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https://www.readbyqxmd.com/read/29761372/outcomes-of-takotsubo-cardiomyopathy-in-hospitalized-cancer-patients
#1
Parijat Saurav Joy, Achuta Kumar Guddati, Iuliana Shapira
BACKGROUND: Chemotherapy-induced cardiomyopathy is a critical complication of treatment for cancer. The emotional stress of a cancer diagnosis, ongoing chemotherapy, abnormal cancer-related wasting syndrome may contribute to cardiac morbidity in these patients. The burden of Takotsubo Cardiomyopathy (TCM) in cancer patients is unknown. The incidence of TCM and related outcomes in cancer patients was investigated in this study. METHODS: The 2007-2013 National Inpatient Sample (NIS) was analyzed for patients with a prior and new diagnosis of TCM with and without malignancy...
May 14, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29752111/doxorubicin-dna-adduct-entrenched-and-motif-tethered-artificial-virus-encased-in-ph-responsive-polypeptide-complex-for-targeted-cancer-therapy
#2
K C Ajithkumar, K Pramod
Doxorubicin is a broad spectrum anticancer antibiotic that possesses toxic effects such as cardiomyopathy, that even lead to congestive heart failure. Thus, the development of a new bio-inspired system is required, that retain the advantageous effect of doxorubicin while retarding the side effects. Hence, a system was developed that we describe 'doxorubicin-DNA adduct entrenched artificial virus encased in polypeptide complex'. The drug-DNA adduct (DDA) was prepared by a formaldehyde mediated reaction. A simple chloroform extraction method for the separation of DDA was developed...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29736616/cardiac-mri-for-the-evaluation-of-oncologic-cardiotoxicity
#3
Adrián I Löffler, Michael Salerno
Cancer therapeutics-related cardiac dysfunction (CTRCD) is a well-established adverse effect resulting from a number of cancer therapeutics. Newer immunotherapy has been associated with cardiomyopathy and myocarditis making comprehensive imaging useful for early recognition. Cardiac MRI (CMR) offers a comprehensive evaluation to detect CTRCD. Established guidelines for monitoring left ventricular ejection fraction for potential cardiotoxicity have recently incorporated CMR. We will review the utility of CMR in contemporary evaluation for potential oncologic cardiotoxicity...
May 7, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29729319/autophagy-and-lysosomal-pathways-in-nervous-system-disorders
#4
REVIEW
Baris Bingol
Autophagy is an evolutionarily conserved pathway for delivering cytoplasmic cargo to lysosomes for degradation. In its classically studied form, autophagy is a stress response induced by starvation to recycle building blocks for essential cellular processes. In addition, autophagy maintains basal cellular homeostasis by degrading endogenous substrates such as cytoplasmic proteins, protein aggregates, damaged organelles, as well as exogenous substrates such as bacteria and viruses. Given their important role in homeostasis, autophagy and lysosomal machinery are genetically linked to multiple human disorders such as chronic inflammatory diseases, cardiomyopathies, cancer, and neurodegenerative diseases...
May 2, 2018: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/29717981/electron-cryo-microscopy-structure-of-the-canonical-trpc4-ion-channel
#5
Deivanayagabarathy Vinayagam, Thomas Mager, Amir Apelbaum, Arne Bothe, Felipe Merino, Oliver Hofnagel, Christos Gatsogiannis, Stefan Raunser
Canonical transient receptor channels (TRPC) are non-selective cation channels. They are involved in receptor-operated Ca2+ signaling and have been proposed to act as store-operated channels (SOC). Their malfunction is related to cardiomyopathies and their modulation by small molecules has been shown to be effective against renal cancer cells. The molecular mechanism underlying the complex activation and regulation is poorly understood. Here, we report the electron cryo-microscopy structure of zebrafish TRPC4 in its unliganded (apo), closed state at an overall resolution of 3...
May 2, 2018: ELife
https://www.readbyqxmd.com/read/29715123/takotsubo-cardiomyopathy-developed-after-two-stage-surgery-for-double-primary-lung-cancer
#6
Fumihiko Kinoshita, Gouji Toyokawa, Tetsuzo Tagawa, Taichi Matsubara, Yuka Kozuma, Naoki Haratake, Shinkichi Takamori, Takaki Akamine, Fumihiko Hirai, Yoshihiko Maehara
Takotsubo cardiomyopathy (TC) is a syndrome characterized by transient local systolic dysfunction of the left ventricle with no evidence of coronary artery disease or acute plaque rupture. We present the case of 71-year-old woman who developed TC after two-stage surgery for double primary lung cancer. On computed tomography, lung nodules were identified in the left upper and right middle lobes. Based on the diagnosis of double primary lung cancer, we performed two-stage surgery (left upper lobectomy followed by right middle lobectomy)...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29713021/risk-of-cardiomyopathy-and-cardiac-arrhythmias-in-patients-with-nonalcoholic-fatty-liver-disease
#7
REVIEW
Quentin M Anstee, Alessandro Mantovani, Herbert Tilg, Giovanni Targher
Nonalcoholic fatty liver disease (NAFLD) is a common, progressive liver disease that affects up to one-quarter of the adult population worldwide. The clinical and economic burden of NAFLD is mainly due to liver-related morbidity and mortality (nonalcoholic steatohepatitis, cirrhosis or hepatocellular carcinoma) and an increased risk of developing fatal and nonfatal cardiovascular disease, chronic kidney disease and certain types of extrahepatic cancers (for example, colorectal cancer and breast cancer). Additionally, there is now accumulating evidence that NAFLD adversely affects not only the coronary arteries (promoting accelerated coronary atherosclerosis) but also all other anatomical structures of the heart, conferring an increased risk of cardiomyopathy (mainly left ventricular diastolic dysfunction and hypertrophy, leading to the development of congestive heart failure), cardiac valvular calcification (mainly aortic-valve sclerosis), cardiac arrhythmias (mainly atrial fibrillation) and some cardiac conduction defects...
April 30, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29698683/anticancer-drug-induced-cardiac-rhythm-disorders-current-knowledge-and-basic-underlying-mechanisms
#8
REVIEW
Joachim Alexandre, Javid Moslehi, Kevin R Bersell, Christian Funck-Brentano, Dan M Roden, Joe-Elie Salem
Significant advances in cancer treatment have resulted in decreased cancer related mortality for many malignancies with some cancer types now considered chronic diseases. Despite these improvements, there is increasing recognition that many cancer patients or cancer survivors can develop cardiovascular diseases, either due to the cancer itself or as a result of anticancer therapy. Much attention has focused on heart failure; however, other cardiotoxicities, notably cardiac rhythm disorders, can occur without underlying cardiomyopathy...
April 24, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29660923/haemochromatosis-pathophysiology-and-the-red-blood-cell1
#9
Kieran J Richardson, Antony P McNamee, Michael J Simmonds
Haemochromatosis remains the most prevalent genetic disorder of Caucasian populations in Australia and the United States, occurring in ∼1 of 200 individuals and having a carrier frequency of 10-14%. Hereditary haemochromatosis is an autosomal recessive condition, that is phenotypically characterised by a gradual accumulation of iron, above and beyond that required for biological function. Once the binding capacity of iron carriers reaches saturation, the highly reactive free iron generates radicals that may lead to widespread cellular dysfunction...
April 7, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29660505/gcn2-deficiency-ameliorates-doxorubicin-induced-cardiotoxicity-by-decreasing-cardiomyocyte-apoptosis-and-myocardial-oxidative-stress
#10
Yue Wang, Tong Lei, Juntao Yuan, Yongguang Wu, Xiyue Shen, Junling Gao, Wei Feng, Zhongbing Lu
The clinical use of doxorubicin for cancer therapy is limited by its cardiotoxicity, which involves cardiomyocyte apoptosis and oxidative stress. Previously, we showed that general control nonderepressible 2 (GCN2), an eukaryotic initiation factor 2α (eIF2α) kinase, impairs the ventricular adaptation to chronic pressure overload by affecting cardiomyocyte apoptosis. However, the impact of GCN2 on Dox-induced cardiotoxicity has not been investigated. In the present study, we treated wild type (WT) and Gcn2-/- mice with four intraperitoneal injections (5 mg/kg/week) to induce cardiomyopathy...
April 7, 2018: Redox Biology
https://www.readbyqxmd.com/read/29644219/management-of-chemotherapy-induced-left-ventricular-dysfunction-and-heart-failure-in-patients-with-cancer-while-undergoing-cancer-treatment-the-md-anderson-practice
#11
Anecita P Fadol
Chemotherapy-induced cardiotoxicity resulting in heart failure (HF) is one of the most dreaded complications of cancer therapy that can significantly impact morbidity and mortality. With a high prevalence of cardiovascular disease in cancer patients, the risk of developing HF is significantly increased. A new discipline of Onco-Cardiology has evolved to address the cardiovascular needs of patients with cancer, however, there is limited evidence-based data to guide clinical decision-making in the management of the cardiovascular complications of cancer therapy...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29618792/subcutaneous-ehrlich-ascites-carcinoma-mice-model-for-studying-cancer-induced-cardiomyopathy
#12
Sneha Mishra, Ankit Kumar Tamta, Mohsen Sarikhani, Perumal Arumugam Desingu, Shruti M Kizkekra, Anwit Shriniwas Pandit, Shweta Kumar, Danish Khan, Sathees C Raghavan, Nagalingam R Sundaresan
Cardiomyopathy is one of the characteristic features of cancer. In this study, we establish a suitable model to study breast cancer-induced cardiomyopathy in mice. We used Ehrlich Ascites Carcinoma cells to induce subcutaneous tumor in 129/SvJ mice and studied its effect on heart function. In Ehrlich Ascites Carcinoma bearing mice, we found significant reduction in left ventricle wall thickness, ejection fraction, and fractional shortening increase in left ventricle internal diameter. We found higher muscle atrophy, degeneration, fibrosis, expression of cell-adhesion molecules and cell death in tumor-bearing mice hearts...
April 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29611048/use-of-speckle-tracking-in-the-evaluation-of-late-subclinical-myocardial-damage-in-survivors-of-childhood-acute-leukaemia
#13
Elena Guadalupe Corella Aznar, Ariadna Ayerza Casas, Lorenzo Jiménez Montañés, Maria Ángeles Carlota Calvo Escribano, José Ignacio Labarta Aizpún, Pilar Samper Villagrasa
Heart disease is the leading cause of non-cancer death in childhood cancer survivors. to determine the prevalence of subclinical cardiac dysfunction using speckle tracking and compare its results with those obtained by classical methods of assessing left ventricular function and its relationship with different factors to identify the population at higher risk. Echocardiographic assessment of left ventricular function included ejection fraction, tissue Doppler, longitudinal/circumferential strains and biochemical parameters (troponin-T and Pro-BNP) in a cohort of 57 survivors of childhood acute leukaemia with at least 10 years since diagnosis...
April 2, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29570223/an-investigation-of-the-monoamine-oxidase-inhibition-properties-of-pyrrolo-3-4-f-indole-5-7-dione-and-indole-5-6-dicarbonitrile-derivatives
#14
Zhanna V Chirkova, Mariya V Kabanova, Sergey I Filimonov, Igor G Abramov, Anél Petzer, Idalet Engelbrecht, Jacobus P Petzer, Kyrill Yu Suponitsky, Alexander V Veselovsky
Hit, Lead & Candidate Discovery In recent studies, we have shown that pyrrolo[3,4-f]indole-5,7-dione and indole-5,6-dicarbonitrile derivatives act as good potency in vitro inhibitors of the monoamine oxidase (MAO) enzymes. To expand on these series and to further derive structure-activity relationships (SARs) for MAO inhibition, in the present study we synthesized additional homologs and related analogs of these chemical classes. Analyzes of the MAO inhibition properties of the synthesized compounds show that among the pyrrolo[3,4-f]indole-5,7-dione derivatives good potency MAO inhibitors exist as exemplified by 10, which possesses IC50 values for the inhibition of MAO-A and MAO-B of 0...
March 23, 2018: Drug Development Research
https://www.readbyqxmd.com/read/29559248/role-of-mir-452-5p-in-the-tumorigenesis-of-prostate-cancer-a-study-based-on-the-cancer-genome-atl-tcga-gene-expression-omnibus-geo-and-bioinformatics-analysis
#15
Li Gao, Li-Jie Zhang, Sheng-Hua Li, Li-Li Wei, Bin Luo, Rong-Quan He, Shuang Xia
BACKGROUND: MiR-452-5p has been reported to be down-regulated in prostate cancer, affecting the development of this type of cancer. However, the molecular mechanism of miR-452-5p in prostate cancer remains unclear. Therefore, we investigated the network of target genes of miR-452-5p in prostate cancer using bioinformatics analyses. MATERIALS AND METHODS: We first analyzed the expression profiles and prognostic value of miR-452-5p in prostate cancer tissues from a public database...
March 6, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29549978/pitfalls-and-misinterpretations-of-cardiac-findings-on-pet-ct-imaging-a-careful-look-at-the-heart-in-oncology-patients
#16
REVIEW
Sonia L Betancourt Cuellar, Diana Palacio, Marcelo F Benveniste, Brett W Carter, Gregory Gladish
Positron emission tomography (PET) computed tomography (CT) with 2-[fluorine-18] fluoro-2-deoxy-d-glucose (FDG) has been established as an effective modality for evaluation of cancer. Interpretations of patterns of physiologic18 F-FDG uptake by the heart is particularly difficult given the wide normal variations of18 F-FDG metabolic activity observed. Atypical patterns of focal or diffuse physiologic cardiac18 F-FDG uptake and post-therapeutic effects after radiation therapy, systemic diseases, or cardiomyopathy may also be confused with malignant disease on18 F-FDG PET/CT...
February 6, 2018: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/29530484/cartilage-oligomeric-matrix-protein-compopathies-and-beyond
#17
REVIEW
Karen L Posey, Francoise Coustry, Jacqueline T Hecht
Cartilage oligomeric matrix protein (COMP) is a large pentameric glycoprotein that interacts with multiple extracellular matrix proteins in cartilage and other tissues. While, COMP is known to play a role in collagen secretion and fibrillogenesis, chondrocyte proliferation and mechanical strength of tendons, the complete range of COMP functions remains to be defined. COMPopathies describe pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED), two skeletal dysplasias caused by autosomal dominant COMP mutations...
March 9, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29508087/cardiovascular-complications-of-multiple-myeloma-treatment-evaluation-management-and-prevention
#18
REVIEW
Dae Hyun Lee, Michael G Fradley
PURPOSE OF REVIEW: Multiple myeloma treatment regimens consist of proteasome inhibitors (bortezomib, carfilzomib, and ixazomib), immunomodulatory drugs (thalidomide, lenalidomide, and pomalidomide), and steroids. In this paper, we will review the pathophysiology and associated cardiotoxicities of the different multiple myeloma therapeutic modalities and present methods to mitigate the development of cardiovascular complications. RECENT FINDINGS: Although proteasome inhibitors and immunomodulatory drugs have led to significant improvements in oncologic outcomes, there is increasing evidence of serious cardiovascular side effects which may be exacerbated in the setting of underlying cardiovascular risk factors or disease...
March 6, 2018: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29505798/in-silico-study-of-toxicokinetics-and-disease-association-of-chemicals-present-in-smokeless-tobacco-products
#19
Deeksha Bhartiya, Amit Kumar, Jasmine Kaur, Suchitra Kumari, Amitesh Kumar Sharma, Dhirendra N Sinha, Harpreet Singh, Ravi Mehrotra
Smokeless tobacco (SLT) products are consumed by millions of people in over 130 countries around the world. Consumption of SLT has been estimated to cause a number of diseases accounting to more than 0.65 million deaths per year. There is sufficient epidemiological evidence on the association of SLT products with nicotine addiction, cancers of oral cavity and digestive systems but there is a lack of understanding of the role of toxic chemicals in these diseases. We provide the first comprehensive in-silico analysis of chemical compounds present in different SLT products used worldwide...
June 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29498367/takotsubo-cardiomyopathy-in-a-young-male-with-lung-cancer-and-neoplastic-embolization-of-the-coronary-microcirculation
#20
Waldemar Elikowski, Małgorzata Małek-Elikowska, Stanisław Łazowski, Magdalena Zawodna, Natalia Fertała, Maciej Bryl
The associations between stress-induced takotsubo cardiomyopathy (TC) and cancer or its therapy have been studied with increasing interest in recent years. Different mechanisms of TC development in neoplastic disease are suggested, including a decreased threshold for stress stimuli or aggravated heart adrenoreceptors sensitivity. The action of cytokines and reactive oxygen species on the myocardium, on the epicardial arteries as well as on the coronary microcirculation is also taken into consideration. The authors describe a case of a 30-year-old male with lung cancer, after immunotherapy with checkpoint inhibitors followed by two lines of chemotherapy and after pericardial and pleural drainage...
February 23, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
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