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Christian H Roux, Violaine Foltz, Emmanuel Maheu, Gabriel Baron, Frederique Gandjbakhch, Cédric Lukas, Daniel Wendling, Damien Loeuille, Pierre Lafforgue, Liana Euler-Ziegler, Pascal Richette, Xavier Chevalier
OBJECTIVES: To explore the relationship between clinical findings, biologic biomarkers, conventional radiography and MRI in patients with painful hand OA. METHODS: The following patient baseline data from the DORA study (evaluating anti-TNF-α agents against painful hand OA) were used: clinical assessment (pain, swelling, stiffness and function: Dreiser functional hand index [FIHOA] and Cochin hand functional scale [CHFS]); measurement of biomarkers (cartilage oligomeric matrix protein (COMP), type IIA collagen N-propeptid (PIINP), hyaluronic acid (HA), ultrasensitive C-reactive protein (usCRP), tumour necrosis factor (TNF), interleukin (IL)-6, IL-1β and urinary CTXII); radiological staging (Verbruggen, Kallman, Kellgren-Lawrence); anatomical evaluation by contrast-enhanced MRI of proximal and distal interphalangeal joints of dominant hand...
September 18, 2016: Clinical and Experimental Rheumatology
A Ramzi, K Habeeb Rahman, T R Gireeshkumar, K K Balachandran, Chacko Jacob, N Chandramohanakumar
Polycyclic aromatic hydrocarbons (PAHs) showed significant seasonal dynamics in surface sediments of a tropical ecosystem (Cochin estuary, south west coast of India). Concentrations ranged from 304 to 5874ngg(-1) in pre-monsoon, 493 to 14,149ngg(-1) in monsoon, and 194 to 10,691ngg(-1) in post-monsoon. The estuary was moderately contaminated with low molecular weight PAH fractions, which increased rapidly during the monsoon season indicating land/river runoff as the major transport pathway. The dominance of 2-3 ring fractions in the PAH indicated petrogenic and low temperature combustion processes as major sources, while the very low levels of 5-6 ring components indicated low contribution from pyrolytic sources...
October 8, 2016: Marine Pollution Bulletin
Ninon Robin, Imre Foldi, Marc Godinot, Gilles Petit
Coprolites of terrestrial vertebrates from the Sparnacian Le Quesnoy locality (Ypresian, Eocene, MP7, 53 Ma; Oise, France) were examined for possible parasitic helminth eggs. The extraction of the coprolite components was performed by a weak acetolyse and a slide mounting in glycerin. This long examination did not reveal paleoparasite remains, which may be explained through several arguments. However, some pollen grains, some enigmatic components, and two well-preserved first-instar cochineal nymphs (Hemiptera: Sternorrhyncha: Coccoidea) were evidenced in coprolites...
October 2016: Die Naturwissenschaften
R Jyothibabu, L Jagadeesan, K R Lallu
Dead copepods (carcasses) are widespread in aquatic systems, but their scientific quantification is rare due to the difficulty in discriminating them from live ones. In this paper, we hypothesized that due to large spatial and temporal changes in hydrography in the Cochin backwaters, the percentage of copepod carcasses in the system could also change significantly on a spatial and temporal scale. In order to understand this aspect, we quantified the live and dead copepods in the Cochin backwaters under different hydrographical settings based on live and mortal staining technique...
October 2015: Environmental Monitoring and Assessment
Christelle Nguyen, Alice Bérezné, Caroline Mestre-Stanislas, Marie-Martine Lefèvre-Colau, François Rannou, Loïc Guillevin, Luc Mouthon, Serge Poiraudeau
OBJECTIVE: To assess changes over time and responsiveness of the Cochin Hand Function Scale (CHFS) and Mouth Handicap In Systemic Sclerosis (MHISS) scale in patients with systemic sclerosis (SSc). DESIGN: This was a prospective longitudinal study. PARTICIPANTS: Participants were drawn from a convenience sample of individuals with SSc, who were attending the annual Congress of the Association des Sclérodermiques de France, the French SSc patients' association...
August 31, 2016: American Journal of Physical Medicine & Rehabilitation
Mojgan Goudarzi, Noshin Mir, Mehdi Mousavi-Kamazani, Samira Bagheri, Masoud Salavati-Niasari
In this work, two natural sources, including pomegranate peel extract and cochineal dye were employed for the synthesis of silver nanoparticles. The natural silver complex from pomegranate peel extract resulted in nano-sized structures through solution-phase method, but this method was not efficient for cochineal dye-silver precursor and the as-formed products were highly agglomerated. Therefore, an alternative facile solid-state approach was investigated as for both natural precursors and the results showed successful production of well-dispersed nanoparticles with narrow size distribution for cochineal dye-silver precursor...
2016: Scientific Reports
Noémie Scornet, Sandrine Delarue-Cochin, Marie-Eliane Azoury, Maxime Le Mignon, Julie-Anne Chemelle, Emmanuel Nony, Bernard Maillere, Raphael Terreux, Marc Pallardy, Delphine Joseph
β-Lactam antibiotics allergy is recognized as a public health concern. By covalently binding to serum proteins, penicillins are known to form immunogenic complexes. The latter are recognized and digested by antigen-presenting cells into drug-hapten peptides leading to the immunization of treated persons and IgE-mediated hypersensitivity reactions encompassing anaphylaxis. If type I allergic reactions to drugs are often unpredictable, they are known to be dependent on CD4+ T-cells. This fundamental study revisits the chemical basis of the benzylpenicillin (BP) allergy with the aim of identifying immunologically relevant biomimetic benzylpenicilloylated peptides through the analysis of BP-conjugated human serum albumin (BP-HSA) profile and the evaluation of the naïve CD4+ T-cell responses to candidate BP-HSA-derived peptides...
August 23, 2016: Bioconjugate Chemistry
Shamayim T Ramírez-Puebla, Ernesto Ormeño-Orrillo, Arturo Vera-Ponce de León, Luis Lozano, Alejandro Sanchez-Flores, Mónica Rosenblueth, Esperanza Martínez-Romero
Dactylopius species, known as cochineal insects, are the source of the carminic acid dye used worldwide. The presence of two Wolbachia strains in Dactylopius coccus from Mexico was revealed by PCR amplification of wsp and sequencing of 16S rRNA genes. A metagenome analysis recovered the genome sequences of Candidatus Wolbachia bourtzisii wDacA (supergroup A) and Candidatus Wolbachia pipientis wDacB (supergroup B). Genome read coverage, as well as 16S rRNA clone sequencing, revealed that wDacB was more abundant than wDacA...
October 13, 2016: G3: Genes—Genomes—Genetics
Shoshana Israel, Nicola Maggio, Dana Ekstein, Huda Zaid, Maria Firer, Yana Bederovsky, Iris Noyman, Revital Gandelman-Marton, Ilan Blatt, Chaim Brautbar, Eli Marom, Dorit Nahlieli Dil, Erez Berman, David Sabag, Arieh Ingber, Sara Eyal
The human leukocyte antigen (HLA) alleles B*15:02 and A*31:01 have been identified as predictive markers of adverse cutaneous effects of carbamazepine and phenytoin in Asian and North European populations, respectively. Our aim was to estimate the distribution of these alleles in Jewish and Arab populations in Israel. The HLA-B*15:02 and HLA-A*31:01 carrier rate was estimated based on data from the Hadassah Bone Marrow Registry. Data on Stevens-Johnson syndrome (SJS)- and toxic epidermal necrolysis (TEN)-related hospitalizations were obtained from the Israeli Ministry of Health (MOH) registries and from four Israeli medical centers...
October 2016: Epilepsia
Arturo Vera-Ponce de León, Alejandro Sanchez-Flores, Mónica Rosenblueth, Esperanza Martínez-Romero
We studied fungal species associated with the carmine cochineal Dactylopius coccus and other non-domesticated Dactylopius species using culture-dependent and -independent methods. Thirty seven fungi were isolated in various culture media from insect males and females from different developmental stages and Dactylopius species. 26S rRNA genes and ITS sequences, from cultured fungal isolates revealed different species of Cryptococcus, Rhodotorula, Debaryomyces, Trametes, and Penicillium, which are genera newly associated with Dactylopius...
2016: Frontiers in Microbiology
Veronika Lóránd, Zsófia Bálint, Dalma Komjáti, Balázs Németh, Tünde Minier, Gábor Kumánovics, Nelli Farkas, László Czirják, Cecília Varjú
OBJECTIVES: To validate the Disease Activity Score 28 using ESR (DAS28-ESR) and CRP (DAS28-CRP), the Simplified Disease Activity Index and the Clinical Disease Activity Index used in RA for SSc patients. METHODS: Seventy-seven SSc patients, 40 RA patients, 20 patients with primary RP (PRP) and 28 healthy volunteers were assessed. Besides the disease activity composite indices, the European Scleroderma Study Group Activity Index (EScSG-AI), the HAQ-DI, the Cochin Hand Function Scale and the Short Form Health Survey (SF36) were evaluated...
October 2016: Rheumatology
Yedael Y Waldman, Arjun Biddanda, Maya Dubrovsky, Christopher L Campbell, Carole Oddoux, Eitan Friedman, Gil Atzmon, Eran Halperin, Harry Ostrer, Alon Keinan
Cochin Jews form a small and unique community on the Malabar coast in southwest India. While the arrival time of any putative Jewish ancestors of the community has been speculated to have taken place as far back as biblical times (King Solomon's era), a Jewish community in the Malabar coast has been documented only since the 9th century CE. Here, we explore the genetic history of Cochin Jews by collecting and genotyping 21 community members and combining the data with that of 707 individuals from 72 other Indian, Jewish, and Pakistani populations, together with additional individuals from worldwide populations...
October 2016: Human Genetics
Malathi Sathiyasekaran, Vishnu Biradar, Ganesh Ramaswamy, S Srinivas, B Ashish, B Sumathi, D Nirmala, M Geetha
Pancreatic disease in children has a wide clinical spectrum and may present as Acute pancreatitis (AP), Acute recurrent pancreatitis (ARP), Chronic pancreatitis (CP) and Pancreatic disease without pancreatitis. This article highlights the etiopathogenesis and management of pancreatitis in children along with clinical data from five tertiary care hospitals in south India [Chennai (3), Cochin and Pune].
June 6, 2016: Indian Journal of Pediatrics
Gabriel S Eichler, Elisenda Cochin, Jian Han, Sylvia Hu, Timothy E Vaughan, Paul Wicks, Charles Barr, Jenny Devenport
BACKGROUND: With the emergence of data generated by patient-powered research networks, it is informative to characterize their correspondence with health care system-generated data. OBJECTIVES: This study explored the linking of 2 disparate sources of real-world data: patient-reported data from a patient-powered research network (PatientsLikeMe) and insurance claims. METHODS: Active patients within the PatientsLikeMe community, residing in the United States, aged 18 years or older, with a self-reported diagnosis of multiple sclerosis or Parkinson's disease (PD) were invited to participate during a 2-week period in December 2014...
2016: Journal of Medical Internet Research
Marie-Laure Raffin-Sanson, Gwenaelle Abiven, Katrin Ritzel, Pauline de Corbière, Laure Cazabat, Ramona Zaharia, Lionel Groussin, Rossella Libe, Jérôme Bertherat, Martin Fassnacht, Xavier Bertagna
Adrenocortical carcinoma is a rare cancer with a poor but heterogeneous prognosis. These tumours are more frequently encountered in women, sometimes very young and may be diagnosed in women in their child bearing years or already pregnant. Several clinical data have indicated that the secretion and or proliferation of adrenocortical tumors may be affected by the hormonal context of pregnancy. In this review, we will examine the link between ACC and pregnancy in two main aspects. We will first consider the situation of a pregnant woman with a clinical suspicion of adrenocortical carcinoma: which diagnostic procedures will be useful and safe for the foetus? What are the therapeutic options? What is the prognosis if the diagnosis is confirmed? In a second part, we will examine the possible risk of mothering a child in a patient previously treated for an ACC...
June 2016: Annales D'endocrinologie
Emil Chiauzzi, Pronabesh DasMahapatra, Elisenda Cochin, Mikele Bunce, Raya Khoury, Purav Dave
BACKGROUND: Providers and healthcare organizations have begun recognizing the importance of patient empowerment as a driver of patient-centered care. Unfortunately, most studies have investigated empowerment with single diseases. Identifying factors of empowerment across conditions and populations would enable a greater understanding of this construct. OBJECTIVE: The purpose of this study was to understand empowerment in relation to health information-seeking, interactions with providers and peers, and healthcare access in chronic disease patients...
May 7, 2016: Patient
Anas Abdulaziz, Saliha Sageer, Jasmin Chekidhenkuzhiyil, Vijitha Vijayan, Pratheesh Pavanan, Sujith Athiyanathil, Shanta Nair
The interactions between heterotrophic bacteria and primary producers have a profound impact on the functioning of marine ecosystem. We characterized the enzymatic and metal resistance properties of fourteen heterotrophic bacteria isolated from a unicellular cyanobacterium Synechocystis sp. that came from a heavy metal contaminated region of Cochin estuary, southwest coast of India. Based on 16S rRNA gene sequence similarities, the heterotrophic bacteria were grouped into three phyla: namely Actinobacteria, Firmicute, and Proteobacteria...
August 2016: Journal of Basic Microbiology
A Vincent-Rohfritsch, A Marszalek, P Santulli, V Gayet, C Chapron, F Goffinet, C Le Ray
OBJECTIVES: In France, egg donation is covered by Social insurance among women<43 years old. Because of shortage of egg donor, women aged 43 years or more cannot resort to egg donation in French infertility centers, leading them to turn to the foreign centers having practices different and less regulated than in France. We are thus brought to take care of the pregnancy and of the delivery of these women. Our objective was to estimate if the perinatal risks are more important after egg donation abroad than in case of egg donation in a French center...
April 12, 2016: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
Laetitia Fend, Christelle Remy-Ziller, Johann Foloppe, Juliette Kempf, Sandrine Cochin, Luc Barraud, Nathalie Accart, Philippe Erbs, Sylvie Fournel, Xavier Préville
Oncolytic virotherapy is an emergent promising therapeutic approach for the treatment of cancer. We have constructed a vaccinia virus (WR strain) deleted for thymidine kinase (TK) and ribonucleotide reductase (RR) genes that expressed the fusion suicide gene FCU1 derived from the yeast cytosine deaminase and uracil phosphoribosyltransferase genes. We evaluated this construct (VV-FCU1) in the orthotopic model of renal carcinoma (RenCa). Systemic administration of VV-FCU1 resulted in orthotopic tumor growth inhibition, despite temporary expression of viral proteins...
February 2016: Oncoimmunology
J A Cruz-Rodríguez, E González-Machorro, A A Villegas González, M L Rodríguez Ramírez, F Mejía Lara
It is broadly known that the conservation of biological diversity in agricultural ecosystems contributes to pest control. This process was studied in a prickly pear plantation (Opuntia megacanthaandOpuntia ficus-indica) located in central Mexico. No insecticides have been used on this plantation since 2000, and local farmers believe that the presence of different species of insects limits the growth of the wild cochineal (Dactylopius opuntiaeCockerell), which is one of the main pests in this crop. From August 2012 to November 2013, we estimated the number of cochineal per stem in the plantation and determined its spatial distribution pattern...
April 7, 2016: Environmental Entomology
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