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https://www.readbyqxmd.com/read/28212974/costs-and-outcomes-of-increasing-access-to-bariatric-surgery-cohort-study-and-cost-effectiveness-analysis-using-electronic-health-records
#1
Martin C Gulliford, Judith Charlton, Toby Prevost, Helen Booth, Alison Fildes, Mark Ashworth, Peter Littlejohns, Marcus Reddy, Omar Khan, Caroline Rudisill
OBJECTIVES: To estimate costs and outcomes of increasing access to bariatric surgery in obese adults and in population subgroups of age, sex, deprivation, comorbidity, and obesity category. METHODS: A cohort study was conducted using primary care electronic health records, with linked hospital utilization data, for 3,045 participants who underwent bariatric surgery and 247,537 participants who did not undergo bariatric surgery. Epidemiological analyses informed a probabilistic Markov model to compare bariatric surgery, including equal proportions with adjustable gastric banding, gastric bypass, and sleeve gastrectomy, with standard nonsurgical management of obesity...
January 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28211609/comparison-of-body-mass-index-at-diagnosis-of-diabetes-in-a-multiethnic-population-a-case-control-study-with-matched-non-diabetic-controls
#2
Sanjoy K Paul, Ebenezer S Owusu Adjah, Mayukh Samanta, Kiran Patel, Srikanth Bellary, Wasim Hanif, Kamlesh Khunti
AIMS: To investigate the probability of developing type 2 diabetes mellitus (T2DM) at different body mass index compared to matched non-diabetic controls in a multi-ethnic population. MATERIALS AND METHODS: Case-control study of 90,367 patients with incident diabetes and 362,548 age-sex-ethnicity matched controls from UK primary care. Probability of developing T2DM was estimated. RESULTS: Case and control patients were 56 years old at index and 56% were male...
February 17, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28194004/genetic-contributions-to-self-reported-tiredness
#3
V Deary, S P Hagenaars, S E Harris, W D Hill, G Davies, D C M Liewald, A M McIntosh, C R Gale, I J Deary
Self-reported tiredness and low energy, often called fatigue, are associated with poorer physical and mental health. Twin studies have indicated that this has a heritability between 6 and 50%. In the UK Biobank sample (N=108 976), we carried out a genome-wide association study (GWAS) of responses to the question, 'Over the last two weeks, how often have you felt tired or had little energy?' Univariate GCTA-GREML found that the proportion of variance explained by all common single-nucleotide polymorphisms for this tiredness question was 8...
February 14, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28186923/cross-sectional-survey-of-the-amount-of-free-sugars-and-calories-in-carbonated-sugar-sweetened-beverages-on-sale-in-the-uk
#4
Kawther M Hashem, Feng J He, Katharine H Jenner, Graham A MacGregor
OBJECTIVES: To investigate the free sugars and calorie content of carbonated sugar-sweetened beverages (CSSB) available in the main UK supermarkets. STUDY DESIGN: We carried out a cross-sectional survey in 2014 of 169 CSSB. METHODS: The free sugars (sugars g/100 mL) and calorie (kcal/100 mL) were collected from product packaging and nutrient information panels of CSSB available in 9 main UK supermarkets. RESULTS: The average free sugars content in CSSB was 30...
November 15, 2016: BMJ Open
https://www.readbyqxmd.com/read/28178349/correction-relationship-between-smoking-and-obesity-a-cross-sectional-study-of-499-504-middle-aged-adults-in-the-uk-general-population
#5
Shadrach Dare, Daniel F Mackay, Jill P Pell
[This corrects the article DOI: 10.1371/journal.pone.0123579.].
2017: PloS One
https://www.readbyqxmd.com/read/28176548/nutritional-adequacy-of-meals-from-an-independent-catering-facility-versus-chain-restaurants-for-young-adults
#6
Charoula Konstantia Nikolaou, Catherine Ruth Hankey, Michael Ernest John Lean
BACKGROUND/OBJECTIVES: Eating out of home has been associated with the increasing prevalence of obesity. While some chain restaurants provide nutritional information for their products, smaller independent catering facilities may not provide such information. The aim of this study was to assess the nutritional adequacy of meals provided to young adults at an independent catering facility and compare them with meals provided by chain restaurants. SUBJECTS/METHODS: Meals were analysed in 2014 in the UK in relation of nutrient provision to targets for macro- and micro-nutrients...
January 1, 2017: Nutrition and Health
https://www.readbyqxmd.com/read/28174667/evaluating-the-feasibility-of-a-web-based-weight-loss-programme-for-naval-service-personnel-with-excess-body-weight
#7
Gulcan Garip, Kate Morton, Robert Bridger, Lucy Yardley
BACKGROUND: Overweight and obesity are a major concern that may influence the operational capacity of the UK Naval Service (NS). This study was conducted to evaluate the feasibility of trialling and implementing a modified web-based weight loss programme for overweight and obese NS personnel. METHODS: The feasibility of a web-based weight loss programme with minimal face to face support was evaluated using a non-randomised design, based on the Reach, Efficacy, Adoption, and Implementation (RE-AIM) dimensions of a framework designed for analysing implementation of interventions in practice...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28166415/adverse-metabolic-and-mental-health-outcomes-associated-with-shiftwork-in-a-population-based-study-of-277-168-workers-in-uk-biobank
#8
Cathy A Wyse, Carlos A Celis Morales, Nicolas Graham, Yu Fan, Joey Ward, Anne M Curtis, Daniel Mackay, Daniel J Smith, Mark E S Bailey, Stephany Biello, Jason M R Gill, J P Pell
BACKGROUND: Reported associations between shiftwork and health have largely been based on occupation-specific, or single sex studies that might not be generalizable to the entire working population. The objective of this study was to investigate whether shiftwork was independently associated with obesity, diabetes, poor sleep and well-being in a large, UK general population cohort. METHODS: Participants of the UK Biobank study who were employed at the time of assessment were included...
February 6, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28166215/genetic-loci-associated-with-chronic-obstructive-pulmonary-disease-overlap-with-loci-for-lung-function-and-pulmonary-fibrosis
#9
Brian D Hobbs, Kim de Jong, Maxime Lamontagne, Yohan Bossé, Nick Shrine, María Soler Artigas, Louise V Wain, Ian P Hall, Victoria E Jackson, Annah B Wyss, Stephanie J London, Kari E North, Nora Franceschini, David P Strachan, Terri H Beaty, John E Hokanson, James D Crapo, Peter J Castaldi, Robert P Chase, Traci M Bartz, Susan R Heckbert, Bruce M Psaty, Sina A Gharib, Pieter Zanen, Jan W Lammers, Matthijs Oudkerk, H J Groen, Nicholas Locantore, Ruth Tal-Singer, Stephen I Rennard, Jørgen Vestbo, Wim Timens, Peter D Paré, Jeanne C Latourelle, Josée Dupuis, George T O'Connor, Jemma B Wilk, Woo Jin Kim, Mi Kyeong Lee, Yeon-Mok Oh, Judith M Vonk, Harry J de Koning, Shuguang Leng, Steven A Belinsky, Yohannes Tesfaigzi, Ani Manichaikul, Xin-Qun Wang, Stephen S Rich, R Graham Barr, David Sparrow, Augusto A Litonjua, Per Bakke, Amund Gulsvik, Lies Lahousse, Guy G Brusselle, Bruno H Stricker, André G Uitterlinden, Elizabeth J Ampleford, Eugene R Bleecker, Prescott G Woodruff, Deborah A Meyers, Dandi Qiao, David A Lomas, Jae-Joon Yim, Deog Kyeom Kim, Iwona Hawrylkiewicz, Pawel Sliwinski, Megan Hardin, Tasha E Fingerlin, David A Schwartz, Dirkje S Postma, William MacNee, Martin D Tobin, Edwin K Silverman, H Marike Boezen, Michael H Cho
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide. We performed a genetic association study in 15,256 cases and 47,936 controls, with replication of select top results (P < 5 × 10(-6)) in 9,498 cases and 9,748 controls. In the combined meta-analysis, we identified 22 loci associated at genome-wide significance, including 13 new associations with COPD. Nine of these 13 loci have been associated with lung function in general population samples, while 4 (EEFSEC, DSP, MTCL1, and SFTPD) are new...
February 6, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28122658/randomised-controlled-trial-and-economic-analysis-of-an-internet-based-weight-management-programme-power-positive-online-weight-reduction
#10
Paul Little, Beth Stuart, Fd Richard Hobbs, Jo Kelly, Emily R Smith, Katherine J Bradbury, Stephanie Hughes, Peter Wf Smith, Michael V Moore, Mike Ej Lean, Barrie M Margetts, Christopher D Byrne, Simon Griffin, Mina Davoudianfar, Julie Hooper, Guiqing Yao, Shihua Zhu, James Raftery, Lucy Yardley
BACKGROUND: Behavioural counselling with intensive follow-up for obesity is effective, but in resource-constrained primary care settings briefer approaches are needed. OBJECTIVES: To estimate the clinical effectiveness and cost-effectiveness of an internet-based behavioural intervention with regular face-to-face or remote support in primary care, compared with brief advice. DESIGN: Individually randomised three-arm parallel trial with health economic evaluation and nested qualitative interviews...
January 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28120239/the-impact-of-random-individual-differences-in-weight-change-on-the-measurable-objectives-of-lifestyle-weight-management-services
#11
Greg Atkinson, Alan M Batterham
Obese adults and children can be referred to lifestyle weight management services (LWMS) in which physical activity and/or dietary advice are delivered. Service providers quantify the 'weight' change between an initial measurement and follow-up measurement(s), which could be 12-24 months later. A control group is usually absent. The aim of this article is to scrutinise the various LWMS objectives for this weight change that are recommended by UK authorities. UK guidelines recommend that an adult LWMS should (A) reduce the sample mean body mass of all enrolled adults by at least 3% and/or (B) reduce the body mass of at least 30% of adults by at least 5%...
January 25, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28096974/mortality-hospital-days-and-treatment-costs-of-current-and-reduced-sugar-consumption-in-israel
#12
Gary M Ginsberg
BACKGROUND: Consumption of sugar causes tooth decay, overweight and obesity related morbidities. This paper in response to the Minister of Health's request, provides estimates of the mortality, morbidity and health care costs attributable to sugar consumption in Israel along with the effects of reducing sugar consumption. METHODS: Gender specific relative risks of many diseases from overweight (25 < =BMI < 30) and obesity (BMI > =30) were applied to the national gender specific prevalence rates of overweight and obesity in order to calculate the population attributable fraction (PAF) from overweight and obesity...
2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/28089924/water-juice-or-soda-mothers-and-grandmothers-of-preschoolers-discuss-the-acceptability-and-accessibility-of-beverages
#13
Karin Eli, Agneta Hörnell, Mahnoush Etminan Malek, Paulina Nowicka
Intake of sugary beverages is strongly associated with weight gain and obesity among children; however, differences between mothers' and grandmothers' attitudes and practices concerning young children's beverage consumption remain unclear. This is notable since about a quarter of families in the US and the UK rely on grandparents as the main providers of informal childcare. The aim of this study is to examine mothers' and maternal grandmothers' attitudes, knowledge, and practices regarding preschool aged children's beverage consumption...
January 12, 2017: Appetite
https://www.readbyqxmd.com/read/28077689/giant-cell-arteritis-and-vascular-disease-risk-factors-and-outcomes-a-cohort-study-using-uk-clinical-practice-research-datalink
#14
Lin Li, Tuhina Neogi, Susan Jick
OBJECTIVE: To evaluate the associations between GCA and vascular diseases and other comorbidities in patients with GCA compared with non-vasculitis patients. METHODS: Using the UK-based Clinical Practice Research Datalink we identified 9778 newly diagnosed GCA patients in 1990-2014, and up to 10 non-vasculitis patients randomly matched to each case on age, sex, practice and years of history before cohort entry. We compared the distributions of 9 different pre-existing vascular diseases and 11 other comorbidities, and risks of incident vascular diseases and other comorbidities after cohort entry between GCA and non-vasculitis patients...
January 11, 2017: Rheumatology
https://www.readbyqxmd.com/read/28077409/have-health-inequalities-changed-during-childhood-in-the-new-labour-generation-findings-from-the-uk-millennium-cohort-study
#15
Emeline Rougeaux, Steven Hope, Catherine Law, Anna Pearce
OBJECTIVES: To examine how population-level socioeconomic health inequalities developed during childhood, for children born at the turn of the 21st century and who grew up with major initiatives to tackle health inequalities (under the New Labour Government). SETTING: The UK. PARTICIPANTS: Singleton children in the Millennium Cohort Study at ages 3 (n=15 381), 5 (n=15 041), 7 (n=13 681) and 11 (n=13 112) years. PRIMARY OUTCOMES: Relative (prevalence ratios (PR)) and absolute health inequalities (prevalence differences (PD)) were estimated in longitudinal models by socioeconomic circumstances (SEC; using highest maternal academic attainment, ranging from 'no academic qualifications' to 'degree' (baseline))...
January 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28077364/socioeconomic-disadvantage-is-linked-to-obesity-across-generations-uk-study-finds
#16
Susan Mayor
No abstract text is available yet for this article.
January 10, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28073954/gene-obesogenic-environment-interactions-in-the-uk-biobank-study
#17
Jessica Tyrrell, Andrew R Wood, Ryan M Ames, Hanieh Yaghootkar, Robin N Beaumont, Samuel E Jones, Marcus A Tuke, Katherine S Ruth, Rachel M Freathy, George Davey Smith, Stéphane Joost, Idris Guessous, Anna Murray, David P Strachan, Zoltán Kutalik, Michael N Weedon, Timothy M Frayling
BACKGROUND: Previous studies have suggested that modern obesogenic environments accentuate the genetic risk of obesity. However, these studies have proven controversial as to which, if any, measures of the environment accentuate genetic susceptibility to high body mass index (BMI). METHODS: We used up to 120 000 adults from the UK Biobank study to test the hypothesis that high-risk obesogenic environments and behaviours accentuate genetic susceptibility to obesity...
January 10, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28073908/the-neuroendocrine-sequelae-of-paediatric-craniopharyngioma-a-40-year-meta-data-analysis-of-185-cases-from-three-uk-centres
#18
Timothy Shao Ern Tan, Leena Patel, Jaya Sujatha Gopal-Kothandapani, Sarah Ehtisham, Esieza Clare Ikazoboh, Richard Hayward, Kristian Aquilina, Mars Skae, Nicky Thorp, Barry Pizer, Mohammed Didi, Conor Mallucci, Joanne C Blair, Mark N Gaze, Ian Kamaly-Asl, Helen Spoudeas, Peter E Clayton
OBJECTIVES: The management of paediatric craniopharyngiomas was traditionally complete resection (CR), with better reported tumour control compared to that by partial resection (PR) or limited surgery (LS). The subsequent shift towards hypothalamic sparing, conservative surgery with adjuvant radiotherapy (RT) to any residual tumour aimed at reducing neuroendocrine morbidity, has not been systematically studied. Hence, we reviewed the sequelae of differing management strategies in paediatric craniopharyngioma across three UK tertiary centres over four decades...
March 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28059054/randomised-controlled-trial-evaluating-the-effectiveness-and-cost-effectiveness-of-families-for-health-a-family-based-childhood-obesity-treatment-intervention-delivered-in-a-community-setting-for-ages-6-to-11-years
#19
Wendy Robertson, Joanna Fleming, Atiya Kamal, Thomas Hamborg, Kamran A Khan, Frances Griffiths, Sarah Stewart-Brown, Nigel Stallard, Stavros Petrou, Douglas Simkiss, Elizabeth Harrison, Sung Wook Kim, Margaret Thorogood
BACKGROUND: Effective programmes to help children manage their weight are required. 'Families for Health' focuses on a parenting approach, designed to help parents develop their parenting skills to support lifestyle change within the family. Families for Health version 1 showed sustained reductions in mean body mass index (BMI) z-score after 2 years in a pilot project. OBJECTIVE: The aim was to evaluate its effectiveness and cost-effectiveness in a randomised controlled trial (RCT)...
January 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28057479/main-meal-quality-in-brazil-and-united-kingdom-similarities-and-differences
#20
Bartira Mendes Gorgulho, Gerda Karolien Pot, Flavia Mori Sarti, Dirce Maria Marchioni
Consumption of fast food and ready-to-eat meals has been positively associated with obesity. In the UK, ready-made meals are more often consumed than in Brazil, a country in which nutrition transition is relatively low. This study aimed to compare the nutritional quality of the main meal consumed by adults in Brazil and UK. Food record data was obtained from representative samples from UK and Brazil databases. The Main Meal Quality Index (MMQI) was applied to estimate the quality of the main meal consumed in Brazil and UK...
January 3, 2017: Appetite
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