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https://www.readbyqxmd.com/read/28728300/-evaluate-the-value-of-18-f-fdg-pet-ct-imaging-in-predicting-the-mutationsin-epidermal-growth-factor-receptor-in-lung-adenocarcinoma
#1
C Y Ding, W P Yang, Z Guo, J Sun, Y Y Li, T R Li
Objective: To investigate the value of maximum Standardized Uptake Value(SUVmax), Metabolic Tumor Volume (MTV) and Total Lesion Glycolysis (TLG) calculated from (18)F-FDG PET-CT in predicting the presence of epidermal growth factor receptor (EGFR) mutations in lung adenocarcinoma. Methods: We retrospectively reviewed 137 lung adenocarcinoma patients with EGFR mutations testing and pretreatment (18)F-FDG PET-CT. Receiver Operating Characteristic (ROC) curve analysis was performed to quantify the predictive value of SUVmax、MTV、TLG...
July 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28728219/-solitary-fibrous-tumor-hemangiopericytoma-of-central-nervous-system-a-clinicopathologic-analysis-of-71-cases
#2
X L Li, W W Fu, S Zhang, D Y Chen, Y P Chen, J Wu, X Y Liu, G P Li, S M Lin, S Luo, S S Cai, W Guo, X F Wang
Objective: As solitary fibrous tumor (SFT) and hemangiopericytoma (HPC) share the same molecular genetics features, the 2016 WHO classification of central nervous system (CNS) tumors had created the combined term SFT/HPC and assigns three grades. This study aims to investigate the clinicopathologic characteristics, diagnosis, differential diagnosis and prognosis of CNS SFT/HPC. Methods: Seventy-one cases of CNS SFT and HPC were retrospectively reclassified and studied. Histopathological, immunohistochemical and imaging features were analyzed...
July 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28727527/television-watching-and-telomere-length-among-adults-in-southwest-china
#3
Hong-Mei Xue, Qian-Qian Liu, Guo Tian, Li-Ming Quan, Yong Zhao, Guo Cheng
OBJECTIVES: To explore the independent associations of sedentary behavior and physical activity with telomere length among Chinese adults. METHODS: Data on total time of sedentary behavior, screen-based sedentary behavior (including television watching and computer or phone use), moderate to vigorous physical activity, and dietary intake of 518 adults in Chengdu, Guizhou, and Xiamen in China (54.25% women) aged 20 to 70 years were obtained between 2013 and 2015 through questionnaires...
July 20, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28726918/two-hybrid-lanthanide-complexes-exhibiting-a-large-magnetocaloric-effect-and-slow-magnetic-relaxation
#4
Song-De Han, Jin-Hua Li, Hao-Hao Liu, Guo-Ming Wang
Two isostructural lanthanide (Ln) hybrid complexes co-bridged by organic oxalate and inorganic hypophosphite, [Ln(oxa)(H2PO2)(H2O)2] (oxa = oxalate; Ln = Gd (1), Dy (2)), were solvothermally prepared with the goal of elucidating the role of a hybrid framework in the generation of novel molecular magnetic materials. The title compounds feature a two dimensional (2D) hybrid layer. The Ln(III) ions are octa-coordinated with distorted square antiprism geometry. The adjacent Ln(III) ions are co-bridged by hypophosphite and one type of oxalate ligand to form 1D hybrid chains, which are further linked by a second type of oxalate ligand to generate the resulting 2D framework...
July 20, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28726273/epigallocatechin-gallate-enhances-treatment-efficacy-of-oral-nifedipine-against-pregnancy-induced-severe-pre-eclampsia-a-double-blind-randomized-and-placebo-controlled-clinical-study
#5
D-D Shi, J-J Guo, L Zhou, N Wang
WHAT IS KNOWN AND OBJECTIVE: Oral nifedipine is commonly used to treat pre-eclampsia, one of the most severe complications during pregnancy, but its clinical efficacy is less than ideal. Epigallocatechin gallate (EGCG), a natural compound from green tea, could benefit cardiovascular health especially hypertension. We investigated the clinical efficacy of EGCG, when complemented with oral nifedipine, in treating pre-eclampsia. METHODS: A total of 350 pregnant women with severe pre-eclampsia were recruited and randomized to receive oral nifedipine, together with placebo (NIF+placebo) or EGCG (NIF+EGCG)...
July 20, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28723172/periodically-patterned-au-tio2-heterostructures-for-photoelectrochemical-sensor
#6
Limin Guo, Zhao Li, Kyle Marcus, Steven Navarro, Kun Liang, Le Zhou, Prabhu Doss Mani, Stephen J Florczyk, Kevin R Coffey, Nina Orlovskaya, Yong-Ho Sohn, Yang Yang
Periodically patterned Au nanorods in TiO2 nanocavities (Au NRs@TiO2) were fabricated via magnetron sputtering followed by a thermal dewetting process. This innovative Au NRs@TiO2 heterostructure was used as a plasmonic sensing platform for photoelectrochemical detection of glucose and lactose. This Au NRs@TiO2 patterned heterostructure possesses superior sensing properties to other Au nanoparticle-based sensors because (i) localized surface plasmon resonance (LSPR) generated at Au/TiO2 interfaces enhanced sensitivity of glucose (lactose) amperometric detection; (ii) periodic Au nanocrystals in TiO2 nanocavities accelerated charge separation and transfer rate, especially under monochromatic blue light irradiation; (iii) discrete planar architectures comprising Au NRs immobilized on TiO2 substrates significantly improved stability and reusability of the sensors...
May 26, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28722192/roles-of-fas-fasl-mediated-apoptosis-and-inhibin-b-in-the-testicular-dysfunction-of-rats-with-left-side-varicocele
#7
J Zhang, P P Jin, M Gong, J H Guo, K Fang, Q T Yi, R J Zhu
We investigated the role of the Fas/FasL signalling pathway and inhibin B expression in rats with an experimentally induced left-side varicocele. Forty-five Sprague Dawley (SD) male rats were randomly divided into three groups in average: control group, sham group and experimental group. The expression of inhibin B in the rat left testis was analysed at the mRNA and protein levels by reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting respectively. The expressions of Fas, FasL and caspase-3 in the left testis were measured by RT-PCR and immunofluorescence...
July 18, 2017: Andrologia
https://www.readbyqxmd.com/read/28719615/a-human-tissue-based-functional-assay-platform-to-evaluate-the-immune-function-impact-of-small-molecule-inhibitors-that-target-the-immune-system
#8
Cristina St Pierre, Jane Guo, John D Shin, Laura W Engstrom, Hyun-Hee Lee, Alan Herbert, Laura Surdi, James Baker, Michael Salmon, Sanjiv Shah, J Michael Ellis, Hani Houshyar, Michael A Crackower, Melanie A Kleinschek, Dallas C Jones, Alexandra Hicks, Dennis M Zaller, Stephen E Alves, Ravisankar A Ramadas
While the immune system is essential for the maintenance of the homeostasis, health and survival of humans, aberrant immune responses can lead to chronic inflammatory and autoimmune disorders. Pharmacological modulation of drug targets in the immune system to ameliorate disease also carry a risk of immunosuppression that could lead to adverse outcomes. Therefore, it is important to understand the 'immune fingerprint' of novel therapeutics as they relate to current and, clinically used immunological therapies to better understand their potential therapeutic benefit as well as immunosuppressive ability that might lead to adverse events such as infection risks and cancer...
2017: PloS One
https://www.readbyqxmd.com/read/28719344/protective-effect-of-edaravone-against-a%C3%AE-25-35-induced-mitochondrial-oxidative-damage-in-sh-sy5y-cells
#9
G-L Zhang, L Zhang, Y-Y Guo, Z-L Ma, H-Y Wang, T Li, J Liu, Y Du, L Yao, T-T Li, J-M Du
Amyloid-β (Aβ)-induced oxidative stress plays an important role in the pathogenesis of Alzheimer's disease (AD). Recent studies show that Aβ accumulation may lead to mitochondrial oxidative damage. In the present study, we investigated the protective effect of edaravone on mitochondrial damage in SH-SY5Y cells treated with Aβ25-35. SH-SY5Y cells were pre-treated with 20, 40 or 80 μM edaravone before treatment with 25 μM Aβ25-35. After 24h cell culture, cellular apoptosis, intracellular reactive oxygen species (ROS), mitochondrial membrane potential (ΔΨm), ATP levels and mitochondrial morphology were evaluated...
May 20, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28719243/genotyping-by-sequencing-based-genetic-analysis-of-african-rice-cultivars-and-association-mapping-of-blast-resistance-genes-against-magnaporthe-oryzae-populations-in-africa
#10
Emmanuel M Mgonja, Chan Ho Park, Houxiang Kang, Elias G Balimponya, Stephen Opiyo, Maria Bellizzi, Samuel K Mutiga, Felix Rotich, Veena Devi Ganeshan, Robert Mabagala, Clay Sneller, Jim Correll, Bo Zhou, Nicholas J Talbot, Thomas K Mitchell, Guo-Liang Wang
Understanding the genetic diversity of rice germplasm is important for the sustainable use of genetic materials in rice breeding and production. Africa is rich in rice genetic resources that can be utilized to boost rice productivity on the continent. A major constraint to rice production in Africa is rice blast, caused by the hemibiotrophic fungal pathogen Magnaporthe oryzae. In this report, we present the results of a genotyping-by-sequencing (GBS)-based diversity analysis of 190 African rice cultivars and an association mapping of blast resistance (R) genes and quantitative trait loci (QTLs)...
July 18, 2017: Phytopathology
https://www.readbyqxmd.com/read/28711716/impact-of-paroxetine-on-proximal-%C3%AE-adrenergic-receptor-signaling
#11
Shuchi Guo, Rhonda L Carter, Laurel A Grisanti, Walter J Koch, Douglas G Tilley
β-adrenergic receptors (βAR) regulate numerous functions throughout the body, however G protein-coupled receptor kinase (GRK)-dependent desensitization of βAR has long been recognized as a maladaptive process in the progression of various disease states. Thus, the development of small molecule inhibitors of GRKs for the study of these processes and as potential therapeutics has been at the forefront of recent research efforts. Via structural and biochemical analyses, the selective serotonin reuptake inhibitor (SSRI) paroxetine was identified as a GRK2 inhibitor that enhances βAR-dependent cardiomyocyte and cardiac contractility and reverses cardiac dysfunction and myocardial βAR expression in mouse models of heart failure...
July 12, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28710368/genome-wide-linkage-analysis-of-large-multiple-multigenerational-families-identifies-novel-genetic-loci-for-coronary-artery-disease
#12
Yang Guo, Fan Wang, Lin Li, Hanxiang Gao, Stephen Arckacki, Isabel Z Wang, John Barnard, Stephen Ellis, Carlos Hubbard, Eric J Topol, Qiuyun Chen, Qing K Wang
Coronary artery disease (CAD) is the leading cause of death, and genetic factors contribute significantly to risk of CAD. This study aims to identify new CAD genetic loci through a large-scale linkage analysis of 24 large and multigenerational families with 433 family members (GeneQuest II). All family members were genotyped with markers spaced by every 10 cM and a model-free nonparametric linkage (NPL-all) analysis was carried out. Two highly significant CAD loci were identified on chromosome 17q21.2 (NPL score of 6...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28708166/low-photon-count-based-digital-holography-for-quadratic-phase-cryptography
#13
Inbarasan Muniraj, Changliang Guo, Ra'ed Malallah, James P Ryle, John J Healy, Byung-Geun Lee, John T Sheridan
Recently, the vulnerability of the linear canonical transform-based double random phase encryption system to attack has been demonstrated. To alleviate this, we present for the first time, to the best of our knowledge, a method for securing a two-dimensional scene using a quadratic phase encoding system operating in the photon-counted imaging (PCI) regime. Position-phase-shifting digital holography is applied to record the photon-limited encrypted complex samples. The reconstruction of the complex wavefront involves four sparse (undersampled) dataset intensity measurements (interferograms) at two different positions...
July 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28702326/rev-erb-co-regulates-muscle-regeneration-via-tethered-interaction-with-the-nf-y-cistrome
#14
Ryan D Welch, Chun Guo, Monideepa Sengupta, Katherine J Carpenter, Natalie A Stephens, Stacy A Arnett, Marvin J Meyers, Lauren M Sparks, Steven R Smith, Jinsong Zhang, Thomas P Burris, Colin A Flaveny
OBJECTIVE: The loss of skeletal muscle mass and strength are a central feature of traumatic injury and degenerative myopathies. Unfortunately, pharmacological interventions typically fail to stem the long-term decline in quality of life. Reduced Rev-Erb-mediated gene suppression in cultured C2C12 myoblasts has been shown to stimulate myoblast differentiation. Yet the mechanisms that allow Rev-Erb to pleiotropically inhibit muscle differentiation are not well understood. In this study, we sought to elucidate the role of Rev-Erb in the regulation of muscle differentiation and regeneration in vivo...
July 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/28702022/preparing-the-gut-with-antibiotics-enhances-gut-microbiota-reprogramming-efficiency-by-promoting-xenomicrobiota-colonization
#15
Shou K Ji, Hui Yan, Tao Jiang, Chun Y Guo, Jing J Liu, Shuang Z Dong, Kai L Yang, Ya J Wang, Zhi J Cao, Sheng L Li
Gut microbiota plays multiple important roles in intestinal and physiological homeostasis, and using fecal microbiota transplantation (FMT) to reprogram gut microbiota has demonstrated promise for redressing intestinal and physiological disorders. This study tested the alterations in reprogramming efficiency caused by different gut preparation procedures and explored the associated underlying mechanisms. We prepared the guts of mice for FMT by administering one of the three most-clinically used pretreatments [antibiotics, bowel cleansing (BC) solution, or no pretreatment], and we found that preparing the gut with antibiotics induced a more efficient modification of the gut bacterial community than was induced by either of the other two pretreatment types...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28700032/lipoprotein-a-as-a-predictor-of-poor-collateral-circulation-in-patients-with-chronic-stable-coronary-heart-disease
#16
Y Fan, J-S Hu, F Guo, Z-B Lu, H Xia
As a mechanism compensating for obstructive coronary artery disease, coronary collateral circulation (CCC) has attracted cardiologists for a long time to explore its potential impact. In the present study, Chinese patients suffering from ≥95% coronary stenosis, as diagnosed by angiography, have been investigated for the correlation between CCC and lipoprotein(a) [Lp(a)] levels. A cohort of 654 patients was divided into four categories according to Rentrop grades 0, 1, 2, and 3. Lp(a) levels were divided into model 1, discretized with critical values of 33 and 66%, and model 2, discretized with a cutoff value of 30...
July 10, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28697340/stabilization-of-the-c-myc-protein-by-camkii%C3%AE-promotes-t-cell-lymphoma
#17
Ying Gu, Jiawei Zhang, Xiaoxiao Ma, Byung-Wook Kim, Hailong Wang, Jinfan Li, Yi Pan, Yang Xu, Lili Ding, Lu Yang, Chao Guo, Xiwei Wu, Jun Wu, Kirk Wu, Xiaoxian Gan, Gang Li, Ling Li, Stephen J Forman, Wing-Chung Chan, Rongzhen Xu, Wendong Huang
Although high c-Myc protein expression is observed alongside MYC amplification in some cancers, in most cases protein overexpression occurs in the absence of gene amplification, e.g., T cell lymphoma (TCL). Here, Ca(2+)/calmodulin-dependent protein kinase II γ (CAMKIIγ) was shown to stabilize the c-Myc protein by directly phosphorylating it at serine 62 (S62). Furthermore, CAMKIIγ was shown to be essential for tumor maintenance. Inhibition of CAMKIIγ with a specific inhibitor destabilized c-Myc and reduced tumor burden...
July 10, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28696753/evolution-of-the-reactor-antineutrino-flux-and-spectrum-at-daya-bay
#18
F P An, A B Balantekin, H R Band, M Bishai, S Blyth, D Cao, G F Cao, J Cao, Y L Chan, J F Chang, Y Chang, H S Chen, Q Y Chen, S M Chen, Y X Chen, Y Chen, J Cheng, Z K Cheng, J J Cherwinka, M C Chu, A Chukanov, J P Cummings, Y Y Ding, M V Diwan, M Dolgareva, J Dove, D A Dwyer, W R Edwards, R Gill, M Gonchar, G H Gong, H Gong, M Grassi, W Q Gu, L Guo, X H Guo, Y H Guo, Z Guo, R W Hackenburg, S Hans, M He, K M Heeger, Y K Heng, A Higuera, Y B Hsiung, B Z Hu, T Hu, E C Huang, H X Huang, X T Huang, Y B Huang, P Huber, W Huo, G Hussain, D E Jaffe, K L Jen, X P Ji, X L Ji, J B Jiao, R A Johnson, D Jones, L Kang, S H Kettell, A Khan, S Kohn, M Kramer, K K Kwan, M W Kwok, T J Langford, K Lau, L Lebanowski, J Lee, J H C Lee, R T Lei, R Leitner, J K C Leung, C Li, D J Li, F Li, G S Li, Q J Li, S Li, S C Li, W D Li, X N Li, X Q Li, Y F Li, Z B Li, H Liang, C J Lin, G L Lin, S Lin, S K Lin, Y-C Lin, J J Ling, J M Link, L Littenberg, B R Littlejohn, J L Liu, J C Liu, C W Loh, C Lu, H Q Lu, J S Lu, K B Luk, X Y Ma, X B Ma, Y Q Ma, Y Malyshkin, D A Martinez Caicedo, K T McDonald, R D McKeown, I Mitchell, Y Nakajima, J Napolitano, D Naumov, E Naumova, H Y Ngai, J P Ochoa-Ricoux, A Olshevskiy, H-R Pan, J Park, S Patton, V Pec, J C Peng, L Pinsky, C S J Pun, F Z Qi, M Qi, X Qian, R M Qiu, N Raper, J Ren, R Rosero, B Roskovec, X C Ruan, H Steiner, P Stoler, J L Sun, W Tang, D Taychenachev, K Treskov, K V Tsang, C E Tull, N Viaux, B Viren, V Vorobel, C H Wang, M Wang, N Y Wang, R G Wang, W Wang, X Wang, Y F Wang, Z Wang, Z Wang, Z M Wang, H Y Wei, L J Wen, K Whisnant, C G White, L Whitehead, T Wise, H L H Wong, S C F Wong, E Worcester, C-H Wu, Q Wu, W J Wu, D M Xia, J K Xia, Z Z Xing, J L Xu, Y Xu, T Xue, C G Yang, H Yang, L Yang, M S Yang, M T Yang, Y Z Yang, M Ye, Z Ye, M Yeh, B L Young, Z Y Yu, S Zeng, L Zhan, C Zhang, C C Zhang, H H Zhang, J W Zhang, Q M Zhang, R Zhang, X T Zhang, Y M Zhang, Y X Zhang, Y M Zhang, Z J Zhang, Z Y Zhang, Z P Zhang, J Zhao, L Zhou, H L Zhuang, J H Zou
The Daya Bay experiment has observed correlations between reactor core fuel evolution and changes in the reactor antineutrino flux and energy spectrum. Four antineutrino detectors in two experimental halls were used to identify 2.2 million inverse beta decays (IBDs) over 1230 days spanning multiple fuel cycles for each of six 2.9 GW_{th} reactor cores at the Daya Bay and Ling Ao nuclear power plants. Using detector data spanning effective ^{239}Pu fission fractions F_{239} from 0.25 to 0.35, Daya Bay measures an average IBD yield σ[over ¯]_{f} of (5...
June 23, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28696728/mode-specific-electronic-friction-in-dissociative-chemisorption-on-metal-surfaces-h_-2-on-ag-111
#19
Reinhard J Maurer, Bin Jiang, Hua Guo, John C Tully
Electronic friction and the ensuing nonadiabatic energy loss play an important role in chemical reaction dynamics at metal surfaces. Using molecular dynamics with electronic friction evaluated on the fly from density functional theory, we find strong mode dependence and a dominance of nonadiabatic energy loss along the bond stretch coordinate for scattering and dissociative chemisorption of H_{2} on the Ag(111) surface. Exemplary trajectories with varying initial conditions indicate that this mode specificity translates into modulated energy loss during a dissociative chemisorption event...
June 23, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28696436/reduced-trpc6-mrna-levels-in-the-blood-cells-of-patients-with-alzheimer-s-disease-and-mild-cognitive-impairment
#20
R Lu, J Wang, R Tao, J Wang, T Zhu, W Guo, Y Sun, H Li, Y Gao, W Zhang, C J Fowler, Q Li, S Chen, Z Wu, C L Masters, C Zhong, N Jing, Y Wang, Y Wang
Transient receptor potential canonical 6 (TRPC6) inhibits β-amyloid (Aβ) production. Hyperforin, the TRPC6 agonist, reduces Aβ levels and improves cognitive performance in Alzheimer's disease (AD) models. However, it's unknown whether TRPC6 expression is changed in AD patients. In this case-control study, we measured TRPC6 expression levels in the peripheral blood cells of four independent AD sets from five hospitals and one mild cognitive impairment (MCI) set from a local community (229 AD, 70 MCI, 40 Parkinson disease and 359 controls from China, total n=698) using quantitative real-time PCR assay...
July 11, 2017: Molecular Psychiatry
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