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Alzheimers and exercise

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https://www.readbyqxmd.com/read/29317290/running-exercise-protects-against-myelin-breakdown-in-the-absence-of-neurogenesis-in-the-hippocampus-of-ad-mice
#1
Feng-Lei Chao, Lei Zhang, Yi Zhang, Chun-Ni Zhou, Lin Jiang, Qian Xiao, Yan-Min Luo, Fu-Lin Lv, Qi He, Yong Tang
Neurogenesis might influence oligodendrogenesis and selectively instruct myelination in the mammalian brain. Running exercise could induce neurogenesis and protect the myelin sheaths in the dentate gyrus of AD mice. It is unclearwhether running exercise could protect the myelin sheaths in the absence of neurogenesis in the hippocampus of AD mice. Six-month-old male APP/PS1 transgenic mice were randomly assigned to a control group (Tg control) or a running group (Tg runner), and age-matched non-transgenic littermates were used as a wild-type group (WT control)...
January 6, 2018: Brain Research
https://www.readbyqxmd.com/read/29309801/moderate-treadmill-exercise-ameliorates-amyloid-%C3%AE-induced-learning-and-memory-impairment-possibly-via-increasing-ampk-activity-and-up-regulation-of-the-pgc-1%C3%AE-fndc5-bdnf-pathway
#2
Mohammad Azimi, Reza Gharakhanlou, Nasser Naghdi, Davar Khodadadi, Soomaayeh Heysieattalab
Alzheimer's disease (AD) is a neurodegenerative disorder associated with loss of memory and cognitive abilities. Previous evidence suggested that exercise ameliorates learning and memory deficits by increasing brain derived neurotrophic factor (BDNF) and activating downstream pathways in AD animal models. However, upstream pathways related to increase BDNF induced by exercise in AD animal models are not well known. We investigated the effects of moderate treadmill exercise on Aβ-induced learning and memory impairment as well as the upstream pathway responsible for increasing hippocampal BDNF in an animal model of AD...
January 5, 2018: Peptides
https://www.readbyqxmd.com/read/29298469/effects-of-pelvic-floor-muscle-exercise-on-urinary-incontinence-in-elderly-women-with-cognitive-impairment
#3
Bo Ae Lee, Su Jin Kim, Don Kyoung Choi, Ohseong Kwon, Hae Ri Na, Sung Tae Cho
PURPOSE: Pelvic floor muscle exercise (PFME) is a therapeutic option for urinary incontinence (UI). However, studies of the efficacy of PFME on UI in patients with cognitive impairment (CI) are lacking. Therefore, we evaluated the effect of PFME on UI in elderly women with mild CI. METHODS: A total of 150 women with mild CI or Alzheimer disease and UI were screened using the International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF). Cognitive function and behavioral symptoms were evaluated by the Mini-Mental State Examination and Barthel's Activities of Daily Living...
December 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/29286983/aerobic-exercise-sustains-performance-of-instrumental-activities-of-daily-living-in-early-stage-alzheimer-disease
#4
Eric D Vidoni, Jaime Perales, Mohammed Alshehri, Abdul-Mannaan Giles, Catherine F Siengsukon, Jeffrey M Burns
BACKGROUND AND PURPOSE: Individuals with Alzheimer disease (AD) experience progressive loss of independence-performing activities of daily living. Identifying interventions to support independence and reduce the economic and psychosocial burden of caregiving for individuals with AD is imperative. The purpose of this analysis was to examine functional disability and caregiver time in individuals with early-stage AD. METHODS: This was a secondary analysis of a randomized controlled trial of 26 weeks of aerobic exercise (AEx) versus stretching and toning (ST)...
December 28, 2017: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/29279429/-developing-exercise-mimicking-drugs-toward-realization-of-preemptive-medicine-for-lifestyle-related-diseases
#5
Masato Iwabu, Toshimasa Yamauchi, Miki Okada-Iwabu, Takashi Kadowaki
Modern society is characterized by an explosion of lifestyle-related diseases that have, as their basis, obesity due to lack of exercise, which include the metabolic syndrome, diabetes, cardiovascular disease, cancer, and Alzheimer's disease. While exercise is known to be a definitive preventive or therapeutic measure against these diseases, it is clear that contemporary lifestyles tend to make exercise rather difficult to continue. Thus, there are mounting expectations worldwide for exercise-mimicking drugs that activate exercise-mediated signaling pathways...
2018: Clinical Calcium
https://www.readbyqxmd.com/read/29246793/long-term-treadmill-exercise-attenuates-a%C3%AE-burdens-and-astrocyte-activation-in-app-ps1-mouse-model-of-alzheimer-s-disease
#6
Jing Zhang, Yunliang Guo, Yongxiang Wang, Lin Song, Rui Zhang, Yifeng Du
Alzheimer's disease (AD) is a devastating disease characterized with progressive neurodegenerative disorders in the elderly. Epidemiological and clinical studies reported that lifestyle factors could halt the progression of AD, especially physical exercise. In the present work, we investigated the effects of long-term treadmill exercise on the pathological cascades of AD in APP/PS1 mice. After exercise for 5 months, Aβ deposition was significantly ameliorated in terms of Aβ area fraction, plaque number and size...
December 12, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29238394/physical-exercise-as-stabilizer-for-alzheimer-s-disease-cognitive-decline-current-status
#7
Sergio Machado, Alberto Souza de Sá Filho, Matheus Wilbert, Gabriela Barbieri, Victor Almeida, Alexandre Gurgel, Charles V Rosa, Victor Lins, Alexandre Paixão, Kamila Santana, Gabriel Ramos, Geraldo Maranhão Neto, Flá Paes, Nuno Rocha, Eric Murillo-Rodriguez
Introduction: Mental health decline is one of the main responsible factors for augments in health care costs, and diagnosis of Alzheimer's disease (AD). Some studies stated physical exercise is useful for reduction in cognitive decline and AD. Moreover, a recent review argued that evidence are scarce due to few studies published and lack of configuration information of exercise protocol, such as intensity and duration of exercise, number of sessions and other relevant data, to allow appropriate assessment...
2017: Clinical Practice and Epidemiology in Mental Health: CP & EMH
https://www.readbyqxmd.com/read/29232315/beneficial-effects-of-exercise-pretreatment-in-a-sporadic-alzheimer-s-rat-model
#8
Chongyun Wu, Luodan Yang, Donovan Tucker, Yan Dong, Ling Zhu, Rui Duan, Timon Cheng-Yi Liu, Quanguang Zhang
PURPOSE: This study aimed to examine the effects of swimming exercise pretreatment on a streptozotocin (STZ)-induced sporadic Alzheimer's disease rat model and provide an initial understanding of related molecular mechanisms. METHODS: Male 2.5-month-old Sprague-Dawley rats were divided into the following 4 groups: a) control, b) swim + vehicle, c) STZ without swim, and d) swim + STZ. The Barnes Maze task and Novel Object Recognition test were used to measure hippocampus-dependent spatial learning and working memory, respectively...
December 11, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29229786/seed-induced-a%C3%AE-deposition-is-modulated-by-microglia-under-environmental-enrichment-in-a-mouse-model-of-alzheimer-s-disease
#9
Stephanie Ziegler-Waldkirch, Paolo D Errico, Jonas-Frederic Sauer, Daniel Erny, Shakuntala Savanthrapadian, Desirée Loreth, Natalie Katzmarski, Thomas Blank, Marlene Bartos, Marco Prinz, Melanie Meyer-Luehmann
Alzheimer's disease (AD) is characterized by severe neuronal loss as well as the accumulation of amyloid-β (Aβ), which ultimately leads to plaque formation. Although there is now a general agreement that the aggregation of Aβ can be initiated by prion-like seeding, the impact and functional consequences of induced Aβ deposits (Aβ seeding) on neurons still remain open questions. Here, we find that Aβ seeding, representing early stages of plaque formation, leads to a dramatic decrease in proliferation and neurogenesis in two APP transgenic mouse models...
December 11, 2017: EMBO Journal
https://www.readbyqxmd.com/read/29226867/an-objective-method-to-accurately-measure-cardiorespiratory-fitness-in-older-adults-who-cannot-satisfy-widely-used-oxygen-consumption-criteria
#10
Ryan J Dougherty, Jacob B Lindheimer, Aaron J Stegner, Stephanie Van Riper, Ozioma C Okonkwo, Dane B Cook
Cardiorespiratory fitness (CRF) is routinely investigated in older adults; however, the most appropriate CRF measure to use for this population has received inadequate attention. This study aimed to 1) evaluate the reliability and validity of the oxygen uptake efficiency slope (OUES) as a sub-maximal measurement of CRF; 2) examine demographic, risk-factor, and exercise testing differences in older adults who satisfied standardized criteria for a peak oxygen consumption (V̇O2peak) test compared to those who did not; and 3) determine the difference between directly measured V̇O2peak values and OUES-predicted V̇O2peak values...
December 6, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29225776/the-sedentary-r-evolution-have-we-lost-our-metabolic-flexibility
#11
Jens Freese, Rainer Johannes Klement, Begoña Ruiz-Núñez, Sebastian Schwarz, Helmut Lötzerich
During the course of evolution, up until the agricultural revolution, environmental fluctuations forced the human species to develop a flexible metabolism in order to adapt its energy needs to various climate, seasonal and vegetation conditions. Metabolic flexibility safeguarded human survival independent of food availability. In modern times, humans switched their primal lifestyle towards a constant availability of energy-dense, yet often nutrient-deficient, foods, persistent psycho-emotional stressors and a lack of exercise...
2017: F1000Research
https://www.readbyqxmd.com/read/29218889/best-practices-and-lessons-learned-from-reuse-of-4-patient-derived-metabolomics-datasets-in-alzheimer-s-disease
#12
Jessica D Tenenbaum, Colette Blach
The importance of open data has been increasingly recognized in recent years. Although the sharing and reuse of clinical data for translational research lags behind best practices in biological science, a number of patient-derived datasets exist and have been published enabling translational research spanning multiple scales from molecular to organ level, and from patients to populations. In seeking to replicate metabolomic biomarker results in Alzheimer's disease our team identified three independent cohorts in which to compare findings...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29210934/a-scoping-review-of-physical-performance-outcome-measures-used-in-exercise-interventions-for-older-adults-with-alzheimer-disease-and-related-dementias
#13
Ellen L McGough, Shih-Yin Lin, Basia Belza, Katie M Becofsky, Dina L Jones, Minhui Liu, Sara Wilcox, Rebecca G Logsdon
BACKGROUND AND PURPOSE: There is growing evidence that exercise interventions can mitigate functional decline and reduce fall risk in older adults with Alzheimer disease and related dementias (ADRD). Although physical performance outcome measures have been successfully used in older adults without cognitive impairment, additional research is needed regarding their use with individuals who have ADRD, and who may have difficulty following instructions regarding performance of these measures...
November 28, 2017: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/29188860/a-keto-mediet-approach-with-coconut-substitution-and-exercise-may-delay-the-onset-of-alzheimer-s-disease-among-middle-aged
#14
B C Perng, M Chen, J C Perng, P Jambazian
BACKGROUND: Coconut oil has been widely used to improve health because there is much information available by word of mouth, in books, and on the internet. However, researchers still continue to search for the best diets to improve the quality of life, especially for people with cognitive decline. OBJECTIVES: The aim of this review is to develop a novel dietary approach, the Keto-Mediet, which may help prevent the onset of Alzheimer's disease. METHODS: Evidence gained through literature review from 1982 to 2015 on gene-by-diet interaction and lipid and glucose metabolism in the brains of Alzheimer's patients is converted into the new Keto-Mediet approach...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29188858/modest-overweight-and-healthy-dietary-habits-reduce-risk-of-dementia-a-nationwide-survey-in-taiwan
#15
C-Y Lee, Y Sun, H-J Lee, T-F Chen, P-N Wang, K-N Lin, L-Y Tang, C-C Lin, M-J Chiu
BACKGROUND: Evidence of the associations of dietary habits and body mass index with dementia is inconsistent and limited in East Asian countries. OBJECTIVE: We aim to explore the associations of dietary habits and body mass index with the odds of dementia. DESIGN: Cross-sectional observational study. SETTING: A nationwide, population-based, door-to-door, in-person survey. PARTICIPANTS: Selected by computerized random sampling from all 19 counties in Taiwan...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29170725/reduction-of-cognitive-decline-in-patients-with-or-at-high-risk-for-diabetes
#16
Gladys E Maestre
Purpose of review: The incidence of Alzheimer's disease and related disorders is expected to triple by 2050. People with type 2 diabetes and prediabetes have a higher risk of cognitive dysfunction, including Alzheimer's disease and vascular dementia. Controversy remains about when and how to prevent and treat cognitive dysfunction in people with or at high risk of diabetes. Recent findings: In our review of ongoing clinical trials, we have found that there has been an increase in the number of studies assessing the efficacy of pharmacological and non-pharmacological approaches to prevent or slow down cognitive impairment among people with or at high risk of diabetes...
September 2017: Current Geriatrics Reports
https://www.readbyqxmd.com/read/29154278/effects-of-physical-exercise-on-alzheimer-s-disease-biomarkers-a-systematic-review-of-intervention-studies
#17
Kristian Steen Frederiksen, Le Gjerum, Gunhild Waldemar, Steen Gregers Hasselbalch
Physical exercise may be an important adjunct to pharmacological treatment of Alzheimer's disease (AD). Animal studies indicate that exercise may be disease modifying through several mechanisms including reduction of AD pathology. We carried out a systematic review of intervention studies of physical exercise with hippocampal volume (on MRI), amyloid-β, total tau, phosphorylated tau in cerebrospinal fluid (CSF), 18F-FDG-PET or amyloid PET as outcome measures in healthy subjects, patients with subjective memory complaints, mild cognitive impairment, or AD...
November 16, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29141548/cognitive-training-in-patients-with-alzheimer-s-disease-findings-of-a-12-month-randomized-controlled-trial
#18
Alessandro Trebbastoni, Letizia Imbriano, Livia Podda, Lidia Rendace, Maria Luisa Sacchetti, Alessandra Campanelli, Fabrizia D Antonio, Carlo de Lena
BACKGROUND: Cognitive training (CT) is a non-pharmacological intervention based on a set of tasks that reflect specific cognitive functions. CT is aimed at improving cognition in patients with cognitive impairment, though no definitive conclusions have yet been drawn on its efficacy in Alzheimer's disease (AD). OBJECTIVE: To assess the effectiveness of a CT program designed to improve cognition in AD patients. METHOD: This is a randomized, controlled, single-blind, longitudinal trial with a no-treatment control condition in mild-to-moderate AD...
November 12, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/29136094/effects-of-multidomain-lifestyle-intervention-omega-3-supplementation-or-their-combination-on-physical-activity-levels-in-older-adults-secondary-analysis-of-the-multidomain-alzheimer-preventive-trial-mapt-randomised-controlled-trial
#19
Philipe de Souto Barreto, Yves Rolland, Matteo Cesari, Charlotte Dupuy, Sandrine Andrieu, Bruno Vellas
Background/objectives: to investigate the effects of a 3-year multidomain lifestyle intervention, omega-3 supplementation or both on physical activity (PA) in older adults with subjective memory complaints. Design/settings/subjects: the Multidomain Alzheimer Preventive Trial was a 3-year randomised controlled trial that enroled 1,680 community-dwelling adults aged 70 years or over, with subjective memory complaints. Participants were randomised to omega-3 supplementation (total daily dose of 800 mg docosahexanoic acid and up to 225 mg eicosapentanoic acid), multidomain intervention (nutritional and exercise counselling and cognitive training), omega-3 plus multidomain intervention or placebo with usual care...
November 10, 2017: Age and Ageing
https://www.readbyqxmd.com/read/29135358/training-area-agencies-on-aging-case-managers-to-improve-physical-function-mood-and-behavior-in-persons-with-dementia-and-caregivers-examples-from-the-rdad-northwest-study
#20
Susan M McCurry, Rebecca G Logsdon, Kenneth C Pike, David M LaFazia, Linda Teri
The Reducing Disability in Alzheimer's Disease (RDAD) program has been shown to be an effective tool for teaching caregivers strategies to improve mood, behavior, and physical function in persons with dementia. This paper describes how RDAD has been translated and implemented for use by Area Agencies on Aging (AAA) case managers across Washington and Oregon. Modifications to the original RDAD program as part of its community translation included decreasing the number of in-person sessions while preserving all educational content; involving caregivers in exercise activities for themselves as well as acting as exercise coaches for care-receivers; and enrolling persons with cognitive impairment due to mixed etiologies...
November 14, 2017: Journal of Gerontological Social Work
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