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https://www.readbyqxmd.com/read/28035659/is-there-a-role-of-food-additives-in-recurrent-aphthous-stomatitis-a-prospective-study-with-patch-testing
#1
Duygu Gülseren, Asli Hapa, Sibel Ersoy-Evans, Gonca Elçin, Ayşen Karaduman
BACKGROUND: Recurrent aphthous stomatitis (RAS) is a common disease of the oral mucosa with an unknown etiology. This study aimed to determine if food additives play a role in the etiology of RAS as well as to determine if patch testing can be used to detect which allergens cause RAS. METHODS: This prospective study included 24 patients with RAS and 22 healthy controls. All the participants underwent patch testing for 23 food additives. RESULTS: In total, 21 (87...
December 30, 2016: International Journal of Dermatology
https://www.readbyqxmd.com/read/28025453/preparation-of-a-ammonia-treated-lac-dye-and-structure-elucidation-of-its-main-component
#2
Yuzo Nishizaki, Kyoko Ishizuki, Hiroshi Akiyama, Atsuko Tada, Naoki Sugimoto, Kyoko Sato
Lac dye and cochineal extract contain laccaic acids and carminic acid as the main pigments, respectively. Both laccaic acids and carminic acid are anthraquinone derivatives. 4-Aminocarminic acid (acid-stable carmine), an illegal colorant, has been detected in several processed foods. 4-Aminocarminic acid is obtained by heating cochineal extract (carminic acid) in ammonia solution. We attempted to prepare ammonia-treated lac dye and to identify the structures of the main pigment components. Ammonia-treated lac dye showed acid stability similar to that of 4-aminocarminic acid...
2016: Shokuhin Eiseigaku Zasshi. Journal of the Food Hygienic Society of Japan
https://www.readbyqxmd.com/read/28008236/communicating-laboratory-test-results-for-rheumatoid-factor-what-do-patients-and-physicians-want
#3
Ariella Kelman, Caroline O Robinson, Elisenda Cochin, Nina J Ahluwalia, Julia Braverman, Emil Chiauzzi, Kristina Simacek
OBJECTIVE: This study aimed to explore patient and physician perspectives on current laboratory test reporting practices and to elicit ideas for improvement. METHODS: Two independent studies were conducted. The first solicited members of an online physician community for opinions on current laboratory test reporting practices and possible improvements. The second addressed the same topic, but solicited patient feedback, and included an evaluation of a mock laboratory test report for the rheumatoid factor blood test...
2016: Patient Preference and Adherence
https://www.readbyqxmd.com/read/27986812/barbiturates-bind-in-the-glic-ion-channel-pore-and-cause-inhibition-by-stabilizing-a-closed-state
#4
Zaineb Fourati, Reinis Reinholds Ruza, Duncan Laverty, Emmanuelle Drège, Sandrine Delarue-Cochin, Delphine Joseph, Patrice Koehl, Trevor Smart, Marc Delarue
Barbiturates induce anesthesia by modulating the activity of anionic and cationic pentameric ligand-gated ion channels (pLGICs). Despite more than a century of use in clinical practice, the prototypic binding site for this class of drugs within pLGICs is yet to be described. In this study, we present the first X-ray structures of barbiturates bound to GLIC, a cationic prokaryotic pLGIC with excellent structural homology to other relevant channels sensitive to general anesthetics and, as shown here, to barbiturates, at clinically-relevant concentrations...
December 16, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27863736/moberg-picking-up-test-in-patients-with-hand-osteoarthritis
#5
Paula Gabriel Silva, Anamaria Jones, Artur da Rocha Correa Fernandes, Jamil Natour
STUDY DESIGN: Clinical measurement. INTRODUCTION: The Moberg Pick-up Test (MPUT) was previously used to evaluate functional performance in patients with hand inflammatory disease. This is the first study using the MPUT in hand osteoarthritis (OA). PURPOSE OF THE STUDY: Compare the functional performance (MPUT) in hand OA patients and healthy controls. METHODS: Fifty hand OA patients and 50 controls were assessed using the MPUT, AUSCAN and Cochin questionnaires, grip and pinch strength, pain using a visual analog scale and a Likert scale regarding difficulty to perform MPUT...
November 15, 2016: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/27799431/virtuous-colours-for-mary-identification-of-lapis-lazuli-smalt-and-cochineal-in-the-andean-colonial-image-of-our-lady-of-copacabana-bolivia
#6
Eugenia P Tomasini, Fernando Marte, Valeria P Careaga, Carlos Rúa Landa, Gabriela Siracusano, Marta S Maier
The image of Our Lady of Copacabana, a gilded polychrome sculpture carved in maguey wood in 1583, is one of the most important devotions in the Americas. In former research, we have identified the use of gypsum, Armenian bole, cerussite and atacamite in its polychromy. In this study, a red sample taken from the Virgin's tunic and a blue sample extracted from the cloak have been analysed with the aim to identify both pigments and offer insights into the painting technique. Analysis by micro-Raman spectroscopy complemented with scanning electron microscopy-energy dispersive spectroscopy and high-performance liquid chromatography allowed the identification of carmine lake in the red sample...
December 13, 2016: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/27788121/correction-of-exploring-concordance-of-patient-reported-information-on-patientslikeme-and-medical-claims-data-at-the-patient-level
#7
Gabriel S Eichler, Elisenda Cochin, Jian Han, Sylvia Hu, Timothy E Vaughan, Paul Wicks, Charles Barr, Jenny Devenport
[This corrects the article DOI: 10.2196/jmir.5130.].
October 27, 2016: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/27749237/mri-and-serum-biomarkers-correlate-with-radiographic-features-in-painful-hand-osteoarthritis
#8
Christian H Roux, Violaine Foltz, Emmanuel Maheu, Gabriel Baron, Frederique Gandjbakhch, Cédric Lukas, Daniel Wendling, Damien Loeuille, Pierre Lafforgue, Liana Euler-Ziegler, Pascal Richette, Xavier Chevalier
OBJECTIVES: To explore the relationship between clinical findings, biologic biomarkers, conventional radiography and MRI in patients with painful hand OA. METHODS: The following patient baseline data from the DORA study (evaluating anti-TNF-α agents against painful hand OA) were used: clinical assessment (pain, swelling, stiffness and function: Dreiser functional hand index [FIHOA] and Cochin hand functional scale [CHFS]); measurement of biomarkers (cartilage oligomeric matrix protein (COMP), type IIA collagen N-propeptid (PIINP), hyaluronic acid (HA), ultrasensitive C-reactive protein (usCRP), tumour necrosis factor (TNF), interleukin (IL)-6, IL-1β and urinary CTXII); radiological staging (Verbruggen, Kallman, Kellgren-Lawrence); anatomical evaluation by contrast-enhanced MRI of proximal and distal interphalangeal joints of dominant hand...
November 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27729110/dynamics-of-polycyclic-aromatic-hydrocarbons-pahs-in-surface-sediments-of-cochin-estuary-india
#9
A Ramzi, K Habeeb Rahman, T R Gireeshkumar, K K Balachandran, Chacko Jacob, N Chandramohanakumar
Polycyclic aromatic hydrocarbons (PAHs) showed significant seasonal dynamics in surface sediments of a tropical ecosystem (Cochin estuary, south west coast of India). Concentrations ranged from 304 to 5874ngg(-1) in pre-monsoon, 493 to 14,149ngg(-1) in monsoon, and 194 to 10,691ngg(-1) in post-monsoon. The estuary was moderately contaminated with low molecular weight PAH fractions, which increased rapidly during the monsoon season indicating land/river runoff as the major transport pathway. The dominance of 2-3 ring fractions in the PAH indicated petrogenic and low temperature combustion processes as major sources, while the very low levels of 5-6 ring components indicated low contribution from pyrolytic sources...
October 8, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27689232/scale-insect-larvae-preserved-in-vertebrate-coprolites-le-quesnoy-france-lower-eocene-paleoecological-insights
#10
Ninon Robin, Imre Foldi, Marc Godinot, Gilles Petit
Coprolites of terrestrial vertebrates from the Sparnacian Le Quesnoy locality (Ypresian, Eocene, MP7, 53 Ma; Oise, France) were examined for possible parasitic helminth eggs. The extraction of the coprolite components was performed by a weak acetolyse and a slide mounting in glycerin. This long examination did not reveal paleoparasite remains, which may be explained through several arguments. However, some pollen grains, some enigmatic components, and two well-preserved first-instar cochineal nymphs (Hemiptera: Sternorrhyncha: Coccoidea) were evidenced in coprolites...
October 2016: Die Naturwissenschaften
https://www.readbyqxmd.com/read/27614959/copepod-carcasses-in-a-tropical-estuary-during-different-hydrographical-settings
#11
R Jyothibabu, L Jagadeesan, K R Lallu
Dead copepods (carcasses) are widespread in aquatic systems, but their scientific quantification is rare due to the difficulty in discriminating them from live ones. In this paper, we hypothesized that due to large spatial and temporal changes in hydrography in the Cochin backwaters, the percentage of copepod carcasses in the system could also change significantly on a spatial and temporal scale. In order to understand this aspect, we quantified the live and dead copepods in the Cochin backwaters under different hydrographical settings based on live and mortal staining technique...
October 2015: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/27584140/changes-over-time-and-responsiveness-of-the-cochin-hand-function-scale-and-mouth-handicap-in-systemic-sclerosis-scale-in-patients-with-systemic-sclerosis-a-prospective-observational-study
#12
Christelle Nguyen, Alice Bérezné, Caroline Mestre-Stanislas, Marie-Martine Lefèvre-Colau, François Rannou, Loïc Guillevin, Luc Mouthon, Serge Poiraudeau
OBJECTIVE: To assess changes over time and responsiveness of the Cochin Hand Function Scale (CHFS) and Mouth Handicap In Systemic Sclerosis (MHISS) scale in patients with systemic sclerosis (SSc). DESIGN: This was a prospective longitudinal study. PARTICIPANTS: Participants were drawn from a convenience sample of individuals with SSc, who were attending the annual Congress of the Association des Sclérodermiques de France, the French SSc patients' association...
December 2016: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/27581681/biosynthesis-and-characterization-of-silver-nanoparticles-prepared-from-two-novel-natural-precursors-by-facile-thermal-decomposition-methods
#13
Mojgan Goudarzi, Noshin Mir, Mehdi Mousavi-Kamazani, Samira Bagheri, Masoud Salavati-Niasari
In this work, two natural sources, including pomegranate peel extract and cochineal dye were employed for the synthesis of silver nanoparticles. The natural silver complex from pomegranate peel extract resulted in nano-sized structures through solution-phase method, but this method was not efficient for cochineal dye-silver precursor and the as-formed products were highly agglomerated. Therefore, an alternative facile solid-state approach was investigated as for both natural precursors and the results showed successful production of well-dispersed nanoparticles with narrow size distribution for cochineal dye-silver precursor...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27552359/bioinspired-design-and-oriented-synthesis-of-immunogenic-site-specifically-penicilloylated-peptides
#14
Noémie Scornet, Sandrine Delarue-Cochin, Marie Eliane Azoury, Maxime Le Mignon, Julie-Anne Chemelle, Emmanuel Nony, Bernard Maillère, Raphaël Terreux, Marc Pallardy, Delphine Joseph
β-Lactam antibiotics allergy is recognized as a public health concern. By covalently binding to serum proteins, penicillins are known to form immunogenic complexes. The latter are recognized and digested by antigen-presenting cells into drug-hapten peptides leading to the immunization of treated persons and IgE-mediated hypersensitivity reactions encompassing anaphylaxis. If type I allergic reactions to drugs are often unpredictable, they are known to be dependent on CD4(+) T-cells. This fundamental study revisits the chemical basis of the benzylpenicillin (BP) allergy with the aim of identifying immunologically relevant biomimetic benzylpenicilloylated peptides through the analysis of BP-conjugated human serum albumin (BP-HSA) profile and the evaluation of the naı̈ve CD4(+) T-cell responses to candidate BP-HSA-derived peptides...
November 16, 2016: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/27543297/genomes-of-candidatus-wolbachia-bourtzisii-wdaca-and-candidatus-wolbachia-pipientis-wdacb-from-the-cochineal-insect-dactylopius-coccus-hemiptera-dactylopiidae
#15
Shamayim T Ramírez-Puebla, Ernesto Ormeño-Orrillo, Arturo Vera-Ponce de León, Luis Lozano, Alejandro Sanchez-Flores, Mónica Rosenblueth, Esperanza Martínez-Romero
Dactylopius species, known as cochineal insects, are the source of the carminic acid dye used worldwide. The presence of two Wolbachia strains in Dactylopius coccus from Mexico was revealed by PCR amplification of wsp and sequencing of 16S rRNA genes. A metagenome analysis recovered the genome sequences of Candidatus Wolbachia bourtzisii wDacA (supergroup A) and Candidatus Wolbachia pipientis wDacB (supergroup B). Genome read coverage, as well as 16S rRNA clone sequencing, revealed that wDacB was more abundant than wDacA...
October 13, 2016: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/27527795/genetic-risk-factors-for-antiepileptic-drug-induced-hypersensitivity-reactions-in-israeli-populations
#16
Shoshana Israel, Nicola Maggio, Dana Ekstein, Huda Zaid, Maria Firer, Yana Bederovsky, Iris Noyman, Revital Gandelman-Marton, Ilan Blatt, Chaim Brautbar, Eli Marom, Dorit Nahlieli Dil, Erez Berman, David Sabag, Arieh Ingber, Sara Eyal
The human leukocyte antigen (HLA) alleles B*15:02 and A*31:01 have been identified as predictive markers of adverse cutaneous effects of carbamazepine and phenytoin in Asian and North European populations, respectively. Our aim was to estimate the distribution of these alleles in Jewish and Arab populations in Israel. The HLA-B*15:02 and HLA-A*31:01 carrier rate was estimated based on data from the Hadassah Bone Marrow Registry. Data on Stevens-Johnson syndrome (SJS)- and toxic epidermal necrolysis (TEN)-related hospitalizations were obtained from the Israeli Ministry of Health (MOH) registries and from four Israeli medical centers...
October 2016: Epilepsia
https://www.readbyqxmd.com/read/27446001/fungal-community-associated-with-dactylopius-hemiptera-coccoidea-dactylopiidae-and-its-role-in-uric-acid-metabolism
#17
Arturo Vera-Ponce de León, Alejandro Sanchez-Flores, Mónica Rosenblueth, Esperanza Martínez-Romero
We studied fungal species associated with the carmine cochineal Dactylopius coccus and other non-domesticated Dactylopius species using culture-dependent and -independent methods. Thirty seven fungi were isolated in various culture media from insect males and females from different developmental stages and Dactylopius species. 26S rRNA genes and ITS sequences, from cultured fungal isolates revealed different species of Cryptococcus, Rhodotorula, Debaryomyces, Trametes, and Penicillium, which are genera newly associated with Dactylopius...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27402873/validation-of-disease-activity-indices-using-the-28-joint-counts-in-systemic-sclerosis
#18
Veronika Lóránd, Zsófia Bálint, Dalma Komjáti, Balázs Németh, Tünde Minier, Gábor Kumánovics, Nelli Farkas, László Czirják, Cecília Varjú
OBJECTIVES: To validate the Disease Activity Score 28 using ESR (DAS28-ESR) and CRP (DAS28-CRP), the Simplified Disease Activity Index and the Clinical Disease Activity Index used in RA for SSc patients. METHODS: Seventy-seven SSc patients, 40 RA patients, 20 patients with primary RP (PRP) and 28 healthy volunteers were assessed. Besides the disease activity composite indices, the European Scleroderma Study Group Activity Index (EScSG-AI), the HAQ-DI, the Cochin Hand Function Scale and the Short Form Health Survey (SF36) were evaluated...
October 2016: Rheumatology
https://www.readbyqxmd.com/read/27377974/the-genetic-history-of-cochin-jews-from-india
#19
Yedael Y Waldman, Arjun Biddanda, Maya Dubrovsky, Christopher L Campbell, Carole Oddoux, Eitan Friedman, Gil Atzmon, Eran Halperin, Harry Ostrer, Alon Keinan
Cochin Jews form a small and unique community on the Malabar coast in southwest India. While the arrival time of any putative Jewish ancestors of the community has been speculated to have taken place as far back as biblical times (King Solomon's era), a Jewish community in the Malabar coast has been documented only since the 9th century CE. Here, we explore the genetic history of Cochin Jews by collecting and genotyping 21 community members and combining the data with that of 707 individuals from 72 other Indian, Jewish, and Pakistani populations, together with additional individuals from worldwide populations...
October 2016: Human Genetics
https://www.readbyqxmd.com/read/27271883/pancreatitis-in-children
#20
REVIEW
Malathi Sathiyasekaran, Vishnu Biradar, Ganesh Ramaswamy, S Srinivas, B Ashish, B Sumathi, D Nirmala, M Geetha
Pancreatic disease in children has a wide clinical spectrum and may present as Acute pancreatitis (AP), Acute recurrent pancreatitis (ARP), Chronic pancreatitis (CP) and Pancreatic disease without pancreatitis. This article highlights the etiopathogenesis and management of pancreatitis in children along with clinical data from five tertiary care hospitals in south India [Chennai (3), Cochin and Pune].
November 2016: Indian Journal of Pediatrics
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