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Staphylococcus aureus bacteremia

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https://www.readbyqxmd.com/read/28639163/agr-functionality-affects-clinical-outcomes-in-patients-with-persistent-methicillin-resistant-staphylococcus-aureus-bacteraemia
#1
C K Kang, Y K Kim, S-I Jung, W B Park, K-H Song, K-H Park, P G Choe, H-C Jang, S Lee, Y-S Kim, Y G Kwak, K T Kwon, S Kiem, C-J Kim, E S Kim, H B Kim
Methicillin-resistant Staphylococcus aureus bacteremia (MRSAB) often persists despite appropriate antibiotic therapy. It is unclear what microbiological factors contribute to poor clinical outcomes in persistent MRSAB (pMRSAB). We aimed to identify clinical and microbiological risk factors for in-hospital mortality in pMRSAB. We analysed MRSAB cases prospectively collected between 2009 and 2016 at 11 hospitals in Korea, defining cases of pMRSAB as MRSAB lasting ≥5 days despite administration of effective antibiotics...
June 21, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28638305/predictors-of-adverse-outcomes-in-children-with-staphylococcus-aureus-bacteremia
#2
Ganesh Kumarachandran, Jennifer Kristie Johnson, Debbie-Ann Shirley, Eileen Graffunder, Emily L Heil
OBJECTIVES: Staphylococcus aureus bacteremia is a common infection, associated with significant morbidity and mortality in children. Factors associated with adverse treatment outcomes are poorly understood in the pediatric population. METHODS: Our study compared clinical and microbiologic characteristics of children admitted during a 5-year period (2007-2012) to a large university-based hospital and found to have S aureus bacteremia with outcome measures, in order to identify risk factors associated with treatment failure (defined as 30-day mortality, delayed microbiologic resolution, or recurrence of S aureus bacteremia within 60 days of completing effective antibiotic therapy)...
May 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/28638293/septic-embolic-stroke-resulting-from-staphylococcus-lugdunensis-endocarditis
#3
Htoo Kyaw, Atif Z Shaikh, Gokul Yaratha, Misra Deepika
BACKGROUND: Staphylococcus lugdunensis, a member of the coagulase-negative staphylococci (CoNS), has been recognized as a causal organism for infective endocarditis since the 1980s. Although most CoNS have an insidious and chronic nature, they are involved in a variety of systemic infections. S lugdunensis infective endocarditis is a rare entity but is as catastrophic as Staphylococcus aureus infective endocarditis and requires aggressive antibiotic therapy and, typically, valve replacement...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/28634536/telavancin-a-novel-semisynthetic-lipoglycopeptide-agent-to-counter-the-challenge-of-resistant-gram-positive-pathogens
#4
REVIEW
Biswadeep Das, Chayna Sarkar, Debasmita Das, Amit Gupta, Arnav Kalra, Shubham Sahni
Telavancin (TD-6424), a semisynthetic lipoglycopeptide vancomycin-derivative, is a novel antimicrobial agent developed by Theravance for overcoming resistant Gram-positive bacterial infections, specifically methicillin-resistant Staphylococcus aureus (MRSA). The US Food and Drug Administration (USFDA) had approved telavancin in 2009 for the treatment of complicated skin and skin structure infections (cSSSIs) caused by Gram-positive bacteria, including MRSA (S. aureus, Streptococcus agalactiae, Streptococcus pyogenes, Streptococcus anginosus group, or Enterococcus faecalis)...
March 2017: Therapeutic Advances in Infectious Disease
https://www.readbyqxmd.com/read/28632826/-pyogenic-liver-abscess-in-children-clinical-experience-in-a-pediatric-reference-center
#5
Carolina Carballo, Claudia Cazes, Mariana Matsuda, M Laura Praino, Noemí Rivas, Eduardo López
INTRODUCTION: Liver abscess is a serious and an uncommon pediatric disease. OBJECTIVE AND METHOD: Description of 20 pediatric patients with liver abscess admitted in "Ricardo Gutierrez" Children's Hospital, a Tertiary Reference Center of Buenos Aires, between 2009 and 2015. RESULTS: The hospitalization rate was 35/100.000 admissions. Median age was 5 years old, male/female ratio 4/1. Five patients (25%) had predisposing factors. Median days at diagnosis were 12...
April 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28626538/septic-thrombophlebitis-with-persistent-methicillin-resistant-staphylococcus-aureus-bacteremia-and-de-novo-resistance-to-vancomycin-and-daptomycin
#6
Yael Koton, Zafrir Or, Naiel Bisharat
Persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia is associated with significant risk of mortality, especially when it occurs while on appropriate antimicrobial therapy. We herein describe an unusual case of a patient with prosthetic aortic tissue valve, who suffered from central venous catheter related MRSA bacteremia with septic thrombus formation in the superior vena cava. MRSA bacteremia persisted despite removal of the catheter and appropriate antimicrobial therapy including vancomycin, rifampin, and daptomycin...
May 31, 2017: Infectious Disease Reports
https://www.readbyqxmd.com/read/28623882/peripheral-venous-catheter-related-bloodstream-infection-is-associated-with-severe-complications-and-potential-death-a-retrospective-observational-study
#7
Akihiro Sato, Itaru Nakamura, Hiroaki Fujita, Ayaka Tsukimori, Takehito Kobayashi, Shinji Fukushima, Takeshi Fujii, Tetsuya Matsumoto
BACKGROUND: The purpose of this study was to identify the clinical characteristics and outcomes of peripheral vascular catheter-related bloodstream infections (PVC-BSIs) and determine the risk of severe complications or death. METHODS: We performed a retrospective observational study from June 2010 to April 2015 at two regional university-affiliated hospitals in Tokyo. We studied the clinical manifestations, underlying diseases, laboratory results, treatment methods, recurrence rates, and complications in 62 hospitalized patients diagnosed with PVC-BSIs by positive blood cultures...
June 17, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28622735/rifampin-resistant-staphylococcus-aureus-bacteremia-in-a-patient-on-chronic-rifaximin
#8
Paul O Lewis, Imran Khan, Paras Patel
No abstract text is available yet for this article.
July 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28611348/early-detection-of-subclinical-aortic-valve-endocarditis-with-the-cardiomems-heart-failure-system
#9
Sinan Sarsam, Georgy Kaspar, Shukri David, Marcel Zughaib
BACKGROUND The CardioMEMS Heart Failure System is a well validated tool to optimize management of systolic and diastolic heart failure and has been shown to reduce the risk of hospitalization by 37%. We are reporting a unique case of acute aortic valve insufficiency as a first sign of endocarditis, detected early in a patient with the CardioMEMS device. CASE REPORT A 79-year-old man with dual bioprosthetic mitral and aortic valve replacement and non-ischemic cardiomyopathy had a CardioMEMS Heart Failure System implanted 2 months following valve replacement surgery...
June 14, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28607050/mouse-model-of-hematogenous-implant-related-staphylococcus-aureus-biofilm-infection-reveals-therapeutic-targets
#10
Yu Wang, Lily I Cheng, David R Helfer, Alyssa G Ashbaugh, Robert J Miller, Alexander J Tzomides, John M Thompson, Roger V Ortines, Andrew S Tsai, Haiyun Liu, Carly A Dillen, Nathan K Archer, Taylor S Cohen, Christine Tkaczyk, C Kendall Stover, Bret R Sellman, Lloyd S Miller
Infection is a major complication of implantable medical devices, which provide a scaffold for biofilm formation, thereby reducing susceptibility to antibiotics and complicating treatment. Hematogenous implant-related infections following bacteremia are particularly problematic because they can occur at any time in a previously stable implant. Herein, we developed a model of hematogenous infection in which an orthopedic titanium implant was surgically placed in the legs of mice followed 3 wk later by an i.v...
June 12, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28596388/draft-genome-sequences-of-two-staphylococcus-aureus-strains-isolated-in-succession-from-a-case-of-bacteremia
#11
M D S Basco, J R Revollo, P B McKinzie, S Agnihothram, A Kothari, M Saccente, M E Hart
Staphylococcus aureus strains MEH1 and MEH7 were successively isolated from the blood of a patient with recurrent bacteremia. The submitted draft genomes of strains MEH1 and MEH7 are 2,914,972 and 2,911,704 bp, respectively.
June 8, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28592549/emergence-of-a-staphylococcus-aureus-clone-resistant-to-mupirocin-and-fusidic-acid-carrying-exotoxin-genes-and-causing-mainly-skin-infections
#12
Anastassios Doudoulakakis, Iris Spiliopoulou, Nikolaos Spyridis, Nikolaos Giormezis, John Kopsidas, Maria Militsopoulou, Evangelia Lebessi, Maria Tsolia
Objectives: Skin and soft tissue infections (SSTIs) caused by mupirocin-resistant Staphylococcus aureus strains have recently increased in our settings. We sought to evaluate the characteristics of these cases over a 43-month period.Methods: All community-acquired staphylococcal infections caused by mupirocin-resistant strains were retrospectively reviewed. Genes encoding high level (HLR) mupirocin resistance (mupA), fusidic acid resistance (fusB), ermA, ermC, PVL (lukS/lukF-PV), exfoliative toxins (eta, etb), fibronectin binding protein A (fnbA) were investigated in 102 preserved selected strains by PCRs...
June 7, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28589155/a-severe-case-of-cutaneous-adverse-drug-reaction-secondary-to-a-novice-drug-idelalisib
#13
Joseph Gabriel Gabriel, Aaysha Kapila, Alexei Gonzalez-Estrada
Phosphatidylinositol 3-kinase δ (PIK3δ) is a tyrosine kinase essential for B cell survival, making it an important target in the treatment of chronic lymphocytic leukemia. Idelalisib is an inhibitor of PIK3δ demonstrating initial success in disease response, but is now shown to have a decreased overall survival and life-threatening serious adverse events. The following is an unfortunate case of a grade III adverse skin reaction secondary to idelalisib with the likely complication of methicillin-resistant Staphylococcus aureus bacteremia...
April 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28584662/a-rare-case-of-acute-transverse-myelitis-associated-with-staphylococcusaureus-bacteremia-and-osteomyelitis
#14
Stamatis Karakonstantis, Despoina Galani, Sevasti Maragou, Asimina Koulouridi, Dimitra Kalemaki, Charalampos Lydakis
INTRODUCTION: Direct intramedullary infections are considered very rare. Only few reports of Staphylococcus aureus myelitis have been published. CASE PRESENTATION: Our patient, a 79-year-old male, presented with a 2-day history of high-grade fever and high inflammatory markers and progressively developed tetraplegia during hospitalization. Lumbar puncture revealed cerebrospinal fluid pleocytosis and a spinal cord MRI revealed transverse myelitis at the level of C3-C5 and possible osteomyelitis of C5-T1...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28579985/pathogenic-characteristics-of-staphylococcus-aureus-endovascular-infection-isolates-from-different-clonal-complexes
#15
Dafne Pérez-Montarelo, Esther Viedma, Mercedes Murcia, Irene Muñoz-Gallego, Nieves Larrosa, Patricia Brañas, Nuria Fernández-Hidalgo, Joan Gavaldà, Benito Almirante, Fernando Chaves
Staphylococcus aureus is a major cause of bacteremia and, even with appropriate clinical management, causes high morbidity, and mortality due to its involvement in endovascular complications and metastatic infections. Through different pathogenic in vivo and in vitro models we investigated the behavior of S. aureus most relevant clonal complexes (CCs) causing endovascular complications. We analyzed 14 S. aureus strains representing CC5, CC8, CC15, CC30, and CC45 that caused endovascular complications, including methicillin susceptible and resistant isolates and strains with different functionality of the agr global regulator...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28575112/molecular-epidemiology-of-staphylococcus-aureus-bacteremia-in-a-single-large-minnesota-medical-center-in-2015-as-assessed-using-mlst-core-genome-mlst-and-spa-typing
#16
Kyung-Hwa Park, Kerryl E Greenwood-Quaintance, James R Uhl, Scott A Cunningham, Nicholas Chia, Patricio R Jeraldo, Priya Sampathkumar, Heidi Nelson, Robin Patel
Staphylococcus aureus is a leading cause of bacteremia in hospitalized patients. Whether or not S. aureus bacteremia (SAB) is associated with clonality, implicating potential nosocomial transmission, has not, however, been investigated. Herein, we examined the epidemiology of SAB using whole genome sequencing (WGS). 152 SAB isolates collected over the course of 2015 at a single large Minnesota medical center were studied. Staphylococcus protein A (spa) typing was performed by PCR/Sanger sequencing; multilocus sequence typing (MLST) and core genome MLST (cgMLST) were determined by WGS...
2017: PloS One
https://www.readbyqxmd.com/read/28572795/cephalosporin-glycopeptide-combinations-for-use-against-clinical-methicillin-resistant-staphylococcus-aureus-isolates-enhanced-in-vitro-antibacterial-activity
#17
Hung-Jen Tang, Chih-Cheng Lai, Chi-Chung Chen, Chun-Cheng Zhang, Tzu-Chieh Weng, Wen-Liang Yu, Hung-Jui Chen, Yu-Hsin Chiu, Wen-Chien Ko, Yin-Ching Chuang
The empirical combination of both a beta-lactam and glycopeptide to counter potential staphylococcal pathogens may improve the clinical outcomes for cases of Staphylococcus aureus bacteremia. We reported comparative in vitro studies of combination effects of different cephalosporins (i.e., cefazolin, cefmetazole, cefotaxime, and cefepime) combined with glycopeptides for 34 randomly selected methicillin-resistant S. aureus (MRSA) isolates by three methods, including the checkerboard, time-killing, and combination MIC measurement methods...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28562284/epidemiology-of-methicillin-resistant-staphylococcus-aureus-bacteremia-in-children
#18
Rana F Hamdy, Alice J Hsu, Chris Stockmann, Jared A Olson, Matthew Bryan, Adam L Hersh, Pranita D Tamma, Jeffrey S Gerber
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia is associated with high rates of treatment failure in adults. The epidemiology, clinical outcomes, and risk factors for treatment failure associated with MRSA bacteremia in children are poorly understood. METHODS: Multicenter, retrospective cohort study of children ≤18 years hospitalized with MRSA bacteremia across 3 tertiary care children's hospitals from 2007 to 2014. Treatment failure was defined as persistent bacteremia >3 days, recurrence of bacteremia within 30 days, or attributable 30-day mortality...
May 5, 2017: Pediatrics
https://www.readbyqxmd.com/read/28553185/acute-hematogenous-osteomyelitis-presenting-as-a-cold-rib-in-a-child
#19
Michael J Annen, Mickaila J Johnston, Joe P Gormley, Eugene Silverman
A "cold" defect or an area of decreased radiotracer deposition is the less common appearance of acute hematogenous osteomyelitis (AHO) on a Tc99 m-methylene disphosphonate (Tc99 m-MDP) bone scan. Group A beta-hemolytic Streptococcus (GABHS) is a significantly less common cause of AHO than Staphylococcus aureus, particularly when the infection involves the pelvis or flat bones such as the ribs. Here, we present a case report of isolated acute "cold" hematogenous osteomyelitis in a rib of a child with GABHS bacteremia that was detected on 99Tc-MDP bone scan, with magnetic resonance imaging correlation, and pathologic confirmation after rib resection...
April 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28552097/community-acquired-staphylococcus-aureus-bacteremia-studies-of-risk-and-prognosis-with-special-attention-to-diabetes-mellitus-and-chronic-heart-failure
#20
Jesper Smit
Community-acquired Staphylococcus aureus bacteremia (CA-SAB) is a serious infection with detrimental clinical effects. Chronic diseases constitute some of the most important risk and prognostic factors for CA-SAB. The prevalence of diabetes and chronic heart failure (CHF) is rapidly increasing on a global scale, nevertheless, there are few data available specifically elucidating the influence of these chronic conditions on CA-SAB risk and outcome. Therefore, to extend the current knowledge, we aimed to I) elucidate the impact of different definitions of healthcare-associated (HCA) infection on the prevalence of HCA-SAB, patient characteristics, and mortality, II) to investigate whether diabetes is a risk factor for CA-SAB, III) to ascertain the prognostic influence of diabetes on CA-SAB outcome, and IV) to investigate the influence of CHF on mortality in patients with CA-SAB...
May 2017: Danish Medical Journal
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