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https://www.readbyqxmd.com/read/29150153/-dermatologic-surgery-hemophilia-and-von-willebrand-disease
#1
M Say, N Dupin, N Stieltjes, M-F Avril, S Aractingi, J Chanal
BACKGROUND: Von Willebrand disease (VWD) and hemophilia A and B are the most common types of hereditary coagulation-factor deficiencies. The frequency and type of complications of skin surgery in these patients are unknown. The increasing incidence of skin cancer prompted us to reflect upon this issue. While the incidence of skin cancer is increasing, the complications of skin surgery or ablative laser treatment remain unknown in this population. AIM: The aim of this study was to determine the frequency of bleeding complications during and after skin surgery in patients with a hereditary coagulation-factor deficiency (hemophilia or VWD)...
November 14, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29102156/systematic-switch-from-innovator-infliximab-to-biosimilar-infliximab-in-inflammatory-chronic-diseases-in-daily-clinical-practice-the-experience-of-cochin-university-hospital-paris-france
#2
Jérôme Avouac, Anna Moltó, Vered Abitbol, Adrien Etcheto, Axelle Salcion, Loriane Gutermann, Caroline Klotz, Muriel Elhai, Pascal Cohen, Pierre Antoine Soret, Florence Morin, Ornella Conort, François Chast, Claire Goulvestre, Claire Le Jeunne, Stanislas Chaussade, André Kahan, Christian Roux, Yannick Allanore, Maxime Dougados
OBJECTIVE: To investigate effectiveness of systematic switching treatment from innovator infliximab to biosimilar infliximab, and its associated factors. METHODS: In this prospective observational study, all adult patients receiving maintenance therapy with innovator infliximab in Cochin University Hospital were systematically switched to biosimilar infliximab. Effectiveness was assessed by the retention rate of biosimilar infliximab at the time of the third infusion...
October 5, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29047006/extended-culture-of-poor-quality-supernumerary-embryos-improves-art-outcomes
#3
Amira Sallem, Pietro Santulli, Virginie Barraud-Lange, Nathalie Le Foll, Lucile Ferreux, Chloé Maignien, Mathilde Bourdon, Charles Chapron, Dominique de Ziegler, Jean-Philippe Wolf, Khaled Pocate-Cheriet
PURPOSE: The aims of this study were to investigate the possible benefits of extending the culture of poor-quality day-2 embryos (PQE) versus good-quality embryos (GQE) and to identify factors associated with pregnancy and live birth when transferring frozen-thawed blastocysts originating from GQE and PQE. METHODS: This is a retrospective cohort follow-up study performed between November 2012 and February 2015 at the IVF Laboratory Unit of Cochin University Hospital (Paris, France) including 3108 day-2 supernumerary embryos resulting from 1237 IVF/ICSI cycles...
October 18, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28992165/points-to-consider-for-designing-trials-in-systemic-sclerosis-patients-with-arthritic-involvement
#4
REVIEW
Philip Clements, Yannick Allanore, Daniel E Furst, Dinesh Khanna
Although musculoskeletal involvement is quite common in SSc (arthritic in particular), there have been few trials and even fewer controlled trials of therapeutic agents in arthritis in SSc. In addition, there have been only three outcome measures that have been validated for use in trials of SSc arthritis: the HAQ Disability Index, the Cochin Hand Function Scale and the Hand Mobility in SSc scale. The purpose of this article is to present evidence-based points to consider for the design of trials in SSc patients with musculoskeletal involvement (joints in particular)...
September 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28988502/reassessing-the-species-status-of-pseudodiaptomus-malayalus-wellershaus-1969-and-p-binghami-sewell-1912-calanoida-pseudodiaptomidae-from-india-based-on-morphology-and-mitochondrial-cytochrome-oxidase-i-gene-sequences
#5
K S Santu, S Bijoy Nandan, Retina I Cleetus, M Harikrishnan
Pseudodiaptomus binghami Sewell, 1912 was first described from the Rangoon River (now Yangon River) estuary, Myanmar. Pseudodiaptomus malayalus Wellershaus, 1969 previously known as P. binghami malayalus, is a typical brackish-water calanoid copepod from Cochin Estuary, Kerala. Morphological examination of P. malayalus and P. binghami collected from Cochin Estuary and the Nambur canal in Andhra Pradesh revealed crucial differences between the two congeners. Female specimens of P. malayalus exhibited marked differences from those described by Wellershaus...
October 9, 2017: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/28963632/optimisation-of-critical-medium-components-and-culture-conditions-for-enhanced-biomass-and-lipid-production-in-the-oleaginous-diatom-navicula-phyllepta-a-statistical-approach
#6
Sanyo Sabu, Isaac Sarojini Bright Singh, Valsamma Joseph
Diatoms hold great promise as potential sources of biofuel production. In the present study, the biomass and lipid production in the marine diatom Navicula phyllepta, isolated from Cochin estuary, India and identified as a potential biodiesel feedstock, were optimized using Plackett-Burman (PB) statistical experimental design followed by central composite design (CCD) and response surface methodology (RSM). The growth analyses of the isolate in different nitrogen sources, salinities and five different enriched sea water media showed the best growth in the cheapest medium with minimum components using urea as nitrogen source at salinity between 25 and 40 g kg(-1)...
September 29, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28951885/cowpox-virus-a-new-and-armed-oncolytic-poxvirus
#7
Marine Ricordel, Johann Foloppe, Christelle Pichon, Nathalie Sfrontato, Delphine Antoine, Caroline Tosch, Sandrine Cochin, Pascale Cordier, Eric Quemeneur, Christelle Camus-Bouclainville, Stéphane Bertagnoli, Philippe Erbs
Oncolytic virus therapy has recently been recognized as a promising new therapeutic approach for cancer treatment. In this study, we are proposing for the first time to evaluate the in vitro and in vivo oncolytic capacities of the Cowpox virus (CPXV). To improve the tumor selectivity and oncolytic activity, we developed a thymidine kinase (TK)-deleted CPXV expressing the suicide gene FCU1, which converts the non-toxic prodrug 5-fluorocytosine (5-FC) into cytotoxic 5-fluorouracil (5-FU) and 5-fluorouridine-5'-monophosphate (5-FUMP)...
December 15, 2017: Molecular Therapy Oncolytics
https://www.readbyqxmd.com/read/28919528/modification-of-wool-protein-fiber-with-plasma-and-dendrimer-effects-on-dyeing-with-cochineal
#8
Toktam Sajed, Aminoddin Haji, Mohammad Khajeh Mehrizi, Majid Nasiri Boroumand
In this study, plasma treatment and a poly(propylene imine) dendrimer were employed to improve the dyeability of wool fibers with cochineal natural dye. FESEM, EDX, AFM and FTIR techniques were employed to investigate the effects of these treatments on chemical and physical properties of wool fibers. The etching of surface layer of wool fibers and increased roughness after plasma treatment was confirmed by FESEM and AFM images. EDX and FTIR analyses confirmed the creation of oxygen-containing groups and attachment of dendrimer molecules on wool fibers after plasma and dendrimer treatments respectively...
September 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28869417/efficacy-of-intensive-hand-physical-therapy-in-patients-with-systemic-sclerosis
#9
József Horváth, Zsófia Bálint, Erika Szép, Aletta Deiszinger, Tünde Minier, Nelli Farkas, Enikő Török, Éva Horváthné Papp, Dalma Komjáti, Zsuzsanna Mándó, László Czirják, Cecilia Varjú
OBJECTIVES: To evaluate the efficacy of a three-week period of complex and intensive hand physical therapy on hand function in patients with systemic sclerosis (SSc). METHODS: Thirty-one patients with SSc were treated. Hand stretching exercises, ergotherapy supplemented with thermal and mud baths, whirlpool therapy and soft tissue massage were daily used during a three-week period. The control SSc group (n=22) received similar management for their large joints leaving out their hands...
August 30, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28843898/role-of-heavy-metals-in-structuring-the-microbial-community-associated-with-particulate-matter-in-a-tropical-estuary
#10
V A Sheeba, Anas Abdulaziz, T R Gireeshkumar, Anirudh Ram, P S Rakesh, C Jasmin, P S Parameswaran
Particulate matter (PM), which are chemically and biochemically complicated particles, accommodate a plethora of microorganisms. In the present study, we report the influence of heavy metal pollution on the abundance and community structure of archaea and bacteria associated with PM samples collected from polluted and non-polluted regions of Cochin Estuary (CE), Southwest coast of India. We observed an accumulation of heavy metals in PM collected from CE, and their concentrations were in the order Fe > Zn > Mn > Cr > Pb > Cu > Cd > Co > Ni...
December 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28816192/tobacco-abuse-and-associated-oral-lesions-among-interstate-migrant-construction-workers
#11
Anzil Ks Ali, Arshad Mohammed, Archana A Thomas, Shann Paul, M Shahul, K Kasim
AIM: The present study was conducted to assess the prevalence of tobacco use and associated oral mucosal lesions among construction workers of Cochin, Kerala, India. MATERIALS AND METHODS: A cross-sectional study was carried at various construction sites of Cochin and 2,163 workers were selected using multistage sampling method and were interviewed and examined. Information regarding demographic details, form, type, frequency of tobacco use, earlier attempt to quit, and willingness to quit tobacco use was obtained using predesigned questionnaire...
August 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28689093/immune-checkpoint-inhibitors-and-elderly-people-a%C3%A2-review
#12
REVIEW
Amaury Daste, Charlotte Domblides, Marine Gross-Goupil, Camille Chakiba, Amandine Quivy, Valérie Cochin, Erwan de Mones, Nicolas Larmonier, Pierre Soubeyran, Alain Ravaud
Immune checkpoint inhibitors, including targeting programmed cell death 1, programmed cell death ligand 1, and cytotoxic T lymphocyte antigen 4 pathways, are a new type of cancer treatment. This approach of targeting the immune system has demonstrated dramatic efficacy for several cancers, and various drugs have been approved by health authorities and are used in clinical practice. Elderly patients (≥65 years) represent most of the cancers diagnosed and deaths by age group, with an increase expected over the next decade...
September 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28674282/spiroketalcarminic-acid-a-novel-minor-anthraquinone-pigment-in-cochineal-extract-used-in-food-additives
#13
Yusai Ito, Naoki Harikai, Kyoko Ishizuki, Kazufusa Shinomiya, Naoki Sugimoto, Hiroshi Akiyama
Cochineal extract prepared from the scale insect Dactylopus coccus (American cochineal) has been used as a natural red dye for food, cosmetics, and pharmaceuticals. The major pigment in cochineal extract is carminic acid (CA), an anthraquinone glucoside, and several minor pigments have been previously reported. Our investigation aimed at establishing the safety of cochineal dye products using ultra performance liquid chromatography-photo diode array-electrospray ionization-time of flight (UPLC-PDA-ESI-TOF)/MS found an unknown minor pigment, spiroketalcarminic acid (1), in three commercial cochineal extract samples; cochineal extract used in food additives, carmine that is an aluminum salt of cochineal extract used as natural dye, and a research reagent of CA...
September 1, 2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28668262/-contribution-of-reflectance-confocal-microscopy-in-the-diagnosis-of-uterine-cervix-melanoma-first-case-report
#14
J L Perrot, B Labeille, E Richard Coulet, S Cochin, A-C Biron Schneider, P Rubegni, F Cambazard, E Cinotti
No abstract text is available yet for this article.
June 28, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28588564/viral-induced-mortality-of-prokaryotes-in-a-tropical-monsoonal-estuary
#15
Vijayan Jasna, Ammini Parvathi, Angia Sriram Pradeep Ram, Kizhekkapat K Balachandran, Nikathil V Madhu, Maheswari Nair, Retnamma Jyothibabu, K Veeraraghava Jayalakshmy, Chenicherry Revichandran, Télesphore Sime-Ngando
Viruses are recognized as the most abundant and dynamic biological entities in the marine and estuarine environment. However, studies on the dynamics and activity of viruses in transient estuarine systems are limited. This study examines temporal and spatial variations in viral abundance (VA) and viral activity across the salinity gradient in a monsoon-driven tropical estuarine system (Cochin estuary, CE) along the southwest coast of India. Water samples were collected from five stations (with different hydrological settings) every 3 h for 24 h period during two distinct seasons, namely pre-monsoon (PRM, dry season) and monsoon (MON, wet season)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28552572/drug-interaction-with-sunitinib-and-the-evidence-of-therapeutic-drug-monitoring-a-case-report-and-review-of-the-literature
#16
Pauline Bertolaso, Marine Gross-Goupil, Mathieu Molimard, Valérie Cochin, Alain Ravaud, Amaury Daste
No abstract text is available yet for this article.
May 10, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28434666/heavy-metal-distribution-and-contamination-status-in-the-sedimentary-environment-of-cochin-estuary
#17
P M Salas, C H Sujatha, C S Ratheesh Kumar, Eldhose Cheriyan
Heavy metals (Fe, Mn, Cr, Zn, Ni, Pb, Cu, Co and Cd) in the surface sediments of Cochin estuary, Southwest coast of India were analyzed to understand the spatio-temporal variation and contamination status via six sampling campaigns. Pollution indices like enrichment factor, geoaccumulation index and pollution load index inferred that the sediments of the northern arm of the estuary exhibited severe trace metal accumulation. Numerical sediment quality guidelines were applied to assess adverse biological effects of the trace metals, suggesting that occasional biological effect may occur due to Cr, Cu, Ni and Pb...
April 20, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28340695/long-term-follow-up-after-autologous-adipose-derived-stromal-vascular-fraction-injection-into-fingers-in-systemic-sclerosis-patients
#18
A Daumas, J Magalon, E Jouve, R Truillet, D Casanova, L Giraudo, J Veran, A Benyamine, F Dignat-George, G Magalon, F Sabatier, B Granel
INTRODUCTION: Hand involvement confers a substantial handicap in work and daily activities in patients with Systemic sclerosis (SSc). Autologous adipose-derived stromal vascular fraction is as an easily accessible source of cells with regenerative effects. We previously performed a phase I open-label clinical trial (NTC01813279) assessing the safety of subcutaneous injection of autologous adipose-derived stromal vascular fraction. Six and 12-month data have been reported. As patients were followed in our medical centre, we report their longer-term outcome beyond the end of the trial...
January 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/28250351/kinetic-study-of-the-equilibration-between-carminic-acid-and-its-two-isomers-isolated-from-cochineal-dye
#19
Kazumasa Zaima, Azusa Fukamachi, Ryoko Yagi, Yusai Ito, Naoki Sugimoto, Hiroshi Akiyama, Kazufusa Shinomiya, Naoki Harikai
Carminic acid (CA) is a major component of cochineal dye used in food additives, cosmetics, and pharmaceuticals. CA and its isomers, 2-C-α-glucofuranoside and 2-C-β-glucofuranoside of kermesic acid (DCIV and DCVII, respectively), were isolated from cochineal dye and the equilibrium constants (K) between CA, DCIV and DCVII were investigated. DCIV was partially converted to CA and DCVII, and DCVII was converted to CA and DCIV, whereas CA was very stable and only very slightly converted to DCIV and DCVII. Most of the DCIV and DCVII was converted to CA under aqueous conditions...
2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28214014/controlling-the-digital-ulcerative-disease-in-systemic-sclerosis-is-associated-with-improved-hand-function
#20
Luc Mouthon, Patrick H Carpentier, Catherine Lok, Pierre Clerson, Virginie Gressin, Eric Hachulla, Alice Bérezné, Elisabeth Diot, Aurélie Khau Van Kien, Patrick Jego, Christian Agard, Anne-Bénédicte Duval-Modeste, Agnès Sparsa, Eve Puzenat, Marie-Aleth Richard
OBJECTIVES: Ischemic digital ulcers (DU) represent a major complication of systemic sclerosis (SSc). We investigated the impact of controlling the ulcerative disease on disability, pain, and quality of life in SSc patients receiving bosentan. METHODS: ECLIPSE (Study AC-052-517) is a 2-year prospective, multicenter, and observational study. Patients with SSc who experienced at least 1 DU in the previous year and received bosentan were included between October 2009 and March 2011...
January 13, 2017: Seminars in Arthritis and Rheumatism
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