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Myocardial regeneration

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https://www.readbyqxmd.com/read/29785790/the-role-of-mirna-regulation-in-fetal-cardiomyocytes-cardiac-maturation-and-the-risk-of-heart-disease-in-adults
#1
Mitchell C Lock, Ross L Tellam, Kimberley J Botting, Kimberley C W Wang, Joseph B Selvanayagam, Doug A Brooks, Mike Seed, Janna L Morrison
Myocardial infarction is a primary contributor towards the global burden of cardiovascular disease. Rather than repairing the existing damage of myocardial infarction, current treatments only address the symptoms of the disease and reducing the risk of a secondary infarction. Cardiac regenerative capacity is dependent on cardiomyocyte proliferation, which concludes soon after birth in humans and precocial species such as sheep. Human fetal cardiac tissue has some ability to repair following tissue damage, whereas a fully matured human heart has minimal capacity for cellular regeneration...
May 22, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29760727/expanded-cd133-cells-from-human-umbilical-cord-blood-improved-heart-function-in-rats-after-severe-myocardial-infarction
#2
Alejandro Correa, Gabriel Salles Ottoboni, Alexandra Cristina Senegaglia, Luiz Guilherme Achcar Capriglione, Nelson Itiro Miyague, Lidiane Maria Boldrini Leite, Valderez Ravaglio Jamur, Carmen Lúcia Kuniyoshi Rebelatto, Márcia Olandoski, Paulo Roberto Slud Brofman
Pharmacological approaches are partially effective in limiting infarct size. Cell therapies using a cell population enriched with endothelial progenitor cells (EPCs) CD133+ have opened new perspectives for the treatment of ischemic areas after infarction. This preclinical study evaluated the effect of intramyocardial transplantation of purified or expanded human umbilical cord blood-derived CD133+ cells on the recovery of rats following acute myocardial infarction (AMI). Histology studies, electrocardiogram, and fluorescence in situ hybridization (FISH) were used to evaluate heart recovery...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29758937/the-controversial-origin-of-pericytes-during-angiogenesis-implications-for-cell-based-therapeutic-angiogenesis-and-cell-based-therapies
#3
Anna Blocki, Sebastian Beyer, Friedrich Jung, Michael Raghunath
Pericytes reside within the basement membrane of small vessels and are often in direct cellular contact with endothelial cells, fulfilling important functions during blood vessel formation and homeostasis. Recently, these pericytes have been also identified as mesenchymal stem cells. Mesenchymal stem cells, and especially their specialized subpopulation of pericytes, represent promising candidates for therapeutic angiogenesis applications, and have already been widely applied in pre-clinical and clinical trials...
2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29751831/intravenous-injection-of-allogeneic-umbilical-cord-derived-multipotent-mesenchymal-stromal-cells-reduces-the-infarct-area-and-ameliorates-cardiac-function-in-a-porcine-model-of-acute-myocardial-infarction
#4
Meikuang Lim, Weiqiang Wang, Lu Liang, Zhi-Bo Han, Zongjin Li, Jie Geng, Meng Zhao, Honghong Jia, Jie Feng, Zhe Wei, Baoquan Song, Jiemin Zhang, Jun Li, Tianwen Liu, Fan Wang, Ting Li, Jianming Li, Yihu Fang, Jianhua Gao, Zhongchao Han
BACKGROUND: Multipotent mesenchymal stromal cell (MSC) therapy has been widely recognized as a feasible strategy for regenerating injured myocardial tissue. However, little is known about the efficacy of intravenous injection of allogeneic umbilical cord (UC) MSCs in preclinical models of porcine myocardial infarction. METHODS: Different dosages of allogeneic UC-MSCs or the vehicle [phosphate-buffered saline (PBS)] were delivered intravenously into an acute myocardial infarction (AMI) porcine model twice after coronary ligation...
May 11, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29750575/unified-nexus-of-macrophages-and-maresins-in-cardiac-reparative-mechanisms
#5
Jeevan Kumar Jadapalli, Ganesh V Halade
Macrophages are immune-sensing "big eater" phagocytic cells responsible for an innate, adaptive, and regenerative response. After myocardial infarction, macrophages predominantly clear the deceased cardiomyocyte apoptotic or necrotic neutrophils to develop a regenerative and reparative program with the activation of the lipoxygenase-mediated maresin (MaR) metabolome at the site of ischemic injury. The specialized proresolving molecule and macrophage mediator in resolving inflammation, MaR-1, produced by human macrophages, has potent defining effects that limit polymorphonuclear neutrophil infiltration, enhance uptake of apoptotic PMNs, regulate inflammation resolution and tissue regeneration, and reduce pain...
May 11, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29746525/expression-of-adhesion-molecules-on-granulocytes-and-monocytes-following-myocardial-infarction-in-rats-drinking-white-wine
#6
Nikolina Režić-Mužinić, Angela Mastelić, Benjamin Benzon, Anita Markotić, Ivana Mudnić, Ivica Grković, Mia Grga, Ana Marija Milat, Nikola Ključević, Mladen Boban
Neutrophils and monocytes through their CD15s, CD11b and CD44 adhesion molecules are implicated in the initiation and resolution of cardiac inflammation as well as in healing processes after the myocardial infarction (MI). The aim of this study was to determine the effect of white wine consumption on granulocyte and monocyte CD15s, CD11b, and CD44 expression 24h after the surgically inflicted MI. Granulocytes and monocytes were analyzed by flow cytometry, using whole blood of male Sprague-Dawley rats that consumed white wine for 4 weeks...
2018: PloS One
https://www.readbyqxmd.com/read/29743563/cell-therapy-trials-for-heart-regeneration-lessons-learned-and-future-directions
#7
REVIEW
Philippe Menasché
The effects of cell therapy on heart regeneration in patients with chronic cardiomyopathy have been assessed in several clinical trials. These trials can be categorized as those using noncardiac stem cells, including mesenchymal stem cells, and those using cardiac-committed cells, including KIT+ cardiac stem cells, cardiosphere-derived cells, and cardiovascular progenitor cells derived from embryonic stem cells. Although the safety of cell therapies has been consistently reported, their efficacy remains more elusive...
May 9, 2018: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/29737151/oxygen-releasing-antioxidant-cryogel-scaffolds-with-sustained-oxygen-delivery-for-tissue-engineering-applications
#8
Parvaiz Ahmad Shiekh, Anamika Singh, Ashok Kumar
With the advancement in biomaterial sciences, tissue engineered scaffolds are developing as a promising strategy for the regeneration of damaged tissues. However, only a few of these scaffolds have been translated into clinical applications. One of the primary drawbacks of the existing scaffolds is the lack of adequate oxygen supply within the scaffolds. Oxygen producing biomaterials have been developed as an alternate strategy but are faced with two major concerns. One is controlling the rate of oxygen generation, and the other is the production of reactive oxygen species...
May 8, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29736937/pericardial-application-as-a-new-route-for-implanting-stem-cell-cardiospheres-to-treat-myocardial-infarction
#9
Jianhua Zhang, Zheng Wu, Zepei Fan, Zixi Qin, Yingwei Wang, Jiayuan Chen, Maoxiong Wu, Yangxin Chen, Changhao Wu, Jingfeng Wang
KEY POINTS: Cardiospheres (CSps) are a promising new form of cardiac stem cells with advantage over other stem cells for myocardial regeneration, but direct implantation of CSps by conventional routes has been limited due to potential embolism. We have implanted CSps into the pericardial cavity and systematically demonstrated its efficacy regarding myocardial infarction. Stem cell potency and cell viability can be optimized in vitro prior to implantation by pre-conditioning CSps with pericardial fluid and hydrogel packing...
May 7, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29735591/the-alchemist-s-nightmare-might-mesenchymal-stem-cells-that-are-recruited-to-repair-the-injured-heart-be-transformed-into-fibroblasts-rather-than-cardiomyocytes
#10
REVIEW
Milton Packer
The injection of mesenchymal stem cells into the injured myocardium to induce cardiac regeneration has yielded disappointing results, conceivably because cells with cardioreparative potential must be supplied for long periods of time to produce a salutary effect. Accordingly, investigators have devised ways of directing such cells to the heart on an ongoing basis: by enhancing the action of endogenous peptides that function as cardiac homing signals (eg, stromal cell-derived factor-1). Stromal cell-derived factor-1 is released during acute cardiac injury and heart failure, but it has a short half-life because of degradation by dipeptidyl peptidase-4...
May 8, 2018: Circulation
https://www.readbyqxmd.com/read/29733514/injectable-hydrogels-for-cardiac-tissue-engineering
#11
REVIEW
Brisa Peña, Melissa Laughter, Susan Jett, Teisha J Rowland, Matthew R G Taylor, Luisa Mestroni, Daewon Park
In light of the limited efficacy of current treatments for cardiac regeneration, tissue engineering approaches have been explored for their potential to provide mechanical support to injured cardiac tissues, deliver cardio-protective molecules, and improve cell-based therapeutic techniques. Injectable hydrogels are a particularly appealing system as they hold promise as a minimally invasive therapeutic approach. Moreover, injectable acellular alginate-based hydrogels have been tested clinically in patients with myocardial infarction (MI) and show preservation of the left ventricular (LV) indices and left ventricular ejection fraction (LVEF)...
May 7, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29721064/coronary-serum-exosomes-derived-from-patients-with-myocardial-ischemia-regulate-angiogenesis-through-the-mir-939-mediated-nitric-oxide-signaling-pathway
#12
Hao Li, Yiteng Liao, Lei Gao, Tao Zhuang, Zheyong Huang, Hongming Zhu, Junbo Ge
Rationale: Angiogenesis is a crucial step towards tissue repair and regeneration after ischemia. The role of circulating exosomes in angiogenic signal transduction has not been well elucidated. Thus, this study aims to investigate the effects of coronary serum exosomes from patients with myocardial ischemia on angiogenesis and to elucidate the underlying mechanisms. Methods and Results: The patients were enrolled according to the inclusion and exclusion criteria. Coronary blood was obtained from the angiography catheter...
2018: Theranostics
https://www.readbyqxmd.com/read/29700121/genetic-lineage-tracing-of-non-myocyte-population-by-dual-recombinases
#13
Yan Li, Lingjuan He, Xiuzhen Huang, Shirin Issa Bhaloo, Huan Zhao, Shaohua Zhang, Wenjuan Pu, Xueying Tian, Yi Li, Qiaozhen Liu, Wei Yu, Libo Zhang, Xiuxiu Liu, Kuo Liu, Juan Tang, Hui Zhang, Dongqing Cai, Ralf H Adams, Qingbo Xu, Kathy O Lui, Bin Zhou
Background -Whether the adult mammalian heart harbors cardiac stem cells (CSCs) for regeneration of cardiomyocytes is an important yet contentious topic in the field of cardiovascular regeneration. The putative myocyte stem cell populations recognized without specific cell markers such as the cardiosphere-derived cells or with markers such as Sca1+ , Bmi1+ , Isl1+ or Abcg2+ CSCs have been reported. Moreover, it remains unclear whether putative CSCs with unknown or unidentified markers exist and give rise to de novo cardiomyocytes in the adult heart...
April 26, 2018: Circulation
https://www.readbyqxmd.com/read/29695981/cardiac-restoration-stemming-from-the-placenta-tree-insights-from-fetal-and-perinatal-cell-biology
#14
REVIEW
Sveva Bollini, Antonietta R Silini, Asmita Banerjee, Susanne Wolbank, Carolina Balbi, Ornella Parolini
Efficient cardiac repair and ultimate regeneration still represents one of the main challenges of modern medicine. Indeed, cardiovascular disease can derive from independent conditions upsetting heart structure and performance: myocardial ischemia and infarction (MI), pharmacological cardiotoxicity, and congenital heart defects, just to name a few. All these disorders have profound consequences on cardiac tissue, inducing the onset of heart failure over time. Since the cure is currently represented by heart transplantation, which is extremely difficult due to the shortage of donors, much effort is being dedicated to developing innovative therapeutic strategies based on stem cell exploitation...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29695975/characterizing-the-key-metabolic-pathways-of-the-neonatal-mouse-heart-using-a-quantitative-combinatorial-omics-approach
#15
Maciej M Lalowski, Susann Björk, Piet Finckenberg, Rabah Soliymani, Miikka Tarkia, Giulio Calza, Daria Blokhina, Sari Tulokas, Matti Kankainen, Päivi Lakkisto, Marc Baumann, Esko Kankuri, Eero Mervaala
The heart of a newborn mouse has an exceptional capacity to regenerate from myocardial injury that is lost within the first week of its life. In order to elucidate the molecular mechanisms taking place in the mouse heart during this critical period we applied an untargeted combinatory multiomics approach using large-scale mass spectrometry-based quantitative proteomics, metabolomics and mRNA sequencing on hearts from 1-day-old and 7-day-old mice. As a result, we quantified 1.937 proteins (366 differentially expressed), 612 metabolites (263 differentially regulated) and revealed 2...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29665002/three-dimensional-collagenous-niche-and-azacytidine-selectively-promote-time-dependent-cardiomyogenesis-from-human-bone-marrow-derived-msc-spheroids
#16
Jyotsna Joshi, Gautam Mahajan, Chandrasekhar R Kothapalli
Endogenous adult cardiac regenerative machinery is not capable of replacing the lost cells following myocardial infarction, often leading to permanent alterations in structure-function-mechanical properties. Regenerative therapies based on delivering autologous stem cells within an appropriate 3D milieu could meet such demand, by enabling homing and directed differentiation of the transplanted cells into lost specialized cell populations. Since type I collagen is the predominant cardiac tissue matrix protein, we here optimized the 3D niche which could promote time-dependent evolution of cardiomyogenesis from human bone marrow-derived mesenchymal stem cells (BM-MSC)...
April 17, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29651156/efficient-differentiation-of-cardiomyocytes-and-generation-of-calcium-sensor-reporter-lines-from-nonhuman-primate-ipscs
#17
Yongshun Lin, Huimin Liu, Michael Klein, John Ostrominski, So Gun Hong, Ravi Chandra Yada, Guibin Chen, Keron Navarengom, Robin Schwartzbeck, Hong San, Zu-Xi Yu, Chengyu Liu, Kaari Linask, Jeanette Beers, Lugui Qiu, Cynthia E Dunbar, Manfred Boehm, Jizhong Zou
Nonhuman primate (NHP) models are more predictive than rodent models for developing induced pluripotent stem cell (iPSC)-based cell therapy, but robust and reproducible NHP iPSC-cardiomyocyte differentiation protocols are lacking for cardiomyopathies research. We developed a method to differentiate integration-free rhesus macaque iPSCs (RhiPSCs) into cardiomyocytes with >85% purity in 10 days, using fully chemically defined conditions. To enable visualization of intracellular calcium flux in beating cardiomyocytes, we used CRISPR/Cas9 to stably knock-in genetically encoded calcium indicators at the rhesus AAVS1 safe harbor locus...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29650632/mechanisms-of-cardiac-repair-and-regeneration
#18
REVIEW
Kathleen M Broughton, Bingyan J Wang, Fareheh Firouzi, Farid Khalafalla, Stefanie Dimmeler, Francisco Fernandez-Aviles, Mark A Sussman
Cardiovascular regenerative therapies are pursued on both basic and translational levels. Although efficacy and value of cell therapy for myocardial regeneration can be debated, there is a consensus that profound deficits in mechanistic understanding limit advances, optimization, and implementation. In collaboration with the TACTICS (Transnational Alliance for Regenerative Therapies in Cardiovascular Syndromes), this review overviews several pivotal aspects of biological processes impinging on cardiac maintenance, repair, and regeneration...
April 13, 2018: Circulation Research
https://www.readbyqxmd.com/read/29643696/heart-regeneration-in-adult-mammals-after-myocardial-damage
#19
REVIEW
Baiping Cui, Yufan Zheng, Lihua Sun, Ting Shi, Ziyu Shi, Lijue Wang, Guoying Huang, Ning Sun
Heart regeneration remains a critical question in current basic research and clinical practice. The adult mammalian heart exhibits a very limited regeneration capacity. In contrast, adult zebrafish and neonatal mice retain a remarkable ability of heart regeneration after damage. Understanding the mechanisms of heart regeneration would be very valuable to help design efficient treatment strategies against myocardial damage and heart failure. While inherent regeneration of the heart occurs after damage with varying efficiency among species, regeneration may also be induced exogenously...
March 2018: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29642402/therapeutic-use-of-stem-cells-for-myocardial-infarction
#20
REVIEW
Mariah Madigan, Rony Atoui
Myocardial infarction is a leading cause of morbidity and mortality worldwide. Although medical and surgical treatments can significantly improve patient outcomes, no treatment currently available is able to generate new contractile tissue or reverse ischemic myocardium. Driven by the recent/novel understanding that regenerative processes do exist in the myocardium-tissue previously thought not to possess regenerative properties-the use of stem cells has emerged as a promising therapeutic approach with high expectations...
April 6, 2018: Bioengineering
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