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Automated PD

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https://www.readbyqxmd.com/read/29136839/chromisense-a-colourimetric-lab-on-a-disc-sensor-for-chromium-speciation-in-water
#1
G Duffy, I Maguire, Brendan Heery, Pauline Gers, J Ducrée, F Regan
The development of a centrifugal device for quantitative analysis of both chromium (III) and (VI) species in water is reported. ChromiSense is a colourimetric sensor system that has been applied to the measurement of chromium in spiked river water samples. For analysis, the sample is loaded into a reservoir on the disposable microfluidic disc, along with reagents. A centrifugal force is created by spinning the disc to pump liquids through microchannels, causing them to mix and react to form a coloured product...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29112012/semiquantitative-analysis-of-dopamine-transporter-scans-in-patients-with-parkinson-disease
#2
Sule Tinaz, Christopher Chow, Phillip H Kuo, Elizabeth A Krupinski, Hal Blumenfeld, Elan D Louis, George Zubal
PURPOSE: Dopamine transporter (DaT) imaging is an adjunct diagnostic tool in parkinsonian disorders. Interpretation of DaT scans is based on visual reads. SBRquant is an automated method that measures the striatal binding ratio (SBR) in DaT scans, but has yet to be optimized. We aimed to (1) optimize SBRquant parameters to distinguish between patients with Parkinson disease (PD) and healthy controls using the Parkinson's Progression Markers Initiative (PPMI) database and (2) test the validity of these parameters in an outpatient cohort...
November 3, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29084060/characterization-of-pd-l1-immunohistochemical-expression-in-cell-blocks-with-different-specimen-fixation-and-processing-methods
#3
Isaac E Lloyd, Wenhua Zhou, Benjamin L Witt, Barbara E Chadwick
Interpretative criteria for programmed death-ligand 1 (PD-L1) immunohistochemistry (IHC) have been largely based on data from formalin-fixed, paraffin-embedded tissues, despite the fact that cytologic specimens, especially cell blocks, are often the only or most readily available tissue for testing. Unlike biopsy specimens, however, cytology sample processing methods can vary markedly. The purpose of this study was to evaluate the effects of several common preanalytic variables on PD-L1 IHC. Two cell lines with strong expression of PD-L1 (H441) and no expression (MCF7) were cultured in vitro...
October 27, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29082068/imaging-of-neuronal-tissues-by-x-ray-diffraction-and-x-ray-fluorescence-microscopy-evaluation-of-contrast-and-biomarkers-for-neurodegenerative-diseases
#4
Eleonora Carboni, Jan-David Nicolas, Mareike Töpperwien, Christine Stadelmann-Nessler, Paul Lingor, Tim Salditt
We have used scanning X-ray diffraction (XRD) and X-ray fluorescence (XRF) with micro-focused synchrotron radiation to study histological sections from human substantia nigra (SN). Both XRF and XRD mappings visualize tissue properties, which are inaccessible by conventional microscopy and histology. We propose to use these advanced tools to characterize neuronal tissue in neurodegeneration, in particular in Parkinson's disease (PD). To this end, we take advantage of the recent experimental progress in x-ray focusing, detection, and use automated data analysis scripts to enable quantitative analysis of large field of views...
October 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/29063605/disturbance-of-verticality-perception-and-postural-dysfunction-in-parkinson-s-disease
#5
K A Schindlbeck, W Naumann, A Maier, F Ehlen, F Marzinzik, F Klostermann
OBJECTIVES: Verticality perception is known to be abnormal in Parkinson's disease (PD), but in which stage respective dysfunctions arise and how they relate to postural disorders remains to be settled. These issues were studied with respect to different dimensions of the subjective visual vertical (SVV) in relation to clinical parameters of postural control. MATERIALS & METHODS: All participants had to orientate a luminous line at random planar orientations to a strictly vertical position using an automated operator system...
October 23, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29060621/automated-vision-based-analysis-of-levodopa-induced-dyskinesia-with-deep-learning
#6
Michael H Li, Tiago A Mestre, Susan H Fox, Babak Taati
Levodopa is the gold standard therapy for Parkinson's disease (PD), but its prolonged usage leads to additional motor complications, namely levodopa-induced dyskinesia (LID). To assess LID and adjust drug regimens for optimal relief, patients attend regular clinic visits. However, the intermittent nature of these visits can fail to capture important changes in a person's condition. With the recent emergence of deep learning achieving impressive results in a wide array of fields including computer vision, there is an opportunity for video analysis to be used for automated assessment of LID...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29059830/weakly-supervised-learning-for-parkinson-s-disease-tremor-detection
#7
Ada Zhang, Alexander Cebulla, Stanislav Panev, Jessica Hodgins, Fernando De la Torre
Continuous, automated monitoring of Parkinsons Disease (PD) symptoms would provide clinicians with more information to understand their patients' disease progression and adjust treatment protocols, thereby improving PD care. Collecting precisely labeled data for Parkinson's symptoms, such as tremor, is difficult. Therefore, algorithms for monitoring should only require weakly-labeled training data. In this paper, we evaluate five standard weakly-supervised algorithms and propose a "stratified" version of three of the algorithms, which take advantage of knowing the approximate amount of tremor within each segment...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29047382/a-novel-and-fully-automated-mammographic-texture-analysis-for-risk-prediction-results-from-two-case-control-studies
#8
Chao Wang, Adam R Brentnall, Jack Cuzick, Elaine F Harkness, D Gareth Evans, Susan Astley
BACKGROUND: The percentage of mammographic dense tissue (PD) is an important risk factor for breast cancer, and there is some evidence that texture features may further improve predictive ability. However, relatively little work has assessed or validated textural feature algorithms using raw full field digital mammograms (FFDM). METHOD: A case-control study nested within a screening cohort (age 46-73 years) from Manchester UK was used to develop a texture feature risk score (264 cases diagnosed at the same time as mammogram of the contralateral breast, 787 controls) using the least absolute shrinkage and selection operator (LASSO) method for 112 features, and validated in a second case-control study from the same cohort but with cases diagnosed after the index mammogram (317 cases, 931 controls)...
October 18, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29044336/the-impact-of-body-mass-index-bmi-variation-on-mortality-of-incident-elderly-patients-on-peritoneal-dialysis-a-joint-model-analysis
#9
Marcia Regina Gianotti Franco, Fernando Antonio Basile Colugnati, Abdul Rashid Qureshi, José Carolino Divino-Filho, Natália Maria Da Silva Fernandes
INTRODUCTION: Data on impact of high body mass index (BMI) on mortality of patients on peritoneal dialysis (PD), especially among elderly, are inconsistent. Objective: To evaluate impact of BMI on cohort of incident elderly PD patients over time. METHODS: Prospective multicenter cohort study (December / 2004-October/2007) with 674 patients. Socio-demographic and clinical data evaluated with patients followed until death, transfer to hemodialysis (HD), recovery of renal function, loss of follow-up or transplant...
July 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29043246/follow-up-of-mothers-with-suspected-postpartum-depression-from-pediatrics-clinics
#10
Nerissa S Bauer, Susan Ofner, Amy Pottenger, Aaron E Carroll, Stephen M Downs
PURPOSE: Pediatric providers are increasingly screening for postpartum depression (PD), yet, it is unknown how often mothers comply with recommendations to seek treatment. The objectives were to describe the rate at which mothers with suspected PD seek treatment and explore factors that predict help-seeking behavior. DESIGN AND METHODS: Mothers were recruited from four pediatric clinics after identification using the Child Health Improvement through Computer Automation (CHICA) system...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29028832/correction-use-of-the-22c3-anti-pd-l1-antibody-to-determine-pd-l1-expression-in-multiple-automated-immunohistochemistry-platforms
#11
Marius Ilie, Shirin Khambata-Ford, Christiane Copie-Bergman, Lingkang Huang, Jonathan Juco, Veronique Hofman, Paul Hofman
[This corrects the article DOI: 10.1371/journal.pone.0183023.].
2017: PloS One
https://www.readbyqxmd.com/read/29024613/remote-monitoring-of-automated-peritoneal-dialysis-patients-assessing-clinical-and-economic-value
#12
Dilip Makhija, Mark Dominik Alscher, Stefan Becker, Silvia D'Alonzo, Raj Mehrotra, Leslie Wong, Kim McLeod, Judy Danek, Mary Gellens, Todd Kudelka, James A Sloand, Suzanne Laplante
BACKGROUND: For chronic kidney disease patients who progress to end-stage renal disease, survival is dependent on renal replacement therapy in the form of kidney transplantation or chronic dialysis. Peritoneal dialysis (PD), which can be performed at home, is both more convenient and less costly than hemodialysis that requires three 4-h visits per week to the dialysis facility and complicated equipment. Remote therapy management (RTM), technologies that collect medical information and transmit it to healthcare providers for patient management, has the potential to improve the outcomes of patients receiving automated peritoneal dialysis (APD) at home...
October 12, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28978362/reliability-and-utility-of-manual-and-automated-estimates-of-total-intracranial-volume
#13
Samuel J Crowley, Jared J Tanner, Daniel Ramon, Nadine A Schwab, Loren P Hizel, Catherine C Price
OBJECTIVES: Total intracranial volume (TICV) is an important control variable in brain-behavior research, yet its calculation has challenges. Manual TICV (Manual) is labor intensive, and automatic methods vary in reliability. To identify an accurate automatic approach we assessed the reliability of two FreeSurfer TICV metrics (eTIV and Brainmask) relative to manual TICV. We then assessed how these metrics alter associations between left entorhinal cortex (ERC) volume and story retention...
October 5, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28971009/refining-diagnosis-of-parkinson-s-disease-with-deep-learning-based-interpretation-of-dopamine-transporter-imaging
#14
Hongyoon Choi, Seunggyun Ha, Hyung Jun Im, Sun Ha Paek, Dong Soo Lee
Dopaminergic degeneration is a pathologic hallmark of Parkinson's disease (PD), which can be assessed by dopamine transporter imaging such as FP-CIT SPECT. Until now, imaging has been routinely interpreted by human though it can show interobserver variability and result in inconsistent diagnosis. In this study, we developed a deep learning-based FP-CIT SPECT interpretation system to refine the imaging diagnosis of Parkinson's disease. This system trained by SPECT images of PD patients and normal controls shows high classification accuracy comparable with the experts' evaluation referring quantification results...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28970363/comparison-of-change-in-peritoneal-function-in-patients-on-continuous-ambulatory-pd-vs-automated-pd
#15
Nasreen Samad, Stanley Fan
BACKGROUND: Patients on automated peritoneal dialysis (APD) may have greater exposure to glucose in the PD fluid than those on continuous ambulatory PD (CAPD). If this causes long-term damage to the peritoneal membrane, it will have implications for a patient's choice of modality. METHODS: Membrane function of long-term APD or CAPD patients was followed prospectively. The data were collected from electronic patient records in our unit from 2000 to 2014. The rate of change in membrane transport status (D/Pcr) and ultrafiltration (UF4) for each patient was calculated using the least square regression line equation...
September 28, 2017: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/28947525/successful-treatment-of-chronic-hepatitis-c-virus-infection-in-a-patient-receiving-daily-peritoneal-dialysis
#16
Jennifer E Stark, Jennifer Cole
PURPOSE: Successful use of a 4-drug oral fixed-dose combination therapy to treat chronic hepatitis C in a patient receiving peritoneal dialysis (PD) is reported. SUMMARY: New highly effective treatments for chronic hepatitis C virus (HCV) infection are now available, but safety and efficacy data on the use of anti-HCV therapies in patients with renal failure, particularly those requiring PD, remain limited. A 73-year-old black man with chronic HCV genotype 1a infection and stage 5 chronic renal disease requiring daily automated PD was referred for HCV treatment prior to renal transplantation...
October 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28940446/the-pd-1-and-pd-l1-pathway-in-recurrent-respiratory-papillomatosis
#17
Julie Ahn, Justin A Bishop, Richard B S Roden, Clint T Allen, Simon R A Best
OBJECTIVES/HYPOTHESIS: Generation of an immunosuppressive microenvironment may enable a persistent human papillomavirus infection in the setting of an otherwise normal immune system. We hypothesized that expression of the T-lymphocyte co-inhibitory receptor programmed death 1 (PD-1) and its ligand PD-L1 would be increased in the recurrent respiratory papillomatosis (RRP) microenvironment compared to normal controls. STUDY DESIGN: Case-control study. METHODS: Formalin-fixed paraffin-embedded respiratory papilloma and normal controls were obtained under institutional review board approval, stained for CD4, CD8, FoxP3, and PD-1, and scored by automated cell count...
September 22, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28884232/-18-f-av-1451-binding-to-neuromelanin-in-the-substantia-nigra-in-pd-and-psp
#18
Sarah Coakeley, Sang Soo Cho, Yuko Koshimori, Pablo Rusjan, Christine Ghadery, Jinhee Kim, Anthony E Lang, Sylvain Houle, Antonio P Strafella
This study investigated binding of [(18)F]AV-1451 to neuromelanin in the substantia nigra of patients with Parkinson's disease (PD) and progressive supranuclear palsy (PSP). [(18)F]AV-1451 is a positron emission tomography radiotracer designed to bind pathological tau. A post-mortem study using [(18)F]AV-1451 discovered off-target binding properties to neuromelanin in the substantia nigra. A subsequent clinical study reported a 30% decrease in [(18)F]AV-1451 binding in the midbrain of PD patients. A total of 12 patients and 10 healthy age-matched controls were recruited...
September 7, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28878734/speech-and-voice-response-to-a-levodopa-challenge-in-late-stage-parkinson-s-disease
#19
Margherita Fabbri, Isabel Guimarães, Rita Cardoso, Miguel Coelho, Leonor Correia Guedes, Mario M Rosa, Catarina Godinho, Daisy Abreu, Nilza Gonçalves, Angelo Antonini, Joaquim J Ferreira
BACKGROUND: Parkinson's disease (PD) patients are affected by hypokinetic dysarthria, characterized by hypophonia and dysprosody, which worsens with disease progression. Levodopa's (l-dopa) effect on quality of speech is inconclusive; no data are currently available for late-stage PD (LSPD). OBJECTIVE: To assess the modifications of speech and voice in LSPD following an acute l-dopa challenge. METHOD: LSPD patients [Schwab and England score <50/Hoehn and Yahr stage >3 (MED ON)] performed several vocal tasks before and after an acute l-dopa challenge...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28877231/functional-characterization-of-t-cells-from-palatine-tonsils-in-patients-with-chronic-tonsillitis
#20
Katharina Geißler, Robby Markwart, Robert Pascal Requardt, Cynthia Weigel, Katja Schubert, André Scherag, Ignacio Rubio, Orlando Guntinas-Lichius
The palatine tonsils, localized in the oropharynx, are easily accessible secondary lymphoid tissue in humans. Inflammation of the palatine tonsils, local and chronic in case of chronic tonsillitis (CT) or acute in the presence of a peritonsillar abscess (PTA), ranks among the most common diseases in otolaryngology. However, the functionality of tonsillar immune cells, notably T-cells, in the context of these immune pathologies is poorly understood. We have examined the functional status of human tonsillar T-cells in CT and compared it to the acute inflammatory setting of a PTA...
2017: PloS One
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