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Respiratory Compensation Point

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https://www.readbyqxmd.com/read/28888990/chemicals-or-mutations-that-target-mitochondrial-translation-can-rescue-the-respiratory-deficiency-of-yeast-bcs1-mutants
#1
C Panozzo, A Laleve, D Tribouillard-Tanvier, J Ostojić, C Sellem, G Friocourt, A Bourand-Plantefol, A Burg, A Delahodde, M Blondel, G Dujardin
Bcs1p is a chaperone that is required for the incorporation of the Rieske subunit within complex III of the mitochondrial respiratory chain. Mutations in the human gene BCS1L (BCS1-like) are the most frequent nuclear mutations resulting in complex III-related pathologies. In yeast, the mimicking of some pathogenic mutations causes a respiratory deficiency. We have screened chemical libraries and found that two antibiotics, pentamidine and clarithromycin, can compensate two bcs1 point mutations in yeast, one of which is the equivalent of a mutation found in a human patient...
September 6, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28878694/physiological-responses-to-firefighting-in-extreme-temperatures-do-not-compare-to-firefighting-in-temperate-conditions
#2
Stephanie Windisch, Wolfgang Seiberl, Daniel Hahn, Ansgar Schwirtz
Purpose: The aim of this study was to examine physiological responses to two different simulated firefighting exercises: a firefighting exercise with flashovers, smoke, poor visibility and extreme temperatures (300°) in a burning container and a standard firefighting exercise in temperate conditions. Furthermore, a second purpose of the study was to find out if the contribution of strength and endurance capacities to firefighting performance changes when the demands of the firefighting exercise change. Methods: Sixteen professional firefighters performed a maximum treadmill test, strength testing, a standard simulated firefighting exercise (SFE) without heat and flashovers and a firefighting exercise with a simulation of the flashover phenomenon in a burning container (FOT)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28838335/comparative-determination-of-ventilatory-efficiency-from-constant-load-and-incremental-exercise-testing
#3
S Algul, F A Ugur, A Ayar, O Ozcelik
The analysis of the relationships between minute ventilation (VE) to CO2 output (VCO2), referred to as ventilatory efficiency, in response to incremental exercise testing, is considered a useful index for assessing the presence and severity of cardiopulmonary and metabolic diseases. The effects of constant load exercise testing performed at work intensity associated with anaerobic threshold (AT) and respiratory compensation points (RCP), on the accurate measurements of ventilatory efficiency are not well known...
August 15, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28713464/a-rapidly-incremented-tethered-swimming-test-for-defining-domain-specific-training-zones
#4
Dalton M Pessôa Filho, Leandro O C Siqueira, Astor R Simionato, Mário A C Espada, Daniel S Pestana, Fred J DiMenna
The purpose of this study was to investigate whether a tethered-swimming incremental test comprising small increases in resistive force applied every 60 seconds could delineate the isocapnic region during rapidly-incremented exercise. Sixteen competitive swimmers (male, n = 11; female, n = 5) performed: (a) a test to determine highest force during 30 seconds of all-out tethered swimming (Favg) and the ΔF, which represented the difference between Favg and the force required to maintain body alignment (Fbase), and (b) an incremental test beginning with 60 seconds of tethered swimming against a load that exceeded Fbase by 30% of ΔF followed by increments of 5% of ΔF every 60 seconds...
June 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28692969/an-mr-based-model-for-cardio-respiratory-motion-compensation-of-overlays-in-x-ray-fluoroscopy
#5
Peter Fischer, Anthony Faranesh, Thomas Pohl, Andreas Maier, Toby Rogers, Kanishka Ratnayaka, Robert Lederman, Joachim Hornegger
In X-ray fluoroscopy, static overlays are used to visualize soft tissue. We propose a system for cardiac and respiratory motion compensation of these overlays. It consists of a 3-D motion model created from real-time MR imaging. Multiple sagittal slices are acquired and retrospectively stacked to consistent 3-D volumes. Slice stacking considers cardiac information derived from the ECG and respiratory information extracted from the images. Additionally, temporal smoothness of the stacking is enhanced. Motion is estimated from the MR volumes using deformable 3-D/3-D registration...
July 4, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28674603/mathematical-modeling-and-expression-of-heart-rate-deflection-point-using-heart-rate-and-oxygen-consumption
#6
Kayla M Baker, David H Fukuda, David D Church, Michael B LA Monica, Kyle S Beyer, Jay R Hoffman, Jeffrey R Stout
Heart rate deflection point (HRDP) can be determined through different mathematical-modeling procedures, such as bi-segmental linear regression (2SEG) or maximal distance model (Dmax). The purpose was to compare heart rate (HR) and oxygen consumption (VO2) at HRDP when using 2SEG and Dmax, and to examine their relationships with respiratory compensation point (RCP) and running performance. Nineteen participants completed a graded exercise test (GXT), to determine HRDP and RCP, and a 5km treadmill time trial (5Ktime)...
2017: International Journal of Exercise Science
https://www.readbyqxmd.com/read/28524033/-procedural-analysis-of-acid-base-balance-disorder-case-serials-in-4-patents
#7
Chunyuan Ma, Guijie Wang
OBJECTIVE: To establish the standardization process of acid-base balance analysis, analyze cases of acid-base balance disorder with the aid of acid-base balance coordinate graph. METHODS: The acid-base balance theory were reviewed systematically on recent research progress, and the important concepts, definitions, formulas, parameters, regularity and inference in the analysis of acid-base balance were studied. The analysis of acid-base balance disordered processes and steps were figured...
May 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28475960/health-risk-assessment-of-exposure-to-the-middle-eastern-dust-storms-in-the-iranian-megacity-of-kermanshah
#8
G Goudarzi, S M Daryanoosh, H Godini, P K Hopke, P Sicard, A De Marco, H D Rad, A Harbizadeh, F Jahedi, M J Mohammadi, J Savari, S Sadeghi, Z Kaabi, Y Omidi Khaniabadi
OBJECTIVE: This study assessed the effects of particulate matter (PM), equal or less than 10 μm in aerodynamic diameter (PM10), from the Middle-Eastern Dust events on public health in the megacity of Kermanshah (Iran). STUDY DESIGN: This study used epidemiological modeling and monitored ambient air quality data to estimate the potential PM10 impacts on public health. METHODS: The AirQ2.2.3 model was used to calculate mortality and morbidity attributed to PM10 as representative of dust events...
July 2017: Public Health
https://www.readbyqxmd.com/read/28466818/evaluation-of-relationship-between-aerobic-fitness-level-and-range-of-isocapnic-buffering-periods-during-incremental-exercise-test
#9
S Algul, O Ozcelik, B Yilmaz
The purpose of this study is to examine the relationship between the amount of O2 uptake (VO2) in the range of isocapnic buffering (ICB) periods and aerobic fitness levels of subjects with different exercise tolerance levels. A total of 50 young male subjects (20.8±0.4 years) performed an incremental exercise test using a cycle ergometer to determinetheir anaerobic threshold (AT), respiratory compensation point (RCP) and maximal exercise capacity (Wmax). The ICB period is defined as the region between AT and RCP...
March 31, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28414006/unit-cost-of-common-illness-management-a-comparison-between-a-primary-care-unit-and-a-community-pharmacy-in-thailand
#10
Kritsanee Saramunee, Chanuttha Ploylearmsang, Surasak Chaiyasong, Wiraphol Phimarn, Phayom Sookaneknun
Aim This study was to perform unit cost analysis of managing common illnesses comparing between a primary care unit (PCU) and a community pharmacy. BACKGROUND: PCU is a key point of access for primary care in Thailand. Although a community pharmacy is an ideal setting, it has not been successfully incorporated in Thailand's health service. Common illnesses are encountered everyday by community pharmacists, an appropriate compensation for this service has not been established. METHODS: A primary care service of one educational institution was a study site...
April 17, 2017: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/28389601/anterior-cerebral-blood-velocity-and-end-tidal-co2-responses-to-exercise-differ-in-children-and-adults
#11
COMPARATIVE STUDY
Lindsay A Ellis, Philip N Ainslie, Victoria A Armstrong, Laura E Morris, Ryan G Simair, Nathan R Sletten, Christine M Tallon, Ali M McManus
Little is known about the response of the cerebrovasculature to acute exercise in children and how these responses might differ with adults. Therefore, we compared changes in middle cerebral artery blood velocity (MCAVmean), end-tidal Pco2 ([Formula: see text]), blood pressure, and minute ventilation (V̇e) in response to incremental exercise between children and adults. Thirteen children [age: 9 ± 1 (SD) yr] and thirteen sex-matched adults (age: 25 ± 4 yr) completed a maximal exercise test, during which MCAVmean, [Formula: see text], and V̇e were measured continuously...
June 1, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28370024/prefrontal-oxygenation-and-the-acoustic-startle-eyeblink-response-during-exercise-a-test-of-the-dual-mode-model
#12
Gavin D Tempest, Gaynor Parfitt
The interplay between the prefrontal cortex and amygdala is proposed to explain the regulation of affective responses (pleasure/displeasure) during exercise as outlined in the dual-mode model. However, due to methodological limitations the dual-mode model has not been fully tested. In this study, prefrontal oxygenation (using near-infrared spectroscopy) and amygdala activity (reflected by eyeblink amplitude using acoustic startle methodology) were recorded during exercise standardized to metabolic processes: 80% of ventilatory threshold (below VT), at the VT, and at the respiratory compensation point (RCP)...
March 30, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28338378/validation-of-a-maximal-incremental-skating-test-performed-on-a-slide-board-comparison-with-treadmill-skating
#13
Tatiane Piucco, Fernando Diefenthaeler, Rogério Soares, Juan M Murias, Guillaume Y Millet
PURPOSE: the aim of this study was to investigate the criterion validity of a maximal incremental skating test performed on a slide board (SB). METHODS: Twelve sub-elite speed skaters performed a maximal skating test on a treadmill and on a SB. Gas exchange threshold (GET), respiratory compensation point (RCP) and maximal variables were determined. RESULTS: oxygen uptake (V̇O2) (31.0 ± 3.2 and 31.4 ± 4.1 mL∙min(-1)∙kg(-1)), percentage of maximal oxygen uptake (V̇O2max) (66...
March 24, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28300367/4d-vmat-planning-and-verification-technique-for-dynamic-tracking-using-a-direct-aperture-deformation-dad-method
#14
Yongqian Zhang, Yong Yang, Weihua Fu, Xiang Li, Tianfang Li, Dwight E Heron, M Saiful Huq
We developed a four-dimensional volumetric modulated arc therapy (4D VMAT) planning technique for moving targets using a direct aperture deformation (DAD) method and investigated its feasibility for clinical use. A 3D VMAT plan was generated on a reference phase of a 4D CT dataset. The plan was composed of a set of control points including the beam angle, MLC apertures and weights. To generate the 4D VMAT plan, these control points were assigned to the closest respiratory phases using the temporal information of the gantry angle and respiratory curve...
March 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28271801/pediatric-aerobic-fitness-and-trainability
#15
Neil Armstrong
Three papers which between them raise controversial issues, apply laboratory measures to sport performance, and expose gaps in knowledge were selected for commentary. The first paper (Sports Med. 2016;46:1451-1460) reviews the literature on peak V̇O2 in relation to body size and recommends that peak V̇O2 in youth is best expressed via allometric scaling of lean body mass. The second paper (Pediatr Exerc Sci. 2016;28:456-465) reports that maturity status has no effect on peak V̇O2, respiratory compensation point, or ventilatory threshold in youth soccer players once data have been allometrically normalized by lower limb muscle volume...
February 2017: Pediatric Exercise Science
https://www.readbyqxmd.com/read/28258401/respiratory-motion-compensation-for-the-robot-guided-laser-osteotome
#16
Alina Giger, Christoph Jud, Philippe C Cattin
PURPOSE: The use of a robot-guided laser osteotome for median sternotomy is impeded by prohibiting cutting inaccuracies due to respiration-induced motions of the thorax. With this paper, we advance today's methodologies in sternotomy procedures by introducing the concept of novel 3D functional cuts and a respiratory motion compensation algorithm for the computer-assisted and robot-guided laser osteotome, CARLO(®). METHODS: We present a trajectory planning algorithm for performing 3D functional cuts at a constant cutting velocity...
March 3, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28254143/the-near-infrared-spectroscopy-derived-deoxygenated-haemoglobin-breaking-point-is-a-repeatable-measure-that-demarcates-exercise-intensity-domains
#17
Danilo Iannetta, Ahmad Qahtani, Felipe Mattioni Maturana, Juan Manuel Murias
OBJECTIVES: A breaking-point in the near-infrared spectroscopy (NIRS)-derived deoxygenated haemoglobin ([HHb]) profile towards the end of a ramp incremental (RI) cycling test has been associated to the respiratory compensation point (RCP). Despite the physiological value of this measure, its repeatability remains unknown. The aim was to examine the repeatability of the [HHb] breaking-point ([HHb]BP) and its association to RCP during a RI cycling test. DESIGN: A repeated measures design was performed on 11 males (30...
February 18, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28250511/implementation-research-on-community-health-workers-provision-of-maternal-and-child-health-services-in-rural-liberia
#18
Peter W Luckow, Avi Kenny, Emily White, Madeleine Ballard, Lorenzo Dorr, Kirby Erlandson, Benjamin Grant, Alice Johnson, Breanna Lorenzen, Subarna Mukherjee, E John Ly, Abigail McDaniel, Netus Nowine, Vidiya Sathananthan, Gerald A Sechler, John D Kraemer, Mark J Siedner, Rajesh Panjabi
OBJECTIVE: To assess changes in the use of essential maternal and child health services in Konobo, Liberia, after implementation of an enhanced community health worker (CHW) programme. METHODS: The Liberian Ministry of Health partnered with Last Mile Health, a nongovernmental organization, to implement a pilot CHW programme with enhanced recruitment, training, supervision and compensation. To assess changes in maternal and child health-care use, we conducted repeated cross-sectional cluster surveys before (2012) and after (2015) programme implementation...
February 1, 2017: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/28211607/physiological-motion-modeling-for-organ-mounted-robots
#19
Nathan A Wood, David Schwartzman, Marco A Zenati, Cameron N Riviere
BACKGROUND: Organ-mounted robots passively compensate heartbeat and respiratory motion. In model-guided procedures, this motion can be a significant source of information that can be used to aid in localization or to add dynamic information to static preoperative maps. METHODS: Models for estimating periodic motion are proposed for both position and orientation. These models are then tested on animal data and optimal orders are identified. Finally, methods for online identification are demonstrated...
February 17, 2017: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/28166117/the-respiratory-compensation-point-is-not-a-valid-surrogate-for-critical-power
#20
Jeffrey A Leo, Surendran Sabapathy, Michael J Simmonds, Troy J Cross
PURPOSE: It is unclear whether the respiratory compensation point (RCP) may be used as a valid surrogate for critical power (CP). Accordingly, we sought to determine the measurement agreement between the CP and the RCP obtained during incremental cycling of varying ramp slopes. METHODS: Eleven recreationally active men completed three separate ramp-incremental cycling protocols, where the work rate increment was slow (SR, 15 W·min), medium (MR, 30 W·min), or fast (FR, 45 W·min)...
July 2017: Medicine and Science in Sports and Exercise
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