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https://www.readbyqxmd.com/read/29690706/-the-analysis-of-clinical-characteristics-and-disease-activity-in-ankylosing-spondylitis-patients-with-hyperuircemia
#1
X J Zhang, X M Cui, R Y Chen, H T Sun, J J Zhou, L D Jiang
Objective: to investigate the clinical characteristics and disease activity in ankylosing spondylitis (AS) patients with hyperuricemia. Method: Laboratory tests, magnetic resonance imaging, disease activity and functional index of AS patients from Fudan University Zhongshan Hospital were collected. T test, square test were applied to investigate the difference between AS patients with hyperuricemia and AS patients with normal serum uric acid in clinical characteristics and disease activity in AS patients. Result: Among all the AS patients, 23...
April 3, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29690665/-spindle-cell-lipoma-and-pleomorphic-lipoma-a-clinicopathologic-analysis-of-65-cases
#2
L H Tang, Q Y Lao, L Yu, J Wang
Objective: To investigate the clinical and pathological features of spindle cell lipoma (SCL) and pleomorphic lipoma (PL) with emphasis on differential diagnosis. Methods: Sixty-five cases of SCL/PL from the archive of Department of Pathology, Fudan University Shanghai Cancer Center, from August of 2006 to June of 2017, were included in the study. Immunohistochemistry by EnVision method, MDM2 gene amplifycation and DDIT3 gene translocation by fluorescence in situ hybridization(FISH) were detected and the literature was reviewed...
April 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29687289/analysis-of-predictive-factors-for-treatment-resistance-and-disease-relapse-in-takayasu-s-arteritis
#3
Ying Sun, Lili Ma, Huiyong Chen, Xiufang Kong, Peng Lv, Xiaomin Dai, Zongfei Ji, Chengde Yang, Shengming Dai, Lijun Wu, Yaohong Zou, Jiang Lin, Hongcheng Shi, Qiang Yu, Lindi Jiang
The objective of the study was to investigate the long-term treatment effects and predictive factors for treatment response and disease relapse for Takayasu's arteritis (TA). Eighty-one patients were recruited from the Department of Rheumatology, Zhongshan Hospital, Fudan University, between January 2009 and January 2015. The follow-up duration ranged from 6 to 36 months. Patients were divided into three groups: clinical remission (CR; n = 59); treatment-resistant (TR; n = 11); and disease relapse (DR; n = 11)...
April 23, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29673110/programmed-death-ligand-1-expression-in-gastric-cancer-correlation-with-mismatch-repair-deficiency-and-her2-negative-status
#4
Lei Wang, Qiongyan Zhang, Shujuan Ni, Cong Tan, Xu Cai, Dan Huang, Weiqi Sheng
Gastric cancer (GC) is one of the most common malignancies. Immunotherapy is a promising targeted treatment. The immune regulatory programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) axis has been used as a checkpoint target for immunotherapy. Currently, considerable discrepancies exist concerning the expression status of PD-L1 and its prognostic value in GC. We aimed to evaluate the expression rates of PD-L1 in GC, and further assess its relationship with mismatch repair (MMR), and human epidermal growth factor receptor 2 (HER2) status...
April 19, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29673085/association-of-serum-uric-acid-levels-with-primary-open-angle-glaucoma-a-5-year-case-control-study
#5
Shengjie Li, Mingxi Shao, Danhui Li, Binghua Tang, Wenjun Cao, Xinghuai Sun
PURPOSE: It has been hypothesised that uric acid (UA) has a protective effect against oxidative damage in the central nervous system. Therefore, we investigated serum UA concentrations in patients with primary open-angle glaucoma (POAG) and explored the relationship between serum UA concentration and glaucoma severity. METHODS: This prospective, cross-sectional, case-control study was conducted in 163 POAG patients and 103 normal controls. Clinical and demographic information was obtained from the medical data platform of the Eye & ENT Hospital of Fudan University, Shanghai, China...
April 19, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29626052/association-between-serum-lipids-concentration-and-patients-with-age-related-cataract-in-china-a-cross-sectional-case-control-study
#6
Shengjie Li, Danhui Li, Yudong Zhang, Jisen Teng, Mingxi Shao, Wenjun Cao
OBJECTIVE: Obesity and a high-fat diet have been found to be associated with an increased risk of age-related cataract (ARC). Thus, this study aimed to investigate whether serum lipid levels are associated with the incidence of ARC. DESIGN: Cross-sectional, case-control study. SETTING: EyeandENT Hospital of Fudan University, Shanghai, China. PARTICIPANTS: A total of 219 ARC (male=94, female=125) subjects and 218 (male=110, female=118) normal control subjects were recruited in this study...
April 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29620969/clinical-analysis-of-endoscopic-submucosal-dissection-for-the-synchronous-multiple-primary-early-cancers-in-esophagus-and-stomach-12-cases-report
#7
Qiang Shi, Di Sun, Shi-Lun Cai, Mei-Dong Xu, Zhi-Peng Qi, Bing Li, Li-Qing Yao, Yun-Shi Zhong, Ping-Hong Zhou
OBJECTIVE: With the improvement of endoscopic diagnosis, the discovery rate of the synchronous multiple primary early cancers in esophagus and stomach is gradually increased, while the traditional surgery bringing serious damages. Endoscopic submucosal dissection (ESD) has become the first treatment option of early cancer in the digestive tract partly. This study intends to explore the feasibility, safety, and effectiveness of ESD in the treatment of the synchronous multiple early gastric cancer or precancerous lesions in the esophagus and stomach...
April 5, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29609232/-clinical-significance-of-loop-electrosurgical-excisional-procedure-in-diagnosis-and-treatment-of-cervical-adenocarcinoma-in-situ-and-invasive-cervical-adenocarcinoma
#8
Y Song, Q Wang, L Sui, S J Gao
Objective: To evaluate the accuracy of colposcopic biopsy on diagnosis of cervical adenocarcinoma in situ (AIS) and the clinical significance of loop electrosurgical excisional procedure (LEEP) on diagnosis and treatment of AIS and invasive adenocarcinoma. Methods: All medical records of 193 patients diagnosed as AIS by colposcopic biopsy and (or) AIS or invasive adenocarcinoma diagnosed by LEEP conization from Jan. 2015 to Dec. 2016 in Obstetrics and Gynecology Hospital of Fudan University were retrospectively reviewed...
March 25, 2018: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29602981/population-pharmacokinetics-of-vancomycin-and-auc-guided-dosing-in-chinese-neonates-and-young-infants
#9
Yewei Chen, Dan Wu, Min Dong, Yiqing Zhu, Jinmiao Lu, Xiaoxia Li, Chao Chen, Zhiping Li
OBJECTIVES: To develop a population pharmacokinetic (PK) model for vancomycin in Chinese neonates and infants less than 2 months of age (young infants) with a wide gestational age range, in order to determine the appropriate dosing regimen for this population. METHODS: We performed a retrospective chart review of patients from the neonatal intensive care unit (NICU) at Children's Hospital of Fudan University to identify neonates and young infants treated with vancomycin from May 2014 to May 2017...
March 30, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29589142/prognostic-values-of-hematological-biomarkers-in-nasopharyngeal-carcinoma-patients-treated-with-intensity-modulated-radiotherapy
#10
Lulu Ye, Ronald Wihal Oei, Fangfang Kong, Tingting Xu, Chunying Shen, Xiaoshen Wang, Xiayun He, Lin Kong, Chaosu Hu, Hongmei Ying
PURPOSE: In this study, we evaluated the prognostic values of hematological biomarkers in primary nasopharyngeal carcinoma (NPC) patients receiving definitive intensity-modulated radiotherapy (IMRT). METHODS: There were 427 NPC patients enrolled between January 2010 and March 2013 at Fudan University Shanghai Cancer Center. Pre-treatment absolute neutrophil count (ANC), platelet count (APC), lymphocyte count (ALC), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were collected as prognostic biomarkers...
March 27, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29570259/prognostic-significance-of-the-dynamic-changes-of-systemic-inflammatory-response-in-metastatic-renal-cell-carcinoma
#11
Beihe Wang, Weijie Gu, Fangning Wan, Guohai Shi, Dingwei Ye
PURPOSE: To elucidate the prognostic value of systemic inflammatory response in patients with metastatic renal cell carcinoma (mRCC) who are treated with sunitinib, we evaluated the prognostic role of C-reactive protein (CRP) kinetics. This study also compared prognostic models containing CRP kinetics and neutrophil-to-lymphocyte ratio (NLR) kinetics. MATERIALS AND METHODS: A consecutive cohort of 94 patients with mRCC who were treated with sunitinib was retrospectively included from Fudan University Shanghai Cancer Center...
March 23, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29562416/-myocardial-revascularization-among-patients-with-severe-left-ventricular-dysfunction-a-comparison-between-on-pump-beating-heart-and-off-pump-coronary-artery-bypass-grafting
#12
J Q Shen, Q Ji, W J Ding, L M Xia, K Song, L Wei, Y X Sun, C S Wang
Objective: To evaluate the impacts of an on-pump beating-heart versus an off-pump coronary artery bypass grafting (CABG) technique for surgical revascularization on the early clinical outcomes in patients with a left ventricular ejection fraction (EF) of 35% or less. Methods: A total of 216 consecutive patients with an echocardiographic estimated EF of 35% or less who underwent non-emergency, primary, isolated CABG from January 2010 to December 2014 at Department of Cardiovascular Surgery, Zhongshan Hospital, Fudan University were included in this study and were divided into either an OBCAB group (patients who received on-pump beating-heart CABG surgery, n =88) or an OPCAB group (patients who received off-pump CABG surgery, n =128)...
April 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29541226/sox2-and-sox12-are-predictive-of-prognosis-in-patients-with-clear-cell-renal-cell-carcinoma
#13
Weijie Gu, Beihe Wang, Fangning Wan, Junlong Wu, Xiaolin Lu, Hongkai Wang, Yao Zhu, Hailiang Zhang, Guohai Shi, Bo Dai, Dingwei Ye
Sex-determining region Y-box protein (SOX) genes serve an important role in cancer growth and metastasis. The present study aimed to determine the predictive ability of SOX and associated genes identified through molecular network in clear cell renal cell carcinoma (RCC). A total of 505 patients with clear cell RCC from The Cancer Genome Atlas (TCGA) cohorts were collected in this study. The expression profile of SOX and associated genes were obtained from the TCGA RNAseq database. Clinicopathological characteristics, including age, gender, tumor grade, stage, laterality disease-free-survival and overall survival (OS) were collected...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29541163/the-utility-of-hba1c-combined-with-haematocrit-for-early-screening-of-gestational-diabetes-mellitus
#14
Kui Wu, Yan Cheng, Tingting Li, Ziwen Ma, Junxiu Liu, Qingying Zhang, Haidong Cheng
Aims: To evaluate the utility of glycated haemoglobin A1c (HbA1c) alone and in combination with haematocrit (HCT) for screening gestational diabetes mellitus (GDM) between 12-16 gestational weeks. Methods: This prospective study was carried out in the Obstetrics and Gynaecology Hospital of Fudan University from November 2014 to February 2015. In total, 690 pregnant women between 20 and 35 years old were included in this study. All subjects received a routine blood examination for HbA1c and HCT at 12-16 gestational weeks (gw) and a 75-g oral glucose tolerance test at 24-28 gw...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29534358/-lipofibromatosis-a-clinicopathological-analysis-of-eight-cases
#15
Q Y Lao, M Sun, L Yu, J Wang
Objective: To investigate the clinicopathological characteristics and differential diagnosis of lipofibromatosis. Methods: The clinicopathological features and immunohistochemical profiles in 8 cases of lipofibromatosis diagnosed at Fudan University Shanghai Cancer Center from January 2008 to June 2017 were studied. Molecular analysis of β-catenin mutation by Sanger sequencing, NTKR1 and ETV6 rearrangements by FISH were performed. The follow up information was evaluated and the literature was reviewed. Results: There were 4 males and 4 females with a median age of 1...
March 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29529885/palliative-chemotherapy-near-the-end-of-life-in-oncology-patients
#16
Zhe Zhang, Meng-Lei Chen, Xiao-Li Gu, Ming-Hui Liu, Wei-Wei Zhao, Wen-Wu Cheng
BACKGROUND: Although palliative chemotherapy during end-of-life (EOL) care is used to relieve symptoms in patients with metastatic cancer, chemotherapy may lead to more aggressive EOL care. We evaluated the use of and variables associated with chemotherapy at EOL. METHODS: This study included data from patients who died from advanced cancer and underwent palliative chemotherapy between April 2007 and May 2017 at the Department of Palliative Care of Fudan University, Shanghai Cancer Center...
January 1, 2018: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/29518828/-clinical-characteristics-of-human-recombination-activating-gene-1-mutations-in-8-immunodeficiency-patients-with-diverse-phenotypes
#17
G Yu, W J Wang, D R Liu, Z F Tao, X Y Hui, J Hou, J Q Sun, X C Wang
Objective: To investigate the clinical characteristics of 8 immunodeficiency cases caused by human recombination activating gene 1 (RAG1) mutations, and to explore the relationship among genotypes, clinical manifestations and immunophenotypes. Methods: Clinical data were collected and analyzed from patients with RAG1 mutations who visited the Department of Clinical Immunology, Children's Hospital of Fudan University between October 2013 and June 2017. The data included clinical manifestations, immunophenotypes and genotypes...
March 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29503397/identification-and-quantification-of-alkaloid-in-khr98-and-fragmentation-pathways-in-hplc-q-tof-ms
#18
Jiakun Long, Yang Wang, Chen Xu, Tingting Liu, Gengli Duan, Yingjia Yu
Uncaria rhynchophylla is woody climber plant distributed mainly in China and Japan, the stems and hooks of which can be collected as "Gou-Teng" for the treatment of hyperpyrexia, epilepsy and preeclampsia. Fudan University first manufactured KHR98, the extract of Uncaria rhynchophylla. In order to study the active components and structural information of KHR98, we established a high- performance liquid chromatography (HPLC) coupled with quadrupole time-of-flight mass spectrometry (Q-TOF-MS) method for rapid analysis of alkaloids...
March 2, 2018: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29492922/-safety-evaluation-on-initial-100-consecutive-procedures-of-self-pulling-and-latter-transected-esophagojejunostomy
#19
Hankun Hao, Jun Hong, Yaping Wang, Jian Wang, Yibing Bei, Luchun Hua
OBJECTIVE: To evaluate the feasibility and the short-term safety of self-pulling and latter transected esophagojejunostomy(SPLT) in totally laparoscopic total gastrectomy (TLTG). METHODS: One hundred patients with gastric cancer received TLTG-SPLT at General Surgery Department of Huashan Hospital (Fudan University) from June 2014 to January 2017(SPLT group). The clinicopathologic characteristics, surgical and postoperative outcomes were collected retrospectively and compared with the conventional group undergoing TLTG plus overlap or functional end-to-end anastomosis from October 2013 to December 2015...
February 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29492907/-clinical-research-status-of-laparoscopic-total-gastrectomy-in-china
#20
Fenglin Liu, Xinyu Qin
Many retrospective and cohort studies have shown that laparoscopic total gastrectomy(LTG) has advantages of less trauma, quicker recovery and better incision than open total gastrectomy, and is not inferior to laparotomy in safety and the short- and long-term outcomes, so it has been widely applied. However there is still a lack of high level evidence-based basis. At present, several prospective multicenter clinical studies are being carried out in China, Japan and South Korea which have high incidence of gastric cancer to demonstrate the safety and feasibility of LTG and evaluate its long-term outcomes as well...
February 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
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