Carla A Jaeger-Ruckstuhl, Yun Lo, Elena Fulton, Olivia G Waltner, Tamer B Shabaneh, Sylvain Simon, Pranav V Muthuraman, Colin E Correnti, Oliver J Newsom, Ian A Engstrom, Sami B Kanaan, Shruti S Bhise, Jobelle M C Peralta, Raymond Ruff, Jason P Price, Sylvia M Stull, Andrew R Stevens, Grace Bugos, Mitchell G Kluesner, Valentin Voillet, Vishaka Muhunthan, Fionnuala Morrish, James M Olson, Raphaël Gottardo, Jay F Sarthy, Steven Henikoff, Lucas B Sullivan, Scott N Furlan, Stanley R Riddell
The interaction of the tumor necrosis factor receptor (TNFR) family member CD27 on naive CD8+ T (Tn) cells with homotrimeric CD70 on antigen-presenting cells (APCs) is necessary for T cell memory fate determination. Here, we examined CD27 signaling during Tn cell activation and differentiation. In conjunction with T cell receptor (TCR) stimulation, ligation of CD27 by a synthetic trimeric CD70 ligand triggered CD27 internalization and degradation, suggesting active regulation of this signaling axis...
February 13, 2024: Immunity