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fudan university

Lei Cheng, Yuxia Zhang, Ying Gu, Chunmei Lu, Qing Liu, Hao Yuan
BACKGROUND: Supporting and involving the families of pre-term infants' in the discharge process provides them with confidence in caring for their infants at home. In an effort to facilitate families' readiness for discharge, the neonatal unit (NU) of the Children's Hospital of Fudan University has implemented a best practice project. OBJECTIVES: The aim of this project was to integrate the best available evidence on facilitating families' readiness for discharge into the nursing practice of the Children's Hospital of Fudan University...
September 2016: JBI Database of Systematic Reviews and Implementation Reports
Fei Hu, Jiayan Zhang, Shupeng Shi, Zhang Zhou
BACKGROUND: Febrile illness in young children usually indicates an underlying infection and is a cause of concern for parents and carers. It is very important that healthcare professionals know how to recognize fever, assess children with fever, treat children with fever and role of nurses and parents. This paper outlines a best practice implementation project on the management of fever in children in an emergency department. OBJECTIVES: To audit current practice of fever management for children in an emergency department and to implement strategies to standardize pediatric fever management based on evidence-based practice guidelines...
September 2016: JBI Database of Systematic Reviews and Implementation Reports
Jieyu Wang, Nan Jia, Qing Li, Chao Wang, Xiang Tao, Keqin Hua, Weiwei Feng
The aim of the present study was to determine risk factors associated with recurrence and survival in patients with grade 3 endometrioid endometrial carcinoma (G3EEC). A retrospective analysis of 117 patients with G3EEC, who were admitted to the Obstetrics and Gynecology Hospital of Fudan University between January 2000 and December 2011, was performed. The χ(2) test or Fisher's exact test were used for the comparison of categorical variables. Kaplan-Meier method was used for estimating recurrence-free survival (RFS), disease-specific survival (DSS) and overall survival (OS) rates...
October 2016: Oncology Letters
Aliya Alimujiang, Miao Mo, Ying Liu, Nai-Si Huang, Guangyu Liu, Wanghong Xu, Jiong Wu, Zhen-Zhou Shen, Zhimin Shao, Graham A Colditz
PURPOSE: The Great Chinese Famine afflicted almost all Chinese people between 1959 and 1961. No study has explicitly assessed the association between an exposure to Chinese Famine and risk of overall breast cancer and tumor subtype. We evaluated the unique historical environmental influences of famine exposure on breast cancer subtypes. METHODS: 16,469 Chinese women who were diagnosed with invasive breast cancer in the Fudan University Shanghai Cancer Center (FUSCC) from 1999 to 2014 were analyzed...
November 2016: Breast Cancer Research and Treatment
Dong Lin, Ting Ye, Longfei Ma, Longlong Shao, Zuodong Song, Shujun Jiang, Jiaqing Xiang
OBJECTIVE: To compare the safety and efficacy between three-field lymphadenectomy and normative Ivor-Lewis two-field lymphadenectomy for thoracic esophageal squamous cell carcinoma METHODS: Clinical data of 375 patients with thoracic esophageal squamous cell carcinoma who underwent three-field lymphadenectomy(3FL) or Ivor-Lewis two-field lymphadenectomy(2FL, Ivor-Lewis) in Fudan University Shanghai Cancer Center during 2013 were retrieved and collected from electronic medical record system...
September 25, 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Xue-Lian Li, Dan-Feng Du, Hua Jiang
The comparison of robotic and conventional laparoscopic hysterectomy and pelvic lymphadenectomy in gynecologic cancer still needs to be studied. In all, 98 consecutive cases of patients with gynecologic cancer undergoing robot-assisted hysterectomy and pelvic lymphadenectomy, and another 98 consecutive cases of conventional laparoscopic hysterectomy and pelvic lymphadenectomy during the same period in the Obstetrics and Gynecology Hospital of Fudan University were included. The duration of the operation, blood loss, drainage during the first 24 h after the operation, total hospital stay, hospital stay after the operation, lymph nodes collected, perioperative complications, and the cost of each operation for both procedures were recorded...
September 26, 2016: Minimally Invasive Therapy & Allied Technologies: MITAT
Fang Shen, Xu-Yin Zhang, Chu-Yang Yin, Jing-Xin Ding, Ke-Qin Hua
STUDY QUESTION: What is the difference in vaginal-length gain and resumption of menstruation following cervicovaginal reconstruction using split-thickness skin (STS) graft versus small intestinal submucosa (SIS) graft for patients with congenital vaginal and cervical aplasia? SUMMARY ANSWER: No difference was found in the number of patients who resumed menstruation between the two groups; however, significantly greater vaginal-length gain was found in the STS group...
September 22, 2016: Human Reproduction
Jennifer A Collins, Bo Ping, Justin A Bishop, Syed Z Ali
BACKGROUND: CASTLE (carcinoma showing thymus-like differentiation) is a rare tumor (accounting for less than 0.15% of thyroid neoplasms) with most of the reported cases from Asia. Although this tumor is rare, distinguishing it from more aggressive neoplasms is critical because of its improved prognosis. To date, there have been limited studies on its cytomorphological features. Herein, we review the cytomorphological features of 10 fine-needle aspiration (FNA) cases of histologically confirmed CASTLE and discuss the findings in light of the current literature...
September 17, 2016: Acta Cytologica
X Cai, W-X Qi, L Wang, Z Zhang
OBJECTIVE: Primary colorectal cancer (CRC) with signet-ring cell (SRC) component is a distinct tumor of colon and rectum, and its prognosis is very poor. Reliable markers to predict the poor clinical outcome of this subgroup cancer remains undetermined. Therefore, we perform this study to investigate the prognosis value of seven proteins in CRC with SRC component . PATIENTS AND METHODS: This study involved 117 patients diagnosed with CRC with SRC component between January 2008 and August 2015 at Fudan University Shanghai Cancer Center...
August 2016: European Review for Medical and Pharmacological Sciences
Qinghe Jing, Yating Tang, Dongjin Qian, Yi Lu, Yongxiang Jiang
PURPOSE: To evaluate the characteristics of the posterior corneal surface in patients with high myopia before cataract surgery. METHODS: We performed a cross-sectional study at the Eye and ENT Hospital of Fudan University, Shanghai, China. Corneal astigmatism and axial length were measured with a rotating Scheimpflug camera (Pentacam) and partial coherence interferometry (IOLMaster) in a high-myopia study group of 167 eyes (axial length ≥ 26 mm) and a control group of 150 eyes (axial length > 20 mm and < 25 mm)...
2016: PloS One
Zhi-Gang Cao, Jun-Jing Li, Ling Yao, Yan-Ni Huang, Yi-Rong Liu, Xin Hu, Chuan-Gui Song, Zhi-Ming Shao
MicroRNA-454 (miR-454) has been reported to play an oncogenic or tumor suppressor role in most cancers. However, the clinical relevance of miR-454 in breast cancer remains unclear. We examined the expression of miR-454 in a tissue microarray containing 534 breast cancer specimens from female patients at Fudan University Shanghai Cancer Center using in situ hybridization (ISH). Of these, 250 patients formed the training set and the other 284 were the validation set. The relationship between miR-454 and clinical outcome was analyzed by the Kaplan-Meier method...
August 31, 2016: Oncotarget
Meng-Long Zhou, Lei Wang, Jia-Zhou Wang, Wang Yang, Ran Hu, Gui-Chao Li, Wei-Qi Sheng, Zhen Zhang
The widely validated Memorial Sloan Kettering Cancer Center (MSKCC) nomogram for gastric carcinoma (GC) was developed based on patients who received R0 resection only. The purpose of the current study was to assess the performance of this nomogram in Chinese patients who received postoperative chemoradiotherapy (CRT) after an R0 resection for GC. From 2006 to 2015, the clinical data of 150 eligible patients were retrospectively collected from the Fudan University Shanghai Cancer Center (FUSCC) and used for external validation...
August 29, 2016: Oncotarget
Yaqi Li, Lei Liang, Weixing Dai, Guoxiang Cai, Ye Xu, Xinxiang Li, Qingguo Li, Sanjun Cai
BACKGROUND: Colorectal cancer (CRC) is 3rd most commonly diagnosed cancer in males and the second in females. PD-1/PD-L1 axis, as an immune checkpoint, is up-regulated in many tumors and their microenvironment. However, the prognostic value of PD-1/PD-L1 in CRC remains unclear. METHODS: The Cancer Genome Atlas (TCGA) database (N = 356) and Fudan University Shanghai Cancer Center (FUSCC) cohort of patients (N = 276) were adopted to analyze the prognostic value of PD-L1 in colorectal tumor cells (TCs) and of PD-1 in tumor infiltrating cells (TILs) for CRC...
2016: Molecular Cancer
Ben Huang, Yang Feng, Shao-Bo Mo, San-Jun Cai, Li-Yong Huang
AIM: To hypothesize that in patients with colon cancer showing heavy intestinal wall invasion without distant metastasis (T4bN0-2M0), small tumor size would correlate with more aggressive tumor behaviors and therefore poorer cancer-specific survival (CSS). METHODS: We analyzed T4bN0-2M0 colon cancer patients in the Surveillance, Epidemiology and End Results (SEER) database. A preliminary analysis of T4bN0-2M0 colon cancer patients at the Fudan University Shanghai Cancer Center is also presented...
August 7, 2016: World Journal of Gastroenterology: WJG
Xiaoli Zhu, Qianming Bai, Yongming Lu, Peng Qi, Jianhui Ding, Jialei Wang, Xiaoyan Zhou
BACKGROUND: The rare epidermal growth factor receptor (EGFR) mutation S768I has only been reported sporadically in patients with lung adenocarcinoma (AC). OBJECTIVE: This study aimed to investigate the prevalence of the S768I mutation in Chinese patients with lung AC and to retrospectively analyze the response of S768I mutants to tyrosine kinase inhibitors (TKIs). PATIENTS AND METHODS: A total of 6698 tissue specimens of lung AC were collected from the Department of Pathology of Shanghai Cancer Center of Fudan University between 2013 and 2015 and screened for EGFR mutations...
August 18, 2016: Targeted Oncology
Huahua Liu, Yu Shi, Yuting Shi, Ruiping Hu, Hong Jiang
BACKGROUND: Dysphagia, or difficulty in swallowing, is a serious and life-threatening medical condition that affects a significant number of individuals with acute neurological conditions such as stroke. Nurses, who are available to patients 24 hours a day in hospital are in an ideal position to identify individuals with swallowing difficulties and initiate interventions that may prevent further complications until a formal assessment can be undertaken. OBJECTIVES: The aim of this evidence implementation project was to improve nursing management of dysphagia in acute stroke patients and prevent the occurrence of aspiration in patients admitted to the neurology ward of Huashan Hospital, Fudan University, Shanghai...
July 2016: JBI Database of Systematic Reviews and Implementation Reports
Huang Zhe
BACKGROUND: Constipation is one of the most common symptoms experienced by patients with advanced progressive illness. If constipation is not proactively managed, patients can experience negative consequences, such as anorexia, nausea, bowel impaction or bowel perforation, all of which can have an impact on quality of life. The prevention and management of constipation is an essential component of oncology nursing practice and should include evidence-based interventions. OBJECTIVES: The aim of this project was to integrate the available evidence of assessment and management of constipation into clinical practice, and implement strategies to improve compliance with evidence-based practice...
May 2016: JBI Database of Systematic Reviews and Implementation Reports
Lingli Gu, Jing Li
BACKGROUND: Chemotherapy-induced nausea and vomiting (CINV) are considered to be two of the most distressing side-effects of chemotherapy. They have a negative impact on a patient's quality of life and can influence the continuance of treatment. Owing to the lack of effective management of CINV, regular assessment and management of CINV is recommended for patients undergoing chemotherapy. AIMS/OBJECTIVES: The aim of this project was to integrate the available evidence on the assessment and management of CINV into practice, and implement strategies to improve compliance with evidence-based practice...
March 2016: JBI Database of Systematic Reviews and Implementation Reports
Y Cheng, Z J Lu, X G Yan, J He, G F Yan, X D Cai, W J Shen, A L Jin, G P Lu
OBJECTIVE: To study the complications occurred in the process of venoarterial extracorporeal membrane oxygenation (VA-EMCO) in critically ill children. METHOD: To analyze retrospectively 25 children who were admitted to PICU of Children's Hospital of Fudan University from December 2011 to December 2015. They were all treated with VA-ECMO with incision and catheterization in right internal carotid artery and jugular vein. Complications were recorded during ECMO process...
August 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Renjie Wang, Xiaoji Ma, Yaqi Li, Yiping He, Dan Huang, Sanjun Cai, Junjie Peng
PURPOSE: Signet ring cell carcinoma (SRCC) is rare. The aim of this study is to understand the clinicopathological features and identify the possible prognostic factors in colorectal SRCC. METHODS: Patients with SRCC who underwent primary lesion resection at Fudan University Shanghai Cancer Center from September 2008 to July 2014 were retrospectively analyzed. Patient's gender, age, tumor location, depth of invasion, lymph node metastasis, synchronous distant metastasis, perineural invasion, lymphovascular invasion, and E-cadherin expression were studied with prognosis, and the correlation between E-cadherin expression and clinicopathological features were analyzed...
2016: PloS One
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