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https://www.readbyqxmd.com/read/29772246/preterm-birth-disrupts-cerebellar-development-by-affecting-granule-cell-proliferation-program-and-bergmann-glia
#1
Igor Y Iskusnykh, Randal K Buddington, Victor V Chizhikov
Preterm birth is a leading cause of long-term motor and cognitive deficits. Clinical studies suggest that some of these deficits result from disruption of cerebellar development, but the mechanisms that mediate cerebellar abnormalities in preterm infants are largely unknown. Furthermore, it remains unclear whether preterm birth and precocious exposure to the ex-utero environment directly disrupt cerebellar development or indirectly by increasing the probability of cerebellar injury, including that resulting from clinical interventions and protocols associated with the care of preterm infants...
May 14, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29771287/term-or-preterm-cesarean-section-delivery-does-not-lead-to-long-term-detrimental-consequences-in-mice
#2
Morgane Chiesa, Damien Guimond, Roman Tyzio, Alexandre Pons-Bennaceur, Natalia Lozovaya, Nail Burnashev, Diana C Ferrari, Yehezkel Ben-Ari
Epidemiological studies have provided contradictory data on the deleterious sequels of cesarean section (C-section) delivery and their links with developmental brain disorders such as Autism Spectrum Disorders. To gain better insight on these issues, we have now compared physiological, morphological, and behavioral parameters in vaginal, term, and preterm C-section delivered mice. We report that C-section delivery does not lead to long-term behavioral alterations though preterm C-section delivery modifies communicative behaviors in pups...
May 16, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29765129/intrauterine-smoke-exposure-deregulates-lung-function-pulmonary-transcriptomes-and-in-particular-insulin-like-growth-factor-igf-1-in-a-sex-specific-manner
#3
Stefan Dehmel, Petra Nathan, Sabine Bartel, Natalia El-Merhie, Hagen Scherb, Katrin Milger, Gerrit John-Schuster, Ali Oender Yildirim, Machteld Hylkema, Martin Irmler, Johannes Beckers, Bianca Schaub, Oliver Eickelberg, Susanne Krauss-Etschmann
Prenatal exposure to tobacco smoke is a significant risk-factor for airway disease development. Furthermore, the high prevalence of pregnant smoking women requires the establishment of strategies for offspring lung protection. Therefore, we here aimed to understand the molecular mechanism of how prenatal smoke exposure affects fetal lung development. We used a mouse model recapitulating clinical findings of prenatally exposed children, where pregnant mice were exposed to smoke until c-section or spontaneous delivery, and offspring weight development and lung function was monitored...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29760169/dysbiosis-of-maternal-and-neonatal-microbiota-associated-with-gestational-diabetes-mellitus
#4
Jinfeng Wang, Jiayong Zheng, Wenyu Shi, Nan Du, Xiaomin Xu, Yanming Zhang, Peifeng Ji, Fengyi Zhang, Zhen Jia, Yeping Wang, Zhi Zheng, Hongping Zhang, Fangqing Zhao
OBJECTIVE: The initial colonisation of the human microbiota and the impact of maternal health on neonatal microbiota at birth remain largely unknown. The aim of our study is to investigate the possible dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus (GDM) and to estimate the potential risks of the microbial shift to neonates. DESIGN: Pregnant women and neonates suffering from GDM were enrolled and 581 maternal (oral, intestinal and vaginal) and 248 neonatal (oral, pharyngeal, meconium and amniotic fluid) samples were collected...
May 14, 2018: Gut
https://www.readbyqxmd.com/read/29747664/adverse-effects-in-children-exposed-to-maternal-hiv-and-antiretroviral-therapy-during-pregnancy-in-brazil-a-cohort-study
#5
Adriane M Delicio, Giuliane J Lajos, Eliana Amaral, Fernanda Cavichiolli, Marina Polydoro, Helaine Milanez
BACKGROUND: Antiretroviral therapy (ART) in pregnancy was associated with a drastic reduction in HIV mother-to-child transmission (MTCT), although it was associated with neonatal adverse effects. The aim of this study was to evaluate the neonatal effects to maternal ART. METHODS: This study was a cohort of newborns from HIV pregnant women followed at the CAISM/UNICAMP Obstetric Clinic from 2000 to 2015. The following adverse effects were evaluated: anemia, thrombocytopenia, liver function tests abnormalities, preterm birth, low birth weight and congenital malformation...
May 10, 2018: Reproductive Health
https://www.readbyqxmd.com/read/29741516/the-influence-of-anesthetics-on-substantia-nigra-tyrosine-hydroxylase-expression-and-tau-phosphorylation-in-the-hypoxic-ischemic-near-term-lamb
#6
Melinda Barkhuizen, Fleur J P van Dijck, Reint K Jellema, Ruth Gussenhoven, Imke Engelbertink, Ralph van Mechelen, Jack P M Cleutjens, Matthias Seehase, Harry W M Steinbusch, Luc J Zimmermann, A W Danilo Gavilanes, Boris W Kramer
BackgroundGeneral anesthetics could protect key neurotransmitter systems, such as the dopaminergic system, from hypoxic-ischemic encephalopathy (HIE) by limiting excessive glutamatergic neurotransmission. However, anesthetics may adversely affect inflammation and tau phosphorylation.MethodsA near-term sheep model of HIE by umbilical cord occlusion (UCO) under anesthesia was used. The effect of propofol and isoflurane on the dopaminergic neurotransmitter phenotype in the substantia nigra (SN) was studied using tyrosine hydroxylase immunohistochemistry...
May 9, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29732978/the-effect-of-tranexamic-acid-on-preventing-post-partum-hemorrhage-due-to-uterine-atony-a-triple-blind-randomized-clinical-trial
#7
Mahvash Zargar, Roshan Nikbakht, Mahzad Ahmadi
BACKGROUND: Postpartum haemorrhage (PPH) is an important cause of early maternal death which needs to be controlled. OBJECTIVE: This study was designed to compare the effect of intravenous tranexsmic acid (TXA) and prostaglandin analogue on reducing PPH resulted from uterine atony in women undergoing C section or vaginal delivery. METHOD: A randomized, triple-blind, placebo-controlled study was conducted on 248 pregnant women with PPH due to uterine atony who were randomly assigned into two groups of TXA as the intervention group (n=124) and prostaglandin analogue as the control group (n=124)...
May 6, 2018: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/29731580/evaluation-of-biosafe-alternatives-as-xylene-substitutes-in-hematoxylin-and-eosin-staining-procedure-a-comparative-pilot-study
#8
Taneeru Sravya, Guttikonda Venkateswara Rao, Masabattula Geetha Kumari, Yerraguntla Vidya Sagar, Yeluri Sivaranjani, Kondamarri Sudheerkanth
Background: Xylene is synthetic hydrocarbon produced from coal tar known for its wide usage as universal solvent which has many hazardous effects. The aim of this study is to compare the efficacy of xylene-free hematoxylin and eosin (H and E) sections with conventional H and E sections. Materials and Methods: The study included ninety paraffin-embedded tissue blocks. Of these, sixty blocks were processed with sesame oil (xylene alternative) and thirty blocks with xylene...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29723237/association-of-maternal-nutrition-with-transient-neonatal-hyperinsulinism
#9
Mathilde Louvigne, Stephanie Rouleau, Emmanuelle Caldagues, Isabelle Souto, Yanis Montcho, Audrey Migraine Bouvagnet, Olivier Baud, Jean Claude Carel, Geraldine Gascoin, Regis Coutant
OBJECTIVE: The objective was to determine whether maternal nutritional factors are associated with transient neonatal hyperinsulinism (HI). DESIGN AND SETTING: Case control study in 4 French tertiary Obstetrics and Neonatology Departments between 2008 and 2015. METHODS: Sixty-seven mothers of neonates diagnosed with transient hyperinsulinism and 113 mothers of controls were included. The screening for hyperinsulinemic hypoglycemia in neonates was performed because of clinical symptoms suggestive of hypoglycemia or in the presence of conventional risk factors (small-for-gestational-age, prematurity, anoxo-ischemia, hypothermia, macrosomia, gestational diabetes)...
2018: PloS One
https://www.readbyqxmd.com/read/29714438/is-thermal-balloon-ablation-in-women-with-previous-cesarean-delivery-successful
#10
Zinatossadat Bouzari, Shahla Yazdani, Mojgan Naeimi Rad, Ali Bijani
Background/aim: Endometrial ablation is used to treat heavy menstrual bleeding in women who do not respond to standard therapy. This study aimed to compare treatment success in women with previous cesarean delivery and vaginal delivery who were subjected to thermal balloon ablation. Materials and methods: This cohort study enrolled women with symptoms of heavy menstrual bleeding who had major health problems and were considered as high-risk patients for hysterectomy. Patients were divided into two groups, vaginal delivery and cesarean section (C-section)...
April 30, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29693220/establishing-a-reproducible-murine-animal-model-of-single-anastomosis-duodenoileal-bypass-with-sleeve-gastrectomy-sadl-s
#11
Montana Laura, Lamon Mylene, Barrat Christophe, Hansel Boris, Magnan Christophe, Arapis Konstantinos
Single-anastomosis duodenoileal bypass with sleeve gastrectomy (SADI-S) is a simplified biliopancreatic diversion. The objective of this study was to develop a reproducible animal model for SADI-S. We used three techniques for duodenal exclusion and duodenoileal anastomosis: (a) surgical clip and side-to-side anastomosis, (b) ligation and side-to-side anastomosis and (c) sectioning the duodenum, closing the duodenal stump and end-to-side anastomosis. We recorded the surgical technique and complications for each method...
April 25, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29693036/factors-involved-in-selecting-the-birth-type-among-primiparous-women
#12
Ali Safari-Moradabadi, Azin Alavi, Asiyeh Pormehr-Yabandeh, Tasnim Eghbal Eftekhaari, Sakineh Dadipoor
BACKGROUND: Mortality and disability rates were reported to be respectively 2-3 and 5-10 times higher in C-sections compared to Vaginal delivery. OBJECTIVES: This study was aimed to explore the factors involved in selecting the birth type among primiparous women. METHODS: The present cross-sectional research was conducted on 220 primiparous women, who visited the health-care centers of Bandar Abbas. They were recruited in their first trimester of pregnancy with a simple randomized clustering method...
2018: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/29673899/it-s-about-time-cesarean-sections-and-neonatal-health
#13
Ana María Costa-Ramón, Ana Rodríguez-González, Miquel Serra-Burriel, Carlos Campillo-Artero
Cesarean sections have been associated in the literature with poorer newborn health, particularly with a higher incidence of respiratory morbidity. Most studies suffer, however, from potential omitted variable bias, as they are based on simple comparisons of mothers who give birth vaginally and those who give birth by cesarean section. We try to overcome this limitation and provide credible causal evidence by using variation in the probability of having a c-section that is arguably unrelated to maternal and fetal characteristics: variation by time of day...
March 27, 2018: Journal of Health Economics
https://www.readbyqxmd.com/read/29658763/the-birth-experiences-questionnaire-a-brief-measure-assessing-psychosocial-dimensions-of-childbirth
#14
Darby Saxbe, Katelyn Taline Horton, Ann Bryna Tsai
Childbirth is an important life event that has been understudied by psychologists. Parents may find birth to be stressful, painful, and frightening, or feel supported and calm. Birth experiences can be shaped both by preexisting psychological vulnerabilities and by medical events that occur during childbirth. The birth experience may influence both parent and child well-being, helping to shape the health of the new family. This paper introduces the Birth Experiences Questionnaire (BEQ), a brief 10-item measure designed to assess stress, fear, and partner support during birth...
March 2018: Journal of Family Psychology: JFP
https://www.readbyqxmd.com/read/29658374/hypercalcemic-crisis-in-third-trimenon-evaluating-the-optimal-treatment-strategy
#15
Julie Refardt, Patricia Farina, Irene Hoesli, Christian Meier
Hypercalcemia due to primary hyperparathyroidism during pregnancy is a rare condition and associated with increased morbidity and mortality for the mother and the unborn child. Whereas parathyroidectomy is favored during the second trimester, no clear recommendations exist for its management during the third trimenon. We here report the case of a 26-year-old woman in the 29th week of her first pregnancy, who was admitted to our clinic with hypertension, intra-uterine growth retardation and polyhydramnios. Severe hypercalcemia due to primary hyperparathyroidism was diagnosed (total calcium 3...
April 16, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29644040/a-rare-case-of-a-lingual-mass-in-a-neonate
#16
Laura Leach, Nico Jonas
A large lingual cyst was noted on the 22-week antenatal ultrasound, which grew in proportion to the foetus on serial imaging. An elective c-section was performed in view of possible airway obstruction, and the neonate initially required oxygen to maintain saturations. Aged 1 month, the baby developed significant breastfeeding difficulties secondary to rapid cyst and secondary tongue enlargement, completely filling the oral cavity. Fifteen millilitres of fluid were aspirated in clinic, resulting in reduction of tongue size and immediate improvement in feeding...
April 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29605266/gastrointestinal-mucosal-development-and-injury-in-premature-lambs-supported-by-the-artificial-placenta
#17
Jennifer S McLeod, Joseph T Church, Prathusha Yerramilli, Megan A Coughlin, Elena M Perkins, Raja Rabah, Robert H Bartlett, Alvaro Rojas-Pena, Joel K Greenson, Erin E Perrone, George B Mychaliska
BACKGROUND: An Artificial Placenta (AP) utilizing extracorporeal life support (ECLS) could revolutionize care of extremely premature newborns, but its effects on gastrointestinal morphology and injury need investigation. METHODS: Lambs (116-121days GA, term=145; n=5) were delivered by C-section, cannulated for ECLS, had total parenteral nutrition (TPN) provided, and were supported for 7days before euthanasia. Early and Late Tissue Controls (ETC, n=5 and LTC, n=5) delivered at 115-121days and 125-131days, respectively, were immediately sacrificed...
March 8, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29593993/fetal-primary-hydrothorax-with-spontaneous-resolution
#18
Vera Trocado, J P Coutinho-Borges, Mariana Carlos-Alves, Joaquim Santos, Paula Pinheiro
Fetal primary hydrothorax is a rare congenital anomaly with an estimated incidence of 1:10.000-15.000 pregnancies, with an unpredictable clinical course, ranging from spontaneous resolution to fetal death. We present a case of a unilateral fetal pleural effusion identified at 35th gestational week. A 37 year-old woman (G2P1) presented to our routine term pregnancy evaluation. The pregnancy had been otherwise uneventful. At ecographic evaluation a large anechogenic fluid collection was identified in the right fetal hemithorax, with atelectasis of right lung, displacing the heart and mediastinal structures to the contralateral hemithorax...
July 2017: Case Reports in Women's Health
https://www.readbyqxmd.com/read/29584783/regional-outcome-evaluation-program-p-re-val-e-reduction-of-inequality-in-access-to-effective-health-care-in-the-lazio-region-of-italy-2012-2015
#19
Martina Ventura, Danilo Fusco, Katia Bontempi, Paola Colais, Marina Davoli
BACKGROUND: Inequalities in health among groups of various socio-economic status (as measured by education, occupation, and income) constitute one of the main challenges for public health. Since 2006, the Lazio Regional Outcome Evaluation Program (P.Re.Val.E.), presents a set of indicators of hospital performance based on quality standards driven by strong clinical recommendations, and measures the variation in the access to effective health care for different population groups and providers in the Lazio Region...
2018: PloS One
https://www.readbyqxmd.com/read/29512813/evaluation-of-the-effectiveness-of-the-quadratus-lumborum-block-type-i-using-ropivacaine-in-postoperative-analgesia-after-a-cesarean-section-a-controlled-clinical-study
#20
Marcin Mieszko Mieszkowski, Ewa Mayzner-Zawadzka, Bułat Tuyakov, Marta Mieszkowska, Maciej Żukowski, Tomasz Waśniewski, Dariusz Onichimowski
OBJECTIVES: Quadratus Lumborum Block in contrast to Transversus Abdominis Plane Block contains a unique component which not only stops somatic pain but also inhibits visceral pain by spreading the local anesthetic to the paravertebral space. This study was designed to determine whether performing the Quadratus Lumborum Block type I in patients un-dergoing cesarean section would be associated with both decreased morphine consumption and decreased pain levels in the postoperative 48-hour period...
2018: Ginekologia Polska
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