Iram Shazia Tyagi, Ho Yin Calvin Tsui, Si Chen, Xinyi Li, Wai-Kin Mat, Muhammad A Khan, Lucas Brendan Choy, Ka-Yin Aden Chan, Tat-Ming Danny Chan, Chi-Ping Stephanie Ng, Ho-Keung Ng, Wai Sang Poon, Hong Xue
INTRODUCTION: Anti-mitosis has been a key strategy of anti-cancer therapies, targeting at a fundamental property of cancer cells, their non-controllable proliferation due to overactive mitotic divisions. For improved anti-cancer therapies, it is important to find out whether cancer cells can proliferate independent of mitosis and become resistant to anti-mitotic agents. RESULTS: In this study, live-cell imaging was applied to both primary-cultures of tumor cells, and immortalized cancer cell lines, to detect aberrant proliferations...
February 10, 2024: Cell Division