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Guo jianming

Yang Qu, Li Liu, Jiajun Wang, Wei Xi, Yu Xia, Qi Bai, Ying Xiong, Qilai Long, Jiejie Xu, Jianming Guo
BACKGROUND: Disruptor of telomeric silencing 1-like (Dot1l), a histone methyltransferase that targets the histone H3 lysine 79 (H3K79), has been reported that its high expression is associated with various cancers, while the association between Dot1l expression and clear-cell renal cell carcinoma (ccRCC) is still unknown. PATIENTS AND METHODS: We retrospectively enrolled 282 patients with ccRCC undergoing nephrectomy from a single institution between 2005 and 2007, with a median follow-up of 99 months...
October 5, 2016: Oncotarget
Xiaoqing Yu, Xianran Li, Tingting Guo, Chengsong Zhu, Yuye Wu, Sharon E Mitchell, Kraig L Roozeboom, Donghai Wang, Ming Li Wang, Gary A Pederson, Tesfaye T Tesso, Patrick S Schnable, Rex Bernardo, Jianming Yu
The 7.4 million plant accessions in gene banks are largely underutilized due to various resource constraints, but current genomic and analytic technologies are enabling us to mine this natural heritage. Here we report a proof-of-concept study to integrate genomic prediction into a broad germplasm evaluation process. First, a set of 962 biomass sorghum accessions were chosen as a reference set by germplasm curators. With high throughput genotyping-by-sequencing (GBS), we genetically characterized this reference set with 340,496 single nucleotide polymorphisms (SNPs)...
October 3, 2016: Nature Plants
Jianming Guo, Yongquan Gu, Lianrui Guo, Zhu Tong, Xixiang Gao
Massive pulmonary embolism (MPE) is associated with a high rate of mortality, and chronic thromboembolic pulmonary hypertension leads to ongoing morbidity among many survivors. Here we report a case of a MPE successfully treated by Angiojet rheolytic thrombectomy combined with catheter fragmentation. This is the first report of the use of these two methods together for MPE treatment.
September 20, 2016: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
Wenhui Zhu, Hua Xu, Jing Ma, Jianming Guo, Wei Xue, Baojun Gu, Lu Sheng, Xudong Yao, Fukang Sun, Jian Gong, Weiliang Qiu, Qiang Ding, Haowen Jiang
PURPOSE: The study aimed to evaluate the effects of metformin on insulin, C-peptide and body weight in Chinese men undergoing androgen deprivation therapy (ADT). METHODS: Between March 2013 and June 2014, 62 newly diagnosed patients of prostate cancer (PCa) due to receive ADT were recruited from 7 hospitals in Shanghai. Patients were randomized to respectively receive ADT (n = 31) and ADT + metformin (n = 31) for 6 months. Fasting and postprandial serum levels of insulin and C-peptide, blood glucose, prostate specific antigen, body mass index (BMI) and waist circumference (WC) were measured at the beginning and end of 6-month treatment...
September 30, 2016: Urologia Internationalis
Wenbin Li, Jing Zhang, Lei Guo, Shannon Chuai, Ling Shan, Jianming Ying
INTRODUCTION: The purpose of this study was to explore the complicated rearrangement mechanisms underlying cases with atypical and negative anaplastic lymphoma receptor tyrosine kinase gene (ALK) fluorescence hybridization (FISH) and positive immunohistochemistry (IHC) results and to stress the importance of combinational assay of these two methods in current pathological diagnosis. METHODS: A total of 3128 NSCLCs were screened for ALK fusions through both FISH analysis and IHC assays with Ventana-D5F3 antibody...
September 8, 2016: Journal of Thoracic Oncology
Yu Xia, Li Liu, Qi Bai, Jiajun Wang, Wei Xi, Yang Qu, Ying Xiong, Qilai Long, Jiejie Xu, Jianming Guo
Dectin-1, a classical pattern-recognition receptor, was now identified as an important regulator in immune homeostasis and cancer immunity through its extensive ligands binding functions and subsequent cytokines production. The aim of this study was to assess the clinical significance of dectin-1 expression in 290 patients with clear cell renal cell carcinoma (ccRCC) through immunohistochemistry on tissue microarrays. We found that dectin-1 was predominantly expressed on ccRCC cells, in accordance with several other online databases...
2016: Scientific Reports
Juan Li, Xiaojie Liang, Yaguang Zhou, Shumiao Zhang, Fan Yang, Haitao Guo, Rong Fan, Na Feng, Min Jia, Yueming Wang, Mingchao Liu, Jianming Pei
Previously study showed κ-opioid receptor stimulation with exogenous κ-opioid receptor agonist elicited a protective effect against hypoxic pulmonary hypertension (HPH). However, the effect of endogenous κ-opioid receptor agonist dynorphin A on HPH remains unclear. This study was to determine the role of dynorphin in HPH. Hypoxia for 2 weeks induced HPH. Compared with the HPH group, the HPH + nor-BNI (a selective κ-opioid receptor antagonist) group showed a significant increase in mean pulmonary arterial pressure (mPAP)...
August 25, 2016: European Journal of Pharmacology
Ying Xiong, Li Liu, Yu Xia, Jiajun Wang, Wei Xi, Qi Bai, Yang Qu, Qilai Long, Jiejie Xu, Jianming Guo
We enrolled a total of 277 patients who received nephrectomy due to clear cell renal cell carcinoma (ccRCC) in Zhongshan Hospital from Jan 2005 to Jun 2007. Immunohistochemistry was performed to evaluate the impact of CLEC-2 positive cell infiltration on the overall survival (OS) and recurrence-free survival (RFS) of patients with ccRCC. Kaplan-Meier analysis showed that high CLEC-2 positive cell infiltration in tumor tissue indicated poorer OS and RFS (OS, p < 0.001; RFS, p = 0.002). High CLEC-2 positive cell infiltration is also an independent risk factor for OS and RFS in multivariate analyses (OS, p = 0...
August 25, 2016: Oncotarget
Qi Bai, Li Liu, Wei Xi, Jiajun Wang, Yu Xia, Yang Qu, Ying Xiong, Qilai Long, Jiejie Xu, Jianming Guo
BACKGROUND: Sialyltransferase ST6GalNAc-1 is highly expressed in tumor cells and associated with tumor aggressiveness and poor prognosis. In the present study, we aimed to investigate the clinical and prognostic significance of sialyltransferase ST6GalNAc-1 in patients with non-metastatic ccRCC. RESULTS: High expression of ST6GalNAc-1 in tumor tissue was an independent prognostic factor for overall survival (p<0.001) and recurrence free survival (p<0.001) in multivariate analysis...
August 12, 2016: Oncotarget
Jianming Wang, Yanzhen Zhang, Zhiling Guo, Qingwen Tao, Yongjun Wang, Wei Zhou, Xiao Ma, Zhihong Li
The purpose of this study was to propose the effectiveness of convolution approach to predict pharmacokinetics of tramadol hydrochloride floating tablets, prepared by using various ratios of carbopol, HPMC K100M, and Hibiscus rosa Sinensis as excipient. The in vitro dissolution test was conducted using paddle method in 900 mL of HCl buffer with pH 1.2 to simulate the gastric condition. The stirring speed of paddles was set at 70 rpm. Temperature of dissolution medium was adjusted at 37 ± 5 °C. At predetermined time points, 5 mL of dissolution samples were taken with a replacement of same volume using fresh medium...
May 2016: Acta Poloniae Pharmaceutica
Hang Wang, Qilai Long, Yiwei Wang, Li Liu, Lin Zhou, Jianming Guo
The aim of the present study was to investigate the treatment options for patients with tuberous sclerosis complex (TSC)-associated renal angiomyolipomas (AMLs). A total of 17 patients who were consecutively diagnosed with TSC-associated renal AMLs at the Department of Urology of Zhongshan Hospital between 1998 and 2012 were included in the study. The patient cohort included 7 males and 10 females with a mean age of 37.6 years (range, 18-62 years). A total of 12 patients were diagnosed with renal AML with TSC during physical examination (PE), while 5 patients were admitted to the Emergency Department of Zhongshan Hospital due to spontaneous rupture of renal AMLs...
August 2016: Oncology Letters
Hong Shen, Xinhua He, Yiqing Liu, Yi Chen, Jianming Tang, Tao Guo
Limited information is available if plant growth promoting bacteria (PGPB) can promote the growth of fruit crops through improvements in soil fertility. This study aimed to evaluate the capacity of PGPB, identified by phenotypic and 16S rRNA sequencing from a vegetable purple soil in Chongqing, China, to increase soil nitrogen (N), phosphorus (P), and potassium (K) availability and growth of kiwifruit (Actinidia chinensis). In doing so, three out of 17 bacterial isolates with a high capacity of N2-fixation (Bacillus amyloliquefaciens, XD-N-3), P-solubilization (B...
2016: Frontiers in Microbiology
Yun Ling, Xin Yang, Wenbin Li, Zhuo Li, Lin Yang, Tian Qiu, Lei Guo, Lin Dong, Lin Li, Jianming Ying, Dongmei Lin
BACKGROUND: Epidermal growth factor receptor (EGFR) is a novel target for therapy in a subset of non-small cell lung cancer (NSCLC). Tumors with EGFR mutations showed good response to EGFR tyrosine kinase inhibitors (TKIs). We aimed to identify the discriminating capacity of immunohistochemistry (IHC) to detect EGFR L858R and del E746-A750 mutations in NSCLC patients and predict EGFR TKIs response. MATERIALS AND METHODS: We collected specimens from 200 patients with NSCLC whose EGFR mutation status had been validated by direct DNA sequencing...
July 13, 2016: Oncotarget
Lei Guo, Wenbin Li, Xinxin Zhu, Yun Ling, Tian Qiu, Lin Dong, Yi Fang, Hongying Yang, Jianming Ying
PURPOSE: To estimate the therapeutic potential of PD-L1 inhibition in breast cancer, we evaluated the prevalence and significance of PD-L1 protein expression with a validated antibody and CD274 gene alternation in a large cohort of triple negative breast cancer (TNBC) and correlated with clinicopathological data and patients overall survival. METHODS: Immunohistochemistry and in situ mRNA hybridization was used to detect PD-L1 protein and mRNA expression in tumor tissues from 183 TNBC patients respectively...
2016: SpringerPlus
Yu Xia, Li Liu, Ying Xiong, Qi Bai, Jiajun Wang, Wei Xi, Yang Qu, Jiejie Xu, Jianming Guo
Podoplanin, a transmembrane sialomucin-like glycoprotein, was recently shown to be involved in tumor progression and metastasis, and its potential role in facilitating platelet-based tumor embolization and promigratory phenotype of cancer cells was also demonstrated. In this study, we assessed the clinical significance of tumoral podoplanin expression in 295 patients with clear cell renal cell carcinoma (ccRCC) through immunohistochemistry on tissue microarrays and analyzing the staining intensity. Univariate analysis suggested an adverse prognostic effect of high tumoral podoplanin expression on patients' overall survival (OS) and recurrence-free survival (RFS) (P < 0...
September 2016: Cancer Science
Wei Xi, Li Liu, Jiajun Wang, Yu Xia, Qi Bai, Qilai Long, Yiwei Wang, Jiejie Xu, Jianming Guo
Anaphylatoxin C5a, a potent pro-inflammatory peptide produced in the process of complement activation, was proved to have a vital role in tumor initiation and progession by previous investigations. However whether it could act as a prognostic marker remains unknown. Here we retrospectively enrolled 272 ccRCC patients undergoing nephrectomy in Zhongshan Hospital, Shanghai between 2005 and 2007. C5a level was assessed by immunohistochemistry and its association with clinicopathologic features and prognosis were evaluated...
2016: Scientific Reports
Shifang Ren, Zejian Zhang, Congjian Xu, Lin Guo, Renquan Lu, Yihong Sun, Jianming Guo, Ruihuan Qin, Wenjun Qin, Jianxin Gu
No abstract text is available yet for this article.
August 2016: Cell Research
Jiayong He, Ying Liu, Yun Kang, Ping Yang, Yaqin Wang, Jixian Guo, Jianming Huang
INTRODUCTION: Plants in the genus Stephania can produce diverse bioactive alkaloids. Stephania hainanensis is a medicinal plant that contains effective alkaloids. However, only 10 alkaloids have been reported in this species. OBJECTIVE: To characterise the alkaloids in Stephania hainanensis using liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (LC-QTOF-MS/MS). METHODS: An LC-QTOF-MS/MS method was developed for structural characterisation of the alkaloids in Stephania hainanensis...
May 2016: Phytochemical Analysis: PCA
Jianming Guo, Yongquan Gu, Lianrui Guo, Hengxi Yu, Lixing Qi, Zhu Tong, Jian Zhang, Zhonghao Wang
BACKGROUND: Patients undergoing carotid artery stenosis who are prescribed aspirin, clopidogrel, or sarpogrelate as treatment options to inhibit platelet aggregation continues to increase. The purpose of this study was to compare the efficacy and safety of clopidogrel combined with aspirin (CA) versus sarpogrelate combined with aspirin (SA) treatment in carotid endarterectomy (CEA) patients. METHODS: This retrospective study included 197 CEA patients (mean age 61...
August 2016: Annals of Vascular Surgery
Meilin Wang, Zhiqiang Li, Haiyan Chu, Qiang Lv, Dingwei Ye, Qiang Ding, Chuanliang Xu, Jianming Guo, Mulong Du, Jianhua Chen, Zhijian Song, Changjun Yin, Chao Qin, Chengyuan Gu, Yao Zhu, Guowei Xia, Fang Liu, Zhengsheng Zhang, Lin Yuan, Guangbo Fu, Zhibin Hu, Na Tong, Jiawei Shen, Ke Liu, Jielin Sun, Yinghao Sun, Jue Li, Xingwang Li, Hongbing Shen, Jianfeng Xu, Yongyong Shi, Zhengdong Zhang
Genome-wide association studies (GWAS) of bladder cancer have identified a number of susceptibility loci in European populations but have yet to uncover the genetic determinants underlying bladder cancer incidence among other ethnicities. Therefore, we performed the first GWAS in a Chinese cohort comprising 3,406 cases of bladder cancer and 4,645 controls. We identified a new susceptibility locus for bladder cancer at 5q12.3, located in the intron of CWC27 (rs2042329), that was significantly associated with disease risk (OR = 1...
June 1, 2016: Cancer Research
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