keyword
https://read.qxmd.com/read/38537009/transient-receptor-potential-melastatin-7-trpm7-ion-channel-inhibitors-preliminary-sar-and-conformational-studies-of-xenicane-diterpenoids-from-the-hawaiian-soft-coral-sarcothelia-edmondsoni
#1
JOURNAL ARTICLE
Guangmin Yao, Matthew R Parris, W Cedric Kuo, Peter Pörzgen, Brandi Castillo, Evan S Mason, Andres Chinchilla, Junhao Huang, Sayuri Suzuki, Rylee Ross, Ellis Akana, Savana Vander Schuit, Steven P Miller, Reinhold Penner, Hong-Shuo Sun, Zhong-Ping Feng, Kenneth G Hull, Daniel Romo, Andrea Fleig, F David Horgen
Waixenicin A, a xenicane diterpene from the octocoral Sarcothelia edmondsoni , is a selective, potent inhibitor of the TRPM7 ion channel. To study the structure-activity relationship (SAR) of waixenicin A, we isolated and assayed related diterpenes from S. edmondsoni . In addition to known waixenicins A ( 1 ) and B ( 2 ), we purified six xenicane diterpenes, 7 S ,8 S -epoxywaixenicins A ( 3 ) and B ( 4 ), 12-deacetylwaixenicin A ( 5 ), waixenicin E ( 6 ), waixenicin F ( 7 ), and 20-acetoxyxeniafaraunol B ( 8 )...
March 27, 2024: Journal of Natural Products
https://read.qxmd.com/read/38536967/uncovering-the-power-of-hsccc-separation-of-diastereomeric-and-regioisomeric-styrylpyrones-from-the-stem-bark-of-goniothalamus-leiocarpus
#2
JOURNAL ARTICLE
Xiao Liu, Ling-Yun Li, Zhi-Qin Zhang, Xiu-Chuan Fu, Rong-Sheng Li, Jia-Li Yao, Simon Gibbons, Qing Mu
The plant Goniothalamus leiocarpus of the Annonaceae family is used as an alternative medicine in tropical regions. Applying high-speed counter current chromatography (HSCCC), eight new bioactive styrylpyrone isomers, including 6 R ,7 S ,8 R ,2' S -goniolactone B ( 1 ), 6 S ,7 S ,8 S ,2' S -goniolactone B ( 2 ), 6 R ,7 R ,8 R ,2' S -goniolactone B ( 3 ), 6 R ,7 S ,8 S ,2' S -goniolactone C ( 4 ), 6 R ,7 S ,8 R ,2' S -goniolactone C ( 5 ), 6 S ,7 R ,8 S ,2' S -goniolactone C ( 6 ), and two positional isomers, 6 R ,7 R ,8 R ,2' S -goniolactone G ( 7 ) and 6 S ,7 R ,8 R ,2' S -goniolactone G ( 8 ), were isolated from a chloroform fraction (2...
March 27, 2024: Journal of Natural Products
https://read.qxmd.com/read/38531432/the-chemometrics-analysis-and-integrated-pharmacology-approach-to-decipher-the-effect-and-mechanism-between-raw-and-processed-cistanche-tubulosa
#3
JOURNAL ARTICLE
Xing-Yue Zhang, Qi-Wu Jiang, Su-Han Yang, Ping Li, Zhi-Yong Chang, Fei Li
ETHNOPHARMACOLOGICAL RELEVANCE: Cistanche tubulosa (CT) is the dried fleshy stem with scaly leaves of Cistanche tubiflora (Schenk) Wight, which has the effects of tonifying the kidney-yang, benefiting the vital essence and blood, and moisturizing the intestines and laxatives. There are differences in the activity of CT before and after processing, but the mechanism of processing is not clear. AIM OF THE STUDY: The study aimed to compare the strength of action of CT before and after yellow-wine processing in the treatment of constipation and kidney yang deficiency and to identify the active ingredients responsible for the differences in activity before and after yellow-wine processing...
March 24, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38531431/triterpenes-g-a-and-g-e-from-galphimia-glauca-with-anti-inflammatory-and-anti-arthritic-activity-in-mice
#4
JOURNAL ARTICLE
Santillan-Urquiza Mayra Alejandra, Pérez Salud, Vega-Avila Elisa, Jiménez-Ferrer Enrique, Rendón-Martínez Julissa, Tortoriello Jaime, Zamilpa Alejandro, Salinas-Sánchez David, Maribel Herrera-Ruiz
ETHNOPHARMACOLOGICAL RELEVANCE: Galphimia glauca is a medicinal plant that treats inflammatory and anti-rheumatic problems. Its anti-inflammatory capacity has been reported pharmacologically, attributed to the triterpenes G-A and G-E. AIM: The objective of the present work was to measure the anti-inflammatory and immunomodulatory effect of the methanolic extract (GgMeOH) of Galphimia glauca and the isolated galphimines G-A and G-E, first in an acute test of plantar edema with carrageenan, and later in the model of experimental-induced arthritis with CFA...
March 24, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38530577/bajitianwan-formula-extract-ameliorates-bone-loss-induced-by-iron-overload-via-activating-rage-pi3k-akt-pathway-based-on-network-pharmacology-and-transcriptomic-analysis
#5
JOURNAL ARTICLE
Weifan Xu, Tao Jiang, Luying Ding, Yiping Jiang, Lichao Zhang, Tianshuang Xia, Hailiang Xin
Osteoporosis (OP) is closely related to iron overload. Bajitianwan (BJTW) is a traditional Chinese medicine formulation used for treating senile diseases such as dementia and osteoporosis. Modern pharmacological researches have found that BJTW has beneficial effect on bone loss and memory impairment in aging rats. This paper aimed to explore the role and mechanism of BJTW in ameliorating iron overload-induced bone loss. Furthermore, BJTW effectively improved the bone micro-structure of the femur in mice, and altered bone metabolism biomarkers alkaline phosphatase (ALP) and osteocalcin (OCN) in serum, as well as oxidative indexes superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR) glutathione (GSH) and malondialdehyde (MDA) in liver...
March 26, 2024: Journal of Natural Medicines
https://read.qxmd.com/read/38528772/glucose-uptake-stimulating-metabolites-from-aerial-parts-of-centaurea-sicula
#6
JOURNAL ARTICLE
Elena Serino, Daniela Rigano, Maurizio Bruno, Arianna Pastore, Mariano Stornaiuolo, Carmen Formisano, Orazio Taglialatela-Scafati
A comprehensive phytochemical investigation of aerial parts obtained from Centaurea sicula L. led to the isolation of 14 terpenoids ( 1 - 14 ) and nine polyphenols ( 15 - 23 ). The sesquiterpenoid group ( 1 - 11 ) included three structural families, namely, elemanolides ( 1 - 6 ), eudesmanolides ( 7 and 8 ), and germacranolides ( 9 - 11 ) with four unreported secondary metabolites ( 5 - 8 ), whose structure has been determined by extensive spectroscopic analysis, including 1D/2D NMR, HR-MS, and chemical conversion...
March 25, 2024: Journal of Natural Products
https://read.qxmd.com/read/38527575/exploring-the-dietary-and-therapeutic-potential-of-licorice-glycyrrhiza-uralensis-fisch-sprouts
#7
JOURNAL ARTICLE
Yong-Sung Park, Sang-Mo Kang, Yeon-Ji Kim, In-Jung Lee
ETHNOPHARMACOLOGICAL RELEVANCE: This research substantiates the traditional use of Glycyrrhiza uralensis Fisch. for liver health, with scientific evidence of the non-toxic and lipid-lowering properties of licorice sprout extracts. The sprouts' rich mineral and amino acid content, along with their strong antioxidant activity, reinforce their value in traditional medicine. These findings bridge ancient herbal practices with modern science, highlighting licorice's potential in contemporary therapeutic applications...
March 23, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38527574/xiaoer-niuhuang-qingxin-powder-alleviates-influenza-a-virus-infection-by-inhibiting-the-activation-of-the-tlr4-myd88-nf%C3%AE%C2%BAb-signaling-pathway
#8
JOURNAL ARTICLE
Lanying Ma, Tong Wang, Meiyi Liu, Lingyun Ji, Yanan Wang, Shuting Li, YaNan Zhang, Yuan Wang, WenXiao Zhao, ZhiChun Wu, HuaYun Yu, HaiJun Zhao
ETHNOPHARMACOLOGICAL RELEVANCE: Xiaoer Niuhuang Qingxin Powder (XNQP) is a classic traditional Chinese medicine formula with significant clinical efficacy for treating febrile convulsions and influenza. AIM OF THE STUDY: This study aims to explore the potential mechanisms of XNQP in combating combating the influenza A virus, providing a theoretical basis for its clinical application. MATERIALS AND METHODS: The present investigation employed network pharmacology and bioinformatics analysis to determine the TLR4/MYD88/NF-κB signaling pathway as a viable target for XNQP intervention in IAV infection...
March 23, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38527573/anti-inflammatory-effects-and-related-mechanisms-in-vitro-and-in-vivo-of-hedychium-coccineum-rhizome-essential-oil
#9
JOURNAL ARTICLE
Minyi Tian, Dan Xie, Yi Hong, Furong Ding, Xia Wu, Dongxin Tang
ETHNOPHARMACOLOGICAL RELEVANCE: Hedychium coccineum rhizome is an anti-inflammatory ethnomedicine used to remedy inflammation-related swelling and bronchial asthma. AIM OF THE STUDY: The study aimed to analyze the phytochemical constituents of H. coccineum rhizome essential oil (EO) and evaluate its in vitro and in vivo anti-inflammatory effects and underlying mechanisms. MATERIALS AND METHODS: Phytochemical constituents of H. coccineum rhizome EO were analyzed using GC-FID/MS...
March 23, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38524312/pharmaceutical-terminology-in-ancient-and-medieval-time-andrachne-chrysocolla-and-others
#10
JOURNAL ARTICLE
Barbara Zipser, Andrew C Scott, Robert Allkin, Peretz Gan, Andreas Lardos, Rebecca Lazarou, Efraim Lev, Mark Nesbitt, Kristina Patmore
Ancient and medieval pharmacological and medical texts contain a substantial amount of plant and mineral names. In some cases, the identification is straightforward. But for the majority of the data, we are unable to identify these ingredients with high certainty. In this paper, we discuss a selection of plant and mineral names both from a humanities and sciences point of view. In one case, the scientists were even able to examine a plant in situ. The conclusion of our paper is that a close collaboration between sciences and humanities is essential to avoid mistakes in the identification of materia medica ...
December 30, 2023: Stud Ceranea
https://read.qxmd.com/read/38522625/effects-of-tibetan-medicine-longdan-zhike-tablet-on-chronic-obstructive-pulmonary-disease-through-mapk-pathway
#11
JOURNAL ARTICLE
Yulin Feng, Pengfei Qin, Rong Wang, Yahui Mi, You Li, Jiahao Feng, Wenbin Shen, Haijuan Dong, Jietai Duo, Liming Ma, Xiaowu Yao, Xiaolong Hu, Fei Xiong, Xinhong Shi, Hao Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Longdan zhike tablet (LDZK) is a Tibetan medicine formula commonly used in the highland region of Tibet, China, to ameliorate respiratory diseases, such as acute bronchitis and asthma. In Chinese traditional medicine, some herbal formulas with anti-inflammatory properties targeting the respiratory system are clinically adopted as supplementary therapies for chronic obstructive pulmonary disease (COPD). However, the specific anti-COPD effects of LDZK remain to be evaluated...
March 22, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38521693/corrigendum-to-effects-of-a-rhizome-aqueous-extract-of-dioscorea-batatas-and-its-bioactive-compound-allantoin-in-high-fat-diet-and-streptozotocin-induced-diabetic-mice-and-the-regulation-of-liver-pancreas-and-skeletal-muscle-dysfunction-j-ethnopharmacol-259
#12
Junnan Ma, Xianglong Meng, Yi Liu, Cheng Yin, Tong Zhang, Piao Wang, Yong-Ki Park, Hyo Won Jung
No abstract text is available yet for this article.
March 22, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38521433/antihyperglycemic-and-antihyperlipidemic-effects-of-fruit-extract-of-hodgsonia-heteroclita-roxb-hook-f-thomson-in-diabetic-mice
#13
JOURNAL ARTICLE
Silu Basumatary, Partha Pradip Adhikari, Ajit Kumar Das, Nanjian Raaman, Gauri Dutt Sharma, Jatin Sarmah, Anjum Dihingia, Rinku Baishya, Prasenjit Manna, Jatin Kalita
ETHNOPHARMACOLOGICAL RELEVANCE: Hodgsonia heteroclita has been known as an important traditionally consumed medicinal plant of North-East India known to have antidiabetic properties. This study aims to investigate the effects of the ethanolic fruit extract of Hodgsonia heteroclita against hyperglycemia and hyperlipidemia by using streptozotocin (STZ) treated diabetic mice. MATERIALS AND METHODS: The fruits of H. heteroclita were collected from the various parts of Kokrajhar district, Assam India (Geographic coordinates: 26°24'3...
March 21, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38521432/a-systematic-review-on-polysaccharides-from-morinda-officinalis-how-advances-in-the-preparation-structural-characterization-and-pharmacological-activities
#14
REVIEW
Mengyun Liu, Chen Wang, Hongwei Zhang, Hui Guo, Le Kang, Hongwei Li, Kai Li
ETHNOPHARMACOLOGICAL RELEVANCE: Morinda officinalis How is called "Ba-Ji-Tian" in Traditional Chinese Medicine (TCM), which belongs to the genus Rubiaceae and is widely used for medicinal purposes in China and other eastern Asian countries. Morinda officinalis How polysaccharides (MOPs) are one of the key bioactive components, and have a variety of biological activities, such as antioxidation, antifatigue, enhanced immunity, antiosteoporosis, ect. AIM OF THE REVIEW: This review is aimed at providing comprehensive information of the latest preparation technologies, structural characterization, and pharmacological effects of MOPs...
March 21, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38521431/qixian-granule-inhibits-ferroptosis-in-vascular-endothelial-cells-by-modulating-trpml1-in-the-lysosome-to-prevent-postmenopausal-atherosclerosis
#15
JOURNAL ARTICLE
Meng Zhang, Chenhan Mao, Yang Dai, Xiaojin Xu, Xindong Wang
ETHNOPHARMACOLOGICAL RELEVANCE: QiXian Granule (QXG) is an integrated traditional Chinese medicine formula used to treat postmenopausal atherosclerotic (AS) cardiovascular diseases. The previous studies have found that QXG inhibited isoproterenol (ISO)-induced myocardial remodeling. And its active ingredient, Icraiin, can inhibit ferroptosis by promoting oxidized low-density lipoprotein (xo-LDL)-induced vascular endothelial cell injury and autophagy in atherosclerotic mice. Another active ingredient, Salvianolic Acid B, can suppress ferroptosis and apoptosis during myocardial ischemia/reperfusion injury by reducing ubiquitin-proteasome degradation of Glutathione Peroxidase 4 (GPX4) and down-regulating the reactive oxygen species (ROS)- c-Jun N-terminal kinases (JNK)/mitogen-activated protein kinase (MAPK) pathway...
March 21, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38521430/antibacterial-and-anti-coronavirus-investigation-of-selected-senegalese-plant-species-according-to-an-ethnobotanical-survey
#16
JOURNAL ARTICLE
Abda Ba, Vincent Roumy, Malak Al Ibrahim, Imelda Raczkiewicz, Jennifer Samaillie, Asma Hakem, Sevser Sahpaz, Sandrine Belouzard, William Diatta, Mamadou Sidybé, Christel Neut, Karin Séron, Matar Seck, Céline Rivière
ETHNOPHARMACOLOGICAL RELEVANCE: In Senegal, upper and lower respiratory tract infections constitute a real health problem. To manage these disorders, most people rely on the use of local medicinal plants. This is particularly the case for species belonging to the botanical families, Combretaceae, Fabaceae, Myrtaceae and Rubiaceae, which are widely used to treat various respiratory problems such as colds, flu, rhinitis, sinusitis, otitis, angina, bronchitis, bronchiolitis and also pneumonia...
March 21, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38521429/orcinol-gentiobioside-inhibits-rankl-induced-osteoclastogenesis-by-promoting-apoptosis-and-suppressing-autophagy-via-the-jnk1-signaling
#17
JOURNAL ARTICLE
Chenxia Lian, Wan Gong, Xuan Zhao, Peng Sun, Sijing Hu, Guifen Zhou, Qiaoyan Zhang, Luping Qin
ETHNOPHARMACOLOGICAL RELEVANCE: Osteoporosis is a metabolic disorder characterizecby disrupted osteoclastic bone resorption and osteoblastic bone formation. Curculigo orchioides Gaertn has a long history of application in traditional Chinese and Indian medicine for treating OP. Orcinol gentiobioside (OGB) is a principal active constituent derived from Curculigo orchioides Gaertn and has been shown to have anti-OP activity. However, the therapeutic efficacy and mechanism of OGB in modulating osteoclastic bone resorption remain undefined...
March 21, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38521428/the-effect-of-argania-spinosa-seed-oil-on-diabetic-nephropathy-in-streptozotocin-induced-diabetes-in-wistar-rats
#18
JOURNAL ARTICLE
Nour Elhouda Daoudi, Soufiane El Assri, Mohammed Aziz, Mohammed Choukri, Hassane Mekhfi, Abdelkhaleq Legssyer, Abderrahim Ziyyat, Mohamed Bnouham
ETHNOPHARMACOLOGICAL RELEVANCE: Diabetes is a significant metabolic disease impacting many of the world's population. In Morocco, a wide range of medicinal plants has taken great importance in the treatment of diabetes, among these plants; we find Argania spinosa (L.) Skeels. AIM: The objective of our work is based on the evaluation of the effect of roasted (Roil) and unroasted (UnRoil) Argan seed oil on diabetic nephropathy. MATERIALS AND METHODS: Roasted and unroasted oils from Argania spinosa (L...
March 21, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38521427/mechanism-of-tianma-gouteng-granules-lowering-blood-pressure-based-on-the-bile-acid-regulated-farnesoid-x-receptor-fibroblast-growth-factor-15-cholesterol-7%C3%AE-hydroxylase-pathway
#19
JOURNAL ARTICLE
Jianjun Yu, Qing Zhu, Maofu Zhou, Xiaofang Huang, Yimin Le, Hui Ouyang, Shaomin Cheng
ETHNOPHARMACOLOGICAL RELEVANCE: Tianma-Gouteng granules (TGG) is a traditional Chinese medicine compound that was first recorded by modern medical practitioner Hu Guangci in "New Meaning of the Treatment of Miscellaneous Diseases in Traditional Chinese Medicine". It is widely used to treat hypertensive vertigo, headache and insomnia. AIM OF STUDY: To investigate the antihypertensive effect of TGG and explore its mechanism. MATERIALS AND METHODS: Spontaneously hypertensive rats (SHR) were prepared a model of the ascendant hyperactivity of liver yang syndrome (AHLYS), blood pressure and general state of rats were recorded...
March 21, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38521426/astragaloside-iv-ameliorates-cisplatin-induced-liver-injury-by-modulating-ferroptosis-dependent-pathways
#20
JOURNAL ARTICLE
Jianan Guo, Yifei Le, Aini Yuan, Jing Liu, Hang Chen, Jiannan Qiu, Cui Wang, Xiaobing Dou, Xingyu Yuan, Dezhao Lu
ETHNOPHARMACOLOGICAL RELEVANCE: The use of antineoplastic drugs, such as cisplatin, in clinical practice can cause adverse effects in patients, such as liver injury, which limits their long-term use. Therefore, there is an urgent need to develop alternative therapeutic strategies or drugs to minimize cisplatin-induced liver injury. Huangqi, the root of Astragalus membranaceus, is extensively used in traditional Chinese medicine (TCM) and has been employed in treating diverse liver injuries...
March 21, 2024: Journal of Ethnopharmacology
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