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https://www.readbyqxmd.com/read/27887645/resource-utilisation-costs-and-clinical-outcomes-in-non-institutionalised-patients-with-alzheimer-s-disease-18-month-uk-results-from-the-geras-observational-study
#1
Alan Lenox-Smith, Catherine Reed, Jeremie Lebrec, Mark Belger, Roy W Jones
BACKGROUND: Alzheimer's disease (AD), the commonest cause of dementia, represents a significant cost to UK society. This analysis describes resource utilisation, costs and clinical outcomes in non-institutionalised patients with AD in the UK. METHODS: The GERAS prospective observational study assessed societal costs associated with AD for patients and caregivers over 18 months, stratified according to baseline disease severity (mild, moderate, or moderately severe/severe [MS/S])...
November 25, 2016: BMC Geriatrics
https://www.readbyqxmd.com/read/27851868/pharmacotherapies-for-sleep-disturbances-in-dementia
#2
REVIEW
Jenny McCleery, Daniel A Cohen, Ann L Sharpley
BACKGROUND: Sleep disturbances, including reduced nocturnal sleep time, sleep fragmentation, nocturnal wandering, and daytime sleepiness are common clinical problems in dementia, and are associated with significant caregiver distress, increased healthcare costs, and institutionalisation. Drug treatment is often sought to alleviate these problems, but there is significant uncertainty about the efficacy and adverse effects of the various hypnotic drugs in this vulnerable population. OBJECTIVES: To assess the effects, including common adverse effects, of any drug treatment versus placebo for sleep disorders in people with dementia, through identification and analysis of all relevant randomised controlled trials (RCTs)...
November 16, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27800007/comparison-of-dementia-recorded-in-routinely-collected-hospital-admission-data-in-england-with-dementia-recorded-in-primary-care
#3
Anna Brown, Oksana Kirichek, Angela Balkwill, Gillian Reeves, Valerie Beral, Cathie Sudlow, John Gallacher, Jane Green
BACKGROUND: Electronic linkage of UK cohorts to routinely collected National Health Service (NHS) records provides virtually complete follow-up for cause-specific hospital admissions and deaths. The reliability of dementia diagnoses recorded in NHS hospital data is not well documented. METHODS: For a sample of Million Women Study participants in England we compared dementia recorded in routinely collected NHS hospital data (Hospital Episode Statistics: HES) with dementia recorded in two separate sources of primary care information: a primary care database [Clinical Practice Research Datalink (CPRD), n = 340] and a survey of study participants' General Practitioners (GPs, n = 244)...
2016: Emerging Themes in Epidemiology
https://www.readbyqxmd.com/read/27777022/clinical-phenotype-and-genetic-associations-in-autosomal-dominant-familial-alzheimer-s-disease-a-case-series
#4
Natalie S Ryan, Jennifer M Nicholas, Philip S J Weston, Yuying Liang, Tammaryn Lashley, Rita Guerreiro, Gary Adamson, Janna Kenny, Jon Beck, Lucia Chavez-Gutierrez, Bart de Strooper, Tamas Revesz, Janice Holton, Simon Mead, Martin N Rossor, Nick C Fox
BACKGROUND: The causes of phenotypic heterogeneity in familial Alzheimer's disease with autosomal dominant inheritance are not well understood. We aimed to characterise clinical phenotypes and genetic associations with APP and PSEN1 mutations in symptomatic autosomal dominant familial Alzheimer's disease (ADAD). METHODS: We retrospectively analysed genotypic and phenotypic data (age at symptom onset, initial cognitive or behavioural symptoms, and presence of myoclonus, seizures, pyramidal signs, extrapyramidal signs, and cerebellar signs) from all individuals with ADAD due to APP or PSEN1 mutations seen at the Dementia Research Centre in London, UK...
October 21, 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27757917/magnetic-resonance-imaging-of-ferumoxytol-labeled-human-mesenchymal-stem-cells-in-the-mouse-brain
#5
Na Kyung Lee, Hyeong Seop Kim, Dongkyeom Yoo, Jung Won Hwang, Soo Jin Choi, Wonil Oh, Jong Wook Chang, Duk L Na
The success of stem cell therapy is highly dependent on accurate delivery of stem cells to the target site of interest. Possible ways to track the distribution of MSCs in vivo include the use of reporter genes or nanoparticles. The U.S. Food and Drug Administration (FDA) has approved ferumoxytol (Feraheme® [USA], Rienso® [UK]) as a treatment for iron deficiency anemia. Ferumoxytol is an ultrasmall superparamagnetic iron oxide nanoparticle (USPIO) that has recently been used to track the fate of transplanted cells using magnetic resonance imaging (MRI)...
October 18, 2016: Stem Cell Reviews
https://www.readbyqxmd.com/read/27753980/pl-02-2-perspective-on-elderly-hypertension-in-asia
#6
Yoshihiro Kokubo
Hypertension is one of the strongest risk factor for cardiovascular disease. Recently, accumulating evidence also indicates that hypertension has been linked with non-cardiovascular diseases including dementia, cancer, oral health diseases and so on. In general, elderly individuals tend to have multiple diseases as getting older. Preventing of hypertension is also benefit for other diseases.In the Hisayama Study, hypertension increased the risk of vascular dementia, but were not associated with an increased risk of Alzheimer disease, and that subjects with hypertension in midlife and normotension and hypertension in late-life increased risks of incident vascular dementia...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27662321/alzheimer-s-disease-severity-is-not-significantly-associated-with-short-sleep-survey-by-actigraphy-on-208-mild-and-moderate-alzheimer-s-disease-patients
#7
Damien Leger, Maxime Elbaz, Alexandre Dubois, Stéphane Rio, Hocine Mezghiche, Paulo Carita, Jeanne Stemmelin, Melanie Strauss
BACKGROUND: In epidemiological surveys, cognitive decline has been found to be associated with both short and long sleep duration. OBJECTIVE: Our goal was to objectively determine how total sleep time (TST) at night was associated or not with apathy or severity scores in patients with Alzheimer 's disease (AD). METHODS: During an observational first step of a clinical trial, sleep was assessed in institutionalized patients with mild or moderate AD using actigraphy (MW8, Camtech, Cambridge, UK) for 14 consecutive 24-hour periods...
September 23, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27642891/pl-02-2-perspective-on-elderly-hypertension-in-asia
#8
Yoshihiro Kokubo
Hypertension is one of the strongest risk factor for cardiovascular disease. Recently, accumulating evidence also indicates that hypertension has been linked with non-cardiovascular diseases including dementia, cancer, oral health diseases and so on. In general, elderly individuals tend to have multiple diseases as getting older. Preventing of hypertension is also benefit for other diseases.In the Hisayama Study, hypertension increased the risk of vascular dementia, but were not associated with an increased risk of Alzheimer disease, and that subjects with hypertension in midlife and normotension and hypertension in late-life increased risks of incident vascular dementia...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27637430/clinical-impact-and-diagnostic-accuracy-of-2-18-f-fluoro-2-deoxy-d-glucose-positron-emission-tomography-computed-tomography-pet-ct-brain-imaging-in-patients-with-cognitive-impairment-a-tertiary-centre-experience-in-the-uk
#9
H Motara, T Olusoga, G Russell, S Jamieson, S Ahmed, N Brindle, A Pillai, A F Scarsbrook, C N Patel, F U Chowdhury
AIM: To evaluate the clinical impact of combined 2-[(18)F]-fluoro-2-deoxy-d-glucose (FDG) positron-emission tomography/computed tomography (PET/CT) brain imaging performed in selected patients with cognitive impairment at a tertiary referral centre in the UK, and to assess the accuracy of FDG PET/CT to correctly establish the diagnosis of Alzheimer's dementia (AD) in "real-world" clinical practice. METHODS AND MATERIALS: Using an institutional radiology database, 136 patients were identified for inclusion in the study...
September 13, 2016: Clinical Radiology
https://www.readbyqxmd.com/read/27630086/alzheimer-s-research-uk-2016-conference-report
#10
Rosa M Sancho, Carla J Cox, Laura E Phipps, Simon H Ridley
The annual Alzheimer's Research UK (ARUK) Conference was hosted by the Manchester and North West Network Centre on March 8-9, 2016. In this report, we provide a summary of the research presented.
2016: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/27507387/a-walk-through-dementia
#11
(no author information available yet)
Developed by charity Alzheimer's Research UK, and guided by people living with different forms of dementia, this app aims to give an insight into the everyday life of people suffering from dementia.
August 10, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27473843/towards-onset-prevention-of-cognition-decline-in-adults-with-down-syndrome-the-top-cog-study-a-pilot-randomised-controlled-trial
#12
Sally-Ann Cooper, Temitope Ademola, Muriel Caslake, Elizabeth Douglas, Jonathan Evans, Nicola Greenlaw, Caroline Haig, Angela Hassiotis, Andrew Jahoda, Alex McConnachie, Jill Morrison, Howard Ring, John Starr, Ciara Stiles, Chammy Sirisena, Frank Sullivan
BACKGROUND: Dementia is very common in Down syndrome (trisomy 21) adults. Statins may slow brain amyloid β (Aβ, coded on chromosome 21) deposition and, therefore, delay Alzheimer disease onset. One prospective cohort study with Down syndrome adults found participants on statins had reduced risk of incident dementia, but there are no randomised controlled trials (RCTs) on this issue. Evidence is sparse on the best instruments to detect longitudinal cognitive decline in older Down syndrome adults...
2016: Trials
https://www.readbyqxmd.com/read/27431327/a-comparison-of-health-utility-scores-calculated-using-united-kingdom-and-canadian-preference-weights-in-persons-with-alzheimer-s-disease-and-their-caregivers
#13
Mingying Fang, Mark Oremus, Jean-Eric Tarride, Parminder Raina
BACKGROUND: The use of the EQ-5D to asses the economic benefits of health technologies has led to questions about the cross-population transferability of preference weights to calculate health utility scores. The aim of this study is to investigate whether the use of UK and Canadian preference weights will lead to the calculation of different health utility scores in a sample of persons with Alzheimer's disease (AD) and their primary informal caregivers. METHODS: We recruited 216 patient-caregiver dyads from nine geriatric and memory clinics across Canada...
2016: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/27406118/dementia-friendly-communities-challenges-and-strategies-for-achieving-stakeholder-involvement
#14
Michelle Heward, Anthea Innes, Clare Cutler, Sarah Hambidge
Dementia-friendly communities (DFCs) are a UK policy initiative that aims to enable people with dementia to feel supported and included within their local community. Current approaches to DFC creation rely on stakeholder involvement, often requiring volunteer assistance. There is though a lack of evidence that examines the reality of achieving this. This paper critically assesses the challenges and strategies for achieving stakeholder involvement in DFCs. The evidence base is drawn from an inter-agency project funded by the National Health Service in the South of England where seven DFCs were developed by steering group partners and four part-time project workers (PWs)...
July 12, 2016: Health & Social Care in the Community
https://www.readbyqxmd.com/read/27258533/exercise-for-individuals-with-lewy-body-dementia-a-systematic-review
#15
Michael Inskip, Yorgi Mavros, Perminder S Sachdev, Maria A Fiatarone Singh
BACKGROUND: Individuals with Lewy body Dementia (LBD), which encompasses both Parkinson disease dementia (PDD) and Dementia with Lewy Bodies (DLB) experience functional decline through Parkinsonism and sedentariness exacerbated by motor, psychiatric and cognitive symptoms. Exercise may improve functional outcomes in Parkinson's disease (PD), and Alzheimer's disease (AD). However, the multi-domain nature of the LBD cluster of symptoms (physical, cognitive, psychiatric, autonomic) results in vulnerable individuals often being excluded from exercise studies evaluating physical function in PD or cognitive function in dementia to avoid confounding results...
2016: PloS One
https://www.readbyqxmd.com/read/27251676/utility-of-testing-for-apraxia-and-associated-features-in-dementia
#16
Samrah Ahmed, Ian Baker, Sian Thompson, Masud Husain, Christopher R Butler
INTRODUCTION: Existing literature suggests that the presence or absence of apraxia and associated parietal deficits may be clinically relevant in differential diagnosis of dementia syndromes. AIM: This study investigated the profile of these features in Alzheimer's disease (AD) and frontotemporal dementia (FTD) spectrum disorders, at first presentation. METHODS: Retrospective case note analysis was undertaken in 111 patients who presented to the Oxford Cognitive Disorders Clinic, Oxford, UK, including 29 amnestic AD, 12 posterior cortical atrophy (PCA), 12 logopenic primary progressive aphasia (lvPPA), 20 behavioural variant FTD (bvFTD), 7 non-fluent variant PPA (nfvPPA), 6 semantic variant PPA (svPPA) and 25 patients with subjective cognitive impairment (SCI)...
November 2016: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/27249223/influence-of-coding-variability-in-app-a%C3%AE-metabolism-genes-in-sporadic-alzheimer-s-disease
#17
Celeste Sassi, Perry G Ridge, Michael A Nalls, Raphael Gibbs, Jinhui Ding, Michelle K Lupton, Claire Troakes, Katie Lunnon, Safa Al-Sarraj, Kristelle S Brown, Christopher Medway, Jenny Lord, James Turton, Kevin Morgan, John F Powell, John S Kauwe, Carlos Cruchaga, Jose Bras, Alison M Goate, Andrew B Singleton, Rita Guerreiro, John Hardy
The cerebral deposition of Aβ42, a neurotoxic proteolytic derivate of amyloid precursor protein (APP), is a central event in Alzheimer's disease (AD)(Amyloid hypothesis). Given the key role of APP-Aβ metabolism in AD pathogenesis, we selected 29 genes involved in APP processing, Aβ degradation and clearance. We then used exome and genome sequencing to investigate the single independent (single-variant association test) and cumulative (gene-based association test) effect of coding variants in these genes as potential susceptibility factors for AD, in a cohort composed of 332 sporadic and mainly late-onset AD cases and 676 elderly controls from North America and the UK...
2016: PloS One
https://www.readbyqxmd.com/read/27167582/homocysteine-metabolism-and-the-associations-of-global-dna-methylation-with-selected-gene-polymorphisms-and-nutritional-factors-in-patients-with-dementia
#18
Małgorzata Bednarska-Makaruk, Ałła Graban, Agata Sobczyńska-Malefora, Dominic J Harrington, Michael Mitchell, Kieran Voong, Letian Dai, Wanda Łojkowska, Anna Bochyńska, Danuta Ryglewicz, Anna Wiśniewska, Hanna Wehr
Epigenetics (particularly DNA methylation) together with environmental and genetic factors, are key to understanding the pathogenesis of many diseases including dementia. Disturbances in DNA methylation have already been implicated in dementia. Homocysteine metabolism, with folate and vitamin B12 as essential cofactors, is integral to methylation processes. We evaluated in a case-control study the association of global DNA methylation, homocysteine, folate and vitamin B12 status with dementia. Selected polymorphisms of genes previously associated with dementia development and the influence of various factors on DNA methylation were also investigated...
August 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/27163798/excess-costs-associated-with-possible-misdiagnosis-of-alzheimer-s-disease-among-patients-with-vascular-dementia-in-a-uk-cprd-population
#19
Michael Happich, Noam Y Kirson, Urvi Desai, Sarah King, Howard G Birnbaum, Catherine Reed, Mark Belger, Alan Lenox-Smith, David Price
BACKGROUND: Prior diagnosis of Alzheimer's disease (AD) among patients later diagnosed with vascular dementia (VaD) has been associated with excess costs, suggesting potential benefits of earlier rule-out of AD diagnosis. OBJECTIVE: To investigate whether prior diagnosis with AD among patients with VaD is associated with excess costs in the UK. METHODS: Patients with a final VaD diagnosis, continuous data visibility for≥6 months prior to index date, and linkage to Hospital Episode Statistics data were retrospectively selected from de-identified Clinical Practice Research Datalink data...
May 6, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27142529/effect-of-diabetes-on-caregiver-burden-in-an-observational-study-of-individuals-with-alzheimer-s-disease
#20
MULTICENTER STUDY
Jeremie Lebrec, Haya Ascher-Svanum, Yun-Fei Chen, Catherine Reed, Kristin Kahle-Wrobleski, Ann Marie Hake, Joel Raskin, Ebrahim Naderali, Dara Schuster, Robert J Heine, David M Kendall
BACKGROUND: The burden on caregivers of patients with Alzheimer's disease (AD) is associated with the patient's functional status and may also be influenced by chronic comorbid medical conditions, such as diabetes. This post-hoc exploratory analysis assessed whether comorbid diabetes in patients with AD affects caregiver burden, and whether caregivers with diabetes experience greater burden than caregivers without diabetes. Caregiver and patient healthcare resource use (HCRU) were also assessed...
May 3, 2016: BMC Geriatrics
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