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Alzheimers and exercise

Renata Valle Pedroso, José Maria Cancela, Carlos Ayán, Angelica Miki Stein, Gilson Fuzaro, José Luiz Riani Costa, Francisco J Fraga, Ruth Ferreira Santos-Galduróz
BACKGROUND: Evidence regarding the benefits of physical activity on the mental processing information of patients with Alzheimer's disease assessed objectively is scarce and can be observed through event-related potentials, such as the P300. The aim of the study was to identify the effects of physical exercises on mental processing information in the elderly with Alzheimer's disease through neurophysiological measures (P300 amplitude and latency) and reaction time. METHODS: A total of 31 patients with Alzheimer's disease participated in this study: 14 in functional exercise (FE) group and 17 in social gathering (SG) group who carried out three 1-hour sessions per week of FE and SG activities, respectively, for a 12-week period...
March 15, 2018: Journal of Physical Activity & Health
Chia-Liang Tsai, Jozef Ukropec, Barbara Ukropcová, Ming-Chyi Pai
Although exercise is an effective way to decrease the risk of developing Alzheimer's disease, the biological basis for such benefits from the different exercise modes remains elusive. The present study thus aimed (i) to investigate the effects of acute aerobic or resistance exercise on neurocognitive performances and molecular markers when performing a cognitive task involving executive functioning in older adults with amnestic mild cognitive impairment (aMCI), and (ii) to explore relationships of acute exercise-induced neurocognitive changes with changes in circulating levels of neuroprotective growth factors (e...
2018: NeuroImage: Clinical
Jesús Cespón, Carlo Miniussi, Maria Concetta Pellicciari
A growing body of evidence suggests that healthy elderly individuals and patients with Alzheimer's disease retain an important potential for neuroplasticity. This review summarizes studies investigating the modulation of neural activity and structural brain integrity in response to interventions involving cognitive training, physical exercise and non-invasive brain stimulation in healthy elderly and cognitively impaired subjects (including patients with mild cognitive impairment (MCI) and Alzheimer's disease)...
March 6, 2018: Ageing Research Reviews
Hiroaki Kazui
Previous systematic reviews of non-pharmacological interventions for clinical symptoms in dementia patients have confirmed the effectiveness of cognitive stimulation therapy (CST) for cognitive impairment, exercise therapy for activities of daily living, and music therapy and behavior management techniques for behavioral and psychological symptoms of dementia (BPSD). A Japanese version of CST has been developed and is available, but standardized exercise therapy and music therapy have not been developed. It is also important for informal and formal caregivers to learn behavior management techniques...
March 2018: Brain and Nerve, Shinkei Kenkyū No Shinpo
Lauren T Ptomey, Amanda N Szabo, Erik A Willis, Anna M Gorczyca, J Leon Greene, Jessica C Danon, Joseph E Donnelly
BACKGROUND: Between 250,000 and 400,000 individuals in the United States are diagnosed with Down syndrome (DS). Nearly all adults with DS will develop Alzheimer's disease pathology starting in their thirties. Recent studies suggest that increased physical activity (PA) may be important for maintaining components of cognition, including memory. OBJECTIVE: The purpose of this study was to evaluate changes in cognitive function after completion of a 12-week exercise intervention in adults with DS...
February 26, 2018: Disability and Health Journal
Paul D Loprinzi, Emily Frith, Pamela Ponce
Alzheimer's disease (AD) is a debilitating disease influencing a multitude of outcomes, including memory function. Recent work suggests that memory may be influenced by exercise ("memorcise"), even among those with AD. The present narrative review details 1) the underlying mechanisms of AD; 2) whether exercise has a protective effect in preventing AD; 3) the mechanisms through which exercise may help to prevent AD; 4) the mechanisms through which exercise may help attenuate the progression of AD severity among those with existing AD; 5) the effects and mechanisms through which exercise is associated with memory among those with existing AD; and 6) exercise recommendations for those with existing AD...
February 26, 2018: Physician and Sportsmedicine
Jesse Russell-Williams, Wafa Jaroudi, Tania Perich, Siobhan Hoscheidt, Mohamad El Haj, Ahmed A Moustafa
This study investigates the relationship between mindfulness, meditation, cognition and stress in people with Alzheimer's disease (AD), dementia, mild cognitive impairment and subjective cognitive decline. Accordingly, we explore how the use of meditation as a behavioural intervention can reduce stress and enhance cognition, which in turn ameliorates some dementia symptoms. A narrative review of the literature was conducted with any studies using meditation as an intervention for dementia or dementia-related memory conditions meeting inclusion criteria...
February 21, 2018: Reviews in the Neurosciences
Mariza G Prado Lima, Helen L Schimidt, Alexandre Garcia, Letícia R Daré, Felipe P Carpes, Ivan Izquierdo, Pâmela B Mello-Carpes
Recently, nongenetic animal models to study the onset and development of Alzheimer's disease (AD) have appeared, such as the intrahippocampal infusion of peptides present in Alzheimer amyloid plaques [i.e., amyloid-β (Aβ)]. Nonpharmacological approaches to AD treatment also have been advanced recently, which involve combinations of behavioral interventions whose specific effects are often difficult to determine. Here we isolate the neuroprotective effects of three of these interventions-environmental enrichment (EE), anaerobic physical exercise (AnPE), and social enrichment (SE)-on Aβ-induced oxidative stress and on impairments in learning and memory induced by Aβ...
February 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
Kathryn Mullan, Chris R Cardwell, Bernadette McGuinness, Jayne V Woodside, Gareth J McKay
Serum antioxidants may afford neuroprotection against Alzheimer's disease (AD) via correction of the pro-oxidative imbalance but findings reported have been inconsistent. We compared the pooled mean difference in serum levels of ten dietary antioxidants between patients with AD and cognitively intact controls from 52 studies in meta-analyses using random-effects models. Patients with AD had significantly lower plasma levels of α-carotene, β-carotene, lycopene, lutein, vitamin A, C, and E, and uric acid. No significant difference was observed for plasma levels of β-cryptoxanthin and zeaxanthin...
2018: Journal of Alzheimer's Disease: JAD
Anna Pedrinolla, Massimo Venturelli, Cristina Fonte, Daniele Munari, Maria Vittoria Benetti, Doriana Rudi, Stefano Tamburin, Ettore Muti, Luisa Zanolla, Nicola Smania, Federico Schena
BACKGROUND: Although current literature has shown that patients with Alzheimer's disease (AD) have worse locomotion compared with healthy counterparts, no studies have focused on the efficacy of exercise training in improving gait abnormalities including biomechanics and metabolic aspects, in this population. OBJECTIVE: To verify the effectiveness of exercise training (ET) on gait parameters (i.e., speed, step and stride length, single and double support, and energy cost of walking (Cw)) in patients with AD with respect to a standard cognitive treatment (CT)...
2018: Journal of Alzheimer's Disease: JAD
Gregory A Panza, Beth A Taylor, Hayley V MacDonald, Blair T Johnson, Amanda L Zaleski, Jill Livingston, Paul D Thompson, Linda S Pescatello
OBJECTIVES: To examine the effects of exercise training on cognitive function in individuals at risk of or diagnosed with Alzheimer's disease (AD). DESIGN: Meta-analysis. SETTING: PubMed, Scopus,, and ProQuest were searched from inception until August 1, 2017. PARTICIPANTS: Nineteen studies with 23 interventions including 1,145 subjects with a mean age of 77.0 ± 7.5 were included. Most subjects were at risk of AD because they had mild cognitive impairment (64%) or a parent diagnosed with AD (1%), and 35% presented with AD...
January 24, 2018: Journal of the American Geriatrics Society
Feng-Lei Chao, Lei Zhang, Yi Zhang, Chun-Ni Zhou, Lin Jiang, Qian Xiao, Yan-Min Luo, Fu-Lin Lv, Qi He, Yong Tang
Neurogenesis might influence oligodendrogenesis and selectively instruct myelination in the mammalian brain. Running exercise could induce neurogenesis and protect the myelin sheaths in the dentate gyrus of AD mice. It is unclearwhether running exercise could protect the myelin sheaths in the absence of neurogenesis in the hippocampus of AD mice. Six-month-old male APP/PS1 transgenic mice were randomly assigned to a control group (Tg control) or a running group (Tg runner), and age-matched non-transgenic littermates were used as a wild-type group (WT control)...
January 6, 2018: Brain Research
Mohammad Azimi, Reza Gharakhanlou, Nasser Naghdi, Davar Khodadadi, Soomaayeh Heysieattalab
Alzheimer's disease (AD) is a neurodegenerative disorder associated with loss of memory and cognitive abilities. Previous evidence suggested that exercise ameliorates learning and memory deficits by increasing brain derived neurotrophic factor (BDNF) and activating downstream pathways in AD animal models. However, upstream pathways related to increase BDNF induced by exercise in AD animal models are not well known. We investigated the effects of moderate treadmill exercise on Aβ-induced learning and memory impairment as well as the upstream pathway responsible for increasing hippocampal BDNF in an animal model of AD...
January 5, 2018: Peptides
Bo Ae Lee, Su Jin Kim, Don Kyoung Choi, Ohseong Kwon, Hae Ri Na, Sung Tae Cho
PURPOSE: Pelvic floor muscle exercise (PFME) is a therapeutic option for urinary incontinence (UI). However, studies of the efficacy of PFME on UI in patients with cognitive impairment (CI) are lacking. Therefore, we evaluated the effect of PFME on UI in elderly women with mild CI. METHODS: A total of 150 women with mild CI or Alzheimer disease and UI were screened using the International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF). Cognitive function and behavioral symptoms were evaluated by the Mini-Mental State Examination and Barthel's Activities of Daily Living...
December 2017: International Neurourology Journal
Eric D Vidoni, Jaime Perales, Mohammed Alshehri, Abdul-Mannaan Giles, Catherine F Siengsukon, Jeffrey M Burns
BACKGROUND AND PURPOSE: Individuals with Alzheimer disease (AD) experience progressive loss of independence-performing activities of daily living. Identifying interventions to support independence and reduce the economic and psychosocial burden of caregiving for individuals with AD is imperative. The purpose of this analysis was to examine functional disability and caregiver time in individuals with early-stage AD. METHODS: This was a secondary analysis of a randomized controlled trial of 26 weeks of aerobic exercise (AEx) versus stretching and toning (ST)...
December 28, 2017: Journal of Geriatric Physical Therapy
Masato Iwabu, Toshimasa Yamauchi, Miki Okada-Iwabu, Takashi Kadowaki
Modern society is characterized by an explosion of lifestyle-related diseases that have, as their basis, obesity due to lack of exercise, which include the metabolic syndrome, diabetes, cardiovascular disease, cancer, and Alzheimer's disease. While exercise is known to be a definitive preventive or therapeutic measure against these diseases, it is clear that contemporary lifestyles tend to make exercise rather difficult to continue. Thus, there are mounting expectations worldwide for exercise-mimicking drugs that activate exercise-mediated signaling pathways...
2018: Clinical Calcium
Jing Zhang, Yunliang Guo, Yongxiang Wang, Lin Song, Rui Zhang, Yifeng Du
Alzheimer's disease (AD) is a devastating disease characterized with progressive neurodegenerative disorders in the elderly. Epidemiological and clinical studies reported that lifestyle factors could halt the progression of AD, especially physical exercise. In the present work, we investigated the effects of long-term treadmill exercise on the pathological cascades of AD in APP/PS1 mice. After exercise for 5 months, Aβ deposition was significantly ameliorated in terms of Aβ area fraction, plaque number and size...
December 12, 2017: Neuroscience Letters
Sergio Machado, Alberto Souza de Sá Filho, Matheus Wilbert, Gabriela Barbieri, Victor Almeida, Alexandre Gurgel, Charles V Rosa, Victor Lins, Alexandre Paixão, Kamila Santana, Gabriel Ramos, Geraldo Maranhão Neto, Flá Paes, Nuno Rocha, Eric Murillo-Rodriguez
Introduction: Mental health decline is one of the main responsible factors for augments in health care costs, and diagnosis of Alzheimer's disease (AD). Some studies stated physical exercise is useful for reduction in cognitive decline and AD. Moreover, a recent review argued that evidence are scarce due to few studies published and lack of configuration information of exercise protocol, such as intensity and duration of exercise, number of sessions and other relevant data, to allow appropriate assessment...
2017: Clinical Practice and Epidemiology in Mental Health: CP & EMH
Chongyun Wu, Luodan Yang, Donovan Tucker, Yan Dong, Ling Zhu, Rui Duan, Timon Cheng-Yi Liu, Quanguang Zhang
PURPOSE: This study aimed to examine the effects of swimming exercise pretreatment on a streptozotocin (STZ)-induced sporadic Alzheimer's disease rat model and provide an initial understanding of related molecular mechanisms. METHODS: Male 2.5-month-old Sprague-Dawley rats were divided into the following 4 groups: a) control, b) swim + vehicle, c) STZ without swim, and d) swim + STZ. The Barnes Maze task and Novel Object Recognition test were used to measure hippocampus-dependent spatial learning and working memory, respectively...
December 11, 2017: Medicine and Science in Sports and Exercise
Stephanie Ziegler-Waldkirch, Paolo d'Errico, Jonas-Frederic Sauer, Daniel Erny, Shakuntala Savanthrapadian, Desirée Loreth, Natalie Katzmarski, Thomas Blank, Marlene Bartos, Marco Prinz, Melanie Meyer-Luehmann
Alzheimer's disease (AD) is characterized by severe neuronal loss as well as the accumulation of amyloid-β (Aβ), which ultimately leads to plaque formation. Although there is now a general agreement that the aggregation of Aβ can be initiated by prion-like seeding, the impact and functional consequences of induced Aβ deposits (Aβ seeding) on neurons still remain open questions. Here, we find that Aβ seeding, representing early stages of plaque formation, leads to a dramatic decrease in proliferation and neurogenesis in two APP transgenic mouse models...
January 17, 2018: EMBO Journal
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