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Smoking and oxidative stress

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https://www.readbyqxmd.com/read/28731859/air-pollution-and-parkinson-s-disease-evidence-and-future-directions
#1
REVIEW
Natalia Palacios
Parkinson's disease (PD) is a neurodegenerative disease of unknown etiology that is thought to be caused by a complex combination of environmental and/or genetic factors. Air pollution exposure is linked to numerous adverse effects on human health, including brain inflammation and oxidative stress, processes that are believed to contribute to the development and progression of PD. This review provides an overview of recent advances in the epidemiology of air pollution and PD, including evidence of the effects of various pollutants (ozone, PM10, PM2...
July 21, 2017: Reviews on Environmental Health
https://www.readbyqxmd.com/read/28725903/suppressive-effects-of-dietary-epa-rich-fish-oil-on-the-degradation-of-elastin-fibers-in-the-aortic-wall-in-nicotine-administered-mice
#2
Hirona Kugo, Nobuhiro Zaima, Megumi Onozato, Chie Miyamoto, Keisuke Hashimoto, Kenichi Yanagimoto, Tatsuya Moriyama
Abdominal aortic aneurysm (AAA) is a vascular disease involving gradual dilation of the abdominal aorta. Recent studies suggest that nicotine, which is a primary component in cigarette smoke, is closely associated with the development and rupture of an AAA. Nicotine accelerates AAA development through the weakening of the vascular wall by increasing oxidative stress and matrix metalloproteinase (MMP)-2 expression. However, little is known about preventing the AAA induced by nicotine. A non-surgical means of preventing the weakening of the vascular wall before the onset of AAA by functional food factors would be a valuable option over surgery...
July 20, 2017: Food & Function
https://www.readbyqxmd.com/read/28716263/exogenous-acrolein-intensifies-sensory-hypersensitivity-after-spinal-cord-injury-in-rat
#3
Breanne Butler, Glen Acosta, Riyi Shi
Acrolein, an α,β-unsaturated aldehyde associated with oxidative stress, is also a major toxic component of tobacco cigarette smoke, which has been reported in the clinic to coincide with the exacerbation of neuropathic pain after SCI. Previous reports have shown that acrolein involvement in spinal cord injury (SCI) is crucial to the development and persistence of neuropathic pain. Through the activation and upregulation of the transient receptor protein ankyrin-1 (TRPA1) cation channel, acrolein is capable of sensitizing the central nervous system in the acute and chronic stages of SCI...
August 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28715576/association-of-ozone-exposure-with-cardiorespiratory-pathophysiologic-mechanisms-in-healthy-adults
#4
Drew B Day, Jianbang Xiang, Jinhan Mo, Feng Li, Mingkei Chung, Jicheng Gong, Charles J Weschler, Pamela A Ohman-Strickland, Jan Sundell, Wenguo Weng, Yinping Zhang, Junfeng Jim Zhang
Importance: Exposure to ozone has been associated with cardiovascular mortality, but the underlying biological mechanisms are not yet understood. Objective: To examine the association between ozone exposure and cardiopulmonary pathophysiologic mechanisms. Design, Setting, and Participants: A longitudinal study involving 89 healthy adult participants living on a work campus in Changsha City, China, was conducted from December 1, 2014, to January 31, 2015...
July 17, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28713991/pien-tze-huang-gan-bao-attenuates-carbon-tetrachloride%C3%A2-induced-hepatocyte-apoptosis-in-rats-associated-with-suppression-of-p53-activation-and-oxidative-stress
#5
Jinyan Zhao, Yuchen Zhang, Yun Wan, Haixia Hu, Zhenfeng Hong
Pien Tze Huang Gan Bao (PZH‑GB), a traditional Chinese medicine, has been used for thousands of years as a protective remedy effective against liver injury induced by excessive alcohol and smoking. The present study aimed to evaluate the protective effects and potential mechanisms of PZH‑GB against carbon tetrachloride (CCl4)‑induced hepatic injury. Rats were pre‑treated with silymarin (50 mg/kg) or different doses of PZH‑GB (150, 300 or 600 mg/kg) orally administered for 7 days. At the end of treatment, the rats were intraperitoneally injected with CCl4, or control rats received a corn oil injection...
July 6, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28711174/secondhand-smoke-exposure-and-preclinical-markers-of-cardiovascular-risk-in-toddlers
#6
Judith A Groner, Hong Huang, Mandar S Joshi, Nicholas Eastman, Lisa Nicholson, John Anthony Bauer
OBJECTIVE: To investigate relationships between secondhand smoke exposure in young children and several preclinical markers of cardiovascular risk that have been established as relevant to adult populations. STUDY DESIGN: There were 139 children, 2-5 years of age, enrolled in a cross-sectional study. Secondhand smoke exposure was objectively determined by hair nicotine level; a comprehensive panel of clinical markers (morning blood pressure, fasting glucose and insulin, lipid profiles, inflammation) and research markers (markers of oxidation, endothelial stress, and endothelial repair) of cardiovascular risk status were assessed...
July 12, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28702879/assessment-of-genotoxicity-amongst-smokers-alcoholics-and-tobacco-chewers-of-north-india-using-micronucleus-assay-and-urinary-8-hydroxyl-2-deoxyguanosine-as-biomarkers
#7
S V S Rana, Yeshvandra Verma, Gagan Deep Singh
The main objective of the present study was to screen the genotoxicity caused by individual and combined habits of smoking, tobacco chewing, and alcohol consumption in human population of North India. Study recruited 67 male subjects aged 25 to 65 years. Buccal mucosal cells were subjected to micronucleus (MN) assay, and 8-hydroxyl-2-deoxyguanosine (8-OHdG) was estimated in their urine samples. Number and shape of the MN cells varied in the buccal epithelium of different groups. Maximum number of MN (0.47%) were found in tobacco chewers followed by smokers (0...
August 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28700458/perceived-stress-depressive-symptoms-and-oxidative-dna-damage
#8
Chisato Shimanoe, Megumi Hara, Yuichiro Nishida, Hinako Nanri, Mikako Horita, Yosuke Yamada, Yun-Shan Li, Hiroshi Kasai, Kazuaki Kawai, Yasuki Higaki, Keitaro Tanaka
OBJECTIVE: Psychosocial stress may influence the risk of disease through its association with oxidative DNA damage. We examined whether perceived stress and depressive symptoms were associated with urinary excretion of 8-hydroxydeoxyguanosine (8-OHdG), with mutual interaction on 8-OHdG. METHODS: This cross-sectional study included 6,517 individuals aged 45-74 years who participated, between 2010 and 2012, in a follow-up survey of an ongoing cohort study. Perceived stress during the past year was measured using a self-report questionnaire...
July 12, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28692419/long-term-cigarette-smoke-exposure-and-changes-in-mirna-expression-and-proteome-in-non-small-cell-lung-cancer
#9
Jayshree Advani, Yashwanth Subbannayya, Krishna Patel, Aafaque Ahmad Khan, Arun H Patil, Ankit P Jain, Hitendra S Solanki, Aneesha Radhakrishnan, Sneha M Pinto, Nandini A Sahasrabuddhe, Joji K Thomas, Premendu P Mathur, Bipin G Nair, Xiaofei Chang, T S Keshava Prasad, David Sidransky, Harsha Gowda, Aditi Chatterjee
Chronic exposure to cigarette smoke markedly increases the risk for lung cancer. Regulation of gene expression at the post-transcriptional level by miRNAs influences a variety of cancer-related interactomes. Yet, relatively little is known on the effects of long-term cigarette smoke exposure on miRNA expression and gene regulation. NCI-H292 (H292) is a cell line sensitive to cigarette smoke with mucoepidermoid characteristics in culture. We report, in this study, original observations on long-term (12 months) cigarette smoke effects in the H292 cell line, using microarray-based miRNA expression profiling, and stable isotopic labeling with amino acids in cell culture-based quantitative proteomic analysis...
July 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/28692121/molecular-analysis-of-the-gstt1-gene-polymorphism-in-patients-with-clinical-manifestation-of-atherosclerosis
#10
J V M Martins, D A Rodrigues, K S F Silva, I R Costa, M H Lagares, F L Campedelli, A M Barbosa, M P Morais, K K V O Moura
Atherosclerosis is a chronic inflammatory disease formed by the accumulation of lipids in the innermost layer and large-caliber artery (tunica intima). This accumulation, along with platelet factors, stimulates the proliferation of muscle cells in this region. Over than 400 genes may be related to the pathology since they regulate endothelial function, coagulation, inflammation, metabolism of amino acids, lipids, and carbohydrates. Glutathione S-transferases (GST) are enzymes that catalyze the polymorphic detoxification of metabolites produced by oxidative stress within the cells, which is induced by reactive oxygen species...
July 6, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28684161/vitamin-e-isoform-%C3%AE-tocotrienol-protects-against-emphysema-in-cigarette-smoke-induced-copd
#11
Hong Yong Peh, W S Daniel Tan, Tze Khee Chan, Chen Wei Pow, Paul S Foster, W S Fred Wong
Inflammation and oxidative stress contribute to emphysema in COPD. Although corticosteroids are the standard of care for COPD, they do not reduce oxidative stress, and a subset of patients is steroid-resistant. Vitamin E isoform γ-tocotrienol possesses both anti-inflammatory and anti-oxidative properties that may protect against emphysema. We aimed to establish the therapeutic potential of γ-tocotrienol in cigarette smoke-induced COPD models in comparison with prednisolone. BALB/c mice were exposed to cigarette smoke for 2 weeks or 2 months...
July 3, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28683970/oxidative-stress-and-cardiovascular-risk-obesity-diabetes-smoking-and-pollution-part-3-of-a-3-part-series
#12
REVIEW
Bernd Niemann, Susanne Rohrbach, Mark R Miller, David E Newby, Valentin Fuster, Jason C Kovacic
Oxidative stress occurs whenever the release of reactive oxygen species (ROS) exceeds endogenous antioxidant capacity. In this paper, we review the specific role of several cardiovascular risk factors in promoting oxidative stress: diabetes, obesity, smoking, and excessive pollution. Specifically, the risk of developing heart failure is higher in patients with diabetes or obesity, even with optimal medical treatment, and the increased release of ROS from cardiac mitochondria and other sources likely contributes to the development of cardiac dysfunction in this setting...
July 11, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28681937/maternal-nicotine-exposure-leads-to-decreased-cardiac-protein-disulfide-isomerase-and-impaired-mitochondrial-function-in-male-rat-offspring
#13
Nicole G Barra, Maria Lisyansky, Taylor A Vanduzer, Sandeep Raha, Alison C Holloway, Daniel B Hardy
Smoking throughout pregnancy can lead to complications during gestation, parturition and neonatal development. Thus, nicotine replacement therapies are a popular alternative thought to be safer than cigarettes. However, recent studies in rodents suggest that fetal and neonatal nicotine exposure alone results in cardiac dysfunction and high blood pressure. While it is well known that perinatal nicotine exposure causes increased congenital abnormalities, the mechanisms underlying longer-term deficits in cardiac function are not completely understood...
July 6, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28674322/oxidative-stress-is-closely-associated-with-increased-arterial-stiffness-especially-in-aged-male-smokers-without-previous-cardiovascular-events-a-cross-sectional-study
#14
Tomonori Sugiura, Yasuaki Dohi, Hiroyuki Takase, Sumiyo Yamashita, Satoshi Fujii, Nobuyuki Ohte
AIM: Cigarette smoking is one of the major risk factors for cardiovascular diseases and induces deleterious vascular damage. Oxidative stress is involved in vascular inflammation, the process of atherosclerosis. The purpose of the present study was to investigate whether the effects of oxidative stress on the arterial wall differ between smokers and non-smokers. METHODS: Male smokers and non-smokers without physical deconditioning who visited Enshu hospital for an annual physical check-up were enrolled in the study...
July 1, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28672163/evaluation-of-whole-cigarette-smoke-induced-oxidative-stress-in-a549-and-beas-2b-cells
#15
Shimin Zhang, Xiang Li, Fuwei Xie, Kejian Liu, Huimin Liu, Jianping Xie
Cigarette smoke is a complex and oxidative aerosol. Previous researches on the hazards of cigarette smoke mainly focused on the adverse bioeffects induced by its condensates or gas vapor phase, which ignored the dynamic processes of smoking and the cigarette smoke aging. To overcome these disadvantages, we performed air-liquid interface exposure of whole smoke, which used native and unmodified smoke and ensured the exposure similar to physiological inhalation. Our results indicated that whole cigarette smoke induced lung epithelial cells (A549) and bronchial epithelial cells (BEAS-2B) damages in cytotoxicity assays (methyl thiazoly tetrazolium and neutral red uptake assays)...
June 27, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28671162/study-of-oxidative-stress-biomarkers-in-chronic-obstructive-pulmonary-disease-and-their-correlation-with-disease-severity-in-north-indian-population-cohort
#16
Jyoti Bajpai, Ved Prakash, Surya Kant, Ajay Kumar Verma, Anand Srivastava, Darshan K Bajaj, M K Ahmad, Avinash Agarwal
BACKGROUND: Oxidant-antioxidant imbalance forms a prime component in pathogenesis of chronic obstructive pulmonary disease (COPD). Studies of oxidative stress markers in South Asians were sparse. METHODS: One hundred and eighty COPD patients and eighty healthy nonsmokers were enrolled in the study. Serum malondialdehyde (MDA) and iron levels were estimated for oxidative stress. Three antioxidant markers evaluated-catalase, superoxide dismutase (SOD), and serum copper...
July 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28667909/graphical-review-the-redox-dark-side-of-e-cigarettes-exposure-to-oxidants-and-public-health-concerns
#17
REVIEW
Hua Cai, Chen Wang
Since the initial marketing in 2005, the use of e-cigarettes has increased exponentially. Nonetheless, accumulating evidence has demonstrated the ineffectiveness of e-cigarettes in leading to smoking cessation, and decreasing the adverse health impacts of cigarette smoking. The number of adolescents adapted to e-cigarettes has been increasing substantially each year, and this adaptation has promoted openness to tobacco smoking. The present review discusses controversies regarding the smoking cessation effects of e-cigarettes, recent governmental policies and regulations of e-cigarette use, toxic components and vaporization products of e-cigarettes, and the novel molecular mechanisms underlying the adverse health impacts of e-cigarettes leading to oxidative stress in target tissues, and consequent development of cardiopulmonary diseases (i...
May 25, 2017: Redox Biology
https://www.readbyqxmd.com/read/28665927/age-dependent-sensitivity-of-the-mouse-kidney-to-chronic-nicotine-exposure
#18
Istvan Arany, Samuel Hall, Mehul Dixit
BACKGROUND: Many adolescents are exposed to nicotine via smoking, E-cigarette-use or second-hand-smoke. Nicotine-induced renal oxidative stress and its long-term-consequences may be higher in adolescents than in adults due to intrinsic factors in the adolescent kidney. METHODS: Adolescent and adult male C57Bl/6J mice were subjected to 2 or 200 μg/ml nicotine, which closely emulates passive or active smoking, for 4 weeks. Extent of nicotine exposure (cotinine content), oxidative stress (HNE), renal function (creatinine), tubular injury (KIM-1) and pre-treatment renal levels of select pro- (p66shc) and anti-oxidant (Nrf2/MnSOD) genes were determined...
June 30, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28655550/skin-accumulation-of-advanced-glycation-end-products-is-increased-in-patients-with-an-abdominal-aortic-aneurysm
#19
Jeltje Boersema, Lisanne C de Vos, Thera P Links, Douwe J Mulder, Andries J Smit, Clark J Zeebregts, Joop D Lefrandt
OBJECTIVE: Advanced glycation end products (AGEs) are implicated in the pathogenesis of cardiovascular disease. Accumulation of AGEs is driven by oxidative or glycemic stress and can be assessed by skin autofluorescence (SAF). SAF is increased in patients with peripheral artery disease (PAD) and independently associated with mortality and major adverse cardiovascular events in these patients. PAD and abdominal aortic aneurysm (AAA) share several risk factors. Inflammation is an important process in AAA formation and increases levels of oxidative stress...
June 24, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28655148/genetic-variants-in-the-manganese-superoxide-dismutase-2-gene-and-in-the-catalase-gene-are-not-associated-with-alcoholic-chronic-pancreatitis
#20
Alexander Schneider, Jonas Rosendahl, Peter Bugert, Christel Weiss, Heike Unterschütz, Marja-Leena Kylanpää-Bäck, Marko Lempinen, Esko Kemppainen, Brindusa L Diaconu, Matthias P Ebert, Roland H Pfützer
Aims: Oxidative stress may contribute to the development of chronic pancreatitis (CP). The enzymes manganese superoxide dismutase 2 (MnSOD, SOD2) and catalase (CAT) counteract free radical activity within the mitochondria and the cytosol. Moreover, CAT activity contributes to the transformation of ethanol to acetaldehyde, a toxic intermediate product of ethanol metabolism, which has been associated with pancreatic damage. Common functional polymorphisms have been described in the MnSOD gene [rs4880, NM_000636...
June 26, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
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