keyword
https://read.qxmd.com/read/38532885/regulation-of-interstitial-fluid-flow-in-adventitia-along-vasculature-by-heartbeat-and-respiration
#21
JOURNAL ARTICLE
Hongyi Li, Bei Li, Wenqi Luo, Xi Qi, You Hao, Chaozhi Yang, Wenqing Li, Jiazheng Li, Zhen Hua, Tan Guo, Zhijian Zheng, Xue Yu, Lei Liu, Jianping Zhao, Tiantian Li, Dahai Huang, Jun Hu, Zongmin Li, Fang Wang, Hua Li, Chao Ma, Fusui Ji
Converging studies showed interstitial fluid (ISF) adjacent to blood vessels flows in adventitia along vasculature into heart and lungs. We aim to reveal circulatory pathways and regulatory mechanism of such adventitial ISF flow in rat model. By MRI, real-time fluorescent imaging, micro-CT, and histological analysis, ISF was found to flow in adventitial matrix surrounded by fascia and along systemic vessels into heart, then flow into lungs via pulmonary arteries and back to heart via pulmonary veins, which was neither perivascular tissues nor blood or lymphatic vessels...
April 19, 2024: IScience
https://read.qxmd.com/read/38532299/pre-morbid-sleep-disturbance-and-its-association-with-stroke-severity-results-from-the-international-interstroke-study
#22
JOURNAL ARTICLE
Christine E Mc Carthy, Salim Yusuf, Conor Judge, John Ferguson, Graeme J Hankey, Shahram Oveis Gharan, Albertino Damasceno, Helle Klingenberg Iversen, Annika Rosengren, Okechukwu Ogah, Luísa Avezum, Patricio Lopez-Jaramillo, Denis Xavier, Xingyu Wang, Sumathy Rangarajan, Martin J O'Donnell
BACKGROUND AND PURPOSE: Whilst sleep disturbances are associated with stroke, their association with stroke severity is less certain. In the INTERSTROKE study, the association of pre-morbid sleep disturbance with stroke severity and functional outcome following stroke was evaluated. METHODS: INTERSTROKE is an international case-control study of first acute stroke. This analysis included cases who completed a standardized questionnaire concerning nine symptoms of sleep disturbance (sleep onset latency, duration, quality, nocturnal awakening, napping duration, whether a nap was planned, snoring, snorting and breathing cessation) in the month prior to stroke (n = 2361)...
March 26, 2024: European Journal of Neurology
https://read.qxmd.com/read/38532277/pulmonary-diffusing-capacity-for-carbon-monoxide-and-nitric-oxide-after-covid-19-a-prospective-cohort-study-the-secure-study
#23
JOURNAL ARTICLE
Anna Agnes Lytzen, Thora Wesenberg Helt, Jan Christensen, Thomas Kromann Lund, Anna Kalhauge, Frederikke Falkencrone Rönsholt, Daria Podlekavera, Elisabeth Arndal, Anne-Mette Lebech, Birgitte Hanel, Terese L Katzenstein, Ronan M G Berg, Jann Mortensen
Many patients exhibit persistently reduced pulmonary diffusing capacity after coronavirus disease 2019 (COVID-19). In this study, dual test gas diffusing capacity for carbon monoxide and nitric oxide (DL,CO,NO ) metrics and their relationship to disease severity and physical performance were examined in patients who previously had COVID-19. An initial cohort of 148 patients diagnosed with COVID-19 of all severities between March 2020 and March 2021 had a DL,CO,NO measurement performed using the single-breath method at 5...
March 26, 2024: Experimental Physiology
https://read.qxmd.com/read/38532272/an-integrative-review-of-home-care-recommendations-for-women-after-caesarean-section
#24
REVIEW
Mwajuma Bakari Mdoe, Lilian Teddy Mselle, Stephen Mathew Kibusi
AIM: To describe home-based care and practices recommended for mothers after caesarean section (CS), existing in the literature. DESIGN: Systematic review. METHODS: This integrative literature review was conducted by using Google Scholar, PubMed and Hinari databases from its inception to June 2021. The search included research articles, protocols and guidelines that describe home care practice after CS and assessed for their quality. Synthesis of recommendations from the included literature was classified based on the type of study design, and the review was guided by methodology registered in Prospero (ID CRD42021276905)...
March 2024: Nursing Open
https://read.qxmd.com/read/38532121/symptom-burden-and-relief-in-palliative-care-units-of-german-comprehensive-cancer-center-and-other-hospitals
#25
JOURNAL ARTICLE
Julia Berendt, Sarah Brunner, Maria Heckel, Mitra Tewes, Christoph Ostgathe, Susanne Gahr
PURPOSE: The National Hospice and Palliative Registry contains patient data from German hospice and palliative care facilities about symptoms. The aim of the study at hand is to differentiate symptom burden of patients in palliative care units between Comprehensive Cancer Center (CCC) and other hospitals regarding symptom burden and relief of patients in palliative care units. METHODS: The registry analysis provided data of patients in palliative care units (2014-2018)...
March 27, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38532117/acute-sodium-bicarbonate-administration-improves-ventilatory-efficiency-in-experimental-respiratory-acidosis-clinical-implications
#26
JOURNAL ARTICLE
Horacio J Adrogué, Nicolaos E Madias
Administering sodium bicarbonate (NaHCO3 ) to patients with respiratory acidosis breathing spontaneously is contraindicated because it increases carbon dioxide load and depresses pulmonary ventilation. Nonetheless, several studies have reported salutary effects of NaHCO3 in patients with respiratory acidosis but the underlying mechanism remains uncertain. Considering that such reports have been ignored, we examined the ventilatory response of unanesthetized dogs with respiratory acidosis to hypertonic NaHCO3 infusion (1 N, 5 mmol/kg) and compared it with that of animals with normal acid-base status or one of the remaining acid-base disorders...
March 26, 2024: Pflügers Archiv: European Journal of Physiology
https://read.qxmd.com/read/38532105/perturbations-in-inflammatory-pathways-are-associated-with-shortness-of-breath-profiles-in-oncology-patients-receiving-chemotherapy
#27
JOURNAL ARTICLE
Joosun Shin, Christine Miaskowski, Melisa L Wong, Patsy Yates, Adam B Olshen, Ritu Roy, Vasuda Dokiparthi, Bruce Cooper, Steven Paul, Yvette P Conley, Jon D Levine, Marilyn J Hammer, Kord Kober
PURPOSE: One plausible mechanistic hypothesis is the potential contribution of inflammatory mechanisms to shortness of breath. This study was aimed to evaluate for associations between the occurrence of shortness of breath and perturbations in inflammatory pathways. METHODS: Patients with cancer reported the occurrence of shortness of breath six times over two cycles of chemotherapy. Latent class analysis was used to identify subgroups of patients with distinct shortness of breath occurrence profiles (i...
March 26, 2024: Supportive Care in Cancer
https://read.qxmd.com/read/38532056/inter-coat-protein-loading-of-active-ingredients-into-tobacco-mild-green-mosaic-virus-through-partial-dissociation-and-reassembly-of-the-virion
#28
JOURNAL ARTICLE
Ivonne González-Gamboa, Adam A Caparco, Justin McCaskill, Paulina Fuenlabrada-Velázquez, Samuel S Hays, Zhicheng Jin, Jesse V Jokerst, Jonathan K Pokorski, Nicole F Steinmetz
Chemical pesticide delivery is a fundamental aspect of agriculture. However, the extensive use of pesticides severely endangers the ecosystem because they accumulate on crops, in soil, as well as in drinking and groundwater. New frontiers in nano-engineering have opened the door for precision agriculture. We introduced Tobacco mild green mosaic virus (TMGMV) as a viable delivery platform with a high aspect ratio and favorable soil mobility. In this work, we assess the use of TMGMV as a chemical nanocarrier for agriculturally relevant cargo...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531748/development-of-a-machine-learning-model-for-prediction-of-the-duration-of-unassisted-spontaneous-breathing-in-patients-during-prolonged-weaning-from-mechanical-ventilation
#29
JOURNAL ARTICLE
Sebastian Johannes Fritsch, Morris Riedel, Gernot Marx, Johannes Bickenbach, Andreas Schuppert
PURPOSE: Treatment of patients undergoing prolonged weaning from mechanical ventilation includes repeated spontaneous breathing trials (SBTs) without respiratory support, whose duration must be balanced critically to prevent over- and underload of respiratory musculature. This study aimed to develop a machine learning model to predict the duration of unassisted spontaneous breathing. MATERIALS AND METHODS: Structured clinical data of patients from a specialized weaning unit were used to develop (1) a classifier model to qualitatively predict an increase of duration, (2) a regressor model to quantitatively predict the precise duration of SBTs on the next day, and (3) the duration difference between the current and following day...
March 26, 2024: Journal of Critical Care
https://read.qxmd.com/read/38531714/management-of-multiple-and-displaced-mandibular-fractures-in-a-pediatric-patient-sans-mandibular-immobilization-sans-open-reduction-and-internal-fixation
#30
Elavenil Panneerselvam, Chandini Ravikumar, Trishala Annamalai Rajan, Sasikala Balasubramanian, V B Krishnakumar Raja
Maxillofacial fractures in the pediatric population are generally managed by conservative approaches such as soft diet and medication or semi-invasive procedures namely inter-maxillary fixation or circum-mandibular wiring. These approaches are preferred over any invasive treatment to minimize injury to the growing skeleton and tooth germs. Displaced fractures that cause functional problems such as restricted mouth opening, malocclusion or impaired breathing, mandate open reduction and internal fixation. However, surgical management is associated with morbidity related to general anesthesia, risk of injury to vital structures, and potential, skeletal or dental growth disturbances...
March 8, 2024: Chinese Journal of Traumatology
https://read.qxmd.com/read/38531567/nomogram-for-predicting-moderate-to-severe-sleep-disordered-breathing-in-patients-with-acute-ischaemic-stroke-a-retrospective-cohort-study
#31
JOURNAL ARTICLE
Yang Gu, Junchao Xie, Xueyuan Liu, Xiaoyu Zhou
OBJECTIVES: Moderate-to-severe sleep-disordered breathing (SDB) is prevalent in patients with acute ischaemic stroke (AIS) and is associated with an increased risk of unfavourable prognosis. We aimed to develop and validate a reliable scoring system for the early screening of moderate-to-severe SDB in patients with AIS, with the objective of improving the management of those patients at risk. STUDY DESIGN: We developed and validated a nomogram model based on univariate and multivariate logistic analyses to identify moderate-to-severe SDB in AIS patients...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38531171/efficacy-and-safety-of-mesenchymal-stem-cell-derived-microvesicles-in-mouse-inflammatory-arthritis
#32
JOURNAL ARTICLE
Shixiong Wei, Chenyang Lu, Sujia Li, Qiuping Zhang, Ruijuan Cheng, ShuYue Pan, QiuHong Wu, Xueting Zhao, Xinping Tian, Xiaofeng Zeng, Yi Liu
OBJECTIVE: To determine the effective and safe intravenous doses of mesenchymal stem cells (MSCs)-derived microvesicles (MVs) and to elucidate the possible causes of death in mice receiving high-dose MVs. METHODS: MVs were isolated from human MSCs by gradient centrifugation. Mice with collagen-induced arthritis were treated with different doses of intravenous MVs or MSCs. Arthritis severity, white blood cell count, and serum C-reactive protein levels were measured...
March 25, 2024: International Immunopharmacology
https://read.qxmd.com/read/38530903/sequence-dependence-in-nucleosome-dynamics
#33
JOURNAL ARTICLE
Prabir Khatua, Phu K Tang, Abhik Ghosh Moulick, Rutika Patel, Anjela Manandhar, Sharon M Loverde
The basic packaging unit of eukaryotic chromatin is the nucleosome that contains 145-147 base pair duplex DNA wrapped around an octameric histone protein. While the DNA sequence plays a crucial role in controlling the positioning of the nucleosome, the molecular details behind the interplay between DNA sequence and nucleosome dynamics remain relatively unexplored. This study analyzes this interplay in detail by performing all-atom molecular dynamics simulations of nucleosomes, comparing the human α-satellite palindromic (ASP) and the strong positioning "Widom-601" DNA sequence at time scales of 12 μs...
March 26, 2024: Journal of Physical Chemistry. B
https://read.qxmd.com/read/38530178/case-323-minute-pulmonary-meningothelial-like-nodules
#34
JOURNAL ARTICLE
Furkan Ufuk, Emel Kilicarslan, Ferda Bir, Goksel Altinisik
A 70-year-old woman with a 6-year history of asthma, a 12-year history of diabetes mellitus, and who did not smoke presented to the pulmonology clinic with dyspnea and cough. Chest CT performed 5 years earlier for similar symptoms revealed multiple pulmonary nodules. However, she was lost to follow-up before the work-up was concluded. Otherwise, her medical history was unremarkable. Family history included maternal endometrial cancer. Physical examination revealed partial oxygen saturation of 98%, respiratory rate of 18 breaths per minute, and heart rate of 77 beats per minute...
March 2024: Radiology
https://read.qxmd.com/read/38530127/interoceptive-awareness-mediated-the-effects-of-a-15-minute-diaphragmatic-breathing-on-empathy-for-pain-a-randomized-controlled-trial
#35
JOURNAL ARTICLE
Yaping He, Likun Ge, Jiajin Yuan, Yingying Wang, Danni Zheng, An Rui, Jun Song, Li Hu, Gao-Xia Wei
Although empathy for pain plays an important role in positive interpersonal relationships and encourages engagement in prosocial behavior, it remains largely unknown whether empathy for pain could be effectively altered by psychophysiological techniques. This study aimed to investigate the impact of a single session of diaphragmatic breathing practice on empathy for pain and examine the potential mechanism involving interoceptive awareness. A total of 66 healthy participants were randomly assigned to the intervention group or the control group...
March 26, 2024: Psychophysiology
https://read.qxmd.com/read/38529426/pattern-of-antibiotic-use-among-children-with-acute-respiratory-infections-in-saudi-arabia-clinical-assessment
#36
JOURNAL ARTICLE
Nehal Mejze Jeza Alharbi, Noha Farouk Tashkandi, Asma Mohammad Banjar, Asmaa Yassir Alotaibi, Sarah Al-Harbi, Anas Mohammed Ahmed Alqarni, Younis Abdulrahman Alharbi, Haneen H Alkenani, Abdulraoof Abdulrhman Bokhari
OBJECTIVES: This study aimed to evaluate the common clinical diagnoses and treatment management of acute respiratory infections (ARIs) in children and determine when antibiotics are recommended and prescribed. METHODS: A retrospective review of medical charts was carried out at King Salman Bin Abdulaziz Medical City (KSAMC) Hospital to assess pediatric patients diagnosed with ARIs aged 0-14 years, excluding those requiring antibiotics for conditions other than ARIs...
February 2024: Curēus
https://read.qxmd.com/read/38529375/case-report-a-case-of-metastatic-brafv600-mutated-melanoma-with-heart-failure-treated-with-immune-checkpoint-inhibitors-and-braf-mek-inhibitors
#37
Aya Nishizawa, Misaki Kawakami, Yasuyuki Kitahara
BACKGROUND: Novel therapies, immune checkpoint inhibitors (ICIs), and BRAF/MEK inhibitors (BRAFi/MEKi) provide unprecedented survival benefits for patients with advanced melanoma. However, the management of drug-induced adverse events is problematic for both agents and, although rare, can cause serious cardiac dysfunction. CASE REPORT: A 42-year-old male patient with no significant medical history noticed a fading dark brown patch on his left anterior chest, which had been there for 20 years, after his second coronavirus disease 2019 (COVID-19) vaccination...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38529349/ers-international-congress-2023-highlights-from-the-sleep-disordered-breathing-assembly
#38
JOURNAL ARTICLE
Matteo Siciliano, Matteo Bradicich, Pasquale Tondo, Canan Gunduz Gurkan, Wojciech Kuczyński, Alessia Martini, Özge Aydin Güçlü, Dries Testelmans, Manuel Sánchez-de-la-Torre, Winfried Randerath, Esther Irene Schwarz, Sophia Schiza
The topic of sleep-related breathing disorders is always evolving, and during the European Respiratory Society (ERS) International Congress 2023 in Milan, Italy, the latest research and clinical topics in respiratory medicine were presented. The most interesting issues included new diagnostic tools, such as cardiovascular parameters and artificial intelligence, pathophysiological traits of sleep disordered breathing from routine polysomnography or polygraphy signals, and new biomarkers and the diagnostic approach in patients with excessive daytime sleepiness...
March 2024: ERJ Open Research
https://read.qxmd.com/read/38529319/extracorporeal-membrane-oxygenation-in-acute-respiratory-failure-due-to-hemorrhagic-alveolitis-in-a-patient-with-acute-myeloblastic-leukemia
#39
Martina Cuccarelli, Lorenzo Schiavoni, Felice Eugenio Agrò, Giuseppe Pascarella, Fabio Costa, Rita Cataldo, Massimiliano Carassiti, Alessia Mattei
Introduction . Extracorporeal membrane oxygenation (ECMO) support for severe acute respiratory distress syndrome (ARDS) is nowadays widely used with notable results on the overall survival as reported in the ELSO registry near to 55% at 90 days. This is the reason why ECMO teams force the use of this extreme technique to several populations, even though there is still a lack of data about its use on hematological patients. Case Report . A 39-year-old woman without a history of previous diseases, but a new diagnosis of acute myeloblastic leukemia (AML) was admitted to intensive care unit (ICU) for worsening hypoxia and respiratory acidosis, presenting an ARDS with PaO2 /FiO2 < 100 in spontaneous breathing treated with noninvasive ventilation via full-face mask...
2024: Case Reports in Critical Care
https://read.qxmd.com/read/38529098/recurrence-rate-and-influencing-factors-of-helicobacter-pylori-infection-after-successful-eradication-in-southern-coastal-china
#40
JOURNAL ARTICLE
Daya Zhang, Fengjiao Mao, Shimei Huang, Chen Chen, Da Li, Fan Zeng, Feihu Bai
PURPOSE: Recurrence rate of Helicobacter pylori ( H. pylori ) infection after successful eradication have gained attention. This study was to assess the recurrence rate of H. pylori infection after successful eradication in the southern coastal provinces of China and to analyze its factors. PATIENTS AND METHODS: 975 patients with upper gastrointestinal symptoms who were diagnosed with H. pylori infection using the 13C or 14C-urea breath test (UBT) underwent eradication treatment between August 2021 and December 2022...
2024: International Journal of General Medicine
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