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Staphylococcus aureus bacteremia

Fleur P Paling, Karina Olsen, Kristin Ohneberg, Martin Wolkewitz, Vance G Fowler, Mark J DiNubile, Hasan S Jafri, Frangiscos Sifakis, Marc J M Bonten, Stephan J Harbarth, Jan A J W Kluytmans
BACKGROUND: Identifying patients undergoing cardiothoracic surgery at high risk of Staphylococcus aureus surgical site infection (SSI) is a prerequisite for implementing effective preventive interventions. The objective of this study was to develop a risk prediction model for S. aureus SSI or bacteremia after cardiothoracic surgery based on pre-operative variables. MATERIALS/METHODS: Data from the Merck Phase IIb/III S. aureus vaccine (V710-P003) clinical trial were analyzed...
2018: PloS One
Esmeralda Highton, M Guadalupe Pérez, Carola Cedillo Villamagua, María I Sormani, María S Mussini, Adela Isasmendi, José Pinheiró, Vanesa Reijtman, Moira Taicz, Alejandra Mastroianni, María E García, María T Rosanova
INTRODUCTION: Osteoarticular infections are an important cause of morbidity and may present with bacteremia. The epidemiology has changed in recent years. OBJECTIVES: To describe the epidemiological, clinical, and evolutionary characteristics of children with osteoarticular infections and compare patients with and without bacteremia. POPULATION AND METHODS: Retrospective cohort. Patients younger than 18 years admitted between January 1st, 2016 and December 31st, 2016 suspected of osteoarticular infections who had undergone an arthrocentesis and/or joint biopsy were included...
April 1, 2018: Archivos Argentinos de Pediatría
Shuguang Li, Shijun Sun, Chentao Yang, Hongbin Chen, Yuyao Yin, Henan Li, Chunjiang Zhao, Hui Wang
To investigate the epidemiology and genetic structure of Staphylococcus aureus bacteremia in China, a total of 416 isolates from 22 teaching hospitals in 12 cities from 2013 and 2016 were characterized by antibiogram analysis, multilocus sequence typing (MLST), spa typing and staphylococcal cassette chromosome mec (SCC mec ) typing. The predominant meticillin-susceptible (MSSA) genotypes in 2013 were ST188 (19.1%), ST7 (8.7%), and ST398 (7.8%), respectively, and they continued to be the main genotypes in 2016...
2018: Frontiers in Microbiology
James B Wood, Gregory P Fricker, C Buddy Creech
We conducted a survey of pediatric infectious diseases providers in the Emerging Infections Network regarding the workup and treatment of children with Staphylococcus aureus bacteremia (SAB). We found significant practice variation in the management of children with SAB. These findings emphasize the need for further research to guide best practices.
March 8, 2018: Journal of the Pediatric Infectious Diseases Society
Eric Y Kok, Jesus G Vallejo, Lauren M Sommer, Louie Rosas, Sheldon L Kaplan, Kristina G Hulten, J Chase McNeil
Background : Methicillin-resistant Staphylococcus aureus (MRSA), particularly those belonging to the USA300 pulsotype, have been well described to cause severe osteoarticular infections (OAI). Vancomycin MIC ≥ 1.5 μg/ml has been demonstrated to contribute to disease severity in adults with MRSA and even MSSA bacteremia. Little data exists describing the outcomes of MSSA OAI in terms of molecular characteristics and vancomycin MIC. Methods : All patients/isolates were chosen from a surveillance study at Texas Children's Hospital (TCH)...
March 12, 2018: Antimicrobial Agents and Chemotherapy
Marguerite L Monogue, Jessica K Ortwine, Wenjing Wei, Khalid Eljaaly, Kavita P Bhavan
BACKGROUND: Anti-staphylococcal penicillins have long been the first-line treatment option for methicillin-susceptible Staphylococcus aureus (MSSA) infections. Recent retrospective data comparing nafcillin and cefazolin report similar clinical efficacy despite concerns about high inoculum MSSA infections. METHODS: This was a retrospective, non-inferiority, cohort study comparing treatment failure rates between nafcillin and cefazolin in patients with MSSA bacteremia from any source, other than meningitis...
March 8, 2018: Journal of Infection and Public Health
Nicolas Allou, Hugo Lo Pinto, Romain Persichini, Bruno Bouchet, Eric Braunberger, Nathalie Lugagne, Olivier Belmonte, Olivier Martinet, Benjamin Delmas, Laurence Dangers, Jérôme Allyn
Little is known about cannula-related infection (CRI) in patients supported by extracorporeal membrane oxygenation (ECMO). The aim of this study was to assess the incidence, the risk factors, prognosis, and microbiological characteristics of CRI in patients supported by ECMO. This retrospective cohort study was conducted in one intensive care unit (ICU). Among 220 consecutive patients with peripheral ECMO, 39 (17.7%) developed CRI. The incidence of CRI was 17.2 per 1,000 ECMO days. The main isolated microorganisms were Enterobacteriaceae (38%), Staphylococcus spp...
March 5, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
N Jung, S Rieg
AIMS: Staphylococcus aureus bloodstream infection is one of the most common serious bacterial infections worldwide. It represents a heterogenous clinical entity with a high risk of metastatic complications and a high in-hospital mortality ranging between 20 and 30%. The outcome can be improved by optimised diagnostic and therapeutic management. Thus, our minireview should provide important and often missed pieces of information in the management of S. aureus bloodstream infection. METHODS: We describe the essentials in the management of S...
March 6, 2018: Infection
Nicolas Cortes-Penfield, Nora T Oliver, Andrew Hunter, Maria Rodriguez-Barradas
No abstract text is available yet for this article.
March 6, 2018: Infectious Diseases
Chien-Fang Fu, Jiun-Da Huang, Jann-Tay Wang, Shu-Wen Lin, Chien-Chih Wu
BACKGROUND: Vancomycin is a standard treatment for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia, and its efficacy is closely linked to the recommended serum trough concentration of 15-20 mg/L. However, it is unknown how the pre-dialysis trough serum concentration (Cpre-HD) correlates with MRSA eradication in renal failure patients undergoing intermittent hemodialysis (HD). OBJECTIVE: To evaluate the relationship between Cpre-HD and the treatment outcomes in this population...
2018: PloS One
J S Davis, J Turnidge, S Y C Tong
BACKGROUND AND OBJECTIVES: Antistaphylococcal penicillins (ASPs) are recommended as first line treatment for invasive infections caused by methicillin-susceptible Staphylococcus aureus (MSSA). Cefazolin is an alternative option, but there is theoretical concern about using it due to the fact that some MSSA strains produce beta-lactamases active against cefazolin. We aimed to compare outcomes from patients with MSSA infections treated with flucloxacillin and cefazolin. METHODS: We analysed data from The Australia and New Zealand Co-operative Outcomes of Staphylococcal Sepsis (ANZCOSS) observational study, which included all consecutive unique episodes of Staphylococcus aureus bacteraemia from 27 hospital-based or independent microbiology laboratories from January 2007 to September 2013...
February 27, 2018: International Journal of Antimicrobial Agents
Stamatis Karakonstantis, Dimitra Kalemaki
BACKGROUND: Staphylococcus aureus bacteriuria (SABU) concomitant to S. aureus bacteremia (SAB) has been associated with deep-seated infections and worse prognosis. However, the relevant studies were small and inconsistent. Here, we aim to provide a review of the relevant literature, and a meta-analysis of these studies. METHODS: We searched PubMed and Scopus for studies comparing patients with SAB and concomitant SABU to patients with SAB without SABU. RESULTS: Nine relevant studies were identified, involving 1429 patients with SAB, of whom 18...
February 28, 2018: Infectious Diseases
Elena Espejo, Marta Andrés, Rosa-Maria Borrallo, Emma Padilla, Enric Garcia-Restoy, Feliu Bella
The objective of this study is to evaluate the clinical and microbiological characteristics of bacteremia associated with pressure ulcers (BAPU) and factors associated with mortality. This study was a prospective observational cohort study of patients with BAPU at a teaching hospital between January 1984 and December 2015. Fifty-six episodes were included. The incidence of BAPU decreased from 2.78 cases per 10,000 hospital discharges in the period from 1984 to 1999 to 1.05 cases per 10,000 hospital discharges in the period from 2000 to 2015 (p < 0...
February 26, 2018: European Journal of Clinical Microbiology & Infectious Diseases
Cesar A Arias, Jinnethe Reyes, Lina Paola Carvajal, Sandra Rincon, Lorena Diaz, Diana Panesso, Gabriel Ibarra, Rafael Rios, Jose M Munita, Mauro J Salles, Carlos Alvarez-Moreno, Jaime Labarca, Coralith Garcia, Carlos M Luna, Carlos Mejia-Villatoro, Jeannete Zurita, Manuel Guzman-Blanco, Eduardo Rodriguez-Noriega, Apurva Narechania, Laura J Rojas, Paul J Planet, George M Weinstock, Eduardo Gotuzzo, Carlos Seas
No abstract text is available yet for this article.
March 2018: Antimicrobial Agents and Chemotherapy
Trang D Trinh, Evan J Zasowski, Kimberly C Claeys, Anthony M Casapao, Matthew Compton, Abdalhamid Lagnf, Shravya D Kidambi, Donald P Levine, Michael J Rybak
INTRODUCTION: Vancomycin remains the standard of care for invasive methicillin-resistant Staphylococcus aureus (MRSA) infections. Treatment failures from heteroresistant vancomycin-intermediate subpopulations (hVISA) are challenging to detect. Minimum inhibitory concentrations (MIC) identified by modified population analysis profile (PAP) is an alternative testing method. The aim of this study was to evaluate the role of PAP MIC on vancomycin failures in two high inoculum infections: MRSA infective endocarditis and pneumonia...
February 22, 2018: Infectious Diseases and Therapy
Sara Cajander, Gunlög Rasmussen, Elisabet Tina, Anders Magnuson, Bo Söderquist, Jan Källman, Kristoffer Strålin
OBJECTIVE: In the pathogenesis of sepsis, activation of both pro- and anti-inflammatory responses are key components, but knowledge is lacking on the association between bacterial etiology and development of dysregulated responses with sustained immunosuppression. The aim of this study was to evaluate how the immunosupression marker HLA-DR on monocytes (mHLA-DR) is associated with bacterial etiology and markers of inflammation during the clinical trajectory of bloodstream infection (BSI)...
2018: PloS One
Benjamin H Gern, Alexander L Greninger, Scott J Weissman, Jennifer R Stapp, Yue Tao, Xuan Qin
OBJECTIVES: In vitro trends of cefazolin and ceftriaxone susceptibilities from pediatric clinical isolates of methicillin-susceptible Staphylococcus aureus (MSSA) between 2011 and 2016 were analyzed for surveillance. METHODS: Our laboratory continues to use agar disk diffusion for staphylococcal susceptibilities applying Clinical Laboratory Standard Institute's 2012 breakpoints. RESULTS: A total of 3992 MSSA clinical isolates in the last 6 years were analyzed for their in vitro cefazolin and ceftriaxone susceptibilities...
February 20, 2018: Annals of Clinical Microbiology and Antimicrobials
Joshua T Freeman, Matthew R Blakiston, Deverick J Anderson
The correlations between census-derived sociodemographic variables and hospital-onset methicillin-resistant Staphylococcus aureus bacteremia (HO-MRSAB) rates were examined at the US state level. On multivariable analysis, only percent African American remained statistically significant. This finding highlights an important disparity and suggests that risk adjustment is needed when comparing HO-MRSAB rates among US states. Infect Control Hosp Epidemiol 2018;1-3.
February 19, 2018: Infection Control and Hospital Epidemiology
Akinori Maeda, Isaku Saku, Shotaro Kanda, Kazuo Saita, Toru Akiyama
INTRODUCTION: Obturator internus muscle (OIM) abscess is a rare condition, usually affecting children after trauma or muscular effort. Blood cultures always yield positive findings, with Staphylococcus aureus being the most common culprit. There are few reports in adults. PRESENTATION OF CASE: We report a case of OIM abscess in an adult. A 24-year-old male was admitted to our hospital because of right hip pain and fever. He was diagnosed with OIM abscess, and methicillin-resistant Staphylococcus aureus (MRSA) was detected on bacterial examination...
February 9, 2018: International Journal of Surgery Case Reports
Nick Daneman, Asgar H Rishu, Ruxandra Pinto, Pierre Aslanian, Sean M Bagshaw, Alex Carignan, Emmanuel Charbonney, Bryan Coburn, Deborah J Cook, Michael E Detsky, Peter Dodek, Richard Hall, Anand Kumar, Francois Lamontagne, Francois Lauzier, John C Marshall, Claudio M Martin, Lauralyn McIntyre, John Muscedere, Steven Reynolds, Wendy Sligl, Henry T Stelfox, M Elizabeth Wilcox, Robert A Fowler
BACKGROUND: Shorter-duration antibiotic treatment is sufficient for a range of bacterial infections, but has not been adequately studied for bloodstream infections. Our systematic review, survey, and observational study indicated equipoise for a trial of 7 versus 14 days of antibiotic treatment for bloodstream infections; a pilot randomized clinical trial (RCT) was a necessary next step to assess feasibility of a larger trial. METHODS: We conducted an open, pilot RCT of antibiotic treatment duration among critically ill patients with bloodstream infection across 11 intensive care units (ICUs)...
February 17, 2018: Trials
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