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https://www.readbyqxmd.com/read/29231742/interactions-and-supramolecular-organization-of-sulfonated-indigo-and-thioindigo-dyes-in-layered-hydroxide-hosts
#1
Ana Luisa Costa, Ana C Gomes, Ricardo Costa Pereira, Martyn Pillinger, Isabel Sousa Gonçalves, Marta Pineiro, J Sérgio Seixas de Melo
Supramolecularly organized host-guest systems have been synthesized by intercalating water-soluble forms of indigo (indigo carmine, IC) and thioindigo (thioindigo-5,5'-disulfonate, TIS) in zinc-aluminum layered double hydroxides (LDHs) and zinc layered hydroxide salts (LHSs) by coprecipitation routes. The colors of the isolated powders were dark blue for hybrids containing only IC, purplish blue or dark lilac for cointercalated samples containing both dyes, and ruby/wine for hybrids containing only TIS. As-synthesized and thermally treated materials were characterized by FT-IR, FT-Raman and NMR spectroscopies, powder X-ray diffraction, SEM, elemental and thermogravimetric analyses...
December 12, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29231727/an-anthracene-incorporated-8-cycloparaphenylene-derivative-as-emitter-in-photon-upconversion
#2
Paolo Della Sala, Amedeo Capobianco, Tonino Caruso, Carmen Talotta, Margherita De Rosa, Placido Neri, Andrea Peluso, Carmine Gaeta
The anthracene-incorporated [8]cycloparaphenylene 2 has been synthesized and its optoelectronic properties studied by UV-vis spectroscopy, cyclic voltammetry, and DFT calculations. NMR and computational studies indicate that the new cycloparaphenylene derivative possesses Cs point group symmetry. The new CPP 2 exhibits peculiar optoelectronic properties: i) fluorescence emission is blue shifted with respect to [8]cycloparaphenylene 1 and its quantum yield is higher; ii) in the presence of the octaethylporphyrin Pd complex as sensitizer, it undergoes visible light upconversion, the first case in which a cycloparaphenylene derivative is involved as emitter in low power light frequency conversion...
December 12, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29225852/physical-rehabilitation-modulates-micrornas-involved-in-multiple-sclerosis-a-case-report
#3
Annamaria Vallelunga, Carmine Berlingieri, Marco Ragusa, Michele Purrello, Maria Rosaria Stabile, Maria Consiglia Calabrese, Julio Cesar Morales-Medina, Beniamino Palmieri, Tommaso Iannitti
This study shows that neuromuscular taping improves gait, balance, pain and ability to walk and conduct daily activities in a multiple sclerosis patient. It is the first study to identify a panel of miRNAs modulated throughout rehabilitation using neuromuscular taping in a multiple sclerosis patient.
December 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29222505/a-comparison-of-methods-to-measure-central-and-peripheral-oxytocin-concentrations-in-human-and-non-human-primates
#4
Arthur Lefevre, Raphaëlle Mottolese, Manon Dirheimer, Carmine Mottolese, Jean-René Duhamel, Angela Sirigu
Oxytocin (OT) concentration in the blood is considered to be a marker of its action in the brain. However, two problems have emerged when measuring OT level in the blood. First, it is unclear whether different methods of assessment lead to similar OT values. Second, it is unclear if plasma OT concentrations is informative on what OT does in the brain. To clarify these issues, we collected cerebrospinal fluid (CSF) from the brain ventricle of 25 patients during surgery to compare with plasma OT after simultaneous blood withdrawal...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29217322/incidence-of-ureterovesical-obstruction-and-cohen-antireflux-surgery-after-deflux%C3%A2-treatment-for-vesicoureteric-reflux
#5
Manabu Okawada, Hiroshi Murakami, Nana Tanaka, Yuki Ogasawara, Geoffrey J Lane, Tadaharu Okazaki, Toshihiro Yanai, Masahiko Urao, Atsuyuki Yamataka
AIM: The purpose of this study was to determine the incidence of ureteric obstruction (UB) and requirement for Cohen antireflux surgery (CAS) after DefluxⓇ treatment (DT) for vesicoureteric reflux (VUR). METHODS: Between 2011 and 2017, 494 ureters (VUR severity ≤ grade III: N=291 or >grade IV: N=203) were treated by DT at a mean age of 4.5 (range: 0.2-24) years. Epidural Catheter Assistance (ECA) was used to exclude UB by injecting diluted indigo carmine solution (1-3mL) into an epidural catheter inserted into a ureter after DT and confirming dye flow within 15min...
November 14, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29215546/initial-tadalafil-and-ambrisentan-combination-therapy-in-pulmonary-arterial-hypertension-clinical-and-haemodynamic-long-term-efficacy-italy-study
#6
Michele D'Alto, Emanuele Romeo, Paola Argiento, Giuseppe Paciocco, Renato Prediletto, Stefano Ghio, Michele Correale, Francesco Lo Giudice, Roberto Badagliacca, Alessandra Greco, Carmine Dario Vizza
AIMS: Initial combination therapy with ambrisentan and tadalafil (upfront therapy) offers clinical benefits in pulmonary arterial hypertension (PAH) and reduces the risk of clinical failure compared with monotherapy in naïve patients. The aim of study is to assess the efficacy of a 12-month upfront therapy with ambrisentan and tadalafil in improving haemodynamics in incident PAH patients. METHODS: This is a multicentre retrospective analysis of real-world Italian clinical data in 56 patients with newly diagnosed PAH...
January 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29215389/horizontal-gaze-palsy-with-progressive-scoliosis-two-novel-robo3-mutations-in-a-compound-heterozygous-sporadic-case
#7
Carmine Ungaro, Sergio Valentini, Antonio Cerasa, Pier Luigi Lanza, Rosalucia Mazzei
No abstract text is available yet for this article.
December 5, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29215080/risk-predictors-and-outcomes-of-acute-kidney-injury-in-patients-admitted-to-intensive-care-units-in-egypt
#8
Samar Abd ElHafeez, Giovanni Tripepi, Robert Quinn, Yasmine Naga, Sherif Abdelmonem, Mohamed AbdelHady, Ping Liu, Matthew James, Carmine Zoccali, Pietro Ravani
Epidemiology of acute kidney injury (AKI) in developing countries is under-studied. We evaluated the risk and prognosis of AKI in patients admitted to intensive care units (ICUs) in Egypt. We recruited consecutive adults admitted to ICUs in Alexandria Teaching Hospitals over six months. We used the KDIGO criteria for AKI. We followed participants until the earliest of ICU discharge, death, day 30 from entry or study end. Of the 532 participants (median age 45 (Interquartile range [IQR]: 30-62) years, 41.7% male, 23...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29215010/characterization-of-a-membrane-bound-c-glucosyltransferase-responsible-for-carminic-acid-biosynthesis-in-dactylopius-coccus-costa
#9
Rubini Kannangara, Lina Siukstaite, Jonas Borch-Jensen, Bjørn Madsen, Kenneth T Kongstad, Dan Staerk, Mads Bennedsen, Finn T Okkels, Silas A Rasmussen, Thomas O Larsen, Rasmus J N Frandsen, Birger Lindberg Møller
Carminic acid, a glucosylated anthraquinone found in scale insects like Dactylopius coccus, has since ancient times been used as a red colorant in various applications. Here we show that a membrane-bound C-glucosyltransferase, isolated from D. coccus and designated DcUGT2, catalyzes the glucosylation of flavokermesic acid and kermesic acid into their respective C-glucosides dcII and carminic acid. DcUGT2 is predicted to be a type I integral endoplasmic reticulum (ER) membrane protein, containing a cleavable N-terminal signal peptide and a C-terminal transmembrane helix that anchors the protein to the ER, followed by a short cytoplasmic tail...
December 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/29213079/human-cd26high-t-cells-elicit-tumor-immunity-against-multiple-malignancies-via-enhanced-migration-and-persistence
#10
Stefanie R Bailey, Michelle H Nelson, Kinga Majchrzak, Jacob S Bowers, Megan M Wyatt, Aubrey S Smith, Lillian R Neal, Keisuke Shirai, Carmine Carpenito, Carl H June, Michael J Zilliox, Chrystal M Paulos
CD8+ T lymphocytes mediate potent immune responses against tumor, but the role of human CD4+ T cell subsets in cancer immunotherapy remains ill-defined. Herein, we exhibit that CD26 identifies three T helper subsets with distinct immunological properties in both healthy individuals and cancer patients. Although CD26neg T cells possess a regulatory phenotype, CD26int T cells are mainly naive and CD26high T cells appear terminally differentiated and exhausted. Paradoxically, CD26high T cells persist in and regress multiple solid tumors following adoptive cell transfer...
December 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/29212856/tamoxifen-resistance-in-breast-cancer-is-regulated-by-the-ezh2-er%C3%AE-greb1-transcriptional-axis
#11
Yanming Wu, Zhao Zhang, Mauro E Cenciarini, Cecilia J Proietti, Matias F Amasino, Tao Hong, Mei Yang, Yiji Liao, Huai-Chin Chiang, Virginia Kaklamani, Rinath Jeselsohn, Ratna K Vadlamudi, Tim H-M Huang, Rong Li, Carmine De Angelis, Xiaoyong Fu, Patricia V Elizalde, Rachel Schiff, Myles Brown, Kexin Xu
Resistance to cancer treatment can be driven by epigenetic reprogramming of specific transcriptomes in favor of the refractory phenotypes. Here we discover that tamoxifen resistance in breast cancer is driven by a regulatory axis consisting of a master transcription factor, its cofactor and an epigenetic regulator. The oncogenic histone methyltransferase EZH2 conferred tamoxifen resistance by silencing the expression of the estrogen receptor α (ERα) cofactor GREB1. In clinical specimens, induction of DNA methylation of a particular CpG enriched region at the GREB1 promoter negatively correlated with GREB1 levels and cell sensitivity to endocrine agents...
December 6, 2017: Cancer Research
https://www.readbyqxmd.com/read/29210662/response-to-doxorubicin-of-exfoliated-human-buccal-epithelium-cells-comparison-of-three-methods-of-cell-staining-and-calcium-assessment
#12
Yuriy Shckorbatov, Dmitriy Miroshnik, Igor Kovalenko
BACKGROUND: Doxorubicin is an anthracycline antibiotic which inhibits DNA and RNA synthesis intercalating DNA double helix and inducing free radicals. Doxorubicin is used in treatment of cancer diseases. The influence of Doxorubicin on human buccal cell was used as a model for assessment of toxic effects in vitro. OBJECTIVE: We studied the possibility of using the process of heterochromatinization in cell nuclei in toxicological investigations of drugs in vitro...
December 6, 2017: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29206077/radiosurgery-and-stereotactic-radiotherapy-with-cyberknife-system-for-meningioma-treatment
#13
Rossella Di Franco, Valentina Borzillo, Vincenzo Ravo, Sara Falivene, Francesco Jacopo Romano, Matteo Muto, Fabrizio Cammarota, Giuseppe Totaro, Gianluca Ametrano, Sabrina Rossetti, Carla Cavaliere, Carmine D' Aniello, Gelsomina Iovane, Maria Assunta Porricelli, Massimiliano Berretta, Gerardo Botti, Luigi Starace, Enrico La Salvia, Gaetano Facchini, Paolo Muto
Objective The aim of this work was to evaluate the impact of stereotactic radiosurgery/fractionated stereotactic radiotherapy with the Cyberknife system on local disease control, clinical outcome and toxicity in patients with meningioma, according to the site and histological grade of lesion. From January 2013 to April 2017, 52 patients with intracranial meningiomas were treated with the Cyberknife system. Twenty-four patients had undergone previous surgery: 38% gross total resection, 10% subtotal resection; 27 patients underwent no surgery; 22 patients had a recurrence of meningioma...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/29204837/current-technologies-based-on-the-knowledge-of-the-stem-cells-microenvironments
#14
Damia Mawad, Gemma Figtree, Carmine Gentile
The stem cell microenvironment or niche plays a critical role in the regulation of survival, differentiation and behavior of stem cells and their progenies. Recapitulating each aspect of the stem cell niche is therefore essential for their optimal use in in vitro studies and in vivo as future therapeutics in humans. Engineering of optimal conditions for three-dimensional stem cell culture includes multiple transient and dynamic physiological stimuli, such as blood flow and tissue stiffness. Bioprinting and microfluidics technologies, including organs-on-a-chip, are among the most recent approaches utilized to replicate the three-dimensional stem cell niche for human tissue fabrication that allow the integration of multiple levels of tissue complexity, including blood flow...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29204243/erratum-to-inter-device-reproducibility-of-retrobulbar-blood-flow-velocity-measurements-in-healthy-subjects-using-color-doppler-imaging
#15
Alice Chandra Verticchio Vercellin, Carlo A Cutolo, Carolina Dellafiore, Massimiliano Lava, Carmine Tinelli, Annalisa De Silvestri, Fabrizio Calliada, Giovanni Milano
[This corrects the article DOI: 10.1007/s40477-016-0194-5.].
December 2017: Journal of Ultrasound
https://www.readbyqxmd.com/read/29203627/favorable-vascular-actions-of-angiotensin-1-7-in-human-obesity
#16
Francesca Schinzari, Manfredi Tesauro, Augusto Veneziani, Nadia Mores, Nicola Di Daniele, Carmine Cardillo
Obese patients have vascular dysfunction related to impaired insulin-stimulated vasodilation and increased endothelin-1-mediated vasoconstriction. In contrast to the harmful vascular actions of angiotensin (Ang) II, the angiotensin-converting enzyme 2 product Ang-(1-7) has shown to exert cardiovascular and metabolic benefits in experimental models through stimulation of the Mas receptor. We, therefore, examined the effects of exogenous Ang-(1-7) on vasodilator tone and endothelin-1-dependent vasoconstriction in obese patients...
December 4, 2017: Hypertension
https://www.readbyqxmd.com/read/29195216/photo-induced-toxicity-of-tungsten-oxide-photochromic-nanoparticles
#17
A L Popov, N M Zholobak, O I Balko, O B Balko, A B Shcherbakov, N R Popova, O S Ivanova, A E Baranchikov, V K Ivanov
We synthesised a new type of photochromic tungsten oxide nanoparticles, analysed their photocatalytic activity and carried out a thorough analysis of their effect on prokaryotic and eukaryotic organisms. Ultrasmall hydrated tungsten oxide nanoparticles were prepared by means of hydrothermal treatment of tungstic acid in the presence of polyvinylpyrrolidone as a template, stabiliser and growth regulator. Tungstic acid was synthesised through an ion-exchange method using sodium tungstate solution and a strongly acidic cation exchange resin...
November 20, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29192656/integrating-omics-approaches-to-prioritize-new-pathogenetic-mechanisms-for-mental-disorders
#18
Annamaria Cattaneo, Carmine M Pariante
No abstract text is available yet for this article.
January 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29189829/-oral-combination-therapy-for-the-treatment-of-patients-with-pulmonary-arterial-hypertension-what-evidence-from-long-term-studies
#19
Beatrice Pezzuto, Roberto Badagliacca, Roberto Poscia, Roberto Torre, Stefano Ghio, Laura Scelsi, Alessandra Greco, Michele D'Alto, Paola Argiento, Patrizio Vitulo, Francesco Fedele, Carmine Dario Vizza
The introduction of specific drugs for the treatment of pulmonary arterial hypertension over the last 20 years has led to an improvement of clinical and hemodynamic conditions and prognosis of affected patients. The use of combination therapy has made it possible to act simultaneously on several biological pathways involved in the etiopathogenesis of the disease. However, although the diagnosis and management have radically changed in recent years, the disease remains progressive and often fatal. The purpose of this paper is to review and discuss the results of the main clinical trials and the future perspectives of combination strategies for the treatment of pulmonary arterial hypertension...
December 2017: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29187471/resectability-and-vascular-management-of-retroperitoneal-gynecological-malignancies-a-large-single-institution-case-series
#20
Giovanni Tinelli, Serena Cappuccio, Ezio Parente, Anna Fagotti, Valerio Gallotta, Carmine Conte, Barbara Costantini, Salvatore Gueli Alletti, Giovanni Scambia, Giuseppe Vizzielli
BACKGROUND/AIM: To report on morbidity and oncological outcomes in a consecutive series of gynecological malignancies involving the vascular district. PATIENTS AND METHODS: We retrospectively evaluated a consecutive series between 1/2015 and 1/2017 with suspicious gynecological malignancies involving the vascular district. Peri-operative data and survival rates were computed. RESULTS: Eight-hundred-four women with gynecological malignancies were admitted for major oncologic surgery during the study period, and among them, 50 cases (6...
December 2017: Anticancer Research
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