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https://www.readbyqxmd.com/read/28094950/capillary-force-induced-cold-welding-in-silver-nanowire-based-flexible-transparent-electrodes
#1
Yuan Liu, Jianming Zhang, Heng Gao, Yan Wang, Qingxian Liu, Siya Huang, Chuanfei Guo, Zhifeng Ren
Silver nanowire (AgNW) films have been studied as the most promising flexible transparent electrodes for flexible photoelectronics. The wire-wire junction resistance in the AgNW film is a critical parameter to the electrical performance, and several techniques of nanowelding or soldering have been reported to reduce the wire-wire junction resistance. However, these methods require either specific facilities, or additional materials as the "solder", and often have adverse effects to the AgNW film or substrate...
January 17, 2017: Nano Letters
https://www.readbyqxmd.com/read/28052014/met-overexpression-gene-amplification-and-relevant-clinicopathological-features-in-gastric-adenocarcinoma
#2
Jing Zhang, Lei Guo, Xiuyun Liu, Wenbin Li, Jianming Ying
This study was conducted to investigate the expression of MET in Chinese gastric adenocarcinoma cohort, the correlation between MET overexpression and clinical pathological features, HER2 expression and MET gene amplification. A total of 816 gastric adenocarcinoma patients were included and MET and HER2 immunohistochemical (IHC) staining were performed. IHC and dual-color silver in situ hybridization analysis were performed in the tissue microarrays, constructed from the 240 patients who were randomly selected...
December 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/28026934/modifying-mechanical-optical-properties-and-thermal-processability-of-iridescent-cellulose-nanocrystal-films-using-ionic-liquid
#3
Ping Liu, Xin Guo, Fuchun Nan, Yongxin Duan, Jianming Zhang
Iridescent films formed from the self-assembly of cellulose nanocrystals (CNCs) are brittle and difficult to handle or integrate within an industrial process. Here we present a simple approach to prepare iridescent CNC films with tunable pliability and coloration through the addition of ionic liquids (ILs) of 1-allyl-3-methylimidazolium chloride (AmimCl) as plasticizer. By using the un-dried CNC film as filter membrane and ILs solution as leaching liquor, it was found that the filtration process made ILs uniformly interpenetrate into CNC film due to the strong ionic interaction between CNC and AmimCl...
December 27, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28013179/simultaneous-quantification-and-semi-quantification-of-ginkgolic-acids-and-their-metabolites-in-rat-plasma-by-uhplc-ltq-orbitrap-ms-and-its-application-to-pharmacokinetics-study
#4
Yiyun Qian, Zhenhua Zhu, Jin-Ao Duan, Sheng Guo, Erxin Shang, Jinhua Tao, Shulan Su, Jianming Guo
A highly sensitive method using ultra-high-pressure liquid chromatography coupled with linear ion trap-Orbitrap tandem mass spectrometry (UHPLC-LTQ-Orbitrap-MS) has been developed and validated for the simultaneous identification and quantification of ginkgolic acids and semi-quantification of their metabolites in rat plasma. For the five selected ginkgolic acids, the method was found to be with good linearities (r>0.9991), good intra- and inter-day precisions (RSD<15%), and good accuracies (RE, from -10...
January 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27973865/ti2co2-nanotubes-with-negative-strain-energies-and-tunable-band-gaps-predicted-from-first-principles-calculations
#5
Xun Guo, Ping Zhang, Jianming Xue
MXenes, a series of two-dimensional (2D) layered early transition metal carbide, nitride, and carbonitride, have been prepared by exfoliating MAX phases recently. In addition to 2D planar MXene, one-dimensional tubular forms-MXene nanotubes-are also expected to form. Herein, we design atomic models for Ti2C as well as Ti2CO2 nanotubes in the 1-4 nm diameter range and investigate their basic properties through density functional theory (DFT). It is shown that though the strain energy of Ti2C nanotubes are always positive, Ti2CO2 nanotubes have negative strain energies when diameter beyond 2...
December 15, 2016: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/27958690/granulocyte-colony-stimulating-factor-improves-the-efficacy-of-autologous-bone-marrow-derived-mononuclear-cell-transplantation-treatment-for-lower-limb-ischemia
#6
Yongquan Gu, Lianrui Guo, Jianming Guo, Alan Dardik, Shuwen Zhang, Zhu Tong, Jian Zhang, Zhonghao Wang
BACKGROUND: The safety and efficacy of autologous bone marrow-derived mononuclear cell (BM-MNC) transplantation in the treatment of lower limb ischemia is becoming established, although common treatment protocols are not yet agreed upon. We hypothesized that bone marrow mobilization with Granulocyte Colony-Stimulating Factor (G-CSF) improves the safety and effectiveness of cellular therapy. METHODS: 44 patients were randomly assigned to receive two injections of G-CSF (300 μg) prior to BM-MNC transplantation...
December 13, 2016: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/27926489/suppression-of-immune-regulatory-cells-with-combined-therapy-of-celecoxib-and-sunitinib-in-renal-cell-carcinoma
#7
Qi Zhao, Jianming Guo, Guomin Wang, Yiwei Chu, Xiaoyi Hu
OBJECTIVE: To observe the the potential benefit of sunitinib in combination with cyclooxygenase-2(COX-2) inhibitor in renal cell carcinoma therapy. METHODS: 769-p cell lines were treated with sunitinib, celecoxib, or in combination at different concentrations respectively. We investigated the expression of granulocyte-macrophage colony stimulating factor (GM-CSF) in 769-p and cell proliferation in vitro. BALB/c mice implanted with Renca cells were divided into 4 groups and administered orally by gavage with sunitinib, COX-2 inhibitor (celecoxib) monotherapy or combination, and PBS respectively...
December 2, 2016: Oncotarget
https://www.readbyqxmd.com/read/27916808/simultaneous-determination-of-four-tanshinones-by-uplc-tq-ms-and-their-pharmacokinetic-application-after-administration-of-single-ethanol-extract-of-danshen-combined-with-water-extract-in-normal-and-adenine-induced-chronic-renal-failure-rats
#8
Hong-Die Cai, Shu-Lan Su, Yonghui Li, Zhenhua Zhu, Jianming Guo, Yue Zhu, Sheng Guo, Dawei Qian, Jinao Duan
Salvia miltiorrhiza, one of the major traditional Chinese medicines, is commonly used and the main active ingredients-tanshinones-possess the ability to improve renal function. In this paper, the UPLC-TQ/MS method of simultaneously determining four tanshinones-tanshinone IIA, dihydrotanshinone I, tanshinone I, and cryptotanshinone-was established and applied to assess the pharmacokinetics in normal and chronic renal failure (CRF) rat plasma. The pharmacokinetics of tanshinones in rats were studied after separately intragastric administration of Salvia miltiorrhiza ethanol extract (SMEE) (0...
November 28, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27916422/pgc-1-alpha-interacts-with-microrna-217-to-functionally-regulate-breast-cancer-cell-proliferation
#9
Shaohui Zhang, Xinguo Liu, Jianming Liu, Heng Guo, Hongfeng Xu, Geng Zhang
BACKGROUND: In this study, we explored the functional mechanism of PPARg co-activator 1-alpha (PGC-1α) in regulating miR-217-mediated breast cancer development in vitro. METHODS: Dual-luciferase activity assay was applied to examine the binding of miR-217 on PGC-1α gene. Breast cancer cell lines, MCF-7 and MDA-MB-231 were infected by lentivirus to constitutively downregulate miR-217. Its regulation on PGC-1α expression was investigated by qRT-PCR and western blot...
January 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27910852/kaleidoscopic-imaging-patterns-of-complex-structures-fabricated-by-laser-induced-deformation
#10
Haoran Zhang, Fengyou Yang, Jianjie Dong, Lena Du, Chuang Wang, Jianming Zhang, Chuan Fei Guo, Qian Liu
Complex surface structures have stimulated a great deal of interests due to many potential applications in surface devices. However, in the fabrication of complex surface micro-/nanostructures, there are always great challenges in precise design, or good controllability, or low cost, or high throughput. Here, we present a route for the accurate design and highly controllable fabrication of surface quasi-three-dimensional (quasi-3D) structures based on a thermal deformation of simple two-dimensional laser-induced patterns...
December 2, 2016: Nature Communications
https://www.readbyqxmd.com/read/27898411/radioprotective-effects-of-heat-killed-mycobacterium-tuberculosis-in-cultured-cells-and-radiosensitive-tissues
#11
Yuanyuan Chen, Yang Xu, Jicong Du, Jiaming Guo, Xiao Lei, Jianguo Cui, Cong Liu, Ying Cheng, Bailong Li, Fu Gao, Jintao Ju, Jianming Cai, Yanyong Yang
BACKGROUND: Exposure to ionizing radiation (IR) often causes severe damage to radiosensitive tissues, which limits the use of radiotherapy in cancer patients. Novel safe and effective radioprotectant is urgently required. It has been reported toll like receptor 2 (TLR2) plays a critical role in radioresistance. In this study, we demonstrated the protective effects of Heat-Killed Mycobacterium tuberculosis (HKMT), a potent TLR2 agonist, against IR. METHODS: Cell survival and apoptosis were determined by CCK-8 assay and Annexin V assay, respectively...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27885452/the-zero-ischemia-index-zii-a-novel-criterion-for-predicting-complexity-and-outcomes-of-off-clamp-partial-nephrectomy
#12
Yaohui Li, Lin Zhou, Tingchang Bian, Zhuoyi Xiang, Yeqing Xu, Yanjun Zhu, Xiaoyi Hu, Shuai Jiang, Jianming Guo, Hang Wang
PURPOSES: Although several anatomical classification systems that aimed to standardize the description of renal tumors were previously reported, a special classification system is required to help predict the complexity and perioperative outcomes of off-clamp nephron-sparing surgery (NSS). We developed a novel criterion-zero ischemia index (ZII), aiming to help predict the perioperative outcomes after off-clamp NSS and guide patient selection. METHODS: We retrospectively evaluated 149 patients between June 2009 and July 2014 in our institution who underwent off-clamp NSS with available computed tomography images...
November 24, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27877008/detection-of-alk-translocation-in-non-small-cell-lung-carcinoma-nsclc-and-its-clinicopathological-significance-using-the-ventana-immunohistochemical-staining-method-a-single-center-large-scale-investigation-of-1-504-chinese-han-patients
#13
Lin Yang, Yun Ling, Lei Guo, Di Ma, Xuemin Xue, Bingning Wang, Junling Li, Jianming Ying
OBJECTIVE: The novel fully automated immunohistochemistry (IHC) assay-Ventana anaplastic lymphoma kinase (ALK)-D5F3 for screening ALK rearrangements has been approved by China's Food and Drug Administration in 2013, our previous study disclosed a highly specificity and sensitivity nearly 100%, and its efficacy needs to be evaluated in a large cohort of primary lung adenocarcinoma patients, and to compare clinicopathological features with ALK (+) and ALK (-) lung adenocarcinoma. METHODS: A total of 1,504 consecutive surgical lung adenocarcinoma cases of Chinese Han population were collected and re-diagnosed according to the 2011 multidisciplinary classification of lung adenocarcinoma...
October 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/27861865/mechanical-stress-regulates-bone-metabolism-through-micrornas
#14
REVIEW
Yu Yuan, Lingli Zhang, Xiaoyang Tong, Miao Zhang, Yilong Zhao, Jianming Guo, Le Lei, Xi Chen, Jennifer Tickner, Jiake Xu, Jun Zou
There are many lines of evidence indicating that mechanical stress regulates bone metabolism and promotes bone growth. BMP, Wnt, ERK1/2, and OPG/RANKL are the main molecules thought to regulate the effects of mechanical loading on bone formation. Recently, microRNAs were found to be involved in bone cell proliferation and differentiation, regulating the balance of bone formation and bone resorption. Emerging evidence indicates that microRNAs also participate in mechanical stress-mediated bone metabolism, and is associated with disuse induced osteoporosis or osteopenia...
November 15, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27836301/burnout-is-associated-with-poor-recovery-of-physical-performance-and-low-quality-of-life-in-patients-after-their-first-episode-of-acute-coronary-syndrome-a-hospital-based-prospective-cohort-study
#15
Min Zhang, Yunke Shi, Yanfei Yang, Ling Liu, Jianming Xiao, Tuo Guo, Jian Li
OBJECTIVES: "Burnout" is an affective response that is different to depression or anxiety. Studies on the relationship between burnout and physical recovery after acute coronary syndrome (ACS) in the long-term are lacking, hence the rationale of this study. METHODS: Participants were patients after their first onset of ACS divided into the high burnout group (HBG) and low burnout group (LBG) based on the upper quartile of their burnout score on the day before discharge...
January 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27821813/enrichment-of-c5a-c5ar-axis-predicts-poor-postoperative-prognosis-of-patients-with-clear-cell-renal-cell-carcinoma
#16
Wei Xi, Li Liu, Jiajun Wang, Yu Xia, Qi Bai, Ying Xiong, Yang Qu, Qilai Long, Jiejie Xu, Jianming Guo
Anaphylatoxin C5a and its receptor C5aR on cancer cells constitute a vital axis to cancer progression. In this study, we measured C5aR level by immunohistochemistry in the same cohort of our previous C5a research, and C5a-C5aR axis status was determined by synthesizing C5a and C5aR data. C5aR was an adverse independent prognostic factor for ccRCC patients. Kaplan-Meier analyses revealed the unique position of both C5a and C5aR high population in postoperative survival, based on which patients were then shunted into C5a-C5aR enriched and non-enriched groups...
November 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27783999/low-ccl-21-expression-associates-with-unfavorable-postoperative-prognosis-of-patients-with-metastatic-renal-cell-carcinoma
#17
Ying Xiong, Li Liu, Jiajun Wang, Wei Xi, Yu Xia, Qi Bai, Yang Qu, Qilai Long, Jiejie Xu, Jianming Guo
BACKGROUND: Chemokine (C-C motif) ligand 21 (CCL21), a ligand of the chemokine (C-C motif) receptor 7, has recently been identified as an immuno-based anti-cancer molecule for its dendritic cells and T lymphocytes chemoattractant function. The aim of this study was to investigate prognostic values of CCL21 expression in metastatic renal cell carcinoma patients treated with targeted therapy. METHODS: This study included 111 patients with metastatic renal cell carcinoma receiving targeted therapy...
October 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27774116/protective-effects-of-hydrogen-against-low-dose-long-term-radiation-induced-damage-to-the-behavioral-performances-hematopoietic-system-genital-system-and-splenic-lymphocytes-in-mice
#18
Jiaming Guo, Deyun Zhao, Xiao Lei, Hainan Zhao, Yanyong Yang, Pei Zhang, Pengfei Liu, Yang Xu, Meizhou Zhu, Hu Liu, Yuanyuan Chen, Yunhai Chuai, Bailong Li, Fu Gao, Jianming Cai
Molecular hydrogen (H2) has been previously reported playing an important role in ameliorating damage caused by acute radiation. In this study, we investigated the effects of H2 on the alterations induced by low-dose long-term radiation (LDLTR). All the mice in hydrogen-treated or radiation-only groups received 0.1 Gy, 0.5 Gy, 1.0 Gy, and 2.0 Gy whole-body gamma radiation, respectively. After the last time of radiation exposure, all the mice were employed for the determination of the body mass (BM) observation, forced swim test (FST), the open field test (OFT), the chromosome aberration (CA), the peripheral blood cells parameters analysis, the sperm abnormality (SA), the lymphocyte transformation test (LTT), and the histopathological studies...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27713173/dot1l-expression-predicts-adverse-postoperative-prognosis-of-patients-with-clear-cell-renal-cell-carcinoma
#19
Yang Qu, Li Liu, Jiajun Wang, Wei Xi, Yu Xia, Qi Bai, Ying Xiong, Qilai Long, Jiejie Xu, Jianming Guo
BACKGROUND: Disruptor of telomeric silencing 1-like (Dot1l), a histone methyltransferase that targets the histone H3 lysine 79 (H3K79), has been reported that its high expression is associated with various cancers, while the association between Dot1l expression and clear-cell renal cell carcinoma (ccRCC) is still unknown. PATIENTS AND METHODS: We retrospectively enrolled 282 patients with ccRCC undergoing nephrectomy from a single institution between 2005 and 2007, with a median follow-up of 99 months...
October 5, 2016: Oncotarget
https://www.readbyqxmd.com/read/27694945/genomic-prediction-contributing-to-a-promising-global-strategy-to-turbocharge-gene-banks
#20
Xiaoqing Yu, Xianran Li, Tingting Guo, Chengsong Zhu, Yuye Wu, Sharon E Mitchell, Kraig L Roozeboom, Donghai Wang, Ming Li Wang, Gary A Pederson, Tesfaye T Tesso, Patrick S Schnable, Rex Bernardo, Jianming Yu
The 7.4 million plant accessions in gene banks are largely underutilized due to various resource constraints, but current genomic and analytic technologies are enabling us to mine this natural heritage. Here we report a proof-of-concept study to integrate genomic prediction into a broad germplasm evaluation process. First, a set of 962 biomass sorghum accessions were chosen as a reference set by germplasm curators. With high throughput genotyping-by-sequencing (GBS), we genetically characterized this reference set with 340,496 single nucleotide polymorphisms (SNPs)...
October 3, 2016: Nature Plants
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