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Joline Tung, Lih Shin Tew, Carmine Coluccini, Yue-Der Lin, Yit Lung Khung
Here, we described the outcome of thermal grafting of 2-ethynylaniline, 3-ethynylaniline and 4-ethynylaniline respectively on hydrogenated Si(100) surface. Using high resolution X-ray photoelectron spectroscopy (XPS) and atomic force microscopy (AFM), it was found that the grafting of these compounds could be attributed to resonating structures that arises from the position of electron donating NH2 and the electron withdrawing acetylene group. For the ortho- and para-positioned acetylene group, surface reactions were observed to proceed predominantly via the acetylene to form a Si-C bond while the meta-positioned acetylene group was found to have undergone nucleophilic grafting through the NH2 onto the silicon surface to form Si-N bond...
June 22, 2018: Chemistry: a European Journal
Melanie Göth, Felix Witte, Marcel Quennet, Phillip Jungk, Gabriel Podolan, Dieter Lentz, Waldemar Hoffmann, Kevin Pagel, Hans-Ulrich Reissig, Beate Paulus, Christoph A Schalley
A series of fluorinated pyridines is investigated by ESI (tandem) mass spectrometry and quantum chemical calculations with respect to their capability to bind anions in the gas phase. The pyridines differ in valency, the degree of fluorination, the positions of the fluorine atoms, the rigidity of the spacers and the relative configuration. While the monovalent compounds did not form anion complexes, the divalent analogues exhibit anion binding even to weakly coordinating anions such as tetrafluoroborate. Three different tandem MS experiments were applied to rank the gas-phase binding energies: (i) CID experiments in an FTICR mass spectrometer, (ii) determination of the collision energy required to fragment 50 % of the mass-selected complexes, and (iii) CID of heterodimers formed from two different, competing pyridine receptors and indigo carmine, a dianion with two identical binding sites...
June 20, 2018: Chemistry: a European Journal
Chandler W Rundle, Sharon E Jacob, Brian C Machler
: Carmine is a widely used "natural" food additive that has been reported to provoke both an immediate hypersensitivity and a delayed systemic response with cutaneous expression. Systemic contact dermatitis describes the hypersensitivity reaction following systemic re-exposure of the inciting allergen in previously sensitized individuals. In individuals with recalcitrant dermatitis and a positive carmine intolerance history and/or patch test, it is important to consider a trial topical and dietary elimination of carmine-associated products and foods...
June 19, 2018: Dermatitis
Neil Robinson, Christopher Robertson, Lynn F Gladden, Stephen J Jenkins, Carmine D'Agostino
The ratio of NMR relaxation time constants T1/T2 provides a non-destructive indication of the relative surface affinities exhibited by adsorbates within liquid-saturated mesoporous catalysts. In the present work we provide supporting evidence for the existence of a quantitative relationship between such measurements and adsorption energetics. As a prototypical example with relevance to green chemical processes we examine and contrast the relaxation characteristics of primary alcohols and cyclohexane within an industrial silica catalyst support...
June 20, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
Fabio Mangiacapra, Edoardo Bressi, Alessandro Sticchi, Carmine Morisco, Emanuele Barbato
The presence and extent of myocardial ischemia are the major determinants of prognosis in patients with coronary artery disease (CAD). Unlike coronary angiography alone, fractional flow reserve (FFR) has enabled interventional cardiologists to accurately determine whether coronary atherosclerotic plaques are responsible for myocardial ischemia, and therefore deserve to be revascularized. Areas covered: An overview on the role of FFR in the diagnosis and treatment of coronary artery disease, as well as the potential related controversies is provided...
June 20, 2018: Expert Review of Cardiovascular Therapy
Guido Grassi, Anna Pisano, Davide Bolignano, Gino Seravalle, Graziella D'Arrigo, Fosca Quarti-Trevano, Francesca Mallamaci, Carmine Zoccali, Giuseppe Mancia
Muscle sympathetic nerve activity (MSNA) has shown that sympathetic activation may occur in essential hypertension (EHT). However, the small sample size of the studies, the heterogeneity of the patients examined, and the presence of confounders represented major weaknesses not allowing to draw definite conclusions. Among the 432 studies identified providing information in EHT on MSNA, 63 were eligible (1216 patients) and meta-analyzed grouping them on the basis of clinically relevant questions: (1) Is MSNA increased in hypertension of mild/moderate-to-severe degree? (2) Does sympathetic activation occur in borderline, white-coat, and masked EHT? (3) Is MSNA related to clinic and ambulatory blood pressure and target organ damage? (4) Are heart rate and venous plasma norepinephrine valuable surrogate markers of MSNA in clinical practice? The results show that MSNA was significantly greater (1...
June 18, 2018: Hypertension
Federica Laudisi, Fabio Cherubini, Giovanni Monteleone, Carmine Stolfi
Signal transducers and activators of transcription (STATs) mediate essential signaling pathways in different biological processes, including immune responses, hematopoiesis, and neurogenesis. Among the STAT members, STAT3 plays crucial roles in cell proliferation, survival, and differentiation. While STAT3 activation is transient in physiological conditions, STAT3 becomes persistently activated in a high percentage of solid and hematopoietic malignancies (e.g., melanoma, multiple myeloma, breast, prostate, ovarian, and colon cancers), thus contributing to malignant transformation and progression...
June 16, 2018: International Journal of Molecular Sciences
Charles L Raison, Jennifer M Knight, Carmine Pariante
No abstract text is available yet for this article.
June 14, 2018: Brain, Behavior, and Immunity
Maryam Shamsayei, Yadollah Yamini, Hamid Asiabi
In this work, the bio-nanohybrids of magnesium-aluminum layered double hydroxide intercalated with zwitterionic histidine (His-LDH) was synthesized. The crystal phase, morphology, and nanostructure of the as-prepared His-LDH were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), and nitrogen adsorption-desorption methods. The His-LDHs were used to remove anionic dyes, including Congo red (CR), indigo carmine (IC) and sunset yellow FCF (SY) from aqueous solutions...
June 13, 2018: Journal of Colloid and Interface Science
Doaa M Mokhtar
Fish liver is considered as a key organ that controls various life functions. The cellular and stromal elements of liver of eighteen specimens of adult grass carp were investigated by light- and electron- microscopy and enzyme histochemistry. The liver was formed of two lobes with a long process extended from the right lobe. Serial paraffin section of the liver identified different kinds of vascular- biliary structures as follows: 1) pancreatic-venous-biliary-arteriolar tracts (P-VBAT); 2) venous-biliary-arteriolar tracts, (VBAT); 3) pancreatic-venous-biliary tracts (P-VBT); 4) venous-biliary tracts (VBT); 5) venous-arteriolar tracts (VAT); 6) isolated veins named as venous tracts (VT); 7) isolated bile ducts, named as biliary tracts (BT); 8) biliary-arteriolar tracts (BAT); 9) pancreatic-biliary tracts (P-BT); 10) pancreatic- venous tracts (P-VT)...
June 6, 2018: Micron: the International Research and Review Journal for Microscopy
Alessandro Moro, Paolo De Angelis, Sandro Pelo, Giulio Gasparini, Giuseppe D'Amato, Pier Carmine Passarelli, Gianmarco Saponaro
The purpose of this study was to evaluate the clinical and radiological outcomes of 2 piezosurgical split techniques performed in conjunction with the sinus lift.The present retrospective study included 20 patients with edentulism of the posterior maxilla who had undergone the sinus lift and alveolar ridge split treatment separately or the sinus lift combined with the monoblock alveolar ridge split. Differences between these 2 techniques were analyzed.All the surrounding areas successfully produced an adequate bone volume for the insertion of implants...
June 2018: Medicine (Baltimore)
Loreta A Kondili, Sarah Robbins, Sarah Blach, Ivane Gamkrelidze, Anna Linda Zignego, Maurizia Rossana Brunetto, Giovanni Raimondo, Gloria Taliani, Andrea Iannone, Francesco Paolo Russo, Teresa Antonia Santantonio, Massimo Zuin, Luchino Chessa, Pierluigi Blanc, Massimo Puoti, Maria Vinci, Elke Maria Erne, Mario Strazzabosco, Marco Massari, Pietro Lampertico, Maria Grazia Rumi, Alessandro Federico, Alessandra Orlandini, Alessia Ciancio, Guglielmo Borgia, Pietro Andreone, Nicola Caporaso, Marcello Persico, Donatella Ieluzzi, Salvatore Madonia, Andrea Gori, Antonio Gasbarrini, Carmine Coppola, Giuseppina Brancaccio, Angelo Andriulli, Maria Giovanna Quaranta, Simona Montilla, Homie Razavi, Mario Melazzini, Stefano Vella, Antonio Craxì
BACKGROUND & AIMS: Advances in direct acting anti-viral treatment of HCV have reinvigorated public health initiatives aimed at identifying affected individuals. We evaluated the possible impact of only diagnosed and linked-to-care individuals on overall HCV burden estimates and identified a possible strategy to achieve the WHO targets by 2030. METHODS: Using a modelling approach grounded in Italian real-life data of diagnosed and treated patients, different linkage-to-care scenarios were built to evaluate potential strategies in achieving the HCV elimination goals...
June 14, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
Andrea Castellucci, Cristina Brandolini, Valeria Del Vecchio, Davide Giordano, Carmine Pernice, Giovanni Bianchin, Vincenzo Maiolo, Gian Gaetano Ferri
No abstract text is available yet for this article.
July 2018: Otology & Neurotology
Antonella Pasqualone, Carmine Summo, Barbara Laddomada, Elena Mudura, Teodora Emilia Coldea
Borş is a traditional Romanian beverage obtained by naturally fermenting an aqueous suspension of wheat bran and corn flour, used as flavoring enhancer in local gastronomy since ancient times, and more recently consumed as refreshing drink. To investigate the changes in sensory, physico-chemical, phenolic and aroma composition resulted after two successive fermentations, borș samples were subjected to standard, sensory, HPLC and GC/MS analysis. Total phenolic compounds and ferulic acid, the most abundant phenolic compound, were positively influenced by natural starter addition, increase of fermentation temperature, and thermal treatment, whereas the effect on less abundant phenolic acids was not univocal...
November 1, 2018: Food Chemistry
Valeria Romeo, Carlo Cavaliere, Carmine Sorrentino, Andrea Ponsiglione, Lorenzo Ugga, Luigi Barbuto, Francesco Verde, Mario Covello
Aim of this study is to assess the clinical impact of coronal short tau inversion recovery (STIR)-weighted magnetic resonance (MR) sequence, when acquired in a lumbar spine MR imaging protocol, in detecting significant extraspinal imaging findings in patients with low back pain (LBP).We retrospectively evaluated 931 lumbar spine MR examinations of patients with LBP. Extraspinal MR imaging findings were categorized as: probably related to LBP (Category 1), not related to LBP but with relevant implications on patient's care (Category 2), and not related to LBP without significant implications on patient's care (Category 3)...
June 2018: Medicine (Baltimore)
Carmine Settembre, Laura Cinque, Rosa Bartolomeo, Chiara Di Malta, Chiara De Leonibus, Alison Forrester
The lysosome is a catabolic organelle devoted to the degradation of cellular components, such as protein complexes and whole or portion of organelles that reach the lysosomes through (macro)autophagy. The lysosomes also function as signaling organelles by controlling the activity of key metabolic kinases, such as the mechanistic target of Rapamycin complex 1 (mTORC1). Lysosome dysfunction has dramatic consequences on cellular homeostasis and cause lysosomal storage disorders (LSDs). Here we review the recently proposed mechanisms by which impairment of lysosome/autophagy pathway affects extracellular matrix formation and skeletal development and growth...
June 2, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
Carmine Rocca, Saveria Femminò, Giorgio Aquila, Maria C Granieri, Ernestina M De Francesco, Teresa Pasqua, Damiano C Rigiracciolo, Francesca Fortini, Maria C Cerra, Marcello Maggiolini, Pasquale Pagliaro, Paola Rizzo, Tommaso Angelone, Claudia Penna
G protein-coupled estrogen receptor (GPER) is an estrogen receptor expressed in the cardiovascular system. G1, a selective GPER ligand, exerts cardiovascular effects through activation of the PI3K-Akt pathway and Notch signaling in normotensive animals. Here, we investigated whether the G1/GPER interaction is involved in the limitation of infarct size, and improvement of post-ischemic contractile function in female spontaneous hypertensive rat (SHR) hearts. In this model, we also studied Notch signaling and key components of survival pathway, namely PI3K-Akt, nitric oxide synthase (NOS) and mitochondrial K+ -ATP (MitoKATP) channels...
2018: Frontiers in Physiology
Michele Massimo Gulizia, Furio Colivicchi, Maurizio Giuseppe Abrignani, Marco Ambrosetti, Nadia Aspromonte, Gabriella Barile, Roberto Caporale, Giancarlo Casolo, Emilia Chiuini, Andrea Di Lenarda, Pompilio Faggiano, Domenico Gabrielli, Giovanna Geraci, Alessio Gaetano La Manna, Aldo Pietro Maggioni, Alfredo Marchese, Ferdinando Maria Massari, Gian Francesco Mureddu, Giuseppe Musumeci, Federico Nardi, Antonio Vittorio Panno, Roberto Franco Enrico Pedretti, Massimo Piredda, Enrico Pusineri, Carmine Riccio, Roberta Rossini, Fortunato Scotto di Uccio, Stefano Urbinati, Ferdinando Varbella, Giovanni Battista Zito, Leonardo De Luca
Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 receptor inhibitor is the cornerstone of pharmacologic management of patients with acute coronary syndrome (ACS) and/or those receiving coronary stents. Long-term (>1 year) DAPT may further reduce the risk of stent thrombosis after a percutaneous coronary intervention (PCI) and may decrease the occurrence of non-stent-related ischaemic events in patients with ACS. Nevertheless, compared with aspirin alone, extended use of aspirin plus a P2Y12 receptor inhibitor may increase the risk of bleeding events that have been strongly linked to adverse outcomes including recurrent ischaemia, repeat hospitalisation and death...
May 2018: European Heart Journal Supplements: Journal of the European Society of Cardiology
Yiwen Li, Carmine Carpenito, George Wang, David Surguladze, Amelie Forest, Maria Malabunga, Mary Murphy, Yiwei Zhang, Andreas Sonyi, Darin Chin, Douglas Burtrum, Ivan Inigo, Anthony Pennello, Leyi Shen, Laurent Malherbe, Xinlei Chen, Gerald Hall, Jaafar N Haidar, Dale L Ludwig, Ruslan D Novosiadly, Michael Kalos
Unfortunately, after publication of this article [1], it was noticed that corrections to the legends of Figs. 1 and 2 were not correctly incorporated. The correct legends can be seen below.
June 4, 2018: Journal for Immunotherapy of Cancer
Valeria Conti, Graziamaria Corbi, Valentina Manzo, Paola Malangone, Carolina Vitale, Angelantonio Maglio, Roberta Cotugno, Damiano Capaccio, Luigi Marino, Carmine Selleri, Cristiana Stellato, Amelia Filippelli, Alessandro Vatrella
Background: Oxidative stress is a recognized pathogenic mechanism in chronic obstructive pulmonary disease (COPD). Expression of the NAD+ -dependent deacetylase Sirtuin 1 (SIRT1), an antiaging molecule with a key role in oxidative stress response, has been described as decreased in the lung of COPD patients. No studies so far investigated whether systemic SIRT1 activity was associated to decreased lung function in this disease. Methods: We measured SIRT1 protein expression and activity in peripheral blood mononuclear cells (PBMCs) and total oxidative status (TOS), total antioxidant capacity (TEAC), and oxidative stress index (TOS/TEAC) in the plasma of 25 COPD patients, 20 healthy nonsmokers (HnS), and 20 healthy smokers (HS)...
2018: Oxidative Medicine and Cellular Longevity
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