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https://www.readbyqxmd.com/read/28529332/adiposity-and-grip-strength-as-long-term-predictors-of-objectively-measured-physical-activity-in-93-015-adults-the-uk-biobank-study
#1
Y Kim, T White, K Wijndaele, S J Sharp, N J Wareham, S Brage
BACKGROUND/OBJECTIVES: Fatness and fitness are associated with physical activity (PA) but less is known about the prospective associations of adiposity and muscle strength with PA. This study aimed to determine longitudinal associations of body mass index (BMI), waist circumference (WC) and grip strength (GS) with objectively measured PA. SUBJECTS/METHODS: Data are from the UK Biobank study. At baseline (2006-2010), BMI, WC and GS were objectively measured. At follow-up (2013-2015), a sub-sample of 93 015 participants (52 161 women) wore a tri-axial accelerometer on the dominant wrist for 7 days...
May 22, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28528348/effect-of-home-noninvasive-ventilation-with-oxygen-therapy-vs-oxygen-therapy-alone-on-hospital-readmission-or-death-after-an-acute-copd-exacerbation-a-randomized-clinical-trial
#2
Patrick B Murphy, Sunita Rehal, Gill Arbane, Stephen Bourke, Peter M A Calverley, Angela M Crook, Lee Dowson, Nicholas Duffy, G John Gibson, Philip D Hughes, John R Hurst, Keir E Lewis, Rahul Mukherjee, Annabel Nickol, Nicholas Oscroft, Maxime Patout, Justin Pepperell, Ian Smith, John R Stradling, Jadwiga A Wedzicha, Michael I Polkey, Mark W Elliott, Nicholas Hart
Importance: Outcomes after exacerbations of chronic obstructive pulmonary disease (COPD) requiring acute noninvasive ventilation (NIV) are poor and there are few treatments to prevent hospital readmission and death. Objective: To investigate the effect of home NIV plus oxygen on time to readmission or death in patients with persistent hypercapnia after an acute COPD exacerbation. Design, Setting, and Participants: A randomized clinical trial of patients with persistent hypercapnia (Paco2 >53 mm Hg) 2 weeks to 4 weeks after resolution of respiratory acidemia, who were recruited from 13 UK centers between 2010 and 2015...
May 21, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28515950/factors-associated-with-poor-self-reported-health-within-the-uk-military-and-comparisons-with-the-general-population-a-cohort-study
#3
Sarah C Jenkins, Sharon Am Stevelink, Nicola T Fear
OBJECTIVE: To investigate the self-rated health of the UK military and explore factors associated with poor self-rated health. Compare self-rated health of the military to the general population. DESIGN: A cohort study. PARTICIPANTS: A total of 7626 serving and ex-serving UK military personnel, aged between 25 and 49; 19,452,300 civilians from England and Wales. SETTING: United Kingdom (military), England and Wales (civilians)...
May 2017: JRSM Open
https://www.readbyqxmd.com/read/28509510/editorial-selling-a-sugar-tax-the-sweet-smell-of-success
#4
Ffion Lloyd-Williams, Simon Capewell
This editorial briefly considers the increasing epidemic of obesity and Type 2 diabetes, the underlying drivers of junk food and sugary drinks, and the recent scientific and campaigning movements culminating in the UK Chancellor's surprise announcement of a Sugary Drinks Levy.
September 2016: Community Dental Health
https://www.readbyqxmd.com/read/28508896/obesity-related-cpg-methylation-cg07814318-of-kruppel-like-factor-13-klf13-gene-with-childhood-obesity-and-its-cis-methylation-quantitative-loci
#5
In-Uk Koh, Hye-Ja Lee, Joo-Yeon Hwang, Nak-Hyun Choi, Suman Lee
The cg07814318 hypermethylation of Kruppel-like factor 13 (KLF13) gene has been reported for its relevancy with Body Mass Index (BMI) from European origin. We explored the cg07814318 methylation and its cis-meQTL (cis-methylation quantitative loci) of KLF13 from a childhood obesity cohort. The cg07814318 methylation in blood was significantly associated with obesity and correlated with several obesity-related physical and biochemical traits. We examined the same loci from purified three human cell types (n = 47), i...
May 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28473168/periconception-mhealth-platform-for-prevention-of-placental-related-outcomes-and-non-communicable-diseases
#6
Régine P M Steegers-Theunissen
Most placental-related pregnancy complications originate during the first trimester of pregnancy where gene-environmental interactions play a role. The environmental factors also include parental behaviors that can be positive, such as folic acid supplement use, or negative, e.g. poor lifestyle choices like smoking, and nutritional choices that contribute to obesity or micronutrient deficits. The overlapping risk factors associated with non-communicable disease are poor nutrition, smoking, and obesity. These modifiable factors differ between individuals, populations and high, middle and low income countries, but have in common that they are extremely difficult to change...
April 23, 2017: Placenta
https://www.readbyqxmd.com/read/28465822/does-the-sex-of-one-s-co-twin-affect-height-and-bmi-in-adulthood-a-study-of-dizygotic-adult-twins-from-31-cohorts
#7
Leonie H Bogl, Aline Jelenkovic, Eero Vuoksimaa, Linda Ahrenfeldt, Kirsi H Pietiläinen, Maria A Stazi, Corrado Fagnani, Cristina D'Ippolito, Yoon-Mi Hur, Hoe-Uk Jeong, Judy L Silberg, Lindon J Eaves, Hermine H Maes, Gombojav Bayasgalan, Danshiitsoodol Narandalai, Tessa L Cutler, Christian Kandler, Kerry L Jang, Kaare Christensen, Axel Skytthe, Kirsten O Kyvik, Wendy Cozen, Amie E Hwang, Thomas M Mack, Catherine A Derom, Robert F Vlietinck, Tracy L Nelson, Keith E Whitfield, Robin P Corley, Brooke M Huibregtse, Tom A McAdams, Thalia C Eley, Alice M Gregory, Robert F Krueger, Matt McGue, Shandell Pahlen, Gonneke Willemsen, Meike Bartels, Toos C E M van Beijsterveldt, Zengchang Pang, Qihua Tan, Dongfeng Zhang, Nicholas G Martin, Sarah E Medland, Grant W Montgomery, Jacob V B Hjelmborg, Esther Rebato, Gary E Swan, Ruth Krasnow, Andreas Busjahn, Paul Lichtenstein, Sevgi Y Öncel, Fazil Aliev, Laura A Baker, Catherine Tuvblad, Sisira H Siribaddana, Matthew Hotopf, Athula Sumathipala, Fruhling Rijsdijk, Patrik K E Magnusson, Nancy L Pedersen, Anna K Dahl Aslan, Juan R Ordoñana, Juan F Sánchez-Romera, Lucia Colodro-Conde, Glen E Duncan, Dedra Buchwald, Adam D Tarnoki, David L Tarnoki, Yoshie Yokoyama, John L Hopper, Ruth J F Loos, Dorret I Boomsma, Thorkild I A Sørensen, Karri Silventoinen, Jaakko Kaprio
BACKGROUND: The comparison of traits in twins from opposite-sex (OS) and same-sex (SS) dizygotic twin pairs is considered a proxy measure of prenatal hormone exposure. To examine possible prenatal hormonal influences on anthropometric traits, we compared mean height, body mass index (BMI), and the prevalence of being overweight or obese between men and women from OS and SS dizygotic twin pairs. METHODS: The data were derived from the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) database, and included 68,494 SS and 53,808 OS dizygotic twin individuals above the age of 20 years from 31 twin cohorts representing 19 countries...
2017: Biology of Sex Differences
https://www.readbyqxmd.com/read/28454540/low-physical-activity-high-television-viewing-and-poor-sleep-duration-cluster-in-overweight-and-obese-adults-a-cross-sectional-study-of-398-984-participants-from-the-uk-biobank
#8
Sophie Cassidy, Josephine Y Chau, Michael Catt, Adrian Bauman, Michael I Trenell
BACKGROUND: An unhealthy lifestyle is one of the greatest contributors to obesity. A number of behaviours are linked with obesity, but are often measured separately. The UK Biobank cohort of >500,000 participants allows us to explore these behaviours simultaneously. We therefore aimed to compare physical activity, television (TV) viewing and sleep duration across body mass index (BMI) categories in a large sample of UK adults. METHODS: UK Biobank participants were recruited and baseline measures were taken between 2007 and 2010 and data analysis was performed in 2015...
April 28, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28440515/-interpretation-of-the-international-joint-statement-on-metabolic-surgery-in-the-treatment-algorithm-for-type-2-diabetes
#9
Peng Zhang, Chengzhu Zheng
Along with the soaring prevalence of obesity and type 2 diabetes mellitus (T2DM) globally, metabolic and bariatric surgery (MBS) has been rapidly developing into a major surgical subspecialty. However, the indications, benefits and potential risks of MBS are still controversial so far. In September 2015, the 2nd Diabetes Surgery Summit (DSS-II() was successfully convened, and later on an international joint statement on metabolic surgery in the treatment algorithm for T2DM was released based upon the consensus reached in DSS-II(, aiming to serve as a new global clinical guideline...
April 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28435162/self-regulation-and-household-routines-at-age-three-and-obesity-at-age-eleven-longitudinal-analysis-of-the-uk-millennium-cohort-study
#10
S E Anderson, A Sacker, R C Whitaker, Y Kelly
OBJECTIVE: To examine, in a population-based cohort of three-year-old children, the association between self-regulation and exposure to the household routines of regular bedtime, regular mealtime, and limits on watching television/video; and to determine whether self-regulation and these routines predict the risk of obesity at age 11. METHODS: Analyses included 10 955 children in the nationally-representative UK Millennium Cohort Study. When children were age 3, parents reported whether children had a regular bedtime and mealtime and the amount of television/video watched...
April 24, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28420322/epidemiology-of-paediatric-renal-stone-disease-a-22-year-single-centre-experience-in-the-uk
#11
Naomi Issler, Stephanie Dufek, Robert Kleta, Detlef Bockenhauer, Naima Smeulders, William Van't Hoff
BACKGROUND: Whilst still rare, the incidence of paediatric stone disease is increasing in developed countries and it is important to evaluate the aetiology. We set up a dedicated renal stone service for children combining medical and surgical expertise in 1993 and now have a large case series of children to investigate the epidemiology. METHODS: A retrospective hospital note review of children presenting with kidney stones during the last 22 years (1993-2015) was conducted...
April 18, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28399916/a-comparison-of-antenatal-classifications-of-overweight-and-obesity-prevalence-between-white-british-indian-pakistani-and-bangladeshi-pregnant-women-in-england-analysis-of-retrospective-data
#12
Rebecca Garcia, Nasreen Ali, Andy Guppy, Malcolm Griffiths, Gurch Randhawa
BACKGROUND: Maternal obesity increases women's risk of poor birth outcomes, and statistics show that Pakistani and Bangladeshi women (who are born or settled) in the UK experience higher rates of perinatal mortality and congenital anomalies than white British or white Other women. This study compares the prevalence of maternal obesity in Indian, Pakistani, Bangladeshi and white British women using standard and Asian-specific BMI metrics. METHOD: Retrospective cross-sectional analysis using routinely recorded secondary data in Ciconia Maternity information System (CMiS), between 2008 and 2013...
April 11, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28395937/risk-factors-for-diabetic-macular-oedema-in-type-2-diabetes-a-case-control-study-in-a-united-kingdom-primary-care-setting
#13
E Martín-Merino, J Fortuny, E Rivero-Ferrer, M Lind, L A Garcia-Rodriguez
AIM: To identify risk factors associated with the development of DMO among patients diagnosed with type 2 diabetes managed in a primary care setting in the UK. METHODS: A case-control study nested in a cohort of incident Type 2 diabetes identified in The Health Improvement Network database from 2000-2007. Cases were people with DMO (N=211) and controls were a DMO-free sample (N=2194). No age restrictions were applied. Adjusted odds ratios and 95%CIs were estimated (OR; 95%CI)...
June 2017: Primary Care Diabetes
https://www.readbyqxmd.com/read/28395588/health-promotion-in-medical-education-lessons-from-a-major-undergraduate-curriculum-implementation
#14
Ann Wylie, Kathleen Leedham-Green
Despite the economic, environmental and patient-related imperatives to prepare medical students to become health promoting doctors, health promotion remains relatively deprioritised in medical curricula. This paper uses an in-depth case study of a health promotion curriculum implementation at a large UK medical school to provide insights into the experiences of teachers and learners across a range of topics, pedagogies, and teaching & assessment modalities. Topics included smoking cessation, behavioural change approaches to obesity, exercise prescribing, social prescribing, maternal and child health, public and global health; with pedagogies ranging from e-learning to practice-based project work...
April 10, 2017: Education for Primary Care
https://www.readbyqxmd.com/read/28392996/body-mass-index-is-inversely-associated-with-mortality-in-patients-with-acute-kidney-injury-undergoing-continuous-renal-replacement-therapy
#15
Hyoungnae Kim, Joohwan Kim, Changhwan Seo, Misol Lee, Min-Uk Cha, Su-Young Jung, Jong Hyun Jhee, Seohyun Park, Hae-Ryong Yun, Youn Kyung Kee, Chang-Yun Yoon, Hyung Jung Oh, Jung Tak Park, Tae Ik Chang, Tae-Hyun Yoo, Shin-Wook Kang, Seung Hyeok Han
BACKGROUND: Many epidemiologic studies have reported on the controversial concept of the obesity paradox. The presence of acute kidney injury (AKI) can accelerate energy-consuming processes, particularly in patients requiring continuous renal replacement therapy (CRRT). Thus, we aimed to investigate whether obesity can provide a survival benefit in this highly catabolic condition. METHODS: We conducted an observational study in 212 patients who had undergone CRRT owing to various causes of AKI between 2010 and 2014...
March 2017: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/28384782/acceptance-of-surgical-treatment-for-adolescent-obesity-a-uk-perspective
#16
Simon Erridge, Swathikan Chidambaram, En Lin Goh
No abstract text is available yet for this article.
April 5, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28377390/translating-the-who-25%C3%A3-25-goals-into-a-uk-context-the-promise-modelling-study
#17
Linda J Cobiac, Peter Scarborough
OBJECTIVE: Model the impact of targets for obesity, diabetes, raised blood pressure, tobacco use, salt intake, physical inactivity and harmful alcohol use, as outlined in the Global Non-Communicable Disease Action Plan 2013-2020, on mortality and morbidity in the UK population. DESIGN: Dynamic population modelling study. SETTING: UK population. PARTICIPANTS: Not available. MAIN OUTCOME MEASURES: Mortality and morbidity (years lived with disability) from non-communicable diseases (NCDs) that are averted or delayed...
April 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28373160/genetic-analysis-of-venous-thromboembolism-in-uk-biobank-identifies-the-zfpm2-locus-and-implicates-obesity-as-a-causal-risk-factor
#18
Derek Klarin, Connor A Emdin, Pradeep Natarajan, Mark F Conrad, Sekar Kathiresan
BACKGROUND: UK Biobank is the world's largest repository for phenotypic and genotypic information for individuals of European ancestry. Here, we leverage UK Biobank to understand the inherited basis for venous thromboembolism (VTE), a leading cause of cardiovascular mortality. METHODS AND RESULTS: We identified 3290 VTE cases and 116 868 controls through billing code-based phenotyping. We performed a genome-wide association study for VTE with ≈9 000 000 imputed single-nucleotide polymorphisms...
April 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28371876/the-impact-of-greenspace-and-condition-of-the-neighbourhood-on-child-overweight
#19
Annemarie A H Schalkwijk, Babette C van der Zwaard, Giel Nijpels, Petra J M Elders, Lucinda Platt
Childhood overweight/obesity has been associated with environmental, parenting and socioeconomic status (SES) factors. This paper assesses the influence of the amount of green space, accessibility to a garden and neighbourhood condition on being overweight/obese. It investigates whether parental behaviours moderate or mediate this influence and evaluates the interaction of SES with environmental context. 6467 children from the UK Millennium Cohort Study living in England were analysed. We estimated logistic regressions to examine the initial association between environment and overweight...
March 21, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28371698/cardiovascular-causes-of-maternal-sudden-death-sudden-arrhythmic-death-syndrome-is-leading-cause-in-uk
#20
Dimitra Krexi, Mary N Sheppard
OBJECTIVE: This study aims to determine the causes of sudden cardiac death during pregnancy and in the postpartum period and patients' characteristics. There are few studies in the literature. METHODS: Eighty cases of sudden unexpected death due to cardiac causes in relation to pregnancy and postpartum period in a database of 4678 patients were found and examined macroscopically and microscopically. RESULTS: The mean age was 30±7 years with a range from 16 to 43 years...
May 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
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