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https://www.readbyqxmd.com/read/29777901/interrogation-of-ethnomedicinal-plants-for-synthetic-lethality-effects-in-combination-with-deficiency-in-the-dna-repair-endonuclease-rad1-using-a-yeast-cell-based-assay
#1
Hsu Mon Aung, Chananya Huangteerakul, Wittaya Panvongsa, Amornrat N Jensen, Arthit Chairoungdua, Suchada Sukrong, Laran T Jensen
ETHNOPHARMACOLOGICAL RELEVANCE: Plant materials used in this study were selected based on the ethnobotanical literature. Plants have either been utilized by Thai practitioners as alternative treatments for cancer or identified to exhibit anti-cancer properties. AIM OF THE STUDY: To screen ethnomedicinal plants using a yeast cell-based assay for synthetic lethal interactions with cells deleted for RAD1, the yeast homologue of human ERCC4 (XPF) MATERIALS AND METHODS: Ethanolic extracts from thirty-two species of medicinal plants utilized in Thai traditional medicine were screened for synthetic lethal/sick interactions using a yeast cell-based assay...
May 16, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29772722/ethnobotany-phytochemistry-and-pharmacological-effects-of-plants-in-genus-cynanchum-linn-asclepiadaceae
#2
REVIEW
Lu Han, Xiuping Zhou, Mengmeng Yang, Li Zhou, Xinxin Deng, Shijie Wei, Wenping Wang, Zhizhong Wang, Xue Qiao, Changcai Bai
Genus Cynanchum L. belongs to the family Asclepiadaceae, which comprise more than 200 species distributed worldwide. In Chinese medical practice, numerous drugs (such as tablets and powders) containing different parts of plants of this genus are used to treat snake bites, bruises, osteoblasts, rheumatoid arthritis and tumors. A search for original articles published on the cynanchum genus was performed by using several resources, including Flora of China Official Website and various scientific databases, such as PubMed, SciFinder, the Web of Science, Science Direct, and China Knowledge Resource Integrated (CNKI)...
May 16, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29765815/in-vitro-investigation-of-antimicrobial-activities-of-ethnomedicinal-plants-against-dental-caries-pathogens
#3
Mamta Besra, Vipin Kumar
The study aimed to evaluate the antimicrobial activity of medicinal plant extracts against the bacterial pathogens prominent in dental caries. A total of 20 plant species (herbs, shrubs and trees) belonging to 18 genera and 15 families were documented for dental caries. Antimicrobial activity of solvent extracts and essential oil from plants were determined by zone of inhibition on the growth of Streptococcus mutans (MTCC 497) and Lactobacillus acidophilus (MTCC 10307) using the agar well diffusion method. The results of in vitro antimicrobial assay prove that methanol is more successful in the extraction of phytochemicals from plant samples than aqueous solvent, as methanol extracts show higher antimicrobial activity than aqueous extracts against both the test pathogens...
May 2018: 3 Biotech
https://www.readbyqxmd.com/read/29756461/polyphenolic-content-antioxidant-and-antimicrobial-activities-of-vernonia-mespilifolia-less-used-in-folk-medicine-in-the-eastern-cape-province-south-africa
#4
Jeremiah Oshiomame Unuofin, Gloria Aderonke Otunola, Anthony Jide Afolayan
Vernonia mespilifolia Less. is a shrub of the Asteraceae family used in the South African traditional medicine system for the management of weight loss, hypertension, and heartwater disease. There is a need for scientific evaluation to validate its ethnomedicinal usage. In vitro assays were conducted to evaluate the polyphenolic content, antioxidant and antimicrobial properties of different solvent extracts (acetone, aqueous, and ethanol) of the whole plant of Vernonia mespilifolia spectrophotometric and agar dilution techniques, respectively...
January 2018: Journal of evidence-based integrative medicine
https://www.readbyqxmd.com/read/29740242/ethnomedicinal-assessment-of-irula-tribes-of-walayar-valley-of-southern-western-ghats-india
#5
Arjunan Venkatachalapathi, Thekkan Sangeeth, Mohammad Ajmal Ali, Sulur Senniyappan Tamilselvi, Subramaniyam Paulsamy, Fahad M A Al-Hemaidc
The present study was aimed to explore the traditional knowledge of Irula tribal people who are practicing herbal medicine in Walayar valley, the Southern Western Ghats, India. A total number of 146 species of plants distributed in 122 genera belonging to 58 families were identified as commonly used ethnomedicinal plants by them. Interestingly, 26 new claims were also made in the present study. Through the data obtained from Irula tribal healers, the herbs were mostly used for medicine (40.4%) followed by trees (26...
May 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29736387/traditional-plants-used-for-the-treatment-of-gynaecological-disorders-in-vedaranyam-taluk-south-india-an-ethnomedicinal-survey
#6
S Balamurugan, S Vijayakumar, S Prabhu, J E Morvin Yabesh
Gynaecological disorder is one of the most severe conditions under reproductive health. So we investigate and collect information from traditional practitioners on the use of medicinal plants for treatment of Gynaecological disorder in Vedaranyam taluk, Nagappattinam district of South India. The field study was carried out for a period of January 2014-January 2015 in Vedaranyam taluk, Nagappattinam district of South India. This is the first traditional medicine study in which statistical calculations about plants are done by RFC, CI, UV and ICF in the study area...
April 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29736381/usage-biological-activity-and-safety-of-selected-botanical-dietary-supplements-consumed-in-the-united-states
#7
REVIEW
P Annécie Benatrehina, Li Pan, C Benjamin Naman, Jie Li, A Douglas Kinghorn
In view of the continuous growth of the botanical dietary supplement industry and the increased popularity of lesser known or exotic botanicals, recent findings are described on the phytochemical composition and biological activities of five selected fruits consumed in the United States, namely, açaí, noni, mangosteen, black chokeberry, and maqui berry. A review of the ethnomedicinal uses of these plants has revealed some similarities ranging from wound-healing to the treatment of fever and infectious diseases...
April 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29734660/syzygium-cordatum-hochst-ex-krauss-an-overview-of-its-ethnobotany-phytochemistry-and-pharmacological-properties
#8
REVIEW
Alfred Maroyi
Syzygium cordatum is a valuable medicinal plant in the materia medica of east and southern Africa. The aim of this study was to review the botany, medicinal uses, phytochemistry and ethnopharmacological properties of S. cordatum . Relevant literature search was carried out using internet sources such as ACS, Web of Science, Wiley, SpringerLink, Scopus, Mendeley, Google Scholar, Pubmed, SciFinder, BioMed Central, Science Direct and Elsevier. Other literature sources were conference papers, book chapters, books, theses and websites...
May 4, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29733944/anti-inflammatory-activity-of-theobroma-cacao-l-stem-bark-ethanol-extract-and-its-fractions-in-experimental-models
#9
Sabitiu A Oyeleke, Abayomi M Ajayi, Solomon Umukoro, A O Aderibigbe, Olusegun George Ademowo
ETHNOPHARMACOLOGICAL RELEVANCE: The stem bark of Theobroma cacao L. have been used for the treatment of inflammation, toothache, measles and malaria in ethnomedicine. However, the anti-inflammatory activity of Theobroma cacao stem bark has not been fully elucidated. AIM: The anti-inflammatory activity of Theobroma cacao stem bark ethanol extract and its fractions was investigated in this study. MATERIALS AND METHODS: The anti-inflammatory effect of ethanol extract of Theobroma cacao stem bark (EETc) and its dichloromethane (DCMF), ethylacetate (EAF) and aqueous (AQF) fractions was investigated in erythrocytes membrane stabilizing assay and carrageenan-induced paw oedema...
May 4, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29733943/hajrul-yahood-lapis-judaicus-an-important-mineral-drug-of-unani-system-of-medicine-for-the-management-of-urolithiasis
#10
REVIEW
Shaikh Ajij Ahmed Makbul, Nasreen Jahan, Ghufran Ahmad
ETHNOPHARMACOLOGICAL RELEVANCE: Hajrul yahood (Lapis judaicus) is a mineral drug used in different dosage forms in Unani system of medicine and claimed to be effective in the management of urolithiasis. AIM OF THE STUDY: To explore the role of Hajrul yahood in the management of urolithiasis along with determination of its morphological, ethnomedicinal, physicochemical and pharmacological attributes. MATERIALS AND METHODS: A review of literature on Hajrul yahood was undertaken using the bibliographic database viz...
May 4, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29709412/phytochemical-profile-and-pharmacological-activity-of-aegle-marmelos-linn
#11
REVIEW
Bikash Manandhar, Keshav Raj Paudel, Biraj Sharma, Rajendra Karki
Aegle marmelos Linn. (Rutaceae), commonly known as "bael" in Nepal and India, is a valuable medicinal plant and is considered sacred by the Hindus. It is used to cure several diseases in the Indian traditional medicine system of Ayurveda and has had similar uses among many ethnic communities residing in Indian subcontinent for over 5000 years. Its leaves, bark, stem, fruits and seeds have been used for various medicinal purposes. Bael fruits are especially effective in the treatment of chronic diarrhea, dysentery and peptic ulcers, while they are also useful as a laxative and cure for respiratory infections...
April 21, 2018: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29704040/medicinal-components-in-termitomyces-mushrooms
#12
REVIEW
Huei-Mei Hsieh, Yu-Ming Ju
Termitomyces is a genus of edible mushrooms commonly consumed in Africa and Asia among the mushrooms collected from the wild. Termitomyces mushrooms grow as symbionts in the termite nests, where they produce various enzymes to help termites digest lignocellulosic substrates. Many species of Termitomyces are used by different ethnic groups with ethnomedicinal knowledge. Bioactive components that Termitomyces mushrooms contain have potential uses as antioxidants, immunomodulators, antitumors, and antimicrobials...
April 27, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29695281/quantitative-study-of-medicinal-plants-used-by-the-communities-residing-in-koh-e-safaid-range-northern-pakistani-afghan-borders
#13
Wahid Hussain, Lal Badshah, Manzoor Ullah, Maroof Ali, Asghar Ali, Farrukh Hussain
BACKGROUND: The residents of remote areas mostly depend on folk knowledge of medicinal plants to cure different ailments. The present study was carried out to document and analyze traditional use regarding the medicinal plants among communities residing in Koh-e-Safaid Range northern Pakistani-Afghan border. METHODS: A purposive sampling method was used for the selection of informants, and information regarding the ethnomedicinal use of plants was collected through semi-structured interviews...
April 25, 2018: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/29681858/aqueous-extract-of-black-maca-prevents-metabolism-disorder-via-regulating-the-glycolysis-gluconeogenesis-tca-cycle-and-ppar%C3%AE-signaling-activation-in-golden-hamsters-fed-a-high-fat-high-fructose-diet
#14
Wenting Wan, Hongxiang Li, Jiamei Xiang, Fan Yi, Lijia Xu, Baoping Jiang, Peigen Xiao
Maca ( Lepidium meyenii Walpers) has been used as a dietary supplement and ethnomedicine for centuries. Recently, maca has become a high profile functional food worldwide because of its multiple biological activities. This study is the first explorative research to investigate the prevention and amelioration capacity of the aqueous extract of black maca (AEM) on high-fat, high-fructose diet (HFD)-induced metabolism disorder in golden hamsters and to identify the potential mechanisms involved in these effects...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29651245/antiseptic-activity-of-ethnomedicinal-xuebijing-revealed-by-the-metabolomics-analysis-using-uhplc-q-orbitrap-hrms
#15
Lihua Zuo, Lin Zhou, Tanye Xu, Zhuolun Li, Liwei Liu, Yingying Shi, Jian Kang, Guanmin Gao, Shuzhang Du, Zhi Sun, Xiaojian Zhang
Xuebijing (XBJ) injection is an ethnomedicinal formula that has been widely used in the therapy of sepsis in China. However, the underlying theraputic mechanisms remain uninvestigated. In this research, a metabolomic method based on UHPLC-Q-Orbitrap HRMS was applied to make a holistic evaluation of XBJ on septic rats which were induced by the classical cecal ligation and puncture (CLP) operation. The plasma metabolic changes were profiled and evaluated by multivariate analytical (MVA) methods. In the results, a total of 41 differential metabolites were identified between CLP-operated group and sham-operated group, which were mainly involved in amino acid metabolism and lipid metabolism...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29626672/the-suppressive-effects-of-vochysia-divergens-aqueous-leaf-extract-and-its-5-methoxyflavone-on-murine-macrophages-and-lymphocytes
#16
Maria Fernanda Paresqui Corrêa, Thatiana Lopes Biá Ventura, Michelle Frazão Muzitano, Elaine Dos Anjos da Cruz, Maria Camilla Bergonzi, Anna Rita Bilia, Bartira Rossi-Bergmann, Sônia Soares Costa
ETHNOPHARMACOLOGICAL RELEVANCE: Leaf infusion from the tree Vochysia divergens Pohl (Vochysiaceae), known as "cambará", is used in Brazilian popular medicine against respiratory infections and asthma. AIM OF THE STUDY: To evaluate the health-beneficial effects related to the ethnomedicinal uses of V. divergens (Vd), a biomonitored fractionation of an aqueous leaf extract was carried out. MATERIALS AND METHODS: Leaves were extracted by decoction with distilled water, and the extract fractionated by a combination of separation techniques including precipitation, organic partition and chromatography...
April 4, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29625273/botany-ethnomedicines-phytochemistry-and-pharmacology-of-himalayan-paeony-paeonia-emodi-royle
#17
REVIEW
Mushtaq Ahmad, Khafsa Malik, Akash Tariq, Guolin Zhang, Ghulam Yaseen, Neelam Rashid, Shazia Sultana, Muhammad Zafar, Kifayat Ullah, Muhammad Pukhtoon Zada Khan
ETHNOPHARMACOLOGICAL RELEVANCE: Himalayan paeony (Paeonia emodi Royle.) is an important species used to treat various diseases. This study aimed to compile the detailed traditional medicinal uses, phytochemistry, pharmacology and toxicological investigations on P. emodi. This study also highlights taxonomic validity, quality of experimental designs and shortcomings in previously reported information on Himalayan paeony. METHODS: The data was extracted from unpublished theses (Pakistan, China, India and Nepal), and different published research articles confined to pharmacology, phytochemistry and antimicrobial activities using different databases through specific keywords...
April 3, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29622910/ethnomedicine-claim-directed-in-silico-prediction-of-anticancer-activity
#18
Biniyam Girma, Eshetu Mulisa, Shibru Tessema, Wote Amelo
Background: The merits of ethnomedicine-led approach to identify and prioritize anticancer medicinal plants have been challenged as cancer is more likely to be poorly understood in traditional medicine practices. Nonetheless, it is also believed that useful data can be generated by combining ethnobotanical findings with available scientific studies. Thus, this study combined an ethnobtanical study with ligand based in silico screening to identify relevant medical plants and predict their anticancer potential based on their phytoconstiutents reported in scientific literatures...
January 2018: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29610939/antibacterial-potential-of-secondary-metabolites-produced-by-aspergillus-sp-an-endophyte-of-mitrephora-wangii
#19
Sakon Monggoot, Tanakrit Pichaitam, Chutima Tanapichatsakul, Patcharee Pripdeevech
Mitrephora wangii, an ethnomedicinal plant, has been used as a natural antibiotic and immunity booster in Thailand. A total of 22 fungi were isolated from M. wangii flowers. The fungal isolates were categorized into six genera including Agrocybe, Aspergillus, Colletotrichum, Nigrospora, Puccinia and Ustilago. Most extracts exhibited antibacterial activity against at least one of the test bacteria. Aspergillus sp. MFLUCC16-0845 was identified as the most bioactive fungus. Chemical composition of Aspergillus sp...
April 2, 2018: Archives of Microbiology
https://www.readbyqxmd.com/read/29596999/tithonia-diversifolia-hemsl-a-gray-as-a-medicinal-plant-a-comprehensive-review-of-its-ethnopharmacology-phytochemistry-pharmacotoxicology-and-clinical-relevance
#20
REVIEW
Alex Mabou Tagne, Franca Marino, Marco Cosentino
ETHNOPHARMACOLOGICAL RELEVANCE: Tithonia diversifolia (TD) is widely valued in several cultures for its medicinal properties. A comprehensive review of the current understanding of this plant species is required due to emerging concerns over its efficacy, toxicity and allergenic potential. AIM OF THE REVIEW: We critically summarized the current evidence on the botany, traditional use, phytochemistry, pharmacology and safety of TD, with the view to provide perspectives for developing more attractive pharmaceuticals of plant origin, but also to lay a new foundation for further investigations on this plant...
March 26, 2018: Journal of Ethnopharmacology
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