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Alzheimers and exercise

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https://www.readbyqxmd.com/read/29769247/dementia-and-physical-activity-dapa-trial-of-moderate-to-high-intensity-exercise-training-for-people-with-dementia-randomised-controlled-trial
#1
Sarah E Lamb, Bart Sheehan, Nicky Atherton, Vivien Nichols, Helen Collins, Dipesh Mistry, Sukhdeep Dosanjh, Anne Marie Slowther, Iftekhar Khan, Stavros Petrou, Ranjit Lall
OBJECTIVE: To estimate the effect of a moderate to high intensity aerobic and strength exercise training programme on cognitive impairment and other outcomes in people with mild to moderate dementia. DESIGN: Multicentre, pragmatic, investigator masked, randomised controlled trial. SETTING: National Health Service primary care, community and memory services, dementia research registers, and voluntary sector providers in 15 English regions. PARTICIPANTS: 494 people with dementia: 329 were assigned to an aerobic and strength exercise programme and 165 were assigned to usual care...
May 16, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29768349/comparison-of-multiple-interventions-for-older-adults-with-alzheimer-disease-or-mild-cognitive-impairment-a-prisma-compliant-network-meta-analysis
#2
Jing-Hong Liang, Yong Xu, Lu Lin, Rui-Xia Jia, Hong-Bo Zhang, Lei Hang
BACKGROUND: The increasing prevalence of Alzheimer disease (AD) emphasizes the need for effective treatments. Both pharmacological therapies such as nutrition therapy (NT) and nonpharmacologic therapies including traditional treatment or personalized treatment (e.g., physical exercise, music therapy, computerized cognitive training) have been approved for the treatment of AD or mild cognitive impairment (MCI) in numerous areas. METHODS: The aim of this study was to compare 4 types of interventions, physical exercise (PE), music therapy (MT), computerized cognitive training (CCT), and NT, in older adults with mild to moderate AD or MCI and identify the most effective intervention for their cognitive function...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29758940/self-reported-physical-activity-is-associated-with-tau-burden-measured-by-positron-emission-tomography
#3
Belinda M Brown, Stephanie R Rainey-Smith, Vincent Dore, Jeremiah J Peiffer, Samantha C Burnham, Simon M Laws, Kevin Taddei, David Ames, Colin L Masters, Christopher C Rowe, Ralph N Martins, Victor L Villemagne
Numerous animal studies have reported exercise reduces the accumulation of Alzheimer's disease pathology, including amyloid-β (Aβ) and tau. Furthermore, we previously reported a relationship between higher levels of physical activity (PA) and lower brain Aβ burden in a human population. The recent advent of tau positron emission tomography (PET) tracers enables us to extend our investigations into the evaluation of the relationship between PA and brain tau burden. Utilizing data from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study, we have examined the cross-sectional relationship between habitual PA and PET-quantified tau burden...
May 11, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29736953/cognitive-and-physical-factors-affecting-daily-function-in-alzheimer-s-disease-a-cross-sectional-analysis
#4
Fang Yu, Yan Chen, Michelle A Mathiason, Qiaoqin Wan, Feng V Lin
Understanding the factors affecting activities of daily living (ADL) is important in Alzheimer's disease (AD), because decline in ADL contributes to many poor health outcomes. Existing studies often investigate the factors in isolation without a theoretical framework. The purpose of the present study was to provide preliminary results on how cognition, physical performance, and behavioral and psychological symptoms of dementia mediate the relationship of aerobic fitness and ADL in AD. A cross-sectional analysis was used (n = 28: average age 78 [8] years, education 16 (3) years, Mini-Mental State Examination scores 20 [4])...
May 7, 2018: Nursing & Health Sciences
https://www.readbyqxmd.com/read/29729254/physical-exercise-reserved-amyloid-beta-induced-brain-dysfunctions-by-regulating-hippocampal-neurogenesis-and-inflammatory-response-via-mapk-signaling
#5
Li-Na Sun, Jin-Shun Qi, Rong Gao
Alzheimer's disease (AD) is one of the leading causes of dementia that induced by aggregation of amyloid-beta (Aβ) in brain tissue. With high structural and functional plasticity, hippocampus plays fundamental roles in cognitive regulation. Moreover, impaired hippocampal functions present during early onset of AD. Hence, targeting on improving hippocampal plasticity would be recognized as the effective strategy in AD therapy. Physical exercise is widely encouraged healthy life style. However, whether exercise could reserve the neural dysfunctions in AD model and the possible neurobiological mechanism still need for better understanding...
May 2, 2018: Brain Research
https://www.readbyqxmd.com/read/29726700/acute-exercise-induced-bdnf-trkb-signaling-is-intact-in-the-prefrontal-cortex-of-obese-glucose-intolerant-male-mice
#6
Bradley J Baranowski, Rebecca E K MacPherson
Obesity and glucose intolerance have been directly implicated in the pathology of Alzheimer's disease. It is thought that diet induced obesity causes a reduction in neuronal plasticity through a reduction in the neurotrophin, brain-derived neurotrophic factor (BDNF). Previous work has demonstrated that acute exercise in healthy lean animals increases BDNF-TrkB signaling in the brain. However, if this effect is intact in a state of obesity remains unknown. The purpose of this study is to determine the effects of a single bout of exercise on BDNF-TrkB signaling in the prefrontal cortex and hippocampus from obese glucose intolerant mice...
May 4, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29713339/exercise-intervention-associated-with-cognitive-improvement-in-alzheimer-s-disease
#7
REVIEW
Meng Ying Cui, Yang Lin, Ji Yao Sheng, Xuewen Zhang, Ran Ji Cui
Alzheimer's disease (AD) is a progressive neurodegenerative disease with the syndrome of cognitive and functional decline. Pharmacotherapy has always been in a dominant position for the treatment of AD. However, in most cases, drug therapy is accompanied with clinical delays when older adults have suffered from cognitive decline in episodic memory, working memory, and executive function. On the other hand, accumulating evidence suggests that exercise intervention may ameliorate the progression of cognitive impairment in aging ones while the standard strategy is lacking based on different levels of cognitive decline especially in mild cognitive impairment (MCI) and AD...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29706312/metabolic-syndrome-marks-early-risk-for-cognitive-decline-with-apoe4-gene-variation-a-case-study
#8
Dawson Brown, Kelly J Gibas
A vast amount of research has been done on the APOE4 genetic marker for Alzheimer's disease (AD), but its connection to metabolic processes associated with peripheral insulin resistance and cerebral glucose metabolism is still relatively unknown. The APOE4 allele is the strongest genetic risk factor for developing late-onset Alzheimer's disease, particularly in individuals who have inherited two copies of the gene (Zhao et al., 2017). In this case study, a 38 year old male with metabolic syndrome (MetS), the APOE4 gene, early stage memory problems and a family history of Alzheimer's Disease (AD) was placed on a ketogenic diet combined with high intensity interval training (HIIT) for 10 weeks...
April 20, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29705888/a-physical-exercise-program-using-music-supported-video-based-training-in-older-adults-in-nursing-homes-suffering-from-dementia-a-feasibility-study
#9
Joke Spildooren, Ite Speetjens, Johan Abrahams, Peter Feys, Annick Timmermans
BACKGROUND: Motivation towards an exercise program is higher in a small group setting in comparison to individual therapy. Due to attentional problems, group exercises are difficult for people with Alzheimer disease (AD). This study evaluates the feasibility of a music-supported video-based group exercise program in older adults suffering from AD. METHODS: Five participants with moderate AD were recruited from a nursing home. A progressive physical exercise program using a video-based training with musical accompaniment was performed and digitally recorded to investigate the adherence and performed accuracy of the exercises...
April 28, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29689723/stereological-investigation-of-the-effects-of-treadmill-running-exercise-on-the-hippocampal-neurons-in-middle-aged-app-ps1-transgenic-mice
#10
Fenglei Chao, Lin Jiang, Yi Zhang, Chunni Zhou, Lei Zhang, Jing Tang, Xin Liang, Yingqiang Qi, Yanqing Zhu, Jing Ma, Yong Tang
The risk of cognitive decline during Alzheimer's disease (AD) can be reduced if physical activity is maintained; however, the specific neural events underlying this beneficial effect are still uncertain. To quantitatively investigate the neural events underlying the effect of running exercise on middle-aged AD subjects, 12-month-old male APP/PS1 mice were randomly assigned to a control group or running group, and age-matched non-transgenic littermates were used as a wild-type group. AD running group mice were subjected to a treadmill running protocol (regular and moderate intensity) for four months...
April 16, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29678773/microrna-132-is-associated-with-the-cognition-improvement-following-voluntary-exercise-in-samp8-mice
#11
Jingde Dong, Yi Liu, Zhen Zhan, Xiaoshan Wang
The senescence-accelerated SAMP8 mouse is characterized by progressive cognitive decline and is considered to be a specific model of Alzheimer's disease (AD). A growing body of evidence indicates that physical exercise suppresses age-related cognitive decline. In the current study, we investigated the influence of voluntary wheel running on cognitive function in SAMP8 mice. We found that voluntary physical exercise ameliorated cognition decline and suppressed hippocampal neurodegeneration in SAMP8 mice. MicroRNA-132 (miR-132) is a short non-coding RNA which is enriched in the brain and is implicated in the regulation of neuronal activity and cognitive function...
April 17, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29678606/ketogenic-diet-high-intensity-interval-training-hiit-and-memory-training-in-the-treatment-of-mild-cognitive-impairment-a-case-study
#12
Kaitlyn Dahlgren, Kelly J Gibas
Alzheimer's disease (AD) deaths have increased by 89% since 2000. This alarming trajectory of neurological disease highlights the failure of current best practice. Deteriorating brain fuel supply is the nemesis of intact neurological health. Cerebral hypo-metabolism associated with AD occurs years before onset. Both the ketogenic diet and calorie restriction (fasting) lead to a compensatory rise in ketones to improve energy deficits in the brain derived from cerebral insulin resistance. Two forms of ketone bodies, β-hydroxybutyrate and acetoacetate, fuel the brain during starvation, fasting and strenuous exercise...
April 11, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29672446/the-effects-of-treadmill-exercise-on-autophagy-in-hippocampus-of-app-ps1-transgenic-mice
#13
Na Zhao, Xianliang Zhang, Chenghui Song, Youcai Yang, Biao He, Bo Xu
The β-amyloid (Aβ) deposition is one of the major pathological hallmark of Alzheimer's disease. Dysfunction in autophagy has been reported to lead to the Aβ deposition. The current study aimed to investigate the effects of treadmill exercise on autophagy activity and the Aβ deposition and to demonstrate whether exercise-induced reduction in the Aβ deposition was associated with changes in autophagy activity. APP/PS1 transgenic mice were divided into transgenic sedentary (TG-SED, n=12) and transgenic exercise (TG-EXE, n=12) groups...
April 18, 2018: Neuroreport
https://www.readbyqxmd.com/read/29662895/heme-oxygenase-1-activity-as-a-correlate-to-exercise-mediated-amelioration-of-cognitive-decline-and-neuropathological-alterations-in-an-aging-rat-model-of-dementia
#14
Andrea Kurucz, Mariann Bombicz, Rita Kiss, Dániel Priksz, Balázs Varga, Tibor Hortobágyi, György Trencsényi, Renáta Szabó, Anikó Pósa, Rudolf Gesztelyi, Zoltán Szilvássy, Béla Juhász
Alzheimer's disease (AD) is a neurodegenerative disorder with cognitive impairment. Physical exercise has long been proven to be beneficial in the disorder. The present study was designed to examine the effect of voluntary exercise on spatial memory, imaging, and pathological abnormalities. Particular focus has been given to the role of heme oxygenase-1 (HO-1)-an important cellular cytoprotectant in preserving mental acuity-using an aging rat model of dementia. Male and female Wistar rats were segregated into six groups-namely, (i) aged sedentary (control) females (ASF, n = 8); (ii) aged sedentary (control) males (ASM, n = 8); (iii) aged running females (ARF, n = 8); (iv) aged running males (ARM, n = 8); (v) young control females (YCF, n = 8); and (vi) young control males (YCM, n = 8)...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29604402/effects-of-aquatic-and-land-based-exercises-on-amyloid-beta-heat-shock-protein-27-and-pulse-wave-velocity-in-elderly-women
#15
Ji-Hyeon Kim, Young-Suk Jung, Jong-Won Kim, Min-Seong Ha, Soo-Min Ha, Do-Yeon Kim
BACKGROUND: Alzheimer's disease is a neurodegenerative brain disease resulting from the deterioration of neuronal cells and vascular dementia, the latter of which results from cerebrovascular disorders. Exercise is effective in preventing and treating degenerative brain diseases as it activates blood flow to the brain, increases nerve production in the hippocampus, and promotes the expression of synaptic plasticity-related proteins. Therefore, this study investigated the effects of 16-week aquatic and land-based exercise programs on amyloid beta (Aβ), heat shock protein (HSP) 27 levels, and pulse wave velocity (PWV)...
March 28, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29580264/improving-recovery-and-outcomes-every-day-after-the-icu-improve-study-protocol-for-a-randomized-controlled-trial
#16
Sophia Wang, Jessica Hammes, Sikandar Khan, Sujuan Gao, Amanda Harrawood, Stephanie Martinez, Lyndsi Moser, Anthony Perkins, Frederick W Unverzagt, Daniel O Clark, Malaz Boustani, Babar Khan
BACKGROUND: Delirium affects nearly 70% of older adults hospitalized in the intensive care unit (ICU), and many of those will be left with persistent cognitive impairment or dementia. There are no effective and scalable recovery models to remediate ICU-acquired cognitive impairment and its attendant elevated risk for dementia or Alzheimer disease (AD). The Improving Recovery and Outcomes Every Day after the ICU (IMPROVE) trial is an ongoing clinical trial which evaluates the efficacy of a combined physical exercise and cognitive training on cognitive function among ICU survivors 50 years and older who experienced delirium during an ICU stay...
March 27, 2018: Trials
https://www.readbyqxmd.com/read/29568075/inhibition-of-endothelial-nitric-oxide-synthase-reverses-the-effect-of-exercise-on-improving-cognitive-function-in-hypertensive-rats
#17
Liying Zhang, Haiqing Zheng, Jing Luo, Lili Li, Xiaona Pan, Ting Jiang, Chongjun Xiao, Zhong Pei, Xiquan Hu
Hypertension-induced endothelial dysfunction is associated with β-amyloid (Aβ) deposition, a typical pathology of Alzheimer's disease (AD). Endothelial nitric oxide synthase (eNOS) phosphorylation, impaired by phosphatidylinositol 3-kinase (PI3K)/protein kinase-B(Akt) pathway abnormalities in hypertensive rats, has a critical role in endothelial function. However, it is unknown whether eNOS participates in the hypertension-induced pathology of AD. In this study, we investigated the role of eNOS in Aβ deposition and cognitive function in stroke-prone spontaneously hypertensive (SHRSP) rats...
March 22, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29564062/protein-protein-interaction-analysis-of-alzheimer-s-disease-and-nafld-based-on-systems-biology-methods-unhide-common-ancestor-pathways
#18
Reza Karbalaei, Marzieh Allahyari, Mostafa Rezaei-Tavirani, Hamid Asadzadeh-Aghdaei, Mohammad Reza Zali
Aim: Analysis reconstruction networks from two diseases, NAFLD and Alzheimer`s diseases and their relationship based on systems biology methods. Background: NAFLD and Alzheimer`s diseases are two complex diseases, with progressive prevalence and high cost for countries. There are some reports on relation and same spreading pathways of these two diseases. In addition, they have some similar risk factors, exclusively lifestyle such as feeding, exercises and so on...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29562536/update-on-vascular-cognitive-impairment-associated-with-subcortical-small-vessel-disease
#19
Anders Wallin, Gustavo C Román, Margaret Esiri, Petronella Kettunen, Johan Svensson, George P Paraskevas, Elisabeth Kapaki
Subcortical small-vessel disease (SSVD) is a disorder well characterized from the clinical, imaging, and neuropathological viewpoints. SSVD is considered the most prevalent ischemic brain disorder, increasing in frequency with age. Vascular risk factors include hypertension, diabetes, hyperlipidemia, elevated homocysteine, and obstructive sleep apnea. Ischemic white matter lesions are the hallmark of SSVD; other pathological lesions include arteriolosclerosis, dilatation of perivascular spaces, venous collagenosis, cerebral amyloid angiopathy, microbleeds, microinfarcts, lacunes, and large infarcts...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29557723/in-silico-identification-and-design-of-potent-peptide-inhibitors-against-pdz-3-domain-of-postsynaptic-density-protein-psd-95
#20
Tanuj Sharma, Mohammad Imran Siddiqi
Unique intrinsic properties of peptides like low toxicity, high biological activity, and specificity make them attractive therapeutic agents. PDZ-binding peptide inhibitors have been demonstrated for curing of Alzheimer, Parkinson, Dementia, and other central nervous system ailments. In this article, we report the successful use of an integrated computational protocol to analyze the structural basis of how peptides bind to the shallow groove of the third PDZ domain (PDZ-3) from the postsynaptic density (PSD-95) protein...
April 11, 2018: Journal of Biomolecular Structure & Dynamics
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