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https://www.readbyqxmd.com/read/29670855/current-therapies-for-human-epidermal-growth-factor-receptor-2-positive-metastatic-breast-cancer-patients
#1
REVIEW
Alexey A Larionov
The median survival of patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (MBC) has more than doubled, since the discovery of HER2-targeted treatments: it rose from less than 2 years in 2001 (prior introduction of trastuzumab) to more than 4 years in 2017. The initial generation of HER2-targeted therapies included trastuzumab with taxanes in the first line, followed by the addition of lapatinib and by a switch to another cytotoxic agent after progression. Results of CLEOPATRA, EMILIA, and TH3RESA trials have changed this clinical practice...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29669730/drug-induced-alterations-of-mitochondrial-dna-homeostasis-in-steatotic-and-non-steatotic-heparg-cells
#2
Dounia Le Guillou, Simon Bucher, Karima Begriche, Delphine Hoet, Anne Lombes, Gilles Labbe, Bernard Fromenty
Although mitochondriotoxicity plays a major role in drug-induced hepatotoxicity, alteration of mitochondrial DNA (mtDNA) homeostasis has been described only with a few drugs. Because it requires long drug exposure, this mechanism of toxicity cannot be detected with investigations performed in isolated liver mitochondria or cultured cells exposed to drugs for several hours, or a few days. Thus, a first aim of this study was to determine whether a 2-week treatment with 9 hepatotoxic drugs could affect mtDNA homeostasis in HepaRG cells...
April 18, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29668215/limited-distribution-networks-stifle-competition-in-the-generic-and-biosimilar-drug-industries
#3
Laura Karas, Kenneth M Shermock, Celia Proctor, Mariana Socal, Gerard F Anderson
A limited distribution network (LDN) restricts the distribution channel for a pharmaceutical drug to 1 or a very small number of distributors. This strategy may allow for more effective allocation of drugs in shortage and is purported to help ensure the safe distribution of high-risk drugs to small patient populations. However, in recent years, some drug companies, including Turing Pharmaceuticals, have used LDNs to prevent generic and biosimilar companies from accessing samples of drug products necessary to perform testing required by the FDA for generic and biosimilar drug applications...
April 1, 2018: American Journal of Managed Care
https://www.readbyqxmd.com/read/29660875/metagenomic-analysis-of-antibiotic-resistance-genes-args-during-refuse-decomposition
#4
Xi Liu, Shu Yang, Yangqing Wang, He-Ping Zhao, Liyan Song
Landfill is important reservoirs of residual antibiotics and antibiotic resistance genes (ARGs), but the mechanism of landfill application influence on antibiotic resistance remains unclear. Although refuse decomposition plays a crucial role in landfill stabilization, its impact on the antibiotic resistance has not been well characterized. To better understand the impact, we studied the dynamics of ARGs and the bacterial community composition during refuse decomposition in a bench-scale bioreactor after long term operation (265d) based on metagenomics analysis...
April 12, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29658325/fabrication-of-a-drug-delivery-system-that-enhances-antifungal-drug-corneal-penetration
#5
Jingguo Li, Zhanrong Li, Zhen Liang, Lei Han, Huayang Feng, Siyu He, Junjie Zhang
Fungal keratitis (FK) remains a severe eye disease, and effective therapies are limited by drug shortages and critical ocular barriers. Despite the high antifungal potency and broad spectrum of econazole, its strong irritant and insolubility in water hinder its ocular application. We designed and fabricated a new drug delivery system based on a polymeric vector for the ocular antifungal application of econazole. This novel system integrates the advantages of its constituent units and exhibits superior comprehensive performance...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29622941/frustration-over-generic-drug-shortages-and-prices-prompts-federal-and-private-actions-health-systems-take-matters-into-their-own-hands
#6
Stephen Barlas
Generic shortages are draining hospital resources throughout the U.S. and in some cases imperiling inpatient treatment. The author considers the FDA's performance and describes the approach some health systems are taking to create a solution.
April 2018: P & T: a Peer-reviewed Journal for Formulary Management
https://www.readbyqxmd.com/read/29611482/potential-use-of-nanomedicine-for-the-anti-inflammatory-treatment-of-neurodegenerative-diseases
#7
Maria Dolores Cayero-Otero, Ana M Espinosa-Oliva, Antonio J Herrera, Irene Garcia-Dominguez, Mercedes Fernandez-Arevalo, Lucia Martin-Banderas, Rocio M de Pablos
Neurodegenerative diseases, like Alzheimer´s and Parkinson´s disease, are a group of disorders that have in common their increasingly high prevalence along with the shortage of effective treatments. In addition, the scientific community faces the challenge of getting the drugs used in these treatments to cross the blood-brain barrier (BBB) and reach the brain in sufficient concentration to be able to exert its effect. Hence, researchers across multiple disciplines are working together in order to improve the ability of therapeutics to penetrate the BBB...
April 2, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29610667/a-survey-of-knowledge-attitude-and-practices-of-private-retail-pharmacies-staff-in-tuberculosis-care-study-from-dera-ismail-khan-city-pakistan
#8
Tehmina Mustafa, Yasir Shahzad, Ayyaz Kiani
Background: In order to engage pharmacies in tuberculosis (TB) care, a survey was conducted in the Dera Ismail (DI) Khan City of the Khyber Pakhtoon Khwa province, Pakistan. The objectives were to; 1) characterize the retail pharmacies; 2) determine knowledge of the staff on various aspects of pulmonary TB; 3) determine practices related to the sale of anti-TB drugs, and referrals of presumptive TB patient, and willingness to participate in the National Tuberculosis Control Programme's (NTP) Directly Observed Treatment Short-Course (DOTS) strategy...
2018: Journal of Pharmaceutical Policy and Practice
https://www.readbyqxmd.com/read/29595964/in-situ-cellular-glycan-analysis
#9
Yunlong Chen, Lin Ding, Huangxian Ju
Glycan decorates all mammalian cell surfaces through glycosylation, which is one of the most important post-modifications of proteins. Glycans mediate a wide variety of biological processes, including cell growth and differentiation, cell-cell communication, immune response, pathogen interaction, and intracellular signaling events. Besides, tumor cells aberrantly express distinct sets of glycans, which can indicate different tumor onsets and progression processes. Thus, analysis of cellular glycans may contribute to understanding of glycan-related biological processes and correlation of glycan patterns with disease states for clinical diagnosis and treatment...
March 29, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29592767/drug-shortages-in-a-pediatric-stem-cell-transplantation-ward-challenges-and-implications-a-5-year-bilan
#10
B Claus, T Bauters, G Laureys
This article describes the implications of shortages of pharmaceutical products used in conditioning and supportive care regimens of pediatric patients undergoing a hematopoietic stem cell transplantation in a tertiary care hospital. Between July 2011 and July 2016, a total of 84 individual shortages, affecting 22 different drugs (79.8% supportive care drugs; 20.2% chemotherapeutics) were detected with a mean duration of 85 days (SD 138) per individual drug shortage. Eighteen shortages were critical and very urgent...
January 1, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29590366/-drug-adherence-levels-are-falling-down-again-health-worker-perceptions-of-women-s-service-utilization-before-and-after-integration-of-hiv-aids-services-into-general-care-in-india
#11
Shrivridhi Shukla, Felix M Muchomba, Judith L M McCoyd
Integrated models of HIV/AIDS service delivery are believed to have advantages over stand-alone models of care from health planners' and providers' perspectives. Integration models differ, yet there is little information about the influence of differing models on workers' beliefs about models' efficacy. Here, we examine the effect of integration of HIV care into the general health system in India. In 2014, India replaced its stand-alone model of HIV service delivery-Community Care Centers (CCCs)-with a purported integrated model that delivers HIV medical services at general hospitals and HIV psychosocial services at nearby Care and Support Centers (CSCs)...
March 26, 2018: Health Policy and Planning
https://www.readbyqxmd.com/read/29570363/pharmacist-views-on-alternative-methods-for-antiviral-distribution-and-dispensing-during-an-influenza-pandemic
#12
Gillian K SteelFisher, John M Benson, Hannah Caporello, Lisa M Koonin, Anita Patel, Eran Ben-Porath, Robert J Blendon
Antiviral drugs are likely to be a frontline countermeasure needed to minimize disease impact during an influenza pandemic. As part of pandemic influenza preparedness efforts, the Centers for Disease Control and Prevention, in coordination with state health departments, has plans in place to distribute and dispense antiviral drugs from public stockpiles. These plans are currently under review and include evaluation of the benefits of commercial distribution and dispensing through community pharmacies. To ensure this alternative distribution and dispensing system is viable, it is critical to assess pharmacist acceptability and to understand the pharmacist perspective on dispensing these antivirals during a response...
March 23, 2018: Health Security
https://www.readbyqxmd.com/read/29555641/affordability-and-availability-of-off-patent-drugs-in-the-united-states-the-case-for-importing-from-abroad-observational-study
#13
Ravi Gupta, Thomas J Bollyky, Matthew Cohen, Joseph S Ross, Aaron S Kesselheim
OBJECTIVES: To evaluate whether off-patent prescription drugs at risk of sudden price increases or shortages in the United States are available from independent manufacturers approved in other well regulated settings around the world. DESIGN: Observational study. SETTING: Off-patent drugs in the USA and approved by the Food and Drug Administration, up to 10 April 2017. STUDY COHORT: Novel tablet or capsule prescription drugs approved by the FDA since 1939 that were no longer protected by patents or other market exclusivity and had up to three generic versions...
March 19, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29555106/pharmacists-interventions-on-prescription-problems-in-one-french-community-pharmacy-a-prospective-pilot-study
#14
A Castronovo, F Gervais, C Mongaret, F Slimano
OBJECTIVES: While many international studies widely describe pharmacists' interventions (PIs) on drug-related problems (DRP) in community pharmacies, in France, these activities are underreported. The aim of this study is to describe the PI rate, given as the number of interventions in among all prescriptions reviewed during the study period. MATERIAL AND METHODS: This study was conducted in one French rural community pharmacy during a 7-month period. Age, sex, type of prescriber, type of problems, intervention and the outcome were prospectively recorded...
March 16, 2018: Annales Pharmaceutiques Françaises
https://www.readbyqxmd.com/read/29547426/improving-anesthesia-safety-in-low-resource-settings
#15
Fauzia A Khan, Alan F Merry
The safety of anesthesia characteristic of high-income countries today is not matched in low-resource settings with poor infrastructure, shortages of anesthesia providers, essential drugs, equipment, and supplies. Health care is delivered through complex systems. Achieving sustainable widespread improvement globally will require an understanding of how to influence such systems. Health outcomes depend not only on a country's income, but also on how resources are allocated, and both vary substantially, between and within countries...
April 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29544583/bridging-the-gap-for-clinical-pharmacist-in-developing-countries-like-pakistan
#16
Ali Ahmed, Maria Tanveer, Adeel Siddiqui, Gul Majid Khan
Clinical pharmacists should be increasingly important members of the healthcare team in developing countries such as Pakistan. Survey of literature was conducted to identify the determinants of clinical pharmacy in Pakistan. Lack of trained human capital, shortage of resources, patient overburden, inefficient pharmacy education curriculum, and limited job opportunities are some of the determinants of clinical pharmacy profession in developing countries. The underutilization of clinical pharmacists paves the way for an increased incidence of medication errors, adverse drug events, irrational prescribing, and suboptimal therapeutic outcomes...
March 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29536627/progress-in-scaffold-free-bioprinting-for-cardiovascular-medicine
#17
REVIEW
Nicanor I Moldovan
Biofabrication of tissue analogues is aspiring to become a disruptive technology capable to solve standing biomedical problems, from generation of improved tissue models for drug testing to alleviation of the shortage of organs for transplantation. Arguably, the most powerful tool of this revolution is bioprinting, understood as the assembling of cells with biomaterials in three-dimensional structures. It is less appreciated, however, that bioprinting is not a uniform methodology, but comprises a variety of approaches...
March 13, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29527345/can-lay-health-workers-support-the-management-of-hypertension-findings-of-a-cluster-randomised-trial-in-south-africa
#18
Jane Goudge, Tobias Chirwa, Sandra Eldridge, Francesc Xavier F Gómez-Olivé, Chodziwadziwa Kabudula, Felix Limbani, Eustasius Musenge, Margaret Thorogood
Introduction: In low/middle-income countries with substantial HIV and tuberculosis epidemics, health services often neglect other highly prevalent chronic conditions, such as hypertension, which as a result are poorly managed. This paper reports on a study to assess the effect on hypertension management of lay health workers (LHW) working in South African rural primary healthcare clinics to support the provision of integrated chronic care. Methods: A pragmatic cluster randomised trial with a process evaluation in eight rural clinics assessed the effect of adding two LHWs supporting nurses in providing chronic disease care in each intervention clinic over 18 months...
2018: BMJ Global Health
https://www.readbyqxmd.com/read/29523530/roundtable-report-takes-high-level-approach-to-drug-shortages
#19
Kate Traynor
No abstract text is available yet for this article.
March 15, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29481558/coverage-social-mobilization-and-challenges-of-mass-zithromax-administration-campaign-in-south-and-south-east-zones-of-tigray-northern-ethiopia-a-cross-sectional-study
#20
Afework Mulugeta, Gebremedhin Berhe Gebregergs, Selamawit Asfaw, Dejen Yemane, Mengistu Mitiku, Beyene Meresa, Goitom Gigar, Amanuel Kidane
BACKGROUND: The antibiotic treatment of people with trachoma helps to prevent transmission the disease in a community. Currently, Zithromax is the drug recommended for mass drug administration (MDA). MDA should be carried out annually for three to five years in trachoma endemic areas. Coverage survey is essential to track progress towards program goals and to identify communities with poor coverage in order to permit timely and appropriate actions. We assessed mass Zithromax administration coverage, social mobilization and campaign challenges in south and southeast zones of Tigray, Ethiopia...
February 26, 2018: PLoS Neglected Tropical Diseases
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