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https://www.readbyqxmd.com/read/28938066/systematic-optimization-of-battery-materials-key-parameter-optimization-for-the-scalable-synthesis-of-uniform-high-energy-and-high-stability-lini0-6mn0-2co0-2o2-cathode-material-for-lithium-ion-batteries
#1
Dong Ren, Yun Shen, Yao Yang, Luxi Shen, Barnaby D A Levin, Yingchao Yu, David A Muller, Héctor D Abruña
Ni-rich LiNixMnyCo1-x-yO2 (x>0.5) (NMC) materials have attracted a great deal of interest as promising cathode candidates for Li-ion batteries (LIBs) due to their low cost and high energy density. However, several issues, including sensitivity to moisture, difficulty in reproducibly preparing well-controlled morphology particles and, poor cyclability, have hindered their large scale deployment; especially for electric vehicle (EV) applications. In this work, we have developed a uniform, highly stable, high-energy density, Ni-rich LiNi0...
September 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28936924/expression-of-cross-tolerance-to-a-wide-range-of-conditions-in-a-human-lung-cancer-cell-line-after-adaptation-to-nitric-oxide
#2
Zane Deliu, Timothy Tamas, Juel Chowdhury, Madeeha Aqil, Maaly Bassiony, James A Radosevich
Previously, we have shown that A549, a human lung adenocarcinoma, can be adapted to nitric oxide (NO(●)). NO(●) is a nitrogen-based free radical that is synthesized by a family of enzymes known as nitric oxide synthases. NO(●) has been shown to be overexpressed in patient populations of different cancers. In addition, it has been observed that patients who express high levels of nitric oxide synthases tend to have poorer clinical outcomes than those with low levels of expression. The original cell line A549 (parent) and the adapted A549-HNO (high nitric oxide) cell line serve as a useful model system to investigate the role of NO(●) in tumor progression and prognosis...
September 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28931538/modulators-of-actin-myosin-dissociation-basis-for-muscle-type-functional-differences-during-fatigue
#3
Christina Karatzaferi, Nancy Adamek, Michael A Geeves
The muscle types present with variable fatigue tolerance, in part due to the myosin isoform expressed. However, the critical steps that define 'fatigability' in vivo of fast vs slow myosin isoforms, at the molecular level, are not yet fully understood. We examined the modulation of the ATP-induced myosin sub-fragment 1 (S1) dissociation from pyrene-actin by inorganic phosphate (Pi), pH and temperature using a specially modified stopped-flow system that allowed fast kinetics measurements at physiological temperature...
September 20, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28924033/rgpf-is-required-for-maintenance-of-stress-tolerance-and-virulence-in-streptococcus-mutans
#4
C J Kovacs, R C Faustoferri, R G Quivey
Bacterial cell wall dynamics have been implicated as important determinants of cellular physiology, stress tolerance and virulence. In Streptococcus mutans, the cell wall is composed primarily of a rhamnose-glucose polysaccharide (RGP) linked to the peptidoglycan. Despite extensive studies describing its formation and composition, the potential roles for RGP in S. mutans biology have not been well investigated. The present study characterizes the impact of RGP disruption as a result of deletion of rgpF, the gene encoding a rhamnosyltransferase involved in construction of the core poly-rhamnose backbone of RGP...
September 18, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28911641/evaluation-of-the-prebiotic-effects-of-citrus-pectin-hydrolysate
#5
Yen-Yi Ho, Chia-Min Lin, Ming-Chang Wu
Citrus pectin enzyme hydrolysate (PEH) of different hydrolysis time intervals (6 hours, PEH-6; 12 hours, PEH-12; 24 hours, PEH-24; or 48 hours, PEH-48) or concentrations (1%, 2%, and 4%) was tested for its growth stimulation effect on two probiotics, Bifidobacterium bifidum and Lactobacillus acidophilus. Higher monosaccharide concentrations and smaller molecular weights of PEHs were obtained by prolonging the hydrolysis time. In addition, higher PEH concentrations resulted in significantly higher (p < 0...
July 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28904563/bacillus-coagulans-ma-13-a-promising-thermophilic-and-cellulolytic-strain-for-the-production-of-lactic-acid-from-lignocellulosic-hydrolysate
#6
Martina Aulitto, Salvatore Fusco, Simonetta Bartolucci, Carl Johan Franzén, Patrizia Contursi
BACKGROUND: The transition from a petroleum-based economy towards more sustainable bioprocesses for the production of fuels and chemicals (circular economy) is necessary to alleviate the impact of anthropic activities on the global ecosystem. Lignocellulosic biomass-derived sugars are suitable alternative feedstocks that can be fermented or biochemically converted to value-added products. An example is lactic acid, which is an essential chemical for the production of polylactic acid, a biodegradable bioplastic...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28902865/optimization-of-the-expression-purification-and-polymerase-activity-reaction-conditions-of-recombinant-human-primpol
#7
Elizaveta O Boldinova, Gorazd Stojkovič, Rafil Khairullin, Sjoerd Wanrooij, Alena V Makarova
Human PrimPol is a DNA primase/polymerase involved in DNA damage tolerance and prevents nuclear genome instability. PrimPol is also localized to the mitochondria, but its precise function in mitochondrial DNA maintenance has remained elusive. PrimPol works both as a translesion (TLS) polymerase and as the primase that restarts DNA replication after a lesion. However, the observed biochemical activities of PrimPol vary considerably between studies as a result of different reaction conditions used. To reveal the effects of reaction composition on PrimPol DNA polymerase activity, we tested the polymerase activity in the presence of various buffer agents, salt concentrations, pH values and metal cofactors...
2017: PloS One
https://www.readbyqxmd.com/read/28898428/soil-co2-venting-as-one-of-the-mechanisms-for-tolerance-of-zn-deficiency-by-rice-in-flooded-soils
#8
Marie-Cecile Affholder, Dominik J Weiss, Matthias Wissuwa, Sarah E Johnson-Beebout, Guy J D Kirk
We sought to explain rice (Oryza sativa) genotype differences in tolerance of zinc (Zn) deficiency in flooded paddy soils and the counter-intuitive observation, made in earlier field experiments, that Zn uptake per plant increases with increasing planting density. We grew tolerant and intolerant genotypes in a Zn-deficient flooded soil at high and low planting densities, and found (a) plant Zn concentrations and growth increased with planting density and more so in the tolerant genotype, whereas the concentrations of other nutrients decreased, indicating a specific effect on Zn uptake; (b) the effects of planting density and genotype on Zn uptake could only be explained if the plants induced changes in the soil to make Zn more soluble; and (c) the genotype and planting density effects were both associated with decreases in dissolved CO2 in the rhizosphere soil solution and resulting increases in pH...
September 12, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28891399/response-of-human-fetal-liver-progenitor-cell-types-to-temperature-and-ph-stresses-in-vitro
#9
Eva Schmelzer, Hubert G Foka, Robert L Thompson, Angelo Luca, Bruno Gridelli, Jörg C Gerlach
Prolonged physiological stresses including abnormal pH and temperature are deleterious. Yet, human hepatic progenitors have been shown to be quite tolerant of temporary temperature stress such as in cold ischemia. We aimed to identify how various stresses affect liver progenitors, and to determine whether distinct effects exist on different progenitor cells of the human liver. Total fetal liver cells were exposed to low (25°C), normal (37°C), or high (40°C) temperatures, or low (6.76), normal (7.35), or high (7...
September 11, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28887953/synthesis-and-biological-evaluation-of-an-anticancer-drug-delivery-system-poly-l-%C3%AE-glutamyl-l-carbocisteine-paclitaxel-nanoconjugate
#10
Lin Han, Ye Xiao, Mingxue Fan, Jing Wang, Zhiqiang Yan, Yiting Wang, Lei Yu, Hui Peng, Jianzhong Zhu
This study is intended to develop and evaluate a novel, highly water-soluble polymer drug conjugate poly(l-γ-glutamyl-l-carbocisteine)-paclitaxel (PGSC-PTX) which can trigger drug release in tumor acidic microenvironment and improve the therapeutic index of paclitaxel (PTX). PGSC-PTX is formed by introducing an additional carbocisteine into each glutamic side chain of poly(l-glutamic acid)-paclitaxel (PGA-PTX) conjugate. PGSC-PTX self-assembles into nanoparticles, whose size remains in the range of 15-20nm...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28884067/optimization-of-thermostable-organic-solvent-tolerant-lipase-production-by-thermotolerant-rhizopus-sp-using-solid-state-fermentation-of-palm-kernel-cake
#11
Fatimah Azizah Riyadi, Md Zahangir Alam, Md Noor Salleh, Hamzah Mohd Salleh
This study enhanced the production of thermostable organic solvent-tolerant (TS-OST) lipase by locally isolated thermotolerant Rhizopus sp. strain using solid-state fermentation (SSF) of palm kernel cake (PKC). The optimum conditions were achieved using a series of statistical approaches. The cultivation parameters, which include fermentation time, moisture content, temperature, pH, inoculum size, various carbon and nitrogen sources, as well as other supplements, were initially screened by the definitive screening design, and one-factor-at-a-time using PKC as the basal medium...
October 2017: 3 Biotech
https://www.readbyqxmd.com/read/28871850/succinoglycan-production-contributes-to-acidic-ph-tolerance-in-sinorhizobium-meliloti-rm1021
#12
Justin P Hawkins, Barney A Geddes, Ivan John Oresnik
In this work, the hypothesis that exopolysaccharide plays a role in the survival of S. meliloti at low pH is addressed. When S. meliloti was grown at pH 5.75 the synthesis of succinoglycan increased, whereas the synthesis of galactoglucan decreased. Succinoglycan that was isolated from cultures grown at low pH had a lower degree of polymerization relative to that which was isolated from cultures grown at neutral pH, suggesting that low molecular weight (LMW) succinoglycan might play a role in adaptation to low pH...
September 5, 2017: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/28867349/engineering-escherichia-coli-membrane-phospholipid-head-distribution-improves-tolerance-and-production-of-biorenewables
#13
Zaigao Tan, Pouyan Khakbaz, Yingxi Chen, Jeremy Lombardo, Jong Moon Yoon, Jacqueline V Shanks, Jeffery B Klauda, Laura R Jarboe
Economically competitive microbial production of biorenewable fuels and chemicals is often impeded by toxicity of the product to the microbe. Membrane damage is often identified as a major mechanism of this toxicity. Prior efforts to strengthen the microbial membrane by changing the phospholipid distribution have largely focused on the fatty acid tails. Herein, a novel strategy of phospholipid head engineering is demonstrated in Escherichia coli. Specifically, increasing the expression of phosphatidylserine synthase (+pssA) was found to significantly increase both the tolerance and production of octanoic acid, a representative membrane-damaging solvent...
September 1, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/28862331/selection-and-use-of-indigenous-mixed-starter-cultures-for-mustard-leaves-fermentation-and-the-improvement-of-cuocai-characteristics
#14
Xuan Chen, Miao Zheng, Jia Liu, Zeyuan Deng, Bing Zhang, Hongyan Li
BACKGROUND: To improve the characteristic and safety of traditional cuocai, the selection and us of mixed starter cultures is important. This work was aimed to isolate the main indigenous LAB and yeast species from spontaneous fermented mustard leaves, and they were used as starter cultures to ferment mustard leaves. RESULTS: Five predominant lactic acid bacteria (LAB) including Q-1 (Enterococcus faecalis), G-1 (Lactobacillus plantarum), G-3 (Lactobacillus pentosus), G-2 and G-4 (Lactobacillus buchneri)strains and two yeast strains including J-1 (Issatchenkia orientalis) and J-2 (Issatchenkia occidentalis)strains were isolated from cuocai...
September 1, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28860063/production-of-a-thermostable-1-3-1-4-%C3%AE-glucanase-mutant-in-bacillus-subtilis-wb600-at-a-high-fermentation-capacity-and-its-potential-application-in-the-brewing-industry
#15
Chengtuo Niu, Chunfeng Liu, Yongxian Li, Feiyun Zheng, Jinjing Wang, Qi Li
1,3-1,4-β-glucanase was an important biotechnological aid in the brewing industry. In a previous research, a Bacillus BglTO mutant (BglTO) with high tolerance towards high temperature and low-pH conditions was constructed and expressed in Escherichia coli. However, E. coli was not a suitable host for enzyme production in food industry. Therefore, the present work aimed to achieve the high-level expression of BglTO in Bacillus subtilis WB600 and to test its effect in Congress mashing. The β-glucanase mutant was successfully expressed in B...
August 28, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28852016/the-histidine-rich-peptide-lah4-l1-strongly-promotes-pamam-mediated-transfection-at-low-nitrogen-to-phosphorus-ratios-in-the-presence-of-serum
#16
Nan Liu, Burkhard Bechinger, Regine Süss
Non-viral vectors are widely used and investigated for the delivery of genetic material into cells. However, gene delivery barriers like lysosomal degradation, serum inhibition and transient gene expression so far still limit their clinical applications. Aiming to overcome these limitations, a pH-sensitive hybrid gene vector (PSL complex) was designed by self-assembly of poly(amidoamine) (PAMAM) dendrimers, the histidine-rich peptide LAH4-L1 and the sleeping beauty transposon system (SB transposon system, a plasmid system capable of efficient and precise genomic insertion)...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28851819/o2-binding-and-co2-sensitivity-in-hemoglobins-of-subterranean-african-mole-rats
#17
Roy E Weber, Jennifer U M Jarvis, Angela Fago, Nigel C Bennett
Inhabiting deep and sealed subterranean burrows, mole rats exhibit a remarkable suite of specializations, including eusociality (living in colonies with single breeding queens), extraordinary longevity, cancer immunity and poikilothermy, and extreme tolerance of hypoxia and hypercapnia.With little information available on adjustments in hemoglobin (Hb) function that may mitigate the impact of exogenous and endogenous constraints on the uptake and internal transport of O2, we measured hematological characteristics, as well as Hb-O2 binding affinities and their sensitivities to pH (Bohr effect), CO2, temperature and 2,3 diphosphoglycerate (DPG, the major allosteric modulator of Hb-O2 affinity in the red cells) in four social and two solitary species of African mole rats (family Bathyergidae) originating from different biomes and soil types across Central and Southern Africa...
August 29, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28842677/gschx19-3-a-member-of-cation-h-exchanger-superfamily-from-wild-soybean-contributes-to-high-salinity-and-carbonate-alkaline-tolerance
#18
Bowei Jia, Mingzhe Sun, Huizi DuanMu, Xiaodong Ding, Beidong Liu, Yanming Zhu, Xiaoli Sun
Cation/H(+) exchangers (CHX) are characterized to be involved in plant growth, development and stress responses. Although soybean genome sequencing has been completed, the CHX family hasn't yet been systematically analyzed, especially in wild soybean. Here, through Hidden Markov Model search against Glycine soja proteome, 34 GsCHXs were identified and phylogenetically clustered into five groups. Members within each group showed high conservation in motif architecture. Interestingly, according to our previous RNA-seq data, only Group IVa members exhibited highly induced expression under carbonate alkaline stress...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28836171/in-vitro-characterization-of-lactobacillus-strains-isolated-from-fruit-processing-by-products-as-potential-probiotics
#19
Thatyane Mariano Rodrigues de Albuquerque, Estefânia Fernandes Garcia, Amanda de Oliveira Araújo, Marciane Magnani, Maria Saarela, Evandro Leite de Souza
Nine wild Lactobacillus strains, namely Lactobacillus plantarum 53, Lactobacillus fermentum 56, L. fermentum 60, Lactobacillus paracasei 106, L. fermentum 250, L. fermentum 263, L. fermentum 139, L. fermentum 141, and L. fermentum 296, isolated from fruit processing by-products were evaluated in vitro for a series of safety, physiological functionality, and technological properties that could enable their use as probiotics. Considering the safety aspects, the resistance to antibiotics varied among the examined strains, and none of the strains presented hemolytic and mucinolytic activity...
August 23, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28829024/tundrisphaera-lichenicola-gen-nov-sp-nov-a-psychrotolerant-representative-of-the-family-isosphaeraceae-from-lichen-dominated-tundra-soils
#20
Irina S Kulichevskaya, Anastasia A Ivanova, Ekaterina N Detkova, W Irene C Rijpstra, Jaap S Sinninghe Damsté, Svetlana N Dedysh
Two strains of aerobic, budding, pink-pigmented bacteria, P12T and P515, were isolated from a lichen-dominated peatland and a forested tundra soil of north-western Siberia, respectively. Cells of these isolates were represented by non-motile spheres that occurred singly or were arranged in short chains and aggregates. While growing on solid media, cells of strains P12T and P515 attached to the surface by means of holdfast-like appendages. These isolates were mildly acidophilic (optimum growth at pH 5.5-6.0), psychrotolerant bacteria, which displayed tolerance of low temperatures (4-15 °C), grew optimally at 15-22 °C and did not grow at temperatures above 28 °C...
September 2017: International Journal of Systematic and Evolutionary Microbiology
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