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https://www.readbyqxmd.com/read/28078503/efficacy-of-pulsed-nd-yag-laser-in-the-treatment-of-patients-with-knee-osteoarthritis-a-randomized-controlled-trial
#1
Mohamed Salaheldien Mohamed Alayat, Tarek Helmy Ahmed Aly, Aly Elsayed Mohamed Elsayed, Ammar Suliman Mohamed Fadil
The purpose of this study was to investigate the effects of pulsed Nd:YAG laser plus glucosamine/chondroitin sulfate (GCS) in patients with knee osteoarthritis (KOA) by examining changes in pain and knee function, as well as synovial thickness (ST) and femoral cartilage thickness (FCT). Sixty-seven male patients participated, with a mean (SD) age of 53.85 (4.39) years, weight of 84.01 (4.70) kg, height of 171.51 (3.96) cm, and BMI of 28.56 (1.22). Group 1 was treated with high-intensity laser therapy (HILT), GCS, and exercises (HILT + GCS + EX)...
January 11, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28067969/disseminated-acanthamoeba-infection-in-a-heart-transplant-recipient-treated-successfully-with-a-miltefosine-containing-regimen-case-report-and-review-of-the-literature
#2
Max N Brondfield, Michael J A Reid, Rachel L Rutishauser, Jennifer R Cope, Jevon Tang, Jana M Ritter, Almea Matanock, Ibne Ali, Sarah B Doernberg, Alexandra Hilts-Horeczko, Teresa DeMarco, Liviu Klein, Jennifer M Babik
Disseminated acanthamoebiasis is a rare, often fatal, infection most commonly affecting immunocompromised patients. We report a case involving sinuses, skin, and bone in a 60-year-old woman 5 months after heart transplantation. She improved with a combination of flucytosine, fluconazole, miltefosine, and decreased immunosuppression. To our knowledge, this is the first case of successfully treated disseminated acanthamoebiasis in a heart transplant recipient and only the second successful use of miltefosine for this infection among solid organ transplant recipients...
January 9, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28056401/toxicity-evaluation-of-magnetic-hyperthermia-induced-by-remote-actuation-of-magnetic-nanoparticles-in-3d-micrometastasic-tumor-tissue-analogs-for-triple-negative-breast-cancer
#3
Nathanael A Stocke, Pallavi Sethi, Amar Jyoti, Ryan Chan, Susanne M Arnold, J Zach Hilt, Meenakshi Upreti
Magnetic hyperthermia as a treatment modality is acquiring increased recognition for loco-regional therapy of primary and metastatic lung malignancies by pulmonary delivery of magnetic nanoparticles (MNP). The unique characteristic of magnetic nanoparticles to induce localized hyperthermia in the presence of an alternating magnetic field (AMF) allows for preferential killing of cells at the tumor site. In this study we demonstrate the effect of hyperthermia induced by low and high dose of MNP under the influence of an AMF using 3D tumor tissue analogs (TTA) representing the micrometastatic, perfusion independent stage of triple negative breast cancer (TNBC) that infiltrates the lungs...
December 23, 2016: Biomaterials
https://www.readbyqxmd.com/read/28035662/evaluation-of-accuracy-and-precision-in-polymer-gel-dosimetry
#4
Evan Maynard, Michelle Hilts, Emily Heath, Andrew Jirasek
PURPOSE: To assess the overall reproducibility and accuracy of an x-ray computed tomography (CT) polymer gel dosimetry (PGD) system and investigate what effects the use of generic, inter-batch, and intra-batch gel calibration have on dosimetric and spatial accuracy. METHODS: A N-isopropylacrylamide (NIPAM) based gel formulation optimized for x-ray CT gel dosimetry was used and the results over four different batches of gels were analyzed. All gels were irradiated with three 6 MV beams in a calibration pattern at both the bottom and top of the dosimeter...
December 30, 2016: Medical Physics
https://www.readbyqxmd.com/read/27983779/on-surface-synthesis-and-characterization-of-honeycombene-oligophenylene-macrocycles
#5
Min Chen, Jian Shang, Yongfeng Wang, Kai Wu, Julian Kuttner, Gerhard Hilt, Wolfgang Hieringer, J Michael Gottfried
We report the on-surface formation and characterization of [30]-honeycombene, a cyclotriacontaphenylene, which consists of 30 phenyl rings (C180H120) and has a diameter of 4.0 nm. This shape-persistent, conjugated, and unsubstituted hexagonal hydrocarbon macrocycle was obtained by solvent-free synthesis on a silver (111) single-crystal surface, making solubility-enhancing alkyl side groups unnecessary. Side products include strained macrocycles with square, pentagonal, and heptagonal shape. The molecules were characterized by scanning tunneling microscopy and density functional theory (DFT) calculations...
December 23, 2016: ACS Nano
https://www.readbyqxmd.com/read/27976591/efficacy-of-pulsed-high-intensity-laser-therapy-on-pain-functional-capacity-and-gait-in-children-with-haemophilic-arthropathy
#6
Shamekh Mohamed El-Shamy, Ashraf Abdelaal Mohamed Abdelaal
AIM: The aim of this study was to evaluate the effects of pulsed high-intensity laser therapy (HILT) on pain, functional capacity, and gait in children with haemophilia. METHODS: Thirty children with haemophilia type A with ages ranging from 9 to 13 years were selected for this study. They were assigned randomly, into two equal treatment groups. The laser group received the traditional physical therapy programme plus active laser (total energy of 1500 J through three phases/3 sessions/week), whereas the placebo group received the same physical therapy programme plus placebo laser over three consecutive months...
December 15, 2016: Disability and Rehabilitation
https://www.readbyqxmd.com/read/27942148/the-effects-of-high-intensity-laser-therapy-on-pain-and-function-in-patients-with-knee-osteoarthritis
#7
Gook-Joo Kim, Jioun Choi, Sangyong Lee, Chunbae Jeon, Kwansub Lee
[Purpose] The purpose of this study was to examine the effects of high intensity laser therapy (HILT) on pain and function in patients with knee osteoarthritis. [Subjects and Methods] In this study, an experiment was conducted on 20 subjects who were divided into the control group (n=10), which would receive conservative physical therapy (CPT), and the experimental group (n=10), which would receive effects of high intensity laser therapy after conservative physical therapy. All patients received their respective therapies three times each week over a four-week period...
November 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/27922343/daily-and-trait-rumination-diurnal-cortisol-patterns-in-adolescent-girls
#8
Lori M Hilt, Michael R Sladek, Leah D Doane, Catherine B Stroud
Rumination is a maladaptive form of emotion regulation associated with psychopathology. Research with adults suggests that rumination covaries with diurnal cortisol rhythms, yet this has not been examined among adolescents. Here, we examine the day-to-day covariation between rumination and cortisol, and explore whether trait rumination is associated with alterations in diurnal cortisol rhythms among adolescent girls. Participants (N = 122) provided saliva samples 3 times per day over 3 days, along with daily reports of stress and rumination, questionnaires assessing trait rumination related to peer stress, and diagnostic interviews assessing depression and anxiety...
December 6, 2016: Cognition & Emotion
https://www.readbyqxmd.com/read/27911291/a-metal-free-method-for-producing-mri-contrast-at-amyloid-%C3%AE
#9
Silvia Hilt, Tang Tang, Jeffrey H Walton, Madhu Budamagunta, Izumi Maezawa, Tamás Kálai, Kálmán Hideg, Vikrant Singh, Heike Wulff, Qizhi Gong, Lee-Way Jin, Angelique Louie, John C Voss
Alzheimer's disease (AD) is characterized by depositions of the amyloid-β (Aβ) peptide in the brain. The disease process develops over decades, with substantial neurological loss occurring before a clinical diagnosis of dementia can be rendered. It is therefore imperative to develop methods that permit early detection and monitoring of disease progression. In addition, the multifactorial pathogenesis of AD has identified several potential avenues for AD intervention. Thus, evaluation of therapeutic candidates over lengthy trial periods also demands a practical, noninvasive method for measuring Aβ in the brain...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27908986/draft-genome-sequence-of-a-urinary-isolate-of-lactobacillus-crispatus
#10
Travis K Price, Majed Shaheen, Laurynas Kalesinskas, Kema Malki, Evann E Hilt, Catherine Putonti, Alan J Wolfe
While Lactobacillus crispatus contributes to the stability of normal vaginal microbiota, its role in urinary health remains unclear. As part of an on-going attempt to characterize the female urinary microbiota, we report the genome sequence of an L. crispatus strain isolated from a woman displaying no lower urinary tract symptoms.
December 1, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27903105/dsm-5-%C3%A2-pocket-guide-for-child-and-adolescent-mental-healthby-robert-j-hilt-m-d-f-a-a-p-and-abraham-m-nussbaum-m-d-f-a-p-a-washington-d-c-american-psychiatric-association-publishing-2016-355-pp-65-00-paperback
#11
https://www.readbyqxmd.com/read/27861551/genomes-of-gardnerella-strains-reveal-an-abundance-of-prophages-within-the-bladder-microbiome
#12
Kema Malki, Jason W Shapiro, Travis K Price, Evann E Hilt, Krystal Thomas-White, Trina Sircar, Amy B Rosenfeld, Gina Kuffel, Michael J Zilliox, Alan J Wolfe, Catherine Putonti
Bacterial surveys of the vaginal and bladder human microbiota have revealed an abundance of many similar bacterial taxa. As the bladder was once thought to be sterile, the complex interactions between microbes within the bladder have yet to be characterized. To initiate this process, we have begun sequencing isolates, including the clinically relevant genus Gardnerella. Herein, we present the genomic sequences of four Gardnerella strains isolated from the bladders of women with symptoms of urgency urinary incontinence; these are the first Gardnerella genomes produced from this niche...
2016: PloS One
https://www.readbyqxmd.com/read/27856579/draft-genome-sequence-for-a-urinary-isolate-of-nosocomiicoccus-ampullae
#13
Evann E Hilt, Travis K Price, Katherine Diebel, Catherine Putonti, Alan J Wolfe
A draft genome sequence for a urinary isolate of Nosocomiicoccus ampullae (UMB0853) was investigated. The size of the genome was 1,578,043 bp, with an observed G+C content of 36.1%. Annotation revealed 10 rRNA sequences, 40 tRNA genes, and 1,532 protein-coding sequences. Genome coverage was 727× and consisted of 32 contigs, with an N50 of 109,831 bp.
November 17, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27777649/genome-sequences-and-annotation-of-two-urinary-isolates-of-e-coli
#14
Travis K Price, Arya Mehrtash, Laurynas Kalesinskas, Kema Malki, Evann E Hilt, Catherine Putonti, Alan J Wolfe
The genus Escherichia includes pathogens and commensals. Bladder infections (cystitis) result most often from colonization of the bladder by uropathogenic E. coli strains. In contrast, a poorly defined condition called asymptomatic bacteriuria results from colonization of the bladder with E. coli strains without symptoms. As part of an on-going attempt to identify and characterize the newly discovered female urinary microbiota, we report the genome sequences and annotation of two urinary isolates of E. coli: one (E78) was isolated from a female patient who self-reported cystitis; the other (E75) was isolated from a female patient who reported that she did not have symptoms of cystitis...
2016: Standards in Genomic Sciences
https://www.readbyqxmd.com/read/27771242/incorporating-three-dimensional-ultrasound-into-permanent-breast-seed-implant-brachytherapy-treatment-planning
#15
Daniel Morton, Deidre Batchelar, Michelle Hilts, Tanya Berrang, Juanita Crook
PURPOSE: Planning permanent breast seed implant (PBSI) brachytherapy using CT alone may reduce treatment accuracy because of differences in seroma visualization compared with ultrasound (US). This study evaluates dosimetric effects of seroma delineation in PBSI and the potential impact of incorporating three-dimensional (3D) US into PBSI treatment planning. METHODS AND MATERIALS: Spatially coregistered CT and 3D US images from 10 patients were retrospectively analyzed to simulate the PBSI procedure...
October 19, 2016: Brachytherapy
https://www.readbyqxmd.com/read/27636024/farmers-mental-health-a-longitudinal-sibling-comparison-the-hunt-study-norway
#16
Magnhild Oust Torske, Johan Håkon Bjørngaard, Bjørn Hilt, David Glasscock, Steinar Krokstad
OBJECTIVE: Studies of the mental health of farmers have been largely cross-sectional and possibly confounded. We performed a prospective cohort study as well as a sibling comparison to control for unmeasured confounding. METHODS: Our study included 76 583 participants aged ≥19 years from the Nord-Trøndelag Health Study [HUNT1 (1984-1986), HUNT2 (1995-1997) and HUNT3 (2006-2008)]. We used the Anxiety and Depression Index (ADI) and the Hospital Anxiety and Depression Scale (HADS) to measure symptoms of mental distress...
September 16, 2016: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/27624513/collaborative-care-for-adolescents-with-persistent-postconcussive-symptoms-a-randomized-trial
#17
Carolyn A McCarty, Douglas Zatzick, Elizabeth Stein, Jin Wang, Robert Hilt, Frederick P Rivara
BACKGROUND AND OBJECTIVES: Postconcussive and co-occurring psychological symptoms are not uncommon after sports-related concussion and are associated with functional impairment and societal costs. There is no evidence-based treatment targeting postconcussive symptoms in children and adolescents. The goal of this study was to test a collaborative care intervention model with embedded cognitive-behavioral therapy, care management, and psychopharmacological consultation. We hypothesized that patients in collaborative care would demonstrate greater reductions in postconcussive, depressive, and anxiety symptoms and improvement in functioning over the course of 6 months, compared with usual care control...
October 2016: Pediatrics
https://www.readbyqxmd.com/read/27613351/integrated-care-for-pediatric-substance-abuse
#18
REVIEW
Rebecca P Barclay, Robert J Hilt
Integrated care is a way to improve the prevention, identification, and treatment of mental health difficulties, including substance abuse, in pediatric care. The pediatrician's access, expertise in typical development, focus on prevention, and alignment with patients and families can allow successful screening, early intervention, and referral to treatment. Successful integrated substance abuse care for youth is challenged by current reimbursement systems, information exchange, and provider role adjustment issues, but these are being addressed as comfort with this care form and resources to support its development grow...
October 2016: Child and Adolescent Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/27521615/targeted-iron-oxide-nanoparticles-for-the-enhancement-of-radiation-therapy
#19
Anastasia K Hauser, Mihail I Mitov, Emily F Daley, Ronald C McGarry, Kimberly W Anderson, J Zach Hilt
To increase the efficacy of radiation, iron oxide nanoparticles can be utilized for their ability to produce reactive oxygen species (ROS). Radiation therapy promotes leakage of electrons from the electron transport chain and leads to an increase in mitochondrial production of the superoxide anion which is converted to hydrogen peroxide by superoxide dismutase. Iron oxide nanoparticles can then catalyze the reaction from hydrogen peroxide to the highly reactive hydroxyl radical. Therefore, the overall aim of this project was to utilize iron oxide nanoparticles conjugated to a cell penetrating peptide, TAT, to escape lysosomal encapsulation after internalization by cancer cells and catalyze hydroxyl radical formation...
October 2016: Biomaterials
https://www.readbyqxmd.com/read/27492791/lewis-acids-as-activators-in-cbs-catalysed-diels-alder-reactions-distortion-induced-lewis-acidity-enhancement-of-sncl4
#20
Alexander R Nödling, Robert Möckel, Ralf Tonner, Gerhard Hilt
The effect of several Lewis acids on the CBS catalyst (named after Corey, Bakshi and Shibata) was investigated in this study. While (2) H NMR spectroscopic measurements served as gauge for the activation capability of the Lewis acids, in situ FT-IR spectroscopy was employed to assess the catalytic activity of the Lewis acid oxazaborolidine complexes. A correlation was found between the Δδ((2) H) values and rate constants kDA , which indicates a direct translation of Lewis acidity into reactivity of the Lewis acid-CBS complexes...
September 5, 2016: Chemistry: a European Journal
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