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https://www.readbyqxmd.com/read/29758980/metabolomics-for-the-effect-of-biotin-and-nicotinamide-on-transition-dairy-cows
#1
Xiaoshi Wei, Qingyan Yin, Huihui Zhao, Yangchun Cao, Chuanjiang Cai, Junhu Yao
The objective of this study was to evaluate alterations in serum metabolites of transition dairy cows affected by biotin (BIO) and nicotinamide (NAM) supplementation. Forty multiparous Holsteins were paired and assigned randomly within block to 1 of the following 4 treatments: control (T0), 30 mg/d BIO (TB), 45 g/d NAM (TN), and 30 mg/d BIO + 45 g/d NAM (TB+N). Supplemental BIO and NAM were drenched to cows from 14 days before the expected calving date. GC-TOF/MS was used to analyze serum samples collected from 8 cows in every groups at 14 days after calving...
May 14, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29749224/photoactivatable-rhodamine-spiroamides-and-diazoketones-decorated-with-universal-hydrophilizer-or-hydroxyl-groups
#2
Benoit Roubinet, Matthias Bischoff, Shamil Nizamov, Sergey Yan, Claudia Geisler, Stefan Stoldt, Gyuzel Y Mitronova, Vladimir N Belov, Mariano L Bossi, Stefan W Hell
Photoactivatable rhodamine spiroamides and spirocyclic diazoketones emerged recently as synthetic markers applicable in multicolor superresolution microscopy. However, their applicability in single molecule localization microscopy (SMLM) is often limited by aggregation, unspecific adhesion and low reactivity caused by insufficient solubility and precipitation from aqueous solutions. We report here two synthetic modifications increasing the polarity of compact polycyclic and hydrophobic labels decorated with a reactive group: attachment of 3-sulfo-L-alanyl - beta-alanine dipeptide (a "universal hydrophilizer") or allylic hydroxylation in photosensitive rhodamine diazoketones (and spiroamides)...
May 11, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29676523/characterization-of-low-abundance-species-in-the-active-pharmaceutical-ingredient-of-cigb-300-a-clinical-grade-anticancer-synthetic-peptide
#3
Hilda Garay, Luis Ariel Espinosa, Yasser Perera, Aniel Sánchez, David Diago, Silvio E Perea, Vladimir Besada, Osvaldo Reyes, Luis Javier González
CIGB-300 is a first-in-class synthetic peptide-based drug of 25 amino acids currently undergoing clinical trials in cancer patients. It contains an amidated disulfide cyclic undecapeptide fused to the TAT cell-penetrating peptide through a beta-alanine spacer. CIGB-300 inhibits the CK2-mediated phosphorylation leading to apoptosis of tumor cells in vitro, and in vivo in cancer patients. Despite the clinical development of CIGB-300, the characterization of peptide-related impurities present in the active pharmaceutical ingredient has not been reported earlier...
April 20, 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/29568236/alteration-of-metabolite-profiling-by-cold-atmospheric-plasma-treatment-in-human-myeloma-cells
#4
Dehui Xu, Yujing Xu, Ning Ning, Qingjie Cui, Zhijie Liu, Xiaohua Wang, Dingxin Liu, Hailan Chen, Michael G Kong
Background: Despite new progress of chemotherapy in multiple myeloma (MM) clinical treatment, MM is still a refractory disease and new technology is needed to improve the outcomes and prolong the survival. Cold atmospheric plasma is a rapidly developed technology in recent years, which has been widely applied in biomedicine. Although plasma could efficiently inactivate various tumor cells, the effects of plasma on tumor cell metabolism have not been studied yet. Methods: In this study, we investigated the metabolite profiling of He plasma treatment on myeloma tumor cells by gas-chromatography time-of-flight (GC-TOF) mass-spectrometry...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/29499574/metabolomic-analysis-of-two-rice-oryza-sativa-varieties-exposed-to-2-2-4-4-tetrabromodiphenyl-ether
#5
Jie Chen, Kelun Li, X Chris Le, Lizhong Zhu
Polybrominated diphenyl ethers (PBDEs) are toxic chemicals widely distributed in the environment, but few studies are available on their potential toxicity to rice at metabolic level. Therefore we exposed ten rice (Oryza sativa) varieties to 2,2',4,4'-tetrabromodiphenyl ether (BDE-47), a predominant congener of PBDEs, in hydroponic solutions with different concentrations. Two varieties that showed different biological effects to BDE-47, YY-9 and LJ-7, were screened as sensitive and tolerant varieties according to changes of morphological and physiological indicators...
June 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29465269/evidence-based-supplements-for-the-enhancement-of-athletic-performance
#6
REVIEW
Peter Peeling, Martyn J Binnie, Paul S R Goods, Marc Sim, Louise M Burke
A strong foundation in physical conditioning and sport-specific experience, in addition to a bespoke and periodized training and nutrition program, are essential for athlete development. Once these underpinning factors are accounted for, and the athlete reaches a training maturity and competition level where marginal gains determine success, a role may exist for the use of evidence-based performance supplements. However, it is important that any decisions surrounding performance supplements are made in consideration of robust information that suggests the use of a product is safe, legal, and effective...
March 1, 2018: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29394889/comparative-transcriptomic-analysis-of-resistant-and-susceptible-alfalfa-cultivars-medicago-sativa-l-after-thrips-infestation
#7
Xiongbing Tu, Zhongkuan Liu, Zehua Zhang
BACKGROUND: Plant breeding for resistance to agricultural pests is an essential element in the development of integrated crop management systems; however, the molecular and genetic mechanisms underlying resistance are poorly understood. In this pilot study, a transcriptomic analysis of a resistant (R) vs. a susceptible (S) variety of alfalfa, with (+T) or without (-T) thrips (= 4 treatments) was conducted, 'GN-1' (China) was defined as the resistant cultivar, and 'WL323' (America) was defined as the susceptible cultivar...
February 2, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29336621/beta-alanine-does-not-enhance-the-effects-of-resistance-training-in-older-adults
#8
Christopher H Bailey, Joseph F Signorile, Arlette C Perry, Kevin A Jacobs, Nicholas D Myers
To investigate the potential of beta-alanine to increase muscular endurance of elder individuals in specific resistance-training protocols, we randomly assigned 27 participants (60-82 years of age) to a 12-week double-blind intervention using 3.2 g/day beta-alanine or placebo with or without resistance training to determine the effects on anthropometrics, muscular performance, and activities of daily living (ADL). The endurance-based resistance-training program (ERT) was given three times per week and included two sets of 15-25 repetitions on 11 computerized pneumatic machines (alternating upper and lower body) at an intensity of 50% of maximum lifting weight (1RM)...
January 16, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29313412/physicochemical-screening-for-chemical-stabilizer-of-erythropoietin-to-prevent-its-aggregation
#9
Mehri Mortazavi, Mohammad Ali Shokrgozar, Soroush Sardari, Kayhan Azadmanesh, Reza Mahdian, Hooman Kaghazian, Seyed Nezamedin Hosseini, Elnaz Shams
Recombinant protein aggregation is a problematic issue and can provoke immunological response. The aim of this study was to analyze the stability of erythropoietin (EPO), as a therapeutic protein expressed in mammalian cells, in the presence of different chemicals and find a specific stabilizer for EPO. The effects of several chemicals, including mannitol, betaine, trehalose, taurine, linoleic acid, beta-cyclodextrin, copper sulfate, spermidine, maltose, maltodextrin, sucrose, dextran, beta-alanine, myo-inositol, and cysteine, on protein stabilization through the thermally induced aggregation of EPO were monitored...
February 7, 2018: Preparative Biochemistry & Biotechnology
https://www.readbyqxmd.com/read/29194995/the-dynamic-metabolomic-changes-throughout-mouse-epididymal-lumen-fluid-potentially-contribute-to-sperm-maturation
#10
S-G Hu, A-J Liang, G-X Yao, X-Q Li, M Zou, J-W Liu, Y Sun
Epididymal lumen fluids are directly responsible for sperm maturation. However, very little is known about the molecular details of small molecule metabolites in the epididymal lumen fluids until now. Here we identified and compared the metabolic profiles of mouse caput and cauda epididymal lumen fluids using GC-MS technique. Among 236 metabolites identified in caput and cauda epididymis, 36 were significantly enriched in caput epididymis while 18 were significantly enriched in cauda epididymis. Pathway analysis identified ascorbate and aldarate metabolism and beta-alanine metabolism as most relevant pathways in caput and cauda epididymis, respectively...
January 2018: Andrology
https://www.readbyqxmd.com/read/29186400/metabolites-associated-with-risk-of-developing-mobility-disability-in-the-health-aging-and-body-composition-study
#11
Rachel A Murphy, Steven Moore, Mary Playdon, Stephen Kritchevsky, Anne B Newman, Suzanne Satterfield, Hilsa Ayonayon, Clary Clish, Robert Gerszten, Tamara B Harris
Background: Metabolic pathways that give rise to functional decline and mobility disability in older adults are incompletely understood. Methods: To identify metabolic perturbations that may impact functional decline, non-targeted metabolomics was used to measure 350 metabolites in baseline plasma from 313 black men in the Health ABC Study (median age 74 years). Usual gait speed was measured over 20 meters. Cross-sectional relationships between gait speed and metabolites were explored with partial correlations adjusted for age, study site and smoking status...
November 25, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29159570/multi-timescale-analysis-of-a-metabolic-network-in-synthetic-biology-a-kinetic-model-for-3-hydroxypropionic-acid-production-via-beta-alanine
#12
Mohit P Dalwadi, John R King, Nigel P Minton
A biosustainable production route for 3-hydroxypropionic acid (3HP), an important platform chemical, would allow 3HP to be produced without using fossil fuels. We are interested in investigating a potential biochemical route to 3HP from pyruvate through [Formula: see text]-alanine and, in this paper, we develop and solve a mathematical model for the reaction kinetics of the metabolites involved in this pathway. We consider two limiting cases, one where the levels of pyruvate are never replenished, the other where the levels of pyruvate are continuously replenished and thus kept constant...
November 20, 2017: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/29131611/synthesis-and-in-vitro-evaluation-of-monodisperse-amino-functional-polyester-dendrimers-with-rapid-degradability-and-antibacterial-properties
#13
Patrik Stenström, Erik Hjorth, Yuning Zhang, Oliver C J Andrén, Simon Guette-Marquet, Marianne Schultzberg, Michael Malkoch
Amine functional polymers, especially cationically charged, are interesting biomacromolecules for several reasons, including easy cell membrane entrance, their ability to escape endosomes through the proton sponge effect, spontaneous complexation and delivery of drugs and siRNA, and simple functionalization in aqueous solutions. Dendrimers, a subclass of precision polymers, are monodisperse and exhibit a large and exact number of peripheral end groups in relation to their size and have shown promise in drug delivery, biomedical imaging and as antiviral agents...
December 11, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29077023/design-of-tail-clamp-peptide-nucleic-acid-tethered-with-azobenzene-linker-for-sequence-specific-detection-of-homopurine-dna
#14
Shinjiro Sawada, Toshifumi Takao, Nobuo Kato, Kunihiro Kaihatsu
DNA carries genetic information in its sequence of bases. Synthetic oligonucleotides that can sequence-specifically recognize a target gene sequence are a useful tool for regulating gene expression or detecting target genes. Among the many synthetic oligonucleotides, tail-clamp peptide nucleic acid (TC-PNA) offers advantages since it has two homopyrimidine PNA strands connected via a flexible ethylene glycol-type linker that can recognize complementary homopurine sequences via Watson-Crick and Hoogsteen base pairings and form thermally-stable PNA/PNA/DNA triplex structures...
October 27, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29018486/serum-and-liver-tissue-metabonomic-study-on-fatty-liver-in-rats-induced-by-high-fat-diet-and-intervention-effects-of-traditional-chinese-medicine-qushi-huayu-decoction
#15
Xiao-Jun Gou, Qin Feng, Lin-Lin Fan, Jian Zhu, Yi-Yang Hu
Qushi Huayu Decoction (QSHY), clinically derived, consists of five crude drugs, commonly used in treating fatty liver in a clinical setting. However, little is known about its metabolomics study. Herein, the serum and liver tissue metabolomics approach, based on gas chromatography coupled to spectrometry (GC/MS), was employed to evaluate the efficacy and the mechanism underlying QSHY in a rat model of high-fat diet-induced fatty liver. With pattern recognition analysis of serum and liver tissue metabolite profile, a clear separation of model group and control group was acquired for serum and liver tissue samples, respectively...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28959247/microbiome-metabolome-responses-to-a-high-grain-diet-associated-with-the-hind-gut-health-of-goats
#16
Shiyu Tao, Ping Tian, Yanwen Luo, Jing Tian, Canfeng Hua, Yali Geng, Rihua Cong, Yingdong Ni, Ruqian Zhao
Studies on the effect of a high-concentrate (HC) diet on the hindgut microbiota and metabolome of ruminants are rarely reported. We used 454 pyrosequencing of 16S rDNA genes and gas chromatography-mass spectrometry to evaluate the effects of long-term feeding (HL) or short-term (HS) feeding of an HC diet on changes in bacterial microbiota and their metabolites in the hindgut, with Guanzhong goat as a ruminant model. Results indicated that an HC diet decreased bacterial diversity and induced metabolic disorder in the hindgut...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28937628/integrative-pathway-analysis-of-genes-and-metabolites-reveals-metabolism-abnormal-subpathway-regions-and-modules-in-esophageal-squamous-cell-carcinoma
#17
Chunquan Li, Qiuyu Wang, Jiquan Ma, Shengshu Shi, Xin Chen, Haixiu Yang, Junwei Han
Aberrant metabolism is one of the main driving forces in the initiation and development of ESCC. Both genes and metabolites play important roles in metabolic pathways. Integrative pathway analysis of both genes and metabolites will thus help to interpret the underlying biological phenomena. Here, we performed integrative pathway analysis of gene and metabolite profiles by analyzing six gene expression profiles and seven metabolite profiles of ESCC. Multiple known and novel subpathways associated with ESCC, such as 'beta-Alanine metabolism', were identified via the cooperative use of differential genes, differential metabolites, and their positional importance information in pathways...
September 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28828081/effects-of-plyometric-training-and-beta-alanine-supplementation-on-maximal-intensity-exercise-and-endurance-in-female-soccer-players
#18
Fabián Rosas, Rodrigo Ramírez-Campillo, Cristian Martínez, Alexis Caniuqueo, Rodrigo Cañas-Jamet, Emma McCrudden, Cesar Meylan, Jason Moran, Fábio Y Nakamura, Lucas A Pereira, Irineu Loturco, Daniela Diaz, Mikel Izquierdo
Plyometric training and beta-alanine supplementation are common among soccer players, although its combined use had never been tested. Therefore, a randomized, double-blind, placebo-controlled trial was conducted to compare the effects of a plyometric training program, with or without beta-alanine supplementation, on maximal-intensity and endurance performance in female soccer players during an in-season training period. Athletes (23.7 ± 2.4 years) were assigned to either a plyometric training group receiving a placebo (PLACEBO, n = 8), a plyometric training group receiving beta-alanine supplementation (BA, n = 8), or a control group receiving placebo without following a plyometric training program (CONTROL, n = 9)...
September 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28818411/long-term-supplementation-with-egcg-and-beta-alanine-decreases-mortality-but-does-not-affect-cognitive-or-muscle-function-in-aged-mice
#19
Brandt D Pence, Tushar K Bhattacharya, Pul Park, Jennifer L Rytych, Jacob M Allen, Yi Sun, Robert H McCusker, Keith W Kelley, Rodney W Johnson, Justin S Rhodes, Jeffrey A Woods
We have previously shown that 6weeks of a diet containing epigallocatechin gallate (EGCG) and beta-alanine (B-ALA) was not effective in improving either cognitive or muscle function in aged (18month) mice (Gibbons et al. Behav Brain Res 2014). However, diet reduced oxidative stress in the brain, and previous studies using longer-term interventions have documented beneficial effects in cognitive, but not muscle, function. Therefore, we investigated the effect of 6months of feeding on measures of cognitive and muscle function in mice...
November 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28806173/the-%C3%AE-alanine-transporter-balat-is-required-for-visual-neurotransmission-in-drosophila
#20
Yongchao Han, Liangyao Xiong, Ying Xu, Tian Tian, Tao Wang
The recycling of neurotransmitters is essential for sustained synaptic transmission. In Drosophila, histamine recycling is required for visual synaptic transmission. Synaptic histamine is rapidly taken up by laminar glia, and is converted to carcinine. After delivered back to photoreceptors, carcinine is hydrolyzed to release histamine and β-alanine. This histamine is repackaged into synaptic vesicles, but it is unclear how the β-alanine is returned to the laminar glial cells. Here, we identified a new β-alanine transporter, which we named BalaT (Beta-alanine Transporter)...
August 14, 2017: ELife
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