keyword
https://read.qxmd.com/read/38458465/effects-and-mechanisms-of-polycyclic-aromatic-hydrocarbons-in-inflammatory-skin-diseases
#21
REVIEW
Hui Jin, Ziyuan Lin, Tianyi Pang, Jingwen Wu, Cheng Zhao, Ying Zhang, Yu Lei, Qilin Li, Xu Yao, Ming Zhao, Qianjin Lu
Polycyclic aromatic hydrocarbons (PAHs) are hydrocarbons characterized by the presence of multiple benzene rings. They are ubiquitously found in the natural environment, especially in environmental pollutants, including atmospheric particulate matter, cigarette smoke, barbecue smoke, among others. PAHs can influence human health through several mechanisms, including the aryl hydrocarbon receptor (AhR) pathway, oxidative stress pathway, and epigenetic pathway. In recent years, the impact of PAHs on inflammatory skin diseases has garnered significant attention, yet many of their underlying mechanisms remain poorly understood...
March 6, 2024: Science of the Total Environment
https://read.qxmd.com/read/38454972/phenotypical-and-molecular-assessments-on-the-pharmacological-effects-of-curcumin-in-drosophila-melanogaster
#22
JOURNAL ARTICLE
Nur R Rumata, Dewi Purwaningsih, Asbah Asbah, Muh Fadhil As'ad, Deepak Chadran, Talha B Emran, Firzan Nainu
Curcumin, a dietary polyphenol derived from turmeric's rhizome, exhibits a range of pharmacological activities, such as antioxidant, analgesic, antipyretic, and anti-inflammatory effects. It has been investigated for its therapeutic potential in chronic obstructive pulmonary disease (COPD) due to its ability to inhibit nuclear factor kappa B (NF-κB), modulate oxidative stress, impact cell viability, and regulate gene expression. However, most studies have been limited to in vitro conditions. To address this gap, we conducted in vivo experiments using the fruit fly Drosophila melanogaster to explore the antioxidant activities and biological significance of curcumin...
August 2023: Narra J
https://read.qxmd.com/read/38454416/apolipoprotein-a-iv-concentrations-and-cancer-in-a-large-cohort-of-chronic-kidney-disease-patients-results-from-the-gckd-study
#23
JOURNAL ARTICLE
Barbara Kollerits, Simon Gruber, Inga Steinbrenner, Johannes P Schwaiger, Hansi Weissensteiner, Sebastian Schönherr, Lukas Forer, Fruzsina Kotsis, Ulla T Schultheiss, Heike Meiselbach, Christoph Wanner, Kai-Uwe Eckardt, Florian Kronenberg
BACKGROUND: Chronic kidney disease (CKD) is highly connected to inflammation and oxidative stress. Both favour the development of cancer in CKD patients. Serum apolipoprotein A-IV (apoA-IV) concentrations are influenced by kidney function and are an early marker of kidney impairment. Besides others, it has antioxidant and anti-inflammatory properties. Proteomic studies and small case-control studies identified low apoA-IV as a biomarker for various forms of cancer; however, prospective studies are lacking...
March 7, 2024: BMC Cancer
https://read.qxmd.com/read/38452750/-air-that-once-was-breath-part-1-wildfire-smoke-induced-mechanisms-of-airway-inflammation-climate-change-allergy-and-immunology-special-iaai-article-collection-collegium-internationale-allergologicum-update-2023
#24
REVIEW
Willis S Bowman, Rebecca J Schmidt, Gursharan K Sanghar, George R Thompson Iii, Hong Ji, Amir A Zeki, Angela Haczku
BACKGROUND: Wildfires are a global concern due to their wide-ranging environmental, economic, and public health impacts. Climate change contributes to an increase in the frequency and intensity of wildfires making smoke exposure a more significant and recurring health concern for individuals with airway diseases. Some of the most prominent effects of wildfire smoke exposure are asthma exacerbations and allergic airway sensitization. Likely due to the delayed recognition of its health impacts in comparison with cigarette smoke and industrial or traffic-related air pollution, research on the composition, the mechanisms of toxicity, and the cellular/molecular pathways involved is poor or non-existent...
March 7, 2024: International Archives of Allergy and Immunology
https://read.qxmd.com/read/38419025/glutathione-s-transferase-m1-t1-and-p1-polymorphisms-and-periodontitis-in-a-caucasian-population-a-case-control-study
#25
JOURNAL ARTICLE
Pavla Izakovicova, Antonin Fassmann, Ladislav Dusek, Lydie Izakovicova Holla
BACKGROUND: Glutathione S-transferases (GSTs) play important roles in protecting cells against oxidative stress and toxic chemicals. This study aimed to investigate the distribution of GSTM1, GSTT1, and GSTP1 variants and their roles in periodontitis susceptibility in a Caucasian population. METHODS: We analyzed 406 participants, including 204 healthy controls and 203 periodontitis patients. A multiplex polymerase chain reaction (PCR) approach was used to analyze GSTM1 and GSTT1 loci...
February 28, 2024: BMC Oral Health
https://read.qxmd.com/read/38417511/the-firestorm-within-a-narrative-review-of-extreme-heat-and-wildfire-smoke-effects-on-brain-health
#26
REVIEW
Anthony R White
Climate change is generating increased heatwaves and wildfires across much of the world. With these escalating environmental changes comes greater impacts on human health leading to increased numbers of people suffering from heat- and wildfire smoke-associated respiratory and cardiovascular impairment. One area of health impact of climate change that has received far less attention is the effects of extreme heat and wildfire smoke exposure on human brain health. As elevated temperatures, and wildfire-associated smoke, are increasingly experienced simultaneously over summer periods, understanding this combined impact is critical to management of human health especially in the elderly, and people with dementia, and other neurological disorders...
February 26, 2024: Science of the Total Environment
https://read.qxmd.com/read/38416185/increased-cardiovascular-risk-in-patients-with-chronic-kidney-disease
#27
REVIEW
Sonja Vondenhoff, Stefan J Schunk, Heidi Noels
Cardiovascular disease (CVD) is highly prevalent in patients suffering from chronic kidney disease (CKD). The risk of patients with CKD developing CVD is manifested already in the early stages of CKD development. The impact of declined kidney function on increased cardiovascular risk and the underlying mechanisms are complex and multifactorial. This review discusses the impact of (a) traditional cardiovascular risk factors such as smoking, dyslipidemia, diabetes, and hypertension as well as (b) CKD-specific pathophysiological and molecular mechanisms associated with an increased cardiovascular risk...
February 28, 2024: Herz
https://read.qxmd.com/read/38414073/dermal-thirdhand-smoke-exposure-induced-epidermal-alterations-in-human-keratinocyte-cells-through-oxidative-damage-and-mmp-1-expression
#28
JOURNAL ARTICLE
Rengin Reis, Kubra Kolci, Eda Nil Yedikardes, Goknil Pelin Coskun, Yasemin Uzuner
Thirdhand smoke (THS) is the residual cigarette smoke that settles on indoor surface fabrics, dust and can accumulate in the environment. Therefore, it can be a risk factor for individuals who have frequent dermal contact with THS-contaminated surfaces. In the present study, it was aimed to elucidate the toxicity of dermal THS exposure in HaCaT human keratinocytes. The THS was extracted from terrycloth exposed to 3R4F research cigarette smoke in a closed chamber and the adverse outcomes induced by THS were determined through assessment of cytotoxicity tests (MTT and NRU), intracellular GSH level, total SOD activity, matrix metalloproteinase-1 (MMP-1) and IL-6 levels...
February 2024: Experimental Dermatology
https://read.qxmd.com/read/38410585/research-progress-of-mitochondria-in-chronic-obstructive-pulmonary-disease-a-bibliometric-analysis-based-on-the-web-of-science-core-collection
#29
JOURNAL ARTICLE
Naer An, Jing An, Tingting Zeng, Shuyan Wang, Ping Li, Xueru Hu, Yongchun Shen, Lian Liu, Fuqiang Wen
BACKGROUND: Due to its high morbidity and mortality, chronic obstructive pulmonary disease (COPD) has become a major global healthcare issue. Although there is abundant research regarding COPD, a bibliometric analysis of the literature related to mitochondria and COPD is lacking. Thus this study aimed to summarize the research status, research direction, and research hotspots of the published articles concerning COPD and mitochondria. METHODS: A literature search for included publications related to COPD and mitochondria was carried out on the Web of Science Core Collection from the date of database establishment to December 15, 2022...
January 30, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38410096/effect-of-honey-and-aqueous-garlic-extracts-against-short-term-exposure-of-cigarette-tobacco-smoking-in-mice-histopathological-and-biochemical-investigations
#30
JOURNAL ARTICLE
Ziad Shraideh, Darwish Badran, Ahmed Alzbeede
It is well known that cigarette smoking adversely affects human health and induces oxidative stress in most vital organs. This study aims to assess the biochemical, histological, and ultrastructural values of honey and garlic extracts in ameliorating the effects of short-term exposure to cigarette smoke in mice. Forty-eight mice were randomly divided into six equal groups: group I was exposed to fresh air only, group II was exposed to cigarette smoke, group III was given 0.2 ml of honey extract, group IV was exposed to cigarette smoke and was given 0...
2024: Journal of Toxicology
https://read.qxmd.com/read/38397950/cutaneous-redox-senescence
#31
REVIEW
Mariáurea Matias Sarandy, Reggiani Vilela Gonçalves, Giuseppe Valacchi
Our current understanding of skin cell senescence involves the role of environmental stressors (UV, O3 , cigarette smoke, particulate matter, etc.), lifestyle (diet, exercise, etc.) as well as genetic factors (metabolic changes, hormonal, etc.). The common mechanism of action of these stressors is the disturbance of cellular redox balance characterized by increased free radicals and reactive oxygen species (ROS), and when these overload the intrinsic antioxidant defense system, it can lead to an oxidative stress cellular condition...
February 1, 2024: Biomedicines
https://read.qxmd.com/read/38394073/comparison-of-the-effects-of-active-and-passive-smoking-of-tobacco-cigarettes-electronic-nicotine-delivery-systems-and-tobacco-heating-products-on-the-expression-and-secretion-of-oxidative-stress-and-inflammatory-response-markers-a-systematic-review
#32
REVIEW
Paulina Natalia Kopa-Stojak, Rafal Pawliczak
OBJECTIVES: This work attempts to summarize current knowledge on the effects of active and passive smoking of cigarettes, electronic nicotine delivery systems and tobacco heating products on the expression and secretion of oxidative stress and inflammatory response mediators, and on their possible impact on chronic obstructive pulmonary disease development. MATERIALS AND METHODS: The literature was searched by the terms: 'smoking', 'active smoking', 'passive smoking', 'main-stream smoke', 'side-stream smoke', 'secondhand smoke', 'cigarette' 'THP', 'tobacco heating product', 'ENDS', 'electronic nicotine delivery system', 'e-cigarette', 'electronic cigarette', oxidative stress', inflammatory response' and 'gene expression'...
February 23, 2024: Inhalation Toxicology
https://read.qxmd.com/read/38393224/evaluation-of-cytotoxicity-and-oxidative-stress-of-whole-aerosol-from-vuse-alto-ends-products
#33
JOURNAL ARTICLE
Brian M Keyser, Robert Leverette, John Wertman, Tom Shutsky, Reagan McRae, Ken Szeliga, Patrudu Makena, Kristen Jordan
Assessment of in vitro cytotoxicity is an important component of tobacco product toxicological evaluations. However, current methods of regulatory testing involve exposing monolayer cell cultures to various preparations of aerosols from cigarettes or other emerging products such as electronic nicotine delivery systems (ENDS), which are not representative of human exposure. In the present study, a whole aerosol (WA) system was used to expose lung epithelial cultures (2D and 3D) to determine the potential of six Vuse Alto ENDS products that varied in nicotine content (1...
February 4, 2024: Toxics
https://read.qxmd.com/read/38393223/metabolomics-provides-novel-insights-into-the-potential-toxicity-associated-with-heated-tobacco-products-electronic-cigarettes-and-tobacco-cigarettes-on-human-bronchial-epithelial-beas-2b-cells
#34
JOURNAL ARTICLE
Marie Lenski, Gianni Zarcone, Saïd Maallem, Guillaume Garçon, Jean-Marc Lo-Guidice, Delphine Allorge, Sébastien Anthérieu
Smoking is an established risk factor for various pathologies including lung cancer. Electronic cigarettes (e-cigs) and heated tobacco products (HTPs) have appeared on the market in recent years, but their safety or, conversely, their toxicity has not yet been demonstrated. This study aimed to compare the metabolome of human lung epithelial cells exposed to emissions of e-cigs, HTPs, or 3R4F cigarettes in order to highlight potential early markers of toxicity. BEAS-2B cells were cultured at the air-liquid interface and exposed to short-term emissions from e-cigs set up at low or medium power, HTPs, or 3R4F cigarettes...
February 4, 2024: Toxics
https://read.qxmd.com/read/38392631/decrease-in-sperm-parameters-in-the-21st-century-obesity-lifestyle-or-environmental-factors-an-updated-narrative-review
#35
REVIEW
Romualdo Sciorio, Luca Tramontano, Mohammed Adel, Steven Fleming
Semen quality represents a compelling factor for fertility, and delineating the normal values has proven difficult. In the last four decades, several authors have reported a noticeable decline in sperm parameters. Also, studies investigating 'time to pregnancy' have shown that fecundity begins to be reduced when sperm numbers decrease below 30 million, even though according to the 6th edition of the WHO manual, the normal value is currently 16 million/mL or 39 million per ejaculate. There exists sufficient data to suggest a decline in sperm counts over time, even though the clear reason for this adverse trend is not well established, but some associations have been hypothesised, such as maternal smoking during pregnancy...
February 11, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38383951/effects-of-acute-sleep-deprivation-on-the-physiological-response-to-woodsmoke-and-exercise
#36
JOURNAL ARTICLE
Joseph A Sol, Anna C Covington, Aidan D A McCloy, Izaac P Sessums, Elias M Malek, Graham R McGinnis, John C Quindry
OBJECTIVE: Evaluate sleep deprivation effects on the acute physiological response to a combined stressor of woodsmoke and exercise. METHODS: Ten participants completed two exercise trials (8 hr of sleep vs. 4 hr) with woodsmoke. Trials were conducted in a crossover design. Key measures examined before and after each trial included heart rate variability (HRV), pulse wave velocity (PWV), blood pressure (BP), pulmonary function testing (PFT), and oxidative stress...
February 22, 2024: Journal of Occupational and Environmental Medicine
https://read.qxmd.com/read/38383671/elevated-serum-levels-of-leukocyte-cell-derived-chemotaxin-2-are-associated-with-the-prevalence-of-metabolic-syndrome
#37
JOURNAL ARTICLE
Xialei Zheng, Junmi Lu, Shaojun Xiang, Pu Zou, Hao Chen, Jing Liu, Cheng Zeng, Yuhu He
AIMS: Inflammation is central to the pathogenesis of metabolic syndrome (MetS). Leukocyte cell-derived chemotaxin 2 (LECT2) is constitutively secreted in response to inflammatory stimuli and oxidative stress contributing to tissue or systemic inflammation. We explored the relationship between LECT2 levels and MetS severity in humans and mice. METHODS: Serum LECT2 levels were measured in 210 participants with MetS and 114 without MetS (non-MetS). LECT2 expression in the liver and adipose tissue was also examined in mice fed a high-fat diet (HFD) and genetically obese (ob/ob) mice...
February 22, 2024: Acta Diabetologica
https://read.qxmd.com/read/38378599/incremental-values-of-aopp-il-6-and-gdf15-for-identifying-arteriosclerosis-in-patients-with-obstructive-sleep-apnea
#38
JOURNAL ARTICLE
Xinxin Li, Wen Liu, Yonghuai Wang, Cuiting Zhao, Qing Zhu, Zhishuang Dong, Chunyan Ma
BACKGROUND: The objective of this study was to determine the independent and incremental values of advanced oxidative protein product (AOPP), interleukin 6 (IL-6), and growth differentiation factor 15 (GDF15) in identifying arteriosclerosis in patients with obstructive sleep apnea (OSA). METHODS: A total of 104 individuals diagnosed with OSA by polysomnography were recruited in our study. Arteriosclerosis was defined by measuring the ultrafast pulse wave velocity of the carotid artery...
February 20, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38376817/systemic-and-local-effect-of-oxidative-stress-on-recurrent-aphthous-stomatitis-systematic-review
#39
REVIEW
Cristina Estornut, Giulia Rinaldi, María Carmen Carceller, Sergio Estornut, Martín Pérez-Leal
Recurrent aphthous stomatitis (RAS) is a chronic and recurrent inflammatory disease of the mouth. It is characterised by the appearance of painful ulcers in the oral mucosa. RAS is believed to be a multifactorial disease with genetic predisposition, environmental factors and alterations in the immune system. Oxidative stress, caused by an imbalance between free radicals and the antioxidant system, also appears to be involved in the pathogenesis of RAS. Several risk factors, such as smoking, iron and vitamin deficiency and anxiety, may contribute to the development of the disease...
February 20, 2024: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/38376568/electronic-cigarettes-and-cardiovascular-disease-epidemiological-and-biological-links
#40
REVIEW
Huiqi Zong, Zhekai Hu, Weina Li, Mina Wang, Qi Zhou, Xiang Li, Hongxu Liu
Electronic cigarettes (e-cigarettes), as alternative nicotine delivery methods, has rapidly increased among youth and adults in recent years. However, cardiovascular safety is an important consideration regarding e-cigarettes usage. e-cigarette emissions, including nicotine, propylene glycol, flavorings, nitrosamine, and metals, might have adverse effects on cardiovascular health. A large body of epidemiological evidence has indicated that e-cigarettes are considered an independent risk factor for increased rates of cardiovascular disease occurrence and death...
February 20, 2024: Pflügers Archiv: European Journal of Physiology
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