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Smoking and oxidative stress

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https://www.readbyqxmd.com/read/28549278/effects-of-varenicline-and-nicotine-replacement-therapy-on-arterial-elasticity-endothelial-glycocalyx-and-oxidative-stress-during-a-3-month-smoking-cessation-program
#1
Ignatios Ikonomidis, Margarita Marinou, Dimitrios Vlastos, Kallirhoe Kourea, Ioanna Andreadou, Nikolaos Liarakos, Helen Triantafyllidi, George Pavlidis, Elias Tsougos, John Parissis, John Lekakis
BACKGROUND AND AIMS: The effects of medically-aided smoking cessation on vascular function and oxidative stress are not fully clarified. METHODS: One hundred eighty-eight current smokers were randomized to varenicline or nicotine replacement treatment (NRT) for a 3-month period. We assessed: (a) augmentation index (Aix) and pulse wave velocity (PWV); (b) perfusion boundary region (PBR) of sublingual microvasculature (range:5-25 μm), an index of the endothelial glycocalyx thickness, using Sideview, Darkfield imaging; (c) the exhaled CO; and (d) the malondialdehyde (MDA) and protein carbonyls (PC) plasma levels, as markers of oxidative stress, at baseline and after 3 and 12 months...
May 13, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28548877/role-of-osgin1-in-mediating-smoking-induced-autophagy-in-the-human-airway-epithelium
#2
Guoqing Wang, Haixia Zhou, Yael Strulovici-Barel, Mohammed Al-Hijji, Xuemei Ou, Jacqueline Salit, Matthew S Walters, Michelle R Staudt, Robert J Kaner, Ronald G Crystal
Enhanced macroautophagy/autophagy is recognized as a component of the pathogenesis of smoking-induced airway disease. Based on the knowledge that enhanced autophagy is linked to oxidative stress and the DNA damage response, both of which are linked to smoking, we used microarray analysis of the airway epithelium to identify smoking upregulated genes known to respond to oxidative stress and the DNA damage response. This analysis identified OSGIN1 (oxidative stress induced growth inhibitor 1) as significantly upregulated by smoking, in both the large and small airway epithelium, an observation confirmed by an independent small airway microarray cohort, TaqMan PCR of large and small airway samples and RNA-Seq of small airway samples...
May 26, 2017: Autophagy
https://www.readbyqxmd.com/read/28533927/antioxidant-and-anti-inflammatory-medicinal-plants-have-potential-role-in-the-treatment-of-cardiovascular-disease-a-review
#3
REVIEW
Peter Adegbola, Ifewumi Aderibigbe, Wasiu Hammed, Tolulope Omotayo
Cardiovascular disease is a compound name for clusters of disorders afflicting the heart and blood vessels; it is assuming an increasing role as a major cause of morbidity and mortality. Unhealthy practices such as smoking, high intake of saturated fat and cholesterol, diabetes and physical inactivity are predisposing factors. The risk factors cause alteration in vascular integrity, compromised membrane integrity, increase free radical generation and reduced endogenous antioxidant system resulting in oxidative stress...
2017: American Journal of Cardiovascular Disease
https://www.readbyqxmd.com/read/28528972/brand-variation-in-oxidant-production-in-mainstream-cigarette-smoke-carbonyls-and-free-radicals
#4
Samantha M Reilly, Reema Goel, Neil Trushin, Ryan J Elias, Jonathan Foulds, Joshua Muscat, Jason Liao, John P Richie
Oxidative stress/damage resulting from exposure to cigarette smoke plays a critical role in the development of tobacco-caused diseases. Carbonyls and free radicals are two major classes of oxidants in tobacco smoke. There is little information on the combined delivery of these oxidants across different cigarette brands; thus, we set out to measure and compare their levels in mainstream smoke from popular US cigarettes. Mainstream smoke from 28 different cigarette brands produced by smoking (FTC protocol) was analyzed for five important, abundant carbonyls, and levels were compared to previously determined free radical for the same brands...
May 18, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28524757/wood-smoke-exposure-of-portuguese-wildland-firefighters-dna-and-oxidative-damage-evaluation
#5
Ana Abreu, Carla Costa, Susana Pinho E Silva, Simone Morais, Maria do Carmo Pereira, Adília Fernandes, Vanessa Moraes de Andrade, João Paulo Teixeira, Solange Costa
Portugal is among the European Union countries most devastated by forest fires each year. In the last three decades, more than 3.8 million hectares of forest were burned. Wildland firefighters are exposed to a variety of hazards, including many toxic combustion products that may lead to deleterious health effects. Epidemiological studies showed a positive association between firefighting and several chronic diseases, including cancer. Results from biomonitoring studies in firefighters, particularly concerning genotoxicity evaluation, constitute a valuable tool for investigating important occupational hazards...
May 19, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28522564/decreased-phosphatase-pten-amplifies-pi3k-signaling-and-enhances-pro-inflammatory-cytokine-release-in-copd
#6
Satoru Yanagisawa, Jonathan R Baker, Chaitanya Vuppusetty, Peter Fenwick, Louise E Donnelly, Kazuhiro Ito, Peter J Barnes
The phosphatidylinositol 3-kinase (PI3K) pathway is activated in chronic obstructive pulmonary disease (COPD), but the regulatory mechanisms for this pathway are yet to be elucidated. Our aim was to determine the expression and role of phosphatase and tensin homolog deleted from chromosome 10 (PTEN), a negative regulator of the PI3K pathway, in COPD. PTEN expression and activity were measured in the peripheral lung of COPD patients compared to smoking and non-smoking controls. The direct influence of cigarette smoke extract (CSE) on PTEN expression was assessed using primary lung epithelial cells and a cell line (BEAS-2B) in the presence or absence of L-buthionine-sulfoximine (BSO) to deplete intracellular glutathione...
May 18, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28522560/the-effect-of-long-term-maternal-smoking-on-the-offspring-s-lung-health
#7
Suporn Sukjamnong, Yik Lung Chan, Razia Zakarya, Sonia Saad, Pawan Sharma, Rachana Santiyanont, Hui Chen, Brian G G Oliver
Maternal smoking during pregnancy contributes to long-term health problems in offspring, especially respiratory disorders which can manifest in either childhood or adulthood. Receptors for advanced glycation end-products (RAGE) are multi-ligand receptors abundantly localized in the lung, capable of responding to by-products of reactive oxygen species and pro-inflammatory responses. RAGE signalling is a key regulator of inflammation in cigarette smoking-related pulmonary diseases. However, the impact of maternal cigarette smoke exposure on lung RAGE signalling in the offspring is unclear...
May 18, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28520939/dietary-intake-of-antioxidant-vitamins-and-carotenoids-and-risk-of-developing-active-tuberculosis-in-a-prospective-population-based-cohort
#8
Avril Z Soh, Cynthia B E Chee, Yee-Tang Wang, Jian-Min Yuan, Woon-Puay Koh
Antioxidants may protect against oxidative stress, which is associated with tuberculosis disease. However, direct evidence for the protective association between dietary antioxidants and tuberculosis incidence in humans has been lacking. The relation between intake of antioxidant vitamins (A, C, D, E) and individual carotenoids (α-carotene, β-carotene, β-cryptoxanthin, lycopene, lutein) and tuberculosis incidence was examined in the Singapore Chinese Health Study, a prospective cohort of 63,257 adults 45-74 years old enrolled during 1993-1998...
May 18, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28511368/evaluation-of-cyp1b1-expression-oxidative-stress-and-phase-2-detoxification-enzyme-status-in-oral-squamous-cell-carcinoma-patients
#9
Shailza Verma, Rahul Saxena, Merajul Haque Siddiqui, Karunathy Santha, Subramaniam Sethupathy
INTRODUCTION: Oral Squamous Cell Carcinoma (OSCC) affects global health with increasing incidence and mortality rate. It may involve exposure to carcinogens from tobacco smoking or chewing. Alteration in expression of gene encoding the enzymes concerned with carcinogen biotransformation along with oxidative stress may increase or decrease the risk of cancer. AIM: To evaluate the expression of CYP1B1 gene in OSCC patients along with its relation with oxidative stress and phase 2 detoxification enzyme status...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28508372/effect-of-second-hand-tobacco-smoke-on-the-nitration-of-brain-proteins-a-systems-biology-and-bioinformatics-approach
#10
Firas H Kobeissy, Joy Guingab-Cagmat, Adriaan W Bruijnzeel, Mark S Gold, Kevin Wang
Second-hand smoke (SHS) exposure leads to the death of approximately 48,000 nonsmokers per year in the United States alone. SHS exposure has been associated with cardiovascular, respiratory, and neurodegenerative diseases. While cardiac function abnormalities and lung cancer due to SHS have been well characterized, brain injury due to SHS has not undergone a full systematic evaluation. Oxidative stress and nitration have been associated with smoking and SHS exposure. Animal studies suggest that exposure to tobacco smoke increases oxidative stress...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28498017/dietary-supplements-as-surrogate-of-mediterranean-diet-in-healthy-smoking-subjects
#11
Sonya Vasto, Giulia Accardi, Anna Aiello, Francesca Di Gaudio, Annalisa Barera, Serena Indelicato, Damiano Galimberti, Emilio Italiano, Roberto Monastero, Claudia Rizzo, Calogero Caruso, Giuseppina Candore
The interventions to slow ageing, favouring active life expectancy, represent the new perspectives in ageing investigation. Some mechanisms that delay or prevent the onset of ageing pathologies have been identified. Between them, a healthy lifestyle seems to reduce many risk factors. In particular, eating habits represent the most concrete, low cost way to act on ageing process. Mediterranean diet has received much attention since it has been consistently demonstrated its anti-oxidant and anti-inflammatory effects...
May 12, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28492872/urinary-isoprostane-levels-and-age-related-macular-degeneration
#12
Charumathi Sabanayagam, Weng Kit Lye, Andrzej Januszewski, Riswana Banu Binte Mohammed Abdul, Gemmy Chui Ming Cheung, Neelam Kumari, Tien Y Wong, Ching-Yu Cheng, Ecosse Lamoureux
Purpose: Oxidative stress, characterized by an excessive production of reactive oxygen intermediates has been suggested to play a role in the pathogenesis of age-related macular degeneration (AMD). We examined the association of urinary F2-isoprostanes (F2-IsoPs), a marker of lipid peroxidation and the most reliable marker of oxidative damage with AMD. Methods: We included 238 adults with AMD and 390 age- and sex-matched controls without AMD who participated in a population-based cross-sectional study in Singapore (Singapore Chinese Eye Study, 2009-2011)...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28486422/the-relationship-between-environmental-tobacco-smoke-exposure-and-cardiovascular-disease-and-the-potential-modifying-effect-of-diet-in-a-prospective-cohort-among-american-indians-the-strong-heart-study
#13
Sarah Rajkumar, Amanda M Fretts, Barbara V Howard, Fawn Yeh, Maggie L Clark
American Indians experience high rates of cardiovascular diseases (CVD). Environmental tobacco smoke (ETS) has been linked to CVD, possibly due to pro-inflammatory and oxidative stress pathways. We examined the relationship between self-reported exposure to ETS and fatal and nonfatal CVD incidence using Cox proportional hazards models among 1843 non-smoking American Indians participating in the Strong Heart Study. We also evaluated potential modifying effects of several dietary nutrients high in anti-inflammatory and anti-oxidant properties with ETS exposure on fatal and nonfatal CVD by creating interaction terms between ETS exposure and the dietary variable...
May 9, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28483577/formoterol-and-fluticasone-propionate-combination-improves-histone-deacetylation-and-anti-inflammatory-activities-in-bronchial-epithelial-cells-exposed-to-cigarette-smoke
#14
M Ferraro, M Gjomarkaj, L Siena, S Di Vincenzo, E Pace
BACKGROUND: The addition of long-acting beta2-agonists (LABAs) to corticosteroids improves asthma control. Cigarette smoke exposure, increasing oxidative stress, may negatively affect corticosteroid responses. The anti-inflammatory effects of formoterol (FO) and fluticasone propionate (FP) in human bronchial epithelial cells exposed to cigarette smoke extracts (CSE) are unknown. AIMS: This study explored whether FP, alone and in combination with FO, in human bronchial epithelial cellline (16-HBE) and primary bronchial epithelial cells (NHBE), counteracted some CSE-mediated effects and in particular some of the molecular mechanisms of corticosteroid resistance...
May 5, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28481369/e-smoking-emerging-public-health-problem
#15
REVIEW
Mateusz Jankowski, Grzegorz Brożek, Joshua Lawson, Szymon Skoczyński, Jan Eugeniusz Zejda
E-cigarette use has become increasingly popular, especially among the young. Its long-term influence upon health is unknown. Aim of this review has been to present the current state of knowledge about the impact of e-cigarette use on health, with an emphasis on Central and Eastern Europe. During the preparation of this narrative review, the literature on e-cigarettes available within the network PubMed was retrieved and examined. In the final review, 64 research papers were included. We specifically assessed the construction and operation of the e-cigarette as well as the chemical composition of the e-liquid; the impact that vapor arising from the use of e-cigarette explored in experimental models in vitro; and short-term effects of use of e-cigarettes on users' health...
May 8, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28481134/the-role-of-oxidative-stress-in-the-clinical-manifestations-of-childhood-asthma
#16
Aleksandra Topic, Djordje Francuski, Aleksandra Nikolic, Katarina Milosevic, Snezana Jovicic, Bojan Markovic, Mirjana Djukic, Dragica Radojkovic
INTRODUCTION: The significance of oxidative stress in pathogenesis of childhood asthma was recognized, but its role in the clinical manifestations of disease is still unclear. MATERIALS AND METHODS: The study was conducted in 96 asthmatic children. The urinary biomarker of oxidative stress, 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxodG/creatinine) was determined by using HPLC-MS/MS. ELISA was performed to measure myeloperoxidase (MPO) and Cu,Zn- superoxide dismutase (Cu,Zn-SOD) in serum...
May 8, 2017: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/28471941/basic-science-and-pathogenesis-of-ageing-with-hiv-potential-mechanisms-and-biomarkers
#17
Claire Lagathu, Andrea Cossarizza, Véronique Béréziat, Milena Nasi, Jacqueline Capeau, Marcello Pinti
: The increased prevalence of age-related comorbidities and mortality is worrisome in ageing HIV-infected patients. Here, we aim to analyse the different ageing mechanisms with regard to HIV infection. Ageing results from the time-dependent accumulation of random cellular damage. Epigenetic modifications and mitochondrial DNA haplogroups modulate ageing. In antiretroviral treatment-controlled patients, epigenetic clock appears to be advanced, and some haplogroups are associated with HIV infection severity. Telomere shortening is enhanced in HIV-infected patients because of HIV and some nucleoside analogue reverse transcriptase inhibitors...
June 1, 2017: AIDS
https://www.readbyqxmd.com/read/28468631/2d-dige-proteomic-analysis-of-vastus-lateralis-from-copd-patients-with-low-and-normal-fat-free-mass-index-and-healthy-controls
#18
Ramzi Lakhdar, Ellen M Drost, William MacNee, Ricardo Bastos, Roberto A Rabinovich
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is associated with several extra-pulmonary effects of which skeletal muscle wasting is one of the most common and contributes to reduced quality of life, increased morbidity and mortality. The molecular mechanisms leading to muscle wasting are not fully understood. Proteomic analysis of human skeletal muscle is a useful approach for gaining insight into the molecular basis for normal and pathophysiological conditions. METHODS: To identify proteins involved in the process of muscle wasting in COPD, we searched differentially expressed proteins in the vastus lateralis of COPD patients with low fat free mass index (FFMI), as a surrogate of muscle mass (COPDL, n = 10) (FEV1 33 ± 4...
May 3, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28468124/temporal-evolution-of-ultrafine-particles-and-of-alveolar-deposited-surface-area-from-main-indoor-combustion-and-non-combustion-sources-in-a-model-room
#19
Maurizio Manigrasso, Matteo Vitali, Carmela Protano, Pasquale Avino
Aerosol number size distributions, PM mass concentrations, alveolar deposited surface areas (ADSAs) and VOC concentrations were measured in a model room when aerosol was emitted by sources frequently encountered in indoor environments. Both combustion and non-combustion sources were considered. The most intense aerosol emission occurred when combustion sources were active (as high as 4.1×10(7)particlescm(-3) for two meat grilling sessions; the first with exhaust ventilation, the second without). An intense spike generation of nucleation particles occurred when appliances equipped with brush electric motors were operating (as high as 10(6)particlescm(-3) on switching on an electric drill)...
April 29, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28464871/secretion-of-the-endoplasmic-reticulum-stress-protein-grp78-into-the-balf-is-increased-in-cigarette-smokers
#20
Mark O Aksoy, Victor Kim, William D Cornwell, Thomas J Rogers, Beata Kosmider, Karim Bahmed, Carlos Barrero, Salim Merali, Neena Shetty, Steven G Kelsen
BACKGROUND: Identification of biomarkers of cigarette smoke -induced lung damage and early COPD is an area of intense interest. Glucose regulated protein of 78 kD (i.e., GRP78), a multi-functional protein which mediates cell responses to oxidant stress, is increased in the lungs of cigarette smokers and in the serum of subjects with COPD. We have suggested that secretion of GRP78 by lung cells may explain the increase in serum GRP78 in COPD. To assess GRP78 secretion by the lung, we assayed GRP78 in bronchoalveolar lavage fluid (BALF) in chronic smokers and non-smokers...
May 2, 2017: Respiratory Research
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