Junhan Zhang, Xiaona Na, Zhihui Li, John S Ji, Guowei Li, Haibing Yang, Yucheng Yang, Yuefeng Tan, Jian Zhang, Menglu Xi, Donghan Su, Huatang Zeng, Liqun Wu, Ai Zhao
BACKGROUND: Sarcopenic obesity, a clinical and functional condition characterized by the coexistence of obesity and sarcopenia, has not been investigated in relation to dementia risk and its onset. METHODS: We included 208,867 participants from UK biobank, who aged 60 to 69 years at baseline. Dementia diagnoses were identified using hospital records and death register data. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models to evaluate the associations of obesity, sarcopenia, and sarcopenic obesity with dementia risk, stratified by sex...
March 22, 2024: BMC Medicine