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https://www.readbyqxmd.com/read/28736445/dietary-fat-and-total-energy-intake-modifies-the-effect-of-genetic-profile-risk-score-on-obesity-evidence-from-48-170-uk-biobank-participants
#1
C A Celis-Morales, D M Lyall, S Gray, L Steell, J Anderson, S Iliodromiti, P Welsh, Y Guo, F Petermann, D F Mackay, M E S Bailey, J Pell, J M R Gill, N Sattar
BACKGROUND: Obesity is a multifactorial condition influenced by both genetics and lifestyle. The aim of this study was to investigate whether the association between a validated genetic profile risk score for obesity (GPRS-obesity) and body mass index (BMI) or waist circumference (WC) was modified by macronutrient intake in a large general population study. METHODS: This study included cross-sectional data from 48 170 white European adults, aged 37-73 years, participating on the UK Biobank...
July 24, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28729327/dietary-intake-and-factors-influencing-eating-behaviours-in-overweight-and-obese-south-asian-men-living-in-the-uk-mixed-method-study
#2
Amir Emadian, Clare Y England, Janice L Thompson
OBJECTIVE: It is widely recognised that South Asian men living in the UK are more likely to develop type 2 diabetes mellitus (T2DM) than their white British counterparts. Despite this, limited data have been published quantifying current dietary intake patterns and qualitatively exploring eating behaviours in this population. The objectives of this study were to (1) assess diet, (2) explore perceptions of T2DM, (3) investigate factors influencing eating behaviours in overweight/obese South Asian men and (4) determine the suitability of the UK Diet and Diabetes Questionnaire (UKDDQ) for use in this population...
July 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28720270/cancer-through-black-eyes-the-views-of-uk-based-black-men-towards-cancer-a-constructivist-grounded-theory-study
#3
Betselot Mulugeta, Susan Williamson, Rob Monks, Thomas Hack, Kinta Beaver
PURPOSE: Little is known about black African (BA) and black African-Caribbean (BAC) men's views towards cancer; yet culture and acculturation can contribute to the way in which people understand, explain and develop their attitudes towards cancer. Hence, cancer prevention and early detection strategies may not be sensitive to United Kingdom (UK)-based black men's views, affecting their awareness of risk factors and early detection services. This study explored the views of UK-based BA and BAC men towards cancer...
August 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/28715498/growth-hormone-prescribing-and-initial-bmi-sds-increased-biochemical-adverse-effects-and-costs-in-obese-children-without-additional-gain-in-height
#4
Daniel B Hawcutt, Jennifer Bellis, Victoria Price, Anne Povall, Paul Newland, Paul Richardson, Matthew Peak, Jo Blair
BACKGROUND: Recombinant human growth hormone (rhGH) treatment in children is usually prescribed using actual body weight. This may result in inappropriately high doses in obese children. METHODS: Retrospective audit of all paediatric patients treated with rhGH 2010-14 at a tertiary paediatric hospital in the UK. Change in height SDS and IGF-I SDS during the first year of treatment was stratified by initial BMI SDS in a mixed cohort, and a subgroup of GH deficient (GHD) patients...
2017: PloS One
https://www.readbyqxmd.com/read/28714422/household-availability-of-ultra-processed-foods-and-obesity-in-nineteen-european-countries
#5
Carlos Augusto Monteiro, Jean-Claude Moubarac, Renata Bertazzi Levy, Daniela Silva Canella, Maria Laura da Costa Louzada, Geoffrey Cannon
OBJECTIVE: To assess household availability of NOVA food groups in nineteen European countries and to analyse the association between availability of ultra-processed foods and prevalence of obesity. DESIGN: Ecological, cross-sectional study. SETTING: Europe. SUBJECTS: Estimates of ultra-processed foods calculated from national household budget surveys conducted between 1991 and 2008. Estimates of obesity prevalence obtained from national surveys undertaken near the budget survey time...
July 17, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28711955/the-effect-of-early-feeding-practices-on-growth-indices-and-obesity-at-preschool-children-from-four-european-countries-and-uk-schoolchildren-and-adolescents
#6
George Moschonis, Blandine de Lauzon-Guillain, Louise Jones, Andreia Oliveira, Christina-Paulina Lambrinou, Louiza Damianidi, Sandrine Lioret, Pedro Moreira, Carla Lopes, Pauline Emmett, Marie Aline Charles, Yannis Manios
Not only healthy growth but also childhood obesity partly originate from early life. The current work aimed to examine the association of feeding practices during infancy with growth and adiposity indices in preschool children from four European countries and in UK schoolchildren and adolescents. Existing data from four European birth cohorts (ALSPAC-UK, EDEN-France, EuroPrevall-Greece and Generation XXI-Portugal) were used. Anthropometrics and body composition indices were collected. Parallel multivariate regression analyses were performed to examine the research hypothesis...
July 15, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28706535/which-factors-are-important-for-successful-sentinel-node-navigation-surgery-in-gastric-cancer-patients-analysis-from-the-senorita-prospective-multicenter-feasibility-quality-control-trial
#7
Ji Yeong An, Jae Seok Min, Young Joon Lee, Sang Ho Jeong, Hoon Hur, Sang Uk Han, Woo Jin Hyung, Gyu Seok Cho, Gui Ae Jeong, Oh Jeong, Young Kyu Park, Mi Ran Jung, Ji Yeon Park, Young Woo Kim, Hong Man Yoon, Bang Wool Eom, Keun Won Ryu
BACKGROUND: We investigated the results of quality control study prior to phase III trial of sentinel lymph node navigation surgery (SNNS). METHODS: Data were reviewed from 108 patients enrolled in the feasibility study of laparoscopic sentinel basin dissection (SBD) in gastric cancer. Seven steps contain tracer injection at submucosa (step 1) and at four sites (step 2) by intraoperative esophagogastroduodenoscopy (EGD), leakage of tracer (step 3), injection within 3 minutes (step 4), identification of at least one sentinel basin (SB) (step 5), evaluation of sentinel basin nodes (SBNs) by frozen biopsy (step 6), and identification of at least five SBNs at back table and frozen sections (step 7)...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28703939/adaptation-of-the-by-band-randomized-clinical-trial-to-by-band-sleeve-to-include-a-new-intervention-and-maintain-relevance-of-the-study-to-practice
#8
C A Rogers, B C Reeves, J Byrne, J L Donovan, G Mazza, S Paramasivan, R C Andrews, S Wordsworth, J Thompson, J M Blazeby, R Welbourn
BACKGROUND: Recruitment into surgical RCTs can be threatened if new interventions available outside the trial compete with those being evaluated. Adapting the trial to include the new intervention may overcome this issue, yet this is not often done in surgery. This paper describes the challenges, rationale and methods for adapting an RCT to include a new intervention. METHODS: The By-Band study was designed in the UK in 2009-2010 to compare the effectiveness of laparoscopic adjustable gastric band and Roux-en-Y gastric bypass for severe obesity...
August 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28701318/%C3%A2-liraglutide-for-weight-management
#9
(no author information available yet)
Since 1950, 25 anti-obesity drugs have been withdrawn from use across the world, largely as a result of adverse effects.(1) For several years, orlistat has been the only drug licensed in the UK for weight management.(2) In January 2017, a new presentation of the glucagon-like peptide-1 (GLP-1) analogue liraglutide (▾Saxenda - Novo Nordisk) was launched in the UK as an adjunct to a reduced-calorie diet and increased physical activity for weight management in adults. Here, we review the evidence for its efficacy and safety and consider its place in managing people who are overweight or obese...
July 2017: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/28698480/comparison-of-dietary-intakes-of-7-year-old-children-enrolled-in-observational-birth-cohort-studies-on-the-isle-of-man-and-in-south-west-england
#10
Ellen M Tweney, Pauline M Emmett, Jean Golding, Stephanie Goodfellow, Caroline M Taylor
There is concern regarding the amount of fruit and vegetables consumed and high sugar intakes in children's diets. Regional dietary differences in the British Isles could underlie variations in health outcomes, but little is known about these differences. Our aim was to compare diets of children enrolled in observational birth cohort studies in the Isle of Man (IoM-ELSPAC) and in south-west England (ALSPAC). Dietary intakes were assessed by 3-day food records in IoM and ALSPAC at an age of 7 years. Comparisons of mean daily nutrient, and food and food group intakes were made between the studies and with UK national dietary guidelines...
July 8, 2017: Nutrients
https://www.readbyqxmd.com/read/28695579/exploring-the-evidence-base-for-tier-3-weight-management-interventions-for-adults-a-systematic-review
#11
REVIEW
T J Brown, C O'Malley, J Blackshaw, V Coulton, A Tedstone, C Summerbell, L J Ells
Specialist weight management services provide a treatment option for severe obesity. The objective of the study is to review the characteristics, impact and practice implications of specialist weight management services for adults in the UK. Systematic review: EMBASE, MEDLINE and PsycINFO were searched from January 2005 to March 2016 with supplementary searches. Adults with a body mass index of ≥40 kg m(-2) , or ≥35 kg m(-2) with comorbidity or ≥30 kg m(-2) with type 2 diabetes and any study of multicomponent interventions, in any UK or Ireland setting, delivered by a specialist multidisciplinary team are the inclusion criteria...
July 10, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28693984/what-factors-influence-weight-loss-in-participants-of-commercial-weight-loss-programmes-implications-for-health-policy
#12
C D Madigan, A Roalfe, A J Daley, K Jolly
BACKGROUND: Finding effective referral policies for weight management services would have important public health implications. AIM: Here we compare percentage weight change by referral methods, BMI categories and participants who have had attended weight loss programmes multiple times. DESIGN AND SETTINGS: A prospective cohort study of 15,621 participants referred to 12-week behavioural weight loss programmes funded by the public health service in Birmingham, UK...
July 7, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28691137/effective-use-of-balloon-guide-catheters-in-reducing-incidence-of-mechanical-thrombectomy-related-distal-embolization
#13
Dong Hoon Lee, Jae Hoon Sung, Sang Uk Kim, Ho Jun Yi, Jae Taek Hong, Sang Won Lee
BACKGROUND AND PURPOSE: The clinical benefit of endovascular stroke therapy has been demonstrated in several prospective randomized trials. However, in a relevant percentage of patients, mechanical thrombectomy bears the risk of causing new infarction in initially unaffected vascular territories through thrombus fragmentation and migration of clot debris. The goal of this study was to evaluate the use of the balloon guide catheter (BGC) to effectively achieve flow arrest and thrombus aspiration during the intervention to avoid distal embolization...
July 9, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28687677/a-community-based-motivational-personalised-lifestyle-intervention-to-reduce-bmi-in-obese-adolescents-results-from-the-healthy-eating-and-lifestyle-programme-help-randomised-controlled-trial
#14
Deborah Christie, Lee Duncan Hudson, Sanjay Kinra, Ian Chi Kei Wong, Irwin Nazareth, Tim J Cole, Ulla Sovio, John Gregson, Anthony S Kessel, Anne Mathiot, Stephen Morris, Monica Panca, Silvia Costa, Rebecca Holt, Russell M Viner
OBJECTIVE: Approximately 7% of children and young people aged 5-15 years in the UK have obesity at a level likely to be associated with comorbidities. The majority of multicomponent lifestyle programmes have limited applicability and generalisability for British adolescents.The Healthy Eating and Lifestyle Programme (HELP) was a specific adolescent-focused intervention, designed for obese 12 to 18-year-olds seeking help to manage their weight. Participants were randomised to the 12-session HELP intervention or standard care...
July 7, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28684837/the-sugar-tax-an-opportunity-to-advance-oral-health
#15
V Wordley, H Lee, M Lomazzi, R Bedi
The new sugar tax was recently announced by Government, aiming to combat obesity through investment in school sports. Dental professionals should seize this rare opportunity to raise awareness of the other adverse effects of sugar; young children continue to suffer alarmingly high rates of dental cavities in the UK. A significant amount of money raised through the levy must be reinvested into ensuring fluoride toothpaste is more affordable. Since daily use of fluoride toothpaste is the most effective evidence-based oral health preventative measure that is widely used, this should receive tax exemption status from the government as a means of universal oral health prevention...
July 7, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28682127/factors-influencing-the-choice-of-treatment-modality-for-individual-patients-with-varicose-veins
#16
B Campbell, N Chinai, P Hollering, H Wright, R McCarthy
INTRODUCTION There is evidence of effectiveness for a range of different treatment modalities for varicose veins but limited information about factors that influence treatment choice for individual patients. METHODS A postal survey was sent to 438 UK members of the Vascular Society of Great Britain and Ireland. RESULTS Overall, 251 responses were received (response rate 57%). A total of 222 respondents treated varicose veins using conventional surgery (84%), endothermal ablation (82%) and foam sclerotherapy (68%)...
July 6, 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28680719/real-time-vessel-navigation-using-indocyanine-green-fluorescence-during-robotic-or-laparoscopic-gastrectomy-for-gastric-cancer
#17
Mina Kim, Sang-Yong Son, Long-Hai Cui, Ho-Jung Shin, Hoon Hur, Sang-Uk Han
PURPOSE: Identification of the infrapyloric artery (IPA) type is a key component of pylorus-preserving gastrectomy. As the indocyanine green (ICG) fluorescence technique is known to help visualize blood vessels and flow during reconstruction, we speculated that this emerging technique would be helpful in identifying the IPA type. MATERIALS AND METHODS: From August 2015 to February 2016, 20 patients who underwent robotic or laparoscopic gastrectomy were prospectively enrolled...
June 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/28679550/differences-in-genetic-and-environmental-variation-in-adult-body-mass-index-by-sex-age-time-period-and-region-an-individual-based-pooled-analysis-of-40-twin-cohorts
#18
Karri Silventoinen, Aline Jelenkovic, Reijo Sund, Yoshie Yokoyama, Yoon-Mi Hur, Wendy Cozen, Amie E Hwang, Thomas M Mack, Chika Honda, Fujio Inui, Yoshinori Iwatani, Mikio Watanabe, Rie Tomizawa, Kirsi H Pietiläinen, Aila Rissanen, Sisira H Siribaddana, Matthew Hotopf, Athula Sumathipala, Fruhling Rijsdijk, Qihua Tan, Dongfeng Zhang, Zengchang Pang, Maarit Piirtola, Sari Aaltonen, Sevgi Y Öncel, Fazil Aliev, Esther Rebato, Jacob B Hjelmborg, Kaare Christensen, Axel Skytthe, Kirsten O Kyvik, Judy L Silberg, Lindon J Eaves, Tessa L Cutler, Juan R Ordoñana, Juan F Sánchez-Romera, Lucia Colodro-Conde, Yun-Mi Song, Sarah Yang, Kayoung Lee, Carol E Franz, William S Kremen, Michael J Lyons, Andreas Busjahn, Tracy L Nelson, Keith E Whitfield, Christian Kandler, Kerry L Jang, Margaret Gatz, David A Butler, Maria A Stazi, Corrado Fagnani, Cristina D'Ippolito, Glen E Duncan, Dedra Buchwald, Nicholas G Martin, Sarah E Medland, Grant W Montgomery, Hoe-Uk Jeong, Gary E Swan, Ruth Krasnow, Patrik Ke Magnusson, Nancy L Pedersen, Anna K Dahl Aslan, Tom A McAdams, Thalia C Eley, Alice M Gregory, Per Tynelius, Laura A Baker, Catherine Tuvblad, Gombojav Bayasgalan, Danshiitsoodol Narandalai, Timothy D Spector, Massimo Mangino, Genevieve Lachance, S Alexandra Burt, Kelly L Klump, Jennifer R Harris, Ingunn Brandt, Thomas S Nilsen, Robert F Krueger, Matt McGue, Shandell Pahlen, Robin P Corley, Brooke M Huibregtse, Meike Bartels, Catharina Em van Beijsterveldt, Gonneke Willemsen, Jack H Goldberg, Finn Rasmussen, Adam D Tarnoki, David L Tarnoki, Catherine A Derom, Robert F Vlietinck, Ruth Jf Loos, John L Hopper, Joohon Sung, Hermine H Maes, Eric Turkheimer, Dorret I Boomsma, Thorkild Ia Sørensen, Jaakko Kaprio
Background: Genes and the environment contribute to variation in adult body mass index [BMI (in kg/m(2))], but factors modifying these variance components are poorly understood.Objective: We analyzed genetic and environmental variation in BMI between men and women from young adulthood to old age from the 1940s to the 2000s and between cultural-geographic regions representing high (North America and Australia), moderate (Europe), and low (East Asia) prevalence of obesity.Design: We used genetic structural equation modeling to analyze BMI in twins ≥20 y of age from 40 cohorts representing 20 countries (140,379 complete twin pairs)...
July 5, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28678979/association-of-body-mass-index-with-cardiometabolic-disease-in-the-uk-biobank-a-mendelian-randomization-study
#19
Donald M Lyall, Carlos Celis-Morales, Joey Ward, Stamatina Iliodromiti, Jana J Anderson, Jason M R Gill, Daniel J Smith, Uduakobong Efanga Ntuk, Daniel F Mackay, Michael V Holmes, Naveed Sattar, Jill P Pell
Importance: Higher body mass index (BMI) is a risk factor for cardiometabolic disease; however, the underlying causal associations remain unclear. Objectives: To use UK Biobank data to report causal estimates of the association between BMI and cardiometabolic disease outcomes and traits, such as pulse rate, using mendelian randomization. Design, Setting, and Participants: Cross-sectional baseline data from a population-based cohort study including 119 859 UK Biobank participants with complete phenotypic (medical and sociodemographic) and genetic data...
July 5, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28670116/treatment-trends-in-patients-with-asthma-copd-overlap-syndrome-in-a-copd-cohort-findings-from-a-real-world-survey
#20
Bo Ding, Mark Small
BACKGROUND: Asthma and chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) is an increasingly recognized phenotype. Few randomized clinical trials have been conducted in patients with ACOS; therefore, scientific evidence concerning ACOS is scarce and a therapeutic approach remains unclear. The aim of this study was to evaluate current treatment trends for patients with ACOS, identified as those with a dual definition of asthma and COPD, in a real-world COPD cohort. METHODS: Data were analyzed from patients with asthma and COPD in the USA, France, Germany, Italy, Spain, and the UK who participated in the 2012 and 2013 Adelphi Respiratory Disease Specific Programmes (DSPs)...
2017: International Journal of Chronic Obstructive Pulmonary Disease
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