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Smoking and oxidative stress

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https://www.readbyqxmd.com/read/28079158/aryl-hydrocarbon-receptor-ahr-dependent-regulation-of-pulmonary-mirna-by-chronic-cigarette-smoke-exposure
#1
Sarah Rogers, Angela Rico de Souza, Michela Zago, Matthew Iu, Necola Guerrina, Alvin Gomez, Jason Matthews, Carolyn J Baglole
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor historically known for its toxic responses to man-made pollutants such as dioxin. More recently, the AhR has emerged as a suppressor of inflammation, oxidative stress and apoptosis from cigarette smoke by mechanisms that may involve the regulation of microRNA. However, little is known about the AhR regulation of miRNA expression in the lung in response to inhaled toxicants. Therefore, we exposed Ahr(-/-) and Ahr(+/-) mice to cigarette smoke for 4 weeks and evaluated lung miRNA expression by PCR array...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28065790/comparison-of-cellular-and-transcriptomic-effects-between-electronic-cigarette-vapor-and-cigarette-smoke-in-human-bronchial-epithelial-cells
#2
Sébastien Anthérieu, Anne Garat, Nicolas Beauval, Mélissa Soyez, Delphine Allorge, Guillaume Garçon, Jean-Marc Lo-Guidice
The use of electronic cigarette (e-cig) can be considered as an alternative to smoking. However, due to a lack of thorough toxicological studies, absolute safety of these products cannot be guaranteed. The aim of this in vitro work was to investigate the potential toxicity of e-vapors generated by a smoking machine in human bronchial epithelial BEAS-2B cells cultured at air-liquid interface, in comparison to cigarette smoke (CS). Although CS decreased strongly cell viability from 48min exposure, e-vapors induced no cytotoxicity up to 288min exposure...
January 5, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28059114/cigarette-smoke-extract-profoundly-suppresses-tnf%C3%AE-mediated-proinflammatory-gene-expression-through-upregulation-of-atf3-in-human-coronary-artery-endothelial-cells
#3
Jack E Teasdale, Georgina G J Hazell, Alasdair M G Peachey, Graciela B Sala-Newby, Charles C T Hindmarch, Tristan R McKay, Mark Bond, Andrew C Newby, Stephen J White
Endothelial dysfunction caused by the combined action of disturbed flow, inflammatory mediators and oxidants derived from cigarette smoke is known to promote coronary atherosclerosis and increase the likelihood of myocardial infarctions and strokes. Conversely, laminar flow protects against endothelial dysfunction, at least in the initial phases of atherogenesis. We studied the effects of TNFα and cigarette smoke extract on human coronary artery endothelial cells under oscillatory, normal laminar and elevated laminar shear stress for a period of 72 hours...
January 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28048167/su-f-i-66-the-effects-of-nicotinic-agonists-on-rat-hippocampal-glutamatergic-fluctuation-by-using-proton-magnetic-resonance-spectroscopy-at-9-4t
#4
S-I Lim, K-H Song, C-H Yoo, D-C Woo, B-Y Choe
PURPOSE: Nicotine exerts its effects through the activation of nicotinic acetylcholine receptors (nAChRs). Varenicline, a smoking cessation aid, is a partial agonist acting at the α4β2 nAChRs. Although nicotine and varenicline contribute to the reward system at the same time, the influence of the substances on hippocampal neurochemical changes has not been investigated yet. We therefore studied the effects of repeated nicotine exposure and varenicline administration on hippocampus of rats by using in vivo proton magnetic resonance spectroscopy (1H MRS) at 9...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28028404/cigarette-smoking-and-oxidative-stress-in-patients-with-coronary-artery-disease
#5
Gordana Kamceva, Zorica Arsova-Sarafinovska, Tatjana Ruskovska, Milka Zdravkovska, Lidija Kamceva-Panova, Elisaveta Stikova
AIM: To determine whether cigarette smoking, as a risk factor for CAD, affects (anti)oxidant status. MATERIAL AND METHODS: The study included patients with CAD, divided according to their smoking status and the number of cigarettes smoked during a day. Biological markers of oxidative stress (concentration of oxidants and activity of antioxidant enzymes) were measured in all subjects. RESULTS: The study included 300 patients with CAD, (average age of 63 ± 11 years), predominantly males...
December 15, 2016: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28018048/childhood-personality-betrayal-trauma-and-leukocyte-telomere-length-in-adulthood-a-lifespan-perspective-on-conscientiousness-and-betrayal-traumas-as-predictors-of-a-biomarker-of-cellular-aging
#6
Grant W Edmonds, Sarah E Hampson, Hélène C F Côté, Patrick L Hill, Bridget Klest
Conscientiousness is associated with longevity. As such, identifying the biological pathways linking personality to mortality is important. This study employs longitudinal data spanning >40 years to test prospective associations with Leukocyte Telomere Length (LTL), a potential marker of cellular aging. Because telomeres shorten over time, and are sensitive to oxidative stress, shorter LTL may reflect cumulative damage associated with negative health behaviors and past stressful events. We investigated childhood conscientiousness as a protective factor, expecting an association with longer LTL in adulthood, possibly reflecting slower LTL shortening...
September 2016: European Journal of Personality
https://www.readbyqxmd.com/read/28009790/exercise-training-reverses-extrapulmonary-impairments-in-smoke-exposed-mice
#7
T Scott Bowen, Lars Aakerøy, Sophia Eisenkolb, Patricia Kunth, Fredrik Bakkerud, Martin Wohlwend, Anne Marie Ormbostad, Tina Fischer, Ulrik Wisloff, Gerhard Schuler, Sigurd Steinshamn, Volker Adams, Eivind Bronstad
PURPOSE: Cigarette smoking is the main risk factor for chronic obstructive pulmonary disease and emphysema. However, evidence on the extrapulmonary effects of smoke exposure that precede lung impairments remains unclear at present, as are data on non-pharmacological treatments such as exercise training. METHODS: Three groups of mice including control (n=10), smoking (n=10), and smoking with 6 weeks of high-intensity interval treadmill running (n=11) were exposed to 20 weeks of fresh air or whole-body cigarette smoke...
December 22, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28008246/the-administration-of-a-high-refined-carbohydrate-diet-promoted-an-increase-in-pulmonary-inflammation-and-oxidative-stress-in-mice-exposed-to-cigarette-smoke
#8
Karina Braga Pena, Camila de Oliveira Ramos, Nícia Pedreira Soares, Pamela Félix da Silva, Ana Carla Balthar Bandeira, Guilherme de Paula Costa, Sílvia Dantas Cangussú, André Talvani, Frank Silva Bezerra
This study aimed to evaluate the effects of a high refined carbohydrate diet and pulmonary inflammatory response in C57BL/6 mice exposed to cigarette smoke (CS). Twenty-four male mice were divided into four groups: control group (CG), which received a standard diet; cigarette smoke group (CSG), which was exposed to CS; a high refined carbohydrate diet group (RG), which received a high refined carbohydrate diet; and a high refined carbohydrates diet and cigarette smoke group (RCSG), which received a high refined carbohydrate diet and was exposed to CS...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28006950/augmentation-of-s-nitrosoglutathione-gsno-controls-cigarette-smoke-induced-inflammatory-oxidative-stress-and-copd-emphysema-pathogenesis-by-restoring-cftr-function
#9
Manish Bodas, David Silverberg, Kyla Walworth, Kathryn A Brucia, Neeraj Vij
AIMS: Cigarette-smoke (CS) mediated CFTR-dysfunction, autophagy-impairment, and resulting inflammatory-oxidative/nitrosative stress leads to COPD-emphysema pathogenesis. Nitric oxide (NO)-signaling regulates lung function, and low serum NO-levels correlate with COPD severity. We aim to evaluate here the effects and mechanism(s) of GSNO-augmentation in COPD-emphysema pathogenesis. RESULTS: Our data shows that CFTR co-localizes with aggresome-bodies in the lungs of COPD subjects with increasing emphysema severity (GOLD I-IV) as compared to non-emphysema controls (GOLD-0)...
December 22, 2016: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28003846/paeoniflorin-attenuated-oxidative-stress-in-rat-copd-model-induced-by-cigarette-smoke
#10
Jinpei Lin, Fei Xu, Genfa Wang, Lingwen Kong, Qingli Luo, Yvbao Lv, Jiaqi Liu, Ying Wei, Lulu Li, Hongying Zhang, Jingcheng Dong
Paeoniflorin (PF), a monoterpene glucoside, might have an effect on the oxidative stress. However, the mechanism is still unknown. In this study, we made the COPD model in Sprague-Dawley (SD) rats by exposing them to the smoke of 20 cigarettes for 1 hour/day and 6 days/week, for 12 weeks, 24 weeks, or 36 weeks. Our findings suggested that smoke inhalation can trigger the oxidative stress from the very beginning. A 24-week treatment of PF especially in the dosage of 40 mg/kg·d can attenuate oxygen stress by partially quenching reactive oxygen species (ROS) and upregulating antioxidant enzymes via an Nrf2-dependent mechanism...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28002533/smoking-associated-nodular-glomerulosclerosis-a-rare-renal-pathology-resembling-diabetic-nephropathy-case-report
#11
Andreea Gabriella Andronesi, Gener Ismail, Andreea Cătălina Fetecău, Mihaela Gherghiceanu, George Mitroi, Mihai Cristian Hârza
INTRODUCTION: Smoking is an important risk factor not only for cardiovascular and pulmonary diseases, but also for the progression of chronic kidney disease of different etiologies. Nodular glomerulosclerosis is a renal pathology pattern, which was described in different kidney conditions, especially diabetic nephropathy. A very rare association among smoking, hypertension and nodular mesangial glomerulosclerosis has been recently described. CASE PRESENTATION: In this paper, we present the case of a non-diabetic male patient referred to our Department for advanced chronic kidney disease and nephrotic syndrome...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27993944/effects-of-airborne-toxicants-on-pulmonary-function-and-mitochondrial-dna-damage-in-rodent-lungs
#12
William L Rumsey, Brian Bolognese, Alicia B Davis, Pearl L Flamberg, Joseph P Foley, Steven R Katchur, Charles J Kotzer, Ruth R Osborn, Patricia L Podolin
Inhalation of airborne toxicants such as cigarette smoke and ozone is a shared health risk among the world's populations. The use of toxic herbicides like paraquat (PQ) is restricted by many countries, yet in the developing world PQ has demonstrable ill effects. The present study examined changes in pulmonary function, mitochondrial DNA (mtDNA) integrity and markers of DNA repair induced by acute or repeated exposure of PQ to rats. Similar to cigarette smoke and ozone, PQ promotes oxidative stress, and the impact of PQ on mtDNA was compared with that obtained with these agents...
December 18, 2016: Mutagenesis
https://www.readbyqxmd.com/read/27993926/oxidized-ldl-is-associated-with-metabolic-syndrome-traits-independently-of-central-obesity-and-insulin-resistance
#13
Yamilee Hurtado-Roca, Hector Bueno, Antonio Fernandez-Ortiz, Jose Maria Ordovas, Borja Ibañez, Valentin Fuster, Fernando Rodriguez-Artalejo, Martin Laclaustra
This study assesses whether oxidative stress, using oxidized LDL (ox-LDL) as proxy, is associated with metabolic syndrome (MS), whether ox-LDL mediates the association between central obesity and MS, and whether insulin resistance mediates the association between ox-LDL and MS. We examined baseline data from 3987 non-diabetic subjects in the Progression of Early Subclinical Atherosclerosis (PESA) Study. For the 2nd, 3rd, and 4th ox-LDL quartiles versus the 1st, the odds ratios (95% confidence interval) for MS were 0...
December 19, 2016: Diabetes
https://www.readbyqxmd.com/read/27993476/urinary-oxidative-stress-biomarkers-among-local-residents-measured-6years-after-the-hebei-spirit-oil-spill
#14
Jung-Ah Kim, Su Ryeon Noh, Hae-Kwan Cheong, Mina Ha, Sang-Yong Eom, Heon Kim, Myung-Sook Park, Yeonhee Chu, Seung-Hwa Lee, Kyungho Choi
In December 2007, the Hebei Spirit oil spill occurred on the west coast of South Korea. Association between crude oil exposure and the levels of urinary oxidative stress biomarkers was reported among the local residents, 1.5years after the accident. The aim of this study was to follow-up possible longer-term effects of the oil spill among the residents near the oil spill. Six years after the accident, urinary oxidative stress biomarkers of the residents were associated with surrogates of oil exposure. The target subjects were divided into two groups based on the distance of their residence to the spill site, i...
December 16, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27960139/oxidative-stress-inflammation-and-treatment-response-in-major-depression
#15
Daniel Lindqvist, Firdaus S Dhabhar, S Jill James, Christina M Hough, Felipe A Jain, F Saverio Bersani, Victor I Reus, Josine E Verhoeven, Elissa S Epel, Laura Mahan, Rebecca Rosser, Owen M Wolkowitz, Synthia H Mellon
OBJECTIVE: Increased inflammation and oxidative stress have been shown in Major Depressive Disorder (MDD), although there is significant heterogeneity across studies. Whether markers of inflammation and oxidative stress are associated with antidepressant treatment response in MDD is currently unclear. The goals of the present study are to investigate markers of inflammation and oxidative stress in unmedicated MDD subjects and controls and test the relationship between these markers and antidepressant response in MDD subjects...
November 30, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27942209/association-of-serum-ferritin-levels-with-smoking-and-lung-function-in-the-korean-adult-population-analysis-of-the-fourth-and-fifth-korean-national-health-and-nutrition-examination-survey
#16
Chan Ho Lee, Eun Kyung Goag, Su Hwan Lee, Kyung Soo Chung, Ji Ye Jung, Moo Suk Park, Young Sam Kim, Se Kyu Kim, Joon Chang, Joo Han Song
BACKGROUND: Iron-catalyzed oxidative stress contributes to lung injury after exposure to various toxins, including cigarette smoke. An oxidant/antioxidant imbalance is considered to play a critical role in the pathogenesis of COPD. Ferritin is a key protein in iron homeostasis, and its capacity to oxidize and sequester the metal preventing iron prooxidant activity implicates its possible role in the alteration of antioxidant imbalance. We investigated the relationship among cigarette smoking, lung function, and serum ferritin concentration in a large cohort representative of the Korean adult population...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27935962/map3k19-is-overexpressed-in-copd-and-is-a-central-mediator-of-cigarette-smoke-induced-pulmonary-inflammation-and-lower-airway-destruction
#17
Stefen A Boehme, Karin Franz-Bacon, John Ludka, Danielle N DiTirro, Tai Wei Ly, Kevin B Bacon
Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation and lung inflammation resulting in a progressive decline in lung function whose principle cause is cigarette smoke. MAP3K19 is a novel kinase expressed predominantly by alveolar and interstitial macrophages and bronchial epithelial cells in the lung. We found that MAP3K19 mRNA was overexpressed in a limited sampling of lung tissue from COPD patients, and a closer examination found it to be overexpressed in bronchoalveolar macrophages from COPD patients, as well as the bronchial epithelium and inflammatory cells in the lamina propria...
2016: PloS One
https://www.readbyqxmd.com/read/27932354/longitudinal-impact-of-smoking-and-smoking-cessation-on-inflammatory-markers-of-cardiovascular-disease-risk
#18
Cecile C King, Megan E Piper, Adam D Gepner, Michael C Fiore, Timothy B Baker, James H Stein
OBJECTIVE: To evaluate longitudinal changes in 6 inflammatory markers that predict cardiovascular disease events among smokers making a quit attempt and to characterize their cross-sectional associations between smoking and smoking heaviness. APPROACH AND RESULTS: In a longitudinal cohort study of contemporary smokers (n=1652), we evaluated (1) independent associations of smoking heaviness markers (exhaled carbon monoxide, cigarettes/d, pack-years) with inflammatory markers (C-reactive protein, D-dimer, fibrinogen, urinary F2 isoprostane:creatinine [F2:Cr] ratio, white blood cell [WBC] count, myeloperoxidase) and (2) the effects of smoking cessation and continued smoking on these inflammatory markers after 1 year, among the 888 smokers who made an aided quit attempt as part of a randomized comparative effectiveness trial or standard care...
December 8, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27930990/cigarette-smoke-and-related-risk-factors-in-neurological-disorders-an-update
#19
REVIEW
Smilin Bell Aseervatham G, Sangdun Choi, Jayalakshmi Krishnan, Ruckmani K
Cigarette smoking is known to be harmful to health, and is considered the main cause of death worldwide, especially in India. Among the well-distinguished diseases related to smoking are, chronic obstructive pulmonary disease, oral and peripheral cancers, and cardiovascular complications. However, the impact of cigarette smoking on neurocognitive and neuropathological effects, including anxiety, Alzheimer's disease, Parkinson's disease, ischemic stroke, and blood-brain barrier dysfunction, still remains unclear...
January 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27925185/effects-of-carbocysteine-and-beclomethasone-on-histone-acetylation-deacetylation-processes-in-cigarette-smoke-exposed-bronchial-epithelial-cells
#20
E Pace, S Di Vincenzo, M Ferraro, L Siena, G Chiappara, P Dino, P Vitulo, A Bertani, F Saibene, L Lanata, M Gjomarkaj
Histone deacetylase expression/activity may control inflammation, cell senescence, and responses to corticosteroids. Cigarette smoke exposure, increasing oxidative stress, may negatively affect deacetylase expression/activity. The effects of cigarette smoke extracts (CSE), carbocysteine, and beclomethasone dipropionate on chromatin remodelling processes in human bronchial epithelial cells are largely unknown. The present study was aimed to assess the effects of cigarette smoke, carbocysteine, and beclomethasone dipropionate on histone deacetylase 3 (HDAC3) expression/activity, N-CoR (nuclear receptor corepressor) expression, histone acetyltransferases (HAT) (p300/CBP) expression, p-CREB and IL-1 m-RNA expression, neutrophil chemotaxis...
December 7, 2016: Journal of Cellular Physiology
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