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https://www.readbyqxmd.com/read/28818609/multicenter-comparison-of-22c3-pharmdx-agilent-and-sp263-ventana-assays-to-test-pd-l1-expression-for-nsclc-patients-to-be-treated-with-immune-checkpoint-inhibitors
#1
Antonio Marchetti, Massimo Barberis, Renato Franco, Graziano De Luca, Maria Vittoria Pace, Stefania Staibano, Marco Volante, Fiamma Buttitta, Elena Guerini-Rocco, Luisella Righi, Tommaso D'antuono, Giorgio V Scagliotti, Carmine Pinto, Gaetano De Rosa, Mauro Papotti
INTRODUCTION: Among the several agents targeting the programmed cell death 1 (PD-1) pathway, pembrolizumab is currently the only one approved for the treatment of non-small cell lung cancer patients in association with a companion diagnostic assay, the anti-programmed cell death ligand 1 (PD-L1) immunohistochemical (IHC) 22C3 PharmDx (Agilent) using the Dako Autostainer. However, the Dako platform is not present in each pathology department and this technical limitation is a major problem for the diffusion of the PD-L1 IHC predictive test for pembrolizumab...
August 14, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28816376/acetic-acid-indigo-carmine-mixture-for-evaluating-the-margins-of-sessile-serrated-adenomas-polyps
#2
Shunsuke Yamamoto, Morteza Shafazand
Sessile serrated adenomas/polyps (SSA/Ps) have attracted increasing attention since their risk of developing into cancer was clarified [1]. Difficulty in determining their margins causes incomplete resection [2]. Although narrow-band imaging (NBI) and other advanced imaging systems are reportedly useful in evaluating these polyps [3, 4]. This article is protected by copyright. All rights reserved.
August 17, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28814259/may-gender-or-ethnicity-affect-delta-over-baseline-values-obtained-by-13-c-urea-breath-test
#3
Carmine Petruzziello, Dario Sinatti, Maria Gnarra, Alessio Migneco, Valentina Tesori, Cristina Graziani, Antonio Gasbarrini, Francesco Franceschi, Veronica Ojetti
INTRODUCTION: 13C-urea breath test (UBT) is a non-invasive test for detecting active H.pylori infection. Previous studies showed a correlation of delta over baseline (DOB) values with bacterial load, mucosal inflammation and successful eradication. Gender has been shown to affect DOB in children. Aim of our study was to verify whether gender or ethnicity affects DOB in adults. PATIENTS AND METHODS: We retrospectively analyzed data of 2922 patients (1024M/1898F mean age 47±15 years) that underwent UBT in our outpatient unit, from October 2015 to October 2016...
August 16, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/28812917/predictive-role-of-cha2ds2-vasc-score-for-cardiovascular-events-and-death-in-patients-with-arterial-hypertension-and-stable-sinus-rhythm
#4
Carmine Mazzone, Giovanni Cioffi, Cosimo Carriere, Giulia Barbati, Giorgio Faganello, Giulia Russo, Antonella Cherubini, Gianfranco Sinagra, Nadia Zeriali, Andrea Di Lenarda
Background The CHA2DS2-VASc score well stratifies the risk for thromboembolic events in non-valvular atrial fibrillation (NVAF) patients. This score may also predict thromboembolic events in sinus rhythm populations. Purpose The purpose of this study was to assess the prognostic role of CHA2DS2-VASc in a Caucasian community population of patients with arterial hypertension and sinus rhythm. Methods A total of 12,599 arterial hypertension residents not receiving anticoagulation were selected from a community population in Trieste between November 2009 and October 2014: 11,159 sinus rhythm and 1440 NVAF patients...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28810724/sympathetic-nerve-traffic-and-blood-pressure-changes-after-bilateral-renal-denervation-in-resistant-hypertension-a-time-integrated-analysis
#5
Gino Seravalle, Graziella D'Arrigo, Giovanni Tripepi, Francesca Mallamaci, Gianmaria Brambilla, Giuseppe Mancia, Guido Grassi, Carmine Zoccali
Background: Renal denervation reduces blood pressure (BP) and sympathetic drive in experimental animal models, but the effect of this intervention on sympathetic activity in patients with treatment-resistant hypertension is still unclear. Methods: In an incident series of 29 patients with treatment-resistant hypertension, we performed serial measurements (n = 123) of muscle sympathetic nerve activity (MSNA, microneurography) and standardized BP measurements. Data were analysed by mixed linear modelling (MLM) and by regression analysis of time-integrated changes of both MSNA and synchronous, standardized (in-lab) BP measurements...
August 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28810222/bio-electro-oxidation-of-indigo-carmine-by-using-microporous-activated-carbon-fiber-felt-as-anode-and-bioreactor-support
#6
Luane Ferreira Garcia, Ana Claudia Rodrigues Siqueira, Germán Sanz Lobón, Jossano Saldanha Marcuzzo, Benevides Costa Pessela, Eduardo Mendez, Telma Alves Garcia, Eric de Souza Gil
The bioremediation and electro-oxidation (EO) processes are included among the most promising cleaning and decontamination mechanisms of water. The efficiency of bioremediation is dictated by the biological actuator for a specific substrate, its suitable immobilization and all involved biochemical concepts. The EO performance is defined by the anode efficiency to perform the complete mineralization of target compounds and is highlighted by the low or null use of reagent. Recently, the combination of both technologies has been proposed...
August 10, 2017: Chemosphere
https://www.readbyqxmd.com/read/28809841/measuring-neuromuscular-junction-functionality
#7
Emanuele Rizzuto, Simona Pisu, Carmine Nicoletti, Zaccaria Del Prete, Antonio Musarò
Neuromuscular junction (NMJ) functionality plays a pivotal role when studying diseases in which the communication between motor neuron and muscle is impaired, such as aging and amyotrophic lateral sclerosis (ALS). Here we describe an experimental protocol that can be used to measure NMJ functionality by combining two types of electrical stimulation: direct muscle membrane stimulation and the stimulation through the nerve. The comparison of the muscle response to these two different stimulations can help to define, at the functional level, potential alterations in the NMJ that lead to functional decline in muscle...
August 6, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28807777/bilateral-temporal-myofascial-flap-for-the-reconstruction-of-frontal-sinus-defects
#8
Filippo Gagliardi, Michele Bailo, Alfio Spina, Nicola Boari, Carmine A Donofrio, Martina Piloni, Cristian Gragnaniello, Anthony J Caputy, Pietro Mortini
BACKGROUND: A frontal sinus infection, following a trans-sinus skull base procedure, portends potentially life-threatening complications, making surgical revision mandatory in refractory infections. The authors describe the application of the bilateral temporal myofascial flap (BTMF) as a valuable option for frontal sinus reconstruction, when pericranial or galeal-frontalis myofascial flap (GFMF) is no longer available. METHODS: A microanatomical laboratory investigation on cadaver was conducted to obtain anthropometric measurements...
August 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28805382/tuning-cycloparaphenylene-host-properties-by-chemical-modification
#9
Paolo Della Sala, Carmen Talotta, Tonino Caruso, Margherita De Rosa, Annunziata Soriente, Placido Neri, Carmine Gaeta
[8]Cycloparaphenylene derivative 1 has been synthesized and its recognition abilities toward pyridinium guests have been investigated and compared with the [8]CPP macrocycle. The results showed a fine tuning of the binding properties of [8]CPP 1 toward pyridinium cations due to the presence of 1,4-DMB ring. DFT calculations indicate that the close steric fitting between the rigid cavity of 1 and the pyridinium guest is the crucial factor for the stabilization of their supramolecular complex through C-H···π and N+···π1,4DMB interactions...
August 14, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28803552/effect-of-acaricidal-components-isolated-from-lettuce-lactuca-sativa-on-carmine-spider-mite-tetranychus-cinnabarinus-boisd
#10
M Li, Y Zhang, W Ding, J Luo, S Li, Q Zhang
This study aimed to evaluate the acaricidal activity of lettuce (Lactuca sativa) extracts against carmine spider mites (Tetranychus cinnabarinus Boisd.) and isolate the acaricidal components. Acaricidal activities of lettuce extracts isolated from different parts (the leaf, root and seed) using various solvents (petroleum ether, acetone and methanol) were evaluated with slide-dip bioassay and relatively high median lethal concentration (LC50) values were detected. Acetone extracts of lettuce leaves harvested in July and September were fractionated and isolated with silica gel and thin-layer chromatography...
August 14, 2017: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/28801891/monitoring-of-busulphan-concentrations-in-children-undergone-hematopoietic-stem-cell-transplantation-unicentric-experience-over-10%C3%A2-years
#11
Maura Faraci, Carmine Tinelli, Edoardo Lanino, Stefano Giardino, Massimiliano Leoni, Marta Ferretti, Elio Castagnola, Monica Broglia, Annalisa De Silvestri, Daniela Di Martino, Antonella Bartoli
BACKGROUND AND OBJECTIVES: The aim of this report is to describe the experience in the management of busulphan-based conditioning regimen administered before hematopoietic stem cell transplantation (HSCT) in children. METHODS: We report the values of the first dose AUC (area under the concentration-time curve, normal target between 3600 and 4800 ng·h/mL) in children treated with oral and intravenous busulphan, and we analyze the impact of some clinical variables in this cohort of patients...
August 11, 2017: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/28799754/on-the-threading-of-an-inherently-directional-calixarene-wheel-with-oriented-ammonium-axles
#12
Pellegrino La Manna, Carmen Talotta, Carmine Gaeta, Annunziata Soriente, Margherita De Rosa, Placido Neri
The threading of mono-stoppered alkylbenzylammonium axles 7+ and 8+ with the calix[6]-wheel 3 can occurs by both the routes of entering of the macrocycle 3 in the cone conformation: through-the-exo-rim and the through-the-endo-rim passage. Thus, under thermodynamic conditions, with both the axles 7+ and 8+ the two possible oriented calix[2]pseudorotaxane, namely endo-benzyl and endo-alkyl, are formed with a stereoselectivity controlled by endo-alkyl rule. Interestingly, by 1H NMR monitoring of the threading process between 8+ and 3, we revealed two calix[2]pseudorotaxane isomers in which the calix-weel adopts a 1,2,3-alternate and cone conformations, respectively, the kinetic and thermodynamic species...
August 11, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28799277/the-italian-compassionate-use-of-sofosbuvir-itacops-observational-cohort-study-for-the-treatment-of-recurrent-hepatitis-c-clinical-and-virological-outcomes
#13
Paola Carrai, Cristina Morelli, Gabriella Cordone, Antonietta Romano, Mariarosa Tamé, Raffaella Lionetti, Giada Pietrosi, Ilaria Lenci, Guido Piai, Francesco Paolo Russo, Carmine Coppola, Mario Melazzini, Simona Montilla, Luca Pani, Sandra Petraglia, Pierluigi Russo, Maria Paola Trotta, Silvia Martini, Pierluigi Toniutto
Direct antivirals are available for treating recurrent hepatitis C (RHC). This study reported outcomes of 424 patients with METAVIR F3-F4 RHC who were treated for 24 weeks with sofosbuvir/ribavirin and followed for 12 weeks within the Italian sofosbuvir compassionate use program. In 55 patients, daclatasvir or simeprevir were added. Child-Pugh class and MELD scores were evaluated at baseline and 36 weeks after the start of therapy. The sustained viral response (SVR) was 86.7% (316/365) in patients who received sofosbuvir/ribavirin and 98...
August 11, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28797564/impact-of-anxiety-apathy-and-reduced-functional-autonomy-on-perceived-quality-of-life-in-parkinson-s-disease
#14
Alfonsina D'Iorio, Carmine Vitale, Fausta Piscopo, Chiara Baiano, Anna Paola Falanga, Katia Longo, Marianna Amboni, Paolo Barone, Gabriella Santangelo
INTRODUCTION: Parkinson's disease (PD) is characterized by a wide spectrum of non-motor symptoms that may impact negatively on the activities of the patient's daily life and reduce Health-related quality of life (HRQoL). The present study explored the impact of specific non-motor symptoms on the HRQoL in PD. METHODS: Eighty-four outpatients underwent the Montreal Cognitive Assessment (MoCA) assessing global functioning and several questionnaires to assess depression, apathy, impulse control disorders (ICD), anxiety, anhedonia and functional impact of cognitive impairment...
August 5, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28793778/peroxiredoxin-2-a-novel-regulator-of-iron-homeostasis-in-ineffective-erythropoiesis
#15
Alessandro Matte, Luigia De Falco, Enrica Federti, Anna Cozzi, Achille Iolascon, Sonia Levi, Narla Mohandas, Alberto Zamo, Mariasole Bruno, Christophe Leboeuf, Anne Janin, Angela Siciliano, Thomas Ganz, Giorgia Federico, Francesca Carlomagno, Sebastian Mueller, Ines Silva, Carmine Carbone, Davide Melisi, D W Kim, Soo Young Choi, Lucia DE Franceschi
AIMS: Iron-overload (IO) is a life-threatening complication of chronic hemolytic disorders such as β-thalassemia. IO results in severe cellular oxidative damage, leading to organ failure. Peroxiredoxin-2 (Prx2), a typical 2-cysteine-(Cys)-peroxiredoxin, is an important component of cyto-protective system, but its response to IO is still to be fully defined. RESULTS: We studied the effects of IO on Prx2-knockout mice (Prx2-/-). The absence of Prx2 enhanced toxicity due to IO on erythropoiesis...
August 10, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28782730/nbn-superconducting-nanonetwork-fabricated-using-porous-silicon-templates-and-high-resolution-electron-beam-lithography
#16
Matteo Salvato, Reza Baghdadi, Carla Cirillo, Serghej L Prischepa, Alexey Dolgiy, Vitaly Bondarenko, Floriana Lombardi, Carmine Attanasio
Superconducting NbN nanonetworks with a very small number of interconnected nanowires, with diameter of the order of 4 nm, are fabricated combining a bottom-up (use of porous silicon nanotemplates) with a top-down technique (high-resolution electron beam lithography). The method is easy to control and allows to fabricate, on a robust support, devices with electrical properties close to a one-dimensional superconductor that can be fruitfully used for novel applications.
August 7, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28781968/impact-of-ospemifene-on-quality-of-life-and-sexual-function-in-young-survivors-of-cervical-cancer-a-prospective-study
#17
Nicoletta De Rosa, Giada Lavitola, Pierluigi Giampaolino, Ilaria Morra, Carmine Nappi, Giuseppe Bifulco
BACKGROUND: Cervical cancer (CC) treatments impact quality of life (QoL) and sexual function (SF) of survivors. Treatment options to reduce sexual dysfunction are limited. The aim of this study was to assess the effectiveness of ospemifene in CC survivors with clinical signs and symptoms of vulvovaginal atrophy (VVA) focusing on their QoL and SF. MATERIALS AND METHODS: Fifty-two patients with previous diagnosis of stage I-IIa CC suffering from VVA and treated with ospemifene were enrolled into a single arm prospective study...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28780190/targeting-eph-ephrin-system-in-cancer-therapy
#18
REVIEW
Alessio Lodola, Carmine Giorgio, Matteo Incerti, Ilaria Zanotti, Massimiliano Tognolini
It is well established that the Eph/ephrin system plays a central role in the embryonic development, with minor implications in the physiology of the adult. However, it is overexpressed and deregulated in a variety of tumors, with a primary involvement in tumorigenesis, tumor angiogenesis, metastasis development, and cancer stem cell regeneration. Targeting the Eph/ephrin system with biologicals, including antibodies and recombinant proteins, reduces tumor growth in animal models of hematological malignancies, breast, prostate, colon, head and neck cancers and glioblastoma...
July 18, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28775047/mortality-in-pulmonary-arterial-hypertension-prediction-by-the-2015-european-pulmonary-hypertension-guidelines-risk-stratification-model
#19
Marius M Hoeper, Tilmann Kramer, Zixuan Pan, Christina A Eichstaedt, Jens Spiesshoefer, Nicola Benjamin, Karen M Olsson, Katrin Meyer, Carmine Dario Vizza, Anton Vonk-Noordegraaf, Oliver Distler, Christian Opitz, J Simon R Gibbs, Marion Delcroix, H Ardeschir Ghofrani, Doerte Huscher, David Pittrow, Stephan Rosenkranz, Ekkehard Grünig
The 2015 European pulmonary hypertension (PH) guidelines propose a risk stratification strategy for patients with pulmonary arterial hypertension (PAH). Low-, intermediate- and high-risk strata are defined by estimated 1-year mortality risks of <5%, 5-10% and >10%, respectively. This risk assessment strategy awaits validation.We analysed data from patients with newly diagnosed PAH enrolled into COMPERA (Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension), a European-based PH registry...
August 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28773937/an-experimental-and-theoretical-investigation-of-the-electronic-structures-and-photoelectrical-properties-of-ethyl-red-and-carminic-acid-for-dssc-application
#20
Chaofan Sun, Yuanzuo Li, Peng Song, Fengcai Ma
The photoelectrical properties of two dyes-ethyl red and carminic acid-as sensitizers of dye-sensitized solar cells were investigated in experiments herein described. In order to reveal the reason for the difference between the photoelectrical properties of the two dyes, the ground state and excited state properties of the dyes before and after adsorbed on TiO₂ were calculated via density functional theory (DFT) and time-dependent DFT (TDDFT). The key parameters including the light harvesting efficiency (LHE), the driving force of electron injection ( Δ G inject ) and dye regeneration ( Δ G regen ), the total dipole moment ( μ normal ), the conduction band of edge of the semiconductor ( Δ E CB ), and the excited state lifetime (τ) were investigated, which are closely related to the short-circuit current density ( J sc ) and open circuit voltage ( V oc )...
October 1, 2016: Materials
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