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Dante Rojas, Gaud Dervilly-Pinel, Nora Cesbron, Mylène Penot, Alexandre Sydor, Stéphanie Prévost, Bruno Le Bizec
Besides their development for therapeutic purposes, non-steroidal selective androgen receptor modulators (non-steroidal SARMs) are also known to impact growth associated pathways as ligands of androgenic receptors (AR). They present thus a potential for abuse in sports and food producing animals as an interesting alternative to anabolic androgenic steroids (AAS). These compounds are easily available and could therefore be (mis)used in livestock production as growth promoters. To prevent such practices, dedicated analytical strategies have to be developed for specific and sensitive detection of these compounds in biological matrices...
October 11, 2016: Drug Testing and Analysis
Christian Görgens, Sven Guddat, Andreas Thomas, Philipp Wachsmuth, Anne-Katrin Orlovius, Gerd Sigmund, Mario Thevis, Wilhelm Schänzer
So far, in sports drug testing compounds of different classes are processed and measured using different screening procedures. The constantly increasing number of samples in doping analysis, as well as the large number of substances with doping related, pharmacological effects require the development of even more powerful assays than those already employed in sports drug testing, indispensably with reduced sample preparation procedures. The analysis of native urine samples after direct injection provides a promising analytical approach, which thereby possesses a broad applicability to many different compounds and their metabolites, without a time-consuming sample preparation...
November 30, 2016: Journal of Pharmaceutical and Biomedical Analysis
Suriyan Ponnusamy, Ryan D Sullivan, Thirumagal Thiyagarajan, Heather Tillmann, Robert H Getzenberg, Ramesh Narayanan
OBJECTIVES: To evaluate two selective androgen receptor modulators (SARMs) (GTx-024 and GTx-027) in a post-menopausal animal model in order to determine their effect on pelvic floor muscles. Stress urinary incontinence (SUI), a prevalent condition, is represented by an involuntary leakage of urine that results, at least in part, from weakened or damaged pelvic floor muscles and is triggered by physical stress. Current treatment options are limited with no oral therapies available. The pelvic floor is rich in androgen receptor and molecules with anabolic activity including (SARMs) may serve as therapeutic options for individuals with SUI...
September 28, 2016: Journal of Cellular Biochemistry
Yu Gong, Lin Zou, Dongzhi Cen, Wei Chao, Dunjin Chen
Objective Immune dysfunction, including prominent apoptosis of immune cells and decreased functioning of the remaining immune cells, plays a central role in the pathogenesis of sepsis. Sterile α and HEAT/armadillo motif-containing protein (SARM) is implicated in the regulation of immune cell apoptosis. This study aimed to elucidate SARM contributes to sepsis-induced immune cell death and immunosuppression. Methods A mouse model of polymicrobial sepsis was generated by cecum ligation and puncture (CLP). SARM gene and protein expression, caspase 3 cleavage and intracellular ATP production were measured in the mouse spleens...
September 2, 2016: Inflammation
Christopher Wu, Jason R Kovac
There has recently been renewed interest in novel clinical applications of the anabolic-androgenic steroid (AAS) testosterone and its synthetic derivatives, particularly given with the rising popularity of testosterone supplementation therapy (TST) for the treatment of male hypogonadism. In this manuscript, we provide a brief review of the history of AAS and discuss clinical applications of two of the more well-known AAS: nandrolone and oxandrolone. Both agents exhibit favorable myotrophic/androgenic ratios and have been investigated for effectiveness in numerous disease states...
October 2016: Current Urology Reports
Mohammad Zandi, Amirfarhang Miresmaeili, Ali Heidari, Arash Lamei
PURPOSE: To evaluate and compare the short-term skeletal and dental changes following surgically assisted rapid maxillary expansion (SARME) with or without pterygomaxillary disjunction (PTMD) using cone beam computed tomography (CBCT). MATERIAL AND METHODS: In present study, a total of 15 consecutive patients with transverse maxillary deficiency underwent SARME without PTMD. This prospective group was compared to one arm of a randomized controlled clinical trial the authors of present study published in 2014, in which 15 patients underwent SARME with PTMD...
September 2016: Journal of Cranio-maxillo-facial Surgery
Vishnu Lal Sharma, Sonal Gupta, Gopal Gupta
Proliferation of the smooth muscle and epithelial cells within the prostatic transition zone in older men leads to benign prostatic hyperplasia (BPH) which is hallmarked by the troublesome lower urinary tract symptoms. The affair responsible for the initiation and promotion of disease is still unresolved. Alpha blockers and 5α-reductase inhibitors are used as management options for relief of the dynamic and static components respectively. Combination therapy including both the alpha blocker and 5α-reductase inhibitors is emerging as inclusive parcel for treatment...
June 30, 2016: Mini Reviews in Medicinal Chemistry
Felix Kunz, Christian Linz, Gregor Baunach, Hartmut Böhm, Philipp Meyer-Marcotty
OBJECTIVES: The purpose of this work was to compare the patterns of expansion resulting from a tooth-borne hyrax appliance and a bone-borne transpalatal distractor in patients treated by surgically assisted rapid maxillary expansion (SARME). METHODS: A total of 28 patients with transverse maxillary hypoplasia were treated by SARME, using a hyrax appliance in 12 and a transpalatal distractor in 16 cases. Before and after palatal expansion, an impression of each maxilla was taken...
September 2016: Journal of Orofacial Orthopedics, Fortschritte der Kieferorthopädie
Andreas Lagojda, Dirk Kuehne, Oliver Krug, Andreas Thomas, Tina Wigger, Uwe Karst, Wilhelm Schänzer, Mario Thevis
Research into developing anabolic agents for various therapeutic purposes has been pursued for decades. As the clinical utility of anabolic-androgenic steroids has been found to be limited because of their lack of tissue selectivity and associated off-target effects, alternative drug entities have been designed and are commonly referred to as selective androgen receptor modulators (SARMs). While most of these SARMs are of nonsteroidal structure, the drug candidate MK-0773 comprises a 4-aza-steroidal nucleus...
2016: European Journal of Mass Spectrometry
Kenta Watanabe, Michiko Hirata, Tsukasa Tominari, Chiho Matsumoto, Yasuyuki Endo, Gillian Murphy, Hideaki Nagase, Masaki Inada, Chisato Miyaura
Carboranes are a class of carbon-containing polyhedral boron cluster compounds with globular geometry and hydrophobic surface that interact with hormone receptors such as estrogen receptor (ER) and androgen receptor (AR). We have synthesized BA321, a novel carborane compound, which binds to AR. We found here that it also binds to ERs, ERα and ERβ. In orchidectomized (ORX) mice, femoral bone mass was markedly reduced due to androgen deficiency and BA321 restored bone loss in the male, whilst the decreased weight of seminal vesicle in ORX mice was not recovered by administration of BA321...
September 9, 2016: Biochemical and Biophysical Research Communications
Toshihiko Yanase
In recent years, the drugs, which show anabolic, effect on bone and muscle without stimulating prostate has been developed. They show tissue-specific selective androgen actions and called selective androgen receptor modulators(SARMs). The development of drug targeting bone and muscle in male is very promising as a treatment tool for osteoporosis and sarcopenia in the near future. The clinical study is under going especially in the field of cachexia associated with cancer, but unfortunately there is no drug in the current market at present...
July 2016: Clinical Calcium
O Tšuiko, M Nõukas, O Žilina, K Hensen, J S Tapanainen, R Mägi, M Kals, P A Kivistik, K Haller-Kikkatalo, A Salumets, A Kurg
STUDY QUESTION: Can spontaneous premature ovarian failure (POF) patients derived from population-based biobanks reveal the association between copy number variations (CNVs) and POF? SUMMARY ANSWER: CNVs can hamper the functional capacity of ovaries by disrupting key genes and pathways essential for proper ovarian function. WHAT IS KNOWN ALREADY: POF is defined as the cessation of ovarian function before the age of 40 years. POF is a major reason for female infertility, although its cause remains largely unknown...
August 2016: Human Reproduction
Jeffrey Crawford, Carla M M Prado, Mary Ann Johnston, Richard J Gralla, Ryan P Taylor, Michael L Hancock, James T Dalton
Muscle wasting in cancer is a common and often occult condition that can occur prior to overt signs of weight loss and before a clinical diagnosis of cachexia can be made. Muscle wasting in cancer is an important and independent predictor of progressive functional impairment, decreased quality of life, and increased mortality. Although several therapeutic agents are currently in development for the treatment of muscle wasting or cachexia in cancer, the majority of these agents do not directly inhibit muscle loss...
June 2016: Current Oncology Reports
A S Dubenskiy, I F Seregina, Z K Blinnikova, M P Tsyurupa, L A Pavlova, V A Davankov, M A Bolshov
The reversible sorption preconcentration of noble metals (NMs) prior to their determination by inductively coupled plasma-mass spectrometry (ICP-MS) was investigated. Six new hypercrosslinked polystyrene sorbents were tested. The dependence of the degree of NMs sorption on the average degree of polymer network crosslinking and pore diameters was investigated. It was found that sorbents HP-100/6, HP-300/6 and HP-500/6 have low efficiency of NMs chlorocomplexes extraction. Among Stirosorb sorbents (Stirosorb-2, Stirosorb-514 and Stirosorb-584) the highest efficiency of the extraction of NMs' chlorocomplexes has Stirosorb-514...
June 1, 2016: Talanta
Sarmed S Sami, Krish Ragunath, Emilie A Wilkes, Martin James, Rodrigo Mansilla-Vivar, Jacobo Ortiz-Fernández-Sordo', Jonathan White, Amardeep Khanna, Marina Coletta, Sunil Samuel, Guruprasad P Aithal, Indra Neil Guha
BACKGROUND AND AIMS: Screening for oesophageal varices (OV) using conventional oesophagogastroduodenoscopy (C-OGD) is invasive and requires costly monitoring, recovery, and decontamination facilities. We aimed to evaluate the technical feasibility, acceptability and accuracy of a novel, portable, and disposable office-based transnasal endoscope (EG Scan(™) ) compared to C-OGD as the reference standard. METHODS: This was a prospective cohort study. Consecutive adult patients with liver cirrhosis were invited to participate...
April 28, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
Michael J Chisamore, Michael A Gentile, Gregory Michael Dillon, Matthew Baran, Carlo Gambone, Sean Riley, Azriel Schmidt, Osvaldo Flores, Hilary Wilkinson, Stephen E Alves
The androgen receptor (AR) is a member of the nuclear hormone receptor super family of transcription factors. Androgens play an essential role in the development, growth, and maintenance of male sex organs, as well as the musculoskeletal and central nervous systems. Yet with advancing age, androgens can drive the onset of prostate cancer, the second leading cause of cancer death in males within the United States. Androgen deprivation therapy (ADT) by pharmacologic and/or surgical castration induces apoptosis of prostate cells and subsequent shrinkage of the prostate and prostate tumors...
October 2016: Journal of Steroid Biochemistry and Molecular Biology
Douglas A Gibson, Ioannis Simitsidellis, Philippa T K Saunders
During the establishment of pregnancy, the ovarian-derived hormones progesterone and oestradiol regulate remodelling of the endometrium to promote an environment that is able to support and maintain a successful pregnancy. Decidualisation is characterised by differentiation of endometrial stromal cells that secrete growth factors and cytokines that regulate vascular remodelling and immune cell influx. This differentiation process is critical for reproduction, and inadequate decidualisation is implicated in the aetiology of pregnancy disorders such as foetal growth restriction and preeclampsia...
July 2016: Journal of Molecular Endocrinology
Luigi Laino, Giuseppe Troiano, Mario Dioguardi, Letizia Perillo, Gregorio Laino, Lorenzo Lo Muzio, Marco Cicciù
The aim of this study was to evaluate whether surgically assisted rapid maxillary expansion (SARME) could be performed under local anaesthesia and to understand the patient discomfort associated with this protocol. Patient discomfort was compared during and after 2 different types of oral surgical treatments in the same patients. Odontectomies for impacted lower third molar (control) were compared with SARME procedures (test) that were also performed under local anaesthesia. A visual analogic scale was used for each patient to quantify his or her discomfort before and after surgery...
May 2016: Journal of Craniofacial Surgery
L F M Sant'Ana, C R M Pinzan-Vercelino, J A Gurgel, P S P Carvalho
The purpose of this study was to compare the efficacy and the patients' subjective symptomatology between surgically assisted rapid maxillary expansion (SARME) with midpalatal split and SARME without midpalatal split. The sample consisted of 24 consecutive adult patients requiring treatment with SARME, who were divided into two groups. Group 1 patients (n=14) underwent SARME with midpalatal split, and group 2 patients (n=10) underwent SARME without midpalatal separation. The efficacy of the technique was assessed in relation to the presence of a diastema between the upper incisors and radiographic evidence of separation of the maxillary bones in the midpalatal suture...
August 2016: International Journal of Oral and Maxillofacial Surgery
Lucia Giannini, Cinzia Maspero, Guido Galbiati, Mattia Feresini, Giampietro Farronato
BACKGROUND: The aim of this retrospective study was to evaluate and compare cephalometrically the skeletal and dental effects of maxillary expansion by the rapid maxillary expander compared to a surgical assisted rapid maxillary expansion. METHODS: The records which included 102 patients (50 female, 52 male) with maxillary bilateral cross bite caused by narrowness of the apical base are collected and divided into two treatment groups: the first group (63 patients, 36 male and 27 female) included patients who had been treated with an orthopedic rapid maxillary expander...
April 2016: Minerva Stomatologica
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