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https://www.readbyqxmd.com/read/29899525/genome-wide-association-study-of-habitual-physical-activity-in-over-377-000-uk-biobank-participants-identifies-multiple-variants-including-cadm2-and-apoe
#1
Yann C Klimentidis, David A Raichlen, Jennifer Bea, David O Garcia, Nathan E Wineinger, Lawrence J Mandarino, Gene E Alexander, Zhao Chen, Scott B Going
BACKGROUND/OBJECTIVES: Physical activity (PA) protects against a wide range of diseases. Habitual PA appears to be heritable, motivating the search for specific genetic variants that may inform efforts to promote PA and target the best type of PA for each individual. SUBJECTS/METHODS: We used data from the UK Biobank to perform the largest genome-wide association study of PA to date, using three measures based on self-report (nmax  = 377,234) and two measures based on wrist-worn accelerometry data (nmax  = 91,084)...
June 13, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29887161/lrp10-genetic-variants-in-familial-parkinson-s-disease-and-dementia-with-lewy-bodies-a-genome-wide-linkage-and-sequencing-study
#2
Marialuisa Quadri, Wim Mandemakers, Martyna M Grochowska, Roy Masius, Hanneke Geut, Edito Fabrizio, Guido J Breedveld, Demy Kuipers, Michelle Minneboo, Leonie J M Vergouw, Ana Carreras Mascaro, Ekaterina Yonova-Doing, Erik Simons, Tianna Zhao, Alessio B Di Fonzo, Hsiu-Chen Chang, Piero Parchi, Marta Melis, Leonor Correia Guedes, Chiara Criscuolo, Astrid Thomas, Rutger W W Brouwer, Daphne Heijsman, Angela M T Ingrassia, Giovanna Calandra Buonaura, Janneke P Rood, Sabina Capellari, Annemieke J Rozemuller, Marianna Sarchioto, Hsin Fen Chien, Nicola Vanacore, Simone Olgiati, Yah-Huei Wu-Chou, Tu-Hsueh Yeh, Agnita J W Boon, Susanne E Hoogers, Mehrnaz Ghazvini, Arne S IJpma, Wilfred F J van IJcken, Marco Onofrj, Paolo Barone, David J Nicholl, Andreas Puschmann, Michele De Mari, Anneke J Kievit, Egberto Barbosa, Giuseppe De Michele, Danielle Majoor-Krakauer, John C van Swieten, Frank J de Jong, Joaquim J Ferreira, Giovanni Cossu, Chin-Song Lu, Giuseppe Meco, Pietro Cortelli, Wilma D J van de Berg, Vincenzo Bonifati
BACKGROUND: Most patients with Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies do not carry mutations in known disease-causing genes. The aim of this study was to identify a novel gene implicated in the development of these disorders. METHODS: Our study was done in three stages. First, we did genome-wide linkage analysis of an Italian family with dominantly inherited Parkinson's disease to identify the disease locus. Second, we sequenced the candidate gene in an international multicentre series of unrelated probands who were diagnosed either clinically or pathologically with Parkinson's disease, Parkinson's disease dementia, or dementia with Lewy bodies...
June 6, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/29848412/aerobic-and-strength-training-exercise-programme-for-cognitive-impairment-in-people-with-mild-to-moderate-dementia-the-dapa-rct
#3
Sarah E Lamb, Dipesh Mistry, Sharisse Alleyne, Nicky Atherton, Deborah Brown, Bethan Copsey, Sukhdeep Dosanjh, Susanne Finnegan, Beth Fordham, Frances Griffiths, Susie Hennings, Iftekhar Khan, Kamran Khan, Ranjit Lall, Samantha Lyle, Vivien Nichols, Stavros Petrou, Peter Zeh, Bart Sheehan
BACKGROUND: Approximately 670,000 people in the UK have dementia. Previous literature suggests that physical exercise could slow dementia symptom progression. OBJECTIVES: To estimate the clinical effectiveness and cost-effectiveness of a bespoke exercise programme, in addition to usual care, on the cognitive impairment (primary outcome), function and health-related quality of life (HRQoL) of people with mild to moderate dementia (MMD) and carer burden and HRQoL...
May 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29777097/gwas-on-family-history-of-alzheimer-s-disease
#4
Riccardo E Marioni, Sarah E Harris, Qian Zhang, Allan F McRae, Saskia P Hagenaars, W David Hill, Gail Davies, Craig W Ritchie, Catharine R Gale, John M Starr, Alison M Goate, David J Porteous, Jian Yang, Kathryn L Evans, Ian J Deary, Naomi R Wray, Peter M Visscher
Alzheimer's disease (AD) is a public health priority for the 21st century. Risk reduction currently revolves around lifestyle changes with much research trying to elucidate the biological underpinnings. We show that self-report of parental history of Alzheimer's dementia for case ascertainment in a genome-wide association study of 314,278 participants from UK Biobank (27,696 maternal cases, 14,338 paternal cases) is a valid proxy for an AD genetic study. After meta-analysing with published consortium data (n = 74,046 with 25,580 cases across the discovery and replication analyses), three new AD-associated loci (P < 5 × 10-8 ) are identified...
May 18, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29776682/the-impact-of-apolipoprotein-e-alleles-on-cognitive-performance-in-patients-with-parkinson-s-disease
#5
Anna Pierzchlińska, Monika Białecka, Mateusz Kurzawski, Jarosław Sławek
Apolipoprotein E (ApoE) is a vital component of several lipoproteins and plays a major role in lipid metabolism. APOE gene comprises of three alleles determined by two single nucleotide polymorphisms (rs429358 and rs7412) resulting in the protein isoforms, among which ApoE4 is a confirmed risk factor for Alzheimer's Disease. However, the impact of APOE genotypes on Parkinson's Disease Dementia (PDD) is still inconclusive. The PDD diagnostic criteria are very inconsistent, and could be complemented with genetic factors...
May 5, 2018: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29752348/genetic-study-of-white-matter-integrity-in-uk-biobank-n-8448-and-the-overlap-with-stroke-depression-and-dementia
#6
Loes C A Rutten-Jacobs, Daniel J Tozer, Marco Duering, Rainer Malik, Martin Dichgans, Hugh S Markus, Matthew Traylor
BACKGROUND AND PURPOSE: Structural integrity of the white matter is a marker of cerebral small vessel disease, which is the major cause of vascular dementia and a quarter of all strokes. Genetic studies provide a way to obtain novel insights in the disease mechanism underlying cerebral small vessel disease. The aim was to identify common variants associated with microstructural integrity of the white matter and to elucidate the relationships of white matter structural integrity with stroke, major depressive disorder, and Alzheimer disease...
May 11, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29739127/diagnostic-validity-of-an-automated-probabilistic-tractography-in-amnestic-mild-cognitive-impairment
#7
Won Sang Jung, Yoo Hyun Um, Dong Woo Kang, Chang Uk Lee, Young Sup Woo, Won-Myong Bahk, Hyun Kook Lim
Objective: Although several prior works showed the white matter (WM) integrity changes in amnestic mild cognitive impairment (aMCI) and Alzheimer's disease, it is still unclear the diagnostic accuracy of the WM integrity measurements using diffusion tensor imaging (DTI) in discriminating aMCI from normal controls. The aim of this study is to explore diagnostic validity of whole brain automated probabilistic tractography in discriminating aMCI from normal controls. Methods: One hundred-two subjects (50 aMCI and 52 normal controls) were included and underwent DTI scans...
May 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29719518/body-mass-index-in-mild-cognitive-impairment-according-to-age-sex-cognitive-intervention-and-hypertension-and-risk-of-progression-to-alzheimer-s-disease
#8
Soo Hyun Joo, Se Hee Yun, Dong Woo Kang, Chang Tae Hahn, Hyun Kook Lim, Chang Uk Lee
Introduction: Mild cognitive impairment (MCI) is a prodromal stage of dementia. The association of body mass index (BMI) and progression to Alzheimer's disease (AD) in MCI subjects according to age, sex, and cognitive intervention remains unknown. We investigated the relationship between BMI and the risk of progression to AD in subjects with MCI, as well as the effect of BMI on progression to AD depending on age, sex, cognitive intervention, and chronic diseases. Methods: Three hundred and eighty-eight MCI subjects were followed for 36...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29669410/relationship-between-delusion-of-theft-and-cognitive-functions-in-patients-with-mild-alzheimer-s-disease
#9
Hae-Ran Na, Dong Woo Kang, Young-Sup Woo, Won-Myong Bahk, Chang-Uk Lee, Hyun Kook Lim
Although delusion of theft (DT) is the most frequent type of delusion in Alzheimer's disease (AD), its relationship to cognitive functions remains unclear. The aim of this study was to demonstrate the relationship between DT and cognitive functions in mild AD. Two hundred eighty-nine mild AD patients were enrolled in this study. These subjects were classified into three groups: patients with no delusions (ND, n=82), patients with paranoid delusions (PD, n=114) and patients with DT (n=93). Cognitive functions and their associations with the degree of delusion were compared among the three groups...
April 2018: Psychiatry Investigation
https://www.readbyqxmd.com/read/29621480/identifying-dementia-cases-with-routinely-collected-health-data-a-systematic-review
#10
Tim Wilkinson, Amanda Ly, Christian Schnier, Kristiina Rannikmäe, Kathryn Bush, Carol Brayne, Terence J Quinn, Cathie L M Sudlow
INTRODUCTION: Prospective, population-based studies can be rich resources for dementia research. Follow-up in many such studies is through linkage to routinely collected, coded health-care data sets. We evaluated the accuracy of these data sets for dementia case identification. METHODS: We systematically reviewed the literature for studies comparing dementia coding in routinely collected data sets to any expert-led reference standard. We recorded study characteristics and two accuracy measures-positive predictive value (PPV) and sensitivity...
April 3, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29596471/predicting-dementia-from-primary-care-records-a-systematic-review-and-meta-analysis
#11
Elizabeth Ford, Nicholas Greenslade, Priya Paudyal, Stephen Bremner, Helen E Smith, Sube Banerjee, Shanu Sadhwani, Philip Rooney, Seb Oliver, Jackie Cassell
INTRODUCTION: Possible dementia is usually identified in primary care by general practitioners (GPs) who refer to specialists for diagnosis. Only two-thirds of dementia cases are currently recorded in primary care, so increasing the proportion of cases diagnosed is a strategic priority for the UK and internationally. Variables in the primary care record may indicate risk of developing dementia, and could be combined in a predictive model to help find patients who are missing a diagnosis...
2018: PloS One
https://www.readbyqxmd.com/read/29567847/reliability-of-coded-data-to-identify-earliest-indications-of-cognitive-decline-cognitive-evaluation-and-alzheimer-s-disease-diagnosis-a-pilot-study-in-england
#12
Grazia Dell'Agnello, Urvi Desai, Noam Y Kirson, Jody Wen, Mark K Meiselbach, Catherine C Reed, Mark Belger, Alan Lenox-Smith, Carlos Martinez, Jill Rasmussen
OBJECTIVES: Evaluate the reliability of using diagnosis codes and prescription data to identify the timing of symptomatic onset, cognitive assessment and diagnosis of Alzheimer's disease (AD) among patients diagnosed with AD. METHODS: This was a retrospective cohort study using the UK Clinical Practice Research Datalink (CPRD). The study cohort consisted of a random sample of 50 patients with first AD diagnosis in 2010-2013. Additionally, patients were required to have a valid text-field code and a hospital episode or a referral in the 3 years before the first AD diagnosis...
March 22, 2018: BMJ Open
https://www.readbyqxmd.com/read/29538433/how-best-to-assess-quality-of-life-in-informal-carers-of-people-with-dementia-a-systematic-review-of-existing-outcome-measures
#13
Johanne Dow, Jonah Robinson, Shannon Robalino, Tracy Finch, Elaine McColl, Louise Robinson
BACKGROUND: In the UK, there are currently 800 000 people living with dementia. This number is expected to double in the next 20 years. Two-thirds of people with dementia live in the community supported by informal carers. Caring for a person with dementia has adverse effects on psychological, physical, social wellbeing and quality of life. The measurement of quality of life of carers of people with dementia is increasingly of interest to health and social care practitioners and commissioners, policymakers, and carers themselves...
2018: PloS One
https://www.readbyqxmd.com/read/29528031/how-do-doctors-deliver-a-diagnosis-of-dementia-in-memory-clinics
#14
Jemima Dooley, Nick Bass, Rose McCabe
BACKGROUND: Dementia diagnosis rates are increasing. Guidelines recommend that people with dementia should be told their diagnosis clearly and honestly to facilitate future planning. Aims To analyse how doctors deliver a dementia diagnosis in practice. METHOD: Conversation analysis was conducted on 81 video-recorded diagnosis feedback meetings with 20 doctors from nine UK memory clinics. RESULTS: All doctors named dementia; 59% (n = 48) approached the diagnosis indirectly but delicately ('this is dementia') and 41% (n = 33) approached this directly but bluntly ('you have Alzheimer's disease')...
April 2018: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/29482653/physical-activity-for-people-with-young-onset-dementia-and-carers-protocol-for-a-scoping-review
#15
Chloe Rodgers, David Rogerson, Judy Stevenson, Davina Porock
BACKGROUND: Physical activity has been cited as a potential symptomatic treatment option for people living with dementia. At present, much of the research concerning physical activity and dementia considers older adults, and there are several review articles summarising the evidence in this area. Less is known about physical activity for younger people with dementia, despite the marked differences in needs and preferences between the two groups. The aim of this scoping review is to systematically explore and critically appraise the current state of the evidence regarding physical activity for people with young-onset dementia and carers...
February 27, 2018: Systematic Reviews
https://www.readbyqxmd.com/read/29471784/potential-cost-savings-to-be-made-by-slowing-cognitive-decline-in-mild-alzheimer-s-disease-dementia-using-a-model-derived-from-the-uk-geras-observational-study
#16
Alan Lenox-Smith, Catherine Reed, Jeremie Lebrec, Mark Belger, Roy W Jones
BACKGROUND: Given the high costs associated with the care of those with Alzheimer's disease (AD) dementia, we examined the likely impact of a reduction in the rate of cognitive decline upon cost outcomes associated with this disease. METHODS: Using the group of patients with mild AD dementia from the GERAS study, generalised linear modelling (GLM) was used to explore the relationship between change in cognition as measured using the Mini-Mental State Examination (MMSE) and UK overall costs (health care and social care costs, and total societal costs) associated with AD dementia...
February 23, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29468724/a-roadmap-to-advance-dementia-research-in-prevention-diagnosis-intervention-and-care-by-2025
#17
James Pickett, Cathy Bird, Clive Ballard, Sube Banerjee, Carol Brayne, Katherine Cowan, Linda Clare, Adelina Comas-Herrera, Lynne Corner, Stephanie Daley, Martin Knapp, Louise Lafortune, Gill Livingston, Jill Manthorpe, Natalie Marchant, Jo Moriarty, Louise Robinson, Clare van Lynden, Gill Windle, Bob Woods, Katherine Gray, Clare Walton
OBJECTIVE: National and global dementia plans have focused on the research ambition to develop a cure or disease-modifying therapy by 2025, with the initial focus on investment in drug discovery approaches. We set out to develop complementary research ambitions in the areas of prevention, diagnosis, intervention, and care and strategies for achieving them. METHODS: Alzheimer's Society facilitated a taskforce of leading UK clinicians and researchers in dementia, UK funders of dementia research, people with dementia, and carer representatives to develop, using iterative consensus methodology, goals and recommendations to advance dementia research...
February 22, 2018: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29456161/the-effect-of-lrrk2-mutations-on-the-cholinergic-system-in-manifest-and-premanifest-stages-of-parkinson-s-disease-a-cross-sectional-pet-study
#18
Shu-Ying Liu, Daryl J Wile, Jessie Fanglu Fu, Jason Valerio, Elham Shahinfard, Siobhan McCormick, Rostom Mabrouk, Nasim Vafai, Jess McKenzie, Nicole Neilson, Alexandra Perez-Soriano, Julieta E Arena, Mariya Cherkasova, Piu Chan, Jing Zhang, Cyrus P Zabetian, Jan O Aasly, Zbigniew K Wszolek, Martin J McKeown, Michael J Adam, Thomas J Ruth, Michael Schulzer, Vesna Sossi, A Jon Stoessl
BACKGROUND: Markers of neuroinflammation are increased in some patients with LRRK2 Parkinson's disease compared with individuals with idiopathic Parkinson's disease, suggesting possible differences in disease pathogenesis. Previous PET studies have suggested amplified dopamine turnover and preserved serotonergic innervation in LRRK2 mutation carriers. We postulated that patients with LRRK2 mutations might show abnormalities of central cholinergic activity, even before the diagnosis of Parkinson's disease...
April 2018: Lancet Neurology
https://www.readbyqxmd.com/read/29452684/evaluation-of-the-safety-tolerability-and-efficacy-of-pimavanserin-versus-placebo-in-patients-with-alzheimer-s-disease-psychosis-a-phase-2-randomised-placebo-controlled-double-blind-study
#19
Clive Ballard, Carol Banister, Zunera Khan, Jeffrey Cummings, George Demos, Bruce Coate, James M Youakim, Randall Owen, Srdjan Stankovic
BACKGROUND: Pimavanserin is a selective 5-HT2A receptor inverse agonist and antagonist approved in the USA for the treatment of hallucinations and delusions associated with Parkinson's disease psychosis. No safe or effective pharmacological treatment is approved for psychosis in patients with Alzheimer's disease. Therefore, we aimed to evaluate the safety, tolerability, and efficacy of pimavanserin versus placebo in patients with Alzheimer's disease psychosis. METHODS: We did a phase 2, randomised, double-blind, placebo-controlled, single-centre (with multiple affiliated nursing home sites across the UK) study...
March 2018: Lancet Neurology
https://www.readbyqxmd.com/read/29413314/accelerated-long-term-forgetting-in-presymptomatic-autosomal-dominant-alzheimer-s-disease-a-cross-sectional-study
#20
Philip S J Weston, Jennifer M Nicholas, Susie M D Henley, Yuying Liang, Kirsty Macpherson, Elizabeth Donnachie, Jonathan M Schott, Martin N Rossor, Sebastian J Crutch, Christopher R Butler, Adam Z Zeman, Nick C Fox
BACKGROUND: Tests sensitive to presymptomatic changes in Alzheimer's disease could be valuable for clinical trials. Accelerated long-term forgetting-during which memory impairment becomes apparent over longer periods than usually assessed, despite normal performance on standard cognitive testing-has been identified in other temporal lobe disorders. We assessed whether accelerated long-term forgetting is a feature of presymptomatic autosomal dominant (familial) Alzheimer's disease, and whether there is an association between accelerated long-term forgetting and early subjective memory changes...
February 2018: Lancet Neurology
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