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Smoking and oxidative stress

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https://www.readbyqxmd.com/read/29782855/role-of-statins-and-mevalonate-pathway-on-impaired-hdac2-activity-induced-by-oxidative-stress-in-human-airway-epithelial-cells
#1
Maria Gabriella Matera, Luigino Calzetta, Giulia Gritti, Laura Gallo, Brunella Perfetto, Giovanna Donnarumma, Mario Cazzola, Paola Rogliani, Maria Donniacuo, Barbara Rinaldi
In patients with chronic obstructive pulmonary disease (COPD) the inflammatory response is often steroid-resistant, likely since oxidative stress and cigarette smoking impair histone deacetylase 2 (HDAC2) activity. Since it has been demonstrated that statins may restore the HDAC2 activity in cultured human endothelial cells, the aim of this study was to investigate the effects of statins in reversing the steroid-resistance induced by oxidative stress. We evaluated the effects of simvastatin and dexamethasone on HDAC2 expression and activity, and the role of mevalonate and Rho/ROCK pathways in A549 cells, a human lung type II epithelial cell line stressed with H2 O2 ...
May 18, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29781747/sialylation-pattern-in-lung-epithelial-cell-line-and-siglecs-expression-in-monocytic-thp-1-cells-as-cellular-indicators-of-cigarette-smoke-induced-pathology-in-vitro
#2
Przemyslaw Wielgat, Emil Trofimiuk, Robert Czarnomysy, Adam Holownia, Jan J Braszko
PURPOSE: Cellular response to cigarette smoke (CS) involves activation of recognition receptors resulting in changes in immune status, oxidative stress and cell turnover. We investigated the effects of CS on sialic acid-binding immunoglobulin type lectins (Siglecs) expression and their sialylated ligands in human immune and non-immune cells. METHODS: Human monocytes (THP-1) and epithelial cells (A549) were cultured in CS-conditioned medium (CSM). Expression of Siglec-8 and Siglec-5/Siglec-14 was analysed in THP-1 cells using flow cytometry...
May 21, 2018: Experimental Lung Research
https://www.readbyqxmd.com/read/29778463/urinary-8-isoprostane-levels-and-occurrence-of-lung-colorectal-prostate-breast-and-overall-cancer-results-from-a-large-population-based-cohort-study-with-14-years-of-follow-up
#3
Xīn Gào, Hermann Brenner, Bernd Holleczek, Katarina Cuk, Yan Zhang, Ankita Anusruti, Yang Xuan, Yiwei Xu, Ben Schöttker
BACKGROUND: Urinary 8-isoprostane is an established biomarker for lipid peroxidation. However, the association between its pre-diagnostic levels and cancer incidence has rarely been evaluated. METHODS: 8,793 older adults from the German ESTHER cohort were followed up for cancer incidence by cancer registry data. A directed acyclic graph was utilized to identify potential confounders. Multivariate Cox regression models were applied to estimate hazard ratios (HRs) and 95% confidence intervals (95% CI)...
May 17, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29765317/sodium-tanshinone-iia-sulfonate-decreases-cigarette-smoke-induced-inflammation-and-oxidative-stress-via-blocking-the-activation-of-mapk-hif-1%C3%AE-signaling-pathway
#4
Ruijuan Guan, Jian Wang, Ziying Li, Mingjing Ding, Defu Li, Guihua Xu, Tao Wang, Yuqin Chen, Qian Yang, Zhen Long, Zhou Cai, Chenting Zhang, Xue Liang, Lian Dong, Li Zhao, Haiyun Zhang, Dejun Sun, Wenju Lu
Aberrant activation of hypoxia-inducible factor (HIF)-1α is frequently encountered and promotes oxidative stress and inflammation in chronic obstructive pulmonary disease (COPD). The present study investigated whether sodium tanshinone IIA sulfonate (STS), a water-soluble derivative of tanshinone IIA, can mediate its effect through inhibiting HIF-1α-induced oxidative stress and inflammation in cigarette smoke (CS)-induced COPD in mice. Here, we found that STS improved pulmonary function, ameliorated emphysema and decreased the infiltration of inflammatory cells in the lungs of CS-exposed mice...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29765212/the-effect-of-conjugated-linoleic-acid-on-oxidative-stress-and-matrix-metalloproteinases-2-and-9-in-patients-with-copd
#5
Somaieh Matin, Ali Nemati, Hassan Ghobadi, Reza Alipanah-Moghadam, Lotfollah Rezagholizadeh
Background: Natural antioxidants in foods may be used in prevention and treatment of oxidative stress and inflammation in COPD. Therefore, this study aimed to evaluate the effect of conjugated linoleic acid (CLA) supplement as natural antioxidants on oxidative stress levels, and MMP2 and MMP9 serum levels in COPD patients. Materials and methods: This clinical trial study was conducted on 90 (supplement group=45 and control group=45) COPD patients in Ardabil city, Iran, in 2015...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29762849/effects-of-smoking-on-thiol-disulfide-homeostasis
#6
I Solak, C D Cetinkaya, Y T Gederet, B Kozanhan, O Erel, M A Eryilmaz
OBJECTIVE: Cigarette smoking is an important risk factor for many diseases. This study aimed to evaluate whether cigarette smoking is associated with changes in the thiol/disulfide homeostasis (TDH), a novel biomarker of systemic oxidative stress. PATIENTS AND METHODS: Eighty-four smokers and 86 non-smoking healthy volunteers were enrolled. Serum native thiol, disulfide and total thiol levels, disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol ratios were analyzed using a new colorimetric method...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29757573/low-serum-melatonin-levels-are-associated-with-erectile-dysfunction
#7
Aliseydi Bozkurt, Mehmet Karabakan, Binhan Kagan Aktas, Murat Gunay, Ercüment Keskin, Erkan Hirik
OBJECTIVE: Melatonin is a hormone secreted from the pineal gland and has anti-oxidative and anti-inflammatory effects. Oxidative stress is considered as an important factor in the etiology of erectile dysfunction (ED), and in many experimental models, positive results have been obtained with melatonin treatment. This study aimed to measure serum melatonin levels in ED patients and to investigate the possible relationship between ED and melatonin levels. MATERIALS AND METHODS: Sixty-two patients diagnosed with mild, moderate or severe ED according to the five-item International Erectile Function Index (IIEF-5) and 22 healthy individuals were included in the study...
April 30, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29753146/exposure-to-acrylamide-and-the-risk-of-cardiovascular-diseases-in-the-national-health-and-nutrition-examination-survey-2003-2006
#8
Yu Zhang, Mengmeng Huang, Pan Zhuang, Jingjing Jiao, Xinyu Chen, Jun Wang, Yongning Wu
BACKGROUND: Long-term exposure to acrylamide (AA) from diet sources may induce oxidative stress and chronic inflammation. However, the association between AA exposure and the prevalence of cardiovascular diseases (CVD) remains unclear. OBJECTIVES: We aimed to examine the association between blood exposure levels of AA biomarkers and the prevalence of main types of CVD in a general population of US adults. METHODS: We analyzed the associations between AA hemoglobin biomarkers [hemoglobin adducts of acrylamide (HbAA) and glycidamide (HbGA), sum of HbAA and HbGA (HbAA+HbGA), and ratio of HbGA to HbAA (HbGA:HbAA)] and self-reported diagnosis of CVD in 8290 adults (≥20 years of age) from the National Health and Nutrition Examination Survey (NHANES) 2003-2006...
May 9, 2018: Environment International
https://www.readbyqxmd.com/read/29750543/a-disintegrin-and-a-metalloproteinase-domain-8-adam8-a-novel-protective-proteinase-in-copd
#9
Francesca Polverino, Joselyn Rojas-Quintero, Xiaoyun Wang, Hans Petersen, Li Zhang, Xiaoyan Gai, Andrew Higham, Duo Zhang, Kushagra Gupta, Amit Rout, Ilyas Yambayev, Victor Pinto-Plata, Lynette M Sholl, Danen Cunoosamy, Bartolomé R Celli, James Goldring, Dave Singh, Yohannes Tesfaigzi, Jadwiga Wedzicha, Henric Olsson, Caroline A Owen
RATIONALE: A disintegrin and metalloproteinase-8 (ADAM8) is expressed by leukocytes and epithelial cells in health, but its contribution to the pathogenesis of COPD is unknown. OBJECTIVES: ADAM8 levels were measured in lung, sputum, plasma, and/or bronchoalveolar lavage fluid (BALF) samples from COPD patients, smokers, and non-smokers, and wild-type (WT) mice exposed to cigarette smoke (CS) versus air. COPD-like lung pathologies were compared in CS-exposed WT versus Adam8-/- mice...
May 11, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29740339/induction-of-metallothionein-expression-after-exposure-to-conventional-cigarette-smoke-but-not-electronic-cigarette-ecig-generated-aerosol-in-caenorhabditis-elegans
#10
Eric Cobb, Julie Hall, Dominic L Palazzolo
Aim: With the invention of electronic cigarettes (ECIG), many questions have been raised regarding their safety as an alternative to smoking conventional cigarettes. Conventional cigarette smoke contains a variety of toxicants including heavy metals. However, ECIG-generated aerosol contains only trace amounts of metals, adding to the argument for it being a safer alternative. In response to heavy metal exposure, metallothioneins are induced in cells to help store the metal, detoxify the body, and are also known responders to oxidative stress...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29731655/immune-regulating-effects-of-exercise-on-cigarette-smoke-induced-inflammation
#11
REVIEW
Ashkan Madani, Katharina Alack, Manuel Jonas Richter, Karsten Krüger
Long-term cigarette smoking (LTCS) represents an important risk factor for cardiac infarction and stroke and the central risk factor for the development of a bronchial carcinoma, smoking-associated interstitial lung fibrosis, and chronic obstructive pulmonary disease. The pathophysiologic development of these diseases is suggested to be promoted by chronic and progressive inflammation. Cigarette smoking induces repetitive inflammatory insults followed by a chronic and progressive activation of the immune system...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/29729478/sources-of-free-radicals-and-oxidative-stress-in-the-oral-cavity
#12
REVIEW
Piotr Żukowski, Mateusz Maciejczyk, Danuta Waszkiel
OBJECTIVE: An oral cavity is a place especially susceptible to oxidative damage. It is subjected to many environmental pro-oxidative factors or factors that have the ability to generate reactive oxygen species (ROS). The aim of this article is to present the main sources of ROS and oxidative stress in the oral environment. DESIGN: A literature search was performed using the PubMed and Google Scholar databases. RESULTS: One of the most important ROS sources in the oral cavity is periodontal inflammation...
May 1, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29726912/relationship-of-the-oxidative-damage-biomarker-8-epi-prostaglandin-f2%C3%AE-to-risk-of-lung-cancer-development-in-the-shanghai-cohort-study
#13
Jian-Min Yuan, Steven G Carmella, Renwei Wang, Yu-Ting Tan, Jennifer Adams-Haduch, Yu-Tang Gao, Stephen S Hecht
It has been hypothesized that the pathogenesis of lung cancer induced by cigarette smoking involves oxidative damage by free radicals. Epidemiological data on biomarkers of oxidative damage and risk of lung cancer development are sparse. A nested case-control study of 610 lung cancer cases and 610 matched controls was conducted within a prospective cohort of 18,244 Chinese men in Shanghai, China. The concentrations of 8-epi-prostaglandin F2α (8-epiPGF2α), a biomarker of oxidative stress, were determined in baseline urine samples using a validated mass-spectrometry assay...
May 3, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29726624/regulation-of-eclipta-prostrata-l-components-on-cigarette-smoking-induced-autophagy-of-bronchial-epithelial-cells-via-keap1-nrf2-pathway
#14
Shumin Ding, Xuefeng Hou, Fujing Wang, Gang Wang, Xiaobin Tan, Ying Liu, Yuanli Zhou, Huihui Qiu, E Sun, Nan Jiang, Zihao Li, Jie Song, Liang Feng, Xiaobin Jia
Cigarette smoking extract (CSE)-induced autophagic injury has been regarded as an important contributor to the pathogenesis of lung cancer. We previously found that Eclipta prostrata L. component (CCE) reduced CSE-induced bronchial epithelial cells damage. However, the mechanism remains unknown. Human normal bronchial epithelial cells (NHBE) were exposed to CSE to establish stress model. Nrf2-siRNA and Keap1-siRNA transfection were performed. mRFP-GFP-LC3 dual fluorescence and transmission electron microscopy were used to observe the autophagic characteristics...
May 4, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29724254/radical-containing-combustion-derived-particulate-matter-enhance-pulmonary-th17-inflammation-via-the-aryl-hydrocarbon-receptor
#15
Sridhar Jaligama, Vivek S Patel, Pingli Wang, Asmaa Sallam, Jeffrey Harding, Matthew Kelley, Skylar R Mancuso, Tammy R Dugas, Stephania A Cormier
BACKGROUND: Pollutant particles containing environmentally persistent free radicals (EPFRs) are formed during many combustion processes (e.g. thermal remediation of hazardous wastes, diesel/gasoline combustion, wood smoke, cigarette smoke, etc.). Our previous studies demonstrated that acute exposure to EPFRs results in dendritic cell maturation and Th17-biased pulmonary immune responses. Further, in a mouse model of asthma, these responses were enhanced suggesting exposure to EPFRs as a risk factor for the development and/or exacerbation of asthma...
May 3, 2018: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29724134/cigarette-smoking-and-the-pathogenesis-of-systemic-lupus-erythematosus
#16
Cameron B Speyer, Karen H Costenbader
Systemic lupus erythematosus (SLE) is a multi-system inflammatory autoimmune disease of incompletely understood etiology. It is thought that environmental exposures "trigger" or accelerate the disease in genetically-predisposed individuals. Areas covered: Substantial epidemiological evidence exists to support the association between cigarette smoking and the risk of incident SLE. Recent evidence points to current smoking as the specific risk factor, with decreasing risk 5 years after smoking cessation, and the greatest risk for disease characterized by the presence of SLE- specific autoantibodies...
May 3, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29701955/influence-of-smoking-puff-parameters-and-tobacco-varieties-on-free-radicals-yields-in-cigarette-mainstream-smoke
#17
Reema Goel, Zachary T Bitzer, Samantha M Reilly, Jonathan Foulds, Joshua Muscat, Ryan J Elias, John P Richie
Cigarette smoke is a major exogenous source of free radicals, and the resulting oxidative stress is one of the major causes of smoking-caused diseases. Yet, many of the factors that impact free radical delivery from cigarettes remain unclear. In this study, we machine-smoked cigarettes and measured the levels of gas- and particulate-phase radicals by electron paramagnetic resonance (EPR) spectroscopy using standardized smoking regimens (International Organization of Standardization (ISO) and Canadian Intense (CI)), puffing parameters and tobacco blends...
April 27, 2018: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29700332/mitoq-supplementation-prevent-long-term-impact-of-maternal-smoking-on-renal-development-oxidative-stress-and-mitochondrial-density-in-male-mice-offspring
#18
Suporn Sukjamnong, Yik Lung Chan, Razia Zakarya, Long The Nguyen, Ayad G Anwer, Amgad A Zaky, Rachana Santiyanont, Brian G Oliver, Ewa Goldys, Carol A Pollock, Hui Chen, Sonia Saad
To investigate the effect of maternal MitoQ treatment on renal disorders caused by maternal cigarette smoke exposure (SE). We have demonstrated that maternal SE during pregnancy increases the risk of developing chronic kidney disease (CKD) in adult offspring. Mitochondrial oxidative damage contributes to the adverse effects of maternal smoking on renal disorders. MitoQ is a mitochondria-targeted antioxidant that has been shown to protect against oxidative damage-related pathologies in many diseases. Female Balb/c mice (8 weeks) were divided into Sham (exposed to air), SE (exposed to cigarette smoke) and SEMQ (exposed to cigarette smoke with MitoQ supplemented from mating) groups...
April 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29692875/exercise-training-mitigates-water-pipe-smoke-exposure-induced-pulmonary-impairment-via-inhibiting-nf-%C3%AE%C2%BA-b-and-activating-nrf2-signalling-pathways
#19
Abderrahim Nemmar, Suhail Al-Salam, Priya Yuvaraju, Sumaya Beegam, Badreldin H Ali
Water pipe smoking is a tobacco smoking method commonly used in Eastern countries and is gaining popularity in Europe and North America, in particular among adolescents and young adults. Several clinical and experimental studies have reported that exposure to water pipe smoke (WPS) induces lung inflammation and impairment of pulmonary function. However, the mechanisms of such effects are not understood, as are data on the possible palliative effect of exercise training. The present study evaluated the effects of regular aerobic exercise training (treadmill: 5 days/week, 40 min/day) on subchronic exposure to WPS (30 minutes/day, 5 days/week for 2 months)...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29691142/oxidative-stress-biomarkers-and-clinical-dimensions-in-first-10-years-of-schizophrenia
#20
Leticia González-Blanco, María Paz García-Portilla, Leticia García-Álvarez, Lorena de la Fuente-Tomás, Celso Iglesias García, Pilar A Sáiz, Susana Rodríguez-González, Ana Coto-Montes, Julio Bobes
INTRODUCTION: Several studies have described increased oxidative stress parameters in patients with schizophrenia. The objectives of the current study were to identify potential oxidative stress biomarkers in stable patients during first 10 years of schizophrenia and determine if they are associated with specific clinical dimensions. MATERIAL AND METHODS: Seventy-three clinically stable outpatients with schizophrenia and 73 sex and age-matched healthy controls were recruited...
April 21, 2018: Revista de Psiquiatrí́a y Salud Mental
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