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Pauline M Hilt, Pasquale Cardellicchio
Motor inhibition and attentional processing are tightly linked. Recent neurophysiological studies have shown that both processes might rely on similar cognitive and neural mechanisms (Wessel and Aron, Neuron 93:259-280, 2017). However, it remains unclear whether attentional reorientation influences inhibition of a subsequent action. Therefore, we combined two tasks that are commonly used in the motor inhibition and visual attention reorientation field [respectively: the stop-signal task (Logan and Cowan, Psychol Rev 91:295-327, 1984) and the Posner endogenous cueing paradigm (Posner, Q J Exp Psychol 32(1):3-25, 1980)] to investigate how different aspects of visual attention modulate subsequent voluntary inhibition...
March 8, 2018: Psychological Research
Sabine Hilt, Marta M Alirangues Nuñez, Elisabeth S Bakker, Irmgard Blindow, Thomas A Davidson, Mikael Gillefalk, Lars-Anders Hansson, Jan H Janse, Annette B G Janssen, Erik Jeppesen, Timm Kabus, Andrea Kelly, Jan Köhler, Torben L Lauridsen, Wolf M Mooij, Ruurd Noordhuis, Geoff Phillips, Jacqueline Rücker, Hans-Heinrich Schuster, Martin Søndergaard, Sven Teurlincx, Klaus van de Weyer, Ellen van Donk, Arno Waterstraat, Nigel Willby, Carl D Sayer
Submerged macrophytes play a key role in north temperate shallow lakes by stabilizing clear-water conditions. Eutrophication has resulted in macrophyte loss and shifts to turbid conditions in many lakes. Considerable efforts have been devoted to shallow lake restoration in many countries, but long-term success depends on a stable recovery of submerged macrophytes. However, recovery patterns vary widely and remain to be fully understood. We hypothesize that reduced external nutrient loading leads to an intermediate recovery state with clear spring and turbid summer conditions similar to the pattern described for eutrophication...
2018: Frontiers in Plant Science
Evan Maynard, Emily Heath, Michelle Hilts, Andrew Jirasek
This study introduces the first 3D deformable dosimetry system based on x-ray computed tomography (CT) polymer gel dosimetry (PGD) and establishes the setup reproducibility, deformation characteristics and dose response of the system. A N-isopropylacrylamide (NIPAM)-based gel formulation optimized for X-ray CT gel dosimetry was used, with a latex balloon serving as the deformable container and low-density polyethylene and polyvinyl alcohol providing additional oxygen barrier. Deformable gels were irradiated with a 6 MV calibration pattern to determine dosimetric response and a dosimetrically uniform plan to determine the spatial uniformity of the response...
March 8, 2018: Physics in Medicine and Biology
Corinna Kohlmeyer, Maike Klüppel, Gerhard Hilt
The electrophilic ipso-substitution of trimethylsilyl-substituted benzene derivatives into nitrosobenzene derivatives is reported. The optimization of the reaction conditions was performed for moderately electron-deficient, electron-rich and sterically hindered starting materials by varying reaction time, temperature and equivalents of NOBF4. Also, a stable intermediate of the nitrosation reaction could be characterized by 19F NMR which can be assigned to a NO+ adduct with the nitrosobenzene derivative. This complex decomposes upon aqueous workup and liberates the desired nitrosobenzene derivative...
February 27, 2018: Journal of Organic Chemistry
Jan Aaseth, Bjørn Hilt, Geir Bjørklund
Based on toxicological, clinical, and epidemiological knowledge, the present paper reviews the status regarding possible deleterious health effects from occupational exposure to metallic mercury (Hg) in dental practice. Symptoms from the central nervous system are among the health problems that most often are attributed to Hg exposure in dentists and dental nurses working with amalgam. Uncharacteristic symptoms of chronic low-level Hg vapor exposure including weakness, fatigue, and anorexia have been observed in numerous studies of dental personnel...
February 23, 2018: Environmental Research
Grace A Albanese, Laura R Tensa, Emily J Aston, Deborah A Hilt, Brian J Jordan
Coccidiosis is an economically significant disease of poultry caused by species of Eimeria, a parasitic protozoan. Disease can result in poor feed conversion, reduced weight gain, and can lead to the development of necrotic enteritis. For prevention of coccidiosis, poultry are commonly vaccinated with a live, sporulated oocysts mass applied with a vaccination cabinet in the hatchery. Traditionally, coccidia vaccines have been applied by coarse spray in a water based diluent, however, new technology using gel diluents has entered the US market...
February 15, 2018: Poultry Science
Qitang Fan, Liming Liu, Jingya Dai, Tao Wang, Huanxin Ju, Jin Zhao, Julian Kuttner, Gerhard Hilt, J Michael Gottfried, Junfa Zhu
Structural transformations of supramolecular systems triggered by external stimuli maintain great potential for application in the fabrication of molecular storage devices. Using combined ultrahigh vacuum scanning tunneling microscopy (UHV-STM), X-ray photoemission spectroscopy (XPS), and density functional theory (DFT) calculation, we unambiguously observed the surface adatom mediated structural transformation from 4,4''-dibromo-m-terphenyl (DMTP)-based halogen-bonded networks to DMTP-Cu(Ag) coordination networks on Cu(111) and Ag(111) at low temperatures...
February 19, 2018: ACS Nano
Prachi Gupta, Caroline Lacerda, Vinod Patil, Dipti Biswal, Paritosh Wattamwar, J Zach Hilt, Thomas D Dziubla
Poly(β amino ester) polymers have received growing attention in the literature, owing to their ease of synthesis, versatile co-monomer selection, and highly tunable degradation kinetics. As such, they have shown extensive potential in many biomedical applications as well. In this work, it is demonstrated for the first time that PβAE polymers containing primary and secondary amine groups can undergo degradation by primary alcohols via transesterification mechanism. While this work emphasizes an important aspect of solvent compatibility of these networks, it also represents an interesting, simple mechanism for post synthesis drug incorporation, with riboflavin conjugation being demonstrated as a model compound...
June 15, 2017: Journal of Polymer Science. Part A, Polymer Chemistry
Pasquale Cardellicchio, Pauline M Hilt, Etienne Olivier, Luciano Fadiga, Alessandro D'Ausilio
Errors while performing an action are fundamental for learning. During interaction others' errors must be monitored and taken into account to allow joint action coordination and imitation learning. This monitoring relies on an action observation network (AON) mainly based on parietofrontal recurrent circuits. Although different studies suggest that inappropriate actions may rapidly be inhibited during execution, little is known about the modulation of the AON when an action misstep is shown. Here we used single and paired pulse transcranial magnetic stimulation to assess corticospinal excitability, intracortical facilitation and intracortical inhibition at different time intervals (120, 180, 240 ms) after the visual presentation of a motor execution error...
January 29, 2018: Scientific Reports
Eduardo Franzotti Sant'Anna, Mônica Tirre de Souza Araújo, Lincoln Issamu Nojima, Amanda Carneiro da Cunha, Bruno Lopes da Silveira, Mariana Marquezan
INTRODUCTION: In dental practice, low-level laser therapy (LLLT) and high-intensity laser therapy (HILT) are mainly used for dental surgery and biostimulation therapy. Within the Orthodontic specialty, while LLLT has been widely used to treat pain associated with orthodontic movement, accelerate bone regeneration after rapid maxillary expansion, and enhance orthodontic tooth movement, HILT, in turn, has been seen as an alternative for addressing soft tissue complications associated to orthodontic treatment...
November 2017: Dental Press Journal of Orthodontics
Tracy P Trang, Meghan Whalen, Alexandra Hilts-Horeczko, Sarah B Doernberg, Catherine Liu
BACKGROUND: Respiratory syncytial virus (RSV) is a leading cause of viral infections in immunocompromised hosts and is associated with significant morbidity and mortality. In January 2015, our institution switched from aerosolized to oral ribavirin (RBV) for primary treatment of RSV infection among high risk immunocompromised adult patients. The objective of the study was to evaluate the clinical and economic outcomes associated with this switch. METHODS: Retrospective cohort analysis of adult patients diagnosed with RSV infection and treated with RBV between January 1, 2013 and May 31, 2016...
January 23, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
Michelle Wemette, Asante Shipp Hilts, Stephanie R Mack, Yunshu Li, Millicent Eidson, Loretta A Santilli, Trang Nguyen, Guthrie S Birkhead
OBJECTIVE: Services provided by the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) were interrupted in 2012 when Superstorm Sandy struck New York State (NYS). The present study evaluates the impact on WIC providers. DESIGN: A focus group, telephone interviews and anonymous online survey were conducted. Qualitative data were analysed by coding transcribed text into key words and identifying major and minor themes for strengths, challenges and recommendations using national public health preparedness capabilities...
January 10, 2018: Public Health Nutrition
Shuo Tang, Martha Floy, Rohit Bhandari, Manjula Sunkara, Andrew J Morris, Thomas D Dziubla, J Zach Hilt
A novel crosslinker [4,4'-dihydroxybiphenyl diacrylate (44BDA)] was developed, and a series of temperature-responsive hydrogels were synthesized through free radical polymerization of N-isopropylacrylamide (NIPAAm) with 44BDA. The temperature-responsive behavior of the resulting gels was characterized by swelling studies, and the lower critical solution temperature (LCST) of the hydrogels was characterized through differential scanning calorimetry. Increased content of 44BDA led to a decreased swelling ratio and shifted the LCST to lower temperatures...
December 31, 2017: ACS Omega
Andrew L Lakes, Carolyn T Jordan, Prachi T Gupta, David A Puleo, J Zach Hilt, Thomas D Dziubla
Recently, biomaterials have been designed to contain redox-sensitive moieties, such as thiols and disulfides, to impart responsive degradation and/or controlled release. However, due to the high sensitivity of cellular redox-based systems which maintain free-radical homeostasis (e.g. glutathione/glutathione disulfide), if these biomaterials modify the cellular redox environment, they may inadvertently affect cellular compatibility and/or oxidative stress defenses. In this work, we hypothesize that the degradation products of a poly(β-amino ester) (PBAE) hydrogel formed with redox sensitive disulfide (cystamine) crosslinking could serve as a supplement to the environmental cellular antioxidant defenses...
December 28, 2017: Acta Biomaterialia
Travis K Price, Evann E Hilt, Tanaka J Dune, Elizabeth R Mueller, Alan J Wolfe, Linda Brubaker
Urinary tract infection (UTI) is clinically important, given that it is one of the most common bacterial infections in adult women. However, the current understanding of UTI remains based on a now disproven concept that the urinary bladder is sterile. Thus, current standards for UTI diagnosis have significant limitations that may reduce the opportunity to improve patient care. Using data from our work and numerous other peer-reviewed studies, we identified four major limitations to the contemporary UTI description: the language of UTI, UTI diagnostic testing, the Escherichia coli-centric view of UTI, and the colony-forming units (CFU) threshold-based diagnosis...
February 2018: International Urogynecology Journal
Robert Möckel, Jessica Hille, Erik Winterling, Stephan Weidemüller, Tabea Melanie Faber, Gerhard Hilt
An electrochemical access to iodinated aromatic compounds starting from trimethylsilyl-substituted arenes is presented. By design of experiments, highly efficient and mild conditions were identified for a wide range of substrates. A functional group stability test and the synthesis of an important 3-iodobenzylguanidine radiotracer illustrate the scope of this process.
January 8, 2018: Angewandte Chemie
Huawei Liu, Xiaojing Wang, Huaiting Qi, Qian Wang, Yongchao Chen, Qiang Li, Yuying Zhang, Li Qiu, Julia Elise Fontana, Baohong Zhang, Weiling Wang, Yingge Xie
Based on our previous study, cereal crop wheat (Triticum aestivum L.) could be infected by rhizobia Azorhizobium caulinodans ORS571, and form para-nodules with the induction of 2.4-dichlorophenoxyacetic acid, a common plant growth regulator. To enhance this infection and the potential agricultural application, we compared six different infection methods (Direct seed dip; Seed germination dip; Pruned-root dip; Foliar spray; Circum-soil dip; Seed dip and circum-soil dip) for achieving the high efficient infection of A...
2017: PloS One
Ali Abd El-Monsif Thabet, Ahmed Mohamed Elsodany, Kadrya H Battecha, Mansour Abdullah Alshehri, Bassem Refaat
[Purpose] To determine the efficacy of high intensity laser therapy (HILT) versus pulsed electromagnetic field (PEMF) in the treatment of primary dysmenorrhea. [Subjects and Methods] This was a randomized clinical trial that included 52 girls diagnosed with primary dysmenorrhea and who were assigned randomly into two groups of equal numbers. The treatment was three sessions every cycle for three consecutive cycles where group (A) included those participants treated with HILT 15 min/session and group (B) those who were treated with PEMF 30 min/session...
October 2017: Journal of Physical Therapy Science
Ralf C H Aben, Nathan Barros, Ellen van Donk, Thijs Frenken, Sabine Hilt, Garabet Kazanjian, Leon P M Lamers, Edwin T H M Peeters, Jan G M Roelofs, Lisette N de Senerpont Domis, Susanne Stephan, Mandy Velthuis, Dedmer B Van de Waal, Martin Wik, Brett F Thornton, Jeremy Wilkinson, Tonya DelSontro, Sarian Kosten
Methane (CH4 ) strongly contributes to observed global warming. As natural CH4 emissions mainly originate from wet ecosystems, it is important to unravel how climate change may affect these emissions. This is especially true for ebullition (bubble flux from sediments), a pathway that has long been underestimated but generally dominates emissions. Here we show a remarkably strong relationship between CH4 ebullition and temperature across a wide range of freshwater ecosystems on different continents using multi-seasonal CH4 ebullition data from the literature...
November 22, 2017: Nature Communications
Daniëlle C Eindhoven, Alexander D Hilt, Thomas C Zwaan, Martin J Schalij, C Jan Willem Borleffs
Background Following myocardial infarction, medication is, besides lifestyle interventions, the cornerstone treatment to improve survival and minimize the occurrence of new cardiovascular events. Still, data on nationwide medication adherence are scarce. This study assesses medical adherence during one year following myocardial infarction, stratifying per type of infarct, age and gender. Design Retrospective cohort study. Methods In The Netherlands, all inhabitants are by law obliged to have health insurance and all claims data are centrally registered...
January 1, 2017: European Journal of Preventive Cardiology
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