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https://www.readbyqxmd.com/read/28630620/cloud-model-based-artificial-immune-network-for-complex-optimization-problem
#1
Mingan Wang, Shuo Feng, Jianming Li, Zhonghua Li, Yu Xue, Dongliang Guo
This paper proposes an artificial immune network based on cloud model (AINet-CM) for complex function optimization problems. Three key immune operators-cloning, mutation, and suppression-are redesigned with the help of the cloud model. To be specific, an increasing half cloud-based cloning operator is used to adjust the dynamic clone multipliers of antibodies, an asymmetrical cloud-based mutation operator is used to control the adaptive evolution of antibodies, and a normal similarity cloud-based suppressor is used to keep the diversity of the antibody population...
2017: Computational Intelligence and Neuroscience
https://www.readbyqxmd.com/read/28630457/how-impaired-efficacy-happened-between-gancao-and-yuanhua-compounds-targets-and-pathways
#2
Jin-Gao Yu, Jianming Guo, Kevin Yue Zhu, Weiwei Tao, Yanyan Chen, Pei Liu, Yongqing Hua, Yuping Tang, Jin-Ao Duan
As recorded in Traditional Chinese Medicine (TCM) theory, Gancao (Glycyrrhizae Radix et Rhizoma) could weaken the pharmacological effect or increase the toxicity of Yuanhua (Genkwa Flos). However, the theory has been suspected due to lack of evidence. Here, we investigate whether Gancao could weaken Yuanhua's diuretic effect, if so, which chemicals and which targets may be involved. Results showed that Yuanhua exerted diuretic effect through down-regulating renal AQP 2, without electrolyte disturbances such as K(+) loss which has been observed as side-effect of most diuretics...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28619634/enhancement-of-siglec-8-expression-predicts-adverse-prognosis-in-patients-with-clear-cell-renal-cell-carcinoma
#3
Chenzhang Ou, Li Liu, Jiajun Wang, Siyuan Dai, Yang Qu, Ying Xiong, Wei Xi, Jiejie Xu, Jianming Guo
PURPOSE: Sialic acid-binding immunoglobulin-like lectins (siglecs) family has important functions in tumor progression. The purpose of our study is to figure out the correlation between the expression level of Siglec-8 and prognosis of patients with clear cell renal cell carcinoma (ccRCC), and then to predict the overall survival (OS) via a novel nomogram. MATERIALS AND METHODS: A group of patients (n = 267) histologically diagnosed with ccRCC from Zhongshan Hospital were included into our study...
June 12, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28609013/polydatin-alleviated-radiation-induced-lung-injury-through-activation-of-sirt3-and-inhibition-of-epithelial-mesenchymal-transition
#4
Kun Cao, Xiao Lei, Hu Liu, Hainan Zhao, Jiaming Guo, Yuanyuan Chen, Yang Xu, Ying Cheng, Cong Liu, Jianguo Cui, Bailong Li, Jianming Cai, Fu Gao, Yanyong Yang
Radiation-induced lung injury (RILI) is one of the most common and fatal complications of thoracic radiotherapy. It is characterized with two main features including early radiation pneumonitis and fibrosis in later phase. This study was to investigate the potential radioprotective effects of polydatin (PD), which was shown to exert anti-inflammation and anti-oxidative capacities in other diseases. In this study, we demonstrated that PD-mitigated acute inflammation and late fibrosis caused by irradiation. PD treatment inhibited TGF-β1-Smad3 signalling pathway and epithelial-mesenchymal transition...
June 13, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28574819/heat-killed-salmonella-typhimurium-hkst-protects-mice-against-radiation-in-tlr4-dependent-manner
#5
Yang Xu, Yuanyuan Chen, Hu Liu, Xiao Lei, Jiaming Guo, Kun Cao, Cong Liu, Bailong Li, Jianming Cai, Jintao Ju, Fu Gao, Yanyong Yang
It is urgently required to develop novel safe and effective radioprotectors to alleviate radiation damages. Recently, several toll like receptors (TLRs), including TLR2, TLR4, TLR5, TLR9, have been proved to exert protective effects against ionizing radiation. Due to different tissue-distribution and distinct functions of TLRs, we hypothesized that co-activation of multiple TLRs simultaneously may produce extensive and stronger radioprotective effects. In this study, we found the co-agonist of TLR2, TLR4 and TLR5, heat-killed Salmonella typhimurium (HKST) significantly inhibited radiation-induced cell apoptosis, increased cell survival and alleviated DNA damage...
May 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28562332/irf5-is-associated-with-adverse-postoperative-prognosis-of-patients-with-non-metastatic-clear-cell-renal-cell-carcinoma
#6
Qi Bai, Li Liu, Yu Xia, Jiajun Wang, Wei Xi, Yang Qu, Ying Xiong, Qilai Long, Jiejie Xu, Jianming Guo
BACKGROUND: IRF5 is one member of IRFs family, and is critical for host immunity and cell response. In the present study, we sought to search the clinical and prognostic value of IFR5 in patients with non-metastatic ccRCC. RESULTS: IRF5 proved to be an adverse independent prognostic factor for overall survival (p < 0.001) and recurrence free survival (p = 0.002). The newly built nomograms could give better prediction for overall survival and recurrence free survival in ccRCC patients...
May 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28462578/ameliorating-dyslipidemia-in-type-2-diabetic-patients-by-femoropopliteal-artery-plaque-resection-under-acute-inflammation-response
#7
Jianming Guo, Zhiwan Cai, Shuwen Zhang, Ying Liu, Yongquan Gu
No abstract text is available yet for this article.
April 28, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28380448/glibenclamide-a-diabetic-drug-prevents-acute-radiation-induced-liver-injury-of-mice-via-up-regulating-intracellular-ros-and-subsequently-activating-akt-nf-%C3%AE%C2%BAb-pathway
#8
Hu Liu, Shichao Wang, Zhao Wu, Ziyun Huang, Wei You Chen, Yanyong Yang, Jianguo Cui, Cong Liu, Hainan Zhao, Jiaming Guo, Pei Zhang, Fu Gao, Bailong Li, Jianming Cai
BACKGROUND: Acute radiation-induced liver injury is a limitation for hepatoma radiotherapy. Come so far the clinical treatments are insufficient. The effective, specific, low toxicity and novel drugs are in powerful need. Glibenclamide is a common hypoglycemic. Some studies have revealed its relation with intracellular reactive oxygen species, the crucial mediator to radiation injury. This study is aimed to investigate if glibenclamide could act on the acute radiation-induced liver injury...
June 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28339064/extracellular-matrix-metabolism-disorder-induced-by-mechanical-strain-on-human-parametrial-ligament-fibroblasts
#9
Jie Min, Bingshu Li, Cheng Liu, Wenjun Guo, Shasha Hong, Jianming Tang, Li Hong
Pelvic organ prolapse (POP) is a global health problem that may seriously impact the quality of life of the sufferer. The present study aimed to investigate the potential mechanisms underlying alterations in extracellular matrix (ECM) metabolism in the pathogenesis of POP, by investigating the expression of ECM components in human parametrial ligament fibroblasts (hPLFs) subject to various mechanical strain loads. Fibroblasts derived from parametrial ligaments were cultured from patients with POP and without malignant tumors, who underwent vaginal hysterectomy surgery...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28335440/profile-of-polyphenol-compounds-of-five-muscadine-grapes-cultivated-in-the-united-states-and-in-newly-adapted-locations-in-china
#10
Zheng Wei, Jianming Luo, Yu Huang, Wenfeng Guo, Yali Zhang, Huan Guan, Changmou Xu, Jiang Lu
Polyphenol compositions and concentrations in skins and seeds of five muscadine grapes (cv. "Noble", "Alachua", "Carlos", "Fry", and "Granny Val") cultivated in the United States (Tallahassee-Florida, TA-FL) and South China (Nanning-Guangxi, NN-GX and Pu'er-Yunnan, PE-YN) were investigated, using ultra performance liquid chromatography tandem triple quadrupole time-of-flight mass spectrometry (UPLC Triple TOF MS/MS). Fourteen ellagitannins were newly identified in these muscadine grapes. The grapes grown in NN-GX accumulated higher levels of ellagic acid, methyl brevifolin carboxylate, and ellagic acid glucoside in skins, and penta-O-galloyl-glucose in seeds...
March 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28303938/modulated-ch3nh3pbi3-xbrx-film-for-efficient-perovskite-solar-cells-exceeding-18
#11
Yongguang Tu, Jihuai Wu, Zhang Lan, Xin He, Jia Dong, Jinbiao Jia, Panfeng Guo, Jianming Lin, Miaoliang Huang, Yunfang Huang
The organic-inorganic lead halide perovskite layer is a crucial factor for the high performance perovskite solar cell (PSC). We introduce CH3NH3Br in the precursor solution to prepare CH3NH3PbI3-xBrx hybrid perovskite, and an uniform perovskite layer with improved crystallinity and apparent grain contour is obtained, resulting in the significant improvement of photovoltaic performance of PSCs. The effects of CH3NH3Br on the perovskite morphology, crystallinity, absorption property, charge carrier dynamics and device characteristics are discussed, and the improvement of open circuit voltage of the device depended on Br doping is confirmed...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28301473/%C3%AE%C2%BA-opioid-receptor-is-involved-in-the-cardioprotection-induced-by-exercise-training
#12
Xiao Geng, Honglin Zhao, Shumiao Zhang, Juan Li, Fei Tian, Na Feng, Rong Fan, Min Jia, Haitao Guo, Liang Cheng, Jincheng Liu, Wensheng Chen, Jianming Pei
The present study was designed to test the hypothesis that exercise training elicited a cardioprotective effect against ischemia and reperfusion (I/R) via the κ-opioid receptor (κ-OR)-mediated signaling pathway. Rats were randomly divided into four groups: the control group, the moderate intensity exercise (ME) group, the high intensity exercise (HE) group, and the acute exercise (AE) group. For the exercise training protocols, the rats were subjected to one week of adaptive treadmill training, while from the second week, the ME and HE groups were subjected to eight weeks of exercise training, and the AE group was subjected to three days of adaptive treadmill training and one day of vigorous exercise...
2017: PloS One
https://www.readbyqxmd.com/read/28293303/characteristics-of-glucose-metabolism-indexes-and-continuous-glucose-monitoring-system-cgms-in-patients-with-insulinoma
#13
Weijun Gu, Yixin Liu, Hongyan Liu, Guoqing Yang, Qinghua Guo, Jin Du, Nan Jin, Li Zang, Zhaohui Lv, Jianming Ba, Yiming Mu, Jingtao Dou
AIMS: Analyze the clinical applicability of glucose metabolism indexes and continuous glucose monitoring data on the qualitative diagnosis of insulinoma. METHODS: Involve 22 patients with insulinoma (insulinoma group), 11 patients with hypoglycemia (hypoglycemia group) and 31 people with normal glucose tolerance (control group). HbA1c, fasting blood glucose (FBG), insulin (FINS) and C-peptide (FCP) was tested. Using CGMS to monitor the blood glucose for three consecutive days and selecting the monitoring data of 24 h thereof, figuring out, with the aid of EasyGV Version 9...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28185445/a-comparative-study-of-percutaneous-atherectomy-for-femoropopliteal-arterial-occlusive-disease-experiences-in-160-patients
#14
Yongquan Gu, Mahmoud B Malas, Lixing Qi, Lianrui Guo, Jianming Guo, Hengxi Yu, Zhu Tong, Xixiang Gao, Jian Zhang, Zhonggao Wang
BACKGROUND: SiverHawk directional atherectomy has been used to treat more than 300 thousand cases of lower extremity atherosclerotic occlusive disease in the world since it was approved by FDA in 2003. This study to analyze the safety and effectiveness of symptomatic femoral popliteal atherosclerotic disease treated by directional atheroectomy (DA). METHODS: Clinical data of all consecutive patients treated with percutaneous atherectomy utilizing the SiverHawk plaque excision at one university hospital was retrospectively analyzed...
February 9, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28178948/low-ccl17-expression-associates-with-unfavorable-postoperative-prognosis-of-patients-with-clear-cell-renal-cell-carcinoma
#15
Ying Xiong, Li Liu, Yu Xia, Jiajun Wang, Wei Xi, Qi Bai, Yang Qu, Jiejie Xu, Jianming Guo
BACKGROUND: Chemokine (C-C motif) ligand 17 (CCL17) is a chemokine mainly produced by myeloid dendritic cells. It is a ligand for CC chemokine receptor 4 (CCR4) and CC chemokine receptor 8 (CCR8). The aim of this study was to investigate prognostic values of CCL17 expression in patients with clear cell renal cell carcinoma (ccRCC). METHODS: The study included 286 patients with ccRCC. CCL17 expression was analyzed by immunohistochemistry on tissue microarrays. Prognostic values of CCL17 expression and patients' clinical outcomes were evaluated...
February 8, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28169451/an-optimized-transurethral-catheterization-cystometry-in-mice-and-comparison-with-classic-suprapubic-catheterization-cystometry
#16
Zhuoyi Xiang, Yaohui Li, Tingchang Bian, Minke He, Yeqing Xu, Guomin Wang, Jianming Guo, Hang Wang
AIMS: The aim of this study is to establish an optimized, minimally invasive transurethral catheterization cystometry (TUCC) and a novel urethral pressure profile (UPP) measurement for mice. METHODS: The optimized TUCC and the UPP measurement were first established. This optimized TUCC was then performed in 16 anesthetized female mice and compared with the suprapubic catheterization cystometry (SCC) in parallel after suprapubic catheters implantation (SCI; on zero, third, and seventh day, respectively)...
February 7, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28122358/prognostic-role-of-n-acetylgalactosaminyltransferase-10-in-metastatic-renal-cell-carcinoma
#17
Li Liu, Ying Xiong, Wei Xi, Jiajun Wang, Yang Qu, Zhiyuan Lin, Xiang Chen, Jiaxi Yao, Jiejie Xu, Jianming Guo
BACKGROUND AND PURPOSE: A previous study demonstrated that GALNT10 affects the sensitivity of cancer cells to tyrosine kinase inhibitor (TKI) therapy. The aim of this study was to assess whether GALNT10 holds a prognostic role in metastatic renal cell carcinoma (mRCC) patients treated with TKI agents. RESULTS: GALNT10 had no statistical correlation with any other clinicopathological parameters except for route of gaining samples (P = 0.001) and Heng's risk stratification (P = 0...
February 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28114889/prognostic-value-of-cc-chemokine-receptor-seven-expression-in-patients-with-metastatic-renal-cell-carcinoma-treated-with-tyrosine-kinase-inhibitor
#18
Yu Xia, Li Liu, Ying Xiong, Qi Bai, Jiajun Wang, Wei Xi, Yang Qu, Jiejie Xu, Jianming Guo
BACKGROUND: CC-chemokine receptor seven (CCR7), a G-protein coupled receptor normally facilitating immune cells lymphatic homing, has recently been identified on several cancer cells in promoting invasion and lymphatic specific metastasis by mimicking normal leukocytes. As tyrosine kinase inhibitors for metastatic renal cell carcinoma (mRCC) mostly emphasized on vascular inhibition, whether the CCR7 expressing tumor cells with potential lymphatic invasion function could have an impact on mRCC patient's drug response and survival, was unknown...
January 23, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28094950/capillary-force-induced-cold-welding-in-silver-nanowire-based-flexible-transparent-electrodes
#19
Yuan Liu, Jianming Zhang, Heng Gao, Yan Wang, Qingxian Liu, Siya Huang, Chuan Fei Guo, Zhifeng Ren
Silver nanowire (AgNW) films have been studied as the most promising flexible transparent electrodes for flexible photoelectronics. The wire-wire junction resistance in the AgNW film is a critical parameter to the electrical performance, and several techniques of nanowelding or soldering have been reported to reduce the wire-wire junction resistance. However, these methods require either specific facilities, or additional materials as the "solder", and often have adverse effects to the AgNW film or substrate...
February 8, 2017: Nano Letters
https://www.readbyqxmd.com/read/28052014/met-overexpression-gene-amplification-and-relevant-clinicopathological-features-in-gastric-adenocarcinoma
#20
Jing Zhang, Lei Guo, Xiuyun Liu, Wenbin Li, Jianming Ying
This study was conducted to investigate the expression of MET in Chinese gastric adenocarcinoma cohort, the correlation between MET overexpression and clinical pathological features, HER2 expression and MET gene amplification. A total of 816 gastric adenocarcinoma patients were included and MET and HER2 immunohistochemical (IHC) staining were performed. IHC and dual-color silver in situ hybridization analysis were performed in the tissue microarrays, constructed from the 240 patients who were randomly selected...
February 7, 2017: Oncotarget
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