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Smoking and oxidative stress

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https://www.readbyqxmd.com/read/28228079/lipid-based-nanoparticles-as-carriers-for-dermal-delivery-of-antioxidants
#1
Lucia Montenegro
The skin, being the outermost layer of our body, is constantly exposed to oxidative stress induced by UV-radiation, pollutants, smoke and xenobiotics. To counteract the deleterious effects of such exposure, the skin is equipped with a complex anti-oxidation system, involving both exogenous and endogenous antioxidants. As low molecular weight antioxidants undergo depletion in counteracting oxidative stress occurring in the skin, topical supplementation with these agents is regarded as a suitable strategy to restore skin oxidative balance...
February 22, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28225026/blood-based-omic-profiling-supports-female-susceptibility-to-tobacco-smoke-induced-cardiovascular-diseases
#2
Aristotelis Chatziioannou, Panagiotis Georgiadis, Dennie G Hebels, Irene Liampa, Ioannis Valavanis, Ingvar A Bergdahl, Anders Johansson, Domenico Palli, Marc Chadeau-Hyam, Alexandros P Siskos, Hector Keun, Maria Botsivali, Theo M C M de Kok, Almudena Espín Pérez, Jos C S Kleinjans, Paolo Vineis, Soterios A Kyrtopoulos
We recently reported that differential gene expression and DNA methylation profiles in blood leukocytes of apparently healthy smokers predicts with remarkable efficiency diseases and conditions known to be causally associated with smoking, suggesting that blood-based omic profiling of human populations may be useful for linking environmental exposures to potential health effects. Here we report on the sex-specific effects of tobacco smoking on transcriptomic and epigenetic features derived from genome-wide profiling in white blood cells, identifying 26 expression probes and 92 CpG sites, almost all of which are affected only in female smokers...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28212524/role-of-nrf2-and-protective-effects-of-metformin-against-tobacco-smoke-induced-cerebrovascular-toxicity
#3
Shikha Prasad, Ravi K Sajja, Mohammad Abul Kaisar, Jee Hyun Park, Heidi Villalba, Taylor Liles, Thomas Abbruscato, Luca Cucullo
Cigarette smoking (CS) is associated with vascular endothelial dysfunction in a causative way primarily related to the TS content of reactive oxygen species (ROS), nicotine, and inflammation. TS promotes glucose intolerance and increases the risk of developing type-2 diabetes mellitus (2DM) with which it shares other pathogenic traits including the high risk of cerebrovascular and neurological disorders like stroke via ROS generation, inflammation, and blood-brain barrier (BBB) impairment. Herein we provide evidence of the role played by nuclear factor erythroid 2-related factor (Nrf2) in CS-induced cerebrobvascular/BBB impairments and how these cerebrovascular harmful effects can be circumvented by the use of metformin (MF; a widely prescribed, firstline anti-diabetic drug) treatment...
February 12, 2017: Redox Biology
https://www.readbyqxmd.com/read/28211083/the-association-between-periodontitis-and-sleep-duration
#4
Mario Romandini, Gioele Gioco, Giorgio Perfetti, Giorgio Deli, Edoardo Staderini, Andreina Laforì
AIM: Due to its potential to influence systemic inflammation and oxidative stress, and to predispose to bacterial infections, sleep duration could potentially be a risk factor for periodontitis. The aim of this cross-sectional study was to evaluate if there was in 2012 an association between periodontitis and sleep duration in a representative sample of the South Korean population. MATERIALS AND METHODS: A total of 5,812 subjects representative of 39.4 million of adults were examined...
February 17, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28209797/roles-of-vascular-oxidative-stress-and-nitric-oxide-in-the-pathogenesis-of-atherosclerosis
#5
REVIEW
Ulrich Förstermann, Ning Xia, Huige Li
Major reactive oxygen species (ROS)-producing systems in vascular wall include NADPH (reduced form of nicotinamide adenine dinucleotide phosphate) oxidase, xanthine oxidase, the mitochondrial electron transport chain, and uncoupled endothelial nitric oxide (NO) synthase. ROS at moderate concentrations have important signaling roles under physiological conditions. Excessive or sustained ROS production, however, when exceeding the available antioxidant defense systems, leads to oxidative stress. Animal studies have provided compelling evidence demonstrating the roles of vascular oxidative stress and NO in atherosclerosis...
February 17, 2017: Circulation Research
https://www.readbyqxmd.com/read/28208905/n-acetylcysteine-combined-with-home-based-physical-activity-effect-on-health-related-quality-of-life-in-stable-copd-patients-a-randomised-controlled-trial
#6
Vijay Tukaram Salve, Jitesh S Atram
INTRODUCTION: Quality of life is adversely affected in Chronic Obstructive Pulmonary Disease (COPD), due to irreversible, progressive nature of the disease and limitations of current treatment options available. One of the important aim of treatment of COPD is to improve Quality of Life (QoL). Cigarette smoke contains numerous free radicals and other oxidants. Oxidative stress has been implicated in pathogenesis, progression of disease and exacerbation in COPD. Pulmonary tuberculosis, outdoor and indoor air pollution and many others are aetiologies of COPD in non-smokers...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28207497/concurrent-presence-of-inflammation-and-obstructive-sleep-apnea-exacerbates-the-risk-of-metabolic-syndrome-a-koges-6-year-follow-up-study
#7
Jinkwan Kim, Dae Wui Yoon, Seung Ku Lee, Seunggwan Lee, Kyung-Mee Choi, Thomas J Robert, Chol Shin
Obstructive sleep apnea (OSA) leads to multiple end-organ morbidities that are mediated by the cumulative burden of oxidative stress and inflammation. Both OSA and inflammation play key roles in increased risk of cardiovascular disease (CVD). Thus, we hypothesized that the combination of inflammation and OSA could accelerate the development of metabolic syndrome (MetS) in a large cohort study.A total of 1835 participants were randomly selected from the ongoing Korean Genome and Epidemiology Study for the years between 2007 and 2015...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28199823/an-experimental-study-of-a-rat-model-of-emphysema-induced-by-cigarette-smoke-exposure-and-the-effect-of-survanta-therapy
#8
Assmaa O Selim, Zienab A Gouda, Sally A Selim
The present study was performed to test the therapeutic effects of Survanta (an exogenous surfactant) on a Wistar rat model of emphysema. Thirty-five adult male Wistar rats were divided randomly into the following groups; control subgroups Ia&b (n=14); emphysematous model subgroups IIa,b&c (n=21) exposed to cigarette smoke (CS), received phosphate buffer solution (PBS) and Survanta respectively. The levels of serum myeloperoxidase (MPO), lung tissue lactate dehydrogenase (LDH), alkaline phosphatase (ALP) as well as antioxidants: catalase (CAT), superoxide dismutase (SOD) and oxidative stress: malondialdehyde (MDA) markers were measured...
February 13, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28198160/oxidative-stress-gene-polymorphisms-may-have-impact-in-the-development-of-ischemic-stroke
#9
Bensu Karahalil, Aylin Elkama, Gürdal Orhan
INTRODUCTION: Antioxidants are responsible for detoxification of harmful effects of ROS. Genetic factors may influence antioxidant activity due to polymorphisms on antioxidant enzymes. These polymorphisms can be risk in ischemic stroke (IS) risk. IS is a disorder with genetic and environmental factors contributing to overall risk. Although there have been a few studies there have been no reports on Catalase; CAT C262T, manganese superoxide dismutase; MnSOD Ala16Val, glutathione peroxidase 1; GPX1 Pro198Leu gene polymorphisms and the risk of IS...
February 15, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/28195077/effects-of-air-pollution-on-the-skin-a-review
#10
REVIEW
Poonam Puri, Shashi Kumar Nandar, Sushruta Kathuria, V Ramesh
The increase in air pollution over the years has had major effects on the human skin. Various air pollutants such as ultraviolet radiation, polycyclic aromatic hydrocarbons, volatile organic compounds, oxides, particulate matter, ozone and cigarette smoke affect the skin as it is the outermost barrier. Air pollutants damage the skin by inducing oxidative stress. Although human skin acts as a biological shield against pro-oxidative chemicals and physical air pollutants, prolonged or repetitive exposure to high levels of these pollutants may have profound negative effects on the skin...
February 7, 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/28188891/3-2-deoxy-%C3%AE-d-erythro-pentafuranosyl-pyrimido-1-2-%C3%AE-purin-10-3h-one-deoxyguanosine-adducts-of-workers-exposed-to-asbestos-fibers
#11
Stefano Bonassi, Filippo Cellai, Armelle Munnia, Donatella Ugolini, Alfonso Cristaudo, Monica Neri, Mirta Milić, Alessandra Bonotti, Roger W Giese, Marco E M Peluso
Asbestos is the commercial name for a group of silicate minerals naturally occurring in the environment and widely used in the industry. Asbestos exposure has been associated with pulmonary fibrosis, mesothelioma, and malignancies, which may appear after a period of latency of 20-40 years. Mechanisms involved in the carcinogenic effects of asbestos are still not fully elucidated, although the oxidative stress theory suggests that phagocytic cells produce large amounts of reactive oxygen species, due to their inability to digest asbestos fiber...
February 7, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28168401/dyslipidemia-in-systemic-lupus-erythematosus
#12
Melinda Zsuzsanna Szabó, Peter Szodoray, Emese Kiss
Cardiovascular disease is one of the major causes of morbidity and mortality in patients with systemic lupus erythematosus (SLE). Accelerated atherosclerosis is related to traditional (age, hypertension, diabetes mellitus, dyslipidemia, obesity, smoking, and positive family history) and non-traditional, disease-related factors. Traditional risk factors are still more prominent in patients with lupus, as both hypertension and hypercholesterinemia were independently associated with premature atherosclerosis in several SLE cohorts...
February 7, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28167231/nicotine-slows-down-oligomerisation-of-%C3%AE-synuclein-and-ameliorates-cytotoxicity-in-a-yeast-model-of-parkinson-s-disease
#13
Jay Kardani, Ratnika Sethi, Ipsita Roy
Several retrospective epidemiological reports have indicated an inverse correlation between smoking and development of Parkinson's disease (PD). This has mostly been attributed to the neuroprotective role of nicotine in stimulating nicotinic acetylcholine receptors and dopaminergic neurons which are damaged in PD. One of the characteristic features of PD is the intraneuronal deposition of globular inclusions of the intrinsically disordered protein α-synuclein as Lewy bodies. Using in vitro and the well-validated yeast cell models, we show that nicotine also exerts a beneficial effect on aggregation of α-synuclein...
February 3, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28164246/immune-mediated-inflammation-in-the-pathogenesis-of-emphysema-insights-from-mouse-models
#14
REVIEW
John M Craig, Alan L Scott, Wayne Mitzner
The cellular mechanisms that result in the initiation and progression of emphysema are clearly complex. A growing body of human data combined with discoveries from mouse models utilizing cigarette smoke exposure or protease administration have improved our understanding of emphysema development by implicating specific cell types that may be important for the pathophysiology of chronic obstructive pulmonary disease. The most important aspects of emphysematous damage appear to be oxidative or protease stress and sustained macrophage activation and infiltration of other immune cells leading to epithelial damage and cell death...
February 6, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28163282/potential-objective-biomarkers-for-fatigue-among-working-women
#15
Chie Ebata, Hitomi Tatsuta, Masayuki Tatmeichi
OBJECTIVE: The prediction of health impairment due to work overload is subjectively assessed based on recognized symptoms; however, objective evaluation is primarily ideal in the field of occupational health. Recently, some biomarkers of autonomic function and/or oxidative stress were reported to be associated with fatigue. This study aimed to preliminarily investigate whether these biomarkers could be objective indicators for fatigue and stress among working women. METHOD: Participants included 118 full-time female workers (mean age 37...
February 4, 2017: Journal of Occupational Health
https://www.readbyqxmd.com/read/28146259/increased-cardiac-sympathetic-activity-and-oxidative-stress-in-habitual-electronic-cigarette-users-implications-for-cardiovascular-risk
#16
Roya S Moheimani, May Bhetraratana, Fen Yin, Kacey M Peters, Jeffrey Gornbein, Jesus A Araujo, Holly R Middlekauff
Importance: Electronic cigarettes (e-cigarettes) have gained unprecedented popularity, but virtually nothing is known about their cardiovascular risks. Objective: To test the hypothesis that an imbalance of cardiac autonomic tone and increased systemic oxidative stress and inflammation are detectable in otherwise healthy humans who habitually use e-cigarettes. Design, Setting, and Participants: Cross-sectional case-control study of habitual e-cigarette users and nonuser control individuals from 2015 to 2016 at the University of California, Los Angeles...
February 1, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28133511/evaluating-the-influence-of-side-stream-cigarette-smoke-at-an-early-stage-of-non-alcoholic-steatohepatitis-progression-in-mice
#17
Jong Won Kim, Hyejin Yun, Seong-Jin Choi, Sang-Hyub Lee, Surim Park, Chae Woong Lim, Kyuhong Lee, Bumseok Kim
Side stream cigarette smoke (SSCS) is known to be as harmful and hazardous to human health as is active smoking. In this study, we investigated the relationship between the exposure to SSCS and its stimulatory and subacute effects on the progression of non-alcoholic steatohepatitis (NASH). A methionine and choline-deficient plus high fat (MCDHF) diet was administered to C57BL/6 mice for 6 weeks. During the first three weeks of MCDHF diet feeding, each diet group was exposed to SSCS (0, 20, 40 μg/L) or fresh air for 2 hrs per day and 5 days per week...
January 2017: Toxicological Research
https://www.readbyqxmd.com/read/28125953/the-effect-of-tobacco-smoke-exposure-on-generation-of-reactive-oxygen-species-and-cellular-membrane-damage-using-a-co-culture-model-system-of-blood-brain-barrier-with-astrocytes
#18
Seung-Beom Seo, Eun Sang Choe, Kwang-Sik Kim, Soon-Mi Shim
Brain tissue is known to be vulnerable to the exposure by tobacco smoke. Tobacco smoke can induce generation of reactive oxygen species (ROS), causing inflammatory activity and blood-brain barrier (BBB) impairment. The aim of the present study was to investigate the effect of tobacco smoke on cell cytotoxicity, generation of ROS, and cellular membrane damage in astrocytes and BBB using a co-culture system. Cell viability of U373MG cells was reduced in a dose-dependent manner, ranging from 96.7% to 40.3% by tobacco smoke condensate (TSC)...
January 1, 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/28125025/inhaled-pollutants-the-molecular-scene-behind-respiratory-and-systemic-diseases-associated-with-ultrafine-particulate-matter
#19
REVIEW
Hussein Traboulsi, Necola Guerrina, Matthew Iu, Dusica Maysinger, Parisa Ariya, Carolyn J Baglole
Air pollution of anthropogenic origin is largely from the combustion of biomass (e.g., wood), fossil fuels (e.g., cars and trucks), incinerators, landfills, agricultural activities and tobacco smoke. Air pollution is a complex mixture that varies in space and time, and contains hundreds of compounds including volatile organic compounds (e.g., benzene), metals, sulphur and nitrogen oxides, ozone and particulate matter (PM). PM0.1 (ultrafine particles (UFP)), those particles with a diameter less than 100 nm (includes nanoparticles (NP)) are considered especially dangerous to human health and may contribute significantly to the development of numerous respiratory and cardiovascular diseases such as chronic obstructive pulmonary disease (COPD) and atherosclerosis...
January 24, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28120834/biomarkers-of-oxidative-stress-in-electroplating-workers-exposed-to-hexavalent-chromium
#20
Chih-Hong Pan, Hueiwang Anna Jeng, Ching-Huang Lai
This study evaluates levels of biomarkers of oxidative DNA damage and lipid peroxidation in 105 male workers at 16 electroplating companies who had been exposed to hexavalent chromium (Cr(VI)). The study participants were 230 non-smoking male workers, comprising 105 electroplating workers who had been exposed to chromium and 125 control subjects who performed office tasks. Personal air samples, spot urine samples, hair samples, fingernail samples and questionnaires were used to quantify exposure to Cr(VI), oxidative DNA damage, lipid peroxidation, and environmental pollutants...
January 25, 2017: Journal of Exposure Science & Environmental Epidemiology
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