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Smoking and oxidative stress

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https://www.readbyqxmd.com/read/28925870/pollution-and-sun-exposure-a-deleterious-synergy-mechanisms-and-opportunities-for-skin-protection
#1
Laurent Marrot
Pollutants are highly diverse chemical entities, including gases such as ozone or nitrogen and sulphur oxides and particulate matter of different sizes and with different chemical constituents. PM2.5 is composed of particles that are sometimes about ten nanometres or so in size (ultrafine particles) which can be deposited in lung alveoli, translocated into capillaries and then distributed to all organs through blood circulation. PM2.5 is often associated with toxic chemicals such as heavy metals or polycyclic aromatic hydrocarbons (PAHs) and some photo-reactive PAHs can induce strong oxidative stress under UVA exposure...
September 18, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28923327/vitamin-e-deficiency-and-oxidative-status-are-associated-with-prediabetes-in-apparently-healthy-subjects
#2
Gabriela Rodríguez-Ramírez, Luis E Simental-Mendía, Manuela de la A Carrera-Gracia, Martha-Angélica Quintanar-Escorza
BACKGROUND: Previous studies have indicated that vitamin E deficiency and oxidative stress affect the beta cell function. Hence, the aim of this study was to determine the association between vitamin E deficiency and oxidative status with prediabetes in apparently healthy subjects. METHODS: Apparently healthy men and women aged 18-65 years were enrolled in a case-control study. Individuals with new diagnosis of prediabetes were considered as cases and compared with a control group of individuals with normal glucose tolerance...
April 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28912356/biomarkers-of-disease-can-be-detected-in-mice-as-early-as-4-weeks-after-initiation-of-exposure-to-third-hand-smoke-levels-equivalent-to-those-found-in-homes-of-smokers
#3
Neema Adhami, Yuxin Chen, Manuela Martins-Green
Third-hand smoke (THS) is a newly discovered environmental health hazard that results from accumulation and aging of second-hand smoke (SHS) toxins on surfaces where smoking has occurred. Our objective was to determine whether there is a time-dependent effect of THS exposure on health. Using an in vivo exposure mouse system that mimics exposure of humans to THS, we investigated its effects on biomarkers found in serum, and in liver and brain tissues. Mice were exposed to THS for 1, 2, 4, or 6 months and brain, liver, and serum were collected...
October 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28911970/mesenchymal-stem-cells-alleviate-oxidative-stress-induced-mitochondrial-dysfunction-in-the-airways
#4
Xiang Li, Charalambos Michaeloudes, Yuelin Zhang, Coen H Wiegman, Ian M Adcock, Qizhou Lian, Judith C W Mak, Pankaj K Bhavsar, Kian Fan Chung
BACKGROUND: Oxidative stress-induced mitochondrial dysfunction may contribute to inflammation and remodeling in chronic obstructive pulmonary disease (COPD). Mesenchymal stem cells (MSCs) protect against lung damage in animal models of COPD. It is unknown whether these effects occur through attenuating mitochondrial dysfunction in airway cells. OBJECTIVE: To examine the effect of induced-pluripotent stem cell-derived MSCs (iPSC-MSCs) on oxidative stress-induce mitochondrial dysfunction in human airway smooth muscle cells (ASMCs) in vitro and in mouse lungs in vivo...
September 11, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28911003/personal-exposure-to-fine-particulate-matter-and-benzo-a-pyrene-from-indoor-air-pollution-and-leukocyte-mitochondrial-dna-copy-number-in-rural-china
#5
Jason Y Y Wong, Wei Hu, George S Downward, Wei Jie Seow, Bryan A Bassig, Bu-Tian Ji, Fusheng Wei, Guoping Wu, Jihua Li, Jun He, Chin-San Liu, Wen-Ling Cheng, Yunchao Huang, Kaiyun Yang, Ying Chen, Nathaniel Rothman, Roel C Vermeulen, Qing Lan
Households in Xuanwei and Fuyuan, China, possess hazardous levels of fine particulate matter with an aerodynamic diameter <2.5 microns (PM2.5) and polycyclic aromatic hydrocarbons (PAHs) from coal combustion. Previous studies found that increased exposure to PM2.5 and benzo[a]pyrene (BaP; a PAH) were associated with decreased mitochondrial DNA copy number (mtDNAcn), a marker of oxidative stress. We further evaluated these associations in a cross-sectional study of 148 healthy non-smoking women from Xuanwei and Fuyuan...
September 1, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28904075/association-between-living-in-food-deserts-and-cardiovascular-risk
#6
Heval M Kelli, Muhammad Hammadah, Hina Ahmed, Yi-An Ko, Matthew Topel, Ayman Samman-Tahhan, Mossab Awad, Keyur Patel, Kareem Mohammed, Laurence S Sperling, Priscilla Pemu, Viola Vaccarino, Tene Lewis, Herman Taylor, Greg Martin, Gary H Gibbons, Arshed A Quyyumi
BACKGROUND: Food deserts (FD), neighborhoods defined as low-income areas with low access to healthy food, are a public health concern. We evaluated the impact of living in FD on cardiovascular risk factors and subclinical cardiovascular disease (CVD) with the hypothesis that people living in FD will have an unfavorable CVD risk profile. We further assessed whether the impact of FD on these measures is driven by area income, individual household income, or area access to healthy food. METHODS AND RESULTS: We studied 1421 subjects residing in the Atlanta metropolitan area who participated in the META-Health study (Morehouse and Emory Team up to Eliminate Health Disparities; n=712) and the Predictive Health study (n=709)...
September 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28895883/the-effects-of-resveratrol-on-inflammation-and-oxidative-stress-in-a-rat-model-of-chronic-obstructive-pulmonary-disease
#7
Xiao-Li Wang, Ting Li, Ji-Hong Li, Shu-Ying Miao, Xian-Zhong Xiao
Oxidative stress and inflammation are hypothesized to contribute to the pathogenesis of chronic obstructive pulmonary disease (COPD). Resveratrol (trans-3,5,4'-trihydroxystilbene) is known for its antioxidant and anti-inflammatory properties. The study aimed to investigate the effects of resveratrol in a rat model with COPD on the regulation of oxidative stress and inflammation via the activation of Sirtuin1 (SIRTl) and proliferator-activated receptor-γ coactivator-1α (PGC-1α). Thirty Wistar rats were randomly divided into three groups: control group, COPD group and resveratrol intervention group...
September 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28895641/relationship-between-oxidative-stress-inflammation-and-dyslipidemia-with-fatty-liver-index-in-patients-with-type-2-diabetes-mellitus
#8
Aleksandra Klisic, Aleksandra Isakovic, Gordana Kocic, Nebojsa Kavaric, Milovan Jovanovic, Elvir Zvrko, Verica Skerovic, Ana Ninic
Introduction/Aim Considering the high prevalence of non-alcoholic fatty liver disease (NAFLD) in individuals with type 2 diabetes mellitus (DM2), we aimed to investigate the potential benefit of determining markers of oxidative stress, inflammation and dyslipidemia for prediction of NAFLD, as estimated with fatty liver index (FLI) in individuals with DM2. Methods A total of 139 individuals with DM2 (of them 49.9% females) were enrolled in cross-sectional study. Anthropometric and biochemical parameters, as well as blood pressure were obtained...
September 11, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28895434/genetic-variation-and-risk-of-dna-damage-in-peripheral-blood-lymphocytes-of-iranian-formaldehyde-exposed-workers
#9
Rezvan Zendehdel, Parviz Abdolmaleki, Fatemeh Javani Jouni, Mohammad Mazinani
Formaldehyde (FA) has given positive results for the genetic damage evaluated in human peripheral blood lymphocytes. Polymorphism plays a special role in the toxicity of chemicals. DNA damage in blood cells was evaluated in workers who were occupationally exposed to FA. This study tested the association of alcohol dehydrogenase III (ADH3) and manganese-superoxide dismutase (Mn-SOD) gene polymorphism, with DNA damage of peripheral blood lymphocytes. Gene polymorphisms were evaluated in 54 workers from melamine dinnerware workshops and 34 workers from dairy production workshops...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28881145/secondhand-tobacco-smoke-and-severity-in-wheezing-children-nasal-oxidant-stress-and-inflammation
#10
Ozge Yilmaz, Ahmet Turkeli, Ece Onur, Sema Bilge, Hasan Yuksel
OBJECTIVES: Prenatal and postnatal smoke exposures are associated with many lung diseases in children due to impaired lung function, increased inflammation, and oxidative stress. We aimed to determine the influence of secondhand tobacco smoke exposure on the levels of nasal glutathione, IL-8, IL-17, MMP-9, and TIMP-1, as well as serum surfactant protein-D (SP-D) in wheezy children. METHODS: We enrolled 150 children with recurrent wheezing and recorded wheezing characteristics at enrollment...
September 7, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28868971/mucoadhesive-solid-lipid-microparticles-for-controlled-release-of-a-corticosteroid-in-the-chronic-obstructive-pulmonary-disease-treatment
#11
Erika Amore, Maria Ferraro, Maria Letizia Manca, Mark Gjomarkaj, Gaetano Giammona, Elisabetta Pace, Maria Luisa Bondì
AIM: Therapeutic efficacy of pulmonary diseases is often limited and drug delivery systems offer new solutions to clinical problems. Solid lipid microparticles (SLMs) are suggested as systems for the delivery of therapeutics to the lung as, because of their size, they are able to deposit into secondary bronchi. MATERIALS & METHODS: Here, we describe two novel different SLMs using chitosan and alginate such as mucoadhesive polymers and we also studied their biocompatibility and their effectiveness compared with the free drug in controlling senescence and inflammatory processes in cigarette smoke extracts...
September 4, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28860664/cadmium-induced-er-stress-and-inflammation-are-mediated-through-c-ebp-ddit3-signaling-in-human-bronchial-epithelial-cells
#12
Jeeyoung Kim, Haengseok Song, Hye-Ryeon Heo, Jung Woon Kim, Hye-Ryun Kim, Yoonki Hong, Se-Ran Yang, Seon-Sook Han, Seung-Joon Lee, Woo Jin Kim, Seok-Ho Hong
Cadmium (Cd), a major component of cigarette smoke, disrupts the normal functions of airway cells and can lead to the development of various pulmonary diseases such as chronic obstructive pulmonary disease (COPD). However, the molecular mechanisms involved in Cd-induced pulmonary diseases are poorly understood. Here, we identified a cluster of genes that are altered in response to Cd exposure in human bronchial epithelial cells (BEAS-2B) and demonstrated that Cd-induced ER stress and inflammation are mediated via CCAAT-enhancer-binding proteins (C/EBP)-DNA-damaged-inducible transcript 3 (DDIT3) signaling in BEAS-2B cells...
September 1, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28858636/damage-associated-molecular-pattern-markers-hmgb1-and-cell-free-fetal-telomere-fragments-in-oxidative-stressed-amnion-epithelial-cell-derived-exosomes
#13
Samantha Sheller-Miller, Rheanna Urrabaz-Garza, George Saade, Ramkumar Menon
Term labor in humans is associated with increased oxidative stress (OS) -induced senescence and damages to amnion epithelial cells (AECs). Senescent fetal cells release alarmin high-mobility group box 1 (HMGB1) and cell-free fetal telomere fragments (cffTF) which can be carried by exosomes to other uterine tissues to produce parturition-associated inflammatory changes. This study characterized AEC-derived exosomes under normal and OS conditions and their packaging of HMGB1 and cffTF. Primary AECs were treated with either standard media or oxidative stress-induced media (exposure to cigarette smoke extract for 48h)...
August 24, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28854057/impact-of-commercial-cigarette-smoke-condensate-on-brain-tissue-co-cultured-with-astrocytes-and-blood-brain-barrier-endothelial-cells
#14
Seon-Bong Lee, Ju-Hyeong Kim, Myung-Haing Cho, Eun-Sang Choe, Kwang-Sik Kim, Soon-Mi Shim
The purpose of the current study was to investigate the effect of two commercial cigarette smoke condensates (CCSC) on oxidative stress and cell cytotoxicity in human brain (T98G) or astrocytes (U-373 MG) in the presence of human brain microvascular endothelial cells (HBMEC). Cell viability of mono-culture of T98G or U-373 MG was markedly decreased in a concentration-dependent manner, and T98G was more susceptible than U-373 MG to CCSC exposure. Cytotoxicity was less prominent when T98G was co-cultured with HBMEC than when T98G was co-cultured with U-373 MG...
August 30, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28845530/association-between-the-antioxidant-uric-acid-and-depression-and-antidepressant-medication-use-in-96-989-individuals
#15
M K Wium-Andersen, C J Kobylecki, S Afzal, B G Nordestgaard
OBJECTIVE: In the last decade, several studies have suggested that depression is accompanied by increased oxidative stress and decreased antioxidant defenses. We tested the hypothesis that high levels of the antioxidant uric acid are associated with lower risk of hospitalization with depression and use of prescription antidepressant medication. METHOD: We examined plasma levels of the antioxidant uric acid in 96 989 individuals from two independent cohort studies...
August 28, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28837637/gstm1-gstt1-double-null-genotype-increases-risk-of-treatment-resistant-schizophrenia-a-genetic-association-study-in-brazilian-patients
#16
Denise S Pinheiro, Rodrigo da S Santos, Rodrigo B de Brito, Aline Helena da S Cruz, Paulo C Ghedini, Angela A S Reis
BACKGROUND: The role of oxidative stress in schizophrenia has been demonstrated, particularly in subjects with treatment-resistant schizophrenia (TRS). In such patients, the decreased levels of antioxidants in conjunction with the increased generation of reactive oxygen species in the brain exposes the neurons to a higher risk of damage. METHODS AND FINDINGS: We evaluated the association of deletion polymorphisms of two genes of the antioxidant Glutathione S-Transferase family, GSTT1 and GSTM1, with susceptibility to TRS...
2017: PloS One
https://www.readbyqxmd.com/read/28837515/dietary-polyphenols-in-the-aetiology-of-crohn-s-disease-and-ulcerative-colitis-a-multicenter-european-prospective-cohort-study-epic
#17
Yunxia Lu, Raul Zamora-Ros, Simon Chan, Amanda J Cross, Heather Ward, Paula Jakszyn, Robert Luben, Jorrit L Opstelten, Bas Oldenburg, Göran Hallmans, Pontus Karling, Olof Grip, Timothy Key, Manuela M Bergmann, Heiner Boeing, Kim Overvad, Domenico Palli, Giovanna Masala, Kay-Tee Khaw, Antoine Racine, Franck Carbonnel, Marie-Christine Boutron-Ruault, Vibeke Andersen, Anja Olsen, Anne Tjonneland, Rudolf Kaaks, Rosario Tumino, Antonia Trichopoulou, Augustin Scalbert, Elio Riboli, Andrew R Hart
BACKGROUND: Oxidative stress may be involved in the aetiology of inflammatory bowel disease and whether dietary polyphenols, which possess antioxidants properties, prevent its development is unknown. METHODS: A total of 401,326 men and women aged 20 to 80 years from 8 countries were recruited between 1991 and 1998 and at baseline completed validated food frequency questionnaires. Dietary polyphenol intake was measured using Phenol-Explorer, a database with information on the content of 502 polyphenols...
August 22, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28828972/endothelium-and-oxidative-stress-the-pandora-s-box-of-cerebral-and-non-only-small-vessel-disease
#18
M Maccarrone, L Ulivi, N Giannini, V Montano, L Ghiadoni, R M Bruno, U Bonuccelli, M Mancuso
Common cerebral small vessel disease (cSVD) abnormalities are a common neuroradiological finding, especially in the elderly. They are associated with a wide clinical spectrum that leads to an increasing disability, impaired global function outcome and a reduced quality of life. A strong association is demonstrated with age and hypertension and other common vascular risk factors, including diabetes mellitus, dyslipoproteinemia, smoking, low vitamin B12 level, and hyperomocysteinemia. Although these epidemiological associations suggest a systemic involvement, etiopathogenetic mechanisms remain unclear...
August 21, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/28826667/ecology-of-the-cardiovascular-system-a-focus-on-air-related-environmental-factors
#19
REVIEW
Jean François Argacha, T Bourdrel, P van de Borne
Cardiology is a newcomer to environmental sciences. We aim to propose an original review of the scientific evidence regarding the effects of the environment on cardiovascular health. We report first influences of air-related environmental factors. Air temperature has a strong influence on cardiovascular mortality characterized by a V-like relationship confirming that both cold and hot periods have negative cardiovascular impacts. Furthermore, dynamic changes in temperature are likely more important than the absolute air temperature level...
August 4, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28818596/cardiometabolic-phenotypes-and-mitochondrial-dna-copy-number-in-two-cohorts-of-uk-women
#20
Anna L Guyatt, Kimberley Burrows, Philip A I Guthrie, Sue Ring, Wendy McArdle, Ian N M Day, Raimondo Ascione, Debbie A Lawlor, Tom R Gaunt, Santiago Rodriguez
The mitochondrial genome is present at variable copy number between individuals. Mitochondria are vulnerable to oxidative stress, and their dysfunction may be associated with cardiovascular disease. The association of mitochondrial DNA copy number with cardiometabolic risk factors (lipids, glycaemic traits, inflammatory markers, anthropometry and blood pressure) was assessed in two independent cohorts of European origin women, one in whom outcomes were measured at mean (SD) age 30 (4.3) years (N=2278) and the second at 69...
August 15, 2017: Mitochondrion
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