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Benoîte Bourdin, Emilie Segura, Marie-Philippe Tétreault, Sylvie Lesage, Lucie Parent
Inherited or de novo mutations in cation-selective channels may lead to sudden cardiac death. Alteration in the plasma membrane trafficking of these multi-spanning transmembrane proteins, with or without change in channel gating, is often postulated to contribute significantly in this process. It has thus become critical to develop a method to quantify the change of the relative cell surface expression of cardiac ion channels on a large scale. Herein, a detailed protocol is provided to determine the relative total and cell surface expression of cardiac L-type calcium channels CaV1...
September 28, 2016: Journal of Visualized Experiments: JoVE
Hélio A G Teive, Délcio C Bertucci, Renato P Munhoz
Objective: Patients with Parkinson's disease (PD) may present with unusual motor and non-motor symptoms and signs in the early stage of the disease. Methods: Cases were collected over a five-year period at two tertiary movement disorders clinics. All had a diagnosis of PD with unusual presentations defined retrospectively as the presence of complaints not objectively related to any of the classic cardinal signs of parkinsonism or the typical early non-motor features of PD...
October 2016: Arquivos de Neuro-psiquiatria
A Carson, L Ludwig, K Welch
In this chapter we review key psychologic theories that have been mooted as possible explanations for the etiology of functional neurologic symptoms, conversion disorder, and hysteria. We cover Freudian psychoanalysis and later object relations and attachment theories, social theories, illness behavior, classic and operant conditioning, social learning theory, self-regulation theory, cognitive-behavioral theories, and mindfulness. Dissociation and modern cognitive neuroscience theories are covered in other chapters in this series and, although of central importance, are omitted from this chapter...
2017: Handbook of Clinical Neurology
Harun Karimpur, Kai Hamburger
Spatial representations are a result of multisensory information integration. More recent findings suggest that the multisensory information processing of a scene can be facilitated when paired with a semantically congruent auditory signal. This congruency effect was taken as evidence that audio-visual integration occurs for complex scenes. As navigation in our environment consists of a seamless integration of complex sceneries, a fundamental question arises: how is human landmark-based wayfinding affected by multimodality? In order to address this question, two experiments were conducted in a virtual environment...
2016: Frontiers in Psychology
Andrea Castiello D'Antonio
No abstract text is available yet for this article.
October 2016: Psychoanalytic Quarterly
Alyssa Chappell, Katelyn Dervay
Purpose: To describe an innovative strategy for incorporating leadership training and development across multiple postgraduate year 2 (PGY2) pharmacy residency programs at a single institution. Background: Tampa General Hospital has 7 pharmacy residency positions: 4 postgraduate year 1 (PGY1) residents and a single resident for each of the 3 PGY2 programs (critical care, emergency medicine, and solid organ transplant). Administrative topics are incorporated across the PGY1 and PGY2 residency programs, with each PGY2 program having additional administrative topics specific to their specialty area...
September 2016: Hospital Pharmacy
Lei Yuan, David Uttal, Steven Franconeri
Perceiving not just values, but relations between values, is critical to human cognition. We tested the predictions of a proposed mechanism for processing categorical spatial relations between two objects-the shift account of relation processing-which states that relations such as 'above' or 'below' are extracted by shifting visual attention upward or downward in space. If so, then shifts of attention should improve the representation of spatial relations, compared to a control condition of identity memory...
2016: PloS One
Louise Martin, Bonita Lloyd, Paul Cammell, Frank Yeomans
OBJECTIVE: This article discusses Transference-Focused Psychotherapy, a contemporary evidence-based and manualised form of psychoanalytic psychotherapy for borderline personality disorder. Transference focused psychotherapy has evolved from decades of research in the object-relations approach developed by Professor Otto Kernberg and his collaborators. It is being adopted increasingly throughout North and South America and Europe, and this article explores the role its adoption might play in psychiatric training as well as public and private service provision contexts in Australia...
September 27, 2016: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
David Kealy, John S Ogrodniczuk, William E Piper, Carlos A Sierra-Hernandez
Group psychotherapy provides unique opportunities for clinical errors in the selection of patients and composition of therapy groups. This article introduces some of the difficulties and complexities that can be associated with group composition and patient selection errors. Clinical vignettes from psychodynamic/interpersonal psychotherapy groups are used to illustrate three variations of group composition and selection errors. The first vignette depicts an error in selecting a disruptive patient into a fledgling group...
September 2016: Psychotherapy
Sharon Ziv-Beiman, Golan Shahar
Ascending to prominence in virtually all forms of psychotherapy, therapist self-disclosure (TSD) has recently been identified as a primarily integrative intervention (Ziv-Beiman, 2013). In the present article, we discuss various instances in which using TSD in integrative psychotherapy might constitute a clinical error. First, we briefly review extant theory and empirical research on TSD, followed by our preferred version of integrative psychotherapy (i.e., a version of Wachtel's Cyclical Psychodynamics [Wachtel, 1977, 1997, 2014]), which we title cognitive existential psychodynamics...
September 2016: Psychotherapy
Silvie Kloeters, Christian J Hartmann, Viktoria D Pundmann, Alfons Schnitzler, Martin Südmeyer, Joachim Lange
Interacting with other individuals in a social world requires fast and accurate perception of other individuals' identity, actions, or intentions. Humans are very efficient in these social tasks, as they can extract social information even if the actor is represented only by a handful of point-lights on an otherwise invisible body. Theories have argued that efficient visual perception of actions is based on intact motor system functioning. The motor system provides visuo-motor action representations shaped by the observer's own movements or motor repertoire...
September 5, 2016: Behavioural Brain Research
Anthony S J Mullin, Mark J Hilsenroth, Jerold Gold, Barry A Farber
This study explores the effectiveness of psychodynamic psychotherapy in improving facets of object relations (OR) functioning over the course of treatment. The sample consisted of 75 outpatients engaged in short-term dynamic psychotherapy at a university-based psychological services clinic. Facets of OR functioning were assessed at pre- and posttreatment by independent raters using the Social Cognition and Object Relations Scale-Global rating method (SCORS-G; Stein, Hilsenroth, Slavin-Mulford, & Pinsker, 2011 ; Westen, 1995 ) from in-session patient relational narratives...
September 8, 2016: Journal of Personality Assessment
Astrid Bock, Eva Huber, Cord Benecke
OBJECTIVES: For a clinically relevant understanding of facial displays of patients with mental disorders it is crucial to go beyond merely counting frequencies of facial expressions, but include the contextual information of the expression. We assume that patients with different levels of structural integration differ in the contextual embedding of their negative facial expressions of emotions. METHODS: Facial affective behaviour of 80 female participants during an OPD interview was analysed using FACS (Facial Action Coding System) and the RFE coding system (Referencesof- Facial-Expression coding system; Bock et al...
September 2016: Zeitschrift Für Psychosomatische Medizin und Psychotherapie
Tamerlan Saidov, Carola Heneweer, Maarten Kuenen, Julian von Broich-Oppert, Hessel Wijkstra, Jean de la Rosette, Massimo Mischi
Neoangiogenesis, which results in the formation of an irregular network of microvessels, plays a fundamental role in the growth of several types of cancer. Characterization of microvascular architecture has therefore gained increasing attention for cancer diagnosis, treatment monitoring and evaluation of new drugs. However, this characterization requires immunohistologic analysis of the resected tumors. Currently, dynamic contrast-enhanced ultrasound imaging (DCE-US) provides new options for minimally invasive investigation of the microvasculature by analysis of ultrasound contrast agent (UCA) transport kinetics...
September 1, 2016: Ultrasound in Medicine & Biology
Lily M Solomon-Harris, Sara A Rafique, Jennifer K E Steeves
The human cortical system for face perception comprises a network of connected regions including the middle fusiform gyrus ("fusiform face area" or FFA), the inferior occipital gyrus ("occipital face area" or OFA), and the posterior superior temporal sulcus (pSTS). Here, we sought to investigate how transcranial magnetic stimulation (TMS) to the OFA affects activity within the face processing network. We used offline repetitive TMS to temporarily introduce neural noise in the right OFA in healthy subjects. We then immediately performed functional magnetic resonance imaging (fMRI) to measure changes in blood oxygenation level dependent (BOLD) signal across the face network using an fMR-adaptation (fMR-A) paradigm...
November 1, 2016: Brain Research
Sabrine S Jensen, Henrik Jensen, David M Goodall, Jesper Østergaard
UV imaging is capable of providing spatially and temporally resolved absorbance measurements, which is highly beneficial in drug diffusion, dissolution and release testing studies. For optimal planning and design of experiments, knowledge about the capabilities and limitations of the imaging system is required. The aim of this study was to characterize the performance of two commercially available UV imaging systems, the D100 and SDI. Lidocaine crystals, lidocaine containing solutions, and gels were applied in the practical assessment of the UV imaging systems...
November 30, 2016: Journal of Pharmaceutical and Biomedical Analysis
Agnieszka Kubiak, Gregory Króliczak
Functional magnetic resonance imaging (fMRI) adaptation (a.k.a. repetition suppression) paradigm was used to test if semantic information contained in object-related (transitive) pantomimes and communicative (intransitive) gestures is represented differently in the occipito-temporal cortex. Participants watched 2.75 s back-to-back videos where the meaning of gesture was either repeated or changed. The just observed (typically second) gesture was then imitated. To maintain participants' attention, some trials contained a single video...
2016: Scientific Reports
Christiane Moro
Why have material world of daily life and material objects in their conventional features or to say it in other words, why have the mundane world and mundane objects, in which the human beings live and children come to, encounter, experience and develop through, received so little attention from psychologists thus remaining a blind spot in mainstream developmental psychology? Certainly the object has not been totally forgotten (e.g. Piaget's constructivist paradigm) but it has been considered as theoretically determined by the categories of understanding (cf...
December 2016: Integrative Psychological & Behavioral Science
Marie Béguin
The purpose of this contribution is to investigate the advent of language in the light of the appropriation of the cultural uses of the material objects related to material culture and the constitution of their public and shared meanings linked to their uses. First, we suggest that the Object Pragmatics paradigm offers a framework which allows us to take into account the uses of objects in daily life as a site of social conventions, communication and public and shared meanings. Second, we would like to underline the key role of the adult's mediations in the child's ability to evolve towards linguistic development...
December 2016: Integrative Psychological & Behavioral Science
Mantosh J Dewan
The focus on recent advances in the neurobiology of schizophrenia has pushed aside the psychological understanding of the person with schizophrenia for several decades. However, a useful functional psychology of schizophrenia (in distinction to a psychological approach to symptoms) remains clinically important for several reasons: it is a core part of the bio-psycho-social formulation; it helps us understand and connect with persons with schizophrenia; and it provides a framework by which to organize our treatment efforts (both psychotherapeutic and particularly biological), which can improve adherence and outcomes...
August 2016: Journal of Nervous and Mental Disease
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