell transplantation...
March 7, 2024: Transplantation and cellular therapy
https://read.qxmd.com/read/38452207/nilotinib-with-or-without-cytarabine-for-philadelphia-positive-acute-lymphoblastic-leukemia
#18
JOURNAL ARTICLE
Yves Chalandon, Philippe Rousselot, Sylvie Chevret, Jean-Michel Cayuela, Rathana Kim, Françoise Huguet, Patrice Chevallier, Carlos Graux, Anne Thiebaut-Bertrand, Sylvain P Chantepie, Xavier Thomas, Laure Vincent, Celine Berthon, Yosr Hicheri, Emmanuel Raffoux, Martine Escoffre-Barbe, Isabelle Plantier, Magalie Joris, Pascal Turlure, Florence Pasquier, Amine Belhabri, Gabrielle Roth Guepin, Sabine Blum, Michael Gregor, Marina Lafage-Pochitaloff, Julie Quessada, Veronique Lheritier, Emmanuelle Clappier, Nicolas Boissel, Hervé Dombret
We previously demonstrated that a reduced-intensity chemotherapy schedule can safely replace Hyper-CVAD cycle 1 when combined with imatinib in adults with Philadelphia-positive (Ph+) acute lymphoblastic leukemia (ALL). In the present randomized GRAAPH-2014 trial, we used nilotinib and addressed the omission of cytarabine (Ara-C) in consolidation. The primary objective was the major molecular response (MMR) rate measured by BCR::ABL1 quantification after cycle 4 (end of consolidation). All patients were eligible for allogeneic stem cell transplant (SCT), whereas those in MMR could receive autologous SCT, followed by 2-year imatinib maintenance in both cases...
March 7, 2024: Blood
https://read.qxmd.com/read/38448249/preoperative-intrathecal-morphine-is-associated-with-reduced-postoperative-pain-agitation-and-delirium-in-living-donor-kidney-transplantation-recipients
#19
JOURNAL ARTICLE
Ja Eun Lee, Kyo Won Lee, Eunmi Gil, Jae Berm Park, Byung Jun Kim, Ha Yeon Kim, Gaab-Soo Kim
BACKGROUND: Postoperative delirium after organ transplantation can lead to increased length of hospital stay and mortality. Because pain is an important risk factor for delirium, perioperative analgesia with intrathecal morphine (ITM) may mitigate postoperative delirium development. We evaluated if ITM reduces postoperative delirium incidence in living donor kidney transplant (LDKT) recipients. METHODS: Two hundred ninety-six patients who received LDKT between 2014 and 2018 at our hospital were retrospectively analyzed...
March 5, 2024: Transplantation Proceedings
https://read.qxmd.com/read/38448168/-pulmonary-artery-stenosis-after-single-lung-transplantation-a-case-report-and-literature-review
#20
REVIEW
Z M Fang, Y B Wang, Z D Ding, F K Li, K Zhao, G F Zhao
Objective: To summarize and analyze the clinical features, treatment, and prognosis of pulmonary artery stenosis post-lung transplantation. Methods: A 62-year-old male patient was admitted to the hospital with a cough and chest tightness of over a year's duration, which had worsened in the last two months, leading to the diagnosis of idiopathic pulmonary fibrosis. The clinical data were observed and reviewed post-left allograft single lung transplantation. Literature searches were conducted using the keywords "lung transplantation" "stenosis, pulmonary artery" and "postoperative complications" in CNKI, Wanfang Medical Network, and PubMed databases up to December 2022...
March 12, 2024: Chinese Journal of Tuberculosis and Respiratory Diseases
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