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Justin Michael, Daniel Morton, Deidre Batchelar, Michelle Hilts, Juanita Crook, Aaron Fenster
PURPOSE: Permanent breast seed implantation (PBSI) is a promising radiotherapy technique for early-stage breast cancer, completed in a single visit by permanently implanting 103 Pd seeds using needles inserted through a template and guided by 2D ultrasound (US). However, operator dependence has been highlighted as a limitation of this procedure. Consequently, we propose and have developed an intraoperative guidance system using 3D US and an instrumented mechanical arm to provide intraoperative 3D imaging and needle template tracking...
May 23, 2018: Medical Physics
Qitang Fan, Simon Werner, Jalmar Tschakert, Daniel Ebeling, Andre Schirmeisen, Gerhard Hilt, Wolfgang Hieringer, J Michael Gottfried
Aromatic C-H bond activation has attracted much attention due to its versatile applications in the synthesis of aryl-containing chemicals. The major challenge lies in the minimization of the activation barrier and maximization of the regioselectivity. Here, we report the highly selective activation of the central aromatic C-H bond in meta-aryne species anchored to a copper surface, which catalyzes the C-H bond dissociation. Two prototype molecules, i.e., 4',6'-dibromo-meta-terphenyl and 3',5'-dibromo-ortho-terphenyl have been employed to perform C-C coupling reactions on Cu(111)...
May 11, 2018: Journal of the American Chemical Society
Matthieu Casteran, Pauline M Hilt, France Mourey, Patrick Manckoundia, Robert French, Elizabeth Thomas
In this study, we compared key temporal points in the whole body pointing movement of healthy aging and young subjects. During this movement, subject leans forward from a standing position to reach a target. As it involves forward inclination of the trunk, the movement creates a risk for falling. We examined two strategic time points during the task-first, the crossover point where the velocity of the center of mass (CoM) in the vertical dimension outstripped the velocity in the anteroposterior dimension and secondly, the time to peak of the CoM velocity profile...
May 5, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Yingxia Wen, Hung V Trinh, Christine E Linton, Chiara Tani, Nathalie Norais, DeeAnn Martinez-Guzman, Priyanka Ramesh, Yide Sun, Frank Situ, Selen Karaca-Griffin, Christopher Hamlin, Sayali Onkar, Sai Tian, Susan Hilt, Padma Malyala, Rushit Lodaya, Ning Li, Gillis Otten, Giuseppe Palladino, Kristian Friedrich, Yukti Aggarwal, Celia LaBranche, Ryan Duffy, Xiaoying Shen, Georgia D Tomaras, David C Montefiori, William Fulp, Raphael Gottardo, Brian Burke, Jeffrey B Ulmer, Susan Zolla-Pazner, Hua-Xin Liao, Barton F Haynes, Nelson L Michael, Jerome H Kim, Mangala Rao, Robert J O'Connell, Andrea Carfi, Susan W Barnett
The RV144 Phase III clinical trial with ALVAC-HIV prime and AIDSVAX B/E subtypes CRF01_AE (A244) and B (MN) gp120 boost vaccine regime in Thailand provided a foundation for the future development of improved vaccine strategies that may afford protection against the human immunodeficiency virus type 1 (HIV-1). Results from this trial showed that immune responses directed against specific regions V1V2 of the viral envelope (Env) glycoprotein gp120 of HIV-1, were inversely correlated to the risk of HIV-1 infection...
2018: PloS One
Sherry Gao, Robert W Hilts, Matthew S Ross, Sarah A Styler
No abstract text is available yet for this article.
April 25, 2018: Analytical and Bioanalytical Chemistry
Justyna Wyszyńska, Monika Bal-Bocheńska
OBJECTIVE: The aim of this study was to evaluate the efficacy of high-intensity laser therapy (HILT) in the treatment of knee osteoarthritis (OA). BACKGROUND: Due to increased number of randomized controlled trials evaluating efficiency of HILT in patients with knee OA, there was a need to present them in the form of systematic review. METHODS: The search includes the databases as well as a manual search until August, 2017. The quality of the selected articles was determined in accordance with the revised guidelines of the CONSORT statement...
April 24, 2018: Photomedicine and Laser Surgery
Krystal Thomas-White, Samuel C Forster, Nitin Kumar, Michelle Van Kuiken, Catherine Putonti, Mark D Stares, Evann E Hilt, Travis K Price, Alan J Wolfe, Trevor D Lawley
Metagenomic analyses have indicated that the female bladder harbors an indigenous microbiota. However, there are few cultured reference strains with sequenced genomes available for functional and experimental analyses. Here we isolate and genome-sequence 149 bacterial strains from catheterized urine of 77 women. This culture collection spans 78 species, representing approximately two thirds of the bacterial diversity within the sampled bladders, including Proteobacteria, Actinobacteria, and Firmicutes. Detailed genomic and functional comparison of the bladder microbiota to the gastrointestinal and vaginal microbiotas demonstrates similar vaginal and bladder microbiota, with functional capacities that are distinct from those observed in the gastrointestinal microbiota...
April 19, 2018: Nature Communications
Pauline M Hilt, Ioannis Delis, Thierry Pozzo, Bastien Berret
The modular control hypothesis suggests that motor commands are built from precoded modules whose specific combined recruitment can allow the performance of virtually any motor task. Despite considerable experimental support, this hypothesis remains tentative as classical findings of reduced dimensionality in muscle activity may also result from other constraints (biomechanical couplings, data averaging or low dimensionality of motor tasks). Here we assessed the effectiveness of modularity in describing muscle activity in a comprehensive experiment comprising 72 distinct point-to-point whole-body movements during which the activity of 30 muscles was recorded...
2018: Frontiers in Computational Neuroscience
Banu Ordahan, Ali Yavuz Karahan, Ercan Kaydok
We aimed to compare the efficacy of low-level laser therapy (LLLT) and high-intensity laser therapy (HILT) in the treatment of plantar fasciitis (PF). Seventy patients were randomized into either the LLLT (8 men, 27 women; mean age 48.65 ± 10.81 years) or HILT (7 men, 28 women; mean age 48.73 ± 11.41 years) groups. LLLT (904 nm) and HILT (1064 nm) were performed three times per week, over a period of 3 weeks. Each treatment combined with silicone insole and stretching exercises. Patients' pain and functional status were evaluated with Visual Analog Scale, Heel Tenderness Index, and Foot and Ankle Outcome Score before and after treatment...
April 7, 2018: Lasers in Medical Science
Lúcio Frigo, Joseli Maria Cordeiro, Giovani Marino Favero, Durnavei Augusto Maria, Ernesto Cesar Pinto Leal-Junior, Jon Joensen, Jan Magnus Bjordal, Denise Carvalho Roxo, Rodrigo Labat Marcos, Rodrigo Alvaro Brandão Lopes-Martins
It is well established that laser phototherapy (LP) is contraindicated directly over cancer cells, due to its bio modulatory effects in cell and blood vessel proliferation. The aim of the present study was to analyze the influence of typical low-level laser therapy (LLLT) and high intensity laser therapy (HILT) and an in-between dose of 9 J on collagen fibers and blood vessels content in melanoma tumors (B16F10) implanted in mice. Melanoma tumor cells were injected in male Balb C mice which were distributed in four groups: control (no irradiated) or irradiated by 3, 9, or 21 J (150; 450, or 1050 J/cm2 )...
April 5, 2018: Lasers in Medical Science
Pauline M Hilt, Pasquale Cardellicchio
Motor inhibition and attentional processing are tightly linked. Recent neurophysiological studies have shown that both processes might rely on similar cognitive and neural mechanisms (Wessel and Aron, Neuron 93:259-280, 2017). However, it remains unclear whether attentional reorientation influences inhibition of a subsequent action. Therefore, we combined two tasks that are commonly used in the motor inhibition and visual attention reorientation field [respectively: the stop-signal task (Logan and Cowan, Psychol Rev 91:295-327, 1984) and the Posner endogenous cueing paradigm (Posner, Q J Exp Psychol 32(1):3-25, 1980)] to investigate how different aspects of visual attention modulate subsequent voluntary inhibition...
March 8, 2018: Psychological Research
Sabine Hilt, Marta M Alirangues Nuñez, Elisabeth S Bakker, Irmgard Blindow, Thomas A Davidson, Mikael Gillefalk, Lars-Anders Hansson, Jan H Janse, Annette B G Janssen, Erik Jeppesen, Timm Kabus, Andrea Kelly, Jan Köhler, Torben L Lauridsen, Wolf M Mooij, Ruurd Noordhuis, Geoff Phillips, Jacqueline Rücker, Hans-Heinrich Schuster, Martin Søndergaard, Sven Teurlincx, Klaus van de Weyer, Ellen van Donk, Arno Waterstraat, Nigel Willby, Carl D Sayer
Submerged macrophytes play a key role in north temperate shallow lakes by stabilizing clear-water conditions. Eutrophication has resulted in macrophyte loss and shifts to turbid conditions in many lakes. Considerable efforts have been devoted to shallow lake restoration in many countries, but long-term success depends on a stable recovery of submerged macrophytes. However, recovery patterns vary widely and remain to be fully understood. We hypothesize that reduced external nutrient loading leads to an intermediate recovery state with clear spring and turbid summer conditions similar to the pattern described for eutrophication...
2018: Frontiers in Plant Science
E Maynard, E Heath, M Hilts, A Jirasek
This study introduces the first 3D deformable dosimetry system based on x-ray computed tomography (CT) polymer gel dosimetry and establishes the setup reproducibility, deformation characteristics and dose response of the system. A N-isopropylacrylamide (NIPAM)-based gel formulation optimized for x-ray CT gel dosimetry was used, with a latex balloon serving as the deformable container and low-density polyethylene and polyvinyl alcohol providing additional oxygen barrier. Deformable gels were irradiated with a 6 MV calibration pattern to determine dosimetric response and a dosimetrically uniform plan to determine the spatial uniformity of the response...
March 29, 2018: Physics in Medicine and Biology
Corinna Kohlmeyer, Maike Klüppel, Gerhard Hilt
The electrophilic ipso-substitution of trimethylsilyl-substituted benzene derivatives into nitrosobenzene derivatives is reported. The optimization of the reaction conditions was performed for moderately electron-deficient, electron-rich, and sterically hindered starting materials by varying reaction time, temperature, and equivalents of NOBF4 . Also, a stable intermediate of the nitrosation reaction could be characterized by 19 F NMR which can be assigned to a NO+ adduct with the nitrosobenzene derivative...
April 6, 2018: Journal of Organic Chemistry
Jan Aaseth, Bjørn Hilt, Geir Bjørklund
Based on toxicological, clinical, and epidemiological knowledge, the present paper reviews the status regarding possible deleterious health effects from occupational exposure to metallic mercury (Hg) in dental practice. Symptoms from the central nervous system are among the health problems that most often are attributed to Hg exposure in dentists and dental nurses working with amalgam. Uncharacteristic symptoms of chronic low-level Hg vapor exposure including weakness, fatigue, and anorexia have been observed in numerous studies of dental personnel...
July 2018: Environmental Research
Grace A Albanese, Laura R Tensa, Emily J Aston, Deborah A Hilt, Brian J Jordan
Coccidiosis is an economically significant disease of poultry caused by species of Eimeria, a parasitic protozoan. Disease can result in poor feed conversion, reduced weight gain, and can lead to the development of necrotic enteritis. For prevention of coccidiosis, poultry are commonly vaccinated with a live, sporulated oocysts mass applied with a vaccination cabinet in the hatchery. Traditionally, coccidia vaccines have been applied by coarse spray in a water based diluent, however, new technology using gel diluents has entered the US market...
May 1, 2018: Poultry Science
Qitang Fan, Liming Liu, Jingya Dai, Tao Wang, Huanxin Ju, Jin Zhao, Julian Kuttner, Gerhard Hilt, J Michael Gottfried, Junfa Zhu
Structural transformations of supramolecular systems triggered by external stimuli maintain great potential for application in the fabrication of molecular storage devices. Using combined ultrahigh vacuum scanning tunneling microscopy, X-ray photoemission spectroscopy, and density functional theory calculations, we observed the surface adatom mediated structural transformation from 4,4''-dibromo- m-terphenyl (DMTP)-based halogen-bonded networks to DMTP-Cu(Ag) coordination networks on Cu(111) and Ag(111) at low temperatures...
March 27, 2018: ACS Nano
Prachi Gupta, Caroline Lacerda, Vinod Patil, Dipti Biswal, Paritosh Wattamwar, J Zach Hilt, Thomas D Dziubla
Poly(β amino ester) polymers have received growing attention in the literature, owing to their ease of synthesis, versatile co-monomer selection, and highly tunable degradation kinetics. As such, they have shown extensive potential in many biomedical applications as well. In this work, it is demonstrated for the first time that PβAE polymers containing primary and secondary amine groups can undergo degradation by primary alcohols via transesterification mechanism. While this work emphasizes an important aspect of solvent compatibility of these networks, it also represents an interesting, simple mechanism for post synthesis drug incorporation, with riboflavin conjugation being demonstrated as a model compound...
June 15, 2017: Journal of Polymer Science. Part A, Polymer Chemistry
Pasquale Cardellicchio, Pauline M Hilt, Etienne Olivier, Luciano Fadiga, Alessandro D'Ausilio
Errors while performing an action are fundamental for learning. During interaction others' errors must be monitored and taken into account to allow joint action coordination and imitation learning. This monitoring relies on an action observation network (AON) mainly based on parietofrontal recurrent circuits. Although different studies suggest that inappropriate actions may rapidly be inhibited during execution, little is known about the modulation of the AON when an action misstep is shown. Here we used single and paired pulse transcranial magnetic stimulation to assess corticospinal excitability, intracortical facilitation and intracortical inhibition at different time intervals (120, 180, 240 ms) after the visual presentation of a motor execution error...
January 29, 2018: Scientific Reports
Eduardo Franzotti Sant'Anna, Mônica Tirre de Souza Araújo, Lincoln Issamu Nojima, Amanda Carneiro da Cunha, Bruno Lopes da Silveira, Mariana Marquezan
INTRODUCTION: In dental practice, low-level laser therapy (LLLT) and high-intensity laser therapy (HILT) are mainly used for dental surgery and biostimulation therapy. Within the Orthodontic specialty, while LLLT has been widely used to treat pain associated with orthodontic movement, accelerate bone regeneration after rapid maxillary expansion, and enhance orthodontic tooth movement, HILT, in turn, has been seen as an alternative for addressing soft tissue complications associated to orthodontic treatment...
November 2017: Dental Press Journal of Orthodontics
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