keyword
https://read.qxmd.com/read/37611637/tgf-%C3%AE-1-signaling-and-smad7-control-t-cell-responses-in-health-and-immune-mediated-disorders
#1
REVIEW
Federica Laudisi, Carmine Stolfi, Ivan Monteleone, Giovanni Monteleone
Transforming growth factor (TGF)-β1, a member of the TGF-β superfamily, is produced by many immune and non-immune cells and has pleiotropic effects on both innate and adaptive immunity, especially in the control of T cell differentiation and function. Consistently, loss of TGF-β1 function is associated with exacerbated T cell-dependent inflammatory responses that culminate in pathological processes in allergic and immune-mediated diseases. In this review, we highlight the roles of TGF-β1 in immunity, focusing mainly on its ability to promote differentiation of regulatory T cells, T helper (Th)-17, and Th9 cells, thus contributing to amplifying or restricting T cell responses in health and human diseases (e...
August 23, 2023: European Journal of Immunology
https://read.qxmd.com/read/37469218/mind-and-skin-exploring-the-links-between-inflammation-sleep-disturbance-and-neurocognitive-function-in-patients-with-atopic-dermatitis
#2
REVIEW
Shona Cameron, Ali Donnelly, Conor Broderick, Tomoki Arichi, Ullrich Bartsch, Paola Dazzan, Jesper Elbeling, Emma Godfrey, Paul Gringras, Lauren C Heathcote, Desaline Joseph, Tobias C Wood, Carmine Pariante, Katya Rubia, Carsten Flohr
Atopic dermatitis (AD) is a chronic, pruritic and inflammatory, dry skin condition with many known comorbidities. These include airway disease, food allergies, atopic eye disease and autoimmune conditions. Furthermore, there is often significant sleep disturbance as well as increased psychological distress and mental health problems. Severe AD therefore often has a significant impact on the quality of life of both patients and their families. In this review we discuss recent findings on the putative links between AD, its association with itch, sleep disturbance and neuropsychiatric morbidity, including the role of inflammation in these conditions...
July 19, 2023: Allergy
https://read.qxmd.com/read/37009191/a-case-report-of-allergic-hypersensitivity-to-color-additives-in-slurpee%C3%A2-beverages
#3
JOURNAL ARTICLE
David B Weisbrod, Dennis L Caruana, David Li, Leo Wan, Anthony M Szema
Introduction : Many commercially available foods and beverages contain color additives to which patients may develop allergic hypersensitivity. Several color additives currently approved for commercial sale in the United States have raised health concerns to a varying degree as testing and evidence of carcinogenicity, genotoxicity, and hypersensitivity has thus far been inadequate. Common uses for color additives include baked goods (eg, cakes, pastries, candy), flavored dairy products such as yogurt, sports-themed drinks (eg, Gatorade® Fruit Punch), and red-dyed Slurpee® beverages...
March 2023: Yale Journal of Biology and Medicine
https://read.qxmd.com/read/36243108/inter-intra-instrument-comparison-and-standardization-of-a-10-color-immunophenotyping-for-b-and-t-cell-non-hodgkin-lymphoma-diagnosis-and-monitoring
#4
JOURNAL ARTICLE
Marisa Gorrese, Angela Bertolini, Lucia Fresolone, Annapaola Campana, Luca Pezzullo, Roberto Guariglia, Laura Mettivier, Paola Manzo, Bianca Cuffa, Francesca D'Alto, Bianca Serio, Carmine Selleri, Valentina Giudice
Harmonization of flow cytometry protocols from instrument settings to antibody panel and reagents is highly encouraged for inter-laboratory data comparison in both research and clinical settings, especially for minimal residual disease monitoring evaluation in hematological diseases across centers. Here, we described inter-intra instrument comparison of two standardized 10-color staining dried tubes for B- and T-cell lymphoproliferative disorder diagnosis and monitoring on two different flow cytometers, a Beckman Coulter NaviosEx and a Beckman Coulter DxFlex...
December 2022: Journal of Immunological Methods
https://read.qxmd.com/read/35369613/carmine-allergy-in-urticaria-patients
#5
JOURNAL ARTICLE
Beata Sadowska, Marlena Sztormowska, Marika Gawinowska, Marta Chełmińska
Introduction: Carmine, a commonly used natural red dye, can cause immediate and delayed allergic reactions, which are frequently overlooked. Aim: To assess the incidence of carmine allergy and its clinical significance based on the placebo-controlled oral challenge in urticaria patients and suspected hypersensitivity to food additives. Material and methods: Patients' histories were recorded by means of a standardized questionnaire. The subjects underwent skin prick tests and patch tests for carmine, while the level of specific IgE was measured in 52 patients...
February 2022: Postȩpy Dermatologii i Alergologii
https://read.qxmd.com/read/33636560/cateslytin-abrogates-lipopolysaccharide-induced-cardiomyocyte-injury-by-reducing-inflammation-and-oxidative-stress-through-toll-like-receptor-4-interaction
#6
JOURNAL ARTICLE
Carmine Rocca, Anna De Bartolo, Fedora Grande, Bruno Rizzuti, Teresa Pasqua, Francesca Giordano, Maria Concetta Granieri, Maria Antonietta Occhiuzzi, Antonio Garofalo, Nicola Amodio, Maria Carmela Cerra, Francis Schneider, Maria Luisa Panno, Marie Hélène Metz-Boutigue, Tommaso Angelone
Global public health is threatened by new pathogens, antimicrobial resistant microorganisms and a rapid decline of conventional antimicrobials efficacy. Thus, numerous medical procedures become life-threating. Sepsis can lead to tissue damage such as myocardium inflammation, associated with reduction of contractility and diastolic dysfunction, which may cause death. In this perspective, growing interest and attention are paid on host defence peptides considered as new potential antimicrobials. In the present study, we investigated the physiological and biochemical properties of Cateslytin (Ctl), an endogenous antimicrobial chromogranin A-derived peptide, in H9c2 cardiomyocytes exposed to lipopolysaccharide (LPS) infection...
February 23, 2021: International Immunopharmacology
https://read.qxmd.com/read/33340568/microneedles-for-painless-transdermal-immunotherapeutic-applications
#7
JOURNAL ARTICLE
Hamed Amani, Mohammad-Ali Shahbazi, Carmine D'Amico, Flavia Fontana, Samin Abbaszadeh, Hélder A Santos
Immunotherapy has recently garnered plenty of attention to improve the clinical outcomes in the treatment of various diseases. However, owing to the dynamic nature of the immune system, this approach has often been challenged by concerns regarding the lack of adequate long-term responses in patients. The development of microneedles (MNs) has resulted in the improvement and expansion of immuno-reprogramming strategies due to the housing of high accumulation of dendritic cells, macrophages, lymphocytes, and mast cells in the dermis layer of the skin...
December 16, 2020: Journal of Controlled Release
https://read.qxmd.com/read/33074937/expanding-patch-testing-beyond-the-baseline-series-usefulness-of-customized-antimicrobials-vehicles-and-cosmetics-series
#8
JOURNAL ARTICLE
Catherine Besner Morin, Denis Sasseville
BACKGROUND: Testing cosmetics and their ingredients is essential to avoid missing relevant allergens and to monitor fluctuating incidence of hypersensitivity. OBJECTIVE: The aim of this study was to review the usefulness of patch testing with a customized antimicrobials, vehicles, and cosmetics (AVC) series over 15 years at a single Canadian site. METHODS: Between January 1, 2005, and December 31, 2019, patients suspected of having cosmetics allergy were patch tested with a 40-allergen AVC series in addition to the North American Contact Dermatitis Group standard screening series...
October 16, 2020: Dermatitis
https://read.qxmd.com/read/32807620/adverse-reactions-to-food-additives-in-children-a-retrospective-study-and-a-prospective-survey
#9
JOURNAL ARTICLE
A Lemoine, S Pauliat-Desbordes, P Challier, P Tounian
BACKGROUND: Allergic reactions to food additives are often suspected by families. The aim of this study was to describe oral food challenge (OFC) outcomes in a pediatric cohort with a suspected diagnosis of allergy to food additives (food dyes or sodium benzoate). METHODS: All patients who underwent an open OFC to carmine red, cochineal red, erythrosine, patent blue V, tartrazine, yellow sunset S, and/or sodium benzoate were included. A survey was sent to families after testing to evaluate whether the OFC results had altered feeding behaviors with food additives...
August 15, 2020: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://read.qxmd.com/read/30740350/allergy-to-carminic-acid-in-vitro-evidence-of-involvement-of-protein-binding-hapten
#10
JOURNAL ARTICLE
Mika Osumi, Masao Yamaguchi, Naoya Sugimoto, Maho Suzukawa, Hidenori Arai, Hiroshi Akiyama, Hiroyuki Nagase, Ken Ohta
We previously described a rare case of anaphylaxis presumably induced by carminic acid in cochineal dye used as a food additive. In this study, highly pure carminic acid was added to an albumin-containing buffer at various concentrations, followed by serial dilution. Varying the mixing ratio of carminic acid and albumin affected the extent of histamine release from passively sensitized basophils. Similar basophil histamine release occurred with carminic acid-globulin solutions. These results provide experimental evidence indicating that basophil activation is dependent on hapten (carminic acid) and carrier (protein) interaction...
January 2019: Asia Pacific Allergy
https://read.qxmd.com/read/29731166/insect-food-allergy-and-allergens
#11
JOURNAL ARTICLE
Steffie de Gier, Kitty Verhoeckx
Insects represent an alternative for meat and fish in satisfying the increasing demand for sustainable sources of nutrition. Approximately two billion people globally consume insects. They are particularly popular in Asia, Latin America, and Africa. Most research on insect allergy has focussed on occupational or inhalation allergy. Research on insect food safety, including allergenicity, is therefore of great importance. The objective of this review is to provide an overview of cases reporting allergy following insect ingestion, studies on food allergy to insects, proteins involved in insect allergy including cross-reactive proteins, and the possibility to alter the allergenic potential of insects by food processing and digestion...
August 2018: Molecular Immunology
https://read.qxmd.com/read/29705083/cochineal-dye-induced-immediate-allergy-review-of-japanese-cases-and-proposed-new-diagnostic-chart
#12
JOURNAL ARTICLE
Naoko Takeo, Masashi Nakamura, Satoshi Nakayama, Osamu Okamoto, Naoki Sugimoto, Shinichi Sugiura, Nayu Sato, Susumu Harada, Masao Yamaguchi, Naoya Mitsui, Yumiko Kubota, Kayoko Suzuki, Makoto Terada, Akiyo Nagai, Junko Sowa-Osako, Yutaka Hatano, Hiroshi Akiyama, Akiko Yagami, Sakuhei Fujiwara, Kayoko Matsunaga
BACKGROUND: Cochineal dye is used worldwide as a red coloring in foods, drinks, cosmetics, quasi-drugs, and drugs. The main component of the red color is carminic acid (CA). Carmine is an aluminum- or calcium-chelated product of CA. CA and carmine usually contain contaminating proteins, including a 38-kDa protein thought to be the primary allergen. Severe allergic reactions manifest as anaphylaxis. The aim of this study was to review all Japanese reported cases and propose useful diagnostic chart...
October 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://read.qxmd.com/read/27824741/intraoperative-cystoscopic-evaluation-of-ureteral-patency-a-randomized-controlled-trial
#13
RANDOMIZED CONTROLLED TRIAL
Luis Espaillat-Rijo, Lauren Siff, Alexandriah N Alas, Sami A Chadi, Stephen Zimberg, Sneha Vaish, G Willy Davila, Matthew Barber, Eric A Hurtado
OBJECTIVE: To compare different modalities to aid in the evaluation of intraoperative ureteral patency on cystoscopy in the postindigo carmine era. METHODS: In a randomized controlled trial, participants undergoing pelvic surgery were randomized into one of four groups: saline distention (control), 10% dextrose distention, oral phenazopyridine, or intravenous sodium fluorescein. Our primary outcome was visibility of the ureteral jets. Secondary outcomes included surgeon satisfaction; adverse reactions including allergies, urinary tract infections, urinary retention, cystoscopy times, and ureteral obstruction; and delayed diagnosis...
December 2016: Obstetrics and Gynecology
https://read.qxmd.com/read/27610263/severe-hypotension-hypoxia-and-subcutaneous-erythema-induced-by-indigo-carmine-administration-during-open-prostatectomy
#14
JOURNAL ARTICLE
Koichiro Nandate, Bryan B Voelzke
Indigo carmine (also known as 5,5'-indigodisulfonic acid sodium salt or indigotine) is a blue dye that is administered intravenously to examine the urinary tract and usually is biologically safe and inert. Indigo carmine rarely may cause adverse reactions. We treated a 66-year-old man who had general anesthesia and radical retropubic prostatectomy for prostate cancer. He had a previous history of allergy to bee sting with nausea, vomiting, and dizziness. Within 1 minute after injection of indigo carmine for evaluation of the ureters, the patient developed hypotension to 40 mmHg, severe hypoxia (the value of SpO2 (peripheral capillary oxygen saturation) was 75% on 40% inspired oxygen concentration), poor air movement and bilateral diffuse wheezing on auscultation, and marked subcutaneous erythema at the upper extremities...
2016: Case Reports in Urology
https://read.qxmd.com/read/27518882/occupational-allergy-to-horse-allergens-more-than-exposure-to-horses
#15
LETTER
Gennaro Liccardi, Luigino Calzetta, Carmine Sapio, Paola Rogliani
No abstract text is available yet for this article.
2016: International Journal of Occupational Medicine and Environmental Health
https://read.qxmd.com/read/26549338/an-oral-challenge-test-with-carmine-red-e120-in-skin-prick-test-positive-patients
#16
JOURNAL ARTICLE
J Liippo, K Lammintausta
BACKGROUND: Positive skin prick test reactions to carmine red (E120) occur in approximately 3% of the patients studied for food allergy. Carmine ingestion associated systemic symptoms are occasionally suspected, but sufficient information of proven carmine allergy is not available. PATIENTS AND METHODS: To analyse carmine related symptoms in skin prick test positive patients a cohort of 23 patients with suspected allergy to carmine red was subjected to a single-blind placebo-controlled oral challenge test with carmine red...
November 2015: European Annals of Allergy and Clinical Immunology
https://read.qxmd.com/read/25562550/oxidative-stress-markers-in-patients-with-hymenoptera-venom-allergy
#17
JOURNAL ARTICLE
Vincenzo Patella, Cristoforo Incorvaia, Paola Lucia Minciullo, Carmine Oricchio, Salvatore Saitta, Giovanni Florio, Antonella Saija, Sebastiano Gangemi
Oxidative stress occurs in many allergic and immunologic disorders as a result of the imbalance between the endogenous production of free reactive oxygen species (ROS) and/or the reduction of antioxidant defense mechanisms. Advanced glycation end products (AGEs), advanced oxidation protein products (AOPPs), and nitrosylated proteins (NPs) can be used as markers of oxidative stress and inflammation. Our objective was to examine the serum levels of AGEs, AOPPs, and NPs in patients with allergic reactions to hymenoptera venom before and after ultrarush venom immunotherapy (VIT)...
January 2015: Allergy and Asthma Proceedings:
https://read.qxmd.com/read/24124641/characteristics-of-candidates-for-allergen-immunotherapy
#18
JOURNAL ARTICLE
Giorgio Ciprandi, Cristoforo Incorvaia, Ilaria Dell'Albani, Simonetta Masieri, Carmine Cavaliere, Paola Puccinelli, Franco Frati
Allergic rhinitis (AR) may be cured by allergen immunotherapy (AIT). However, patient characteristics for prescribing AIT are not well defined. This study aimed at evaluating the patient's profile to be a candidate for AIT in a cohort of patients suffering from AR, evaluated in 20 Italian Allergy or Ear, Nose, and Throat Centers. The study has been performed on 198 patients (98 men; mean age, 26.8 years) with AR (assessed by Allergic Rhinitis and Its Impact on Asthma [ARIA] criteria). The kind and the number of prescribed allergen extracts, type of diagnosis, severity of symptoms, and patient's perception of symptoms and drug use were evaluated...
2013: Allergy & Rhinology
https://read.qxmd.com/read/23377335/medication-dyes-as-a-source-of-drug-allergy
#19
JOURNAL ARTICLE
Robert A Swerlick, Caren F Campbell
Excipients are defined as inert substances added to a drug or food to confer a suitable consistency, appearance, or form. They may be added for bulk, to change dissolution or the kinetics of absorption, to improve stability, to influence palatability, or to create a distinctive appearance. The last function may depend heavily on the use of coloring agents, especially when there are multiple dosages (such as with warfarin), and dose confusion may result in profound complications. While described as inert, excipients have been associated with triggering immunological reactions, although this is almost never considered in common practice when patients have reactions to medications, even when they appear to react to many different and distinct drugs...
January 2013: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/23282762/eight-years-of-severe-allergic-reactions-in-finland-a-register-based-report
#20
JOURNAL ARTICLE
Soili Mäkinen-Kiljunen, Tari Haahtela
BACKGROUND: : No data have been available on severe allergic reactions in Finland. MATERIALS AND METHODS: : We summarize the data accumulated from 2000 to 2007 in the national register established at the Skin and Allergy Hospital of the Helsinki University Central Hospital, where physicians voluntarily report on patients with severe allergic reactions. RESULTS: : During the period, the 530 reported cases of severe allergic reactions represented an annual frequency of 0...
November 2008: World Allergy Organization Journal
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