Hari P R Mangunuru, Leila Terrab, Venumadhav Janganati, Nageswara Rao Kalikinidi, Srinivasarao Tenneti, Vasudevan Natarajan, Arun D R Shada, Santhosh Reddy Naini, Praveen Gajula, Daniel Lee, Lalith P Samankumara, Manasa Mamunooru, Aravindan Jayaraman, Rajkumar Lalji Sahani, Jinya Yin, Chathuranga C Hewa-Rahinduwage, Aravind Gangu, Anji Chen, Zhirui Wang, Bimbisar Desai, Tai Y Yue, Chaitanya S Wannere, Joseph D Armstrong, Kai O Donsbach, Gopal Sirasani, B Frank Gupton, Bo Qu, Chris H Senanayake
Herein, we disclose a facile synthetic strategy to access an important class of drug molecules that contain chiral 1,2-amino alcohol functionality utilizing highly effective ruthenium-catalyzed asymmetric transfer hydrogenation of unprotected α-ketoamines. Recently, the COVID-19 pandemic has caused a crisis of shortage of many important drugs, especially norepinephrine and epinephrine, for the treatment of anaphylaxis and hypotension because of the increased demand. Unfortunately, the existing technologies are not fulfilling the worldwide requirement due to the existing lengthy synthetic protocols that require additional protection and deprotection steps...
April 22, 2024: Journal of Organic Chemistry