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https://www.readbyqxmd.com/read/29429158/-pleomorphic-and-dedifferentiated-leiomyosarcoma-a-clinicopathologic-analysis
#1
M Sun, J G Liu, Q Y Weng, L Yu, J Wang
Objective: To investigate the clinicopathologic features, differential diagnosis and biological behavior of pleomorphic leiomyosarcoma (PLMS) and dedifferentiated leiomyosarcoma (DLMS). Methods: Forty-nine cases were collected from November 2007 to December 2016, including eight that diagnosed at Fudan University Shanghai Cancer Center, and 41 consultation cases. The clinical findings and pathologic features were reviewed. Immunophenotype was obtained in 33 cases and follow-up information was available in 38 cases...
February 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29416094/traumatic-cataract-in-children-in-eastern-china-shanghai-pediatric-cataract-study
#2
Yu Du, Wenwen He, Xinghuai Sun, Yi Lu, Xiangjia Zhu
Traumatic cataract is a main cause of visual impairment in pediatric populations and is preventable. Awareness of the causes and consequences of pediatric eye trauma play roles in health education and prevention of blindness. We conducted a retrospective chart review based on 5-year clinical data of pediatric traumatic cataract cases treated at the Eye and Ear, Nose and Throat Hospital of Fudan University, Shanghai, China. Clinical features including demographic data, injury mechanism, and causative agents were analyzed...
February 7, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29408747/risk-factors-for-ovarian-involvement-in-young-and-premenopausal-endometrioid-endometrial-cancer-patients
#3
Jun Li, Qin Zhu, Bingyi Yang, Chengcheng Ning, Xiaoxia Liu, Xuezhen Luo, Xiaojun Chen
OBJECTIVE: This study aimed to investigate the incidence of ovarian malignant involvement in young and premenopausal endometrioid endometrial cancer and study the possible risk factors. METHODS: Premenopausal patients 45 years of age or younger with endometrioid endometrial cancer treated at the OB/GYN Hospital of Fudan University between 2009 and 2013 were identified. The incidence of ovarian malignant involvement in young and premenopausal endometrioid endometrial cancer patients were calculated and the possible risk factors were investigated...
January 31, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29397624/-retrospective-analysis-of-diagnosis-and-treatment-of-breast-cancer-in-pregnancy
#4
F W Wang, S M Fu, Y C Jin, X H Gong, H D Cheng, K J Wu
Objective: To investigate the principles of diagnosis and treatment of breast cancer during pregnancy. Methods: Clinical data of patients with breast cancer during pregnancy admitted to Obstetrics and Gynecology Hospital of Fudan University between January 2012 to July 2017 were analyzed retrospectively. A total of 17 patients were diagnosed with breast cancer in pregnancy, the median age was 32 years (range from 25 to 45 years old), pathological staging revealed 2 patient with stage 0, 1 with stage Ⅱa, 7 with stage Ⅱb, 1 with stage Ⅲa, 2 with stage Ⅲc, 4 with stage Ⅳ...
February 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29383582/trend-and-causes-of-neonatal-mortality-in-a-level-iii-children-s-hospital-in-shanghai-a-15-year-retrospective-study
#5
Xue-Lian Wang, Jin Wang, Lin Yuan, Wen-Jing Shi, Yun Cao, Chao Chen
BACKGROUND: To determine the trend and causes of neonatal mortality in a large level III neonatal intensive care unit in Shanghai during a 15-year period. METHODS: This is a retrospective, single-centered study. All neonates who died during the period from January 1, 1999 to December 31, 2013 at Children's Hospital of Fudan University were included. We extracted relevant clinical information from their medical records, analyzed neonatal mortality rate and the characteristics of these patients, and compared neonatal deaths between different periods and populations...
January 30, 2018: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/29352574/mismatch-repair-status-as-a-beneficial-predictor-of-fluorouracil-based-adjuvant-chemotherapy-for-pancreatic-cancer
#6
Dingkong Liang, Si Shi, Chen Liang, Qingcai Meng, Bo Zhang, Quanxing Ni, Jin Xu, Xianjun Yu
BACKGROUND: Prior studies have indicated that patients with colorectal cancer with deficient mismatch repair have particular clinicopathologic features that distinguish them from patients with tumors with proficient mismatch repair. However, the effect of the mismatch repair status on outcomes after adjuvant chemotherapy for pancreatic cancer is still unknown. METHODS: Pancreatic cancer patients who underwent R0 resection between January 2013 and December 2015 at Fudan University Shanghai Cancer Center were included in this study...
January 15, 2018: Surgery
https://www.readbyqxmd.com/read/29334560/proposed-modification-of-the-8th-edition-of-the-ajcc-staging-system-for-pancreatic-ductal-adenocarcinoma
#7
Si Shi, Jie Hua, Chen Liang, Qingcai Meng, Dingkong Liang, Jin Xu, Quanxing Ni, Xianjun Yu
OBJECTIVE: The aim of this study was to improve the 8th edition (8th) of the American Joint Committee on Cancer (AJCC) staging system for pancreatic ductal adenocarcinoma (PDAC). BACKGROUND: The new 8th AJCC staging system for PDAC was released in October, 2016, and will be applied in clinical practice in 2018. METHODS: Two large cohorts were included in this analysis. One consisted of 45,856 PDAC patients in the Surveillance, Epidemiology, and End Results (SEER) database (2004-2014), and the other consisted of 3166 PDAC patients in the Fudan University Shanghai Cancer Center (FUSCC) database (2005-2015)...
January 12, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29325268/-clinical-significance-of-targeting-drug-based-molecular-biomarkers-expression-in-ovarian-clear-cell-carcinoma
#8
M J Li, H R Li, X Cheng, R Bi, X Y Tu, F Liu, L H Chen
Objective: To assess the expression level of targeting drug-based molecular biomarkers in ovarian clear cell carcinoma (OCCC) tissues and its clinical significance. Methods: A total of 63 OCCC patients included 40 primary OCCC and 23 recurrent OCCC for secondary cytoreductive surgery (SCS), who had received primary surgeries at Fudan University Shanghai Cancer Center between January, 2008 and December, 2015 were enrolled, and immunohistochemistry SP method was used to test human epidermal growth factor receptor (EGFR), human epidermal growth factor receptor-2 (HER2), aurora kinase A (AURKA), breast cancer susceptibility gene 1 (BRCA1), BRCA2 and programmed death-ligand 1 (PD-L1)protein expression in paraffin-embedded tissues...
December 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29325264/-high-risk-factors-analysis-of-stillbirth
#9
Y Xiong, H X Xia, Y S Wang, X L Lin, T T Zhu, Y Zhao, X T Li
Objective: To explore the high risk factors of stillbirth. Methods: 176 cases of stillbirth were collected in the Obstetrics and Gynecology Hospital of Fudan University from January 1(st), 2010 to December 31(st), 2016. All cases were analyzed retrospectively, including general profile, high risk factors of stillbirth in different years and pregnancy periods. Results: (1) The incidence of stillbirth was 0.178%(176/98 785). Stillbirth occured mostly at 28-28(+6) gestational weeks (10.8%,19/176), and the second peak was 29-29(+6) weeks(10...
December 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29307052/prognostic-factors-in-chinese-patients-with-prostate-cancer-receiving-primary-androgen-deprivation-therapy-validation-of-japan-cancer-of-the-prostate-risk-assessment-j-capra-score-and-impacts-of-pre-existing-obesity-and-diabetes-mellitus
#10
Meng-Bo Hu, Tian Yang, Ji-Meng Hu, Wen-Hui Zhu, Hao-Wen Jiang, Qiang Ding
PURPOSE: Our aim was to determine the prognostic factors in Chinese patients with prostate cancer receiving primary androgen deprivation therapy (PADT), validate the Japan Cancer of the Prostate Risk Assessment (J-CAPRA) score, and investigate the impacts of pre-existing obesity and diabetes mellitus (DM). METHODS: The study enrolled Chinese patients diagnosed with prostatic adenocarcinoma and treated with bilateral orchiectomy as PADT at Huashan Hospital, Fudan University (Shanghai, China), from January 2003 to December 2015...
January 6, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29304855/prognostic-value-of-coagulation-tests-for-in-hospital-mortality-in-patients-with-traumatic-brain-injury
#11
Qiang Yuan, Jian Yu, Xing Wu, Yi-Rui Sun, Zhi-Qi Li, Zhuo-Ying Du, Xue-Hai Wu, Jin Hu
BACKGROUND: Coagulopathy is commonly observed after traumatic brain injury (TBI). However, it is not known whether using the standard independent predictors in conjunction with coagulation tests would improve their prognostic value. We determined the incidence of TBI-associated coagulopathy in patients with isolated TBI (iTBI), evaluated the prognostic value of coagulation tests for in-hospital mortality, and tested their predictive power for in-hospital mortality in patients with iTBI...
January 5, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29279451/epidemiology-of-respiratory-pathogens-in-children-with-lower-respiratory-tract-infections-in-shanghai-china-from-2013-to-2015
#12
Pengcheng Liu, Menghua Xu, Leiyan He, Liyun Su, Aimin Wang, Pan Fu, Lijuan Lu, Chuanqing Wang, Jin Xu
This study aimed to explore the epidemiology of pathogens in children who were hospitalized with lower respiratory tract infections (LRTIs) at the Children's Hospital of Fudan University, Shanghai, China. Children aged less than 18 years who were hospitalized with LRTIs were recruited from January 2013 to December 2015. Respiratory specimens were collected for the detection of common respiratory viruses, atypical bacteria and bacteria using current laboratory diagnostic tests. The epidemiological characteristics of the respiratory pathogens were analysed...
December 26, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29245363/nasopharyngeal-carcinoma-with-central-nervous-system-metastases-two-case-reports-and-a-review-of-the-literature
#13
Chunying Shen, Hongmei Ying, Xueguan Lu, Chaosu Hu
RATIONALE: Central nervous system (CNS) metastases are rarely seen in patients with nasopharyngeal carcinoma (NPC). PATIENT CONCERNS: Two NPC patients developed CNS metastases were collected in Fudan University Shanghai Cancer Center. The medical records were reviewed to document patients' characteristics, treatment, and outcomes. In addition, we also provide an overview of the literature concerning this scenario. DIAGNOSES: Both patients were staged T4N1M0 with pathologically confirmed CNS metastases from nasopharyngeal carcinoma...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29243948/shanghai-health-study-2001-2009-what-was-learned-about-benzene-health-effects
#14
Sherilyn A Gross, Dennis J Paustenbach
The Shanghai Health Study (SHS) was a large epidemiology study conducted as a joint effort between the University of Colorado and Fudan University in Shanghai, China. The study was funded by members of the American Petroleum Institute between 2001 and 2009 and was designed to evaluate the human health effects associated with benzene exposure. Two arms of the SHS included: an occupational-based molecular epidemiology study and several hospital-based case control studies. Consistent with historical literature, following sufficient exposure to relatively high airborne concentrations and years of exposure, the SHS concluded that exposure to benzene resulted in an increased risk of various blood and bone marrow abnormalities such as benzene poisoning, aplastic anemia (AA), myelodysplastic syndrome (MDS), and acute myeloid leukemia (AML)...
December 15, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/29235006/intrinsic-contact-between-t-and-n-classifications-in-resected-well-moderately-differentiated-locoregional-pancreatic-neuroendocrine-neoplasms
#15
Jin-Zhi Xu, Wen-Quan Wang, Shi-Rong Zhang, Hua-Xiang Xu, Chun-Tao Wu, Zi-Hao Qi, He-Li Gao, Quan-Xing Ni, Liang Liu, Xian-Jun Yu
BACKGROUND: The role of N classification is controversial in several prognostication systems proposed for pancreatic neuroendocrine neoplasms (pNENs). The widely accepted modified European Neuroendocrine Tumor Society (mENETS) system suggests this contradiction may be related to T classification. METHODS: Data were collected retrospectively from 981 patients in the Surveillance, Epidemiology, and End Results (SEER) database (1973-2012; cohort 1) and 140 patients from the Pancreatic Cancer Institute of Fudan University (2006-2016; cohort 2)...
December 12, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29228613/the-incidence-and-prognosis-of-nasopharyngeal-carcinoma-patients-with-family-history
#16
Yansu Wang, Chunying Shen, Xueguan Lu, Chaosu Hu
Purpose: Epidemiological data showed that nasopharyngeal carcinoma (NPC) was a regional malignancy. It suggested that genetic factor may play an important role in tumorigenesis of NPC. The aim was to investigate the incidence and the prognosis of NPC patients with family history. Methods: The clinical data of patients with NPC treated in Fudan University Shanghai Cancer Center from January 2008 to December 2012 were reviewed, and the patients with family history were selected...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29227800/assessment-of-the-neuropsychiatric-comorbidities-in-chinese-children-with-epilepsy-using-the-mini-kid-tool
#17
Taoli Li, Hao Zhou, Yijie Li, Chunpei Li, Yunjian Zhang, Yuanfeng Zhou, Yi Wang
This study aimed to assess neuropsychiatric comorbidities and analyze risk factors in Chinese children with epilepsy. Children with epilepsy aged between 6 and 16 years from the Children's Hospital of Fudan University were included. Children with asthma and typically developing children were matched for age and gender, and served as control groups. Neuropsychiatric disorders were assessed by interviewing the parents or guardians using the Mini International Neuropsychiatric Interview for children (MINI-KID) (parent version)...
November 24, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29224275/-clinicopathologic-study-of-infiltrating-epitheliosis-of-the-breast
#18
X L Xu, X Y Tu, R H Shui, Y F Cheng, B H Yu, W T Yang
Objective: To evaluate the morphological and immunohistochemical features of infiltrating epitheliosis and its differential diagnosis. Methods: Nine consultation and routine cases of infiltrating epitheliosis diagnosed from January 2015 to December 2016 in Fudan University Shanghai Cancer Center were collected. All tissues were formalin-fixed paraffin-embedded and routinely HE stained. The HE slides were reviewed. Immunohistochemical staining of CKpan, CK7, CK19, CK5/6, CK14, p63, SMMHC, Calponin, ER, PR, HER2, Ki-67 and S-100 protein was performed using Ventana BenchMark automated immunostainer...
December 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29223698/risk-factors-for-unsuccessful-office-based-endometrial-biopsy-a-comparative-study-of-office-based-endometrial-biopsy-pipelle-and-diagnostic-dilation-and-curettage-d-c
#19
Bingying Xie, Cuifeng Qian, Bingyi Yang, Chengcheng Ning, Xiaoying Yao, Yan Du, Yue Shi, Xuezhen Luo, Xiaojun Chen
STUDY OBJECTIVE: To determine the risk factors for Pipelle diagnostic failure, which might help health care providers to choose the appropriate protocol for endometrial evaluation individually. DESIGN: A single-center prospective study (Canadian Task Force II) SETTING: The Obstetrics and Gynecology Hospital of Fudan University PATIENTS: 466 patients with an indication for endometrial biopsy INTERVENTIONS: All patients received Pipelle and then diagnostic dilation and curettage (D&C)...
December 6, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29221180/pelvic-recurrence-after-definitive-surgery-for-locally-advanced-rectal-cancer-a-retrospective-investigation-of-implications-for-precision-radiotherapy-field-design
#20
Chao Li, Yinju Zhu, Tong Tong, Ye Xu, Yun Guan, Jingwen Wang, Huankun Wang, Ji Zhu
Background: To analyze the local distribution of pelvic recurrence after total mesorectal excision, with a view to simplifying the formulation of optimal individualized radiotherapy plans. Methods: We retrospectively investigated the data of 168 patients diagnosed with recurrent pelvic cancer treated at Fudan University Shanghai Cancer Center between January 2008 and December 2012. The following were collected depending on availability: operative report, histological report, specimen photographs, initial preoperative images, images confirming local recurrence, and clinical history...
November 10, 2017: Oncotarget
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