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https://www.readbyqxmd.com/read/28318060/integrating-postural-and-vestibular-dimensions-to-depict-impairment-in-moderate-to-severe-obstructive-sleep-apnea-syndrome-patients
#1
Alessandro Micarelli, Claudio Liguori, Andrea Viziano, Francesca Izzi, Fabio Placidi, Marco Alessandrini
Vestibular dysfunction was linked to moderate-to-severe obstructive sleep apnea syndrome (OSAS) patients in literature. However, due to a lack of knowledge among valid and recent implementations conceived to study postural control on static posturography (SP) and vestibulo-ocular reflex (VOR) gain under physiological conditions (video Head Impulse Test; vHIT), the aim of this work was to integrate (i) VOR changes via vHIT implementation, (ii) postural arrangement by studying both classical parameters and frequency spectra (PS) and (iii) correlation between these findings, polygraphic (PG) and subjective scores along Dizziness Handicap Inventory (DHI) and Epworth Sleepiness Scale (ESS)...
March 20, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28315041/positive-pressure-ventilation-in-a-patient-with-a-right-upper-lobar-bronchocutaneous-fistula-right-upper-bronchus-occlusion-using-the-cuff-of-a-left-sided-double-lumen-endobronchial-tube
#2
Chieko Omori, Hiroaki Toyama, Yusuke Takei, Yutaka Ejima, Masanori Yamauchi
In patients with a bronchocutaneous fistula, positive pressure ventilation leads to air leakage and potential hypoxemia. A male patient with a right upper bronchocutaneous fistula was scheduled for esophageal reconstruction. His preoperative chest computed tomography image revealed aeration in the right middle and lower lobe, a large bulla in the left upper lobe, and pleural effusion and pneumonia in the left lower lobe. Therefore, left one-lung ventilation was considered to result in hypoxemia. Before anesthesia induction, the bronchocutaneous fistula was covered with gauze and film to prevent air leakage...
March 17, 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/28306607/orexin-a-aggravates-the-impairment-of-hippocampal-neurons-caused-by-intermittent-hypoxemia-by-the-oxr-plc%C3%AE-1-erk1-2-pathway
#3
Guohua Li, Shi Tang, Heng Chi, Weiwei Huang, Shanshan Lu, Xin Lv, Xiaomin Liu, Yan Li, Yanpeng Wang, Jiyou Tang
Obstructive sleep apnea is a highly prevalent but under-recognized disorder that causes neurocognitive deficits such as spatial memory and learning deficits. These deficits are frequently accompanied by an increase in orexin-A, which has been shown to be involved in learning and memory as well as in neuronal apoptosis in brain areas involved in cognition, such as the hippocampus. The aim of this work was to study the possible harmful effects of orexin-A on intermittent hypoxemia-induced hippocampal neuronal damage and to investigate the potential underlying molecular mechanisms and signaling pathways in vitro...
March 16, 2017: Neuroreport
https://www.readbyqxmd.com/read/28306414/cross-sectional-comparison-of-sleep-disordered-breathing-in-native-peruvian-highlanders-and-lowlanders
#4
Luu V Pham, Christopher Meinzen, Rafael S Arias, Noah G Schwartz, Adi Rattner, Catherine H Miele, Philip L Smith, Hartmut Schneider, J Jaime Miranda, Robert H Gilman, Vsevolod Y Polotsky, William Checkley, Alan R Schwartz
Pham, Luu V., Christopher Meinzen, Rafael S. Arias, Noah G. Schwartz, Adi Rattner, Catherine H. Miele, Philip L. Smith, Hartmut Schneider, J. Jaime Miranda, Robert H. Gilman, Vsevolod Y. Polotsky, William Checkley, and Alan R. Schwartz. Cross-sectional comparison of sleep-disordered breathing in native Peruvian highlanders and lowlanders. High Alt Med Biol. 18:11-19, 2017. BACKGROUND: Altitude can accentuate sleep disordered breathing (SDB), which has been linked to cardiovascular and metabolic diseases...
March 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28301945/the-utility-of-the-macro-aggregated-albumin-lung-perfusion-scan-in-the-diagnosis-and-prognosis-of-hepatopulmonary-syndrome-in-cirrhotic-patients-candidates-for-liver-transplantation
#5
Israel Grilo Bensusan, Juan Manuel Pascasio, Juan Luis Tirado, Francisco-Jesús López-Pardo, Francisco Ortega-Ruiz, José Manuel Sousa, María José Rodríguez-Puras, María Teresa Ferrer, Miguel Ángel Gómez-Bravo, Antonio Grilo Reina
BACKGROUND: The macro-aggregated albumin lung perfusion scan (99mTc-MAA) is a diagnostic method for hepatopulmonary syndrome (HPS). GOAL: To determine the sensitivity of 99mTc-MAA in diagnosing HPS, to establish the utility of 99mTc-MAA in determining the influence of HPS on hypoxemia in patients with concomitant pulmonary disease and to determine the correlation between 99mTc-MAA values and other respiratory parameters. METHODS: Data from 115 cirrhotic patients who were eligible for liver transplantation (LT) were prospectively analyzed...
March 17, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28298878/effect-of-high-flow-nasal-cannula-versus-conventional-oxygen-therapy-for-patients-with-thoracoscopic-lobectomy-after-extubation
#6
Yuetian Yu, Xiaozhe Qian, Chunyan Liu, Cheng Zhu
Objective. To investigate whether high-flow nasal cannula (HFNC) oxygen therapy is superior to conventional oxygen therapy for reducing hypoxemia and postoperative pulmonary complications (PPC) in patients with thoracoscopic lobectomy after extubation. Methods. Patients with intermediate to high risk for PPC were enrolled in this study. Subjects were randomly assigned to HFNC group (HFNCG) or conventional oxygen group (COG) following extubation. Arterial blood samples were collected after extubation at 1, 2, 6, 12, 24, 48, and 72 h...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/28296782/the-safety-and-efficacy-of-dexmedetomidine-remifentanil-in-children-undergoing-flexible-bronchoscopy-a-retrospective-dose-finding-trial
#7
Xia Li, Xue Wang, Shuguang Jin, Dongsheng Zhang, Yanuo Li
Flexible bronchoscopy is more and more used for diagnosis and management of various pulmonary diseases in pediatrics. As poor coordination of children, the procedure is usually performed under general anesthesia with spontaneous or controlled ventilation to increase children and bronchoscopists' safety and comfort. Previous studies have reported that dexmedetomidine (DEX) could be safely and effectively used for flexible bronchoscopy in both adulate and children. However, there is no trial to evaluate the dose-finding of safety and efficacy of dexmedetomidine-remifentanil (DEX-RF) in children undergoing flexible bronchoscopy...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28295572/dyspnea-following-thoracostomy-closure-after-right-pneumonectomy-an-uncommon-echocardiographic-diagnosis-and-therapeutic-approach
#8
Matteo Pernigo, Barbara Canneto, Davide Betta, Gionata Molinari, Flavio Ribichini, Guido Zannini, Corrado Vassanelli, Andrea Rossi
Dyspnea and hypoxemia are common postoperative problems after pneumonectomy. One of the rarer causes of respiratory distress after right pneumonectomy is the development of a significant right-to-left shunt across a patent foramen ovale (PFO), which can evolve at a variable interval of time after the operation. We report here our experience with a patient who underwent right pneumonectomy, followed by several complications, and who presented severe dyspnea 7 months later, after the closure of a right thoracostomy...
March 14, 2017: Echocardiography
https://www.readbyqxmd.com/read/28291872/increasing-hypoxemia-and-dyspnea-in-mild-chronic-obstructive-pulmonary-disease
#9
Boris Medarov, Haroon Chaudhry, Thomas Myint
No abstract text is available yet for this article.
March 14, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28291701/obstructive-sleep-apnea-exaggerates-cognitive-dysfunction-in-stroke-patients
#10
Yan Zhang, Wanhua Wang, Sijie Cai, Qi Sheng, Shenggui Pan, Fang Shen, Qing Tang, Yang Liu
BACKGROUND: Obstructive sleep apnea (OSA) is very common in stroke survivors. It potentially worsens the cognitive dysfunction and inhibits their functional recovery. However, whether OSA independently damages the cognitive function in stroke patients is unclear. A simple method for evaluating OSA-induced cognitive impairment is also missing. METHODS: Forty-four stroke patients six weeks after onset and 24 non-stroke patients with snoring were recruited for the polysomnographic study of OSA and sleep architecture...
February 4, 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28288035/spurious-hypoxemia-during-craniotomy
#11
Sukhbir Walha, Donald Penning
No abstract text is available yet for this article.
March 10, 2017: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/28287530/open-tracheostomy-gastric-acid-aspiration-murine-model-of-acute-lung-injury-results-in-maximal-acute-nonlethal-lung-injury
#12
Ravi Alluri, Hilliard L Kutscher, Barbara A Mullan, Bruce A Davidson, Paul R Knight
Acid pneumonitis is a major cause of sterile acute lung injury (ALI) in humans. Acid pneumonitis spans the clinical spectrum from asymptomatic to acute respiratory distress syndrome (ARDS), characterized by neutrophilic alveolitis, and injury to both alveolar epithelium and vascular endothelium. Clinically, ARDS is defined by acute onset of hypoxemia, bilateral patchy pulmonary infiltrates and non-cardiogenic pulmonary edema. Human studies have provided us with valuable information about the physiological and inflammatory changes in the lung caused by ARDS, which has led to various hypotheses about the underling mechanisms...
February 26, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28286654/it-s-better-to-be-lucky%C3%A2-%C3%A2-%C3%A2-successful-management-of-an-acute-endobronchial-tumour-embolism-in-the-icu-a-case-report-and-review-of-the-literature
#13
Christopher J Walsh, Ron Olivenstein, Eric Forget, Anne V Gonzalez
Endobronchial tumour embolism is a rare cause of acute central airway obstruction. It is primarily reported during pneumonectomy, and the outcome is frequently fatal. Successful management requires the urgent removal of tumour with rigid or flexible bronchoscopy. We present the case of a 62-year-old woman with poorly differentiated non-small cell lung cancer (NSCLC), referred to our institution for Nd:YAG laser photoresection of endobronchial tumour completely obstructing the right mainstem bronchus (RMSB)...
May 2017: Respirology Case Reports
https://www.readbyqxmd.com/read/28285391/very-small-embryonic-like-stem-cells-are-mobilized-in-human-peripheral-blood-during-hypoxemic-copd-exacerbations-and-pulmonary-hypertension
#14
Coralie L Guerin, Adeline Blandinières, Benjamin Planquette, Jean-Sébastien Silvestre, Dominique Israel-Biet, Olivier Sanchez, David M Smadja
Very small embryonic-like stem cells (VSELs) are major pluripotent stem cells involved in vascular and tissue regeneration and constitute a recruitable pool of stem/progenitor cells with putative instrumental role in organ repair. Here, we hypothesized that VSELs might be mobilized from the bone marrow (BM) to peripheral blood (PB) in patients with hypoxic lung disease or pulmonary hypertension (PH). The objective of the present study was then to investigate the changes in VSELs number in peripheral blood of patients with hypoxic lung disease and PH...
March 11, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28284316/the-effects-of-obesity-on-lung-volumes-and-oxygenation
#15
Stephen W Littleton, Aiman Tulaimat
INTRODUCTION: Obesity can cause hypoxemia by decreasing lung volumes to where there is closure of lung units during normal breathing. Studies describing this phenomenon are difficult to translate into clinical practice. We wanted to determine the lung volume measurements that are associated with hypoxemia in obese patients, and explore how we could use these measurements to identify them. METHODS: We collected pulmonary function test results and arterial blood gas data on 118 patients without obstruction on pulmonary function testing...
March 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28283176/usefulness-of-the-prenatal-echocardiogram-in-fetuses-with-isolated-transposition-of-the-great-arteries-to-predict-the-need-for-balloon-atrial-septostomy
#16
Trisha V Vigneswaran, Vita Zidere, Owen I Miller, John M Simpson, Gurleen K Sharland
The outcome of the arterial switch operation for transposition of the great arteries (TGA) is excellent, but there is still associated preoperative mortality. Hypoxemia due to inadequate mixing of the pulmonary and systemic circulations may be implicated. Prediction of early hypoxemia by prenatal echocardiographic criteria has proved difficult. We aimed to identify prenatal echocardiographic features that may predict the need for emergency balloon atrial septostomy (BAS) in isolated TGA. Third trimester fetal echocardiograms of the last 40 cases of isolated TGA were reviewed without knowledge of the postnatal outcome...
February 9, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28281094/clinical-features-and-inflammatory-markers-in-pediatric-pneumonia-a-prospective-study
#17
Are Stuwitz Berg, Christopher Stephen Inchley, Hans Olav Fjaerli, Truls Michael Leegaard, Morten Lindbaek, Britt Nakstad
In this prospective, observational study on previously healthy children <18 years, we aimed to study the diagnostic ability of clinical features and inflammatory markers to (i) predict pathologic chest radiography in suspected pneumonia and (ii) differentiate etiology in radiological proven pneumonia. In 394 cases of suspected pneumonia, 265 (67%) had radiographs consistent with pneumonia; 34/265 had proof of bacterial etiology. Of the cases, 86.5% had received pneumococcal conjugate vaccine. In suspected pneumonia, positive chest radiography was significantly associated with increasing C-reactive protein (CRP) values, higher age, and SpO2 ≤92% in multivariate logistic regression, OR 1...
March 9, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28279433/patterns-of-oxygenation-mortality-and-growth-status-in-the-surfactant-positive-pressure-and-oxygen-trial-cohort
#18
Juliann M Di Fiore, Richard J Martin, Hong Li, Nathan Morris, Waldemar A Carlo, Neil Finer, Michele Walsh
OBJECTIVE: To characterize actual achieved patterns of oxygenation in infants born appropriate vs small for gestational age (SGA) randomized to a lower (85-89%) vs higher (91%-95%) oxygen saturation target in the Surfactant Positive Pressure and Oxygen Trial. To determine the association between achieved oxygen saturation levels and survival in infants born appropriate vs SGA enrolled in the Surfactant Positive Pressure and Oxygen Trial. STUDY DESIGN: Median oxygen saturation and intermittent hypoxemia events (<80%, 20 seconds-5  minutes) were documented in 1054 infants of 24(0/7)-27(6/7) weeks of gestation while receiving supplemental oxygen during the first 3 days of life...
March 6, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28277372/one-hit-models-of-ventilator-induced-lung-injury-benign-inflammation-versus-inflammation-as-a-by-product
#19
Dennis Lex, Stefan Uhlig
BACKGROUND: One important explanation for the detrimental effects of conventional mechanical ventilation is the biotrauma hypothesis that ventilation may trigger proinflammatory responses that subsequently cause lung injury. This hypothesis has frequently been studied in so-called one-hit models (overventilation of healthy lungs) that so far have failed to establish an unequivocal link between inflammation and hypoxemic lung failure. This study was designed to develop a one-hit biotrauma model...
March 9, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28272068/rare-disease-heralded-by-pulmonary-manifestations-avoiding-pitfalls-of-an-asthma-label
#20
S Bajaj, M Muranjan, S Karande, D Prabhat
Pulmonary manifestations are seldom recognized as symptoms of storage disorders. The report describes the diagnostic journey in a 30-month-old male infant, born of a third-degree consanguineous marriage referred to our institute as severe persistent asthma. History revealed that the child had progressively worsening breathlessness and persistent dry cough not associated with fever but accompanied by weight loss. On physical examination, there was growth failure, respiratory distress, clubbing, hepatosplenomegaly, and occasional rhonchi...
March 3, 2017: Journal of Postgraduate Medicine
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