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https://www.readbyqxmd.com/read/28110175/ketogenic-diet-therapy-for-epilepsy-during-pregnancy-a-case-series
#1
Elles J T M van der Louw, Tanya J Williams, Bobbie J Henry-Barron, Joanne F Olieman, Johannes J Duvekot, Marijn J Vermeulen, Natalja Bannink, Monique Williams, Rinze F Neuteboom, Eric H Kossoff, Coriene E Catsman-Berrevoets, Mackenzie C Cervenka
PURPOSE: Evaluation of ketogenic diet (KD) therapies for seizure control during pregnancy when safety and appropriate management become considerations. Until now, no information has been available on seizure reduction and human pregnancy related outcomes in women treated with KD therapies. METHOD: We describe two cases of pregnant women with epilepsy treated with KD therapy either as monotherapy (Case 1) or as adjunctive therapy (Case 2). RESULTS: Case 1: A 27 year old woman, gravida1, started the classic KD with medium chain triglyceride (MCT) emulsion and 75g carbohydrate-restriction, later reduced to 47g...
December 26, 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28110159/manganese-intake-is-inversely-associated-with-depressive-symptoms-during-pregnancy-in-japan-baseline-data-from-the-kyushu-okinawa-maternal-and-child-health-study
#2
Yoshihiro Miyake, Keiko Tanaka, Hitomi Okubo, Satoshi Sasaki, Shinya Furukawa, Masashi Arakawa
BACKGROUND: One epidemiological study in Canada has addressed the association between zinc intake and depressive symptoms during pregnancy while another epidemiological study in Korea has examined the association between iron intake and depressive symptoms during pregnancy. The present cross-sectional study in Japan examined the association between intake of zinc, magnesium, iron, copper, and manganese and depressive symptoms during pregnancy. METHODS: Study subjects were 1745 pregnant women...
January 15, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28109890/sunlight-damage-to-cellular-dna-focus-on-oxidatively-generated-lesions
#3
André Passaglia Schuch, Natália Cestari Moreno, Natielen Jacques Schuch, Carlos Frederico Martins Menck, Camila Carrião Machado Garcia
The routine and often unavoidable exposure to solar ultraviolet (UV) radiation makes it one of the most significant environmental DNA-damaging agents to which humans are exposed. Sunlight, specifically UVB and UVA, triggers various types of DNA damage. Although sunlight, mainly UVB, is necessary for the production of vitamin D, which is necessary for human health, DNA damage may have several deleterious consequences, such as cell death, mutagenesis, photoaging and cancer. UVA and UVB photons can be directly absorbed not only by DNA, which results in lesions, but also by the chromophores that are present in skin cells...
January 18, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28109821/calcium-pyrophosphate-deposition-disease-revealing-a-hypersensitivity-to-vitamin-d
#4
Pauline Baudart, Arnaud Molin, Johann Cesini, Glenville Jones, Martin Kaufmann, Marie Laure Kottler, Christian Marcelli
OBJECTIVE: Hypersensitivity to vitamin D (HVD) due to a loss of function mutation of the CYP24A1 gene, which encodes vitamin D catabolizing enzyme was initially described as a cause of acute hypercalcemia in children and chronic renal diseases in adults. METHODS: We describe the first case of a patient presenting a calcium pyrophosphate deposition disease (CPDD) revealing a HVD. RESULTS: An abnormality of phospho-calcic metabolism was discovered during the course of an etiological workup for CPDD in a 52-year-old patient...
January 18, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28109593/apparent-ruminal-synthesis-of-b-vitamins-in-lactating-dairy-cows-fed-diets-with-different-forage-to-concentrate-ratios
#5
M Seck, J A Voelker Linton, M S Allen, D S Castagnino, P Y Chouinard, C L Girard
Effects of the forage-to-concentrate ratio on apparent ruminal synthesis of thiamine, riboflavin, niacin, vitamin B6, folates, and vitamin B12 were evaluated in an experiment using 14 ruminally and duodenally cannulated Holstein cows. The experiment was a crossover design with two 15-d treatment periods and a 14-d preliminary period in which cows were fed a diet intermediate in composition between the treatment diets. Treatments were diets containing low-forage (44.8% forage, 32.8% starch, 24.4% neutral detergent fiber) or high-forage (61...
January 18, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28109541/anaemia-as-an-independent-key-risk-factor-for-major-haemorrhage-in-patients-treated-with-vitamin-k-antagonists-results-of-the-score-prospective-cohort
#6
Nora Zenati, Yoann Gaboreau, Cynthia Brousseau Provencher, Pierre Albaladejo, Jean Luc Bosson, Gilles Pernod
INTRODUCTION: Risk scores for the prediction of haemorrhage are poorly predictive of major bleeding. The aim of this study was to refine the estimation of bleeding risk by identifying one or several parameters of prognostic significance among these algorithms. MATERIALS AND METHODS: The SCORE study was a prospective, multicentre cohort study conducted in France in 2009-2010. Patients were eligible if they had received vitamin K antagonist (VKA) for any therapeutic indication for at least 3months...
October 28, 2016: Thrombosis Research
https://www.readbyqxmd.com/read/28109187/antimicrobial-and-antioxidant-activities-of-saccharomyces-cerevisiae-ifst062013-a-potential-probiotic
#7
Md Fakruddin, Md Nur Hossain, Monzur Morshed Ahmed
BACKGROUND: Probiotic yeast has become a field of interest to scientists in recent years. METHODS: Conventional cultural method was employed to isolate and identify yeast and standard methods were used to determine different probiotic attributes, antimicrobial and antioxidant properties. RESULTS: This study reports potential probiotic properties of a strain of S. cerevisiae IFST 062013 isolated from fruit. The isolate is tolerant to a wide range of temperature and pH, high concentration of bile salt and NaCl, gastric juice, intestinal environment, α-amylase, trypsin and lysozyme...
January 21, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28108882/prevalence-of-vitamin-b12-and-folate-deficiency-in-school-children-residing-at-high-altitude-regions-in-india
#8
Aakriti Gupta, Umesh Kapil, Lakshmy Ramakrishnan, Ravindra Mohan Pandey, Chander Prakash Yadav
OBJECTIVE: To assess the prevalence of vitamin B12 and folate deficiencies among children residing at high altitude regions of Himachal Pradesh, India. METHODS: A total of 215 school children in the age group of 6-18 y were included. Biochemical estimation of serum vitamin B12 and folate levels was undertaken using chemiluminescence immunoassay method. The consumption pattern of foods high in dietary vitamin B12 and folate was recorded using Food Frequency Questionnaire...
January 21, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28108628/metabolic-reprogramming-by-folate-restriction-leads-to-a-less-aggressive-cancer-phenotype
#9
Zahra Ashkavand, Ciara O'Flanagan, Mirko Hennig, Xiuxia Du, Stephen D Hursting, Sergey A Krupenko
: Folate coenzymes are involved in biochemical reactions of one-carbon transfer, and deficiency of this vitamin impairs cellular proliferation, migration, and survival in many cell types. Here, the effect of folate restriction on mammary cancer was evaluated using three distinct breast cancer subtypes differing in their aggressiveness and metastatic potential: noninvasive basal-like (E-Wnt), invasive but minimally metastatic claudin-low (M-Wnt), and highly metastatic claudin-low (metM-Wnt(liver)) cell lines, each derived from the same pool of MMTV-Wnt-1 transgenic mouse mammary tumors...
January 20, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28108470/associations-of-maternal-vitamin-b12-concentration-in-pregnancy-with-the-risks-of-preterm-birth-and-low-birth-weight-a-systematic-review-and-meta-analysis-of-individual-participant-data
#10
Tormod Rogne, Myrte J Tielemans, Mary Foong-Fong Chong, Chittaranjan S Yajnik, Ghattu V Krishnaveni, Lucilla Poston, Vincent W V Jaddoe, Eric A P Steegers, Suyog Joshi, Yap-Seng Chong, Keith M Godfrey, Fabian Yap, Raquel Yahyaoui, Tinku Thomas, Gry Hay, Marije Hogeveen, Ahmet Demir, Ponnusamy Saravanan, Eva Skovlund, Marit P Martinussen, Geir W Jacobsen, Oscar H Franco, Michael B Bracken, Kari R Risnes
Vitamin B12 (hereafter referred to as B12) deficiency in pregnancy is prevalent and has been associated with both lower birth weight (birth weight <2,500 g) and preterm birth (length of gestation <37 weeks). Nevertheless, current evidence is contradictory. We performed a systematic review and a meta-analysis of individual participant data to evaluate the associations of maternal serum or plasma B12 concentrations in pregnancy with offspring birth weight and length of gestation. Twenty-two eligible studies were identified (11,993 observations)...
January 20, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28108338/dietary-zinc-promotes-immuno-biochemical-plasticity-and-protects-fish-against-multiple-stresses
#11
Neeraj Kumar, K K Krishnani, Paritosh Kumar, Ashish Kumar Jha, Sanjay Kumar Gupta, N P Singh
The abiotic and biotic stress is an episode that effect on regulatory, neuron, endocrine and immune systems of animals including fish. The stress creates stimulatory and suppressive of immune system resulting in increases the incidence of infection. In view of these points, we have conducted an experiment to mitigate the stress through a nutritional approach through Zinc (Zn) supplementation in Pangasius hypophthalmus (initial weight-3.65 ± 0.75 g). Three isocaloric and isonitrogenous diets with graded levels of zinc 0, 10 and 20 mg/kg were prepared and fed to seven different groups with each in triplicate...
January 17, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28108200/vitamin-d-status-among-the-juvenile-population-a-retrospective-study
#12
REVIEW
Afrozul Haq, Jitka Svobodová, Nighat Y Sofi, Andrea Jindrová, Bohumil Kába, Jaishen Rajah, Fatme Al Anouti, Laila Abdel-Wareth, Sunil J Wimalawansa, Mohammed S Razzaque
Vitamin D deficiency is a clinical problem and recently we have shown that 82.5% of our entire study cohort had inadequate serum 25(OH)D levels. In this study, we analysed serum 25(OH)D levels of juvenile patients admitted to the Burjeel Hospital of VPS Health care in Abu Dhabi, United Arab Emirates (UAE) from October 2012 to September 2014. Out of a total of 7883 juvenile patients considered in this study, almost 58.1% of females and 43.3% of males in the age group of 1-18 years were found to have low serum 25(OH)D levels (<50nmol/L)...
January 17, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28107939/a-sensitive-chemiluminescent-immunoassay-to-detect-chromotrope-fb-chr-fb-in-foods
#13
Kun Xu, Hao Long, Rongge Xing, Yongmei Yin, Sergei A Eremin, Meng Meng, Rimo Xi
Chromotrope FB (Chr FB) is a synthetic azo dye permitted for use in foods and medicines. An acceptable daily intake (ADI) of Chr FB was 0-0.5mg/kg in China. In this study, we synthesized a Chr FB hapten with an amino group to prepare its artificial immunogen. Polyclonal antibodies obtained from New Zealand rabbits were applied to develop an indirect competitive chemiluminescent immunoassay (icCLIA) to detect Chr FB in foods. A horseradish peroxidase (HRP)-luminol-H2O2 system was used to yield CL signal with p-iodophenol as an enhancement reagent...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107923/a-sensitive-and-rapid-uflc-apci-ms-ms-bioanalytical-method-for-quantification-of-endogenous-and-exogenous-vitamin-k1-isomers-in-human-plasma-development-validation-and-first-application-to-a-pharmacokinetic-study
#14
Nagaraj Kumar Nannapaneni, Sunil S Jalalpure, Rajendraprasad Muppavarapu, Sunil Kumar Sirigiri
Due to lack of suitable bioanalytical methods in previous literature, for simultaneous estimation of Vitamin K1 isomers, in compliance with the current regulatory expectation, we aimed to develop a sensitive and rapid method with UFLC-APCI-MS/MS (ultrafast liquid chromatography - tandem mass spectrometry) using human plasma. A simple and cost effective procedure was implemented with the combination of protein precipitation and liquid extraction, to isolate the targets from plasma sample, while achieving an insignificant matrix effects and high recovery (≥88...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107866/potential-of-zimbabwean-commercial-probiotic-products-and-strains-of-lactobacillus-plantarum-as-prophylaxis-and-therapy-against-diarrhoea-caused-by-escherichia-coli-in-children
#15
Walter Chingwaru, Jerneja Vidmar
OBJECTIVE: To evaluate the potential of commercial fermented products sold in the country, and strains of Lactobacillus plantarum (L. plantarum) as prophylaxis and therapy against diarrhoea in children. METHODS: The antimicrobial potential of cultures of lactobacilli enriched from 4 Zimbabwean commercial food/beverage products: Dairibord Lacto sour milk (DLSM), Probrand sour milk (PSM), Kefalos Vuka cheese (KVC) and Chibuku opaque beer (COB); and four strains of L...
January 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28107851/effect-of-vitamin-d-supplementation-on-polycystic-ovary-syndrome-a%C3%A2-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#16
REVIEW
Fang Fang, Ke Ni, Yiting Cai, Jin Shang, Xiaoke Zhang, Chengliang Xiong
OBJECTIVE: To evaluate the effect of vitamin D supplementation on patients with PCOS. METHODS: We performed a literature search in database and identified all of the RCTs published before December 2015 that compared the effect of vitamin D supplementation with placebo or metformin in PCOS patients. MAIN RESULTS: Nine out of 463 identified studies were included, involving 502 women presenting with PCOS. Vitamin D supplementation had significant effect on the improvement of follicular development with a higher number of dominant follicles (OR, 2...
February 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/28107795/adherence-to-therapies-in-cystic-fibrosis-a-targeted-literature-review
#17
Siva Narayanan, Jochen G Mainz, Smeet Gala, Harold Tabori, Daniel Grossoehme
Cystic fibrosis (CF) is a life-shortening condition with no cure. Available therapies relieving the symptoms of CF are complex and time-consuming. A comprehensive review assessing adherence to different CF therapies, association of adherence with outcomes, and factors influencing adherence could inform optimal patient management strategies. Areas covered: A targeted literature review of studies published from 2010-2016 assessed adherence to CF therapies. Nineteen studies qualified for inclusion. Adherence to CF therapies was sub-optimal, and varied by treatment, mode of treatment administration, age, season, time and method of adherence measurement...
January 20, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28107722/microalgae-biorefinery-high-value-products-perspectives
#18
Kit Wayne Chew, Jing Ying Yap, Pau Loke Show, Ng Hui Suan, Joon Ching Juan, Tau Chuan Ling, Duu-Jong Lee, Jo-Shu Chang
Microalgae have received much interest as a biofuel feedstock in response to the uprising energy crisis, climate change and depletion of natural sources. Development of microalgal biofuels from microalgae does not satisfy the economic feasibility of overwhelming capital investments and operations. Hence, high-value co-products have been produced through the extraction of a fraction of algae to improve the economics of a microalgae biorefinery. Examples of these high-value products are pigments, proteins, lipids, carbohydrates, vitamins and anti-oxidants, with applications in cosmetics, nutritional and pharmaceuticals industries...
January 10, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28107553/protective-effect-of-n-n-dimethylthiourea-against-stress-induced-gastric-mucosal-lesions-in-rats
#19
Yoshiji Ohta, Koji Yashiro, Takashi Kobayashi, Kazuo Inui, Junji Yoshino
In the present study, we examined the protective effect of N,N'-dimethylthiourea (DMTU), a scavenger of hydroxyl radical (•OH), against water-immersion restraint stress (WIRS)-induced gastric mucosal lesions in rats. When male Wistar rats fasted for 24 h were exposed to WIRS for 3 h, gastric mucosal lesions occurred with increases in the levels of gastric mucosal myeloperoxidase, an index of tissue neutrophil infiltration, pro-inflammatory cytokines (tumor necrosis factor alpha and interleukin 1beta), lipid peroxide, and NOx (nitrite/nitrate), an index of nitric oxide synthesis, and decreases in the levels of gastric mucosal non-protein SH and vitamin C and gastric adherent mucus...
January 20, 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/28107527/effects-of-the-administration-of-25-oh-vitamin-d3-in-an-experimental-model-of-chronic-kidney-disease-in-animals-null-for-1-alpha-hydroxylase
#20
Noelia Torremadé, Milica Bozic, David Goltzman, Elvira Fernandez, José M Valdivielso
The final step in vitamin D activation is catalyzed by 1-alpha-hydroxylase (CYP27B1). Chronic kidney disease (CKD) is characterized by low levels of both 25(OH)D3 and 1,25(OH)2D3 provoking secondary hyperparathyroidism (2HPT). Therefore, treatments with active or native vitamin D compounds are common in CKD to restore 25(OH)D3 levels and also to decrease PTH. This study evaluates the dose of 25(OH)D3 that restores parathyroid hormone (PTH) and calcium levels in a model of CKD in CYP27B1-/- mice. Furthermore, we compare the safety and efficacy of the same dose in CYP27B1+/+ animals...
2017: PloS One
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