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https://www.readbyqxmd.com/read/28324915/alcohol-related-blackouts-negative-alcohol-related-consequences-and-motivations-for-drinking-reported-by-newly-matriculating-transgender-college-students
#1
Larry A Tupler, Daniel Zapp, William DeJong, Maryam Ali, Sarah O'Rourke, John Looney, H Scott Swartzwelder
BACKGROUND: Many transgender college students struggle with identity formation and other emotional, social, and developmental challenges associated with emerging adulthood. A potential maladaptive coping strategy employed by such students is heavy drinking. Prior literature has suggested greater consumption and negative alcohol-related consequences (ARCs) in transgender students compared with their cisgender peers, but little is known about their differing experiences with alcohol-related blackouts (ARBs)...
March 21, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28324725/tailoring-a-compact-and-stable-langmuir-bi-dimensional-pbx-based-layered-perovskite-film-at-the-air-water-interface-and-on-solid-support
#2
Luisa Ariza-Carmona, Gonzalo García-Espejo, María T Martín-Romero, Luis Camacho
The present work studies the stability of Langmuir organic-inorganic superlattice materials thin films consisting of layered perovskite-based films with controlled 2D framework as well as to design experimental conditions for increasing the efficiency of the organic-inorganic perovskite motif by mechanical stimulus. Therefore, a whole covering of the air/water interface by a compact and stable lead-based layered perovskite structure is pursued. A 2D layered perovskite-type hybrid structure of the form [(CH3(CH2)19NH3)2(PbX4)], X=Cl, and Br, in which, two-dimensional sheets stabilized by a inner bilayer of organic monoammonium cation matrix, is mechanically tailored by successive compression-expansion cycles...
March 14, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28324176/bhlha9-regulates-apical-ectodermal-ridge-formation-during-limb-development
#3
Kensuke Kataoka, Takahide Matsushima, Yoshiaki Ito, Tempei Sato, Shigetoshi Yokoyama, Hiroshi Asahara
Split hand/foot malformation (SHFM) and SHFM combined with long-bone deficiency (SHFLD) are congenital dysgeneses of the limb. Although six different loci/mutations (SHFM1-SHFM6) have been found from studies on families with SHFM, the causes and associated pathogenic mechanisms for a large number of patients remain unidentified. On the basis of the identification of a duplicated gene region involving BHLHA9 in some affected families, BHLHA9 was identified as a novel SHFM/SHFLD-related gene. Although Bhlha9 is predicted to participate in limb development as a transcription factor, its precise function is unclear...
March 21, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28323936/the-steroid-metabolome-in-the-isolated-ovarian-follicle-and-its-response-to-androgen-exposure-and-antagonism
#4
Marie Lebbe, Angela E Taylor, Jenny A Visser, Jackson Kirkman-Brown, Teresa K Woodruff, Wiebke Arlt
The ovarian follicle is a major site of steroidogenesis, crucially required for normal ovarian function and female reproduction. Our understanding of androgen synthesis and metabolism in the developing follicle has been limited by sensitivity and specificity issues of previously used assays. Here we used liquid chromatography-tandem mass spectrometry to map the stage-dependent endogenous steroid metabolome in an encapsulated in vitro follicle growth system, from murine secondary through antral follicles. Furthermore, follicles were cultured in the presence of androgen precursors, non-aromatizable active androgen and androgen receptor (AR) antagonist to assess effects on steroidogenesis and follicle development...
February 23, 2017: Endocrinology
https://www.readbyqxmd.com/read/28323621/smoc-can-act-as-both-an-antagonist-and-an-expander-of-bmp-signaling
#5
J Terrig Thomas, D Eric Dollins, Kristin R Andrykovich, Tehyen Chu, Brian G Stultz, Deborah A Hursh, Malcolm Moos
The matricellular protein SMOC (Secreted Modular Calcium binding protein) is conserved phylogenetically from vertebrates to arthropods. We showed previously that SMOC inhibits bone morphogenetic protein (BMP) signaling downstream of its receptor via activation of mitogen-activated protein kinase (MAPK) signaling. In contrast, the most prominent effect of the Drosophila orthologue, pentagone (pent), is expanding the range of BMP signaling during wing patterning. Using SMOC deletion constructs we found that SMOC-∆EC, lacking the extracellular calcium binding (EC) domain, inhibited BMP2 signaling, whereas SMOC-EC (EC domain only) enhanced BMP2 signaling...
March 21, 2017: ELife
https://www.readbyqxmd.com/read/28323616/yap-is-essential-for-mechanical-force-production-and-epithelial-cell-proliferation-during-lung-branching-morphogenesis
#6
Chuwen Lin, Erica Yao, Kuan Zhang, Xuan Jiang, Stacey Croll, Katherine Thompson-Peer, Pao-Tien Chuang
Branching morphogenesis is a fundamental program for tissue patterning. We show that active YAP, a key mediator of Hippo signaling, is distributed throughout the murine lung epithelium and loss of epithelial YAP severely disrupts branching. Failure to branch is restricted to regions where YAP activity is removed. This suggests that YAP controls local epithelial cell properties. In support of this model, mechanical force production is compromised and cell proliferation is reduced in Yap mutant lungs. We propose that defective force generation and insufficient epithelial cell number underlie the branching defects...
March 21, 2017: ELife
https://www.readbyqxmd.com/read/28319891/time-and-cell-resolved-dynamics-of-redox-sensitive-nrf2-hif-and-nf-%C3%AE%C2%BAb-activities-in-3d-spheroids-enriched-for-cancer-stem-cells
#7
Anna P Kipp, Stefanie Deubel, Elias S J Arnér, Katarina Johansson
Cancer cells have an altered redox status, with changes in intracellular signaling pathways. The knowledge of how such processes are regulated in 3D spheroids, being well-established tumor models, is limited. To approach this question we stably transfected HCT116 cells with a pTRAF reporter that enabled time- and cell-resolved activity monitoring of three redox-regulated transcription factors Nrf2, HIF and NF-κB in spheroids enriched for cancer stem cells. At the first day of spheroid formation, these transcription factors were activated and thereafter became repressed...
March 10, 2017: Redox Biology
https://www.readbyqxmd.com/read/28319378/computational-study-of-13c-nmr-csa-patterns-in-c20h10-and-c20h10-4-insights-into-their-variation-upon-planarization-and-formation-of-concentric-aromatic-species-in-the-smaller-isolated-pentagon-structural-motif
#8
Alvaro Muñoz-Castro, Wilson Caimanque-Aguilar, Cesar Morales-Verdejo
Corannulene, C20H10, exhibits a concave surface in the ground state which is able to experience a bowl-to-bowl inversion through a planar conformation. Such structure is the smaller example resembling an isolated-pentagon motif, as a relevant fragment in Fullerene chemistry. Here, we explored the differences between bowl and planar conformations involving both energetic and 13C-NMR properties, for the neutral and tetraanionic species by using DFT methods. This allows to understand the variation of the chemical environment at the carbon atoms upon planarization of this representive motif...
March 20, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28319290/role-of-dissolved-and-molecular-oxygen-on-cu-and-ptcu-alloy-particle-structure-during-laser-ablation-synthesis-in-liquids
#9
Galina Marzun, Helmut Bönnemann, Christian Lehmann, Bernd Spliethoff, Claudia Weidenthaler, Stephan Barcikowski
The role of molecular oxygen dissolved in the solvent is often discussed as being an influential factor on particle oxidation during pulsed laser ablation in liquids. However, the formation of the particles during laser synthesis takes place under extreme conditions that enable the decomposition of the liquid medium. Reactive species of the solvent may then affect particle formation due to a chemical reaction in the reactive plasma. Experimental results show a difference between the role of dissolved molecular oxygen and the contribution from the oxygen in water molecules...
March 20, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28317948/local-remodeling-of-synthetic-extracellular-matrix-microenvironments-by-co-cultured-endometrial-epithelial-and-stromal-cells-enables-long-term-dynamic-physiological-function
#10
Christi D Cook, Abby S Hill, Margaret Guo, Linda Stockdale, Julia P Papps, Keith B Isaacson, Douglas A Lauffenburger, Linda G Griffith
Mucosal barrier tissues, comprising a layer of tightly-bonded epithelial cells in intimate molecular communication with an underlying matrix-rich stroma containing fibroblasts and immune cells, are prominent targets for drugs against infection, chronic inflammation, and other disease processes. Although human in vitro models of such barriers are needed for mechanistic studies and drug development, differences in extracellular matrix (ECM) needs of epithelial and stromal cells hinder efforts to create such models...
March 20, 2017: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/28317945/identification-and-comparative-profiling-of-mirnas-in-herbaceous-peony-paeonia-lactiflora-pall-with-red-yellow-bicoloured-flowers
#11
Daqiu Zhao, Mengran Wei, Min Shi, Zhaojun Hao, Jun Tao
Herbaceous peony (Paeonia lactiflora Pall.) is popular worldwide because of its gorgeous flower colour, and the yellow flower is the rarest. However, its mechanism of yellow formation is still unexplored from the post-translational level. In this study, the anatomy of the petal, cell sap pH and metal elements were investigated in bicoloured flower cultivar 'Jinhui' with red outer-petal and yellow inner-petal, and the yellow formation was influenced by the anatomy of petal, while not by the cell sap pH and metal elements...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28317930/achromatic-light-patterning-and-improved-image-reconstruction-for-parallelized-resolft-nanoscopy
#12
Andriy Chmyrov, Marcel Leutenegger, Tim Grotjohann, Andreas Schönle, Jan Keller-Findeisen, Lars Kastrup, Stefan Jakobs, Gerald Donnert, Steffen J Sahl, Stefan W Hell
Fluorescence microscopy is rapidly turning into nanoscopy. Among the various nanoscopy methods, the STED/RESOLFT super-resolution family has recently been expanded to image even large fields of view within a few seconds. This advance relies on using light patterns featuring substantial arrays of intensity minima for discerning features by switching their fluorophores between 'on' and 'off' states of fluorescence. Here we show that splitting the light with a grating and recombining it in the focal plane of the objective lens renders arrays of minima with wavelength-independent periodicity...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28317863/dynamic-monitoring-of-membrane-nanotubes-formation-induced-by-vaccinia-virus-on-a-high-throughput-microfluidic-chip
#13
Min Xiao, Na Xu, Cheng Wang, Dai-Wen Pang, Zhi-Ling Zhang
Membrane nanotubes (MNTs) are physical connections for intercellular communication and induced by various viruses. However, the formation of vaccinia virus (VACV)-induced MNTs has never been studied. In this report, VACV-induced MNTs formation process was monitored on a microfluidic chip equipped with a series of side chambers, which protected MNTs from fluidic shear stress. MNTs were formed between susceptible cells and be facilitated by VACV infection through three patterns. The formed MNTs varied with cell migration and virus concentration...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28317765/the-effects-of-temperature-on-the-crystalline-properties-and-resistant-starch-during-storage-of-white-bread
#14
William R Sullivan, Jeff G Hughes, Russell W Cockman, Darryl M Small
Resistant starch (RS) can form during storage of foods, thereby bestowing a variety of potential health benefits. The purpose of the current study has been to determine the influence of storage temperature and time on the crystallinity and RS content of bread. Loaves of white bread were baked and stored at refrigeration, frozen and room temperatures with analysis over a period of zero to seven days. RS determination and X-ray diffraction (XRD) were used to evaluate the influence of storage temperature and time on total crystallinity and RS content...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28317476/myocardial-infarction-pathological-relevance-and-relationship-with-coronary-risk-factors
#15
Aurelio Leone
BACKGROUND: Three types of necrosis characterize MI: coagulation necrosis, typically due to a coronarogenic mechanism, coagulative myocytolysis with formation of contract bands as an effect of sympathetic nervous system and adrenergic stimulation, and colliquative myocytolysis, characterized by myocardial fiber lysis, which is a close result of hydrolytic enzyme activity deriving from the material reaching the infarct area. METHODS: Although a multifactorial etiology may be identified, nevertheless coronary alterations, which are a consequence of atherosclerotic plaque formation and complications with a reduced blood flow supply to the myocardium, are the benchmark of MI...
March 17, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28317066/er%C3%AE-and-gnrh-co-localize-in-the-hypothalamic-neurons-of-the-south-american-plains-vizcacha-lagostomus-maximus-rodentia-caviomorpha
#16
Pablo Ignacio Felipe Inserra, Santiago Elías Charif, Noelia Paula Di Giorgio, Lucía Saucedo, Alejandro Raúl Schmidt, Nicolas Fraunhoffer, Julia Halperin, María Constanza Gariboldi, Noelia Paola Leopardo, Victoria Lux-Lantos, Candela Rocío Gonzalez, Alfredo Daniel Vitullo, Verónica Berta Dorfman
Gonadotropin-releasing hormone (GnRH) is the key regulator of the hypothalamic-pituitary-gonadal axis. Estradiol (E2) affects GnRH synthesis and delivery. Hypothalamic estrogen receptors (ER) modulate GnRH expression acting as transcription factors. The South American plains vizcacha, Lagostomus maximus, is able to ovulate up to 800 oocytes per reproductive cycle, and shows continuous folliculogenesis with pre-ovulatory follicle formation and an ovulatory event at mid-gestation. The aim of this work was to analyze the hypothalamic expression of ER in the vizcacha at different gestational time-points, and its relationship with GnRH expression, serum luteinizing hormone (LH) and E2...
March 19, 2017: Journal of Molecular Histology
https://www.readbyqxmd.com/read/28316258/walking-football-as-sustainable-exercise-for-older-adults-a-pilot-investigation
#17
Peter Reddy, Irundika Dias, Carol Holland, Niyah Campbell, Iaysha Nagar, Luke Connolly, Peter Krustrup, Harry Hubball
The health benefits of playing football and the importance of exercise and social contact for healthy ageing are well established, but few older adults in the UK take enough exercise. Football is popular, flexible in format and draws players into engrossing, effortful and social exercise, but the physical demands of play at full speed may make it unsustainable for some older adults. Restricted to walking pace, will play still be engaging? Will health benefits be retained? Will physical demands remain manageable? This pilot study aims to investigate: (1) the experience of older adults playing walking football every week, is it sustainable and rewarding, (2) the intensity and locomotor pattern of walking football, (3) the scale and nature of walking football health benefits and (4) possible cognitive benefits of playing walking football through measures of processing speed, selective and divided attention and updating and inhibition components of executive function...
March 19, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28315426/vascular-patterning-in-human-heterotopic-ossification
#18
Margaret Cocks, Aditya Mohan, Carolyn A Meyers, Catherine Ding, Benjamin Levi, Edward McCarthy, Aaron W James
Heterotopic ossification (HO, also termed myositis ossificans) is the formation of extra-skeletal bone in muscle and soft tissues. HO is a tissue repair process gone awry, and is a common complication of surgery and traumatic injury. Medical strategies to prevent and treat HO fall well short of addressing the clinical need. Better characterization of the tissues supporting HO is critical to identifying therapies directed against this common and sometimes devastating condition. The physiologic processes of osteogenesis and angiogenesis are highly coupled and interdependent...
March 14, 2017: Human Pathology
https://www.readbyqxmd.com/read/28314181/photocatalytic-degradation-effect-of-malachite-green-and-catalytic-hydrogenation-by-uv-illuminated-ceo2-cdo-multilayered-nanoplatelet-arrays-investigation-of-antifungal-and-antimicrobial-activities
#19
C Maria Magdalane, K Kaviyarasu, J Judith Vijaya, C Jayakumar, M Maaza, B Jeyaraj
CeO2/CdO multi-layered nanoplatelet arrays have been synthesized by sol-gel method at two different temperatures using Citrus limonum fruit extract and the effect of particle size on the photocatalytic performance is studied. The particle size and phases was analysed by X-ray diffraction pattern (XRD) which brought out the formation of cubic phase in the synthesized samples. Field Emission Scanning electron microscopy (FESEM) revealed the surface morphology and made up of cumulative form of platelet shaped arrays with an average size of 10nm...
March 9, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28306173/investigation-of-the-role-of-template-features-on-the-electrically-induced-structure-formation-eisf-for-a-faithful-duplication
#20
Hongmiao Tian, Jinyou Shao, Xiaoliang Chen, Wei Jiang, Li Wang, Yucheng Ding
Electrically induced structure formation (EISF), as a physical approach to fabricate micro/nano-structures, has attracted much attention because of the simple process, low cost, high efficiency and wide applications on electronics, microfluidics, and so forth. Hitherto, the influence of some process parameters, such as voltage, air gap, film thickness, polymer properties, on the polymeric behavior and the structure formation has been explored, neglecting the effects of the template features, which affect the polymer deformation...
March 17, 2017: Electrophoresis
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