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Creatine monohydrate

Scott C Forbes, Nathan Sletten, Cody Durrer, Étienne Myette-Cote, Darren Candow, Jonathan P Little
High-intensity interval training (HIIT) has been shown to improve cardiorespiratory fitness, performance, body composition, and insulin sensitivity. Creatine (Cr) supplementation may augment responses to HIIT, leading to even greater physiological adaptations. The purpose of this study was to determine the effects of four weeks of HIIT (three sessions/week) combined with Cr supplementation in recreationally active females. Seventeen females (age = 23 ± 4 yrs; BMI = 23.4 ± 2.4) were randomly assigned to either Cr (Cr; 0...
October 21, 2016: International Journal of Sport Nutrition and Exercise Metabolism
Nari Ahn, Yea Hyun Leem, Morimasa Kato, Hyukki Chang
PURPOSE: The effects of creatine and exercise on chronic stress-induced depression are unclear. In the present study, we identified the effects of 4-week supplementation of creatine monohydrate and/or exercise on antidepressant behavior and raphe 5-HT expression in a chronic mild stress-induced depressed mouse model. METHODS: Seven-week-old male C57BL/6 mice (n=48) were divided randomly into 5 groups: (1) non-stress control (CON, n=10), (2) stress control (ST-CON, n=10), (3) stress and creatine intake (ST-Cr, n=10), (4) stress and exercise (ST-Ex, n=9), and (5) combined stress, exercise, and creatine intake (ST-Cr+Ex, n=9)...
September 2016: Journal of Exercise Nutrition & Biochemistry
Asghar Rahmani, Khairollah Asadollahi, Kourosh Soleimannejad, Zahra Khalighi, Yosouf Mohsenzadeh, Ruhollah Hemati, Atefeh Moradkhani, Ghobad Abangah
BACKGROUND: Creatine monohydrate has beneficial effects on serum glucose. This study aimed to investigate the effects of creatine on serum biochemical markers and permeability of coronary arteries among diabetic rats. MATERIAL AND METHODS: 32 Wistar rats, which weighed 150-200 grams were randomly divided into 4 groups including: group I, control; group II, creatine monohydrate; group III, diabetic rats; and group IV, diabetic rats + creatine. Creatine monohydrate was applied by 400 mg/kg/daily for 5 months...
September 2016: Annals of Clinical and Laboratory Science
Wolfgang Oertel, Jörg B Schulz
Over a period of more than 50 years, the symptomatic treatment of the motor symptoms of Parkinson disease (PD) has been optimized using pharmacotherapy, deep brain stimulation, and physiotherapy. The arsenal of pharmacotherapies includes L-Dopa, several dopamine agonists, inhibitors of monoamine oxidase (MAO)-B and catechol-o-methyltransferase (COMT), and amantadine. In the later course of the disease, motor complications occur, at which stage different oral formulations of L-Dopa or dopamine agonists with long half-life, a transdermal application or parenteral pumps for continuous drug supply can be subscribed...
October 2016: Journal of Neurochemistry
Eric C Bredahl, David Hydock
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Razia Allahyar, Atif Akbar, Furhan Iqbal
BACKGROUND: Research findings made over the last few years have highlighted the important role of creatine (Cr) in health and disease. However, limited information is available regarding the effect of Cr supplementation on cognation. Present study was designed to determine the effect of variable doses of Cr (1% and 3%) on selected parameters of female albino mice behaviour. METHODS: Following weaning, on 20th postnatal day, female albino mice were divided into three groups on the basis of dietary supplementation...
June 27, 2016: Acta Neuropsychiatrica
Farajollah Hemati, Asghar Rahmani, Khairollah Asadollahi, Koroush Soleimannejad, Zahra Khalighi
BACKGROUND: Previous studies have reported endothelial dysfunction and inflammatory cytokine in heart failure patients (HF). OBJECTIVES: The purpose of this study was to determine the effects of creatine monohydrate and exercise on inflammatory and endothelial dysfunction markers among HF patients. PATIENTS AND METHODS: One hundred patients were prospectively randomized into two groups: Intervention group which received 5 grams/day creatine monohydrate and exercised for 8 weeks; and control group which did not receive any interventions...
March 2016: Asian Journal of Sports Medicine
L Zhang, X D Zhu, X F Wang, J L Li, F Gao, G H Zhou
Two trials were conducted to investigate the individual and combined effects of in-ovo injection of creatine monohydrate ( CMH: ) and glucose on the somatic characteristics and energy status of broiler embryos and hatchlings and the growth performance of chicks during the first wk posthatch. In trial 1, 550 17.5-day-old living, fertile eggs were randomly assigned to 1 of 5 treatment groups, including 1) a noninjected control, 2) a 0.4 mL diluent-injected control, or 0.4 mL diluents containing 3) 6 mg CMH, 4) 25 mg glucose, or 5) a combination of 6 mg CMH and 25 mg glucose (identified as CMH+G: )...
October 1, 2016: Poultry Science
Elfego Galvan, Dillon K Walker, Sunday Y Simbo, Ryan Dalton, Kyle Levers, Abigail O'Connor, Chelsea Goodenough, Nicholas D Barringer, Mike Greenwood, Christopher Rasmussen, Stephen B Smith, Steven E Riechman, James D Fluckey, Peter S Murano, Conrad P Earnest, Richard B Kreider
BACKGROUND: Creatine monohydrate (CrM) and nitrate are popular supplements for improving exercise performance; yet have not been investigated in combination. We performed two studies to determine the safety and exercise performance-characteristics of creatine nitrate (CrN) supplementation. METHODS: Study 1 participants (N = 13) ingested 1.5 g CrN (CrN-Low), 3 g CrN (CrN-High), 5 g CrM or a placebo in a randomized, crossover study (7d washout) to determine supplement safety (hepatorenal and muscle enzymes, heart rate, blood pressure and side effects) measured at time-0 (unsupplemented), 30-min, and then hourly for 5-h post-ingestion...
2016: Journal of the International Society of Sports Nutrition
Douglas G Kondo, Lauren N Forrest, Xianfeng Shi, Young-Hoon Sung, Tracy L Hellem, Rebekah S Huber, Perry F Renshaw
Major depressive disorder (MDD) often begins during adolescence and is projected to become the leading cause of global disease burden by the year 2030. Yet, approximately 40 % of depressed adolescents fail to respond to standard antidepressant treatment with a selective serotonin reuptake inhibitor (SSRI). Converging evidence suggests that depression is related to brain mitochondrial dysfunction. Our previous studies of MDD in adult and adolescent females suggest that augmentation of SSRI pharmacotherapy with creatine monohydrate (CM) may improve MDD outcomes...
August 2016: Amino Acids
Sujung Yoon, Jieun E Kim, Jaeuk Hwang, Tae-Suk Kim, Hee Jin Kang, Eun Namgung, Soonhyun Ban, Subin Oh, Jeongwon Yang, Perry F Renshaw, In Kyoon Lyoo
BACKGROUND: Creatine monohydrate (creatine) augmentation has the potential to accelerate the clinical responses to and enhance the overall efficacy of selective serotonin reuptake inhibitor treatment in women with major depressive disorder (MDD). Although it has been suggested that creatine augmentation may involve the restoration of brain energy metabolism, the mechanisms underlying its antidepressant efficacy are unknown. METHODS: In a randomized, double-blind, placebo-controlled trial, 52 women with MDD were assigned to receive either creatine augmentation or placebo augmentation of escitalopram; 34 subjects participated in multimodal neuroimaging assessments at baseline and week 8...
September 15, 2016: Biological Psychiatry
Rahman Rahimi, Bahman Mirzaei, Farhad Rahmani-Nia, Zivar Salehi
BACKGROUND: Creatine monohydrate (CrM) has been shown to be beneficial to health due to its antioxidant potential. Strenuous exercise is associated with oxidative stress, which could lead to apoptosis. We investigated the ability of CrM in amelioration of apoptosis induced by incremental aerobic exercise (AE) to exhaustion in young athletes. MATERIALS AND METHODS: In a placebo-controlled, double-blind, randomized, parallel study, 31 young athletes (age 19.52 ± 2...
August 2015: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
Shahid Iqbal, Muhammad Ali, Furhan Iqbal
IL-6 has been reported to have neuroprotective effects against cerebral ischemia while IL-8 is a pro inflammatory cytokine structurally related to interleukin-1 family. In the present study, we tried to determine whether 2% Creatine monohydrate supplementation for variable duration influence the IL-6 and 18 concentrations in the serum of male albino mouse following right common carotid artery ligation and hypoxia (8% oxygen) for 25 minutes. Our result revealed that serum concentration of IL6 (P=0.0001) as well as IL-18 (P=0...
November 2015: Pakistan Journal of Pharmaceutical Sciences
Sylvia Stockler-Ipsiroglu, Delia Apatean, Roberta Battini, Suzanne DeBrosse, Kimberley Dessoffy, Simon Edvardson, Florian Eichler, Katherine Johnston, David M Koeller, Sonia Nouioua, Meriem Tazir, Ashok Verma, Monica D Dowling, Klaas J Wierenga, Andrea M Wierenga, Victor Zhang, Lee-Jun C Wong
BACKGROUND: Arginine:glycine aminotransferase (AGAT) (GATM) deficiency is an autosomal recessive inborn error of creative synthesis. OBJECTIVE: We performed an international survey among physicians known to treat patients with AGAT deficiency, to assess clinical characteristics and long-term outcomes of this ultra-rare condition. RESULTS: 16 patients from 8 families of 8 different ethnic backgrounds were included. 1 patient was asymptomatic when diagnosed at age 3 weeks...
December 2015: Molecular Genetics and Metabolism
Tracy L Hellem, Young-Hoon Sung, Xian-Feng Shi, Marjorie A Pett, Gwen Latendresse, Jubel Morgan, Rebekah S Huber, Danielle Kuykendall, Kelly J Lundberg, Perry F Renshaw
OBJECTIVE: Depression among methamphetamine users is more prevalent in females than males, but gender-specific treatment options for this comorbidity have not been described. Reduced brain phosphocreatine levels have been shown to be lower in female methamphetamine users compared to males, and, of relevance, studies have demonstrated an association between treatment-resistant depression and reduced brain phosphocreatine concentrations. The nutritional supplement creatine monohydrate has been reported to reduce symptoms of depression in female adolescents and adults taking antidepressants, as well as to increase brain phosphocreatine in healthy volunteers...
2015: Journal of Dual Diagnosis
Eric T Trexler, Abbie E Smith-Ryan, Erica J Roelofs, Katie R Hirsch, Adam M Persky, Meredith G Mock
The purpose of this study was to determine the effect of 5 days of creatine (CRE) loading alone or in combination with caffeine anhydrous (CAF) or coffee (COF) on upper-body and lower-body strength and sprint performance. Physically active males (n = 54; mean ± SD; age = 20.1 ± 2.1 years; weight = 78.8 ± 8.8 kg) completed baseline testing, consisting of 1 repetition maximum (1RM) and repetitions to fatigue with 80% 1RM for bench press and leg press, followed by a repeated sprint test of five, 10-second sprints separated by 60-second rest on a cycle ergometer to determine peak power (PP) and total power (TP)...
May 2016: Journal of Strength and Conditioning Research
X F Wang, X D Zhu, Y J Li, Y Liu, J L Li, F Gao, G H Zhou, L Zhang
This experiment was to evaluate the effect of dietary supplementation with creatine monohydrate (CMH) during the finishing period on the muscle lipid peroxidation and antioxidant capacity of broilers that experienced transport stress in summer. A total of 320 male Arbor Acres broilers (28 d in age) were randomly allotted to 3 dietary treatments including a basal control diet without additional CMH (160 birds), or with 600 (80 birds) or 1,200 mg/kg (80 birds) CMH for 14 d. On the morning of d 42, after an 8-h fast, the birds fed the basal diets were divided into 2 equal groups, and all birds in the 4 groups of 80 birds were transported according to the following protocols: 1) a 0...
November 2015: Poultry Science
Rafael Deminice, Alceu Afonso Jordao
Objective The study was to investigate the effects of creatine (Cr) supplementation on oxidative stress markers and anaerobic performance in rats. Methods Sixty-four rats (Wistar) were divided into two groups: C, anaerobic exercised group (n = 32) and Cr, anaerobic exercised group supplemented with creatine (n = 32). Cr supplementation consisted of the addition of 2% Cr monohydrate to the diet. After 28 days, the rats performed acute exercise (6 × 30 seconds of vertical jumps in the water with 30 seconds rest and 50% of total body weight load attached in the back)...
June 17, 2015: Redox Report: Communications in Free Radical Research
Uri Levental, Yuly Bersudsky, Tzvi Dwalatzky, Vladimir Lerner, Sophie Medina, Joseph Levine
BACKGROUND: The effects of creatine on brain metabolism and the potential cognitive enhancing properties of this compound raise the possibility of developing a new augmentation therapeutic strategy in schizophrenia especially in patients demonstrating negative and cognitive symptomatology. METHODS: Seven inpatients with chronic schizophrenia presenting with treatment resistant negative symptoms were enrolled into exploratory treatment study with creatine monohydrate augmentation at a daily high-dose of 10 grams, administered for 6 months...
2015: Israel Journal of Psychiatry and related Sciences
Zhenguang Li, Pengfei Wang, Zhancai Yu, Yannan Cong, Hairong Sun, Jiangshan Zhang, Jinbiao Zhang, Chao Sun, Yong Zhang, Xiaohua Ju
BACKGROUND: To investigate the effect of creatine and coenzyme Q10 (CoQ10) combination therapy on mild cognitive impairment (MCI) in Parkinson's disease (PD; PD-MCI) and its influences on plasma phospholipid (PL) levels in PD-MCI. METHODS: The demographic data of 75 PD-MCI patients who enrolled in this collaborative PD study were collected. These patients were evaluated using the Unified Parkinson's Disease Rating Scale (UPDRS) III and the Montreal Cognitive Assessment (MoCA)...
2015: European Neurology
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