Benjamin Lacas, Alexandra Carmel, Cécile Landais, Stuart J Wong, Lisa Licitra, Jeffrey S Tobias, Barbara Burtness, Maria Grazia Ghi, Ezra E W Cohen, Cai Grau, Gregory Wolf, Ricardo Hitt, Renzo Corvò, Volker Budach, Shaleen Kumar, Sarbani Ghosh Laskar, Jean-Jacques Mazeron, Lai-Ping Zhong, Werner Dobrowsky, Pirus Ghadjar, Carlo Fallai, Branko Zakotnik, Atul Sharma, René-Jean Bensadoun, Maria Grazia Ruo Redda, Séverine Racadot, George Fountzilas, David Brizel, Paolo Rovea, Athanassios Argiris, Zoltán Takácsi Nagy, Ju-Whei Lee, Catherine Fortpied, Jonathan Harris, Jean Bourhis, Anne Aupérin, Pierre Blanchard, Jean-Pierre Pignon
BACKGROUND AND PURPOSE: The Meta-Analysis of Chemotherapy in squamous cell Head and Neck Cancer (MACH-NC) demonstrated that concomitant chemotherapy (CT) improved overall survival (OS) in patients without distant metastasis. We report the updated results. MATERIALS AND METHODS: Published or unpublished randomized trials including patients with non-metastatic carcinoma randomized between 1965 and 2016 and comparing curative loco-regional treatment (LRT) to LRT + CT or adding another timing of CT to LRT + CT (main question), or comparing induction CT + radiotherapy to radiotherapy + concomitant (or alternating) CT (secondary question) were eligible...
March 2021: Radiotherapy and Oncology