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JOURNAL ARTICLE
Yi Cheng, Huiping Wang, Tian-Wen Jiang, Xinyao Guo, Felix Kwofie, Huaneng Su, Lindiwe Khotseng, Weifeng Zeng, Ying Zhang, Yujing Liu, Wen-Bin Cai, Shuangyin Wang
PtRu alloys have been recognized as the state-of-the-art catalysts for the methanol oxidation reaction (MOR) in direct methanol fuel cells (DMFCs). However, their applications in DMFCs are still less efficient in terms of both catalytic activity and durability. Rare earth (RE) metals have been recognized as attractive elements to tune the catalytic activity, while it is still a world-class challenge to synthesize well-dispersed Pt-RE alloys. Herein, we developed a novel hydrogen-assisted magnesiothermic reduction strategy to prepare a highly dispersed carbon-supported lutetium-doped PtRu catalyst with ultrafine nanoclusters and atomically dispersed Ru sites...
April 12, 2024: ACS Applied Materials & Interfaces
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JOURNAL ARTICLE
Fuyi Li, Xudong Guo, Yue Bi, Runchang Jia, Miranda E Pitt, Shirui Pan, Shuqin Li, Robin B Gasser, Lachlan Jm Coin, Jiangning Song
The genome of Mycobacterium tuberculosis contains a relatively high percentage (10%) of genes that are poorly characterised because of their highly repetitive nature and high GC content. Some of these genes encode proteins of the PE/PPE family, which are thought to be involved in host-pathogen interactions, virulence, and disease pathogenicity. Members of this family are genetically divergent and challenging to both identify and classify using conventional computational tools. Thus, advanced in silico methods are needed to identify proteins of this family for subsequent functional annotation efficiently...
June 21, 2023: Computers in Biology and Medicine
#3
JOURNAL ARTICLE
Genlei Zhang, Dongjie Cao, Shiyu Guo, Yan Fang, Qi Wang, Sheng Cheng, Wansheng Zuo, Zhenzhen Yang, Peng Cui
Development of efficient and robust electrocatalysts for complete oxidation of ethanol is critical for the commercialization of direct ethanol fuel cells. However, the complete oxidation of ethanol suffers from poor efficiency due to the low C1 pathway selectivity. Herein, single-atomic Ir (Ir1 ) on hcp-PtPb/fcc-Pt core-shell hexagonal nanoplates (PtPb@PtIr1 HNPs) enclosed by Pt(110) surface with a 7.2% tensile strain is constructed to drive complete electro-oxidation of ethanol. Benefiting from the construction of Ir1 sites, the PtPb@PtIr1 HNPs exhibit a Faraday efficiency of 57...
July 24, 2022: Small
#4
JOURNAL ARTICLE
Xia-Jin Liu, Yi Li, Shu-Lan Su, Dan-Dan Wei, Hui Yan, Sheng Guo, Er-Xin Shang, Xiao-Dong Sun, Jin-Ao Duan
The inflorescence of Chrysanthemum morifolium Ramat., a well-known traditional Chinese herb, has been proved to have a certain inhibitory effect on some bacteria; however, its main components and acne bacteria inhibition effect remain to be elucidated. In this study, GC-MS was used to analyze the components of different flowering stages and different parts and to study the inhibitory effects of six essential oils on S. aureus and P. acnes and their alleviating effects on THP-1 cell inflammation. GC-MS combined with relative retention index method analyzed results stated that the 5 samples of C...
2022: Evidence-based Complementary and Alternative Medicine: ECAM
#5
JOURNAL ARTICLE
Daying Wu, Liwei Yu, Lei Guo, Shiquan Li, Xiaohua Yao, Youhua Yao, Xinyou Cao, Kunlun Wu, Xin Gao
Highland barley has a different composition and structure to other crops. It has higher contents of total polyphenol (TPC), total flavonoid (TFC) and β-glucan, which can be supplemented to improve the nutrition of wheat-flour-based food. In this study, the flours of three different grain-colored highland barley varieties Beiqing 6 (BQ), Dulihuang (DLH), and Heilaoya (HLY), were added to Jimai60 (JM, a wheat variety with medium gluten) wheat flour at different substitution levels to investigate their effects on the unextractable polymeric protein (UPP) content, micro-structure, rheological properties and mixing properties of dough, and the color, texture, flavor, and in vitro digestion of Chinese steam bread (CSB)...
April 10, 2022: Foods (Basel, Switzerland)
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JOURNAL ARTICLE
Graham Jm Hickey, Candice L Wike, Xichen Nie, Yixuan Guo, Mengyao Tan, Patrick J Murphy, Bradley R Cairns
Vertebrate embryos achieve developmental competency during zygotic genome activation (ZGA) by establishing chromatin states that silence yet poise developmental genes for subsequent lineage-specific activation. Here, we reveal the order of chromatin states in establishing developmental gene poising in preZGA zebrafish embryos. Poising is established at promoters and enhancers that initially contain open/permissive chromatin with 'Placeholder' nucleosomes (bearing H2A.Z, H3K4me1, and H3K27ac), and DNA hypomethylation...
January 4, 2022: ELife
#7
RANDOMIZED CONTROLLED TRIAL
(no author information available yet)
In this issue of JNO Drs. M. Tariq Bhatti and Mark L. Moster discuss the following 6 articles: Dinah Zur, Michaella Goldstein, Barequet D, Oron Y, Elkayam O, Karni A, Wilf-Yarkoni A, Regev K, Habot-Wilner Z. Susac's syndrome-A new ocular finding and disease outcome. Eye (Lond). 2021. doi: 10.1038/s41433-021-01464-7. Epub ahead of print.Durbant E, Radoi C, Garcia T, Denoyer A, Arndt C. Intravitreal triamcinolone injections in non-arteritic anterior ischemic optic neuropathy-A retrospective report. J Fr Ophtalmol...
December 1, 2021: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
#8
JOURNAL ARTICLE
Yan Fang, Dongjie Cao, Yan Shi, Shiyu Guo, Qi Wang, Genlei Zhang, Peng Cui, Sheng Cheng
Achieving high catalytic performance with high CO2 selectivity is critical for commercialization of direct ethanol fuel cells. Here, we report carbon-supported highly porous Pt2 Ir alloy nanocrystals (p-Pt2 Ir/C) for an ethanol oxidation reaction (EOR) that displays nearly 7.2-fold enhancement in mass activity and promotes antipoisoning ability and durability for the EOR as compared with the commercial Pt/C-JM. Moreover, the catalyst exhibits high CO2 selectivity, 3.4-fold at 0.65 V (vs. SCE) and 4.1-fold at 0...
July 16, 2021: Journal of Physical Chemistry Letters
#9
JOURNAL ARTICLE
Yi Huang, Menghua Xia, Yi Guo, Guohui Zhou, Yuanyuan Wang
PURPOSE: Most published methods directly achieve vessel membrane border detection on cross-sectional intravascular ultrasound (IVUS) images. The vascular structural continuity that exists in entire IVUS image sequences has been overlooked. However, this continuity can have a helpful role in the delineation of vessel membrane contours. To achieve the vessel membrane segmentation more effectively through employing this continuity, a strategy, referred to as multiangle reconstruction, segmentation and recovery (RSR), is proposed in this paper...
June 8, 2021: Medical Physics
#10
JOURNAL ARTICLE
Xingyi Guo, Weiqiang Lin, Wanqing Wen, Jeroen Huyghe, Stephanie Bien, Qiuyin Cai, Tabitha Harrison, Zhishan Chen, Conghui Qu, Jiandong Bao, Jirong Long, Yuan Yuan, Fangqin Wang, Mengqiu Bai, Goncalo R Abecasis, Demetrius Albanes, Sonja I Berndt, Stéphane Bézieau, D Timothy Bishop, Hermann Brenner, Stephan Buch, Andrea Burnett-Hartman, Peter T Campbell, Sergi Castellví-Bel, Andrew T Chan, Jenny Chang-Claude, Stephen J Chanock, Sang Hee Cho, David V Conti, Albert de la Chapelle, Edith Jm Feskens, Steven J Gallinger, Graham G Giles, Phyllis J Goodman, Andrea Gsur, Mark Guinter, Marc J Gunter, Jochen Hampe, Heather Hampel, Richard B Hayes, Michael Hoffmeister, Ellen Kampman, Hyun Min Kang, Temitope O Keku, Hyeong Rok Kim, Loic Le Marchand, Soo Chin Lee, Christopher I Li, Li Li, Annika Lindblom, Noralane Lindor, Roger L Milne, Victor Moreno, Neil Murphy, Polly A Newcomb, Deborah A Nickerson, Kenneth Offit, Rachel Pearlman, Paul D P Pharoah, Elizabeth A Platz, John D Potter, Gad Rennert, Lori C Sakoda, Clemens Schafmayer, Stephanie L Schmit, Robert E Schoen, Fredrick R Schumacher, Martha L Slattery, Yu-Ru Su, Catherine M Tangen, Cornelia M Ulrich, Franzel Jb van Duijnhoven, Bethany Van Guelpen, Kala Visvanathan, Pavel Vodicka, Ludmila Vodickova, Veronika Vymetalkova, Xiaolong Wang, Emily White, Alicja Wolk, Michael O Woods, Graham Casey, Li Hsu, Mark A Jenkins, Stephen B Gruber, Ulrike Peters, Wei Zheng
BACKGROUND AND AIMS: Susceptibility genes and the underlying mechanisms for the majority of risk loci identified by genome-wide association studies (GWAS) for colorectal cancer (CRC) risk remain largely unknown. We conducted a transcriptome-wide association study (TWAS) to identify putative susceptibility genes. METHODS: Gene-expression prediction models were built using transcriptome and genetic data from the 284 normal transverse colon tissues of European descendants from the Genotype-Tissue Expression (GTEx), and model performance was evaluated using data from The Cancer Genome Atlas (TCGA, n = 355)...
October 12, 2020: Gastroenterology
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JOURNAL ARTICLE
Menghua Xia, Wenjun Yan, Yi Huang, Yi Guo, Guohui Zhou, Yuanyuan Wang
Automatic extraction of the lumen-intima border (LIB) and the media-adventitia border (MAB) in intravascular ultrasound (IVUS) images is of high clinical interest. Despite the superior performance achieved by deep neural networks (DNNs) on various medical image segmentation tasks, there are few applications to IVUS images. The complicated pathological presentation and the lack of enough annotation in IVUS datasets make the learning process challenging. Several existing networks designed for IVUS segmentation train two groups of weights to detect the MAB and LIB separately...
July 2020: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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REVIEW
Hannes Ludewig, Samuel Molyneux, Scarlet Ferrinho, Kai Guo, Rosemary Lynch, Danai S Gkotsi, Rebecca Jm Goss
Over 5000 halogenated natural products have been reported so far, many of these arising from the marine environment. The introduction of a halogen into a molecule can significantly impact its bioavailability and bioactivity. More recently enzymatic halogenation has been used to enable late stage functionalisation through site-selective halogenation and cross-coupling. Halogenases are becoming increasingly valued tools. This review outlines the various classes of halogenases that have been discovered, and examines these from both a structural and a mechanistic perspective, reflecting upon the many recent advances in halogenase discovery...
June 30, 2020: Current Opinion in Structural Biology
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JOURNAL ARTICLE
Zhida Wang, Yuan Gan, Yilang Mai, Zhuoxin Lu, Yan Shi, Chang-Qing Guo, Hongyi Tan, Chang-Feng Yan
In this work, well-arrayed platinum (Pt) nanocubes (NCs), with precise control on the size and the spatial arrangement, are synthesized from a microemulsion overgrowth in a block copolymer (BC) nanotemplate. The nano-vials on this self-assembled BC template serve as microreactors for the reduction of the HCl/H2PtCl6 precursor and direct the ordered periodic arrangement of the reduced Pt nanoparticles (NPs). As the content of HCl increases from 0% to 25%, the Pt NPs evolve from quasi-spheres to NCs, for which the density functional theory (DFT) computation reveals that the different adsorption energies of Cl and HCl dominate this morphology transition...
May 25, 2020: Analytical Chemistry
#14
JOURNAL ARTICLE
Niankun Guo, Hui Xue, Amurisana Bao, Zihong Wang, Jing Sun, Tianshan Song, Xin Ge, Wei Zhang, Keke Huang, Feng He, Qin Wang
Vacancy defects of catalyst has been extensively studied and proven to be beneficial to various electrocatalytic reactions. However, it remains a great challenge to systematically study the effects of vacancy defects on the electrocatalytic reaction during electrochemical process. Herein, an ultra-stable three-dimensional PtCu nanowire networks (NNWs) with ultrafine size, self-supporting rigid structure, and Cu vacancy defects has been successfully developed. The vacancy defect-rich PtCu NNWs exhibits an outstanding performance for oxygen reduction reaction (ORR), in which the mass activity is 14...
April 23, 2020: Angewandte Chemie
#15
JOURNAL ARTICLE
Yi Huang, Wenjun Yan, Menghua Xia, Yi Guo, Guohui Zhou, Yuanyuan Wang
BACKGROUND AND OBJECTIVE: Segmenting vessel membranes and locating the calcific region in intravascular ultrasound (IVUS) images aid physicians in the diagnosis of atherosclerosis. However, the manual extraction of the media adventitia (MA)/lumen border and calcification location are cumbersome due to the excessive number of IVUS frames. Moreover, most existing (semi-)automatic detection methods cannot achieve both vessel membrane extraction and calcification location simultaneously, and they are unable to detect vessel membranes in IVUS frames from different acquisition systems...
January 15, 2020: Computer Methods and Programs in Biomedicine
#16
JOURNAL ARTICLE
Fumin Xue, Chao An, Lixiang Chen, Gang Liu, Feifei Ren, Xinhua Guo, Haibin Sun, Lu Mei, Xiangdong Sun, Jinpeng Li, Youcai Tang, Xiuli An, Pengyuan Zheng
BACKGROUND: Gastric cancer (GC) has high incidence and mortality worldwide. However, the underlying mechanisms that regulate gastric carcinogenesis are largely undefined. 4.1B is an adaptor protein found at the interface of membrane and the cytoskeleton. Previous studies demonstrated that 4.1B serves as tumor suppressor. RESULTS: We showed that 4.1B expression was decreased or lost in most GC patients. The expression pattern of it was tightly correlated with tumor size, TNM stage and overall survival (OS)...
September 6, 2019: Cell Communication and Signaling: CCS
#17
JOURNAL ARTICLE
Deming Gu, Qiyan Feng, Changsheng Guo, Song Hou, Jiapei Lv, Yan Zhang, Sheng Yuan, Xin Zhao
Antibiotics in manure, soil, wastewater, and groundwater samples from the livestock and poultry farms in Xuzhou City were investigated in the present study. The concentrations of antibiotics in all matrices varied greatly among farms. Total concentrations of fluoroquinolones and macrolides were much higher than those of sulfonamides in manures and soil samples. Total concentrations of antibiotics in wastewater of livestock farms were higher than those of poultry farm. Josamycin (JM) and tilmicosin (TIL) accounted for more than 74% of the nine macrolides in all groundwater samples...
September 5, 2019: Bulletin of Environmental Contamination and Toxicology
#18
JOURNAL ARTICLE
Menghua Xia, Wenjun Yan, Yi Huang, Yi Guo, Guohui Zhou, Yuanyuan Wang
The detection of the lumen and media-adventitia (MA) borders in intravascular ultrasound (IVUS) images is crucial for quantifying plaque burdens. The challenge of the segmentation work mainly roots in various artifacts in the image. Most of the published methods involve the establishment of complex models but do not behave well on images with artifacts. In this study, aiming at automatically delineating borders in IVUS frames acquired by 20 MHz ultrasound probes, we present a fuzzy clustering-initialized hierarchical level set evolution (FC-HLSE) method...
April 25, 2019: Computers in Biology and Medicine
#19
JOURNAL ARTICLE
Chunhong Li, Hui Ruan, Dengming Chen, Kejian Li, Donglin Guo, Bin Shao
A Ni-based alloy was heat treated by changing the temperature and ambient atmosphere of the heat treatment. Morphology, crystal structure, and physical performance of the Ni-based alloy were characterized via SEM, XRD, TEM, and PPMS. Results show that due to the heat treatment process, the grain growth of the Ni-based alloy and the removal of impurities and defects are promoted. Both the orientation and stress caused by rolling are reduced. The permeability and saturation magnetization of the alloy are improved...
July 2018: Microscopy Research and Technique
#20
JOURNAL ARTICLE
Yan Guo, Zhihui Duan, Yitao Jia, Chaoying Ren, Jian Lv, Peng Guo, Wujie Zhao, Bin Wang, Suqiao Zhang, Yaxing Li, Zhongxin Li
The present study aimed to evaluate the expression of human epidermal growth factor receptor (HER4) isoforms and their ligand neuregulin 1 (NRG1) isoforms in human primary colorectal cancer (CRC). The mRNA expression of HER4 isoforms JM-a, JM-b, CYT1 and CYT2, and their ligand isoforms NRG1 I, II and III in CRC tissues and adjacent normal tissues were quantified by reverse transcription-quantitative polymerase chain reaction analysis. Univariate analysis and logistic regression analysis were performed to analyze the association between HER4 and NRG1 expression and lymph node metastasis in CRC...
May 2018: Oncology Letters
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