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Choosing wisely

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https://www.readbyqxmd.com/read/28541184/the-step-wise-pathway-of-septin-hetero-octamer-assembly-in-budding-yeast
#1
Andrew D Weems, Michael A McMurray
Septin proteins bind guanine nucleotides and form rod-shaped hetero-oligomers. Cells choose from a variety of available septins to assemble distinct hetero-oligomers, but the underlying mechanism was unknown. Using a new in vivo assay, we find that a stepwise assembly pathway produces the two species of budding yeast septin hetero-octamers: Cdc11/Shs1-Cdc12-Cdc3-Cdc10-Cdc10-Cdc3-Cdc12-Cdc11/Shs1. Rapid GTP hydrolysis by monomeric Cdc10 drives assembly of the core Cdc10 homodimer. The extended Cdc3 N terminus autoinhibits Cdc3 association with Cdc10 homodimers until prior Cdc3-Cdc12 interaction...
May 25, 2017: ELife
https://www.readbyqxmd.com/read/28540247/trimodality-therapy-in-variant-urothelial-carcinoma-choose-wisely
#2
EDITORIAL
Panagiotis J Vlachostergios, Christopher Jakubowski, Scott T Tagawa
No abstract text is available yet for this article.
April 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28536760/-choosing-wisely-evidence-based
#3
EDITORIAL
G Hasenfuß, E Märker-Hermann, M Hallek, C C Sieber, U R Fölsch
No abstract text is available yet for this article.
May 23, 2017: Der Internist
https://www.readbyqxmd.com/read/28516250/-choosing-wisely-recommendations-in-angiology
#4
O J Müller, R Sternitzky
BACKGROUND: The Choosing wisely initiative addresses measures of high medical impact which are frequently not appropriately performed according to expert opinion. OBJECTIVE: To increase the quality of indications by providing supportive information on diagnostic and therapeutic measures in the field of angiology. MATERIALS AND METHODS: As part of the Choosing wisely initiative, the German Society of Angiology has constructed five positive recommendations on underused measures and five negative recommendations concerning those possibly overused...
May 17, 2017: Der Internist
https://www.readbyqxmd.com/read/28509818/commentary-on-variations-in-health-insurance-policies-regarding-biological-therapy-use-in-ibd-and-a-modified-delphi-process-for-the-development-of-choosing-wisely-for-ibd
#5
https://www.readbyqxmd.com/read/28509817/modified-delphi-process-for-the-development-of-choosing-wisely-for-inflammatory-bowel-disease
#6
Geoffrey C Nguyen, Karen Boland, Waqqas Afif, Brian Bressler, Jennifer L Jones, Adam V Weizman, Sharyle Fowler, Smita Halder, Vivian W Huang, Gilaad G Kaplan, Reena Khanna, Sanjay K Murthy, Joannie Ruel, Cynthia H Seow, Laura E Targownik, Tanya Chawla, Luis Guimaraes, Aida Fernandes, Sherif Saleh, Gil Y Melmed
BACKGROUND AND AIMS: The prevalence and incidence of inflammatory bowel disease (IBD) in North America is among the highest in the world and imparts substantial direct and indirect medical costs. The Choosing Wisely Campaign was launched in wide variety of medical specialties and disciplines to reduce unnecessary or harmful tests or treatment interventions. METHODS: The Choosing Wisely list for IBD was developed by the Canadian IBD Network for Research and Growth in Quality Improvement (CINERGI) in collaboration with Crohn's and Colitis Canada (CCC) and the Canadian Association of Gastroenterology (CAG)...
June 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28509769/commentary-on-variations-in-health-insurance-policies-regarding-biological-therapy-use-in-ibd-and-a-modified-delphi-process-for-the-development-of-choosing-wisely-for-ibd
#7
https://www.readbyqxmd.com/read/28509768/modified-delphi-process-for-the-development-of-choosing-wisely-for-inflammatory-bowel-disease
#8
Geoffrey C Nguyen, Karen Boland, Waqqas Afif, Brian Bressler, Jennifer L Jones, Adam V Weizman, Sharyle Fowler, Smita Halder, Vivian W Huang, Gilaad G Kaplan, Reena Khanna, Sanjay K Murthy, Joannie Ruel, Cynthia H Seow, Laura E Targownik, Tanya Chawla, Luis Guimaraes, Aida Fernandes, Sherif Saleh, Gil Y Melmed
BACKGROUND AND AIMS: The prevalence and incidence of inflammatory bowel disease (IBD) in North America is among the highest in the world and imparts substantial direct and indirect medical costs. The Choosing Wisely Campaign was launched in wide variety of medical specialties and disciplines to reduce unnecessary or harmful tests or treatment interventions. METHODS: The Choosing Wisely list for IBD was developed by the Canadian IBD Network for Research and Growth in Quality Improvement (CINERGI) in collaboration with Crohn's and Colitis Canada (CCC) and the Canadian Association of Gastroenterology (CAG)...
May 15, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28500196/choosing-wisely-canada
#9
Alexander Singer
No abstract text is available yet for this article.
May 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/28498197/overuse-of-health-care-services-in-the-management-of-cancer-a-systematic-review
#10
Shrujal S Baxi, Minal Kale, Salomeh Keyhani, Benjamin R Roman, Annie Yang, Antonio P Derosa, Deborah Korenstein
BACKGROUND: Overuse, the provision of health services for which harms outweigh the benefits, results in suboptimal patient care and may contribute to the rising costs of cancer care. We performed a systematic review of the evidence on overuse in oncology. METHODS: We searched Medline, EMBASE, the Cochrane Library, Web of Science, SCOPUS databases, and 2 grey literature sources, for articles published between December 1, 2011 and March 10, 2017. We included publications from December 2011 to evaluate the literature since the inception of the ABIM Foundation's Choosing Wisely initiative in 2012...
May 11, 2017: Medical Care
https://www.readbyqxmd.com/read/28497379/-choosing-wisely-recommendations-in-cardiology
#11
REVIEW
K Werdan, S Baldus, N Frey, U Nixdorff, K-H Kuck, H Katus
This article describes controversially discussed Choosing wisely recommendations presented by the German Cardiac Society: anticoagulation therapy in patients with atrial fibrillation and "only" moderate stroke risk, on the one hand, and goal-directed low-density lipoprotein (LDL) cholesterol-lowering, on the other. Presuming an adequate regime, patients with atrial fibrillation and only moderate risk of stroke (CHA2DS2-VASc Score of 1 in men and of 2 in women) also benefit from anticoagulation therapy, even in elderly patients...
May 11, 2017: Der Internist
https://www.readbyqxmd.com/read/28497377/-choosing-wisely-recommendations-in-hematology-and-oncology
#12
REVIEW
S W Krause, A Neubauer
Many new diagnostic and therapeutic options have been introduced in the field of hematology and medical oncology during recent years. Rational treatment recommendations are thus of even greater importance. Five presumably underused measures are recommended (positive recommendations), primarily pertaining to supportive therapy, but also concerning the selective use of molecular diagnostics. Recommendations to avoid unnecessary procedures (negative recommendations) involve a possible excessive use of anticancer therapy and imaging, and insufficiently selective use of growth factors, antiemetics, and targeted therapies...
May 11, 2017: Der Internist
https://www.readbyqxmd.com/read/28492993/-choosing-wisely-at-the-end-of-life-recommendations-of-the-german-society-for-palliative-medicine-dgp
#13
REVIEW
B Alt-Epping
In addition to an overuse of unnecessary or no longer indicated diagnostic or therapeutic procedures at the end of life in the sense of overtreatment, there is often also a lack of therapeutic awareness in terms of a healthcare deficit, for example concerning the recognition and treatment of symptoms and complex burden of the disease. Sticking closely to the methodology of the German S3 "Palliative Medicine" guideline, the Choosing wisely recommendations of the German Society for Palliative Medicine address various examples of over- and underuse of healthcare services and treatment at the end of life, and thus also mirror basic principles of palliative medical care...
May 10, 2017: Der Internist
https://www.readbyqxmd.com/read/28492992/-choosing-wisely-recommendations-in-gastroenterology
#14
REVIEW
H Koop, P Lynen Jansen, S Zeuzem
The Choosing wisely initiative of the German Society of Internal Medicine addresses procedures which are inadequately implemented (deficits in patient care) as well as those which are performed too often but without proven benefits for patients (misuse or overuse of health services). Based on their guidelines, The German Society of Gastroenterology, Digestive and Metabolic Diseases has identified such aspects and incorporated them into the respective recommendations.
May 10, 2017: Der Internist
https://www.readbyqxmd.com/read/28488056/-choosing-wisely-recommendations-in-intensive-care-medicine
#15
REVIEW
R Riessen, S Kluge, U Janssens, H Kierdorf, K F Bodmann, H-J Busch, S John, M Möckel
Intensive care medicine is an important and integral part of internal medicine. Modern intensive care medicine permits survival of many patients with severe and life-threatening internal diseases in acute situations. Decisive for therapeutic success is often not the application of complicated and expensive medical technologies, but rather the rapid diagnosis and identification of core issues, with immediate and competent initiation of standard treatment regimens. An adequately staffed, well-organized interprofessional team is of central importance...
May 9, 2017: Der Internist
https://www.readbyqxmd.com/read/28488055/-choosing-wisely-recommendations-in-nephrology
#16
REVIEW
J Galle, J Floege
The German Society of Internal Medicine ("Deutsche Gesellschaft für Innere Medizin", DGIM) founded the Choosing wisely initiative in order to address diagnostic and therapeutic procedures that are frequently inappropriately applied, whether this be in terms of over-, under-, or misuse of health services. The German Society of Nephrology ("Deutsche Gesellschaft für Nephrologie," DGfN) strongly supports the initiative and has contributed five positive and five negative recommendations. These ten recommendations are discussed in the current publication...
May 9, 2017: Der Internist
https://www.readbyqxmd.com/read/28488054/-choosing-wisely-recommendations-in-rheumatology-one-year-after-their-first-publication
#17
REVIEW
E Märker-Hermann, A J Voormann
Almost 1 year after publication of the Choosing wisely recommendations ("Klug-entscheiden-Empfehlungen," KEE) for rheumatology, it is evident that they have found their way into specialist and lay publications, the media used by self-help groups, online media, and continuing education congresses. As such, a broad target audience has been reached. In the meantime, newly established or updated guidelines have been published which incorporate the KEE for rheumatology. The KEE provide a gateway into clinical Standard Operating Procedures or recommendations...
May 9, 2017: Der Internist
https://www.readbyqxmd.com/read/28480283/using-nuclear-medicine-imaging-wisely-in-diagnosing-infectious-diseases
#18
REVIEW
Andrea Censullo, Tara Vijayan
In recent years, there has been an increasing emphasis on efficient and accurate diagnostic testing, exemplified by the American Board of Internal Medicine's "Choosing Wisely" campaign. Nuclear imaging studies can provide early and accurate diagnoses of many infectious disease syndromes, particularly in complex cases where the differential remains broad. This review paper offers clinicians a rational, evidence-based guide to approaching nuclear medicine tests, using an example case of methicillin-sensitive Staphylococcus aureus (MSSA) bacteremia in a patient with multiple potential sources...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28477038/-response-to-and-further-development-of-the-choosing-wisely-initiative
#19
REVIEW
U R Fölsch, M Hallek, T Raupach, G Hasenfuß
The Choosing wisely initiative of the German Society of Internal Medicine ("Deutschen Gesellschaft für Innere Medizin," DGIM) and its 12 core focus area specialist societies were brought into being in 2014. The German initiative differs from the American campaign in that it not only considers overuse of diagnostic and therapeutic healthcare services, but also addresses procedures which are frequently not performed although they would bring benefits for patients. Furthermore, the recommendations were approved by an interdisciplinary consensus commission under consideration of all key internal medicine aspects...
May 5, 2017: Der Internist
https://www.readbyqxmd.com/read/28473305/quality-of-social-media-and-web-based-information-regarding-inappropriate-nuclear-cardiac-stress-testing-and-the-choosing-wisely-campaign-a-cross-sectional-study
#20
David E Winchester, Diana Baxter, Merry J Markham, Rebecca J Beyth
BACKGROUND: The World Wide Web and social media provide the public with access to medical information unlike any other time in human history. However, the quality of content related to cardiac stress testing is not well understood. OBJECTIVE: The aim of our study was to evaluate the quality of content on the Internet relating to the use of cardiac nuclear stress testing and the Choosing Wisely campaign. METHODS: We searched the World Wide Web, Google Video (including YouTube), and Twitter for information relating to these two topics...
May 4, 2017: Interactive Journal of Medical Research
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