keyword
MENU ▼
Read by QxMD icon Read
search

Staphylococcus aureus bacteremia

keyword
https://www.readbyqxmd.com/read/29333818/community-acquired-methicillin-resistant-staphylococcus-aureus-infections-hospitalization-and-case-fatality-risk-in-10-pediatric-facilities-in-argentina
#1
Ángela Gentile, Julia Bakir, Gabriela Ensinck, Aldo Cancellara, Enrique V Casanueva, Verónica Firpo, Martín Caruso, María F Lución, Alejandro Santillán Iturres, Fabiana Molina, Héctor J Abate, Andrea Gajo Gane, Santiago López Papucci
INTRODUCTION: Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections are prevalent both in Argentina and worldwide, and they may have a severe clinical course. OBJECTIVES: To estimate the hospitalization rate and case fatality risk factors of CA-MRSA infection. METHODS: Cross-sectional, analytical study. All patients < 15 years old with community-acquired Staphylococcus aureus (CA-SA) infections admitted to 10 pediatric facilities between January 2012 and December 2014 were included...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29320659/iris-abscess
#2
Xuejing Chen, Caroline R Baumal
A 25-year-old woman presented to the retina clinic with progressive pain and redness in her right eye. She had a history of intravenous drug use, and 1 week before presentation she had received a diagnosis of methicillin-sensitive Staphylococcus aureus bacteremia and endocarditis, for which she was..
January 11, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29305961/no-effect-of-vancomycin-mic-%C3%A2-1-5-mg-l-on-treatment-outcome-in-methicillin-susceptible-staphylococcus-aureus-bacteremia
#3
Kevin Bouiller, Caroline Laborde, Serge Ludwig Aho, Didier Hocquet, André Pechinot, Vincent Le Moing, Xavier Bertrand, Lionel Piroth, Catherine Chirouze
OBJECTIVES: The vancomycin minimum inhibitory concentration (MIC) has been shown to affect the outcome of methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia. In this study, the outcomes of patients with MSSA bacteremia, with a vancomycin MIC≥ 1.5 mg/L were assessed. METHODS: A prospective cohort of patients with MSSA bacteremia in two tertiary-care hospitals was collected. Vancomycin MIC was determined by Etest. SA strains were categorized as low (<1...
January 3, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29300363/unusually-high-incidences-of-staphylococcus-aureus-infection-within-studies-of-ventilator-associated-pneumonia-prevention-using-topical-antibiotics-benchmarking-the-evidence-base
#4
James C Hurley
Selective digestive decontamination (SDD, topical antibiotic regimens applied to the respiratory tract) appears effective for preventing ventilator associated pneumonia (VAP) in intensive care unit (ICU) patients. However, potential contextual effects of SDD on Staphylococcus aureus infections in the ICU remain unclear. The S. aureus ventilator associated pneumonia (S. aureus VAP), VAP overall and S. aureus bacteremia incidences within component (control and intervention) groups within 27 SDD studies were benchmarked against 115 observational groups...
January 4, 2018: Microorganisms
https://www.readbyqxmd.com/read/29298323/implementation-of-global-antimicrobial-resistance-surveillance-system-glass-in-patients-with-bacteremia
#5
Rujipas Sirijatuphat, Kantarida Sripanidkulchai, Adhiratha Boonyasiri, Pinyo Rattanaumpawan, Orawan Supapueng, Pattarachai Kiratisin, Visanu Thamlikitkul
The global antimicrobial resistance surveillance system (GLASS) was launched by the World Health Organization (WHO) in 2015. GLASS is a surveillance system for clinical specimens that are sent to microbiology laboratory for clinical purposes. The unique feature of GLASS is that clinical data is combined with microbiological data, and deduplication of the microbiological results is performed. The objective of the study was to determine feasibility and benefit of GLASS for surveillance of blood culture specimens...
2018: PloS One
https://www.readbyqxmd.com/read/29297750/a-d-alanine-auxotrophic-live-vaccine-is-effective-against-lethal-infection-caused-by-staphylococcus-aureus
#6
Miriam Moscoso, Patricia García, Maria P Cabral, Carlos Rumbo, Germán Bou
Staphylococcus aureus infections are becoming a major global health issue due to the rapid emergence of multidrug-resistant strains. Therefore, there is an urgent need to develop an effective vaccine to prevent and control these infections. In order to develop a universal immunization strategy, we constructed a mutant derivative of S. aureus 132 which lacks the genes involved in D-alanine biosynthesis, a structural component of cell wall peptidoglycan. This unmarked deletion mutant requires the exogenous addition of D-alanine for in vitro growth...
January 3, 2018: Virulence
https://www.readbyqxmd.com/read/29235661/association-of-higher-daptomycin-dose-%C3%A2-7-mg-kg-with-improved-survival-in-patients-with-methicillin-resistant-staphylococcus-aureus-bacteremia
#7
Tristan T Timbrook, Aisling R Caffrey, Megan K Luther, Vrishali Lopes, Kerry L LaPlante
STUDY OBJECTIVE: Current guidelines recommend higher daptomycin doses than the daptomycin label dose of 6 mg/kg for methicillin-resistant Staphylococcus aureus (MRSA) bacteremia; however, the evidence supporting this recommendation is from in vitro and cases series studies. The objective of this study was to evaluate the comparative effectiveness of the daptomycin label dose versus higher daptomycin doses in patients with MRSA bacteremia. DESIGN: Retrospective national cohort study...
December 13, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/29228127/antibiotic-resistance-and-the-risk-of-recurrent-bacteremia
#8
Sjoukje H S Woudt, Sabine C de Greeff, Annelot F Schoffelen, Anne L M Vlek, Marc J M Bonten
Background: Direct health effects of antibiotic resistance are difficult to assess. We quantified the risk of recurrent bacteremia associated with antibiotic resistance. Methods: We extracted antimicrobial susceptibility testing data on blood isolates of Enterobacteriaceae, Pseudomonas spp., Enterococcus spp. and Staphylococcus aureus from the Dutch surveillance system for antimicrobial resistance between 2008 and 2017. First and first recurrent (4-30days) bacteremia episodes were categorized as susceptible, single non-susceptible or co-non-susceptible (I/R), to 3rd generation cephalosporins -/+ carbapenems (Enterobacteriaceae), ceftazidime -/+ carbapenems (Pseudomonas spp...
December 7, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29222405/multiple-weekly-dalbavancin-dosing-for-the-treatment-of-native-vertebral-osteomyelitis-caused-by-methicillin-resistant-staphylococcus-aureus-a-case-report
#9
Thamer A Almangour, Valerie Fletcher, Mohammed Alessa, Abdullah A Alhifany, Deanne Tabb
BACKGROUND Native vertebral osteomyelitis (NVO) is a common form of hematogenous osteomyelitis, with Staphylococcus aureus (S. aureus) being the most commonly isolated organism. Dalbavancin is approved by the US Food and Drug Administration (FDA) for the treatment of acute bacterial skin and skin structure infections (ABSSSI) and has a sufficiently promising pharmacokinetic and pharmacodynamic profile to be considered for the treatment of vertebral osteomyelitis. We describe here what is probably the first reported case of using multiple weekly dalbavancin to treat a complicated methicillin-resistant Staphylococcus aureus (MRSA) bacteremia and vertebral osteomyelitis...
December 9, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29203479/host-pathogen-treatment-triad-host-factors-matter-most-in-mrsa-bacteremia-outcomes
#10
M Cristina Vazquez Guillamet, Rodrigo Vazquez, Benjamin Deaton, Jenny Shroba, Laia Vazquez, Renee-Claude Mercier
Background: Previous studies have separately emphasized the importance of host, pathogen and treatment characteristics in determining short term or in-hospital mortality for patients with methicillin resistant Staphylococcus aureus (MRSA) bloodstream infections. Less is known about the relative importance of these factors and their interaction in determining short, medium and long-term mortality.Methods: This is an observational cohort study where all patients admitted to University of New Mexico Health Sciences Center (UNM HSC) between July 2002 and August 2013 with MRSA positive blood cultures were recorded...
December 4, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29189727/staphylococcus-aureus-bacteremia-from-diffuse-muscular-infection-following-acupuncture-visualized-by-18f-fdg-pet-ct-and-mri
#11
Andreas Knudsen, Carsten Thomsen, Lothar Wiese
We describe the clinical course of a 60-year old male admitted with Staphylococcus aureus bacteremia and back-pain. The patient was suspected of having spondylitis and treated as such with antibiotics; however, both fluorine-18 fluoro-2-deoxy-d-glucose (18F-FDG) positron-emission tomography and magnetic resonance imaging (MRI) with iv contrast showed significant inflammation of muscles and subcutaneous soft tissue in relation to the patients back and left shoulder, but no signs of the working diagnosis of spondylitis...
November 30, 2017: Diagnostics
https://www.readbyqxmd.com/read/29180523/efficacy-of-novel-anti-staphylococcal-ectolysin-p128-in-a-rat-model-of-methicillin-resistant-staphylococcus-aureus-mrsa-bacteremia
#12
Shankaramurthy Channabasappa, Murali Durgaiah, Ravisha Chikkamadaiah, Senthil Kumar, Amruta Joshi, Bharathi Sriram
Staphylococcus aureus (S.aureus) causes systemic infections with high morbidity and mortality and emergence of drug resistance strains are a rapidly growing clinical concerns. Novel therapeutic agents are required to tackle S.aureus infections. P128 is a bacteriophage-derived chimeric ectolysin with potent and rapid bactericidal activity on S. aureus In the current study, efficacy of P128 was evaluated in a newly-developed rat model of S. aureus bacteremia. Prior to in vivo testing, P128 was shown to be stable in whole blood by incubation in rat blood for up to 6 hrs and testing of its bactericidal activity against MRSA isolate USA 300...
November 27, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29169153/optimal-trough-concentration-of-teicoplanin-in-febrile-neutropenic-patients-with-hematological-malignancy
#13
Yuhki Sato, Kazufumi Hiramatsu, Yosuke Suzuki, Ryota Tanaka, Tetsuya Kaneko, Ko Nonoshita, Masao Ogata, Jun-Ichi Kadota, Hiroki Itoh
BACKGROUND: Teicoplanin is a glycopeptide antibiotic currently used for the treatment of methicillin-resistant Staphylococcus aureus. The need for therapeutic drug monitoring of teicoplanin has been increasingly highlighted as important. It is generally accepted that whereas a plasma trough concentration (Cmin) of ≥10 mg/L is appropriate for the majority of infections, it should exceed 20 mg/L for severe infections. The target Cmin of teicoplanin in patients with febrile neutropenia (FN) has not been reported...
November 24, 2017: Chemotherapy
https://www.readbyqxmd.com/read/29163457/the-agr-quorum-sensing-system-represses-persister-formation-through-regulation-of-phenol-soluble-modulins-in-staphylococcus-aureus
#14
Tao Xu, Xu-Yang Wang, Peng Cui, Yu-Meng Zhang, Wen-Hong Zhang, Ying Zhang
The opportunistic pathogen Staphylococcus aureus has become an increasing threat to public health. While the Agr quorum sensing (QS) system is a master regulator of S. aureus virulence, its dysfunction has been frequently reported to promote bacteremia and mortality in clinical infections. Here we show that the Agr system is involved in persister formation in S. aureus. Mutation of either agrCA or agrD but not RNAIII resulted in increased persister formation of stationary phase cultures. RNA-seq analysis showed that in stationary phase AgrCA/AgrD and RNAIII mutants showed consistent up-regulation of virulence associated genes (lip and splE, etc...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29161942/trends-in-incidence-and-resistance-patterns-of-staphylococcus-aureus-bacteremia
#15
Elina Jokinen, Janne Laine, Reetta Huttunen, Outi Lyytikäinen, Risto Vuento, Jaana Vuopio, Jaana Syrjänen
BACKGROUND: Staphylococcus aureus bacteremia (SAB) causes a significant burden on the population. Several infection control measures have been implemented in Pirkanmaa county to combat a local epidemic with methicillin-resistant Staphylococcus aureus (MRSA). We aimed to study the epidemiology of SAB and antibiotic resistance of S. aureus and the possible influence of improved infection control. METHODS: Register data from 2005 to 2015 were retrospectively analysed to study the antimicrobial susceptibility, the incidence and mortality in SAB in a population-based setting...
January 2018: Infectious Diseases
https://www.readbyqxmd.com/read/29156865/antibacterial-resistance-patterns-and-incidence-of-hospital-acquired-staphylococcus-aureus-bacteremia-in-a-tertiary-care-educational-hospital-in-turkey-a-perspective-from-2001-to-2013
#16
Oğuz Reşat Sipahi, Serhat Uysal, Sabire Şöhret Aydemir, Hüsnü Pullukçu, Meltem Taşbakan, Alper Tünger, Fatma Feriha Çilli, Tansu Yamazhan, Bilgin Arda, Hilal Sipahi, Sercan Ulusoy
Background/aim: Staphylococcus aureus is an important nosocomial pathogen and a successful antimicrobial-resistance developer. In this study we retrospectively evaluated the resistance patterns and incidence of microbiologically confirmed nosocomial bacteremia (MCNB) related S. aureus strains between 2001 and 2013. Materials and methods: Any patient in whom S. aureus was isolated in at least one set of blood cultures (sent to the bacteriology laboratory 72 h after hospital admission) was considered to have MCNB...
August 23, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29153470/impact-of-a-pharmacist-driven-care-package-on-staphylococcus-aureus-bacteremia-management-in-a-large-community-healthcare-network-a-propensity-score-matched-quasi-experimental-study
#17
Jordan R Smith, Jeremy J Frens, Cynthia B Snider, Kimberly C Claeys
OBJECTIVES: Staphylococcus aureus bacteremia (SAB) is an important cause of morbidity and mortality. Suboptimal treatment has been associated with poor patient outcomes. Our antimicrobial stewardship program (ASP) evaluated SAB management based on predefined performance measures both prior to and after instituting a "care package" intervention led by clinical pharmacists and infectious diseases physicians. The primary outcome included a 4-point "optimal care score" (OCS) consisting of targeted antibiotic therapy within 24hours, repeating blood cultures, antibiotic duration assessment, and appropriate duration of therapy...
October 7, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29149185/linezolid-and-atorvastatin-impact-on-pneumonia-caused-by-staphyloccocus-aureus-in-rabbits-with-or-without-mechanical-ventilation
#18
Laure-Anne Pauchard, Mathieu Blot, Rémi Bruyere, Saber-Davide Barbar, Delphine Croisier, Lionel Piroth, Pierre-Emmanuel Charles
Pneumonia may involve methicillin-resistant Staphylococcus aureus (MRSA), with elevated rates of antibiotics failure. The present study aimed to assess the effect of statins given prior to pneumonia development. Spontaneously breathing (SB) or mechanically ventilated (MV) rabbits with pneumonia received atorvastatin alone, linezolid (LNZ) alone, or a combination of both (n = 5 in each group). Spontaneously breathing and MV untreated infected animals (n = 11 in each group), as well as uninfected animals (n = 5 in each group) were used as controls...
2017: PloS One
https://www.readbyqxmd.com/read/29137718/telavancin-for-the-treatment-of-methicillin-resistant-staphylococcus-aureus-bone-and-joint-infections
#19
Julie Harting, Francisco Fernandez, Rob Kelley, Tim Wiemken, Paula Peyrani, Julio Ramirez
This retrospective, case series describes our experience with the use of telavancin in patients with methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis and prosthetic joint infection. The primary objectives were clinical outcomes and adverse events (AEs), and a secondary outcome described microbiological susceptibility. Fourteen patients were enrolled. Median duration of therapy was 58 days, and four patients had concurrent bacteremia. End-of-treatment outcomes were available in 78% of patients, with a clinical success rate of 91%...
December 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29134582/long-term-efficacy-of-comprehensive-multidisciplinary-antibiotic-stewardship-programs-centered-on-weekly-prospective-audit-and-feedback
#20
Takeshi Kimura, Atsushi Uda, Tomoyuki Sakaue, Kazuhiko Yamashita, Tatsuya Nishioka, Sho Nishimura, Kei Ebisawa, Manabu Nagata, Goh Ohji, Tatsuya Nakamura, Chihiro Koike, Mari Kusuki, Takeshi Ioroi, Akira Mukai, Yasuhisa Abe, Hiroyuki Yoshida, Midori Hirai, Soichi Arakawa, Ikuko Yano, Kentaro Iwata, Issei Tokimatsu
OBJECTIVE: To evaluate the long-term effects of comprehensive antibiotic stewardship programs (ASPs) on antibiotic use, antimicrobial-resistant bacteria, and clinical outcomes. DESIGN: Before-after study. SETTING: National university hospital with 934 beds. INTERVENTION: Implementation in March 2010 of a comprehensive ASPs including, among other strategies, weekly prospective audit and feedback with multidisciplinary collaboration...
November 13, 2017: Infection
keyword
keyword
1954
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"