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Smoking and oxidative stress

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https://www.readbyqxmd.com/read/28646795/offsetting-the-impact-of-smoking-and-e-cigarette-vaping-on-the-cerebrovascular-system-and-stroke-injury-is-metformin-a-viable-countermeasure
#1
Mohammad A Kaisar, Heidi Villalba, Shikha Prasad, Taylor Liles, Ali Ehsan Sifat, Ravi K Sajja, Thomas J Abbruscato, Luca Cucullo
Recently published in vitro and in vivo findings strongly suggest that BBB impairment and increased risk for stroke by tobacco smoke (TS) closely resemble that of type-2 diabetes (2DM) and develop largely in response to common key modulators such oxidative stress (OS), inflammation and alterations of the endogenous antioxidative response system (ARE) regulated by the nuclear factor erythroid 2-related factor (Nrf2). Preclinical studies have also shown that nicotine (the principal e-liquid's ingredient used in e-cigarettes) can also cause OS, exacerbation of cerebral ischemia and secondary brain injury...
June 17, 2017: Redox Biology
https://www.readbyqxmd.com/read/28641491/nicotine-and-cigarette-smoke-modulate-nrf2-bdnf-dopaminergic-signal-and-neurobehavioral-disorders-in-adult-rat-cerebral-cortex
#2
Nibedita Naha, D N Gandhi, A K Gautam, J Ravi Prakash
BACKGROUND: Nicotine and cigarette smoking (CS) are associated with addiction behavior, drug-seeking, and abuse. However, the mechanisms that mediate this association especially, the role of brain-derived neurotrophic factor (BDNF), dopamine (DA), and nuclear factor erythroid 2-related factor 2 (Nrf2) signaling in the cerebral cortex, are not fully known. Therefore, we hypothesized that overexpression of BDNF and DA, and suppression of Nrf2 contribute to several pathological and behavioral alterations in adult cerebral cortex...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28639572/relation-of-biochemical-parameters-with-flow-mediated-dilatation-in-patients-with-metabolic-syndrome
#3
Nurver Turfaner Sipahioglu, Barıs Ilerigelen, Zeynep B Gungor, Gulsel Ayaz, Hakan Ekmekci, Cigdem Bayram Gurel, Gunay Can, Huseyin Sonmez, Turgut Ulutin, Fikret Sipahioglu
BACKGROUND: Metabolic syndrome (MetS) is one of the high cardiovascular (CV) situations. Endothelial dysfunction, which is a common finding in patients with MetS, is related with increased CV risk. In patients with MetS, the effect of the major CV risk factors, not included in the MetS definition, on endothelial dysfunction is not well known. The aim of this study was to determine the effect of major CV risk factors such as gender, smoking, family history, and biochemical parameters on endothelial dysfunction in patients with MetS...
July 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28637174/effect-of-prenatal-exposure-to-waterpipe-tobacco-smoke-on-learning-and-memory-of-adult-offspring-rats
#4
Nour Al-Sawalha, Karem Alzoubi, Omar Khabour, Weam Alyacoub, Yehya Almahmmod, Thomas Eissenberg
Introduction: Waterpipe tobacco smoking has increased in prevalence worldwide, including among pregnant women. In this study, we investigated the effect of prenatal maternal waterpipe tobacco smoke (WTS) exposure during different stages of pregnancy on learning and memory of adult offspring rats. Methods: Pregnant rats received either fresh air or mainstream WTS (two hours daily) during early, mid, late, or whole gestational period. Male offspring rats were followed through 20 weeks...
June 20, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28635583/cigarette-smoke-is-associated-with-altered-expression-of-antioxidant-enzymes-in-granulosa-cells-from-women-undergoing-in-vitro-fertilization
#5
Maria Cristina Budani, Erminia Carletti, Gian Mario Tiboni
This study was undertaken to evaluate whether cigarette smoke is associated with changes in the expression of antioxidant enzymes in granulosa cells of women undergoing IVF treatments. For this aim, the expression of three antioxidant enzymes (SOD1, SOD2 and catalase) in non-smokers (n = 20) and smokers (n = 20) was analyzed. There was a statistically significant overexpression of SOD2 and catalase mRNA levels in smokers in comparison with non-smokers. Cigarette smoking was associated with a lower fertilization rate, implantation rate and pregnancy rate in comparison with non-smokers...
June 21, 2017: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/28631934/breast-milk-from-smokers-contains-less-cholesterol-and-protein-and-smaller-size-of-apolipoprotein-a-i-resulting-in-lower-zebrafish-embryo-survivability
#6
Seong-Min Kim, Suk-Jeong Kim, Jae-Yong Kim, Jae-Ryong Kim, Kyung-Hyun Cho
BACKGROUND: To determine the quality of breast milk (BM), we compared the functions of BM from ex-smokers and nonsmokers. SUBJECTS AND METHODS: We analyzed the contents of lipids, glucose, and protein in BM from ex-smokers (10 cigarettes/day for 13 ± 3 years) as well as infant formula. RESULTS: Nonsmokers' BM showed 2.4- and 1.4-fold higher cholesterol and protein contents, respectively, than BM from smokers. Infant formula contained almost no cholesterol, but did show remarkably higher glucose and triglyceride levels than BM...
June 20, 2017: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/28629367/african-american-esophageal-squamous-cell-carcinoma-expression-profile-reveals-dysregulation-of-stress-response-and-detox-networks
#7
Hayriye Verda Erkizan, Kory Johnson, Svetlana Ghimbovschi, Deepa Karkera, Gregory Trachiotis, Houtan Adib, Eric P Hoffman, Robert G Wadleigh
BACKGROUND: Esophageal carcinoma is the third most common gastrointestinal malignancy worldwide and is largely unresponsive to therapy. African-Americans have an increased risk for esophageal squamous cell carcinoma (ESCC), the subtype that shows marked variation in geographic frequency. The molecular architecture of African-American ESCC is still poorly understood. It is unclear why African-American ESCC is more aggressive and the survival rate in these patients is worse than those of other ethnic groups...
June 19, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28606749/cardiovascular-disease-in-systemic-lupus-erythematosus-a-comprehensive-update
#8
REVIEW
Mayra Giannelou, Clio P Mavragani
Heightened rates of both cardiovascular (CV) events and subclinical atherosclerosis, documented by imaging and vascular function techniques are well established in systemic lupus erythematosus (SLE). While traditional CV factors such as smoking, dyslipidemia, diabetes mellitus (DM), hypertension, central obesity and hyperhomocysteinemia have been reported to be prevalent in lupus patients, they do not fully explain the high rates of ischemic events so far reported, implying that other factors inherent to disease itself could account for the enhanced risk, including disease duration, activity and chronicity, psychosocial factors, medications, genetic variants and altered immunological mechanisms...
June 9, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28606272/-progression-of-the-pathogenesis-of-thyroid-associated-ophthalmopathy
#9
L Wang, J M Ma
Thyroid associated ophthalmopathy (TAO) is a common complication of Graves' disease (GD). The clinical manifestations are mainly swelling and retracted eyelid, protopsis and limited eye movements, and optic neuropathy can be seen in severe cases. The mechanism of TAO is not yet clear. A large number of studies have found that the disorders of autoimmunity play an important role in TAO, while genetic factors, oxidative stress, and environmental factors such as smoking participate in it. Therefore, we consult a large number of studies and expound the pathogenesis from the aspects of genetic susceptibility, immune mechanism, oxidative stress, and the effects of smoking to provide referrences for clinical associated studies...
June 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28605262/chronic-obstructive-pulmonary-disease-from-injury-to-genomic-stability
#10
Luiz Philippe da Silva Sergio, Flavia de Paoli, Andre Luiz Mencalha, Adenilson de Souza da Fonseca
Chronic obstructive pulmonary disease (COPD) is the fourth cause of death in the world and it is currently presenting a major global public health challenge, causing premature death from pathophysiological complications and rising economic and social burdens. COPD develops from a combination of factors following exposure to pollutants and cigarette smoke, presenting a combination of both emphysema and chronic obstructive bronchitis, which causes lung airflow limitations that are not fully reversible by bronchodilators...
June 12, 2017: COPD
https://www.readbyqxmd.com/read/28604836/elevated-sodium-leads-to-the-increased-expression-of-hsp60-and-induces-apoptosis-in-huvecs
#11
Bojana Jakic, Maja Buszko, Giuseppe Cappellano, Georg Wick
Atherosclerosis is the leading cause of death in the world. We have previously shown that expression of heat shock protein 60 (HSP60) on the surface of endothelial cells is the main cause of initiating the disease as it acts as a T cell auto-antigen and can be triggered by classical atherosclerosis risk factors, such as infection (e.g. Chlamydia pneumoniae), chemical stress (smoking, oxygen radicals, drugs), physical insult (heat, shear blood flow) and inflammation (inflammatory cytokines, lipopolysaccharide, oxidized low density lipoprotein, advanced glycation end products)...
2017: PloS One
https://www.readbyqxmd.com/read/28599285/association-between-single-nucleotide-polymorphisms-in-the-antioxidant-genes-cat-gr-and-sod1-erythrocyte-enzyme-activities-dietary-and-life-style-factors-and-breast-cancer-risk-in-a-danish-prospective-cohort-study
#12
Tine Iskov Kopp, Ulla Vogel, Lars Ove Dragsted, Anne Tjonneland, Gitte Ravn-Haren
Exposure to estrogens and alcohol consumption - the two only well-established risk factors for breast cancer - are capable of causing oxidative stress, which has been linked to progression of breast cancer. Here, five functional polymorphisms in the antioxidant genes SOD1, CAT and GSR were investigated in 703 breast cancer case-control pairs in the Danish, prospective "Diet, Cancer and Health" cohort together with gene-environment interactions between the polymorphisms, enzyme activities and intake of fruits and vegetables, alcohol and smoking in relation to breast cancer risk...
May 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28595930/a-novel-hybrid-product-that-heats-tobacco-through-controlled-aerosol-release-part-2-in%C3%A2-vitro-biological-assessment-and-comparison-with-different-tobacco-heating-products
#13
Damien Breheny, Jason Adamson, David Azzopardi, Andrew Baxter, Emma Bishop, Tony Carr, Ian Crooks, Katherine Hewitt, Tomasz Jaunky, Sophie Larard, Frazer Lowe, Oluwatobiloba Oke, Mark Taylor, Simone Santopietro, David Thorne, Benjamin Zainuddin, Marianna Gaça, Chuan Liu, James Murphy, Christopher Proctor
This study assessed the toxicological and biological responses of aerosols from a novel hybrid tobacco product. Toxicological responses from the hybrid tobacco product were compared to those from a commercially available Tobacco Heating Product (c-THP), a prototype THP (p-THP) and a 3R4F reference cigarette, using in vitro test methods which were outlined as part of a framework to substantiate the risk reduction potential of novel tobacco and nicotine products. Exposure matrices used included total particulate matter (TPM), whole aerosol (WA), and aqueous aerosol extracts (AqE) obtained after machine-puffing the test products under the Health Canada Intense smoking regime...
May 30, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28595325/maternal-lifetime-stress-and-prenatal-psychological-functioning-are-associated-with-decreased-placental-mitochondrial-dna-copy-number-in-the-prism-study
#14
Kelly J Brunst, Marco Sanchez Guerra, Chris Gennings, Michele Hacker, Calvin Jara, Michelle Bosquet Enlow, Robert O Wright, Andrea Baccarelli, Rosalind J Wright
Psychosocial stress contributes to placental oxidative stress. Mitochondria are vulnerable to oxidative stress which can lead to changes in mitochondrial DNA copy number (mtDNAcn). We examined associations between maternal lifetime stress, current negative life events, depressive and posttraumatic stress disorder symptom scores and placental mtDNAcn in a racially/ethnically diverse sample (N = 147) from the PRogramming of Intergenerational Stress Mechanisms study (March 2011- August 2012). In linear regression analyses adjusted for maternal age, race/ethnicity, education, prenatal fine particulate matter, prenatal smoking, and child sex, all measures of stress were associated with decreased placental mtDNAcn (all P-values < 0...
June 8, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28588027/exogenous-neutrophil-elastase-enters-bronchial-epithelial-cells-and-suppresses-cigarette-smoke-extract-induced-heme-oxygenase-1-by-cleaving-sirtuin-1
#15
Kyoung-Hee Lee, Jiyeong Jeong, Yoon-Jung Koo, An-Hee Jang, Chang-Hoon Lee, Chul-Gyu Yoo
An imbalance between oxidative stress and antioxidant activity plays an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Cigarette smoke, a major risk factor of COPD, induces cellular oxidative stress, but levels of antioxidants such as heme oxygenase-1 (HO-1) are reduced in individuals with severe COPD. In this study, we evaluated the molecular mechanism of reduced HO-1 expression in human bronchial epithelial cells. We found that cigarette smoke extract (CSE) increases HO-1 levels via activation of NFE2-related factor 2 (Nrf2)...
June 6, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28577950/association-of-mth1-expression-with-the-tumor-malignant-potential-and-poor-prognosis-in-patients-with-resected-lung-cancer
#16
Takatoshi Fujishita, Tatsuro Okamoto, Takaki Akamine, Shinkichi Takamori, Kazuki Takada, Masakazu Katsura, Goji Toyokawa, Fumihiro Shoji, Mototsugu Shimokawa, Yoshinao Oda, Yusaku Nakabeppu, Yoshihiko Maehara
OBJECTIVES: The oxidized purine nucleoside triphosphatase, mutT homolog 1 (MTH1), physiologically sanitizes 8-oxo-dGTP in the nucleotide pool. Previous studies indicated that MTH1 is associated with tumor proliferation and invasion in non-small cell lung cancer (NSCLC) cell lines; however, the role of MTH1 in patients with NSCLC remains unclear. MATERIALS AND METHODS: Two patient cohorts that underwent surgery for NSCLC in our institution were investigated retrospectively...
July 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28577134/role-of-oxidative-stress-in-the-suppression-of-immune-responses-in-peripheral-blood-mononuclear-cells-exposed-to-combustible-tobacco-product-preparation
#17
Subhashini Arimilli, Eckhardt Schmidt, Brad E Damratoski, G L Prasad
Cigarette smoking is a major risk factor for several human diseases. Chronic inflammation, resulting from increased oxidative stress, has been suggested as a mechanism that contributes to the increased susceptibility of smokers to cancer and microbial infections. We have previously shown that whole-smoke conditioned medium (WS-CM) and total particulate matter (TPM) prepared from Kentucky 3R4F reference cigarettes [collectively called as combustible tobacco product preparations (TPPs)] potently suppressed agonist-stimulated cytokine secretion and target cell killing in peripheral blood mononuclear cells (PBMCs)...
June 2, 2017: Inflammation
https://www.readbyqxmd.com/read/28572698/phosphorylation-of-histone-h2a-x-in-peripheral-blood-mononuclear-cells-may-be-a-useful-marker-for-monitoring-cardiometabolic-risk-in-nondiabetic-individuals
#18
So Ra Yoon, Juhyun Song, Jong Hwa Lee, Oh Yoen Kim
Phosphorylation of H2A.X (serine 139) in the histone H2A family located in the downstream of the DNA damage kinase signaling cascade is an important indicator of DNA damage. Recently, phosphorylation of H2A.X was proposed as a sensitive biomarker of aging. This study investigated if phosphorylation of H2A.X in peripheral blood mononuclear cells (PBMCs) is associated with cardiometabolic risk in nondiabetic individuals. Basic parameters and oxidative stress/inflammatory markers were measured in nondiabetic healthy Koreans (n = 119)...
2017: Disease Markers
https://www.readbyqxmd.com/read/28566717/metabolomic-profiling-in-a-hedgehog-interacting-protein-hhip-murine-model-of-chronic-obstructive-pulmonary-disease
#19
Emily S Wan, Yan Li, Taotao Lao, Weiliang Qiu, Zhiqiang Jiang, John D Mancini, Caroline A Owen, Clary Clish, Dawn L DeMeo, Edwin K Silverman, Xiaobo Zhou
Genetic variants annotated to the hedgehog interacting protein (HHIP) are robustly associated with chronic obstructive pulmonary disease (COPD). Hhip haploinsufficiency in mice leads to increased susceptibility towards the development of emphysema following exposure to chronic cigarette smoke (CS). To explore the molecular pathways which contribute to increased susceptibility, we performed metabolomic profiling using high performance liquid chromatography tandem mass spectroscopy (LC/MS-MS) on plasma, urine, and lung tissue of Hhip (+/-) heterozygotes and wild type (Hhip (+/+)) C57/BL6 mice exposed to either room-air or CS for six months...
May 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28564628/severity-of-anxiety-but-not-depression-is-associated-with-oxidative-stress-in-major-depressive-disorder
#20
Lisa R Steenkamp, Christina M Hough, Victor I Reus, Felipe A Jain, Elissa S Epel, S Jill James, Alexandra E Morford, Synthia H Mellon, Owen M Wolkowitz, Daniel Lindqvist
BACKGROUND: Oxidative stress is implicated in both depression and anxiety, but it is currently unclear whether this relates to syndromal diagnoses or trans-diagnostic dimensional symptoms. We examined the relationship between oxidative stress and severity of depression and anxiety symptoms in individuals with Major Depressive Disorder (MDD). METHODS: Plasma oxidative stress markers F2-isoprostanes and oxidized glutathione (GSSG), and the antioxidant reduced glutathione (GSH), were assessed in 69 physically healthy, medication-free MDD subjects...
September 2017: Journal of Affective Disorders
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