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Laura Levaggi, Rosella Levaggi, Carmine Trecroci
We analyse incentives, equilibria and implications of the governance framework for the disposal of municipal solid waste in an N-Region model where waste mobility is allowed. The key decisions revolve around the flow of waste between regions and the externalities associated with its final disposal. Two different institutional settings are considered: a centralised framework where a central planner takes all the decisions and a decentralised model where each region decides on its waste flows. When the regions are characterised by different levels of efficiency in the final treatment of waste, a certain degree of mobility might allow to reap the benefits of higher efficiency...
April 18, 2018: Journal of Environmental Management
Swetlana Gautam, Soniya Rani, Gaurav Kaithwas
The present study was designed to evaluate the effects of Phenidone (Dual inhibitor of COX-2 and 5-LOX, DuCLOX-2/5) on various aspects of cancer chemoprevention against MNU induced mammary gland carcinoma. MNU treated rat showed altered heart rate variability (HRV), increased alveolar bud count, differentiation score, up regulated inflammatory enzyme markers (COX, LOX, NO and H2S) and distorted oxidative stress markers (TBARs, protein carbonyl, SOD, catalase and GSH). The mammary gland surface architecture was studied using carmine staining and H&E staining...
April 18, 2018: Toxicology and Applied Pharmacology
Filomena Napolitano, Francesca Wanda Rossi, Ada Pesapane, Silvia Varricchio, Gennaro Ilardi, Massimo Mascolo, Stefania Staibano, Antonio Lavecchia, Pia Ragno, Carmine Selleri, Gianni Marone, Marco Matucci-Cerinic, Amato de Paulis, Nunzia Montuori
Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by fibrosis, alteration in the microvasculature and immunologic abnormalities. It has been hypothesized that an abnormal redox state could regulate the persistent fibrotic phenotype in SSc patients. N -Formyl peptide receptors (FPRs) are chemotactic receptors overexpressed in fibroblasts derived from SSc patients. In this study, we demonstrated that stimulation of FPRs promotes the generation of reactive oxygen species (ROS) in skin fibroblasts...
2018: Frontiers in Immunology
Graziella D'arrigo, Patrizia Pizzini, Sebastiano Cutrupi, Rocco Tripepi, Giovanni Tripepi, Francesca Mallamaci, Carmine Zoccali
Background: Thrombomodulin (TM) is a proteoglycan highly represented in the endothelial glycocalix that regulates the haemostasis and the endothelial response to inflammation. High soluble TM levels underlie a lower risk for coronary heart disease in population studies. Activation of vitamin D receptor (VDR) upregulates TM, but the effect of this intervention on soluble TM has never been tested in chronic kidney disease (CKD) patients. Methods: We performed a post hoc analysis of a 12 weeks double blind, randomized, placebo-controlled trial testing the effect of VDR activation by paricalcitol (PCT) on endothelium-dependent flow-mediated vasodilatation (FMD) in the forearm (ClinicalTrials...
April 13, 2018: Nephrology, Dialysis, Transplantation
Ann D Flynn, John F Valentine
Long-standing ulcerative colitis (UC) and extensive Crohn's colitis confer increased risk for development of colorectal cancer. Screening and surveillance colonoscopy programs aim to identify, resect, or detect dysplasia or colorectal cancer. Dysplastic lesions can be removed by endoscopic resection and patients with unresectable lesions can be referred for colectomy at an earlier stage, with the goal of reducing overall morbidity and mortality from colorectal cancer. Surveillance colonoscopy for patients with inflammatory bowel disease (IBD) is endorsed by multiple specialty societies...
April 13, 2018: Inflammatory Bowel Diseases
Debra L Irsik, Melissa Jill Romero-Aleshire, Erin M Chavez, Rachel W Fallet, Heddwen L Brooks, Pamela K Carmines, Pascale H Lane
Estrogen has been implicated in the regulation of growth and immune function in the kidney, which expresses the full-length estrogen receptor α (ERα66), its ERα splice variants, and estrogen receptor β (ERβ). Thus, we hypothesized that these splice variants may inhibit glomerular enlargement that occurs early in type 1 diabetes (T1D). T1D was induced by streptozotocin (STZ) injection in 8-12 wk-old female mice lacking ERα66 (ERα66KO) or all ERα variants (αERKO), and their wild-type (WT) littermates...
April 18, 2018: American Journal of Physiology. Renal Physiology
Margherita De Rosa, Pellegrino La Manna, Carmen Talotta, Annunziata Soriente, Carmine Gaeta, Placido Neri
In the last decades many efforts have been devoted to design supramolecular organocatalysts able to work in water as the reaction medium. The use of water as solvent provides promising benefits with respect to environmental impact. In this context, macrocyclic compounds played a role of primary importance thanks to their ease of synthesis and their molecular recognition abilities toward the reactants. The aim of this review is to give an overview of the recent advances in the field of supramolecular organocatalysis in water, focusing the attention on calixarene and cyclodextrins derivatives...
2018: Frontiers in Chemistry
Shusaku Matsumura, Aya Matsusue, Brian Waters, Masayuki Kashiwagi, Kenji Hara, Shin-Ichi Kubo
Detection of body fluid-specific mRNAs, such as those specific for blood, using real-time polymerase chain reaction (PCR) has become a useful tool in forensic science. Blood stains often contain PCR inhibitors that may be co-extracted with RNA and adversely affect PCR. The effects of inhibitors on the detection of mRNA markers for blood identification, namely, hemoglobin beta (HBB) and actin beta, were examined herein. Inhibitors were added to a real-time PCR mix, reverse transcription mix, and blood samples before RNA extraction, and the following parameters: Ct, delta Ct (dCt), and melting temperature (Tm) values, were monitored...
April 9, 2018: Legal Medicine
Madan Kumar, Arti Mishra, Shashi Shekhar Singh, Shaili Srivastava, Indu Shekhar Thakur
In the present study, a non-blue laccase gene from previously reported lignin degrading bacterium, Pandoraea sp. ISTKB, was isolated, cloned and expressed in E. coli. Bioinformatics analysis of sequence discovered twin-arginine translocation signal sequence, copper binding motifs and presence of more random coil compare to helices and sheets in structure. The enzyme was found to be active on wide pH range and the pH optima was observed at pH 4 and 8 on substrate 2,2'-Azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) and 2,6-Dimethoxyphenol respectively...
April 14, 2018: International Journal of Biological Macromolecules
Katharina Brück, Kitty J Jager, Carmine Zoccali, Aminu K Bello, Roberto Minutolo, Kyriakos Ioannou, Francis Verbeke, Henry Völzke, Johan Arnlöv, Daniela Leonardis, Pietro Manuel Ferraro, Hermann Brenner, Ben Caplin, Philip A Kalra, Christoph Wanner, Alberto Martinez Castelao, Jose Luis Gorriz, Stein Hallan, Dietrich Rothenbacher, Dino Gibertoni, Luca De Nicola, Georg Heinze, Wim Van Biesen, Vianda S Stel
The incidence of renal replacement therapy varies across countries. However, little is known about the epidemiology of chronic kidney disease (CKD) outcomes. Here we describe progression and mortality risk of patients with CKD but not on renal replacement therapy at outpatient nephrology clinics across Europe using individual data from nine CKD cohorts participating in the European CKD Burden Consortium. A joint model assessed the mean change in estimated glomerular filtration rate (eGFR) and mortality risk simultaneously, thereby accounting for mortality risk when estimating eGFR decline and vice versa, while also correcting for the measurement error in eGFR...
April 12, 2018: Kidney International
Maria Ricciardi, Fabrizio Passarini, Carmine Capacchione, Antonio Proto, Joel Barrault, Raffaele Cucciniello, Daniele Cespi
The selective preparation of monoalkylglyceryl ethers (MAGEs) is an active task of research due to their broad range of applications. In this work, green feedstocks such as glycidol and alcohols were used to prepare MAGEs under mild reaction conditions (80°C, 3h, 0.5% in moles of catalyst) in the presence of acid heterogeneous catalysts. Nafion shows the best performances in terms of conversion and selectivity to MAGES and also high stability. A comparison of the environmental performances with the most consolidated pathway from glycerol has shown that the usage of glycidol (recovered as value-added product from Epicerol® process) and Nafion leads to lower impacts on ecosystems...
April 14, 2018: ChemSusChem
Barbara Gardella, Mattia Dominoni, Anna Daniela Iacobone, Annalisa De Silvestri, Carmine Tinelli, Stefano Bogliolo, Arsenio Spinillo
BACKGROUND: This work analyzes the feasibility and effectiveness of barbed suture during laparoscopic myomectomy. METHODS: Eight works have been carefully examined for the meta-analysis from all papers published online until November 2017. RESULTS: Barbed suture proved to be superior to traditional suture technique in blood loss in laparoscopic myomectomy (Standardized Mean Difference [SMD] -0.650, 95% CI -1.420 to -0.119, p = 0.098, test for heterogenity p < 0...
April 12, 2018: Gynecologic and Obstetric Investigation
Carmelo Puglia, Paolo Blasi, Carmine Ostacolo, Eduardo Sommella, Claudio Bucolo, Chiara B M Platania, Giovanni L Romano, Federica Geraci, Filippo Drago, Debora Santonocito, Barbara Albertini, Pietro Campiglia, Giovanni Puglisi, Rosario Pignatello
Nanostructured lipid carriers (NLCs) loaded with palmitoylethanolamide (PEA) were formulated with the aim to enhance ocular bioavailability of PEA, particularly to the back of the eye. Technological characterization (e.g., size, charge) of NLC loaded with PEA formulation (PEA-NLC) was performed, and NLC morphology was characterized by electron microscopy. Ocular pharmacokinetic study, after topical administration of the formulation, was carried out in rabbit eye. Ultra-high performance liquid chromatography tandem mass spectrometry analysis was carried out to detect PEA levels in ocular tissues...
2018: Frontiers in Pharmacology
Xichuan Zhai, Dehui Lin, Yan Zhao, Xingbin Yang
This study was to probe the effects of bacterial cellulose (BC) on diphenoxylate-induced constipation in rats. Administration with BC at 500 mg/kg·bw in diphenoxylate-induced constipation rats distinctly improved the carmine propulsion rate (83.5 ± 5.2%), shortened the defecating time of the first red feces (249.0 ± 23.3 min), and increased the weight of carmine red feces within 5 h (2.7 ± 1.3 g). The levels of aquaporins (AQP-2, AQP-3 and AQP-4) and inhibitory neurotransmitters (nitric oxide, nitric oxide synthetase, vasoactive intestinal peptide and arginine vasopressin) in the BC-treated groups reduced by 31...
April 7, 2018: Journal of Agricultural and Food Chemistry
Gabriele Giacomo Schiattarella, Albino Carrizzo, Federica Ilardi, Antonio Damato, Mariateresa Ambrosio, Michele Madonna, Valentina Trimarco, Marina Marino, Elena De Angelis, Silvio Settembrini, Cinzia Perrino, Bruno Trimarco, Giovanni Esposito, Carmine Vecchione
BACKGROUND: Vascular complications and abnormal platelet function contribute to morbidity and mortality in diabetes mellitus. We hypothesized that the Rho-related GTPase protein, Rac1, can influence both endothelial and platelet function and might represent a potential novel therapeutic target in diabetes mellitus. METHODS AND RESULTS: We used both in vitro and ex vivo approaches to test the effects of pharmacological inhibition of Rac1 during hyperglycemic condition...
April 6, 2018: Journal of the American Heart Association
Nicola Gaibazzi, Carmine Mazzone, Pompilio Faggiano
No abstract text is available yet for this article.
June 1, 2018: International Journal of Cardiology
Giuseppe Cannalire, Luigi Conti, Maurizio Celoni, Carmine Grassi, Andrea Cella, Giulia Bensi, Patrizio Capelli, Giacomo Biasucci
BACKGROUND: Iron deficiency anemia (IDA) and abdominal pain are commonly seen in a pediatric emergency department (8 and 18% incidence respectively in our center). They are manifestations of a wide variety of diseases ranging from benign to immediately life-threatening. Trichobezoar is an under-diagnosed entity that has to be considered in children and adolescents, expecially female, suffering from trichotillomania (compulsion to pull hair) and trichophagy (compulsion to swallow hair)...
April 4, 2018: BMC Pediatrics
Margaret Salmon, Christian Salmon, Maurice Masoda, Jean-Maurice Salumu, Carmine Bozzi, Phil Nieburg, Lisa M Harrison, Debbie Humphries, Naomi Abaca Uvon, Sarah K Wendel, Clint Trout, Michael Cappello
An estimated 4.7 billion people live in regions exposed to soil-transmitted helminths, intestinal parasites that have significant impacts on the health of women smallholder farmers. The goal of this trial was to determine whether treatment with albendazole impacts the work capacity of these farmers. This is a prospective double-blind, randomized effectiveness trial. Participants ( N = 250) were randomly selected from safe motherhood groups in the Democratic Republic of Congo. Prevalence/intensity of hookworm infection, hemoglobin, and demographics was obtained...
April 2, 2018: American Journal of Tropical Medicine and Hygiene
Tomohiro Kagawa, Naoyuki Endo, Goro Ebisu, Ippei Yamaoka
This study has the following aims: (1) to confirm a methodology for a fecal indocyanine green (ICG) imaging test for measuring gastro-intestinal transit time (GITT); and (2) to compare GITT in mice given a liquid diet in which viscosity increases under acidic conditions to that in mice given stable liquid diets with comparable viscosity or regular chow. To address Aim 1, mice received ICG orally along with intraperitoneal injection of atropine in Study 1, and mice were given ICG orally with concurrent carmine red for Study 2...
April 2018: Physiological Reports
Veronica Ojetti, Carmine Petruzziello, Silvia Cardone, Luisa Saviano, Alessio Migneco, Luca Santarelli, Maurizio Gabrielli, Raffaella Zaccaria, Loris Lopetuso, Marcello Covino, Marcello Candelli, Antonio Gasbarrini, Francesco Franceschi
BACKGROUND & AIMS: Diverticular Disease (DD) is a common clinical condition with a dramatic increasing of the prevalence among industrialized countries. Based on the most used classification, DD may be divided into asymptomatic diverticulosis, symptomatic uncomplicated diverticular disease and complicated diverticular disease. Since recent studies pointed out the role of GUT microbiota imbalance in promoting diverticular formation and inflammation, we have designed a systematic review focusing on the possible role of probiotics in the management of this condition...
April 2, 2018: Reviews on Recent Clinical Trials
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