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Alzheimers and exercise

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https://www.readbyqxmd.com/read/28222531/physical-exercise-with-music-maintains-activities-of-daily-living-in-patients-with-dementia-mihama-kiho-project-part-21
#1
Masayuki Satoh, Jun-Ichi Ogawa, Tomoko Tokita, Noriko Nakaguchi, Koji Nakao, Hirotaka Kida, Hidekazu Tomimoto
BACKGROUND: Recent studies suggest that combined non-pharmacological interventions are more beneficial than single interventions for primary and secondary prevention of dementia. We previously reported enhanced effects of physical exercise with music (ExM) on cognitive function in normal elderly people compared to exercise alone. OBJECTIVE: To identify if ExM improves cognitive function and activities of daily living (ADLs) in dementia patients over cognitive stimulation (CS)...
February 7, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28222505/cognitive-training-interventions-for%C3%A2-patients-with-alzheimer-s-disease-a%C3%A2-systematic-review
#2
Eeva-Liisa Kallio, Hanna Öhman, Hannu Kautiainen, Marja Hietanen, Kaisu Pitkälä
BACKGROUND: Cognitive training (CT) refers to guided cognitive exercises designed to improve specific cognitive functions, as well as enhance performance in untrained cognitive tasks. Positive effects of CT on cognitive functions in healthy elderly people and persons with mild cognitive impairment have been reported, but data regarding the effects of CT in patients with dementia is unclear. OBJECTIVE: We systematically reviewed the current evidence from randomized controlled trials (RCTs) to find out if CT improves or stabilizes cognition and/or everyday functioning in patients with mild and moderate Alzheimer's disease...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28187125/aerobic-exercise-for-alzheimer-s-disease-a-randomized-controlled-pilot-trial
#3
Jill K Morris, Eric D Vidoni, David K Johnson, Angela Van Sciver, Jonathan D Mahnken, Robyn A Honea, Heather M Wilkins, William M Brooks, Sandra A Billinger, Russell H Swerdlow, Jeffrey M Burns
BACKGROUND: There is increasing interest in the role of physical exercise as a therapeutic strategy for individuals with Alzheimer's disease (AD). We assessed the effect of 26 weeks (6 months) of a supervised aerobic exercise program on memory, executive function, functional ability and depression in early AD. METHODS AND FINDINGS: This study was a 26-week randomized controlled trial comparing the effects of 150 minutes per week of aerobic exercise vs. non-aerobic stretching and toning control intervention in individuals with early AD...
2017: PloS One
https://www.readbyqxmd.com/read/28157102/a-3-month-aerobic-training-program-improves-brain-energy-metabolism-in%C3%A2-mild%C3%A2-alzheimer-s-disease-preliminary-results-from-a-neuroimaging-study
#4
Christian-Alexandre Castellano, Nancy Paquet, Isabelle J Dionne, Hélène Imbeault, Francis Langlois, Etienne Croteau, Sébastien Tremblay, Mélanie Fortier, J Jacques Matte, Guy Lacombe, Tamás Fülöp, Christian Bocti, Stephen C Cunnane
BACKGROUND: Aerobic training has some benefits for delaying the onset or progression of Alzheimer's disease (AD). Little is known about the implication of the brain's two main fuels, glucose and ketones (acetoacetate), associated with thesebenefits. OBJECTIVE: To determine whether aerobic exercise training modifies brain energy metabolism in mild AD. METHODS: In this uncontrolled study, ten patients with mild AD participated in a 3-month, individualized, moderate-intensity aerobic training on a treadmill (Walking)...
February 1, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28157094/treadmill-exercise-exerts-neuroprotection-and-regulates-microglial-polarization-and-oxidative-stress-in-a-streptozotocin-induced-rat-model-of-sporadic-alzheimer-s-disease
#5
Yujiao Lu, Yan Dong, Donovan Tucker, Ruimin Wang, Mohammad Ejaz Ahmed, Darrell Brann, Quanguang Zhang
Recent work has suggested that exercise may be beneficial in preventing or ameliorating symptoms of several neurological disorders, although the mechanism is not entirely understood. The current study was designed to examine the potential beneficial effect of treadmill exercise upon cognitive function in a streptozotocin (STZ)-induced rat model of Alzheimer's disease (AD). Animals underwent treadmill exercise (30 min/day, 5 days/week) for 4 weeks after bilateral STZ intracerebroventricular injection (2.4 mg/kg)...
February 1, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28149509/music-therapy-is-a-potential-intervention-for-cognition-of-alzheimer-s-disease-a-mini-review
#6
REVIEW
Rong Fang, Shengxuan Ye, Jiangtao Huangfu, David P Calimag
Alzheimer's Disease (AD) is a global health issue given the increasing prevalence rate and the limitations of drug effects. As a consequent, non-pharmacological interventions are of importance. Music therapy (MT) is a non-pharmacological way with a long history of use and a fine usability for dementia patients. In this review, we will summarize different techniques, diverse clinical trials, and the mechanisms of MT as it is helpful to the cognition in AD, providing reference for future research. Many articles have demonstrated that MT can reduce cognitive decline especially in autobiographical and episodic memories, psychomotor speed, executive function domains, and global cognition...
2017: Translational Neurodegeneration
https://www.readbyqxmd.com/read/28119873/treadmill-exercise-ameliorates-symptoms-of-alzheimer-disease-through-suppressing-microglial-activation-induced-apoptosis-in-rats
#7
Seung-Soo Baek, Sang-Hoon Kim
Alzheimer disease (AD) is a most common form of dementia and eventually causes impairments of learning ability and memory function. In the present study, we investigated the effects of treadmill exercise on the symptoms of AD focusing on the microglial activation-induced apoptosis. AD was made by bilateral intracerebroventricular injection of streptozotocin. The rats in the exercise groups were made to run on a treadmill once a day for 30 min during 4 weeks. The distance and latency in the Morris water maze task and the latency in the step-down avoidance task were increased in the AD rats, in contrast, treadmill exercise shortened these parameters...
December 2016: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/28112351/nonpharmacological-strategies-for-patients-with-early-stage-dementia-or-mild-cognitive-impairment-a-10-year-update
#8
Joel G Anderson, Ruth Palan Lopez, Karen M Rose, Janet K Specht
As the incidence and prevalence of early-stage Alzheimer's disease and mild cognitive impairment increases worldwide, gerontological researchers continue to examine the efficacy and effectiveness of strategies to help patients and caregivers live with the disease. Although pharmacological treatments remain the focus of much of the research, nonpharmacological strategies and approaches to care continue to gain ground as effective means of improving the health-related quality of life for this patient population...
January 1, 2017: Research in Gerontological Nursing
https://www.readbyqxmd.com/read/28078981/resilience-to-alzheimer-s-disease-the-role-of-physical-activity
#9
Anna Pedrinolla, Federico Schena, Massimo Venturelli
BACKGROUND: Although Alzheimer's disease (AD) is a neurodegenerative pathology characterized by accumulation of β-amyloid plaques and neurofibrillary tangles at cerebral level, recent studies highlighted that AD might be the result of many altered physiological processes occurring at whole-organism level. The ability to adapt to stressors by "bending" but not "breaking" can be considered as "resilience". Individuals incline to withstand such pathophysiological challenges, can be considered more resilient than those that do not...
11, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28074678/prevention-of-alzheimer-s-disease-cerebrovascular-disease-and-dementia-in-women-the-case-for-menopause-hormone-therapy
#10
Dennis A Davey
Alzheimer's disease, cerebrovascular disease and aging-related cognitive impairment and dementia (ARCID) increase in prevalence in women with advancing age. The development of Alzheimer's disease, cerebrovascular disease and ARCID may be postponed or prevented by protective measures including the active treatment of vascular risk factors and continuing exercise and healthy lifestyle from early- and mid-life onward. Bilateral oophorectomy before the natural menopause is associated with an increased incidence of ARCID and the increased risk is significantly reduced by estrogen therapy...
February 2017: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/28067736/alzheimer-s-disease-and-exercise-a-literature-review
#11
Shane P Cass
Alzheimer's disease (AD) is a progressive neurodegenerative disease that impairs memory and cognitive judgment. It is the leading cause of dementia in late adult life and is associated with a significant social burden and increased morbidity and mortality in the elderly. Because of mixed effectiveness of medications, exercise has been considered as a treatment for pre-clinical AD, late stage AD, and as a prevention strategy. Exercise appears to improve brain blood flow, increase hippocampal volume, and improve neurogenesis...
January 2017: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/28064170/cardiorespiratory-fitness-and-brain-volumes-in-men-and-women-in-the-finger-study
#12
Heikki Pentikäinen, Tiia Ngandu, Yawu Liu, Kai Savonen, Pirjo Komulainen, Merja Hallikainen, Miia Kivipelto, Rainer Rauramaa, Hilkka Soininen
BACKGROUND: high cardiorespiratory fitness (CRF) is associated with larger brain volumes but data on sex differences in the association of CRF with brain volumes are scarce. We investigated whether the association of CRF with total grey matter (GM) and white matter volumes as well as medial temporal lobe and striatum volumes is different between men and women at increased risk for Alzheimer's disease (AD). METHODS: we used baseline data from The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) in which the inclusion criteria were set to select individuals with cognitive performance at the mean level or slightly lower than expected for age according to Finnish population norms...
January 6, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28058207/memory-loss-five-new-things
#13
Ferenc Deak, Nidhi Kapoor, Calin Prodan, Linda A Hershey
PURPOSE OF REVIEW: Memory loss can be due to a wide variety of causes. We provide new information about the biology of common genetic and acquired causes of memory loss in older adults. RECENT FINDINGS: New data are available about the genetics of Alzheimer disease (AD), dementia with Lewy bodies (DLB), and frontotemporal dementia. Amyloid PET, FDG-PET, and MRI have improved our understanding of how mild cognitive impairment evolves to AD. Several studies have shown links between concussion and chronic traumatic encephalopathy...
December 2016: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/28057424/sundown-syndrome-sleep-quality-and-walking-among-community-dwelling-people-with-alzheimer-disease
#14
Yen-Hua Shih, Ming-Chyi Pai, Ying-Che Huang, Jing-Jy Wang
PURPOSES: Sundown syndrome and sleep disturbances cause people with Alzheimer disease (PAD) and caregivers suffering. Studies have indicated that physical exercise could have a positive impact on sundown syndrome, yet no research has ever explored the relationship between walking and sundown syndrome. The aims of this study were to examine the relationship between sundown syndrome and sleep quality, and determine whether the severity of dementia, sleep quality, and weekly duration of walking influenced sundown syndrome, and to assess differences in sundown syndrome and sleep quality in relation to the accompanying walker and weekly duration of walking among people with Alzheimer disease living in the community...
January 2, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28039287/vascular-biomarkers-to-predict-response-to-exercise-in-alzheimer-s-disease-the-study-protocol
#15
Danni Li, Robin Thomas, Michael Y Tsai, Ling Li, David M Vock, Susan Greimel, Fang Yu
INTRODUCTION: Exercise interventions are a promising treatment for improving cognition in persons with Alzheimer's disease. This is similar to Alzheimer's disease pharmacotherapies in which only 18-48% of treated patients demonstrate improvement in cognition. Aerobic exercise interventions positively affect brain structure and function through biologically sound pathways. However, an under-studied mechanism of aerobic exercise's effects is n-3 fatty acids in plasma. The objective of this pilot study is to inform a future large-scale study to develop n-3 fatty acids-based prediction of cognitive responses to aerobic exercise treatment in Alzheimer's disease...
December 30, 2016: BMJ Open
https://www.readbyqxmd.com/read/27999771/validation-of-evidence-based-fall-prevention-programs-for-adults-with-intellectual-and-or-developmental-disorders-a-modified-otago-exercise-program
#16
Mindy Renfro, Donna B Bainbridge, Matthew Lee Smith
INTRODUCTION: Evidence-based fall prevention (EBFP) programs significantly decrease fall risk, falls, and fall-related injuries in community-dwelling older adults. To date, EBFP programs are only validated for use among people with normal cognition and, therefore, are not evidence-based for adults with intellectual and/or developmental disorders (IDD) such as Alzheimer's disease and related dementias, cerebral vascular accident, or traumatic brain injury. BACKGROUND: Adults with IDD experience not only a higher rate of falls than their community-dwelling, cognitively intact peers but also higher rates and earlier onset of chronic diseases, also known to increase fall risk...
2016: Frontiers in Public Health
https://www.readbyqxmd.com/read/27978791/exercise-prevents-cognitive-function-decline-and-demyelination-in-the-white-matter-of-app-ps1-transgenic-ad-mice
#17
Lei Zhang, Feng-Lei Chao, Yan-Min Luo, Qian Xiao, Lin Jiang, Chun-Ni Zhou, Yi Zhang, Fu-Lin Lv, Qi He, Jing Ma, Yong Tang
It is unclear whether exercise delays the cognitive function decline and structural changes that occur in Alzheimer's disease (AD). In this study, 6-month-old male APP/PS1 double transgenic mice were exercised by running for 20 min/day for four months, and then the effects of exercise on cognitive function and white matter in these AD mice were investigated. We found that the mean escape latency of the exercised group was significantly decreased compared with that of the sedentary group and that the percentage of time spent in the target quadrant and the target zone frequency were significantly increased...
December 13, 2016: Current Alzheimer Research
https://www.readbyqxmd.com/read/27928511/latino-hispanic-alzheimer-s-caregivers-experiencing-dementia-related-dressing-issues-corroboration-of-the-preservation-of-self-model-and-reactions-to-a-smart-dresser-computer-based-dressing-aid
#18
Diane Feeney Mahoney, David W Coon, Cecil Lozano
OBJECTIVE: To gain an understanding of Latino/Hispanic caregivers' dementia-related dressing issues, their impressions of using a "smart" context-aware dresser to coach dressing, and recommendations to improve its acceptability. METHOD: The same Latina moderator conducted all the caregiver focus groups. She followed a semi-structured interview guide that was previously used with White and African American family caregivers who experienced Alzheimer's disease related dressing challenges...
November 2016: Digit Health
https://www.readbyqxmd.com/read/27911299/chronotropic-response-and-cognitive-function-in-a-cohort-at-risk-for%C3%A2-alzheimer-s-disease
#19
Lena L Law, Stephanie A Schultz, Elizabeth A Boots, Jean A Einerson, Ryan J Dougherty, Jennifer M Oh, Claudia E Korcarz, Dorothy F Edwards, Rebecca L Koscik, N Maritza Dowling, Catherine L Gallagher, Barbara B Bendlin, Cynthia M Carlsson, Sanjay Asthana, Bruce P Hermann, Mark A Sager, Sterling C Johnson, Dane B Cook, James H Stein, Ozioma C Okonkwo
The objective of this study was to examine the association of chronotropic response (CR) and heart rate (HR) recovery- two indices of cardiovascular function within the context of a graded exercise test- with cognitive performance in a cognitively healthy, late-middle-aged cohort at risk for Alzheimer's disease (AD). Ninety participants (age = 63.52±5.86 years; 65.6% female) from the Wisconsin Registry for Alzheimer's Prevention participated in this study. They underwent graded exercise testing and a comprehensive neuropsychological assessment that assessed the following four cognitive domains: Immediate Memory, Verbal & Learning Memory, Working Memory, and Speed & Flexibility...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27909646/the-neural-mechanisms-of-meditative-practices-novel-approaches-for-healthy-aging
#20
REVIEW
Bianca P Acevedo, Sarah Pospos, Helen Lavretsky
OBJECTIVES: Meditation has been shown to have physical, cognitive, and psychological health benefits that can be used to promote healthy aging. However, the common and specific mechanisms of response remain elusive due to the diverse nature of mind-body practices. METHODS: In this review, we aim to compare the neural circuits implicated in focused-attention meditative practices that focus on present-moment awareness to those involved in active-type meditative practices (e...
2016: Current Behavioral Neuroscience Reports
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