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https://www.readbyqxmd.com/read/29350174/automated-peritoneal-dialysis-could-rapidly-improve-left-heart-failure-by-increasing-peritoneal-dialysis-ultrafiltration-a-single-center-observational-clinical-study%C3%A2
#1
Cong Yang, Jixing Liu, Nirong Gong, Yanhong Lin, Yanfang He, Zhixiu Yi, Liping Hu, Jianping Jiang, Jun Ai
Ultrafiltration failure (UFF) is a major cause of water retention, left heart failure (LHF), and peritoneal dialysis (PD) failure. Automated peritoneal dialysis (APD) might have better ultrafiltration (UF) than continuous ambulatory peritoneal dialysis (CAPD). Here, we have studied whether short-term APD could increase UF and improve LHF. 47 patients were included in this study from December 1, 2015, to January 1, 2017. All patients had been treated with CAPD before they came to our center and were treated with APD in the hospital...
January 19, 2018: Clinical Nephrology
https://www.readbyqxmd.com/read/29340842/application-of-automated-peritoneal-dialysis-in-urgent-start-peritoneal-dialysis-patients-during-the-break-in-period
#2
Shengmao Liu, Xiaohua Zhuang, Min Zhang, Yanfeng Wu, Min Liu, Sibo Guan, Shujun Liu, Lining Miao, Wenpeng Cui
OBJECTIVE: Whether automated peritoneal dialysis (APD) is a feasible strategy for urgent-start peritoneal dialysis (PD) therapy during the break-in period remains unclear. This study was conducted to compare the efficacy as well as complications among three PD modes during the break-in period. METHODS: Ninety-six patients treated with urgent-start PD after catheterization were retrospectively analyzed. Patients were divided into three groups, incremental continuous ambulatory PD (CAPD) group (n = 26); APD group (n = 42); and APD-CAPD group (n = 28)...
January 16, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29340285/quantitative-bone-scan-lesion-area-as-an-early-surrogate-outcome-measure-indicative-of-overall-survival-in-metastatic-prostate-cancer
#3
Matthew S Brown, Grace Hyun J Kim, Gregory H Chu, Bharath Ramakrishna, Martin Allen-Auerbach, Cheryce P Fischer, Benjamin Levine, Pawan K Gupta, Christiaan W Schiepers, Jonathan G Goldin
A clinical validation of the bone scan lesion area (BSLA) as a quantitative imaging biomarker was performed in metastatic castration-resistant prostate cancer (mCRPC). BSLA was computed from whole-body bone scintigraphy at baseline and week 12 posttreatment in a cohort of 198 mCRPC subjects (127 treated and 71 placebo) from a clinical trial involving a different drug from the initial biomarker development. BSLA computation involved automated image normalization, lesion segmentation, and summation of the total area of segmented lesions on bone scan AP and PA views as a measure of tumor burden...
January 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29331072/transcranial-ultrasonographic-image-analysis-system-for-decision-support-in-parkinson-disease
#4
Andrius Sakalauskas, Vita Špečkauskienė, Kristina Laučkaitė, Rytis Jurkonis, Daiva Rastenytė, Arūnas Lukoševičius
OBJECTIVES: Transcranial ultrasonography (US) is a relatively new neuroimaging modality proposed for early diagnostics of Parkinson disease (PD). The main limitation of transcranial US image-based diagnostics is a high degree of subjectivity caused by low quality of the transcranial images. The article presents a developed image analysis system and evaluates the potential of automated image analysis on transcranial US. METHODS: The system consists of algorithms for the segmentation and assessment of informative brain regions (midbrain and substantia nigra) and a decision support subsystem, which is equipped with 64 classification algorithms...
January 13, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29311200/remote-patient-management-in-automated-peritoneal-dialysis-a-promising-new-tool
#5
Valérie Jotterand Drepper, Pierre-Yves Martin, Catherine Stoermann Chopard, James A Sloand
Remote patient management (RPM) has the potential to help clinicians detect early issues, allowing intervention prior to development of more significant problems. A 23-year-old end-stage kidney disease patient required urgent start of renal replacement therapy. A newly available automated peritoneal dialysis (APD) RPM system with cloud-based connectivity was implemented in her care. Pre-defined RPM threshold parameters were set to identify clinically relevant issues. Red flag dashboard alerts heralded prolonged drain times leading to clinical evaluation with subsequent diagnosis of and surgical repositioning for catheter displacement, although it took several days for newly-RPM-exposed staff to recognize this issue...
January 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/29309313/automated-mechanical-peripheral-stimulation-improves-gait-parameters-in-subjects-with-parkinson-s-disease-and-freezing-of-gait-a-randomized-clinical-trial
#6
Camila Pinto, Aline de Souza Pagnussat, Ana Francisca Rozin Kleiner, Ritchele Redivo Marchese, Ana Paula Salazar, Carlos R M Rieder, Manuela Galli
OBJECTIVE: This study aimed to assess spatiotemporal gait parameters and lower limbs range of motion (ROM) in subjects with Parkinson's Disease (PD) and freezing of gait (FOG), treated with Automated Mechanical Peripheral Stimulation (AMPS) or AMPS SHAM (placebo). DESIGN: This randomized clinical trial included thirty subjects allocated into two groups: AMPS (15 subjects with PD) and AMPS SHAM (15 subjects with PD). Fourteen age-matched healthy subjects were also included as a REFERENCE group...
January 5, 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29305123/automated-visualization-and-quantification-of-spiral-artery-blood-flow-entering-the-first-trimester-placenta-using-3-d-power-doppler-ultrasound
#7
Gordon N Stevenson, J Alison Noble, Alec W Welsh, Lawrence Impey, Sally L Collins
The goal of our research was to quantify the placental vascularity in 3-D at 11-13 + 6 wk of pregnancy at precise distances from the utero-placental interface (UPI) using 3-D power Doppler ultrasound. With this automated image analysis technique, differences in vascularity between normal and pathologic pregnancies may be observed. The algorithm was validated using a computer-generated image phantom and applied retrospectively in 143 patients. The following features from the PD data were recorded: The number of spiral artery jets into the inter-villous space, total geometric and PD area...
January 2, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29299352/a-semi-automated-assessment-of-sarcopenia-using-psoas-area-and-density-predicts-outcomes-after-pancreaticoduodenectomy-for-pancreatic-malignancy
#8
Jukes P Namm, Kiran H Thakrar, Chi-Hsiung Wang, Susan J Stocker, Malini D Sur, Jonathan Berlin, William Dale, Mark S Talamonti, Kevin K Roggin
Background: Sarcopenia has been associated with increased adverse outcomes after major abdominal surgery. Sarcopenia defined as decreased muscle volume or increased fatty infiltration may be a proxy for frailty. In conjunction with other preoperative clinical risk factors, radiographic measures of sarcopenia using both muscle size and density may enhance prediction of outcomes after pancreaticoduodenectomy (PD) for malignancy. Methods: Preoperative computed tomography (CT) scans of patients undergoing PD for malignancy were analyzed from a prospective pancreatic surgery database...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29275185/characteristics-of-gray-matter-morphological-change-in-parkinson-s-disease-patients-with-semantic-abstract-reasoning-deficits
#9
Li Wang, Kun Nie, Xin Zhao, Shujun Feng, Sifen Xie, Xuetao He, Guixian Ma, Limin Wang, Zhiheng Huang, Biao Huang, Yuhu Zhang, Lijuan Wang
BACKGROUND: Semantic abstract reasoning(SAR) is an important executive domain that is involved in semantic information processing and enables one to make sense of the attributes of objects, facts and concepts in the world. We sought to investigate whether Parkinson's disease subjects(PDs) have difficulty in SAR and to examine the associated pattern of gray matter morphological changes. METHODS: Eighty-six PDs and 30 healthy controls were enrolled. PDs were grouped into PD subjects with Similarities preservation(PDSP, n = 62) and PD subjects with Similarities impairment(PDSI, n = 24)according to their performance on the Similarities subtest of the Wechsler Adult Intelligence Scale...
December 21, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29210358/computer-aided-assessment-of-breast-density-comparison-of-supervised-deep-learning-and-feature-based-statistical-learning
#10
Songfeng Li, Jun Wei, Heang-Ping Chan, Mark A Helvie, Marilyn A Roubidoux, Yao Lu, Chuan Zhou, Lubomir M Hadjiiski, Ravi K Samala
Breast density is one of the most significant factors that is associated with cancer risk. In this study, our purpose was to develop a supervised deep learning approach for automated estimation of percentage density (PD) on digital mammograms (DM). The input "for processing" DM was first log-transformed, enhanced by a multi-resolution preprocessing scheme, and subsampled to a pixel size of 800µm×800µm from 100µm×100µm. A deep convolutional neural network (DCNN) was trained to estimate a probability map of breast density (PMD) by using a domain adaptation resampling method...
December 6, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29208908/multiplex-three-dimensional-optical-mapping-of-tumor-immune-microenvironment
#11
Steve Seung-Young Lee, Vytautas P Bindokas, Stephen J Kron
Recent developments in optical tissue clearing and microscopic imaging have advanced three-dimensional (3D) visualization of intact tissues and organs at high resolution. However, to expand applications to oncology, critical limitations of current methods must be addressed. Here we describe transparent tissue tomography (T3) as a tool for rapid, three-dimensional, multiplexed immunofluorescent tumor imaging. Cutting tumors into sub-millimeter macrosections enables simple and rapid immunofluorescence staining, optical clearing, and confocal microscope imaging...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29181872/validation-of-t1w-based-segmentations-of-white-matter-hyperintensity-volumes-in-large-scale-datasets-of-aging
#12
Mahsa Dadar, Josefina Maranzano, Simon Ducharme, Owen T Carmichael, Charles Decarli, D Louis Collins
INTRODUCTION: Fluid-attenuated Inversion Recovery (FLAIR) and dual T2w and proton density (PD) magnetic resonance images (MRIs) are considered to be the optimum sequences for detecting white matter hyperintensities (WMHs) in aging and Alzheimer's disease populations. However, many existing large multisite studies forgo their acquisition in favor of other MRI sequences due to economic and time constraints. METHODS: In this article, we have investigated whether FLAIR and T2w/PD sequences are necessary to detect WMHs in Alzheimer's and aging studies, compared to using only T1w images...
November 27, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29177202/applying-physical-science-techniques-and-cern-technology-to-an-unsolved-problem-in-radiation-treatment-for-cancer-the-multidisciplinary-voxtox-research-programme
#13
Neil G Burnet, Jessica E Scaife, Marina Romanchikova, Simon J Thomas, Amy M Bates, Emma Wong, David J Noble, Leila Ea Shelley, Simon J Bond, Julia R Forman, Andrew Cf Hoole, Gillian C Barnett, Frederic M Brochu, Michael Pd Simmons, Raj Jena, Karl Harrison, Ping Lin Yeap, Amelia Drew, Emma Silvester, Patrick Elwood, Hannah Pullen, Andrew Sultana, Shannon Yk Seah, Megan Z Wilson, Simon G Russell, Richard J Benson, Yvonne L Rimmer, Sarah J Jefferies, Nicolette Taku, Mark Gurnell, Andrew S Powlson, Carola-Bibiane Schönlieb, Xiaohao Cai, Michael Pf Sutcliffe, Michael A Parker
The VoxTox research programme has applied expertise from the physical sciences to the problem of radiotherapy toxicity, bringing together expertise from engineering, mathematics, high energy physics (including the Large Hadron Collider), medical physics and radiation oncology. In our initial cohort of 109 men treated with curative radiotherapy for prostate cancer, daily image guidance computed tomography (CT) scans have been used to calculate delivered dose to the rectum, as distinct from planned dose, using an automated approach...
June 2017: CERN IdeaSquare Journal of Experimental Innovation
https://www.readbyqxmd.com/read/29172435/the-evolution-of-chemical-high-throughput-experimentation-to-address-challenging-problems-in-pharmaceutical-synthesis
#14
Shane W Krska, Daniel A DiRocco, Spencer D Dreher, Michael Shevlin
The structural complexity of pharmaceuticals presents a significant challenge to modern catalysis. Many published methods that work well on simple substrates often fail when attempts are made to apply them to complex drug intermediates. The use of high-throughput experimentation (HTE) techniques offers a means to overcome this fundamental challenge by facilitating the rational exploration of large arrays of catalysts and reaction conditions in a time- and material-efficient manner. Initial forays into the use of HTE in our laboratories for solving chemistry problems centered around screening of chiral precious-metal catalysts for homogeneous asymmetric hydrogenation...
November 27, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29157745/differential-diagnosis-of-parkinsonian-syndromes-using-dopamine-transporter-and-perfusion-spect
#15
Shigetoshi Takaya, Nobukatsu Sawamoto, Tomohisa Okada, Gosuke Okubo, Sei Nishida, Kaori Togashi, Hidenao Fukuyama, Ryosuke Takahashi
OBJECTIVE: We aimed to assess whether a combined analysis of dopamine transporter (DAT)- and perfusion-SPECT images (or either) could: (1) distinguish atypical parkinsonian syndromes (APS) from Lewy body diseases (LBD; majority Parkinson disease [PD]), and (2) differentiate among APS subgroups (progressive supranuclear palsy [PSP], corticobasal syndrome [CBS], and multiple system atrophy [MSA]). METHODS: We recruited consecutive patients with neurodegenerative parkinsonian syndromes (LBD, n = 46; APS, n = 33)...
November 14, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29157260/high-resolution-and-accelerated-multi-parametric-mapping-with-automated-characterization-of-vessel-disease-using-intravascular-mri
#16
Guan Wang, Yi Zhang, Shashank Sathyanarayana Hegde, Paul A Bottomley
BACKGROUND: Atherosclerosis is prevalent in cardiovascular disease, but present imaging modalities have limited capabilities for characterizing lesion stage, progression and response to intervention. This study tests whether intravascular magnetic resonance imaging (IVMRI) measures of relaxation times (T1, T2) and proton density (PD) in a clinical 3 Tesla scanner could characterize vessel disease, and evaluates a practical strategy for accelerated quantification. METHODS: IVMRI was performed in fresh human artery segments and swine vessels in vivo, using fast multi-parametric sequences, 1-2 mm diameter loopless antennae and 200-300 μm resolution...
November 20, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29136839/chromisense-a-colourimetric-lab-on-a-disc-sensor-for-chromium-speciation-in-water
#17
G Duffy, I Maguire, Brendan Heery, Pauline Gers, J Ducrée, F Regan
The development of a centrifugal device for quantitative analysis of both chromium (III) and (VI) species in water is reported. ChromiSense is a colourimetric sensor system that has been applied to the measurement of chromium in spiked river water samples. For analysis, the sample is loaded into a reservoir on the disposable microfluidic disc, along with reagents. A centrifugal force is created by spinning the disc to pump liquids through microchannels, causing them to mix and react to form a coloured product...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29112012/semiquantitative-analysis-of-dopamine-transporter-scans-in-patients-with-parkinson-disease
#18
Sule Tinaz, Christopher Chow, Phillip H Kuo, Elizabeth A Krupinski, Hal Blumenfeld, Elan D Louis, George Zubal
PURPOSE: Dopamine transporter (DaT) imaging is an adjunct diagnostic tool in parkinsonian disorders. Interpretation of DaT scans is based on visual reads. SBRquant is an automated method that measures the striatal binding ratio (SBR) in DaT scans, but has yet to be optimized. We aimed to (1) optimize SBRquant parameters to distinguish between patients with Parkinson disease (PD) and healthy controls using the Parkinson's Progression Markers Initiative (PPMI) database and (2) test the validity of these parameters in an outpatient cohort...
January 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29084060/characterization-of-pd-l1-immunohistochemical-expression-in-cell-blocks-with-different-specimen-fixation-and-processing-methods
#19
Isaac E Lloyd, Wenhua Zhou, Benjamin L Witt, Barbara E Chadwick
Interpretative criteria for programmed death-ligand 1 (PD-L1) immunohistochemistry (IHC) have been largely based on data from formalin-fixed, paraffin-embedded tissues, despite the fact that cytologic specimens, especially cell blocks, are often the only or most readily available tissue for testing. Unlike biopsy specimens, however, cytology sample processing methods can vary markedly. The purpose of this study was to evaluate the effects of several common preanalytic variables on PD-L1 IHC. Two cell lines with strong expression of PD-L1 (H441) and no expression (MCF7) were cultured in vitro...
October 27, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29082068/imaging-of-neuronal-tissues-by-x-ray-diffraction-and-x-ray-fluorescence-microscopy-evaluation-of-contrast-and-biomarkers-for-neurodegenerative-diseases
#20
Eleonora Carboni, Jan-David Nicolas, Mareike Töpperwien, Christine Stadelmann-Nessler, Paul Lingor, Tim Salditt
We have used scanning X-ray diffraction (XRD) and X-ray fluorescence (XRF) with micro-focused synchrotron radiation to study histological sections from human substantia nigra (SN). Both XRF and XRD mappings visualize tissue properties, which are inaccessible by conventional microscopy and histology. We propose to use these advanced tools to characterize neuronal tissue in neurodegeneration, in particular in Parkinson's disease (PD). To this end, we take advantage of the recent experimental progress in x-ray focusing, detection, and use automated data analysis scripts to enable quantitative analysis of large field of views...
October 1, 2017: Biomedical Optics Express
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